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https://www.readbyqxmd.com/read/28333377/circadian-rhythms-in-adipose-tissue-physiology
#1
Jana-Thabea Kiehn, Anthony H Tsang, Isabel Heyde, Brinja Leinweber, Isa Kolbe, Alexei Leliavski, Anthony H Tsang
The different types of adipose tissues fulfill a wide range of biological functions-from energy storage to hormone secretion and thermogenesis-many of which show pronounced variations over the course of the day. Such 24-h rhythms in physiology and behavior are coordinated by endogenous circadian clocks found in all tissues and cells, including adipocytes. At the molecular level, these clocks are based on interlocked transcriptional-translational feedback loops comprised of a set of clock genes/proteins. Tissue-specific clock-controlled transcriptional programs translate time-of-day information into physiologically relevant signals...
March 16, 2017: Comprehensive Physiology
https://www.readbyqxmd.com/read/28316058/retrospective-analysis-of-clinical-and-virological-parameters-of-influenza-cases-at-four-university-hospitals-in-germany-2015
#2
Robert Heyd, Anna Maria Eis-Hübinger, Annemarie Berger, Sibylle Bierbaum, Sandra Pietzonka, Jürgen J Wenzel, Daniela Huzly, Oliver T Keppler, Marcus Panning
We conducted a retrospective observational study at four German university hospitals of patients with laboratory-confirmed influenza in 2014/2015. Overall, a fatality rate of 8% was observed. Significantly more A(H1N1)pdm09 patients were admitted to ICU compared to those with A(H3N2). However, fatal outcome was not significantly increased among A(H1N1)pdm09 cases. Nosocomial infections were seen in 17% of cases. Systematic collection of data from hospitals will complement national influenza surveillance.
March 18, 2017: Infection
https://www.readbyqxmd.com/read/28315984/thermomechanical-method-for-cement-extraction-in-revision-arthroplasty
#3
M Ghanem, A Koenig, F Dehn, C-E Heyde, C Josten
BACKGROUND: In joint revision surgery, bone cement extraction remains a major challenge which even today has not seen a satisfactory solution yet. We studied in an experimental setting the impact of heat sources on the mechanical properties and microstructure of bone cement and determined the glass transition temperature (T G) of bone cement. As a result, it would be possible to establish a thermomechanical method which makes use of the structural and material-specific property changes inherent in bone cement at elevated temperatures...
March 18, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28278451/reference-free-adjustment-of-respiratory-inductance-plethysmography-for-measurements-during-physical-exercise
#4
Heike Leutheuser, Christian Heyde, Kai Roecker, Albert Gollhofer, Bjoern Eskofier
OBJECTIVE: Respiratory inductance plethysmography (RIP) provides an unobtrusive method for measuring breathing characteristics. Accurately adjusted RIP provides reliable measurements of ventilation during rest and exercise if data are acquired via two elastic measuring bands surrounding the rib cage (RC) and abdomen (AB). Disadvantageously, the most accurate reported adjusted model for RIP in literature-least squares regression-requires simultaneous RIP and flowmeter (FM) data acquisition...
March 3, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28276127/heyde-s-syndrome-revisited-anaemia-and-aortic-stenosis
#5
Catherina Tjahjadi, Yong Wee, Karen Hay, Peter Tesar, Andrew Clarke, Darren L Walters, Nicholas Bett
BACKGROUND: The association of anaemia with aortic stenosis (AS) has been recognised for over 50 years but although there have been a number of sporadic reports there are little data on the prevalence of this syndrome. AIMS: We sought to compare the prevalence of anaemia in adults with AS with that of controls who had undergone coronary artery bypass grafting (CABG). METHODS: We conducted a retrospective cohort study comparing pre-procedural levels of haemoglobin in 1537 adults who underwent aortic valve replacement (AVR) for AS with 8025 contemporaneous patients who had CABG...
March 9, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28271148/emergency-surgery-for-obstructing-colonic-cancer-a-comparison-between-right-sided-and-left-sided-lesions
#6
J-L Faucheron, B Paquette, B Trilling, B Heyd, S Koch, G Mantion
PURPOSE: Few studies compare management and outcomes of obstructive colonic cancer, depending on the tumor site. We aim to evaluate the differences in patient characteristics, tumor characteristics, and outcomes of emergency surgery for obstructive right-sided versus left-sided colonic cancers. METHODS: Between 2000 and 2009, 71 consecutive patients had an emergency colectomy following strict and clear definition of obstruction in a single institution. We retrospectively analyzed pre, per, and postoperative data that were prospectively collected...
March 7, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28219552/unusual-gastrointestinal-bleeding-after-sutureless-aortic-valve-replacement-a-word-of-caution
#7
Jules Iquille, Joseph Nader, Eric Colpart, Thierry Caus
We report the clinical case of a male patient who presented, after an aortic valve replacement with a rapid deployment bioprosthesis, a Heyde-like syndrome, secondary to a moderate aortic paravalvular leakage. All the digestive and hematologic investigations confirmed the diagnosis. A redo surgery to fill the paravalvular gap was accomplished and the postoperative course was uneventful, with a normalization of the biological parameters. To our knowledge, this is the first described case of such a complication with the new generation of sutureless bioprosthesis...
March 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28209163/cardiovascular-magnetic-resonance-myocardial-feature-tracking-using-a-non-rigid-elastic-image-registration-algorithm-assessment-of-variability-in-a-real-life-clinical-setting
#8
Pedro Morais, Alberto Marchi, Julie A Bogaert, Tom Dresselaers, Brecht Heyde, Jan D'hooge, Jan Bogaert
BACKGROUND: Cardiovascular magnetic resonance myocardial feature tracking (CMR-FT) is a promising technique for quantification of myocardial strain from steady-state free precession (SSFP) cine images. We sought to determine the variability of CMR-FT using a non-rigid elastic registration algorithm recently available in a commercial software package (Segment, Medviso) in a real-life clinical setting. METHODS: Firstly, we studied the variability in a healthy volunteer who underwent 10 CMR studies over five consecutive days...
February 17, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28207014/severe-henoch-sch%C3%A3-nlein-purpura-complicating-infliximab-therapy-for-ulcerative-colitis
#9
Claire Laresche, Fanny Locatelli, Caroline Biver-Dalle, Maria Nachury, Bruno Heyd, Stéphane Koch, François Aubin
No abstract text is available yet for this article.
January 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28188341/evaluation-of-transcriptomic-signature-as-a-valuable-tool-to-study-drug-induced-cholestasis-in-primary-human-hepatocytes
#10
Céline Parmentier, Philippe Couttet, Armin Wolf, Thomas Zaccharias, Bruno Heyd, Philippe Bachellier, Marianne Uteng, Lysiane Richert
Primary human hepatocyte (PHH) sandwich cultures from five different donors were daily exposed to cyclosporine A (CsA), ibuprofen (IBU), chlorpromazine (CPZ), amiodarone (AMI) and paracetamol (APAP) at their respective Cmax (total) for short-term (1-3 days) and long-term treatment (14 days). Whole genome mRNA profiles (34,693 genes in total) were conducted using an Illumina microarray platform. The impact of compound treatments on gene signatures involved in liver differentiation, cholestasis and in bile acid homeostasis was evaluated...
February 10, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28120111/arbuscular-mycorrhizal-fungus-responses-to-disturbance-are-context-dependent
#11
Mieke van der Heyde, Brian Ohsowski, Lynette K Abbott, Miranda Hart
Anthropogenic disturbance is one of the most important forces shaping soil ecosystems. While organisms that live in the soil, such as arbuscular mycorrhizal (AM) fungi, are sensitive to disturbance, their response is not always predictable. Given the range of disturbance types and differences among AM fungi in their growth strategies, the unpredictability of the responses of AM fungi to disturbance is not surprising. We investigated the role of disturbance type (i.e., soil disruption, agriculture, host perturbation, and chemical disturbance) and fungus identity on disturbance response in the AM symbiosis...
January 24, 2017: Mycorrhiza
https://www.readbyqxmd.com/read/28115991/the-impact-of-economic-rationalization-prioritization-and-rationing-on-job-satisfaction-motivation-and-team-cohesion-in-hospitals-a-survey-among-retired-physician-executives-in-germany
#12
Joerg Schnoor, Elmar Braehler, Mohamed Ghanem, Christoph E Heyde
BACKGROUND: The growing economization of the health care system and implication of market principles in the medical field have risen new and serious questions on the meaning of the medical profession, the doctor-patient relationship and the orientation of medicine itself. The impact of the dynamic clinical structures on the doctor-doctor and the doctor-patient interaction appear even unpredictable. Therefore, the impact of market-based methods, i.e. rationalization, prioritization and rationing, on job satisfaction, motivation and team cohesion should be quantified...
2017: Patient Safety in Surgery
https://www.readbyqxmd.com/read/28113779/a-model-of-a-synthetic-biological-communication-interface-between-mammalian-cells-and-mechatronic-systems
#13
Keith Cameron Heyde, Warren Christopher Ruder
The creation of communication interfaces between abiotic and biotic systems represents a significant research challenge. In this work, we design and model a system linking the biochemical signaling pathways of mammalian cells to the actions of a mobile robotic prosthesis. We envision this system as a robotic platform carrying an optically monitored bioreactor that harbors mammalian cells. The cellular, optical signal is captured by an onboard fluorescent microscope and converted into an electronic signal. We first present a design for the overall cellrobot system, with a specific focus on the design of the synthetic gene networks needed for the system...
October 25, 2016: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28096086/platelets-activate-a-pathogenic-response-to-blood-stage-plasmodium-infection-but-not-a-protective-immune-response
#14
Irene Gramaglia, Joyce Velez, Valery Combes, Georges E R Grau, Melanie Wree, Henri C van der Heyde
Clinical studies indicate that thrombocytopenia correlates with the development of severe falciparum malaria, suggesting that platelets either contribute to control of parasite replication possibly as innate parasite killer cells or function in eliciting pathogenesis. Removal of platelets by anti-CD41 mAb treatment, platelet inhibition by aspirin, and adoptive transfer of WT platelets to CD40-KO mice, which do not control parasite replication, resulted in similar parasitemia compared with control mice. Human platelets at a physiological ratio of 1 platelet to 9 RBCs did not inhibit the in vitro development or replication of blood-stage P...
January 17, 2017: Blood
https://www.readbyqxmd.com/read/28093624/osteoporotic-vertebral-body-fractures-of-the-thoracolumbar-spine-indications-and-techniques-of-a-360%C3%A2-stabilization
#15
Ulrich Spiegl, J-S Jarvers, C-E Heyde, C Josten
Unstable vertebral body fragility fractures of the thoracolumbar spine can occur with or without relevant trauma. Initially, a standardized diagnostic algorithm including magnetic resonance tomography is recommended to detect accompanied further vertebral body fractures, to interpret the individual fracture stability, and to screen for relevant traumatic intervertebral disc lesions. Aim of the therapy is to assure fast mobilization and to maintain spinal alignment. Unstable fracture morphology is defined by vertebral body fractures including a relevant defect of the posterior vertebral cortex as well as type B or C fractures...
February 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28092500/a-model-of-a-synthetic-biological-communication-interface-between-mammalian-cells-and-mechatronic-systems
#16
Keith C Heyde, Warren C Ruder
The creation of communication interfaces between abiotic and biotic systems represents a significant research challenge. In this work, we design and model a system linking the biochemical signaling pathways of mammalian cells to the actions of a mobile robotic prosthesis. We envision this system as a robotic platform carrying an optically monitored bioreactor that harbors mammalian cells. The cellular, optical signal is captured by an onboard fluorescent microscope and converted into an electronic signal. We first present a design for the overall cell-robot system, with a specific focus on the design of the synthetic gene networks needed for the system...
December 2016: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28088607/transcatheter-aortic-valve-implantation-leads-to-a-restoration-of-von-willebrand-factor-vwf-abnormalities-in-patients-with-severe-aortic-stenosis-incidence-and-relevance-of-clinical-and-subclinical-vwf-dysfunction-in-patients-undergoing-transfemoral-tavi
#17
Alexander Sedaghat, Hannah Kulka, Jan-Malte Sinning, Nora Falkenberg, Julia Driesen, Barbara Preisler, Christoph Hammerstingl, Georg Nickenig, Bernd Pötzsch, Johannes Oldenburg, Hans-Jörg Hertfelder, Nikos Werner
BACKGROUND: In this study, we sought to analyze the incidence and relevance of von Willebrand factor (VWF) abnormalities in patients undergoing transcatheter aortic valve implantation (TAVI), especially on perioperative bleeding. Furthermore, we hypothesized that, similar to aortic valve surgery, TAVI results in a restoration of VWF abnormalities. METHODS AND RESULTS: We performed a prospective analysis of periinterventional VWF parameters in 74 patients (80±7years, female in 37...
January 7, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28031331/activation-dependent-traf3-exon-8-alternative-splicing-is-controlled-by-celf2-and-hnrnp-c-binding-to-an-upstream-intronic-element
#18
Astrid-Solveig Schultz, Marco Preußner, Mario Bunse, Rotem Karni, Florian Heyd
Cell-type specific and inducible alternative splicing has a fundamental impact on regulating gene expression and cellular function in a variety of settings including activation and differentiation. We have recently shown that activation-induced skipping of TRAF3 exon 8 activates non-canonical NFkB signaling upon T cell stimulation, but the regulatory basis for this splicing event remains unknown. Here we identify cis- and trans-regulatory elements rendering this splicing switch activation-dependent and cell-type specific...
December 28, 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28009024/doping-anatase-tio2-with-group-v-b-and-vi-b-transition-metal-atoms-a-hybrid-functional-first-principles-study
#19
Masahiko Matsubara, Rolando Saniz, Bart Partoens, Dirk Lamoen
We investigate the role of transition metal atoms of group V-b (V, Nb, and Ta) and VI-b (Cr, Mo, and W) as n- or p-type dopants in anatase TiO2 using thermodynamic principles and density functional theory with the Heyd-Scuseria-Ernzerhof HSE06 hybrid functional. The HSE06 functional provides a realistic value for the band gap, which ensures a correct classification of dopants as shallow or deep donors or acceptors. Defect formation energies and thermodynamic transition levels are calculated taking into account the constraints imposed by the stability of TiO2 and the solubility limit of the impurities...
January 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27992332/left-ventricular-myocardial-segmentation-in-3-d-ultrasound-recordings-effect-of-different-endocardial-and-epicardial-coupling-strategies
#20
Joao Pedrosa, Daniel Barbosa, Brecht Heyde, Frederic Schnell, Assami Rosner, Piet Claus, Jan D'hooge
Cardiac volume/function assessment remains a critical step in daily cardiology, and 3-D ultrasound plays an increasingly important role. Though development of automatic endocardial segmentation methods has received much attention, the same cannot be said about epicardial segmentation, in spite of the importance of full myocardial segmentation. In this paper, different ways of coupling the endocardial and epicardial segmentations are contrasted and compared with uncoupled segmentation. For this purpose, the B-spline explicit active surfaces framework was used; 27 3-D echocardiographic images were used to validate the different coupling strategies, which were compared with manual contouring of the endocardial and epicardial borders performed by an expert...
March 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
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