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Tobias S Kaiser, Birgit Poehn, David Szkiba, Marco Preussner, Fritz J Sedlazeck, Alexander Zrim, Tobias Neumann, Lam-Tung Nguyen, Andrea J Betancourt, Thomas Hummel, Heiko Vogel, Silke Dorner, Florian Heyd, Arndt von Haeseler, Kristin Tessmar-Raible
Organisms use endogenous clocks to anticipate regular environmental cycles, such as days and tides. Natural variants resulting in differently timed behaviour or physiology, known as chronotypes in humans, have not been well characterized at the molecular level. We sequenced the genome of Clunio marinus, a marine midge whose reproduction is timed by circadian and circalunar clocks. Midges from different locations show strain-specific genetic timing adaptations. We examined genetic variation in five C. marinus strains from different locations and mapped quantitative trait loci for circalunar and circadian chronotypes...
December 1, 2016: Nature
Kristen M Burson, Christin Büchner, Markus Heyde, Hans-Joachim Freund
Domain boundaries are hypothesized to play a role in the crystalline to amorphous transition. Here we examine domain boundary structures in comparison to crystalline and amorphous structures in bilayer silica grown on Ru(0 0 0 1). Atomically resolved scanning probe microscopy data of boundaries in crystalline bilayer films are analyzed to determine structural motifs. A rich variety of boundary structures including rotational, closed-loop, antiphase, and complex boundaries are identified. Repeating units with ring sizes of 558 and 57 form the two most common domain boundary types...
November 15, 2016: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Wen-Zhi Xiao, Gang Xiao, Ling-Ling Wang
We report the structural, electronic, magnetic, and elastic properties of a two-dimensional (2D) honeycomb stannic oxide (SnO2) monolayer based on comprehensive first-principles calculations. The free-standing and well-ordered 2D centered honeycomb SnO2 (T-SnO2) monolayer with D3d point-group symmetry has good dynamical stability, as well as thermal stability at 500 K. The T-SnO2 monolayer is a nonmagnetic wide-bandgap semiconductor with an indirect bandgap of 2.55/4.13 eV obtained by the generalized gradient approximation with the Perdew-Burke-Ernzerhof/Heyd-Scuseria-Ernzerhof hybrid functional, but it acquires a net magnetic moment upon creation of a Sn vacancy defect...
November 7, 2016: Journal of Chemical Physics
Brecht Heyde, Nick Bottenus, Jan D'hooge, Gregg E Trahey
The transverse oscillation (TO) technique can improve the estimation of tissue motion perpendicular to the ultrasound beam direction. TOs can be introduced using plane wave (PW) insonification and bi-lobed Gaussian apodisation (BA) on receive (abbreviated as PWTO). Furthermore, the TO frequency can be doubled after a heterodyning demodulation process is performed (abbreviated as PWTO*). This study is concerned with identifying the limitations of the PWTO technique in the specific context of myocardial deformation imaging with phased arrays and investigating the conditions in which it remains advantageous over traditional focused (FOC) beamforming...
October 28, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Christelle d'Engremont, Dewi Vernerey, Anne-Laure Pointet, Gaël Simone, Francine Fein, Bruno Heyd, Stéphane Koch, Lucine Vuitton, Stefano Kim, Marine Jary, Najib Lamfichek, Celia Turco, Zaher Lakkis, Anne Berger, Franck Bonnetain, Julien Taieb, Philippe Bachellier, Christophe Borg
BACKGROUND: Pancreatic adenocarcinoma (PDAC) incidence is increasing worldwide. Several studies have shown that lymphopenia was correlated with a poor prognosis but the potential interest to measure lymphopenia in the pre and post-operative setting as well as its added value among conventional prognostic factors was never investigated. METHODS: Data from two independent cohorts in whom patients underwent resection for pancreatic carcinoma were retrospectively recorded...
October 26, 2016: BMC Cancer
Gisele Farias, Rubia D Thieme, Laila M Teixeira, Maria Emilia V D Heyde, Solange C Bettini, Rosana B Radominski
BACKGROUND: Bariatric surgery is one of the main treatments for severity obesity, but weight regain after surgery is an important issue. OBJECTIVES: To compare the clinical and nutritional profiles of good and poor weight loss responders in the late postoperative period after bariatric surgery. METHODS: A cross-sectional study with patients undergoing Roux-en-Y gastric bypass in a University Hospital. Patients were divided into good weight loss responders (GWLR) and poor weight loss responders (PWLR) defined as ≥ 50% or < 50% excess weight loss (EWL), respectively, at least 2 years post-surgery...
September 20, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Alejandra Ortega, Jean Provost, Ling Tong, Pedro Santos, Brecht Heyde, Mathieu Pernot, Jan D'hooge
It was previously demonstrated in 2-D echocardiography that a proper multiline transmit (MLT) implementation can be used to increase frame rate while preserving image quality. Initial findings for extending MLT to 3-D showed that it might address the low spatiotemporal resolution of current volumetric ultrasound systems. However, to date, it remains unclear how much transmit/receive parallelization would be possible using a 3-D MLT system. Therefore, the aim of this paper was to contrast different MLT setups for 3-D imaging by computer simulation in order to determine an optimal tradeoff between the amount of parallelization of an MLT system and the corresponding signal-to-noise ratio of the resulting images...
December 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
K C Heyde, P W Gallagher, W C Ruder
Biomimetic robots have been used to explore and explain natural phenomena ranging from the coordination of ants to the locomotion of lizards. Here, we developed a series of decision architectures inspired by the information exchange between a host organism and its microbiome. We first modeled the biochemical exchanges of a population of synthetically engineered E. coli. We then built a physical, differential drive robot that contained an integrated, onboard computer vision system. A relay was established between the simulated population of cells and the robot's microcontroller...
2016: Bioinspiration & Biomimetics
C Josten, C-E Heyde, U J Spiegl
Treating vertebral body fractures is challenging when there is relevant pre-existing spinal degeneration. Both vertebral body fractures and spinal degeneration are related to the physiological aging process. The increases in both are linked to increases in life expectancy. Several factors promote spinal degeneration and increase fracture risk, such as disc degeneration, spinal imbalance and osteoporosis. The main diagnostic and therapeutic challenge is to identify the sources of pain and to start appropriate therapy...
October 2016: Zeitschrift Für Orthopädie und Unfallchirurgie
Joanne Cleland, James M Scobbie, Cornelia Heyde, Zoe Roxburgh, Alan A Wrench
Acoustic and articulatory studies demonstrate covert contrast in perceptually neutralised phonemic contrasts in both typical children and children with speech disorders. These covert contrasts are thought to be relatively common and symptomatic of phonetic speech disorders. However, clinicians in the speech therapy clinic have had no easy way of identifying this covertness. This study uses ultrasound tongue imaging to compare tongue contours for /t/and /k/in seven children with persistent velar fronting. We present a method of overlaying tongue contours to identify covert contrast at the articulatory level...
September 9, 2016: Clinical Linguistics & Phonetics
D J Huang, L Q Kong, Z Wu
No abstract text is available yet for this article.
September 1, 2016: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
S Bouchez, B Heyde, D Barbosa, M Vandenheuvel, H Houle, Y Wang, J D'hooge, P F Wouters
Three-dimensional (3D) strain analysis based on real-time 3-D echocardiography (RT3DE) has emerged as a novel technique to quantify regional myocardial function. The goal of this study was to evaluate accuracy of a novel model-based 3D tracking tool (eSie Volume Mechanics, Siemens Ultrasound, Mountain View, CA, USA) using sonomicrometry as an independent measure of cardiac deformation. Thirteen sheep were instrumented with microcrystals sutured to the epi- and endocardium of the inferolateral left ventricular wall to trace myocardial deformation along its three directional axes of motion...
August 17, 2016: International Journal of Cardiovascular Imaging
Yu Meng, Xing-Wu Liu, Chun-Fang Huo, Wen-Ping Guo, Dong-Bo Cao, Qing Peng, Albert Dearden, Xavier Gonze, Yong Yang, Jianguo Wang, Haijun Jiao, Yongwang Li, Xiao-Dong Wen
Three density functional approximations (DFAs), PBE, PBE+U, and Heyd-Scuseria-Ernzerhof screened hybrid functional (HSE), were employed to investigate the geometric, electronic, magnetic, and thermodynamic properties of four iron oxides, namely, α-FeOOH, α-Fe2O3, Fe3O4, and FeO. Comparing our calculated results with available experimental data, we found that HSE (a = 0.15) (containing 15% "screened" Hartree-Fock exchange) can provide reliable values of lattice constants, Fe magnetic moments, band gaps, and formation energies of all four iron oxides, while standard HSE (a = 0...
October 11, 2016: Journal of Chemical Theory and Computation
Peter Melcher, Dirk Zajonz, Andreas Roth, Christoph-E Heyde, Mohamed Ghanem
BACKGROUND: The OSCE (objective structured clinical examination) is composed of oral and practical examination in order to examine students' abilities to imply clinical examination techniques and to interact with patients. The examiners for this procedure can be either lecturers or peers. The aim of this work is to evaluate the peer-assisted teaching student tutors as examiners in an orthopedic surgery OSCE station. METHODS: We analyzed the OSCE data from 2013 to 2015...
2016: GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW
Ilka Wilhelmi, Regina Kanski, Alexander Neumann, Olga Herdt, Florian Hoff, Ralf Jacob, Marco Preußner, Florian Heyd
The transport of secretory proteins from the endoplasmic reticulum (ER) to the Golgi depends on COPII-coated vesicles. While the basic principles of the COPII machinery have been identified, it remains largely unknown how COPII transport is regulated to accommodate tissue- or activation-specific differences in cargo load and identity. Here we show that activation-induced alternative splicing of Sec16 controls adaptation of COPII transport to increased secretory cargo upon T-cell activation. Using splice-site blocking morpholinos and CRISPR/Cas9-mediated genome engineering, we show that the number of ER exit sites, COPII dynamics and transport efficiency depend on Sec16 alternative splicing...
2016: Nature Communications
Bárbara Dal Molin Netto, Carrie P Earthman, Gisele Farias, Deborah Cristina Landi Masquio, Ana Paula Grotti Clemente, Priscilla Peixoto, Solange Cravo Bettini, Maria Emilia von Der Heyde, Ana R Dâmaso
OBJECTIVE: Significant changes in the preference for different dietary components have been observed after Roux-en-Y gastric bypass (RYGB). The aim of this study was to evaluate the early post-RYGB changes in quality of eating patterns and their relationship to weight loss and metabolic parameters. METHODS: The sample was composed of 41 extremely obese individuals undergoing RYGB. Dietary data were collected using a validated food frequency questionnaire in Brazil...
January 2017: Nutrition
V Kepenekian, D Elias, G Passot, E Mery, D Goere, D Delroeux, F Quenet, G Ferron, D Pezet, J M Guilloit, P Meeus, M Pocard, J M Bereder, K Abboud, C Arvieux, C Brigand, F Marchal, J M Classe, G Lorimier, C De Chaisemartin, F Guyon, P Mariani, P Ortega-Deballon, S Isaac, C Maurice, F N Gilly, O Glehen
PURPOSE: Diffuse malignant peritoneal mesothelioma (DMPM) is a severe disease with mainly locoregional evolution. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is the reported treatment with the longest survival. The aim of this study was to evaluate the impact of perioperative systemic chemotherapy strategies on survival and postoperative outcomes in patients with DMPM treated with curative intent with CRS-HIPEC, using a multi-institutional database: the French RENAPE network...
September 2016: European Journal of Cancer
Joseph L Blackshear, Chad W McRee, Robert E Safford, Peter M Pollak, Mark E Stark, Colleen S Thomas, Candido E Rivera, Ewa M Wysokinska, Dong Chen
IMPORTANCE: Limited data suggest that von Willebrand factor (VWF) abnormalities may accompany the high-shear state associated with prosthetic valve dysfunction. If true, laboratory testing could add value in quantifying prosthesis dysfunction and could suggest a pathophysiological explanation for acquired bleeding in some patients. OBJECTIVES: To determine whether dysfunctional valve prostheses are associated with VWF abnormalities compared with normally functioning valve prostheses, to identify the severity of the VWF abnormality relative to other conditions, and to describe associated bleeding and the occurrence of gastrointestinal angiodysplasia...
May 1, 2016: JAMA Cardiology
Christin Büchner, Zhu-Jun Wang, Kristen M Burson, Marc-Georg Willinger, Markus Heyde, Robert Schlögl, Hans-Joachim Freund
An atomically smooth silica bilayer is transferred from the growth substrate to a new support via mechanical exfoliation at millimeter scale. The atomic structure and morphology are maintained perfectly throughout the process. A simple heating treatment results in complete removal of the transfer medium. Low-energy electron diffraction, Auger electron spectroscopy, scanning tunneling microscopy, and environmental scanning electron microscopy show the success of the transfer steps. Excellent chemical and thermal stability result from the absence of dangling bonds in the film structure...
August 23, 2016: ACS Nano
Biao Liu, Li-Juan Wu, Yu-Qing Zhao, Lin-Zhi Wang, Meng-Qiu Caii
The structures and electronic properties of the phosphorene and graphene heterostructure are investigated by density functional calculations using the hybrid Heyd-Scuseria-Ernzerhof (HSE) functional. The results show that the intrinsic properties of phosphorene and graphene are preserved due to the weak van der Waals contact. But the electronic properties of the Schottky contacts in the phosphorene and graphene heterostructure can be tuned from p-type to n-type by the in-plane compressive strains from -2% to -4%...
July 20, 2016: Physical Chemistry Chemical Physics: PCCP
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