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Listeria infection in neonates

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https://www.readbyqxmd.com/read/27074026/il-12p40-il-10-producing-precd8%C3%AE-clec9a-dendritic-cells-are-induced-in-neonates-upon-listeria-monocytogenes-infection
#1
David Torres, Arnaud Köhler, Sandrine Delbauve, Irina Caminschi, Mireille H Lahoud, Ken Shortman, Véronique Flamand
Infection by Listeria monocytogenes (Lm) causes serious sepsis and meningitis leading to mortality in neonates. This work explored the ability of CD11c(high) lineage DCs to induce CD8+ T-cell immune protection against Lm in mice before 7 days of life, a period symbolized by the absence of murine IL-12p70-producing CD11c(high)CD8α+ dendritic cells (DCs). We characterized a dominant functional Batf3-dependent precursor of CD11c(high) DCs that is Clec9A+CD205+CD24+ but CD8α- at 3 days of life. After Lm-OVA infection, these pre-DCs that cross-present Ag display the unique ability to produce high levels of IL-12p40 (not IL-12p70 nor IL-23), which enhances OVA-specific CD8+ T cell response, and regulatory IL-10 that limits OVA-specific CD8+ T cell response...
April 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/26772166/reductions-in-neonatal-listeriosis-collateral-benefit-of-group-b-streptococcal-prophylaxis
#2
Brian Lee, Jason G Newland, Ravi Jhaveri
OBJECTIVES: We tested the hypothesis that declines in Listeria monocytogenes in infants are related to declines in rates of early-onset Group B Streptococcus (GBS) infections associated with widespread prophylaxis using agents with Listeria activity. METHODS: We performed a retrospective cohort analysis using a national administrative database Pediatric Health Information System (PHIS). We searched for ICD-9 codes for Listeriosis in infants <30 days old and for early-onset GBS infection of any kind in infants <5 days old during the study period...
March 2016: Journal of Infection
https://www.readbyqxmd.com/read/26343962/nonclinical-development-of-bcg-replacement-vaccine-candidates
#3
Kamalakannan Velmurugan, Leander Grode, Rosemary Chang, Megan Fitzpatrick, Dominick Laddy, David Hokey, Steven Derrick, Sheldon Morris, David McCown, Reginald Kidd, Martin Gengenbacher, Bernd Eisele, Stefan H E Kaufmann, John Fulkerson, Michael J Brennan
The failure of current Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccines, given to neonates to protect against adult tuberculosis and the risk of using these live vaccines in HIV-infected infants, has emphasized the need for generating new, more efficacious and safer replacement vaccines. With the availability of genetic techniques for constructing recombinant BCG (rBCG) strains containing well-defined gene deletions or insertions, new vaccine candidates are under evaluation at both the preclinical and clinical stages of development...
2013: Vaccines
https://www.readbyqxmd.com/read/26147648/age-related-gene-expression-differences-in-monocytes-from-human-neonates-young-adults-and-older-adults
#4
Michelle M Lissner, Brandon J Thomas, Kathleen Wee, Ann-Jay Tong, Tobias R Kollmann, Stephen T Smale
A variety of age-related differences in the innate and adaptive immune systems have been proposed to contribute to the increased susceptibility to infection of human neonates and older adults. The emergence of RNA sequencing (RNA-seq) provides an opportunity to obtain an unbiased, comprehensive, and quantitative view of gene expression differences in defined cell types from different age groups. An examination of ex vivo human monocyte responses to lipopolysaccharide stimulation or Listeria monocytogenes infection by RNA-seq revealed extensive similarities between neonates, young adults, and older adults, with an unexpectedly small number of genes exhibiting statistically significant age-dependent differences...
2015: PloS One
https://www.readbyqxmd.com/read/25955775/cheese-related-listeriosis-outbreak-portugal-march-2009-to-february-2012
#5
R Magalhaes, G Almeida, V Ferreira, I Santos, J Silva, M M Mendes, J Pita, G Mariano, I Mancio, M M Sousa, J Farber, F Pagotto, P Teixeira
In Portugal, listeriosis has been notifiable since April 2014, but there is no active surveillance programme for the disease. A retrospective study involving 25 national hospitals led to the detection of an outbreak that occurred between March 2009 and February 2012. The amount of time between the start of the outbreak and its detection was 16 months. Of the 30 cases of listeriosis reported, 27 were in the Lisbon and Vale do Tejo region. Two cases were maternal/neonatal infections and one resulted in fetal loss...
2015: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/25476765/metal-ion-homeostasis-in-listeria-monocytogenes-and-importance-in-host-pathogen-interactions
#6
REVIEW
Helen E Jesse, Ian S Roberts, Jennifer S Cavet
Listeria monocytogenes is responsible for one of the most life-threatening food-borne infections and the leading cause of food-poisoning associated deaths in the UK. Infection may be of the unborn/newly born infant where disease may manifest as listeric abortion, stillbirth or late-onset neonatal listeriosis, while in adults, infection usually affects the central nervous system causing meningitis. Crucial to the survival of L. monocytogenes, both inside and outside the host, is its ability to acquire metals which act as cofactors for a broad range of its cellular proteins...
2014: Advances in Microbial Physiology
https://www.readbyqxmd.com/read/25411758/committee-opinion-no-614-management-of-pregnant-women-with-presumptive-exposure-to-listeria-monocytogenes
#7
(no author information available yet)
Listeriosis is predominantly a foodborne illness, with sporadic and outbreak-related cases tied to consumption of food contaminated with listeria (Listeria monocytogenes). The incidence of listeriosis associated with pregnancy is approximately 13 times higher than in the general population. Maternal infection may present as a nonspecific, flu-like illness with fever, myalgia, backache, and headache, often preceded by diarrhea or other gastrointestinal symptoms. However, fetal and neonatal infections can be severe, leading to fetal loss, preterm labor, neonatal sepsis, meningitis, and death...
December 2014: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/25361468/genetic-and-phenotypic-characterization-of-listeria-monocytogenes-from-human-clinical-cases-that-occurred-in-portugal-between-2008-and-2012
#8
Rui Magalhães, Vânia Ferreira, Isabel Santos, Gonçalo Almeida, Paula Teixeira
Listeria monocytogenes infection (listeriosis) is an uncommon but severe foodborne illness that affects mainly individuals with recognized underlying conditions: the elderly, immunocompromised individuals, and pregnant women and their fetuses. The aim of this study was to obtain epidemiological data on cases of listeriosis occurring in Portugal from 2008 through 2012, collected in hospitals on a voluntary basis. L. monocytogenes isolates were characterized by genoserotyping by multiplex polymerase chain reaction, DNA macrorestriction pulsed-field gel electrophoresis (PFGE), and determination of minimal inhibitory concentration (MIC, μg/mL) for 12 antibiotics...
November 2014: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/25356132/listeria-infection-in-chinese-pregnant-women-and-neonates-from-shandong
#9
Jun Lv, Zhenli Qin, Yanhua Xu, Qiurong Xie
OBJECTIVE: This study aims to investigate the characters of pregnant women and neonates with listeria monocytogenes infections (L. monocytogenes) in Shandong of China. METHOD: Pregnant women with premature delivery or prenatal fever were recruited in 2013. Bacterial culture was performed for the umbilical cord blood and placental swab after delivery. The strains isolated were then analyzed for the virulence factors and classified based on the serotype and MLST typing...
2014: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/25306879/pregnancy-related-listeriosis-in-france-1984-to-2011-with-a-focus-on-606-cases-from-1999-to-2011
#10
D Girard, A Leclercq, E Laurent, M Lecuit, H de Valk, V Goulet
This study describes trends in the incidence of pregnancy-related listeriosis in France between 1984 and 2011, and presents the major characteristics of 606 cases reported between 1999 and 2011 to the French Institute for Public Health Surveillance through the mandatory notification system. The incidence of pregnancy-related listeriosis decreased by a factor of 12 from 1984 to 2011. This reduction was a result of progressive implementation of specific Listeria monocytogenes control measures in food production...
2014: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/25098360/management-of-pregnant-women-with-presumptive-exposure-to-listeria-monocytogenes
#11
(no author information available yet)
: Listeriosis is predominantly a foodborne illness, with sporadic and outbreak-related cases tied to consumption of food contaminated with listeria (Listeria monocytogenes). The incidence of listeriosis associated with pregnancy is approximately 13 times higher than in the general population. Maternal infection may present as a nonspecific, flu-like illness with fever, myalgia, backache, and headache, often preceded by diarrhea or other gastrointestinal symptoms. However, fetal and neonatal infections can be severe, leading to fetal loss, preterm labor, neonatal sepsis, meningitis, and death...
August 5, 2014: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/25098106/-neonatal-bacteremia-frequency-spectrum-of-organisms-and-correlation-between-clinical-symptoms-and-laboratory-data-for-early-onset-sepsis
#12
L Vakrilova, St Hitrova, E Shopova, R Rousseva, A Radulova, A Masseva
UNLABELLED: Improved obstetrical management and evidence-based peripartum antimicrobial therapy in the last decades reduce the frequency of early-onset neonatal sepsis (EONS) and improve the outcome. The spectrum of the microrganisms is different according to regions, countries and periods of time. Appropriate diagnosis and treatment improve the outcome. However dissociation often occurs between clinical manifestation, laboratory and microbiological findings. AIMS: To determine the incidence of neonatal bacteremia in our hospital, to identify the spectrum of organisms from positive blood cultures (BC), to analyze the correlation between clinical manifestation of EOS and/or laboratory abnormalities...
2014: Akusherstvo i Ginekologii︠a︡
https://www.readbyqxmd.com/read/25060681/systemic-listeria-monocytogenes-infection-in-a-2-year-old-immunocompetent-child
#13
D Lobotková, E Dická, V Rolný, I Stankovič, P Čižnár
Central nervous system infection and sepsis are the most frequently observed clinical presentations of listeriosis infection; however, they are rare in immunocompetent children beyond the neonatal period. In the presented case, we described gastrointestinal involvement, subacute meningitis, sinusitis and sepsis in a two-year-old previously healthy child with acute infection caused by Listeria monocytogenes. We suggest that the infection was probably enhanced by an inappropriate corticosteroid treatment at the onset of the disease, while immunological testing did not confirm the primary deficiency of cellular immunity...
December 2014: Infection
https://www.readbyqxmd.com/read/24997051/incidence-etiology-and-outcome-of-bacterial-meningitis-in-infants-aged-90-days-in-the-united-kingdom-and-republic-of-ireland-prospective-enhanced-national-population-based-surveillance
#14
Ifeanyichukwu O Okike, Alan P Johnson, Katherine L Henderson, Ruth M Blackburn, Berit Muller-Pebody, Shamez N Ladhani, Mark Anthony, Nelly Ninis, Paul T Heath
BACKGROUND: Bacterial meningitis remains a major cause of morbidity and mortality in young infants. Understanding the epidemiology and burden of disease is important. METHODS: Prospective, enhanced, national population-based active surveillance was undertaken to determine the incidence, etiology, and outcome of bacterial meningitis in infants aged <90 days in the United Kingdom and Ireland. RESULTS: During July 2010-July 2011, 364 cases were identified (annual incidence, 0...
November 15, 2014: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/24973315/pregnancy-associated-listeriosis-clinical-characteristics-and-geospatial-analysis-of-a-10-year-period-in-israel
#15
Hila Elinav, Anat Hershko-Klement, Lea Valinsky, Josef Jaffe, Anat Wiseman, Hila Shimon, Eyal Braun, Yossi Paitan, Colin Block, Rotem Sorek, Ran Nir-Paz
BACKGROUND: Listeria monocytogenes is a foodborne pathogen that causes life-threatening infections in elderly, immunocompromised, and pregnant women. In pregnancy it may cause fetal loss or a preterm delivery, and the neonate is prone to neonatal sepsis and death. METHODS: We created a cohort of all L. monocytogenes cases during 10 years (1998-2007) in Israel, by a comprehensive review of cases in hospitals throughout the country and cases reported to the Ministry of Health...
October 2014: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/24911893/enhanced-survival-during-experimental-listeria-monocytogenes-sepsis-in-neonatal-mice-prophylactically-treated-with-th1-and-macrophage-immunoregulatory-cytokines-and-mediators
#16
Mark B Geyer, Kavita Radhakrishnan, Carmella Van de Ven, Mandhir S Suri, Janet Ayello, Mitchell S Cairo
BACKGROUND: Impairments in T-cell and macrophage-mediated host defense lead to increased infection-related morbidity and mortality in neonates, partly because of immaturity in T helper (Th)1 function. Listeria monocytogenes (Lm) is an intracellular pathogen disproportionately causing severe disease among neonates and the immunocompromised. Intact macrophage and Th1-mediated immune responses are critical for Lm clearance. We and others have previously demonstrated downregulation of Th1 and macrophage immunoregulatory cytokines in cord blood versus adult peripheral blood...
December 2014: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/24836302/-listeriosis-and-pregnancy
#17
REVIEW
Caroline Charlier-Woerther, Marc Lecuit
Listeria monocytogenes is a ubiquitous Gram-positive bacillus widespread in nature. It is responsible for febrile abortion and encephalitis in cattle. It survives and multiplies at 4°C and does not alter the taste of food. Listeria monocytogenes is able to cross 3 host barriers: the intestinal, blood-brain and placental barriers. Maternal infection is rare but still severe in France, with 30 to 50 annual cases. Maternal infection is frequently asymptomatic, or manifests as isolated fever, whereas fetal and neonatal infection is severe and have a poor prognosis, with up to 25-35 % fetal/neonatal mortality...
June 2014: La Presse Médicale
https://www.readbyqxmd.com/read/24834711/-listeriosis-in-pregnancy-case-report
#18
Magdalena Barlik, Agnieszka Seremak-Mrozikiewicz, Krzysztof Drews
Listeriosis is a rather rare infectious disease but its incidence in pregnancy is over 20 times higher than in the general population. Pregnant women with listeriosis comprise one-third of all listeriosis cases. Listeriosis is a foodborne disease. Sporadic as well as epidemic cases of listeriosis are usually related to contaminated processed food, especially meat dishes served in fast-food restaurants and dairy products. Pregnant women are at an increased risk for listeriosis infection. Unfortunately the symptoms are not specific and the diagnosis presents a considerable challenge...
April 2014: Ginekologia Polska
https://www.readbyqxmd.com/read/24695762/liofilchem-%C3%A2-o-a-listeria-agar-and-direct-camp-test-provided-sooner-listeria-monocytogenes-identification-from-neonatal-bacteremia
#19
Vincenzo Savini, Roberta Marrollo, Annalisa Serio, Antonello Paparella, Angela Valentina Argentieri, Marianna D'Antonio, Eleonora Coclite, Paola Fusilli, Paolo Fazii
Listeria monocytogenes infection in pregnant women and newborns is a cause for serious concern, and invasive disease outcome strongly depends on prompt antibiotic therapy. To provide sooner identification from neonatal bacteremia we performed a CAMP test directly on positive blood aliquots and inoculated the Liofilchem(®) O.A. Listeria chromogenic agar as well, thus providing a 24-h turn-around time for response.
2014: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/24669144/pigmented-hypopyon-in-association-with-listeria-monocytogenes-endopthalmitis-an-interesting-case-report-following-refractive-surgery-procedure-with-literature-review
#20
REVIEW
Hind M Alkatan, Hassan A Al-Dhibi, Deepak P Edward, Ali A Al-Rajhi
PURPOSE: Listeria monocytogenes is an aerobic, motile, gram positive bacillus recognized as an intercellular pathogen in human where it most frequently affects neonates, pregnant women, elderly patients, and immunosuppressed individuals as well as healthy persons. Ocular listeriosis is rare, most frequently in the form of conjunctivitis, but has been also shown to cause rarely endophthalmitis with pigmented hypopyon and elevated intraocular pressure such as in our case. MATERIALS AND METHODS: We are reporting one immunocompetent patient presenting with dark hypopyon following laser refractive procedure...
January 2014: Middle East African Journal of Ophthalmology
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