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Nirit Kronenfeld, Tomer Ziv Baran, Maya Berlin, Nour Karra, Natalie Dinavitser, Rana Cohen, Yifat Wiener, Eyal Schwartzberg, Matitiahu Bercovitch
BACKGROUND: Current knowledge regarding chronic use of psychotropic medications during breastfeeding is limited. The objective of this study was to evaluate the long-term effects of psychotropic monotherapy use during lactation on the breastfed infant. MATERIALS AND METHODS: In this prospective study, we followed 280 infants whose mothers contacted the Drug Consultation Center (DCC) at Assaf Harofeh Medical Center between January 2011 and December 2015, seeking information regarding the chronic use of psychotropic medications during lactation...
2018: PloS One
Cristina Sáenz de Miera, Ethan Parr, Robert J Denver
In vivo gene transfer is a powerful tool for investigating protein function and gene regulation in living organisms. Delivery of plasmid DNA to the brain of Xenopus tadpoles by bulk electroporation-mediated (EM) gene transfer can be used to study the effects of ectopic gene expression on development, physiology, and behavior. It can also be used to mark cells for lineage tracing, investigate the in vivo function of gene regulatory elements when linked to a reporter gene, and introduce mutations into the genome of transfected cells, among other applications...
May 16, 2018: Cold Spring Harbor Protocols
Gary A Bishop, Molly J Haugen
The University of Denver has collected on-road fuel specific vehicle emissions measurements in the Chicago area since 1989. This nearly 30 year record illustrates the large reductions in light-duty vehicle tailpipe emissions and the remarkable improvements in emissions control durability to maintain low emissions over increasing periods of time. Since 1989 fuel specific carbon monoxide (CO) emissions have been reduced by an order of magnitude and hydrocarbon (HC) emissions by more than a factor of 20. Nitric oxide (NO) emissions have only been collected since 1997 but have seen reductions of 79%...
May 15, 2018: Environmental Science & Technology
Brik R Zivkovich, David C Mays
Evaluating the impact of urban development on natural ecosystem processes has become an increasingly complex task for planners, environmental scientists, and engineers. As the built environment continues to grow, unregulated nonpoint pollutants from increased human activity and large-scale development severely stress urban streams and lakes resulting in their currently impaired or degraded state. In response, integrated water quality management programs have been adopted to address these unregulated nonpoint pollutants by utilizing best management practices (BMPs) that treat runoff as close to the source as possible...
2018: PloS One
Sumana Venkat, Hao Chen, Alleigh Stahman, Denver Hudson, Paige McGuire, Qinglei Gan, Chenguang Fan
The Escherichia coli isocitrate dehydrogenase (ICDH) is one of the tricarboxylic acid cycle enzymes, playing key roles in energy production and carbon flux regulation. E. coli ICDH was the first bacterial enzyme shown to be regulated by reversible phosphorylation. However, the effect of lysine acetylation on E. coli ICDH, which has no sequence similarity with its counterparts in eukaryotes, is still unclear. Based on previous studies of E. coli acetylome and ICDH crystal structures, eight lysine residues were selected for mutational and kinetic analyses...
May 4, 2018: Journal of Molecular Biology
Reina Doyle, Karen Albright, Laura P Hurley, Catia Chávez, Melanie Stowell, Suzanne Dircksen, Edward P Havranek, Mark Anderson
INTRODUCTION: This study investigated participants' acceptance of a short messaging service (SMS) intervention designed to support asthma management, including suggestions regarding program delivery and message content. METHODS: Individual and group interviews were conducted with patients from a safety-net health care system in Denver, Colorado. Eligible participants were English or Spanish speakers between the ages of 13 and 40 years, with diagnosed persistent asthma...
May 1, 2018: Health Promotion Practice
Emily Hopkins, Steven M Green, Michael Kiemeney, Jason S Haukoos
STUDY OBJECTIVE: Out-of-hospital personnel worldwide calculate the 13-point Glasgow Coma Scale (GCS) score as a routine part of field trauma triage. We wish to independently validate a simpler binary assessment to replace the GCS for this task. METHODS: We analyzed trauma center registries from Loma Linda University Health (2003 to 2015) and Denver Health Medical Center (2009 to 2015) to compare the binary assessment "patient does not follow commands" (ie, GCS motor score <6) with GCS score less than or equal to 13 for the prediction of 5 trauma outcomes: emergency intubation, clinically significant brain injury, need for neurosurgical intervention, Injury Severity Score greater than 15, and mortality...
May 2, 2018: Annals of Emergency Medicine
Javeria Saleem, Rubeena Zakar, Muhammad Z Zakar, Mulugeta Belay, Marion Rowe, Peter M Timms, Robert Scragg, Adrian R Martineau
Background: Vitamin D deficiency is common in children with severe acute malnutrition, in whom it is associated with severe wasting. Ready-to-use therapeutic food (the standard treatment) contains modest amounts of vitamin D that do not reliably correct deficiency. Objective: The aim of this study was to determine whether high-dose oral vitamin D3 enhances weight gain and development in children with uncomplicated severe acute malnutrition. Design: We conducted a randomized placebo-controlled trial of high-dose vitamin D3 supplementation in children aged 6-58 mo with uncomplicated severe acute malnutrition in Pakistan...
May 1, 2018: American Journal of Clinical Nutrition
Minghua Tang, Audrey E Hendricks, Nancy F Krebs
Background: Protein intake from cow milk-based infant formula has been associated with rapid weight gain and increased adiposity, but the effect of protein from complementary foods has not been prospectively evaluated, and the effect of protein from sources other than formula during complementary feeding is not clear. Objective: The aim of this study was to directly compare the effect of protein from 2 common complementary food sources, meat and dairy, on infant growth and weight trajectory...
May 1, 2018: American Journal of Clinical Nutrition
Denver P Linklater, Vladimir A Baulin, Saulius Juodkazis, Elena P Ivanova
Growing interest in the bactericidal effect of graphene and graphene-derived nanomaterials has led to the investigation and effective publication of the bactericidal effects of the substratum, many of which present highly conflicting material. The nature of bacterial cell death on graphene bio-interfaces, therefore, remains poorly understood. Here, we review recent findings on the bactericidal effect of graphene and graphene-derived nanomaterials, and proposed mechanisms of cell inactivation, due to mechanical contact with graphene materials, including lipid extraction, physical damage to membranes and pore formation...
June 6, 2018: Interface Focus
Craig A Sewald, Elena S Kuo, Hana Dansky
Food waste and food insecurity are both significant issues in communities throughout the U.S., including Boulder, Colorado. As much as 40% of the food produced in the U.S. goes uneaten and ends up in landfills. Nearly 13% of people in the Boulder region experience some level of food insecurity. Founded in 2011, Boulder Food Rescue supports community members to create their own food security through a participatory approach to an emergency food system. The organization uses a web-application "robot" to manage a schedule of volunteers...
May 2018: American Journal of Preventive Medicine
Kimishige Ishizaka
It has been a little more than 50 years since we discovered IgE, a key molecule for the allergic response and a target for treating allergies and severe asthma. Here, I trace my career, from the kindling of my interest in immunochemistry to groundbreaking discoveries in the biology and chemistry of immunoglobulins. I describe my service to the broader community of immunologists and my role in shaping departments and research institutes. My course starts in Japan and includes Southern California, Baltimore, and Denver...
April 26, 2018: Annual Review of Immunology
Cullen M Dutmer, Allison M Schiltz, Kristy L Freeman, Matthew J Christie, Juana A Cerna, Seung-Hyun Cho, Ryan T Chartier, Jonathan W Thornburg, Katharine L Hamlington, James L Crooks, Tasha E Fingerlin, David A Schwartz, Andrew H Liu
RATIONALE: Home dampness and mold are associated with asthma severity and exacerbations, but little is known about the nature of these exposures in at-risk children. OBJECTIVES: To test the hypothesis that observed dampness, water damage, and mold in the home are associated with higher exposure to particulate matter less than 10 μm in diameter in a cohort of at-risk children with asthma. METHODS: We performed a pilot study in 8- to 16-year-old children with exacerbation-prone asthma (n = 29; Denver Asthma Panel Study)...
April 2018: Annals of the American Thoracic Society
Jason V Wandiyanto, Denver Linklater, Pallale G Tharushi Perera, Anna Orlowska, Vi Khanh Truong, Helmut Thissen, Shahram Ghanaati, Vladimir Baulin, Russell J Crawford, Saulius Juodkazis, Elena P Ivanova
Titanium is a biocompatible material that is frequently used for making implantable medical devices. Nanoengineering of the surface is the common method for increasing material biocompatibility, and while the nanostructured materials are well-known to represent attractive substrata for eukaryotic cells, very little information has been documented about the interaction between mammalian cells and bactericidal nanostructured surfaces. In this study, we investigated the effect of bactericidal titanium nanostructures on PC12 cell attachment and differentiation&mdash;a cell line which has become a widely used in vitro model to study neuronal differentiation...
April 14, 2018: Materials
Dinendra L Abeyawardhane, Ricardo D Fernández, Cody J Murgas, Denver R Heitger, Ashley K Forney, Madeleine K Crozier, Heather R Lucas
Brain metal dyshomeostasis and altered structural dynamics of the presynaptic protein α-synuclein (αS) are both implicated in the pathology of Parkinson's disease (PD), yet a mechanistic understanding of disease progression in the context of αS structure and metal interactions remains elusive. In this Communication, we detail the influence of iron, a prevalent redox-active brain biometal, on the aggregation propensity and secondary structure of N-terminally acetylated αS (NAc αS), the physiologically relevant form in humans...
April 2, 2018: Journal of the American Chemical Society
Paul Denver, Andrew English, Paula L McClean
Cognitive dysfunction and neuroinflammation are typical in Alzheimer's disease (AD), but are also associated with normal aging, albeit less severely. Insulin resistance in the brain has been demonstrated in AD patients and is thought to be involved in AD pathophysiology. Using 15-18 month-old APP/PS1 mice, this study measured peripheral and central insulin signaling and sensitivity, inflammatory markers in brain and plasma and oxidative stress and synapse density in the brain. Novel object recognition, Morris water maze and reversal water maze tasks were performed to assess cognitive function in aged APP/PS1 mice and wild type littermates...
March 29, 2018: Brain, Behavior, and Immunity
James G Hakim, Midion M Chidzonga, Margaret Z Borok, Kusum J Nathoo, Jonathan Matenga, Edward Havranek, Frances Cowan, Melanie Abas, Eva Aagaard, Susan Connors, Sanele Nkomani, Chiratidzo E Ndhlovu, Antony Matsika, Michele Barry, Thomas B Campbell
BACKGROUND: Sub-Saharan Africa has an inadequate number of health professionals, leading to a reduced capacity to respond to health challenges, including HIV/AIDS. From 2010 to 2015, the Medical Education Partnership Initiative (MEPI)-sponsored by the U.S. Presidents Emergency Plan for AIDS Relief (PEPFAR) and the National Institutes of Health (NIH)-was enthusiastically taken up by the University of Zimbabwe College of Health Sciences (UZCHS) and 12 other sub-Saharan African universities to develop models of training to improve medical education and research capacity...
March 21, 2018: Global Health, Science and Practice
Ewa Gajewska, Magdalena Sobieska, Jerzy Moczko
The aim of the study is to select elements of motor skills assessed at 3 months that provide the best predictive properties for motor development at 9 months. In all children a physiotherapeutic assessment of the quantitative and qualitative development at the age of 3 months was performed in the prone and supine positions, which was presented in previous papers as the quantitative and qualitative assessment sheet of motor development. The neurological examination at the age of 9 months was based on the Denver Development Screening Test II and the evaluation of reflexes, muscle tone (hypotony and hypertony), and symmetry...
March 27, 2018: Human Movement Science
Michala K Stock
Although high accuracy rates have been achieved for adult skeletal sex estimation, it is unclear at what age sexually dimorphic traits of the skull become fully developed and useful in subadults. Four linear distances that capture sexual dimorphism-the nuchal crest, mastoid process, glabella, and mental eminence-were measured in a longitudinal sample of lateral cranial radiographs from 10 males and 10 females in the Denver Growth Study (total n = 190). The age full trait expression was attained was compared to that of dental maturity (i...
March 30, 2018: Journal of Forensic Sciences
Erin Sawicki, Dianne C Barker, Marjorie A Gutman, Ian Caughlan, Marissa Yochelson, George Grob
CONTEXT: In recent years, several states have adopted new regulations concerning nutrition, physical activity, and screen time in early care and education (ECE) settings to help prevent childhood obesity. OBJECTIVE: To disseminate a menu of factors that facilitate and/or impede implementation of obesity prevention regulations in ECE settings. DESIGN: To create the menu, we condensed and categorized factors identified in the literature and through field work by placing them within domains...
March 27, 2018: Journal of Public Health Management and Practice: JPHMP
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