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https://www.readbyqxmd.com/read/28734552/prevalence-and-predictive-value-of-pre-therapeutic-sarcopenia-in-cancer-patients-a-systematic-review
#1
REVIEW
Frédéric Pamoukdjian, Thierry Bouillet, Vincent Lévy, Michael Soussan, Laurent Zelek, Elena Paillaud
BACKGROUND & AIMS: To assess the prevalence of sarcopenia before cancer treatment and its predictive value during the treatment. METHODS: We searched MEDLINE via PubMed for articles published from 2008 to 2016 that reported prospective observational or interventional studies of the prevalence of pre-therapeutic sarcopenia and its consequences in adults with cancer who were 18 years or older. Two independent reviewers selected articles based on titles and/or abstracts before a complete review...
July 13, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28733723/an-individualized-radiation-dose-escalation-trial-in-non-small-cell-lung-cancer-based-on-fdg-pet-imaging
#2
Marie Wanet, Antoine Delor, François-Xavier Hanin, Benoît Ghaye, Aline Van Maanen, Vincent Remouchamps, Christian Clermont, Samuel Goossens, John Aldo Lee, Guillaume Janssens, Anne Bol, Xavier Geets
AIM: The aim of the study was to assess the feasibility of an individualized 18F fluorodeoxyglucose positron emission tomography (FDG-PET)-guided dose escalation boost in non-small cell lung cancer (NSCLC) patients and to assess its impact on local tumor control and toxicity. PATIENTS AND METHODS: A total of 13 patients with stage II-III NSCLC were enrolled to receive a dose of 62.5 Gy in 25 fractions to the CT-based planning target volume (PTV; primary turmor and affected lymph nodes)...
July 21, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28731777/induction-and-maintenance-adjuvant-mitomycin-c-topical-therapy-for-upper-tract-urothelial-carcinoma-tolerability-and-intermediate-term-outcomes
#3
Michael Metcalfe, Gavin Wagenheim, Lianchun Xiao, John Papadopoulos, Neema Navai, John W Davis, Jose A Karam, Ashish M Kamat, Christopher G Wood, Colin P Dinney, Surena F Matin
PURPOSE: Endoscopic management of upper tract urothelial carcinoma (UTUC) is associated with higher recurrences, which could be reduced by application of topical therapy. Adjuvant induction Bacillus Calmette-Guerin has shown inferior outcomes for UTUC compared to bladder cancer, and maintenance regimens for UTUC are unexplored. We report on the efficacy, safety, and tolerability of Mitomycin C (MMC) induction and maintenance adjuvant topical therapy for UTUC. MATERIALS AND METHODS: Patients with UTUC who received adjuvant topical therapy after complete endoscopic control of Ta/T1 tumors were retrospectively reviewed...
July 21, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28728312/the-value-of-computed-tomography-in-preoperative-n-staging-of-early-gastric-cancer-meeting-the-endoscopic-resection-criteria
#4
Su Jin Kim, Tae Un Kim, Cheol Woong Choi, Dae Hwan Kang, Hyung Wook Kim, Su Bum Park, Hyeong Seok Nam, Dae Gon Ryu
Background/Aims: This study evaluated the value of abdominal computed tomography (CT) in preoperative N staging of early gastric cancers (EGCs) within standard and expanded indications of endoscopic resection (ER) and investigated the factors affecting accuracy. Methods: Between March 2009 and March 2016, a total of 268 patients with EGC within the standard and expanded indications of ER underwent preoperative abdominal CT and surgical gastrectomy with lymph node (LN) dissection...
July 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28727543/non-small-cell-lung-cancer-radiogenomics-map-identifies-relationships-between-molecular-and-imaging-phenotypes-with-prognostic-implications
#5
Mu Zhou, Ann Leung, Sebastian Echegaray, Andrew Gentles, Joseph B Shrager, Kristin C Jensen, Gerald J Berry, Sylvia K Plevritis, Daniel L Rubin, Sandy Napel, Olivier Gevaert
Purpose To create a radiogenomic map linking computed tomographic (CT) image features and gene expression profiles generated by RNA sequencing for patients with non-small cell lung cancer (NSCLC). Materials and Methods A cohort of 113 patients with NSCLC diagnosed between April 2008 and September 2014 who had preoperative CT data and tumor tissue available was studied. For each tumor, a thoracic radiologist recorded 87 semantic image features, selected to reflect radiologic characteristics of nodule shape, margin, texture, tumor environment, and overall lung characteristics...
July 20, 2017: Radiology
https://www.readbyqxmd.com/read/28726971/an-environment-for-guideline-based-decision-support-systems-for%C3%A2-outpatients-monitoring
#6
Elisa M Zini, Giordano Lanzola, Paolo Bossi, Silvana Quaglini
OBJECTIVES: We propose an architecture for monitoring outpatients that relies on mobile technologies for acquiring data. The goal is to better control the onset of possible side effects between the scheduled visits at the clinic. METHODS: We analyze the architectural components required to ensure a high level of abstraction from data. Clinical practice guidelines were formalized with Alium, an authoring tool based on the PROforma language, using SNOMED-CT as a terminology standard...
July 19, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28722087/-standardized-diagnosis-and-treatment-of-colorectal-liver-metastasis
#7
Hongwei Yao, Zhongtao Zhang
Colorectal cancer is one of the most common malignancies. The liver is the most common site of distant metastasis, and liver metastasis is the leading cause of death in the patients with colorectal cancer. In recent years, the concept of diagnosis and treatment in colorectal liver metastasis (CLM) and the liver surgery techniques developed rapidly, the standardization of clinical practice elevated obviously, and the survival outcomes of more and more patients were significantly improved. Standardization of diagnosis and treatment in CLM comprised overall assessment of patients' condition and local tumor status based on multidisciplinary team collaboration and then institution of treatment strategy...
July 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28717538/assessment-of-prostate-cancer-with-integrated-ct-perfusion-using-a-sector-wise-approach
#8
Matteo Ferrari, Martin Huellner, Chantal Pauli, Burkhardt Seifert, Hansjörg Danuser, Patrick Veit-Haibach, Agostino Mattei
OBJECTIVE: The role of computed tomography perfusion (CTP) in characterizing primary prostate cancer (PCa) is not definitely known. The aim of the present study was to investigate the relationship between CTP parameters and histopathological features of PCa tissue, using a sector-wise approach. MATERIAL AND METHODS: Fifty-one patients with biopsy-proven PCa underwent prospectively a CTP scan prior to radical prostatectomy. Blood flow (BF), mean blood volume (BV) and mean transit time (MTT) were calculated, with the prostate being divided into eight sectors...
June 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28715720/extreme-dilatation-of-the-interposed-jejunal-pouch-after-proximal-gastrectomy-associated-with-portal-venous-gas-a-case-report
#9
Michinaga Takahashi, Shinji Goto, Tatsuya Ueno, Kentaro Shima, Koetsu Inoue, Daisuke Douchi, Orie Nishina, Hiroo Naito
INTRODUCTION: The jejunal pouch interposition (JPI) after proximal gastrectomy (PG) was proposed as a reconstructive procedure to provide a gastric reservoir substitute and prevent postgastrectomy syndrome. However, food residue remaining in some of the pouches resulted in the adverse effect of abdominal bloating, thereby body weight loss. Here, we report a rare case with an extreme dilation of the interposed jejunal pouch (JP) 8 years after PG, requiring pouch resection. PRESENTATION OF CASE: A 65-year-old-man who had undergone PG with an inverted U-shaped JPI for early gastric cancer 8 years previously, suffered from shock after right hip joint implantation...
July 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28712702/clinical-usefulness-of-f-18-fdg-pet-in-lymphoepithelioma-like-gastric-carcinoma
#10
Soyeon Park, Dakeun Lee, Kee Myung Lee, Sang-Uk Han, Jei Hee Lee, Su Jin Lee, Young-Sil An, Joon-Kee Yoon
PURPOSE: Lymphoepithelioma-like carcinoma (LELC) is a rare type of gastric cancer. We evaluated the clinical usefulness of F-18 FDG positron emission tomography/computed tomography (PET/CT) in LELC of stomach. MATERIALS AND METHODS: A total of 28 patients (mean age=59years) who underwent preoperative F-18 FDG PET/CT were enrolled retrospectively. Nine patients underwent follow-up F-18 FDG PET/CT. Pathologic information was obtained through gastrectomy and the association with Epstein-Barr virus (EBV) was investigated in 26 patients...
June 27, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28712119/circulating-activin-a-predicts-survival-in-cancer-patients
#11
Audrey Loumaye, Marie de Barsy, Maxime Nachit, Pascale Lause, Aline van Maanen, Pierre Trefois, Damien Gruson, Jean-Paul Thissen
BACKGROUND: Several experimental evidences pinpoint the possible role of Activin A (ActA) as a driver of cancer cachexia. Supporting this hypothesis, we showed recently that human cancer cachexia is associated with high ActA levels. Moreover, ActA levels were correlated with body weight loss and skeletal muscle density, two prognostic factors in cancer patients. Our goal was therefore to investigate the value of ActA to predict survival in cancer patients. METHODS: Patients with colorectal or lung cancer were prospectively enrolled at the time of diagnosis or relapse between January 2012 and March 2014...
July 15, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28711994/-18-f-fdg-pet-ct-features-for-the-molecular-characterization-of-primary-breast-tumors
#12
Lidija Antunovic, Francesca Gallivanone, Martina Sollini, Andrea Sagona, Alessandra Invento, Giulia Manfrinato, Margarita Kirienko, Corrado Tinterri, Arturo Chiti, Isabella Castiglioni
PURPOSE: The aim of this study was to evaluate the role of imaging features derived from [(18)F]FDG-PET/CT to provide in vivo characterization of breast cancer (BC). METHODS: Images from 43 patients with a first diagnosis of BC were reviewed. Images were acquired before any treatment. Histological data were derived from pretreatment biopsy or surgical histological specimen; these included tumor type, grade, ER and PgR receptor status, lymphovascular invasion, Ki67 index, HER2 status, and molecular subtype...
July 15, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28709441/mortality-outcomes-of-low-dose-computed-tomography-screening-for-lung-cancer-in-urban-china-a-decision-analysis-and-implications-for-practice
#13
Zixing Wang, Wei Han, Weiwei Zhang, Fang Xue, Yuyan Wang, Yaoda Hu, Lei Wang, Chunwu Zhou, Yao Huang, Shijun Zhao, Wei Song, Xin Sui, Ruihong Shi, Jingmei Jiang
BACKGROUND: Mortality outcomes in trials of low-dose computed tomography (CT) screening for lung cancer are inconsistent. This study aimed to evaluate whether CT screening in urban areas of China could reduce lung cancer mortality and to investigate the factors that associate with the screening effect. METHODS: A decision tree model with three scenarios (low-dose CT screening, chest X-ray screening, and no screening) was developed to compare screening results in a simulated Chinese urban cohort (100,000 smokers aged 45-80 years)...
July 14, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28705553/long-term-outcomes-after-pancreaticoduodenectomy-using-pair-watch-suturing-technique-different-roles-of-pancreatic-duct-dilatation-and-remnant-pancreatic-volume-for-the-development-of-pancreatic-endocrine-and-exocrine-dysfunction
#14
Yusuke Iizawa, Hiroyuki Kato, Masashi Kishiwada, Aoi Hayasaki, Akihiro Tanemura, Yasuhiro Murata, Yoshinori Azumi, Naohisa Kuriyama, Shugo Mizuno, Masanobu Usui, Hiroyuki Sakurai, Shuji Isaji
BACKGROUND: We evaluated long-term outcomes including endo- and exocrine functions after pancreaticoduodenectomy (PD) with standardized pancreaticojejunostomy, paying attention to postoperative pancreatic duct dilatation (PDD) and remnant pancreatic volume (RPV), and examined whether postoperative pancreatic fistula (POPF) influenced the configuration of remnant pancreas. METHODS: We analyzed the records of 187 patients with PD who could have RPV measured by CT volumetry at 1 month after operation and had been followed for more than 6 months...
June 23, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28702405/the-impact-of-irradiation-dose-on-the-computed-tomography-radiographic-response-of-metastatic-nodes-and-clinical-outcomes-in-cervix-cancer-in-a-low-resource-setting
#15
Matthew Ryan McKeever, Lindsay Hwang, Jennifer Barclay, Yin Xi, April Bailey, Kevin Albuquerque
INTRODUCTION: The aim of this study is to investigate the relationship between the radiation dose to pelvic and para-aortic lymph nodes, nodal response, and clinical outcomes in a resource-poor setting based on computed tomography (CT) nodal size alone. MATERIALS AND METHODS: This retrospective study from 2009 to 2015 included 46 cervical cancer patients with 133 metastatic pelvic and para-aortic lymph nodes definitively treated with chemoradiation and brachytherapy in a public hospital with limited access to positron emission tomography (PET) scans...
April 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28698537/positron-emission-tomography-computed-tomography-pet-ct-and-ct-for-n-staging-of-non-small-cell-lung-cancer
#16
Sandra Vegar Zubović, Spomenka Kristić, Besima Hadžihasanović
Aim The aim of this study is to investigate the possibilities of non-invasive diagnostic imaging methods, positron emission tomography/computed tomography (PET/CT) and CT, in clinical N staging of non-small cell lung cancer (NSCLC). Methods Retrospective clinical study included 50 patients with diagnosed NSCLC who have undergone PET/CT for the purpose of disease staging. The International association for the study of lung cancer (IASLC) nodal mapping system was used for analysis of nodal disease. Data regarding CT N-staging and PET/CT Nstaging were recorded...
August 1, 2017: Medicinski Glasnik
https://www.readbyqxmd.com/read/28697193/the-value-of-18-fdg-pet-ct-parameters-hematological-parameters-and-tumor-markers-in-predicting-kras-oncogene-mutation-in-colorectal-cancer
#17
Ali Ozan Oner, Evrim Surer Budak, Senay Yıldırım, Funda Aydın, Cem Sezer
OBJECTIVE: In this study we investigated the predictive value of maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), neutrophils/lymphocytes ratio (NLR), platelets/lymphocytes ratio (PLR), carcinoembryonic antigen (CEA) and carbohydrate antigen (CA 19-9) in the prediction of KRAS gene mutation which plays an important role in the choice of treatment in colorectal cancer patients. SUBJECTS AND METHODS: A total of 55 cases with untreated colorectal cancer who had undergone both PET/CT examinations for initial staging and also mutation analysis of KRAS oncogene were studied...
July 12, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28696897/polymorphisms-of-xenobiotic-metabolizing-enzymes-in-bladder-cancer-patients-of-the-semmelweis-university-budapest-hungary
#18
Dörte Ebbinghaus, Gergely Bánfi, Silvia Selinski, Meinolf Blaszkewicz, Hannah Bürger, Jan G Hengstler, Péter Nyirády, Klaus Golka
Polymorphic xenobiotic metabolizing enzymes such as N-acetyltransferase 2 (NAT2) or glutathione S-transferase M1 (GSTM1) are known to modulate bladder cancer risk. As no apparent data were available from Hungary, a former member of the eastern European economic organization, a study was performed in Budapest. In total, 182 bladder cancer cases and 78 cancer-free controls were investigated by questionnaire. Genotypes of NAT2, GSTM1, GSTT1, rs1058396 and rs17674580 were determined by standard methods. Current smokers' crude odds ratio (OR) (3...
July 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28696184/insurance-coverage-for-ct-colonography-screening-impact-on-overall-colorectal-cancer-screening-rates
#19
Maureen A Smith, Jennifer M Weiss, Aaron Potvien, Jessica R Schumacher, Ronald E Gangnon, David H Kim, Lauren A Weeth-Feinstein, Perry J Pickhardt
Purpose To compare overall colorectal cancer (CRC) screening rates for patients who were eligible and due for CRC screening and who were with and without insurance coverage for computed tomographic (CT) colonography for CRC screening. Materials and Methods The institutional review board approved this retrospective cohort study, with a waiver of consent. This study used longitudinal electronic health record data from 2005 through 2010 for patients managed by one of the largest multispecialty physician groups in the United States...
July 11, 2017: Radiology
https://www.readbyqxmd.com/read/28694742/clinical-validation-of-a-blood-based-classifier-for-diagnostic-evaluation-of-asymptomatic-individuals-with-pulmonary-nodules
#20
Charles E Birse, Jennifer L Tomic, Harvey I Pass, William N Rom, Robert J Lagier
BACKGROUND: The number of pulmonary nodules detected in the US is expected to increase substantially following recent recommendations for nationwide CT-based lung cancer screening. Given the low specificity of CT screening, non-invasive adjuvant methods are needed to differentiate cancerous lesions from benign nodules to help avoid unnecessary invasive procedures in the asymptomatic population. We have constructed a serum-based multi-biomarker panel and assessed its clinical accuracy in a retrospective analysis of samples collected from participants with suspicious radiographic findings in the Prostate, Lung, Chest and Ovarian (PLCO) cancer screening trial...
2017: Clinical Proteomics
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