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https://www.readbyqxmd.com/read/28213789/a-novel-prognostic-scoring-system-based-on-preoperative-sarcopenia-predicts-the-long-term-outcome-for-patients-after-r0-resection-for-gastric-cancer-experiences-of-a-high-volume-center
#1
Zhi-Fang Zheng, Jun Lu, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Mi Lin, Chang-Ming Huang
BACKGROUND: The relationship between sarcopenia and prognosis of gastric cancer (GC) is unclear. This study aimed to develop a prognostic scoring system combining sarcopenia with preoperative clinical parameters for patients with GC to predict 3-year overall survival (OS) and 3-year recurrence-free survival (RFS). METHODS: In this study, 924 patients with GC who underwent radical gastrectomy were retrospectively analyzed. The data were divided into a training set and a validation set...
February 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28213008/the-prognostic-impact-of-tumor-volume-on-stage-i-non-small-cell-lung-cancer
#2
Xiao-Dong Su, Hao-Jun Xie, Qian-Wen Liu, Yun-Xian Mo, Hao Long, Tie-Hua Rong
OBJECTIVES: The purpose of this study was to investigate the prognostic impact of tumor volume (TV) on patients with stage I non-small cell lung cancer (NSCLC) after complete resection. MATERIALS AND METHODS: We retrospectively reviewed the clinicopathological characteristics of 274 patients with stage I NSCLC who had received preoperative chest computed tomography (CT) scans and complete resection. TV was semi-automatically measured from chest CT scans by using an imaging software program...
February 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28212991/different-histological-subtypes-of-peripheral-lung-cancer-based-on-emphysema-distribution-in-patients-with-both-airflow-limitation-and-ct-determined-emphysema
#3
Beomsu Shin, Sumin Shin, Myung Jin Chung, Hyun Lee, Won-Jung Koh, Hojoong Kim, Hye Yun Park
The histological subtypes by peripheral tumor location remain uncharacterized in COPD patients with emphysema. We investigated histologic subtypes of peripheral lung cancers based on the context of heterogeneous emphysema distribution in patients with airflow limitation and CT-determined emphysema. A retrospective, cross-sectional study was conducted using data from 754 patients with airflow limitation and newly-diagnosed primary lung cancers from February 2013 to February 2015. Of these, 230 patients had emphysema, as determined by computed tomography software designed to quantify emphysema...
February 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28211937/patterns-of-computed-tomography-surveillance-in-survivors-of-colorectal-cancer-at-veterans-health-administration-facilities
#4
Amikar Sehdev, Eric A Sherer, Siu L Hui, Jingwei Wu, David A Haggstrom
BACKGROUND: Annual computed tomography (CT) scans are a component of the current standard of care for the posttreatment surveillance of survivors of colorectal cancer (CRC) after curative-intent resection. The authors conducted a retrospective study with the primary aim of assessing patient, physician, and organizational characteristics associated with the receipt of CT surveillance among veterans. METHODS: The Department of Veterans Affairs Central Cancer Registry was used to identify patients diagnosed with AJCC collaborative stage I to III CRC between 2001 and 2009...
February 17, 2017: Cancer
https://www.readbyqxmd.com/read/28210997/3d-skeletal-uptake-of-18-f-sodium-fluoride-in-pet-ct-images-is-associated-with-overall-survival-in-patients-with-prostate-cancer
#5
Sarah Lindgren Belal, May Sadik, Reza Kaboteh, Nezar Hasani, Olof Enqvist, Linus Svärm, Fredrik Kahl, Jane Simonsen, Mads H Poulsen, Mattias Ohlsson, Poul F Høilund-Carlsen, Lars Edenbrandt, Elin Trägårdh
BACKGROUND: Sodium fluoride (NaF) positron emission tomography combined with computer tomography (PET/CT) has shown to be more sensitive than the whole-body bone scan in the detection of skeletal uptake due to metastases in prostate cancer. We aimed to calculate a 3D index for NaF PET/CT and investigate its correlation to the bone scan index (BSI) and overall survival (OS) in a group of patients with prostate cancer. METHODS: NaF PET/CT and bone scans were studied in 48 patients with prostate cancer...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28210538/patient-and-primary-care-provider-attitudes-and-adherence-towards-lung-cancer-screening-at-an-academic-medical-center
#6
Duy K Duong, Salma Shariff-Marco, Iona Cheng, Harris Naemi, Lisa M Moy, Robert Haile, Baldeep Singh, Ann Leung, Ann Hsing, Viswam S Nair
Low dose CT (LDCT) for lung cancer screening is an evidence-based, guideline recommended, and Medicare approved test but uptake requires further study. We therefore conducted patient and provider surveys to elucidate factors associated with utilization. Patients referred for LDCT at an academic medical center were questioned about their attitudes, knowledge, and beliefs on lung cancer screening. Adherent patients were defined as those who met screening eligibility criteria and completed a LDCT. Referring primary care providers within this same medical system were surveyed in parallel about their practice patterns, attitudes, knowledge and beliefs about screening...
June 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28209912/detection-efficacy-of-hybrid-68-ga-psma-ligand-pet-ct-in-prostate-cancer-patients-with-biochemical-recurrence-after-primary-radiation-therapy-defined-by-phoenix-criteria
#7
Ingo Einspieler, Isabel Rauscher, Charlotte Düwel, Markus Krönke, Christoph Rischpler, Gregor Habl, Sabrina Dewes, Armin Ott, Hans-Jürgen Wester, Markus Schwaiger, Tobias Maurer, Matthias Eiber
The aim of this retrospective study was to evaluate the detection rate of Glu-NH-CO-NH-Lys-(Ahx)-[(68)Ga(HBED-CC)] ((68)Ga-PSMA ligand) positron emission tomography/computed tomography (PET/CT) in patients with biochemical recurrent prostate cancer (PC) defined by Phoenix criteria after external beam radiotherapy (EBRT) or brachytherapy as primary treatment. Methods: 118 patients were finally eligible for this retrospective analysis with a median prostate-specific antigen (PSA) of 6.4 ng/mL (range: 2.2-158...
February 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28209203/crizotinib-associated-renal-cysts-carcs-incidence-and-patterns-of-evolution
#8
Laird B Cameron, Damian H S Jiang, Kate Moodie, Catherine Mitchell, Benjamin Solomon, Bimal Kumar Parameswaran
BACKGROUND: Novel therapeutic agents recently introduced for the treatment of cancer have several unusual side effects. An increased incidence of renal cystic lesions, often with features concerning for malignancy or infection, has been reported in patients with anaplastic lymphoma kinase (ALK) - rearranged advanced non-small cell lung cancer (NSCLC) treated with Crizotinib. Many of these lesions undergo spontaneous resolution despite developing complex features on imaging. We assess the incidence and patterns of evolution of Crizotinib Associated Renal Cysts [CARCs] at our institute and provide histopathology correlation of their benign nature...
February 16, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/28207541/examination-of-a-crp-first-approach-for-the-detection-of-postoperative-complications-in-patients-undergoing-surgery-for-colorectal-cancer-a-pragmatic-study
#9
Stephen T McSorley, Bo Y Khor, Graham J MacKay, Paul G Horgan, Donald C McMillan
The aim of the present study was to examine whether a C-reactive protein (CRP) first approach would improve the detection rate of postoperative complications by CT.CRP is a useful biomarker to identify major complications following surgery for colorectal cancer.Patients with histologically confirmed colorectal cancer, who underwent elective surgery between 2008 and 2015 at a single centre were included. Exceeding the established CRP threshold of 150 mg/L on postoperative day (POD) 4 was recorded. Results of CT performed between postoperative days 4 and 14 were recorded...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28205231/analysis-of-ctdna-to-predict-prognosis-and-monitor-treatment-responses-in-metastatic-pancreatic-cancer-patients
#10
He Cheng, Chen Liu, Jiahao Jiang, Guopei Luo, Yu Lu, Kaizhou Jin, Meng Guo, Zhenzhen Zhang, Jin Xu, Liang Liu, Quanxing Ni, Xianjun Yu
Cell-free circulating tumor DNA (ctDNA) in plasma has been used as a potential noninvasive biomarker for various tumors. The current study was performed to evaluate the clinical implications of ctDNA detection in patients with metastatic pancreatic cancer. Firstly, we attempted to prospectively screen a panel of 60 genes in cell-free DNA (cfDNA) from ten metastatic pancreatic cancer patients via exome sequencing. Secondly, droplet digital PCR (ddPCR) was used to identify potential mutations in a cohort of 188 patients with metastatic pancreatic cancer...
February 16, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28198519/correlation-of-hypoxia-inducible-transcription-factor-in-breast-cancer-and-suvmax-of-f-18-fdg-pet-ct
#11
Young-Ju Jeong, Jae-Won Jung, Yoon-Young Cho, Sung-Hwan Park, Hoon-Kyu Oh, Sungmin Kang
BACKGROUND: Tumor hypoxia induces the expression of several genes via the hypoxia-inducible transcription factor-1 alpha (HIF-1a). It is associated with the prognosis of several cancers. We studied the immunohistochemical expression of HIF-1a in patients with invasive ductal cancer (IDC) of the breast and the possible correlation with the maximum standardized uptake value of the primary tumor (pSUVmax) as well as other biological parameters. Prognostic significance of pSUVmax and expression of HIF-1a for the prediction of progression-free survival (PFS) was also assessed...
2017: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/28196352/risk-factor-of-pancreatic-fistula-after-radical-gastrectomy-in-the-context-of-fatty-pancreas
#12
Yuya Sato, Mikito Inokuchi, Sho Otsuki, Yoshitaka Fujimori, Kazuyuki Kojima
BACKGROUND: We suspected that fatty pancreas, accompanied with metabolic syndrome, may be associated with the incidence of postoperative pancreatic fistula (POPF) after radial gastrectomy. METHODS: Between February 2012 and March 2014, we reviewed consecutive 79 gastric cancer patients who underwent radical gastrectomy. To quantify the degree of fatty infiltration to pancreas by preoperative contrast-enhanced CT, we measured ratios and differences between pancreatic and splenic attenuation values (P/S and P-S, respectively)...
February 15, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28195905/value-of-intratumoral-metabolic-heterogeneity-and-quantitative-18f-fdg-pet-ct-parameters-to-predict-prognosis-in-patients-with-hpv-positive-primary-oropharyngeal-squamous-cell-carcinoma
#13
Esther Mena, Mehdi Taghipour, Sara Sheikhbahaei, Abhinav K Jha, Arman Rahmim, Lilja Solnes, Rathan M Subramaniam
OBJECTIVE: The aim of this study was to evaluate the impact of intratumoral metabolic heterogeneity and quantitative FDG PET/CT imaging parameters for predicting patient outcomes in primary oropharyngeal squamous cell cancer (OPSCC). PATIENTS AND METHODS: We retrospectively investigated 105 patients with HPV-positive OPSCC. SUVmax and metabolic tumor volume (MTV) were measured for the primary tumors and when available for the metastatic sites. Primary tumor intratumoral metabolic heterogeneity was calculated as the area under a cumulative SUV volume histograms curve (AUC-CSH)...
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28194522/a-prospective-multi-institutional-validity-study-to-evaluate-the-accuracy-of-clinical-diagnosis-of-pathological-stage-iii-gastric-cancer-jcog1302a
#14
Takeo Fukagawa, Hitoshi Katai, Junki Mizusawa, Kenichi Nakamura, Takeshi Sano, Masanori Terashima, Seiji Ito, Takaki Yoshikawa, Norimasa Fukushima, Yasuyuki Kawachi, Takahiro Kinoshita, Yutaka Kimura, Hiroshi Yabusaki, Yasunori Nishida, Yoshiaki Iwasaki, Sang-Woong Lee, Takashi Yasuda, Mitsuru Sasako
BACKGROUND: Neoadjuvant chemotherapy (NAC) followed by radical surgery is a promising strategy to improve survival of patients with stage III gastric cancer, but is associated with the risk of preoperative overdiagnosis by which patients with early disease may receive unnecessary intensive chemotherapy. METHODS: We assessed the validity of a preoperative diagnostic criterion in a prospective multicenter study. Patients with gastric cancer with a clinical diagnosis of T2/T3/T4, M0, except for diffuse large tumors and extensive bulky nodal disease, were eligible...
February 13, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28194229/circulating-and-tissue-biomarkers-in-early-stage-non-small-cell-lung-cancer
#15
Caterina Fumagalli, Fabrizio Bianchi, Paola Rafaniello Raviele, Davide Vacirca, Giovanni Bertalot, Cristiano Rampinelli, Matteo Lazzeroni, Bernardo Bonanni, Giulia Veronesi, Nicola Fusco, Massimo Barberis, Elena Guerini-Rocco
OBJECTIVE: We sought to characterise circulating and tissue tumour biomarkers of patients who developed early-stage non-small cell lung cancer (NSCLC) during long-term follow-up of a chemoprevention trial (NCT00321893). MATERIALS AND METHODS: Blood and sputum samples were collected from 202 high-risk asymptomatic individuals with CT-detected stable lung nodules. Real-time PCR was performed on plasma to quantify free circulating DNA. Baseline serum was investigated with a previously validated test based on 13 circulating miRNAs (miR-Test)...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28193644/tumour-thrombus-of-the-inferior-vena-cava-extending-into-the-right-atrium-in-the-setting-of-colon-cancer
#16
Daniel Meyers, Nancy A Nixon, Angela Franko, Danny Ng, Vincent C Tam
Tumour thrombus is seen in renal cell and hepatocellular carcinoma, but is rarely reported in colorectal cancer. A woman aged 46 years, with metastatic colonic adenocarcinoma, was found to have a large mass in the inferior vena cava (IVC) extending into the right atrium. Although this lesion was initially thought to be bland thrombus, imaging with contrast-enhanced CT scan and contrast-enhanced ultrasound supported the diagnosis of tumour thrombus. Despite the large size of the lesion, the patient was asymptomatic...
February 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28192888/computed-tomography-morphologic-features-of-pulmonary-adenocarcinoma-with-brain-bone-metastasis
#17
Ki-Eun Hwang, Su-Jin Oh, Chul Park, Se-Jeong Jeon, Jeong-Mi Lee, Byong-Ki Cha, Kwon-Ha Yoon, Eun-Taik Jeong, Hak-Ryul Kim
Background/Aims: Brain and bone metastases are common in patients with lung cancer. The development of metastasis is associated with poor survival in lung cancer patients. Although tumor morphologic features on radiographs are routinely assessed for differentiation between benign and malignant lung nodules, they are not used to predict metastasis. We assessed morphologic features of pulmonary adenocarcinomas with brain/bone metastasis on computed tomography (CT) to identify related factors for metastasis...
February 15, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28191357/metastatic-invasive-lobular-breast-cancer-presenting-clinically-with-esophageal-dysphagia
#18
Lilit Karapetyan, Heather Laird-Fick, Reuben Cuison
Background. Intra-abdominal metastases of invasive lobular breast cancer (ILBC) may be insidious. We report a case of metastatic ILBC that presented with dysphagia within weeks of a negative mammogram and before the development of intra-abdominal symptoms. Case. A 70-year-old female developed esophageal dysphagia. She underwent EGD which showed a short segment of stricture of the distal esophagus without significant mucosal changes. Biopsy was unremarkable and patient underwent lower esophageal sphincter (LES) dilation...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/28188016/concurrent-chemoradiotherapy-vs-radiotherapy-alone-in-locally-advanced-cervix-cancer-a-systematic-review-and-meta-analysis
#19
REVIEW
Niloy Ranjan Datta, Emanuel Stutz, Michael Liu, Susanne Rogers, Dirk Klingbiel, Alexander Siebenhüner, Shalini Singh, Stephan Bodis
The efficacy of concurrent chemoradiotherapy (CTRT) in locally advanced cervix cancer (LACC, stages IIB-IVA) is contentious. This is due to the variable extent of therapeutic benefit reported in different randomized clinical trials and meta-analyses that usually include all stages of cervix cancer. A systematic review and meta-analysis was therefore conducted to evaluate the efficacy of concurrent CTRT over radiotherapy (RT) alone, predominantly in LACC for the key endpoints; complete response (CR), long-term loco-regional control (LRC), overall survival (OS), grade III/IV acute and late toxicities...
February 7, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28185344/incidental-and-nonincidental-canine-thyroid-tumors-assessed-by-multidetector-row-computed-tomography-a-single-centre-cross-sectional-study-in-4520-dogs
#20
Giovanna Bertolini, Michele Drigo, Luca Angeloni, Marco Caldin
Thyroid nodules are common in dogs and are increasingly likely to be detected with the increased use of advanced imaging modalities. An unsuspected, nonpalpable, asymptomatic lesion, defined as a thyroid incidentaloma, may be discovered on an imaging study unrelated to the thyroid gland. The objective of this single-center cross-sectional study was to assess the prevalence and computed tomography (CT) characteristics of incidental and nonincidental thyroid tumors in a large population of dogs, using prospective recruitment of patients undergoing CT examination for various reasons during the period of 2005-2015...
February 9, 2017: Veterinary Radiology & Ultrasound
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