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https://www.readbyqxmd.com/read/28075695/lessons-from-launching-the-diabetes-prevention-program-in-a-large-integrated-health-care-delivery-system-a-case-study
#1
Colin D Rehm, Melinda E Marquez, Elizabeth Spurrell-Huss, Nicole Hollingsworth, Amanda S Parsons
There is urgent need for health systems to prevent diabetes. To date, few health systems have implemented the evidence-based Diabetes Prevention Program (DPP), and the few that have mostly partnered with community-based organizations to implement the program. Given the recent decision by the Centers for Medicare & Medicaid Services to reimburse for diabetes prevention, there is likely much interest in how such programs can be implemented within large health systems or how community partnerships can be expanded to support DPP implementation...
January 11, 2017: Population Health Management
https://www.readbyqxmd.com/read/28065902/princess-privacy-protecting-rare-disease-international-network-collaboration-via-encryption-through-software-guard-extensions
#2
Feng Chen, Shuang Wang, Xiaoqian Jiang, Sijie Ding, Yao Lu, Jihoon Kim, S Cenk Sahinalp, Chisato Shimizu, Jane C Burns, Victoria J Wright, Eileen Png, Martin L Hibberd, David D Lloyd, Hai Yang, Amalio Telenti, Cinnamon S Bloss, Dov Fox, Kristin Lauter, Lucila Ohno-Machado
MOTIVATION: We introduce PRINCESS, a privacy-preserving international collaboration framework for analyzing rare disease genetic data that are distributed across different continents. PRINCESS leverages Software Guard Extensions (SGX) and hardware for trustworthy computation. Unlike a traditional international collaboration model, where individual-level patient DNA are physically centralized at a single site, PRINCESS performs a secure and distributed computation over encrypted data, fulfilling institutional policies and regulations for protected health information...
January 8, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28058729/role-of-the-attachment-style-in-determining-the-association-between-headache-features-and-psychological-symptoms-in-migraine-children-and-adolescents-an-analytical-observational-case-control-study
#3
Samuela Tarantino, Cristiana De Ranieri, Cecilia Dionisi, Valentina Gagliardi, Maria Francesca Paniccia, Alessandro Capuano, Roberto Frusciante, Martina Balestri, Federico Vigevano, Simonetta Gentile, Massimiliano Valeriani
OBJECTIVE: We aimed to study the role of attachment style on headache severity and psychological symptoms in migraineurs children/adolescents. Moreover, we investigated the association between attachment style, migraine severity, and psychological symptoms. BACKGROUND: Attachment theory suggests that early interpersonal relationships may be important determinants of psychopathology and pain management. In particular, individuals with insecure attachment styles have been shown to experience more pain than people with secure attachment style...
January 6, 2017: Headache
https://www.readbyqxmd.com/read/28058008/laparoscopic-liver-resection-for-posterosuperior-tumors-using-caudal-approach-and-postural-changes-a-new-technical-approach
#4
EDITORIAL
Zenichi Morise
Laparoscopic liver resection (LLR) for tumors in the posterosuperior liver [segment (S) 7 and deep S6] is a challenging clinical procedure. This area is located in the bottom of the small subphrenic space (rib cage), with the large and heavy right liver on it when the patient is in the supine position. Thus, LLR of this area is technically demanding because of the handling of the right liver which is necessary to obtain a fine surgical view, secure hemostasis and conduct the resection so as to achieve an appropriate surgical margin in the cage...
December 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28049465/secure-and-scalable-deduplication-of-horizontally-partitioned-health-data-for-privacy-preserving-distributed-statistical-computation
#5
Kassaye Yitbarek Yigzaw, Antonis Michalas, Johan Gustav Bellika
BACKGROUND: Techniques have been developed to compute statistics on distributed datasets without revealing private information except the statistical results. However, duplicate records in a distributed dataset may lead to incorrect statistical results. Therefore, to increase the accuracy of the statistical analysis of a distributed dataset, secure deduplication is an important preprocessing step. METHODS: We designed a secure protocol for the deduplication of horizontally partitioned datasets with deterministic record linkage algorithms...
January 3, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28048218/mo-f-204-01-preparing-for-part-1-of-the-abr-diagnostic-physics-exam
#6
S McKenney
: Adequate, efficient preparation for the ABR Diagnostic and Nuclear Medical Physics exams is key to successfully obtain ABR certification. Each part of the ABR exam presents its own challenges: Part I: Determine the scope of basic medical physics study material, efficiently review this material, and solve related written questions/problems. Part II: Understand imaging principles, modalities, and systems, including image acquisition, processing, and display. Understand the relationship between imaging techniques, image quality, patient dose and safety, and solve related written questions/problems...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047325/su-f-t-95-an-automatic-data-verification-method-during-an-eclipse-aria-version-upgrade-using-cryptographic-secure-hash-algorithm
#7
Z Xu, J Baker, S Ryu
PURPOSE: To develop an efficient way to verify that patient plan and dose information does not change during an Eclipse/Aria database version upgrade. METHODS: Eclipse Scripting Application Programming Interface (ESAPI) was used to create a script to retrieve plan information from the Eclipse database before and after the database upgrade for each patient on treatment. Using Cryptographic Secure Hash Algorithm (SHA256), fixed length digest hash values are generated from the plan parameters for each patient...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046750/su-f-j-18-feasibility-of-open-mask-immobilization-with-optical-imaging-guidance-oig-for-h-n-radiotherapy
#8
B Zhao, G Maquilan, M Anders, S Jiang, D Schwartz
PURPOSE: Full face and neck thermoplastic masks provide standard-of-care immobilization for patients receiving H&N IMRT. However, these masks are uncomfortable and increase skin dose. The purpose of this pilot study was to investigate the feasibility and setup accuracy of open face and neck mask immobilization with OIG. METHODS: Ten patients were consented and enrolled to this IRB-approved protocol. Patients were immobilized with open masks securing only forehead and chin...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28032947/controversies-in-the-management-of-caustic-ingestion-injury-an-evidence-based-review
#9
J H Bird, S Kumar, C Paul, J D Ramsden
BACKGROUND: Caustic ingestion of acid or alkaline substances can cause damage to the upper respiratory and upper digestive tract. Initial presentation following caustic ingestion can include oropharyngeal pain, dysphagia and stridor. Due to this clinical presentation that the resident otolaryngologist is consulted to review and examine these patients to assess for airway compromise and commence initial management and care until airway concern has passed. OBJECTIVE OF REVIEW: This review aims to provide evidence based guidance in the management of those presenting with acute ingestion injury so that informed initial medical therapy can be commenced and appropriate investigations arranged to optimise patient outcome...
December 29, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28026055/fertility-preservation-counselling-in-dutch-oncology-practice-are-nurses-ready-to-assist-physicians
#10
E M Krouwel, M P J Nicolai, A Q M J van Steijn-van Tol, H Putter, S Osanto, R C M Pelger, H W Elzevier
Cancer and its treatments may result in impaired fertility, which could cause long-term distress to cancer survivors. For eligible patients, fertility preservation (FP) is available to secure future reproductive potential. Many physicians, however, feel inhibited about discussing FP. Oncology nurses may serve as an initiator for discussing the subject and provide additional support. Our aim was to investigate their knowledge about FP, the way they apply this, and possible barriers to discussing FP with patients of reproductive age...
December 27, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28025919/amcp-partnership-forum-enabling-the-exchange-of-clinical-and-economic-information-pre-fda-approval
#11
(no author information available yet)
: Current federal laws and FDA regulations have significantly restricted the sharing of clinical and health economic information on biopharmaceuticals that have yet to receive FDA approval. Over the past several years, organizations that make health care coverage decisions, including those that set copayments, premiums, and formulary placement, have expressed a need for receiving this information before approval, as long as appropriate safeguards exist to prevent this information from reaching unintended entities...
January 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28008176/trends-in-overall-survival-and-costs-of-multiple-myeloma-2000-2014
#12
R Fonseca, S Abouzaid, M Bonafede, Q Cai, K Parikh, L Cosler, P Richardson
Little real-world evidence is available to describe the recent trends in treatment costs and outcomes for patients with multiple myeloma (MM). Using the Truven Health MarketScan® Research Databases linked with social security administration (SSA) death records, this study found that the percentage of MM patients using novel therapy continuously increased from 8.7% in 2000 to 61.3% in 2014. Compared with MM patients diagnosed in earlier years, those diagnosed after 2010 had higher rates of novel therapy use and better survival outcomes; patients diagnosed in 2012 were 1...
December 23, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28006819/better-resource-utilisation-and-quality-of-care-for-ovarian-cancer-patients-using-internet-based-pathology-review
#13
S Kommoss, F Kommoss, J Diebold, S Lax, D Schmidt, A Staebler, A du Bois, J Pfisterer
BACKGROUND: The current literature indicates that a considerable number of patients in ovarian carcinoma clinical trials have histopathological diagnoses in conflict with inclusion criteria. It has been suggested that specialised pathology review prior to randomisation should become the standard procedure in study protocols. We hypothesised that our new, internet-based high-throughput infrastructure would be capable of providing specialised pathology review within 10 working days (w.d...
December 22, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27995826/patient-staff-and-clinician-perspectives-on-implementing-electronic-communications-in-an-interdisciplinary-rural-family-health-practice
#14
Feng Chang, Thivaher Paramsothy, Matthew Roche, Nishi S Gupta
: Aim To conduct an environmental scan of a rural primary care clinic to assess the feasibility of implementing an e-communications system between patients and clinic staff. BACKGROUND: Increasing demands on healthcare require greater efficiencies in communications and services, particularly in rural areas. E-communications may improve clinic efficiency and delivery of healthcare but raises concerns about patient privacy and data security. METHODS: We conducted an environmental scan at one family health team clinic, a high-volume interdisciplinary primary care practice in rural southwestern Ontario, Canada, to determine the feasibility of implementing an e-communications system between its patients and staff...
December 20, 2016: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/27977068/development-of-a-repository-of-individual-participant-data-from-randomized-controlled-trials-of-therapists-delivered-interventions-for-low-back-pain
#15
S W Hee, M Dritsaki, A Willis, M Underwood, S Patel
BACKGROUND: Individual patient data (IPD) meta-analysis of existing randomized controlled trials (RCTs) is a promising approach to achieving sufficient statistical power to identify sub-groups. We created a repository of IPD from multiple low back pain (LBP) RCTs to facilitate a study of treatment moderators. Due to sparse heterogeneous data, the repository needed to be robust and flexible to accommodate millions of data points prior to any subsequent analysis. METHODS: We systematically identified RCTs of therapist delivered intervention for inclusion to the repository...
December 15, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27942512/treating-the-host-response-to-emerging-virus-diseases-lessons-learned-from-sepsis-pneumonia-influenza-and-ebola
#16
REVIEW
David S Fedson
There is an ongoing threat of epidemic or pandemic diseases that could be caused by influenza, Ebola or other emerging viruses. It will be difficult and costly to develop new drugs that target each of these viruses. Statins and angiotensin receptor blockers (ARBs) have been effective in treating patients with sepsis, pneumonia and influenza, and a statin/ARB combination appeared to dramatically reduce mortality during the recent Ebola outbreak. These drugs target (among other things) the endothelial dysfunction found in all of these diseases...
November 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27939304/pooling-and-expanding-registries-of-familial-hypercholesterolaemia-to-assess-gaps-in-care-and-improve-disease-management-and-outcomes-rationale-and-design-of-the-global-eas-familial-hypercholesterolaemia-studies-collaboration
#17
Antonio J Vallejo-Vaz, Asif Akram, Sreenivasa Rao Kondapally Seshasai, Della Cole, Gerald F Watts, G Kees Hovingh, John J P Kastelein, Pedro Mata, Frederick J Raal, Raul D Santos, Handrean Soran, Tomas Freiberger, Marianne Abifadel, Carlos A Aguilar-Salinas, Fahad Alnouri, Rodrigo Alonso, Khalid Al-Rasadi, Maciej Banach, Martin P Bogsrud, Mafalda Bourbon, Eric Bruckert, Josip Car, Richard Ceska, Pablo Corral, Olivier Descamps, Hans Dieplinger, Can T Do, Ronen Durst, Marat V Ezhov, Zlatko Fras, Dan Gaita, Isabel M Gaspar, Jaques Genest, Mariko Harada-Shiba, Lixin Jiang, Meral Kayikcioglu, Carolyn S P Lam, Gustavs Latkovskis, Ulrich Laufs, Evangelos Liberopoulos, Jie Lin, Nan Lin, Vincent Maher, Nelson Majano, A David Marais, Winfried März, Erkin Mirrakhimov, André R Miserez, Olena Mitchenko, Hapizah Nawawi, Lennart Nilsson, Børge G Nordestgaard, György Paragh, Zaneta Petrulioniene, Belma Pojskic, Željko Reiner, Amirhossein Sahebkar, Lourdes E Santos, Heribert Schunkert, Abdullah Shehab, M Naceur Slimane, Mario Stoll, Ta-Chen Su, Andrey Susekov, Myra Tilney, Brian Tomlinson, Alexandros D Tselepis, Branislav Vohnout, Elisabeth Widén, Shizuya Yamashita, Alberico L Catapano, Kausik K Ray
BACKGROUND: The potential for global collaborations to better inform public health policy regarding major non-communicable diseases has been successfully demonstrated by several large-scale international consortia. However, the true public health impact of familial hypercholesterolaemia (FH), a common genetic disorder associated with premature cardiovascular disease, is yet to be reliably ascertained using similar approaches. The European Atherosclerosis Society FH Studies Collaboration (EAS FHSC) is a new initiative of international stakeholders which will help establish a global FH registry to generate large-scale, robust data on the burden of FH worldwide...
December 2016: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/27932290/the-diagnosis-of-idiopathic-pulmonary-fibrosis-current-and-future-approaches
#18
REVIEW
Fernando J Martinez, Alison Chisholm, Harold R Collard, Kevin R Flaherty, Jeffrey Myers, Ganesh Raghu, Simon L F Walsh, Eric S White, Luca Richeldi
With the recent development of two effective treatments for patients with idiopathic pulmonary fibrosis, an accurate diagnosis is crucial. The traditional approach to diagnosis emphasises the importance of thorough clinical and laboratory evaluations to exclude secondary causes of disease. High-resolution CT is a critical initial diagnostic test and acts as a tool to identify patients who should undergo surgical lung biopsy to secure a definitive histological diagnosis of usual interstitial pneumonia pattern...
January 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27928826/a-feasibility-study-of-awake-videolaryngoscope-assisted-intubation-in-patients-with-periglottic-tumour-using-the-channelled-king-vision-%C3%A2-videolaryngoscope
#19
L Markova, T Stopar-Pintaric, T Luzar, J Benedik, I Hodzovic
Airway management in patients with periglottic tumour is a high-risk procedure with potentially serious consequences. There is no consensus on how best to secure the airway in this group of patients. We conducted a feasibility study of awake tracheal intubation using a King Vision(®) videolaryngoscope with a channelled blade in a cohort of 25 patients, with a periglottic tumour requiring diagnostic or radical surgery. We used 10% and 4% lidocaine to topicalise the airway and midazolam and remifentanil for sedation...
December 7, 2016: Anaesthesia
https://www.readbyqxmd.com/read/27893639/surgical-rescue-the-next-pillar-of-acute-care-surgery
#20
Matthew E Kutcher, Jason L Sperry, Matthew R Rosengart, Deepika Mohan, Marcus K Hoffman, Matthew D Neal, Louis H Alarcon, Gregory A Watson, Juan Carlos Puyana, Graciela M Bauzá, Vaishali D Schuchert, Anisleidy Fombona, Tianhua Zhou, Samuel Zolin, Robert D Becher, Timothy R Billiar, Raquel M Forsythe, Brian S Zuckerbraun, Andrew B Peitzman
BACKGROUND: The evolving field of Acute Care Surgery (ACS) traditionally includes trauma, emergency general surgery, and critical care. However, the critical role of ACS in the rescue of patients with a surgical complication has not been explored. We here describe the role of 'surgical rescue' in the practice of Acute Care Surgery (ACS). METHODS: A prospective, electronic medical record-based ACS registry spanning January 2013 to May 2014 at a large urban academic medical center was screened by ICD-9 codes for acute surgical complications of an operative or interventional procedure...
November 23, 2016: Journal of Trauma and Acute Care Surgery
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