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Natriuretic peptides

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https://www.readbyqxmd.com/read/29164560/the-expression-of-transforming-growth-factor-%C3%AE-1-in-myocardial-tissue-and-concentration-of-serum-b-type-natriuretic-peptide-in-myocardial-remodeling-of-sprague-dawley-rats-treated-with-carvedilol
#1
R Yi, G Xiangyu, S Min
OBJECTIVE: The objective of this study was to observe the expression of transforming growth factor-β1 (TGF-β1) in myocardial tissue and the concentration of serum B-type natriuretic peptide (BNP) in myocardial remodeling of Sprague-Dawley rats induced by isoproterenol (ISO) and the effects of carvedilol intervention. MATERIALS AND METHODS: Thirty rats were divided randomly into three groups: (1) Control group: rats were injected with 5 mL/(kg·d) of saline for 10 days, followed by 10 mL/(kg·d) of saline by gavage for 4 weeks...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29163948/the-heart-matters-in-diabetes-10-year-outcomes-of-peripheral-artery-disease
#2
Thomas Mueller, Franz Hinterreiter, Werner Poelz, Meinhard Haltmayer, Benjamin Dieplinger
Objectives: Mortality rates at 10 years are higher in diabetic patients with chronic lower extremity peripheral arterial disease than in non-diabetic peripheral arterial disease patients. We tested the hypothesis that the predictors of mortality differ between diabetic and non-diabetic peripheral arterial disease patients. Methods: We studied 331 consecutive patients who were <75 years of age, symptomatic for peripheral arterial disease, and admitted to a tertiary care hospital...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/29162289/apelin-apj-system-is-responsible-for-stress-induced-increase-in-atrial-natriuretic-peptide-expression-in-rat-heart
#3
Vecihe Nimet Izgut-Uysal, Nuray Acar, Ilknur Birsen, Filiz Ozcan, Ozlem Ozbey, Hakan Soylu, Sema Avci, Filiz Tepekoy, Gokhan Akkoyunlu, Gultekin Yucel, Ismail Ustunel
BACKGROUND: The cardiovascular system is a primary target of stress and stress is the most important etiologic factor in cardiovascular diseases. Stressors increase expressions of atrial natriuretic peptide (ANP) and apelin in cardiac tissue. AIM: The aim of the present study was to investigate whether stress-induced apelin has an effect on the expression of ANP in the right atrium of rat heart. METHODS: The rats were divided into the control, stress and F13A+stress groups...
October 31, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/29162152/the-peptidylglycine-%C3%AE-amidating-monooxygenase-pam-gene-rs13175330-a-g-polymorphism-is-associated-with-hypertension-in-a-korean-population
#4
Hye Jin Yoo, Minjoo Kim, Minkyung Kim, Jey Sook Chae, Sang-Hyun Lee, Jong Ho Lee
BACKGROUND: Peptidylglycine-α-amidating monooxygenase (PAM) may play a role in the secretion of atrial natriuretic peptide (ANP), which is a hormone involved in the maintenance of blood pressure (BP). The objective of the present study was to determine whether PAM is a novel candidate gene for hypertension (HTN). RESULTS: A total of 2153 Korean participants with normotension and HTN were included. Genotype data were obtained using the Korean Chip. The rs13175330 polymorphism of the PAM gene was selected from the ten single nucleotide polymorphisms (SNPs) most strongly associated with BP...
November 21, 2017: Human Genomics
https://www.readbyqxmd.com/read/29160572/rapid-on-site-evaluation-of-routine-biochemical-parameters-to-predict-right-ventricular-dysfunction-in-and-the-prognosis-of-patients-with-acute-pulmonary-embolism-upon-admission-to-the-emergency-room
#5
Dong Jia, Fan Liu, Qin Zhang, Guang-Qiao Zeng, Xue-Lian Li, Gang Hou
INTRODUCTION: Patients with acute pulmonary embolism(APE)who present with right ventricular dysfunction (RVD) have a worse prognosis. This study aimed to evaluate the value of routine biochemical parameters in predicting RVD and 30-day mortality in patients with APE. METHODS: We retrospectively collected the clinical data for 154 enrolled patients, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), D-dimer, cardiac troponin I (cTnI), and N-terminal pro-brain natriuretic peptide (NT-proBNP)...
November 21, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29159668/new-pulmonary-hypertension-model-in-conscious-dogs-to-investigate-pulmonary-selectivity-of-acute-pharmacological-interventions
#6
Thomas Mondritzki, Philip Boehme, Lena Schramm, Julia Vogel, Ilka Mathar, Peter Ellinghaus, Peter Kolkhof, Erwin Bischoff, Jörg Hüser, Wilfried Dinh, Peter Sandner, Hubert Truebel
PURPOSE: Testing of investigational drugs in animal models is a critical step in drug development. Current models of pulmonary hypertension (PH) have limitations. The most relevant outcome parameters such as pulmonary artery pressure (PAP) are measured invasively which requires anesthesia of the animal. We developed a new canine PH model in which pulmonary vasodilators can be characterized in conscious dogs and lung selectivity can be assessed non-invasively. METHODS: Telemetry devices were implanted to measure relevant hemodynamic parameters in conscious dogs...
November 20, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29158437/cardiac-magnetic-resonance-imaging-in-myocarditis-reveals-persistent-disease-activity-despite-normalization-of-cardiac-enzymes-and-inflammatory-parameters-at-3-month-follow-up
#7
Jan Berg, Jan Kottwitz, Nora Baltensperger, Christine K Kissel, Marina Lovrinovic, Tarun Mehra, Frank Scherff, Christian Schmied, Christian Templin, Thomas F Lüscher, Bettina Heidecker, Robert Manka
BACKGROUND: There is a major unmet need to identify high-risk patients in myocarditis. Although decreasing cardiac and inflammatory markers are commonly interpreted as resolving myocarditis, this assumption has not been confirmed as of today. We sought to evaluate whether routine laboratory parameters at diagnosis predict dynamic of late gadolinium enhancement (LGE) as persistent LGE has been shown to be a risk marker in myocarditis. METHODS AND RESULTS: Myocarditis was diagnosed based on clinical presentation, high-sensitivity troponin T, and cardiac magnetic resonance imaging, after exclusion of obstructive coronary artery disease by angiography...
November 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29158167/clc-3-chloride-channel-is-involved-in-isoprenaline-induced-cardiac-hypertrophy
#8
Chunmei Li, Dan Huang, Jing Tang, Mengqing Chen, Qun Lu, He Li, Mengzhen Zhang, Bin Xu, Jianwen Mao
Isoprenaline, an activator of β-adrenergic receptor, has been found to induce cardiac hypertrophy in vivo and in vitro, but the exact mechanism is still unclear. ClC-3 is a member of the chloride channel family and is highly expressed in mammalian myocardium. In the present study, the role of ClC-3 in isopronaline-induced cardiac hypertrophy was investigated. We found that ClC-3 expression was reduced in isoprenaline-induced hypertrophic H9c2 cells, primary rat neonatal cardiomyocytes and myocardium of C57/BL/6 mice, and this reduction was prevented by the pretreatment of propranolol...
November 17, 2017: Gene
https://www.readbyqxmd.com/read/29158023/statin-has-more-protective-effects-in-ami-patients-with-higher-plasma-bnp-or-nt-probnp-level-but-not-with-lower-left-ventricular-ejection-fraction
#9
Jaelim Cho, Ie Byung Park, Kiyoung Lee, Tae Hoon Ahn, Won Bin Park, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong, Dae Ho Lee
BACKGROUND: The benefit of statin therapy in patients with higher grades of heart failure has yet to be determined. The present study investigated whether statin therapy affects major composite outcomes (MCOs) and all-cause mortality in patients with acute myocardial infarction (AMI) within 1 year after AMI, according to their plasma natriuretic peptide (NP) levels and left ventricular ejection fraction (LVEF). METHODS: A total of 11,492 patients with AMI from two nationwide registry databases in Korea were analyzed...
November 17, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29157885/development-and-validation-of-a-scoring-system-for-the-identification-of-pleural-exudates-of-cardiac-origin
#10
José M Porcel, Lucia Ferreiro, Carme Civit, Luis Valdés, Aureli Esquerda, Richard W Light, Silvia Bielsa
BACKGROUND: Light's criteria misclassify about 30% of cardiac effusions as exudates, possibly leading to unnecessary testing. Our purpose was to derive and validate a scoring model to effectively identify these falsely categorized cardiac effusions, in the setting of natriuretic peptide lacking data. METHODS: We retrospectively analyzed data from 3182 patients with exudative pleural effusions based on Light's criteria, of whom 276 had heart failure (derivation set)...
November 17, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29157592/the-effects-of-continuous-positive-airway-pressure-therapy-on-troponin-t-and-n-terminal-pro-b-type-natriuretic-peptide-in-patients-with-obstructive-sleep-apnoea-a-randomised-controlled-trial
#11
Ya-Shu Chang, Brendon J Yee, Camilla M Hoyos, Keith K Wong, David R Sullivan, Ronald R Grunstein, Craig L Phillips
INTRODUCTION: Untreated obstructive sleep apnoea (OSA) is associated with increased risk of coronary artery disease (CAD) and heart failure. High-sensitivity cardiac troponin (hs Trop-T) and B-type natriuretic peptide (NT-pro-BNP) are sensitive biomarkers for myocardial injury and heart failure respectively. No randomised controlled trials have examined the treatment effect of continuous positive airway pressure (CPAP) in patients with OSA on these biomarkers. METHOD: Patients >21 years old with apnoea-hypopnoea index (AHI) ≥25/h by overnight polysomnography were recruited...
November 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29156586/in-depth-glyco-peptidomics-approach-reveals-unexpected-diversity-of-glycosylated-peptides-and-atypical-post-translational-modifications-in-dendroaspis-angusticeps-snake-venom
#12
Michel Degueldre, Julien Echterbille, Nicolas Smargiasso, Christian Damblon, Charlotte Gouin, Gilles Mourier, Nicolas Gilles, Edwin De Pauw, Loïc Quinton
Animal venoms represent a valuable source of bioactive peptides that can be derived into useful pharmacological tools, or even innovative drugs. In this way, the venom of Dendroaspis angusticeps (DA), the Eastern Green Mamba, has been intensively studied during recent years. It mainly contains hundreds of large toxins from 6 to 9 kDa, each displaying several disulfide bridges. These toxins are the main target of venom-based studies due to their valuable activities obtained by selectively targeting membrane receptors, such as ion channels or G-protein coupled receptors...
November 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29155861/pancreatic-exocrine-insufficiency-in-patients-with-chronic-heart-failure-and-its-possible-association-with-appetite-loss
#13
Tingting Xia, Xichen Chai, Jiaqing Shen
BACKGROUND: Appetite loss is one complication of chronic heart failure (CHF), and its association with pancreatic exocrine insufficiency (PEI) is not well investigated in CHF. AIM: We attempted to detect the association between PEI and CHF-induced appetite. METHODS: Patients with CHF were enrolled, and body mass index (BMI), left ventricular ejection fraction (LVEF), New York Heart Association (NYHA) cardiac function grading, B-type natriuretic peptide (BNP), serum albumin, pro-albumin and hemoglobin were evaluated...
2017: PloS One
https://www.readbyqxmd.com/read/29154956/biomarkers-in-mitral-regurgitation
#14
REVIEW
Magnus Bäck, Rodolfo Pizarro, Marie-Annick Clavel
Mitral regurgitation (MR) is a common cause of heart failure but may also remain silent without either symptoms or altered cardiac function. In the latter case, management is still controversial and biomarkers could be an important means to solving remaining issues in MR management. As objective markers of myocardial stress and early left ventricular dysfunction, biomarkers may for example facilitate the identification of patients with benefit from early surgery of degenerative MR. The most studied biomarkers are the natriuretic peptides (NPs), especially brain NP, as well as its N terminal prohormone...
November 15, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29154432/proposal-for-heart-failure-progression-based-on-the-chloride-theory-worsening-heart-failure-with-increased-vs-non-increased-serum-chloride-concentration
#15
Hajime Kataoka
AIMS: Chloride (Cl) is an established key electrolyte for the activation of the renin-angiotensin-aldosterone system. Recent studies have shown the serum Cl as a key electrolyte for the regulation of body fluid distribution in heart failure (HF) patients. The clinical differences of worsening HF status according to the changes in serum Cl concentration are unclear. METHODS AND RESULTS: Data from 47 chronic HF patients were analysed. Upon worsening HF, each patient exhibited at least two HF-related signs...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29154427/design-of-a-multicentre-randomized-controlled-trial-to-assess-the-safety-and-efficacy-of-dose-titration-by-specialized-nurses-in-patients-with-heart-failure-etific-study-protocol
#16
Juana Oyanguren, LLuisa García-Garrido, Magdalena Nebot Margalef, Iñaki Lekuona, Josep Comin-Colet, Nicolás Manito, Julia Roure, Pilar Ruiz Rodriguez, Cristina Enjuanes, Pedro Latorre, Jesús Torcal Laguna, Susana García-Gutiérrez
AIMS: Heart failure (HF) is associated with many hospital admissions and relatively high mortality, rates decreasing with administration of beta-blockers (BBs), angiotensin-converting-enzyme inhibitors, angiotensin II receptor blockers, and mineralocorticoid receptor antagonists. The effect is dose dependent, suboptimal doses being common in clinical practice. The 2012 European guidelines recommend close monitoring and dose titration by HF nurses. Our main aim is to compare BB doses achieved by patients after 4 months in intervention (HF nurse-managed) and control (cardiologist-managed) groups...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29154425/influence-of-renal-impairment-on-aldosterone-status-calcium-metabolism-and-vasopressin-activity-in-outpatients-with-systolic-heart-failure
#17
Helle Bosselmann, Niels Tonder, György Sölétormos, Freja Gaborit, Kasper Rossing, Kasper Iversen, Jens Peter Goetze, Finn Gustafsson, Morten Schou
AIMS: Renal dysfunction (RD) is associated with increased morbidity and mortality in heart failure (HF). At present, no specific treatment for patients with RD, to prevent progression of HF, has been developed. How different hormone axes-and thereby potential treatment options-are affected by RD in HF warrants further investigations. METHODS AND RESULTS: Patients with left ventricular ejection fraction (LVEF) <0.45% were enrolled prospectively from an outpatient HF clinic...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29154422/beta-blocker-dose-and-markers-of-sympathetic-activation-in-heart-failure-patients-interrelationships-and-prognostic-significance
#18
Alain Cohen-Solal, Arnold F Jacobson, Ileana L Piña
AIMS: Extent of cardiac sympathetic activation can be estimated from physiological parameters, blood biomarkers, and imaging findings. This study examined the prognostic value of three markers of sympathetic activity and their relationship to beta blocker dose in heart failure patients. METHODS AND RESULTS: A post hoc analysis of 858 heart failure subjects in the ADMIRE-HF trial was performed. Variables related to sympathetic activity were plasma norepinephrine, baseline heart rate, the heart to mediastinum (H/M) ratio of (123) I-mIBG uptake, and beta blocker dose...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29153628/discovery-and-in-vivo-effects-of-novel-human-natriuretic-peptide-receptor-a-npr-a-agonists-with-improved-activity-for-rat-npr-a
#19
Takehiko Iwaki, Taisaku Tanaka, Kazuo Miyazaki, Yamato Suzuki, Yoshihiko Okamura, Akira Yamaki, Makoto Iwanami, Naomi Morozumi, Mayumi Furuya, Yoshiaki Oyama
Natriuretic peptide receptor A (NPR-A) agonists were evaluated in vivo by optimizing the structure of quinazoline derivatives to improve agonistic activity for rat NPR-A. A 1,4-Cis-aminocyclohexylurea moiety at 4-position and hydroxy group of d-alaninol at 2-position on the quinazoline ring were found to be important factors in improving rat NPR-A activity. We identified potent quinazoline and pyrido[2,3-d]pyrimidine derivatives against rat NPR-A, with double-digit nanomolar EC50 values. The in vivo results showed that compound 56b administered at 1...
November 6, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29153571/association-of-abnormal-left-ventricular-functional-reserve-with-outcome-in-heart-failure-with-preserved-ejection-fraction
#20
Wojciech Kosmala, Monika Przewlocka-Kosmala, Aleksandra Rojek, Andrzej Mysiak, Andrzej Dabrowski, Thomas H Marwick
OBJECTIVES: This study sought to determine the prognostic value of abnormal diastolic and systolic responses to exercise (on the basis of exertional E/e' and global longitudinal strain rate [GSR]) in a well-characterized population of patients with heart failure with preserved ejection fraction (HFpEF). BACKGROUND: Impaired cardiovascular functional reserve is believed to contribute to adverse outcomes in HFpEF. However, the exact characteristics of pathophysiological profiles associated with increased clinical risk are still poorly defined...
November 10, 2017: JACC. Cardiovascular Imaging
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