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Neil W Johnston, Marita Olsson, Staffan Edsbäcker, Maria Gerhardsson de Verdier, Per Gustafson, Christopher McCrae, Peter V Coyle, R Andrew McIvor
RATIONALE: Common colds are associated with acute respiratory symptom exacerbations in COPD patients. OBJECTIVE: To determine exacerbation risk and severity in COPD patients with/without coincident self-reported colds. METHODS: Global initiative for chronic Obstructive Lung Disease stage I-IV COPD patients electronically transmitted respiratory symptom diaries to research staff daily between December 2006 and April 2009. Respiratory symptom worsening prompted contact by a study nurse and patient assessment to determine if a cold was present or an exacerbation underway...
2017: International Journal of Chronic Obstructive Pulmonary Disease
Stanley I Ejiofor, Jan Stolk, Pablo Fernandez, Robert A Stockley
INTRODUCTION: Patients with chronic obstructive pulmonary disease often experience exacerbations. These events are important as they are a major cause of morbidity and mortality. Recently, it has been increasingly recognized that patients may experience symptoms suggestive of an exacerbation but do not seek treatment, which are referred to as unreported or untreated exacerbations. Symptom diaries used in clinical trials have the benefit of identifying both treated and untreated exacerbation events...
2017: International Journal of Chronic Obstructive Pulmonary Disease
Miguel Gallego, Xavier Pomares, Silvia Capilla, Maria Angeles Marcos, David Suárez, Eduard Monsó, Concepción Montón
BACKGROUND: C-reactive protein (CRP) measurement has proven valuable for detecting exacerbations, but its usefulness in predicting etiology remains controversial. Likewise, its potential value as a marker of severity, which is well established in patients with pneumonia, remains unproven in chronic obstructive pulmonary disease (COPD) exacerbations. METHODS: A cohort study of 118 patients with severe COPD and acute infectious exacerbations were included and followed up over 1 year...
2016: International Journal of Chronic Obstructive Pulmonary Disease
A G Chuchalin, I Ya Tseimakh, A R Momot, A N Mamaev, I A Karbyshev, L A Strozenko
We studied activation of hemostatic reactions together with mechanisms of systemic inflammation and genetic factors responsible for thrombogenic risk in 65 patients suffering exacerbation of chronic obstructive pulmonary disease with 2 or 3 positive criteria proposed by N.Anthonisen at al. (1987). The levels of indicators of systemic inflammation, such as C-reactive protein and tumour necrosis factor-alpha, increased concurrently with those of homocysteine, endothelin-1, Willebrand factor plasminogen activator inhibitor type 1, and thrombin-antithrombin complex (marker of thrombinemia)...
2015: Klinicheskaia Meditsina
Yu Wang, Karey Shumansky, Don D Sin, S F Paul Man, Loubna Akhabir, John E Connett, Nicholas R Anthonisen, Peter D Paré, Andrew J Sandford, Jian-Qing He
OBJECTIVE: We reported association of haplotypes formed by IL-1b (IL1B)-511C/T (rs16944) and a variable number of tandem repeats (rs2234663) in intron 3 of IL-1 receptor antagonist (IL1RN) with rate of lung function decline in smoking-induced COPD. The aim of current study was to further investigate this association. METHODS: We genotyped an additional 19 polymorphisms in IL1 cluster (including IL1A, IL1B and IL1RN) in non-Hispanic whites who had the fastest (n = 268) and the slowest (n = 292) decline of FEV1% predicted in the same study...
2015: International Journal of Clinical and Experimental Pathology
Anthony D Junck, Eva M Escobedo, Bethany M Lipa, Michael Cronan, Colleen Anthonisen, Eduard Poltavskiy, Heejung Bang, Jay J Han
Objectives-The aim of this study was to determine the intra- and inter-rater reliability of sonographic measurements of the median nerve cross-sectional area in individuals with carpal tunnel syndrome and healthy control participants.Methods-The median nerve cross-sectional area was evaluated by sonography in 18 participants with carpal tunnel syndrome (18 upper extremities) and 9 control participants (18 upper extremities) at 2 visits 1 week apart. Two examiners, both blinded to the presence or absence of carpal tunnel syndrome, captured independent sonograms of the median nerve at the levels of the carpal tunnel inlet, pronator quadratus, and mid-forearm...
November 2015: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Jay J Han, Evan de Bie, Alina Nicorici, Richard T Abresch, Colleen Anthonisen, Ruzena Bajcsy, Gregorij Kurillo, Craig M Mcdonald
INTRODUCTION: The Kinect-based reachable workspace relative surface area (RSA) is compared with the performance of upper limb (PUL) assessment in Duchenne muscular dystrophy (DMD). METHODS: 29 individuals with DMD (ages: 7-23; Brooke: 1-5) underwent both Kinect-based reachable workspace RSA and PUL assessments. RSAs were also collected from 24 age-matched controls. Total and quadrant RSAs were compared with the PUL total, shoulder-, middle-, and distal-dimension scores...
April 2016: Muscle & Nerve
Robert Wilson, Antonio Anzueto, Marc Miravitlles, Pierre Arvis, Daniel Haverstock, Mila Trajanovic, Sanjay Sethi
BACKGROUND: Acute exacerbations represent a significant burden for patients with moderate-to-severe chronic obstructive pulmonary disease. Each exacerbation episode is frequently associated with a lengthy recovery and impaired quality of life. Prognostic factors for outpatients that may predict poor outcome after treatment with antibiotics recommended in the guidelines, are not fully understood. We aimed to identify pretherapy factors predictive of clinical failure in elderly (≥60 years old) outpatients with acute Anthonisen type 1 exacerbations...
2015: International Journal of Chronic Obstructive Pulmonary Disease
David F Strykowski, Anni B S Nielsen, Carl Llor, Volkert Siersma, Lars Bjerrum
BACKGROUND: In acute exacerbation of chronic obstructive pulmonary disease (AECOPD) antibiotic overprescribing leads to antimicrobial resistance and underprescribing may cause poor patient outcomes. OBJECTIVE: This study aimed to evaluate changes in over- and underprescribing of antibiotics after two interventions to optimize antibiotic prescribing in AECOPD in Spain. METHODS: In 2008 and 2009, general practitioners (GPs) registered patients in a 3-week period before and after interventions...
August 2015: Family Practice
D Skaare, I L Anthonisen, G Kahlmeter, E Matuschek, O B Natås, M Steinbakk, A Sundsfjord, B E Kristiansen
Resistance to cephalosporins in Haemophilus influenzae is usually caused by characteristic alterations in penicillin-binding protein 3 (PBP3), encoded by the ftsI gene. Resistance to extended-spectrum cephalosporins is associated with high-level PBP3-mediated resistance (high-rPBP3), defined by the second stage S385T substitution in addition to a first stage substitution (R517H or N526K). The third stage L389F substitution is present in some high-rPBP3 strains. High-rPBP3 H. influenzae are considered rare outside Japan and Korea...
2014: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
Luis Reyes, Marcos Restrepo, Oriol Sibila, Stuart Schembri, Peter Williamson, Philip Short, Ahsan Akram, Aran Singanayagam, James Chalmers
COPD Exacerbation RiskSESSION TYPE: Original Investigation SlidePRESENTED ON: Wednesday, October 29, 2014 at 02:45 PM - 04:15 PMPURPOSE: Prior data suggested that among Anthonisen criteria only an increase in sputum purulence was a predictor of clinical failure among mild to moderate COPD outpatients who did not receive antibiotics. In addition the use of a point-of-care C-reactive protein (CRP) test (cutoff > 40 mg/L) significantly increased the predictive accuracy of failure. However, limited data are available regarding the translation of these findings among hospitalized acutely exacerbated COPD (AECOPD) patients who did not receive antibiotics...
October 1, 2014: Chest
F Maceachern, V Goodman, B P Hickey
In the last decade, numerous papers have discussed what has been called the indiscriminate use of intermittent positive pressure breathing therapy (IPPB) for the treatment of obstructive airways disease (Curtis et al., 1968; Loke and Anthonisen, 1974; Cheney et al., 1976; Baker, 1974; Murray, 1974; Barach and Segal, 1975; Sheldon and Gold, 1976; Dolovich et al., 1977). These papers have all failed to show any advantage of positive pressure breathing therapy, either in the acute or chronic stages of obstructive airways disease...
December 1978: Australian Journal of Physiotherapy
Daisuke Kinose, Emiko Ogawa, Megumi Kudo, Satoshi Marumo, Hirofumi Kiyokawa, Yuma Hoshino, Toyohiro Hirai, Kazuo Chin, Shigeo Muro, Michiaki Mishima
BACKGROUND: Bacteria and viruses are major causes of chronic obstructive pulmonary disease (COPD) exacerbations. Molecular components of these pathogens are recognized by pattern-recognition receptors (PRRs) expressed by various cells in the airway, which leads to initiation of inflammatory processes. Expression levels of PRRs in airway inflammatory cells are expected to affect susceptibility to COPD exacerbation. AIMS: This prospective observational study was conducted to detect any association between exacerbation and PRR expression...
January 2016: Clinical Respiratory Journal
Dagfinn Skaare, Inger Lill Anthonisen, Dominique A Caugant, Andrew Jenkins, Martin Steinbakk, Linda Strand, Arnfinn Sundsfjord, Yngvar Tveten, Bjørn-Erik Kristiansen
BACKGROUND: Beta-lactam resistance in Haemophilus influenzae due to ftsI mutations causing altered penicillin-binding protein 3 (PBP3) is increasing worldwide. Low-level resistant isolates with the N526K substitution (group II low-rPBP3) predominate in most geographical regions, while high-level resistant isolates with the additional S385T substitution (group III high-rPBP3) are common in Japan and South Korea.Knowledge about the molecular epidemiology of rPBP3 strains is limited. We combined multilocus sequence typing (MLST) and ftsI/PBP3 typing to study the emergence and spread of rPBP3 in nontypeable H...
2014: BMC Microbiology
Chun Chang, Hong Zhu, Ning Shen, Yahong Chen, Bei He, Jiangchao Zhao, Wanzhen Yao
Abstract Bacterial infection is a major cause of acute exacerbations of chronic obstructive pulmonary disease (AECOPD), which are associated with significantly increased airway and systemic inflammation. However, the relationship among bacteriology, the resolution of inflammation and clinical outcomes is largely unknown. In this study, we recruited consecutive patients hospitalized for AECOPD with purulent sputum. We measured the airway and systemic inflammation levels, the COPD assessment test (CAT) score and adverse outcomes between patients with and without potentially pathogenic microorganisms (PPM)...
February 2015: COPD
H Lange, O H Johansen, L Vold, L J Robertson, I L Anthonisen, K Nygard
In March 2012, a second outbreak of Cryptosporidium parvum affected children following a stay at a holiday farm in Norway; the first outbreak occurred in 2009. We studied a cohort of 145 schoolchildren who had visited the farm, of which 40 (28%) were cases. Cryptosporidium oocysts were detected in faecal samples from humans, goat kids and lambs. Molecular studies revealed C. parvum subtype IIa A19G1R1 in all samples including human samples from the 2009 outbreak. A dose-response relationship was found between the number of optional sessions with animals and illness, increasing from two sessions [risk ratio (RR) 2·7, 95% confidence interval (CI) 0·6-11·5] to six sessions (RR 8·0, 95% CI 1·7-37·7)...
October 2014: Epidemiology and Infection
Marc Miravitlles, Ana Moragas, Silvia Hernández, Carolina Bayona, Carl Llor
BACKGROUND: Anthonisen criteria are widely used to guide the use of antibiotics in exacerbations of COPD. We evaluated the best predictors of outcomes in exacerbations of mild to moderate COPD not treated with antibiotics. METHODS: We used data from 152 patients of the placebo arm of a randomized trial of amoxicillin/clavulanate for exacerbations of mild to moderate COPD. Clinical response in relation to Anthonisen criteria and point-of-care serum C-reactive protein (CRP) tests (cutoff, 40 mg/L) was assessed with multivariate logistic regression analysis...
November 2013: Chest
(no author information available yet)
AIM: To analyze the systemic manifestations of vascular endothelial damage, the activation of hemostatic and inflammatory responses in patients with an infectious inflammation-dependent exacerbation of chronic obstructive pulmonary disease (COPD). SUBJECTS AND METHODS: The paper provides the data of examinations of 111 patients with the clinical signs of an infectious inflammation-dependent exacerbation of COPD who had 2 or 3 positive criteria elaborated by N. Anthonisen et al...
2013: Terapevticheskiĭ Arkhiv
Hye Yun Park, S F Paul Man, Donald Tashkin, Robert A Wise, John E Connett, Nicholas A Anthonisen, Don D Sin
Myeloperoxidase is a strong oxidant stored in primary granules of neutrophils with potent antibacterial and proatherogenic properties. Myeloperoxidase has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, the relationship of myeloperoxidase to health outcomes in COPD is not well known. We measured serum myeloperoxidase levels from 4,677 subjects with mild to moderate airflow limitation in the Lung Health Study. Using a Cox proportional hazards model, we determined the relationship of serum myeloperoxidase concentration to the risk of all-cause and disease specific causes of mortality...
2013: PloS One
Neil W Johnston, Kim Lambert, Patricia Hussack, Maria Gerhardsson de Verdier, Tim Higenbottam, Jonathan Lewis, Paul Newbold, Martin Jenkins, Geoffrey R Norman, Peter V Coyle, R Andrew McIvor
BACKGROUND: Paper-based diaries and self-report of symptom worsening in COPD may lead to underdetection of exacerbations. Epidemiologically, COPD exacerbations exhibit seasonal patterns peaking at year-end. We examined whether the use of a BlackBerry-based daily symptom diary would detect 95% or more of exacerbations and enable characterization of seasonal differences among them. METHODS: Fifty participants with GOLD (Global Initiative for Chronic Obstructive Lung Disease) stage I to IV COPD began a community-based study in December 2007...
August 2013: Chest
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