keyword
https://read.qxmd.com/read/38534535/bio-inspired-magnetically-responsive-silicone-cilia-fabrication-strategy-and-interaction-with-biological-mucus
#1
JOURNAL ARTICLE
Aline Grein-Iankovski, Karina Andrighetti de Oliveira Braga, Daniel Formariz Legendre, Paulo Francisco Guerreiro Cardoso, Watson Loh
Cilia are biological structures essential to drive the mobility of secretions and maintain the proper function of the respiratory airways. However, this motile self-cleaning process is significantly compromised in the presence of silicone tracheal prosthesis, leading to biofilm growth and impeding effective treatment. To address this challenge and enhance the performance of these devices, we propose the fabrication of magnetic silicone cilia, with the prospect of their integration onto silicone prostheses. The present study presents a fabrication method based on magnetic self-assembly and assesses the interaction behavior of the cilia array with biological mucus...
March 7, 2024: Bioengineering
https://read.qxmd.com/read/38526853/reprogramming-of-arachidonic-acid-metabolism-using-%C3%AE-terpineol-to-alleviate-asthma-insights-from-metabolomics
#2
JOURNAL ARTICLE
Ying Rong, Fanglin Liu, Hui Zhou, Tong Yu, Zhaolong Qin, Qianwen Cao, Luyao Liu, Xiaoge Ma, Lingbo Qu, Peirong Xu, Xinglin Liao, Qiman Jiang, Nan Zhang, Xia Xu
Asthma is a chronic inflammatory disorder in airways with typical pathologic features of airway inflammation and mucus hypersecretion. α-Terpineol is a monocyclic terpene found in many natural plants and foods. It has been reported to possess a wide range of pharmacological activities including anti-inflammatory and expectorant effects. However, the role of α-terpineol in asthma and its potential protective mechanism have not been well elucidated. This study is designed to investigate the pharmacological effect and mechanism of α-terpineol on asthmatic mice using the metabolomics platform...
March 25, 2024: Food & Function
https://read.qxmd.com/read/38514093/gasdermin-b-an-asthma-susceptibility-gene-promotes-mavs-tbk1-signaling-and-airway-inflammation
#3
JOURNAL ARTICLE
Tao Liu, Siqi Liu, Xianliang Rui, Ye Cao, Julian Hecker, Feng Guo, Yihan Zhang, Lu Gong, Yihan Zhou, Yuzhen Yu, Nandini Krishnamoorthyni, Samuel Bates, Sung Chun, Nathan Boyer, Shuang Xu, Jin-Ah Park, Mark A Perrella, Bruce D Levy, Scott T Weiss, Hongmei Mou, Benjamin A Raby, Xiaobo Zhou
RATIONALE: Respiratory virus-induced inflammation is the leading cause of asthma exacerbation, frequently accompanied by induction of IFN-stimulated genes (ISGs). How asthma genetic susceptible genes modulate cellular response upon viral infection through fine-tuning ISGs induction and subsequent airway inflammation in genetically susceptible asthmatics remains largely unknown. OBJECTIVES: To decipher the functions of GSDMB in respiratory virus-induced lung inflammation...
March 21, 2024: European Respiratory Journal
https://read.qxmd.com/read/38507725/wogonoside-ameliorates-airway-inflammation-and-mucus-hypersecretion-via-nf-%C3%AE%C2%BAb-stat6-signaling-in-ovalbumin-induced-murine-acute-asthma
#4
JOURNAL ARTICLE
Xiu Yu, Bicheng Cai, Li Yu, Nan Li, Chujie Wu, Zhiquan Hu, Dong Tang, Rongchang Chen, Chen Qiu
Asthma is recognized as a chronic respiratory illness characterized by airway inflammation and airway hyperresponsiveness. Wogonoside, a flavonoid glycoside, is reported to significantly alleviate the inflammation response and oxidative stress. Herein, this study aimed to investigate the therapeutic effect and underlying mechanism of wogonoside on airway inflammation and mucus hypersecretion in a murine asthma model and in human bronchial epithelial cells (16HBE). BALB/c mice were sensitized and challenged with ovalbumin (OVA)...
March 20, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38497834/a-bio-inspired-two-stage-bionic-drag-reduction-method
#5
JOURNAL ARTICLE
Zhengjie Luo, Xuguang Jia, Shining Zhu, Pengfei Zhao, Kaisheng Zhang, Hao Guo
Reducing the surface resistance of underwater vehicles plays an important role in improving cruising speed and cruising mileage. The epidermis of loaches is not only covered with a layer of scale structure but also secretes mucus tissue with a lubricating effect, which makes loaches swim rapidly in muddy water. Study the morphology and structure of the skin of loach and establish a two-stage biomimetic drag reduction model. Adjust the different structural parameters of the model and select the parameters with the best drag reduction rate for the modeling design...
March 1, 2024: Review of Scientific Instruments
https://read.qxmd.com/read/38485545/eosinophil-mucus-interplay-in-severe-asthma-implications-for-treatment-with-biologicals
#6
REVIEW
Carmen Venegas Garrido, Manali Mukherjee, Sarah Svenningsen, Parameswaran Nair
Airway mucus is a hydrogel with unique biophysical properties due to its primary water composition and a small proportion of large anionic glycoproteins or mucins. The predominant mucins in human mucus, MUC5AC and MUC5B, are secreted by specialized cells within the airway epithelium both in normal conditions and in response to various stimuli. Their relative proportions are correlated with specific inflammatory responses and disease mechanisms. The dysregulation of mucin expression is implicated in numerous respiratory diseases, including asthma, COPD, and cystic fibrosis, where the pathogenic role of mucus has been extensively described yet often overlooked...
March 13, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/38470251/inhibition-of-inosine-metabolism-of-the-gut-microbiota-decreases-testosterone-secretion-in-the-testis
#7
JOURNAL ARTICLE
Lei Tang, Xizhong Yang, Mengting Zhou, Lingxin Feng, Cuijie Ji, Jie Liang, Bei Zhang, Ruowu Shen, Luoyang Wang
Growing evidence indicates that gut microbiota is involved in the regulation of the host's sex hormone levels, such as through interfering with the sex hormone metabolism in the intestine. However, if gut microbiota or its metabolites directly influence the sex hormone biosynthesis in the gonad remains largely unknown. Our previous study showed that colistin, as a narrow-spectrum antibiotic, can significantly downregulate the serum testosterone levels and thus enhance the antitumor efficiency of anti-PD-L1 in male mice; however, the underlying mechanism for the regulation of the host's testosterone levels remains uninvestigated...
March 12, 2024: MSystems
https://read.qxmd.com/read/38445918/somatostatin-alleviates-diversion-colitis-after-fecal-stream-bypass-colostomy-surgeries-in-rats
#8
JOURNAL ARTICLE
Yonghao Chen, Xiaoxi Xie, Yaoyu Guo, Yanni Li, Chong Geng, Xiao Li, Chunhui Wang
BACKGROUND: Diversion colitis (DC) is a prevalent complication of colostomy characterized by intestinal inflammation. This study aimed to investigate the therapeutic potential of somatostatin (SST) in managing DC. METHODS: After establishing a rat DC model, SST was administered via Mini Osmotic Pumps 2001W at a pumping rate of 1.0 μL/h. Various techniques, including hematoxylin and eosin staining, periodic acid-Schiff staining, immunofluorescence staining, and electron microscopy were employed to assess the effects of SST...
March 2024: Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38422654/dictamnus-dasycarpus-turcz-attenuates-airway-inflammation-and-mucus-hypersecretion-by-modulating-the-stat6-stat3-foxa2-pathway
#9
JOURNAL ARTICLE
Myung-A Jung, Joo Young Lee, Yu Jin Kim, Kon-Young Ji, Mi Han Lee, Dong Ho Jung, Yun Hee Kim, Taesoo Kim
BACKGROUND: Effects of Dictamnus dasycarpus Turcz. on allergic asthma and their underlying mechanisms remain unclarified. Thus, we investigated the effects of D. dasycarpus Turcz. water extract (DDW) on mucus hypersecretion in mice with ovalbumin (OVA)-induced asthma and human bronchial epithelial cells. METHODS: BALB/c mice were used to establish an OVA-induced allergic asthma model. Mice were grouped into the OVA sensitization/challenge, 100 and 300 mg/kg DDW treatment, and dexamethasone groups...
February 28, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38419167/potassium-competitive-acid-blocker-associated-gastric-mucosal-lesions
#10
REVIEW
Kimitoshi Kubo, Noriko Kimura, Mototsugu Kato
Since the introduction of vonoprazan, a potassium-competitive acid blocker (P-CAB), it has been demonstrated to reversibly inhibit gastric acid secretion by engaging in potassium-competitive ionic binding to H+/K+-ATPase. In contrast, proton pump inhibitors (PPIs) achieve H+/K+-ATPase inhibition through covalent binding to cysteine residues of the proton pump. Reported cases have indicated an emerging trend of P-CAB-related gastropathies, similar to those associated with PPIs, as well as unique gastropathies specific to P-CAB use, such as the identification of web-like mucus...
February 29, 2024: Clinical Endoscopy
https://read.qxmd.com/read/38417159/protein-coronas-derived-from-mucus-act-as-both-spear-and-shield-to-regulate-transferrin-functionalized-nanoparticle-transcellular-transport-in-enterocytes
#11
JOURNAL ARTICLE
Dan Yang, Yuqi Feng, Ying Yuan, Linxuan Zhang, Yao Zhou, Adam C Midgley, Yanrong Wang, Ning Liu, Guoliang Li, Xiaolin Yao, Dechun Liu
The epithelial mucosa is a key biological barrier faced by gastrointestinal, intraoral, intranasal, ocular, and vaginal drug delivery. Ligand-modified nanoparticles demonstrate excellent ability on this process, but their efficacy is diminished by the formation of protein coronas (PCs) when they interact with biological matrices. PCs are broadly implicated in affecting the fate of NPs in vivo and in vitro, yet few studies have investigated PCs formed during interactions of NPs with the epithelial mucosa, especially mucus...
February 28, 2024: ACS Nano
https://read.qxmd.com/read/38375243/comprehensive-landscape-style-investigation-of-the-molecular-mechanism-of-acupuncture-at-st36-single-acupoint-on-different-systemic-diseases
#12
REVIEW
Xiaojing Fan, Yunlong Liu, Shanshan Li, Yongrui Yang, Yinghui Zhao, Wenxi Li, Jiaxin Hao, Zhifang Xu, Bo Zhang, Wei Liu, Suzhao Zhang
The principle of acupoint stimulation efficacy is based on traditional meridian theory. However, the molecular mechanisms underlying the therapeutic effects of acupoints in treating diseases remain unclear in modern scientific understanding. In this study, we selected the ST36 acupoint for investigation and summarized all relevant literature from the PubMed database over the past 10 years. The results indicate that stimulation of ST36 single acupoints has therapeutic effects mainly in models of respiratory, neurological, digestive, endocrine and immune system diseases...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38352468/-p-aeruginosa-trna-fmet-halves-secreted-in-outer-membrane-vesicles-suppress-lung-inflammation-in-cystic-fibrosis
#13
Zhongyou Li, Roxanna Barnaby, Amanda Nymon, Carolyn Roche, Katja Koeppen, Alix Ashare, Deborah A Hogan, Scott A Gerber, Douglas J Taatjes, Thomas H Hampton, Bruce A Stanton
UNLABELLED: Although tobramycin increases lung function in people with cystic fibrosis (pwCF), the density of Pseudomonas aeruginosa (P. aeruginosa) in the lungs is only modestly reduced by tobramycin; hence, the mechanism whereby tobramycin improves lung function is not completely understood. Here, we demonstrate that tobramycin increases 5' tRNA-fMet halves in outer membrane vesicles (OMVs) secreted by laboratory and CF clinical isolates of P. aeruginosa . The 5' tRNA-fMet halves are transferred from OMVs into primary CF human bronchial epithelial cells (CF-HBEC), decreasing OMV-induced IL-8 and IP-10 secretion...
February 3, 2024: bioRxiv
https://read.qxmd.com/read/38347400/extraction-and-fractionation-of-human-gastric-mucins-from-gastric-juice
#14
JOURNAL ARTICLE
Rei Kawashima, Daigo Tsubokawa, Katsunori Iijima, Takafumi Ichikawa
Mucin, a major component of the mucus, is considered to be one of the principal factors in the physiological defense mechanism of the gastrointestinal mucosa. Measuring the mucin content of human gastric mucus is a useful tool for the assessment of Helicobacter pylori (H. pylori) eradication or the involvement of mucus secretion in various gastroduodenal diseases. Here, we describe a methodology for the isolation of the mucin fraction from human gastric juice and the quantification of mucin.
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38342939/mir-30c-affects-the-pathogenesis-of-ulcerative-colitis-by-regulating-target-gene-vip
#15
JOURNAL ARTICLE
Xiang Dong, Yuling Zhan, Minghui Yang, Suwan Li, Hailun Zheng, Yu Gao
MicroRNAs play a crucial role in regulating the epithelial barrier and immune response, which are implicated in the pathogenesis of ulcerative colitis (UC). This study aimed to investigate the role and molecular mechanism of miR-30c in the pathogenesis of UC using a dextran sulfate sodium salt (DSS)-induced colitis model, which is similar to ulcerative colitis. Wild-type (WT) and miR-30c knockout (KO) mice were assigned to either control or DSS-treated groups to evaluate the influence of aberrant miR-30c expression on UC pathogenesis...
February 12, 2024: Scientific Reports
https://read.qxmd.com/read/38340268/repositioning-baloxavir-marboxil-as-vista-agonist-that-ameliorates-experimental-asthma
#16
JOURNAL ARTICLE
Jian-Wen Di, Yi-Xin Wang, Rui-Xue Ma, Zhi-Jie Luo, Wen-Ting Chen, Wan-Mei Liu, Ding-Yi Yuan, Yu-Ying Zhang, Yin-Hao Wu, Cai-Ping Chen, Jun Liu
V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA), a novel negative checkpoint regulator, plays an essential role in allergic pulmonary inflammation in mice. Treatment with a VISTA agonistic antibody could significantly improve asthma symptoms. Thus, for allergic asthma treatment, VISTA targeting may be a compelling approach. In this study, we examined the functional mechanism of VISTA in allergic pulmonary inflammation and screened the FDA-approved drugs for VISTA agonists. By using mass cytometry (CyTOF), we found that VISTA deficiency primarily increased lung macrophage infiltration in the OVA-induced asthma model, accompanied by an increased proportion of M1 macrophages (CD11b+ F4/80+ CD86+ ) and a decreased proportion of M2 macrophages (CD11b+ F4/80+ CD206+ )...
February 10, 2024: Cell Biology and Toxicology
https://read.qxmd.com/read/38336035/fluorene-induced-stress-in-the-benthic-oligochaete-tubifex-tubifex-a-multi-biomarker-assessment-of-toxicological-pathways-and-mechanisms-under-acute-and-subchronic-exposure
#17
JOURNAL ARTICLE
Pramita Sharma, Azubuike Victor Chukwuka, Soumendranath Chatterjee, Shovonlal Bhowmick, Tapan Kumar Mistri, Nimai Chandra Saha
This study examined the multifaceted impacts of fluorene exposure on Tubifex tubifex, encompassing acute (survival analysis and behavioral responses) and subchronic exposure regimens (antioxidant enzyme response and histopathology), molecular docking studies, and generalized read-across analysis. Survival analysis revealed concentration-dependent increases in toxicity over varying time intervals, with LC50 values decreasing from 30.072 mg/L at 24 h to 12.365 mg/L at 96 h, emphasizing the time-sensitive and concentration-responsive nature of the stressor...
February 7, 2024: Chemosphere
https://read.qxmd.com/read/38301820/polystyrene-microplastic-induced-oxidative-stress-triggers-intestinal-barrier-dysfunction-via-the-nf-%C3%AE%C2%BAb-nlrp3-il-1%C3%AE-mclk-pathway
#18
JOURNAL ARTICLE
Guodong Zeng, Jingyi Li, Yuanli Wang, Jingran Su, Zhongbing Lu, Fang Zhang, Wenjun Ding
Emerging evidence has demonstrated the association between microplastics (MPs) with a diameter of <5 mm and the risk of intestinal diseases. However, the molecular mechanisms contributing to MP-induced intestinal barrier dysfunction have not been fully appreciated. In this study, C57BL/6 J mice were exposed to polystyrene microplastics (PS-MPs, 0.2, 1 or 5 μm) at 1 mg/kg body weight daily by oral gavage for 28 days. We found that PS-MPs exposure induced oxidative stress and inflammatory cell infiltration in mice colon, leading to an increased expression of pro-inflammatory cytokine...
January 30, 2024: Environmental Pollution
https://read.qxmd.com/read/38293123/-ruminococcus-torques-is-a-keystone-degrader-of-intestinal-mucin-glycoprotein-releasing-oligosaccharides-used-by-bacteroides-thetaiotaomicron
#19
Sadie R Schaus, Gabriel Vasconcelos Periera, Ana S Luis, Emily Madlambayan, Nicolas Terrapon, Matthew P Ostrowski, Chunsheng Jin, Gunnar C Hansson, Eric C Martens
UNLABELLED: Symbiotic interactions between humans and our communities of resident gut microbes (microbiota) play many roles in health and disease. Some gut bacteria utilize mucus as a nutrient source and can under certain conditions damage the protective barrier it forms, increasing disease susceptibility. We investigated how Ruminococcus torques- a known mucin-degrader that remains poorly studied despite its implication in inflammatory bowel diseases (IBDs)- degrades mucin glycoproteins or their component O -linked glycans to understand its effects on the availability of mucin-derived nutrients for other bacteria...
January 16, 2024: bioRxiv
https://read.qxmd.com/read/38287366/culture-and-expansion-of-murine-proximal-airway-basal-stem-cells
#20
JOURNAL ARTICLE
Meirong Wu, Xiaojing Zhang, Yanjuan Tu, Wenzhao Cheng, Yiming Zeng
BACKGROUND: The stem cell characteristic makes basal cells desirable for ex vivo modeling of airway diseases. However, to date, approaches allowing them extensively in vitro serial expansion and maintaining bona fide stem cell property are still awaiting to be established. This study aims to develop a feeder-free culture system of mouse airway basal stem cells (ABSCs) that sustain their stem cell potential in vitro, providing an experimental basis for further in-depth research and mechanism exploration...
January 30, 2024: Stem Cell Research & Therapy
keyword
keyword
105708
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.