Anastasiia Artuyants, George Guo, Marcella Flinterman, Martin Middleditch, Bincy Jacob, Kate Lee, Laura Vella, Huaqi Su, Michelle Wilson, Lois Eva, Andrew N Shelling, Cherie Blenkiron
Endometrial cancer, the most common gynaecological cancer worldwide, is closely linked to obesity and metabolic diseases, particularly in younger women. New circulating biomarkers have the potential to improve diagnosis and treatment selections, which could significantly improve outcomes. Our approach focuses on extracellular vesicle (EV) biomarker discovery by directly profiling the proteome of EVs enriched from frozen biobanked endometrial tumours. We analysed nine tissue samples to compare three clinical subgroups-low BMI (Body Mass Index) Endometrioid, high BMI Endometrioid, and Serous (any BMI)-identifying proteins related to histological subtype, BMI, and shared secreted proteins...
April 21, 2024: Proteomics