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https://www.readbyqxmd.com/read/29324745/proof-of-concept-study-of-an-at-home-engaging-digital-intervention-for-pediatric-adhd
#1
Naomi O Davis, Jeffrey Bower, Scott H Kollins
OBJECTIVE: Pharmacological and behavioral therapies have limited impact on the distinct neurocognitive impairments associated with ADHD, and existing cognitive training programs have shown limited efficacy. This proof-of-concept study assessed treatment acceptability and explored outcomes for a novel digital treatment targeting cognitive processes implicated in ADHD. METHOD: Participants included 40 children with ADHD and 40 children without ADHD. Following psychiatric screening, ADHD ratings, and baseline neuropsychological measures, participants completed 28-days of at-home treatment...
2018: PloS One
https://www.readbyqxmd.com/read/29324299/boys-with-conduct-problems-and-callous-unemotional-traits-neural-response-to-reward-and-punishment-and-associations-with-treatment-response
#2
Amy L Byrd, Samuel W Hawes, Jeffrey D Burke, Rolf Loeber, Dustin A Pardini
Abnormalities in reward and punishment processing are implicated in the development of conduct problems (CP), particularly among youth with callous-unemotional (CU) traits. However, no studies have examined whether CP children with high versus low CU traits exhibit differences in the neural response to reward and punishment. A clinic-referred sample of CP boys with high versus low CU traits (ages 8-11; n = 37) and healthy controls (HC; n = 27) completed a fMRI task assessing reward and punishment processing...
December 15, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29244542/differential-long-term-medication-impact-on-executive-function-and-delay-aversion-in-adhd
#3
Belen Rubio Morell, Sergio Hernández Expósito
The objective was to compare long-term effects of methylphenidate (MPH) and atomoxetine (ATX) on executive functions (EF) and delay aversion (DAv) in ADHD. A randomized controlled trial was conducted. A comprehensive neuropsychological battery was administered at three moments (Naive, Post-1, Post-2). ADHD participants who showed deficits in the naive evaluation (n = 26) were randomized to receive either MPH (n = 13; Mage = 11 ± 1, MIQ 96 ± 8) or ATX (n = 13; Mage = 10 ± 1, MIQ 106 ± 16...
December 15, 2017: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/29185375/the-effects-of-family-based-mindfulness-intervention-on-adhd-symptomology-in-young-children-and-their-parents-a-randomized-control-trial
#4
Herman H M Lo, Simpson W L Wong, Janet Y H Wong, Jerf W K Yeung, Eline Snel, Samuel Y S Wong
OBJECTIVE: The aim of the study is to investigate the feasibility of a family-based mindfulness intervention in improving children with inattention and hyperactivity symptoms. METHOD: A total of 100 children aged 5 to 7 years with ADHD symptoms and their parents were randomly assigned to a family-based mindfulness intervention ( n = 50) or a wait-list control group ( n = 50). RESULTS: Families from intervention group had greater improvements in children's ADHD symptoms, with medium effect sizes of -0...
November 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/29174864/a-multi-centre-randomised-double-blind-placebo-controlled-clinical-trial-of-methylphenidate-in-the-initial-treatment-of-acute-mania-memap-study
#5
Ulrich Hegerl, Roland Mergl, Christian Sander, Jens Dietzel, Istvan Bitter, Koen Demyttenaere, Ricardo Gusmão, Ana Gonzalez-Pinto Arrillaga, Iñaki Zorrilla, Adriana García Alocén, Victor Perez Sola, Eduard Vieta, Georg Juckel, Ulrich S Zimmermann, Michael Bauer, Pascal Sienaert, Sónia Quintão, Marc-Andreas Edel, Csilla Bolyos, Jose Luis Ayuso-Mateos, Pilar López-García, Michael Kluge
Based on many clinical and preclinical findings the 'vigilance regulation model of mania' postulates that an unstable regulation of wakefulness is a pathogenetic factor in both mania and Attention Deficit Hyperactivity Disorder (ADHD) and induces hyperactivity and sensation seeking as an autoregulatory attempt to stabilize wakefulness. Accordingly, stimulant medications with their vigilance stabilizing properties could have rapid antimanic effects similar to their beneficial effects in ADHD. The MEMAP study - a multi-center, double-blind, placebo-controlled and randomized clinical trial (RCT) - assessed the antimanic efficacy and safety of a 2...
November 22, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29098467/a-6-month-follow-up-of-an-rct-on-behavioral-and-neurocognitive-effects-of-neurofeedback-in-children-with-adhd
#6
Katleen Geladé, Tieme W P Janssen, Marleen Bink, Jos W R Twisk, Rosa van Mourik, Athanasios Maras, Jaap Oosterlaan
To assess the long-term effects of neurofeedback (NFB) in children with attention deficit hyperactivity disorder (ADHD), we compared behavioral and neurocognitive outcomes at a 6-month naturalistic follow-up of a randomized controlled trial on NFB, methylphenidate (MPH), and physical activity (PA). Ninety-two children with a DSM-IV-TR ADHD diagnosis, aged 7-13, receiving NFB (n = 33), MPH (n = 28), or PA (n = 31), were re-assessed 6-months after the interventions. NFB comprised theta/beta training on the vertex (cortical zero)...
November 2, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29063592/omega-3-supplementation-associated-with-improved-parent-rated-executive-function-in-youth-with-mood-disorders-secondary-analyses-of-the-omega-3-and-therapy-oats-trials
#7
Anthony T Vesco, Andrea S Young, L Eugene Arnold, Mary A Fristad
BACKGROUND: Improvements in executive functioning (EF) may lead to improved quality of life and lessened functional impairment for children with mood disorders. The aim was to assess the impact of omega-3 supplementation (Ω3) and psychoeducational psychotherapy (PEP), each alone and in combination, on EF in youth with mood disorders. We completed secondary analyses of two randomized controlled trials (RCTs) of Ω3 and PEP for children with depression and bipolar disorder. METHODS: Ninety-five youths with depression or bipolar disorder not otherwise specified/cyclothymic disorder were randomized in 12-week RCTs...
October 24, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29052846/improvements-of-adolescent-psychopathology-after-insomnia-treatment-results-from-a-randomized-controlled-trial-over-1%C3%A2-year
#8
Eduard J de Bruin, Susan M Bögels, Frans J Oort, Anne Marie Meijer
BACKGROUND: Adolescent insomnia can be treated effectively with cognitive behavioural therapy for insomnia (CBTI). However, little is known about effects of CBTI on psychopathology in adolescents. This study aimed to investigate whether (a) CBTI improves psychopathology in Internet- (IT) and face-to-face group treatment (GT) compared to waitlist (WL), (b) improvement in psychopathology can be attributed to reduced insomnia, (c) improvement in psychopathology remains stable for up to 1 year...
October 20, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29044556/the-social-play-social-skills-and-parent-child-relationships-of-children-with-adhd-12%C3%A2-months-following-a-rct-of-a-play-based-intervention
#9
Gabrielle Barnes, Sarah Wilkes-Gillan, Anita Bundy, Reinie Cordier
BACKGROUND/AIM: There is an urgent need to investigate the long-term impact of social skill interventions for children with attention deficit hyperactivity disorder (ADHD). Interventions targeting the social skills of children with ADHD have limited short-term effectiveness and rarely investigate the long-term impact. Furthermore, these interventions are most frequently conducted in the clinic setting, without including the child's natural settings and interactants, such as their regular playmates and parents...
October 18, 2017: Australian Occupational Therapy Journal
https://www.readbyqxmd.com/read/28967099/vitamin-mineral-treatment-improves-aggression-and-emotional-regulation-in-children-with-adhd-a-fully-blinded-randomized-placebo-controlled-trial
#10
Julia J Rucklidge, Matthew J F Eggleston, Jeanette M Johnstone, Kathryn Darling, Chris M Frampton
BACKGROUND: Evaluation of broad-spectrum micronutrient (vitamins and minerals) treatment for childhood ADHD has been limited to open-label studies that highlight beneficial effects across many aspects of psychological functioning. METHOD: This is the first fully blinded randomized controlled trial of medication-free children (n = 93) with ADHD (7-12 years) assigned to either micronutrients (n = 47) or placebo (n = 46) in a 1:1 ratio, for 10 weeks. All children received standardized ADHD assessments...
October 2, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28966908/the-link-between-adhd-like-inattention-and-obsessions-and-compulsions-during-treatment-of-youth-with-ocd
#11
Andrew G Guzick, Joseph P H McNamara, Adam M Reid, Amanda M Balkhi, Eric A Storch, Tanya K Murphy, Wayne K Goodman, Regina Bussing, Gary R Geffken
Attention-deficit/hyperactivity disorder (ADHD) has been found to be highly comorbid in children and adolescents with obsessive-compulsive disorder (OCD). Some have proposed, however, that obsessive anxiety may cause inattention and executive dysfunction, leading to inappropriate ADHD diagnoses in those with OCD. If this were the case, these symptoms would be expected to decrease following successful OCD treatment. The present study tested this hypothesis and evaluated whether ADHD symptoms at baseline predicted OCD treatment response...
January 2017: Journal of Obsessive-compulsive and related Disorders
https://www.readbyqxmd.com/read/28956183/effectiveness-of-time-related-interventions-in-children-with-adhd-aged-9-15%C3%A2-years-a-randomized-controlled-study
#12
Birgitta Wennberg, Gunnel Janeslätt, Anette Kjellberg, Per A Gustafsson
Specific problems with time and timing that affect daily routines, homework, school work, and social relations have been recognized in children with ADHD. The primary treatments for children with ADHD do not specifically focus on time-related difficulties. The aim of this randomized controlled study (RCT) was to investigate how multimodal interventions, consisting of training in time-processing ability (TPA) and compensation with time-assistive devices (TAD), affect TPA and daily time management (DTM) in children with ADHD and time difficulties, compared with only educational intervention...
September 27, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28868642/assessing-risk-of-bias-in-randomized-controlled-trials-of-methylphenidate-for-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-adhd
#13
Raíssa Rodrigues-Tartari, Walter Swardfager, Giovanni A Salum, Luís A Rohde, Hugo Cogo-Moreira
To test how reliable the tool recommend by Cochrane Collaboration for assessing risk of bias systematic reviews of randomized clinical trials is in the context of methylphenidate for children and adolescents with attention deficit hyperactivity disorder. Confirmatory factor analysis was used to evaluate a unidimensional model for the 7 indicators, applied to 184 Randomized Clinical Trial (RCTs) within a 2015 Cochrane systematic review titled "Methylphenidate for children and adolescents with attention deficit hyperactivity disorder...
September 4, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28853328/the-feasibility-effectiveness-and-process-of-change-of-mindfulness-based-cognitive-therapy-for-adults-with-adhd-a-mixed-method-pilot-study
#14
Lotte Janssen, Alicia M de Vries, Sevket Hepark, Anne E M Speckens
OBJECTIVE: Mindfulness-Based Cognitive Therapy (MBCT) is a promising psychosocial intervention for adult ADHD. The feasibility and effectiveness of an adapted MBCT program is explored, together with the possible process of change. METHOD: Mixed-method study with 31 ADHD patients participating in an adapted MBCT program. Self-report questionnaires on ADHD symptoms, executive functioning, mindfulness skills, self-compassion, patient functioning, and health status were administered before and after MBCT...
August 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28837827/pharmacotherapy-of-emotional-dysregulation-in-adults-with-adhd-a-systematic-review-and-meta-analysis
#15
REVIEW
Francesca Lenzi, Samuele Cortese, Joseph Harris, Gabriele Masi
Emotional dysregulation (ED) is a dysfunction in modifying an emotional state in an adaptive and goal oriented way, with excitability, ease anger, and mood lability. It is present in up to 70% of adults with ADHD, regardless of other comorbidities, and substantially worsens the psychosocial outcomes of the disorder. Besides fronto-parietal circuits mediating top-down control, brain regions involved in bottom-up processes (e.g., amygdala, orbitofrontal cortex, and ventral striatum) are implicated in ED. We performed a systematic review/meta-analysis of double-blind randomized controlled trials of ADHD medications to assess their effects on ED in adults with ADHD...
August 25, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28809658/impact-of-the-cognitive-functional-cog-fun-intervention-on-executive-functions-and-participation-among-children-with-attention-deficit-hyperactivity-disorder-a-randomized-controlled-trial
#16
Jeri Hahn-Markowitz, Itai Berger, Iris Manor, Adina Maeir
OBJECTIVE: We examined the effect of the Cognitive-Functional (Cog-Fun) occupational therapy intervention on executive functions and participation among children with attention deficit hyperactivity disorder (ADHD). METHOD: We used a randomized, controlled study with a crossover design. One hundred and seven children age 7-10 yr diagnosed with ADHD were allocated to treatment or wait-list control group. The control group received treatment after a 3-mo wait. Outcome measures included the Behavior Rating Inventory of Executive Function (BRIEF) and the Canadian Occupational Performance Measure (COPM)...
September 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/28800444/do-parental-adhd-symptoms-reduce-the-efficacy-of-parent-training-for-preschool-adhd-a-secondary-analysis-of-a-randomized-controlled-trial
#17
Rex Forehand, Justin Parent, Virginia D Peisch, Edmund Sonuga-Barke, Nicholas Long, Nicole Lafko Breslend, Howard B Abikoff
Previous studies have suggested that children with Attention-Deficit/Hyperactivity Disorder (ADHD) may benefit less from behavioral parent training (BPT) if their parents have high levels of ADHD symptoms. We conducted a secondary analysis of data from a randomized controlled trial to test the hypothesis that parental ADHD symptoms reduce the efficacy of two BPT programs in a sample of preschoolers with ADHD. One intervention was specifically designed for children with ADHD (NFPP: New Forest Parenting Programme) and one was designed for children with Oppositional Defiant Disorder (ODD) (HNC: Helping the Noncompliant Child)...
October 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28741625/omega-3-polyunsaturated-fatty-acids-in-youths-with-attention-deficit-hyperactivity-disorder-adhd-a-systematic-review-and-meta-analysis-of-clinical-trials-and-biological-studies
#18
JanePei-Chen Chang, Kuan-Pin Su, Valeria Mondelli, Carmine M Pariante
The role of omega-3 polyunsaturated fatty acids (omega-3 or n-3 PUFAs) in the pathogenesis and treatment of children and adolescents with attention deficit hyperactivity disorder (ADHD) is unclear. A systematic review followed by meta-analysis was conducted on: (1) randomized controlled trials (RCTs) assessing the effects of n-3 PUFAs on clinical symptoms and cognition in children and adolescent with ADHD; and (2) case-control studies assessing the levels of n-3 PUFAs in blood and buccal tissues of children and adolescents with ADHD...
July 25, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28738794/escaschool-study-trial-protocol-of-an-adaptive-treatment-approach-for-school-age-children-with-adhd-including-two-randomised-trials
#19
Manfred Döpfner, Christopher Hautmann, Christina Dose, Tobias Banaschewski, Katja Becker, Daniel Brandeis, Martin Holtmann, Thomas Jans, Carolin Jenkner, Sabina Millenet, Tobias Renner, Marcel Romanos, Elena von Wirth
BACKGROUND: The ESCAschool study addresses the treatment of school-age children with attention-deficit/hyperactivity disorder (ADHD) in a large multicentre trial. It aims to investigate three interrelated topics: (i) Clinical guidelines often recommend a stepped care approach, including different treatment strategies for children with mild to moderate and severe ADHD symptoms, respectively. However, this approach has not yet been empirically validated. (ii) Behavioural interventions and neurofeedback have been shown to be effective, but the superiority of combined treatment approaches such as medication plus behaviour therapy or medication plus neurofeedback compared to medication alone remains questionable...
July 24, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28738266/adhd-symptoms-impact-smoking-outcomes-and-withdrawal-in-response-to-varenicline-treatment-for-smoking-cessation
#20
L Cinnamon Bidwell, Hollis C Karoly, Kent E Hutchison, Angela D Bryan
INTRODUCTION: Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with nicotine dependence and difficulty quitting smoking. Few cessation trials specifically consider the impact of ADHD on treatment outcomes, including those testing established pharmacological therapies, such as varenicline. METHODS: The current study focused on the impact of pretreatment ADHD inattention (IN) and hyperactivity-impulsivity (HI) symptoms on treatment outcome in a randomized controlled trial of varenicline [N=205, average age=34...
October 1, 2017: Drug and Alcohol Dependence
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