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https://www.readbyqxmd.com/read/29776383/escalate-adaptive-treatment-approach-for-adolescents-and-adults-with-adhd-study-protocol-for-a-randomized-controlled-trial
#1
Toivo Zinnow, Tobias Banaschewski, Andreas J Fallgatter, Carolin Jenkner, Florence Philipp-Wiegmann, Alexandra Philipsen, Wolfgang Retz, Esther Sobanski, Johannes Thome, Michael Rösler
BACKGROUND: Over the last decade, a wide range of attention-deficit/hyperactivity disorder (ADHD) treatment approaches for adults, including both pharmacological interventions and psychosocial treatments, have been proposed and observed to be efficient. In practice, individual treatment concepts are based on results of clinical studies as well as international guidelines (NICE Guidelines) that recommend a step-by-step treatment approach. Since the evidence supporting this approach is limited, the aim of the present study is to determine an optimal intervention regarding severity levels of ADHD symptomatology conducting a randomized controlled trial...
May 18, 2018: Trials
https://www.readbyqxmd.com/read/29751051/neurocognitive-effects-of-methylphenidate-in-adults-with-attention-deficit-hyperactivity-disorder-a-meta-analysis
#2
REVIEW
Michelle A Pievsky, Robert E McGrath
PIEVSKY, M. A., and R. E. McGrath. Neurocognitive effects of methylphenidate in adults with attention-deficit/hyperactivity disorder: A meta-analysis…NEUROSCI BIOBEHAV REV 81(1) XXX-XXX, 2017.- This meta-analysis summarized 21 double-blind randomized controlled trials with a mean study duration of 18 days comparing the neurocognitive functioning of adults with attention-deficit/hyperactivity disorder (ADHD) on methylphenidate vs placebo. Effect sizes were weighted using a random-effects model. Scores on neurocognitive measures and tests of driving ability were on average higher on methylphenidate than on placebo, g = ...
May 8, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29744363/peer-inclusion-in-interventions-for-children-with-adhd-a-systematic-review-and-meta-analysis
#3
Reinie Cordier, Brandon Vilaysack, Kenji Doma, Sarah Wilkes-Gillan, Renée Speyer
Objective: To assess the effectiveness of peer inclusion in interventions to improve the social functioning of children with ADHD. Methods: We searched four electronic databases for randomized controlled trials and controlled quasi-experimental studies that investigated peer inclusion interventions alone or combined with pharmacological treatment. Data were collected from the included studies and methodologically assessed. Meta-analyses were conducted using a random-effects model...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29674270/response-inhibition-and-emotional-cognition-improved-by-atomoxetine-in-children-and-adolescents-with-adhd-the-action-randomized-controlled-trial
#4
Kristi R Griffiths, John E Leikauf, Tracey W Tsang, Simon Clarke, Daniel F Hermens, Daryl Efron, Leanne M Williams, Michael R Kohn
Although the non-stimulant medication atomoxetine is effective for attention-deficit hyperactivity disorder (ADHD) in children and adolescents, there are still significant gaps in our knowledge about whether atomoxetine improves anxiety symptoms or cognition in children. Furthermore, while cognition has been proposed as an intermediate phenotype for ADHD dysfunction, the relationships between clinical and cognitive outcomes are not yet understood. We addressed these knowledge gaps in a controlled trial using objective assessments of both general and emotional cognitive functions implicated in ADHD and in anxiety, which commonly co-occurs with ADHD...
March 27, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29644473/attention-and-executive-functions-computer-training-for-attention-deficit-hyperactivity-disorder-adhd-results-from-a-randomized-controlled-trial
#5
Aida Bikic, James F Leckman, Torben Ø Christensen, Niels Bilenberg, Søren Dalsgaard
Multicenter randomized clinical superiority single-blind trial investigated the effect of a computer training program targeting multiple cognitive functions. Seventy children with ADHD, aged 6-13, were randomized to intervention or control group. The intervention group used ACTIVATE™ for 8 weeks and both groups received treatment as usual and were assessed in regard to cognitive functions, symptoms, behavioral and functional outcome measures after 8, 12 and 24 weeks. There was no significant effect on the primary outcome, sustained attention (β = - 0...
April 11, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29623286/shared-care-models-in-the-treatment-of-pediatric-attention-deficit-hyperactivity-disorder-adhd-are-they-effective
#6
REVIEW
Meshal A Sultan, Carlos S Pastrana, Kathleen A Pajer
Objectives: The aim of this review is to evaluate the effectiveness of shared/collaborative care between mental health-care providers and primary care providers (PCPs) on the outcomes of children and adolescents with attention-deficit/hyperactivity disorder (ADHD). This evaluation will be very helpful in the allocation of ADHD resources for models with the strongest evidence. Methods: Using the Preferred Reporting Items for Systematic Review and Meta-analysis statement, we searched for randomized controlled trials, cohort, case-control, and cross-sectional studies on shared/collaborative care models in the treatment of ADHD...
January 2018: Health Services Research and Managerial Epidemiology
https://www.readbyqxmd.com/read/29594368/efficacy-of-individualized-social-competence-training-for-children-with-oppositional-defiant-disorders-conduct-disorders-a-randomized-controlled-trial-with-an-active-control-group
#7
Anja Goertz-Dorten, Christina Benesch, Emel Berk-Pawlitzek, Martin Faber, Christopher Hautmann, Martin Hellmich, Timo Lindenschmidt, Lioba Schuh, Rahel Stadermann, Manfred Doepfner
Patient-focused cognitive-behavioral therapy in children with aggressive behavior, which uses group-based social skills training, has resulted in significant reductions in behavioral problems, with effect sizes in the small-to-medium range. However, effects of individually delivered treatments and effects on aggressive behavior and comorbid conditions rated from different perspectives, child functional impairment, child quality of life, parent-child relationship, and parental psychopathology have rarely been assessed...
March 28, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29494784/cognitive-functional-cog-fun-dyadic-intervention-for-children-with-adhd-and-their-parents-impact-on-parenting-self-efficacy
#8
Jeri Hahn-Markowitz, Itai Berger, Iris Manor, Adina Maeir
AIM: The family context of children with ADHD plays a role in intervention outcomes, especially when parents are involved in treatment. Parental participation in evidence-based treatment for ADHD may play a role in improving their own parenting self-efficacy (PSE) as well as child outcomes. This study examined the impact of Cognitive-Functional (Cog-Fun) intervention in occupational therapy (OT) for school-aged children with ADHD, on PSE. METHODS: In this randomized controlled trial with crossover design, 107 children were allocated to intervention and waitlist control groups...
March 1, 2018: Physical & Occupational Therapy in Pediatrics
https://www.readbyqxmd.com/read/29492784/the-efficacy-of-cognitive-behavioral-therapy-for-older-adults-with-adhd-a-randomized-controlled-trial
#9
Mary V Solanto, Craig B Surman, Jose Ma J Alvir
Older adults with ADHD exhibit significant functional impairment, yet there is little research to guide clinicians in evidence-based care of these adults. This study examined response to treatment in older adults who participated in a previous study of the efficacy of cognitive-behavioral treatment (CBT) in adult ADHD. It was hypothesized that older adults would respond less well to CBT than younger adults, given the cognitive demands of the treatment. As described in the original publication, 88 adults who met DSM-IV criteria for ADHD were randomized to receive either a manualized 12-week CBT group intervention targeting executive dysfunction or a parallel Support group...
February 28, 2018: Attention Deficit and Hyperactivity Disorders
https://www.readbyqxmd.com/read/29489078/sluggish-cognitive-tempo-as-a-possible-predictor-of-methylphenidate-response-in-children-with-adhd-a-randomized-controlled-trial
#10
Tanya E Froehlich, Stephen P Becker, Todd G Nick, William B Brinkman, Mark A Stein, James Peugh, Jeffery N Epstein
OBJECTIVE: To examine whether sluggish cognitive tempo (SCT) symptomatology moderates dose response to methylphenidate and whether the impact of SCT on medication response is distinct from attention-deficit/hyperactivity disorder (ADHD) subtype effects. METHODS: Stimulant-naive children with ADHD predominantly inattentive type (ADHD-I; n = 126) or ADHD combined type (ADHD-C; n = 45) aged 7-11 years were recruited from the community from September 2006 to June 2013 to participate in a prospective, randomized, double-blind, 4-week crossover trial of long-acting methylphenidate...
March 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29482662/bright-light-therapy-versus-physical-exercise-to-prevent-co-morbid-depression-and-obesity-in-adolescents-and-young-adults-with-attention-deficit-hyperactivity-disorder-study-protocol-for-a-randomized-controlled-trial
#11
Jutta S Mayer, Katharina Hees, Juliane Medda, Oliver Grimm, Philip Asherson, Mariano Bellina, Michael Colla, Pol Ibáñez, Elena Koch, Antonio Martinez-Nicolas, Adrià Muntaner-Mas, Anna Rommel, Nanda Rommelse, Saskia de Ruiter, Ulrich W Ebner-Priemer, Meinhard Kieser, Francisco B Ortega, Johannes Thome, Jan K Buitelaar, Jonna Kuntsi, J Antoni Ramos-Quiroga, Andreas Reif, Christine M Freitag
BACKGROUND: The risk for major depression and obesity is increased in adolescents and adults with attention-deficit / hyperactivity disorder (ADHD) and adolescent ADHD predicts adult depression and obesity. Non-pharmacological interventions to treat and prevent these co-morbidities are urgently needed. Bright light therapy (BLT) improves day-night rhythm and is an emerging therapy for major depression. Exercise intervention (EI) reduces obesity and improves depressive symptoms. To date, no randomized controlled trial (RCT) has been performed to establish feasibility and efficacy of these interventions targeting the prevention of co-morbid depression and obesity in ADHD...
February 26, 2018: Trials
https://www.readbyqxmd.com/read/29460165/efficacy-and-safety-of-drugs-for-attention-deficit-hyperactivity-disorder-in-children-and-adolescents-a-network-meta-analysis
#12
Sarah C O S Padilha, Suzane Virtuoso, Fernanda S Tonin, Helena H L Borba, Roberto Pontarolo
The aim of this study is to gather evidence of head-to-head double-blind randomized-controlled trials on the efficacy and safety of available treatments for attention deficit hyperactivity disorder (ADHD) in children and adolescents. A systematic review was conducted by two independent reviewers in ten electronic databases (PROSPERO register CRD42016043239). Methodological quality of included studies was evaluated according to the Jadad scale. Network meta-analyses were performed including double-blinded head-to-head trials comparing active allopathic drugs in patients (0-18 years old) diagnosed with ADHD...
February 19, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29453304/protocol-investigating-the-clinical-utility-of-an-objective-measure-of-attention-impulsivity-and-activity-qbtest-for-optimising-medication-management-in-children-and-young-people-with-adhd-qbtest-utility-for-optimising-treatment-in-adhd-quota-a-feasibility
#13
Charlotte L Hall, Marilyn James, Sue Brown, Jennifer L Martin, Nikki Brown, Kim Selby, Julie Clarke, Hena Vijayan, Boliang Guo, Kapil Sayal, Chris Hollis, Madeleine J Groom
INTRODUCTION: Attention-deficit hyperactivity disorder (ADHD) is characterised by symptoms of inattention, hyperactivity and impulsivity. To improve outcomes, the National Institute for Health and Care Excellence ADHD guidelines recommend regular monitoring of symptoms when children commence medication. However, research suggests that routine monitoring rarely happens, and clinicians often rely on subjective information such as reports from parents and teachers to ascertain improvement...
February 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29407718/neurocognitive-correlates-of-treatment-response-in-children-with-tourette-s-disorder
#14
Susanna W Chang, Joseph F McGuire, John T Walkup, Douglas W Woods, Lawrence Scahill, Sabine Wilhelm, Alan L Peterson, James Dziura, John Piacentini
This paper examined neurocognitive functioning and its relationship to behavior treatment response among youth with Tourette's Disorder (TD) in a large randomized controlled trial. Participants diagnosed with TD completed a brief neurocognitive battery assessing inhibitory functions, working memory, and habit learning pre- and post-treatment with behavior therapy (CBIT, Comprehensive Behavioral Intervention for Tics) or psychoeducation plus supportive therapy (PST). At baseline, youth with tics and Attention Deficit Hyperactivity Disorder (ADHD) exhibited some evidence of impaired working memory and simple motor inhibition relative to youth with tics without ADHD...
March 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29396712/informant-related-effects-of-neurofeedback-and-cognitive-training-in-children-with-adhd-including-a-waiting-control-phase-a-randomized-controlled-trial
#15
Franziska Minder, Agnieszka Zuberer, Daniel Brandeis, Renate Drechsler
There is controversy regarding the clinical efficacy of neurofeedback (NF) and computerized cognitive training (CogT) as treatments for ADHD. Meta-analyses claim that probably blinded teachers observe smaller effects than parents, because they are less biased. We investigated informant-specific effects by manipulating the involvement of informants, by controlling for waiting time effects, and by adding a blinded outcome measure. Seventy-seven children with ADHD were randomly allocated to slow cortical potential NF or to individualized CogT (of attention, working memory or inhibition)...
February 2, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29362929/does-the-efficacy-of-parent-child-training-depend-on-maternal-symptom-improvement-results-from-a-randomized-controlled-trial-on-children-and-mothers-both-affected-by-attention-deficit-hyperactivity-disorder-adhd
#16
Alexander Häge, Barbara Alm, Tobias Banaschewski, Katja Becker, Michael Colla, Christine Freitag, Julia Geissler, Alexander von Gontard, Erika Graf, Barbara Haack-Dees, Susann Hänig, Klaus Hennighausen, Sarah Hohmann, Christian Jacob, Charlotte Jaite, Christine Jennen-Steinmetz, Viola Kappel, Swantje Matthies, Alexandra Philipsen, Luise Poustka, Wolfgang Retz, Michael Rösler, Katja Schneider-Momm, Esther Sobanski, Timo D Vloet, Andreas Warnke, Thomas Jans
Multimodal treatment of children with ADHD often includes parent-child training (PCT). However, due to the high heritability, parents of children with ADHD are frequently also affected by the disorder, which is likely to constitute a significant barrier to successful treatment of the child. This secondary analysis of our randomized controlled multicentre AIMAC trial (ADHD in mothers and children) investigates whether children's outcomes following parent-child training in combination with maternal ADHD treatment depend on maternal symptom improvement...
January 23, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29356899/mindfulness-vs-psychoeducation-in-adult-adhd-a-randomized-controlled-trial
#17
E Hoxhaj, C Sadohara, P Borel, R D'Amelio, E Sobanski, H Müller, B Feige, S Matthies, Alexandra Philipsen
BACKGROUND: Mindfulness training is a promising treatment approach in adult ADHD. However, there has not yet been a randomized controlled trial comparing mindfulness to an active control condition. In this study, we assessed the efficacy of a mindfulness training program (MAP) compared to structured psychoeducation (PE). METHODS: After randomization 81 medication-free adult ADHD patients participated either in an 8-week MAP or PE group program. At baseline (T1), after 8 weeks (T2) and after 8 months (T3), severity of ADHD and associated symptoms (depression, general psychopathology, quality of life) were measured with the Conner's ADHD Rating Scales (CAARS), the Beck Depression Inventory (BDI), the Brief Symptom Inventory (BSI) and the SF-36 by self and blind observer ratings...
January 22, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29324745/proof-of-concept-study-of-an-at-home-engaging-digital-intervention-for-pediatric-adhd
#18
Naomi O Davis, Jeffrey Bower, Scott H Kollins
OBJECTIVE: Pharmacological and behavioral therapies have limited impact on the distinct neurocognitive impairments associated with ADHD, and existing cognitive training programs have shown limited efficacy. This proof-of-concept study assessed treatment acceptability and explored outcomes for a novel digital treatment targeting cognitive processes implicated in ADHD. METHOD: Participants included 40 children with ADHD and 40 children without ADHD. Following psychiatric screening, ADHD ratings, and baseline neuropsychological measures, participants completed 28-days of at-home treatment...
2018: PloS One
https://www.readbyqxmd.com/read/29324299/boys-with-conduct-problems-and-callous-unemotional-traits-neural-response-to-reward-and-punishment-and-associations-with-treatment-response
#19
Amy L Byrd, Samuel W Hawes, Jeffrey D Burke, Rolf Loeber, Dustin A Pardini
Abnormalities in reward and punishment processing are implicated in the development of conduct problems (CP), particularly among youth with callous-unemotional (CU) traits. However, no studies have examined whether CP children with high versus low CU traits exhibit differences in the neural response to reward and punishment. A clinic-referred sample of CP boys with high versus low CU traits (ages 8-11; n = 37) and healthy controls (HC; n = 27) completed a fMRI task assessing reward and punishment processing...
December 15, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29244542/differential-long-term-medication-impact-on-executive-function-and-delay-aversion-in-adhd
#20
Belen Rubio Morell, Sergio Hernández Expósito
The objective was to compare long-term effects of methylphenidate (MPH) and atomoxetine (ATX) on executive functions (EF) and delay aversion (DAv) in ADHD. A randomized controlled trial was conducted. A comprehensive neuropsychological battery was administered at three moments (Naive, Post-1, Post-2). ADHD participants who showed deficits in the naive evaluation (n = 26) were randomized to receive either MPH (n = 13; Mage  = 11 ± 1, MIQ 96 ± 8) or ATX (n = 13; Mage  = 10 ± 1, MIQ 106 ± 16...
December 15, 2017: Applied Neuropsychology. Child
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