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https://www.readbyqxmd.com/read/28821301/space-type-radiation-induces-multimodal-responses-in-the-mouse-gut-microbiome-and-metabolome
#1
David Casero, Kirandeep Gill, Vijayalakshmi Sridharan, Igor Koturbash, Gregory Nelson, Martin Hauer-Jensen, Marjan Boerma, Jonathan Braun, Amrita K Cheema
BACKGROUND: Space travel is associated with continuous low dose rate exposure to high linear energy transfer (LET) radiation. Pathophysiological manifestations after low dose radiation exposure are strongly influenced by non-cytocidal radiation effects, including changes in the microbiome and host gene expression. Although the importance of the gut microbiome in the maintenance of human health is well established, little is known about the role of radiation in altering the microbiome during deep-space travel...
August 18, 2017: Microbiome
https://www.readbyqxmd.com/read/28816483/effect-of-travel-speed-on-the-visual-control-of-steering-toward-a-goal
#2
Rongrong Chen, Diederick C Niehorster, Li Li
Previous studies have proposed that people can use visual cues such as the instantaneous direction (i.e., heading) or future path trajectory of travel specified by optic flow or target visual direction in egocentric space to steer or walk toward a goal. In the current study, we examined what visual cues people use to guide their goal-oriented locomotion and whether their reliance on such visual cues changes as travel speed increases. We presented participants with optic flow displays that simulated their self-motion toward a target at various travel speeds under two viewing conditions in which we made target egocentric direction available or unavailable for steering...
August 17, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28815713/clinical-winnicott-traveling-a-revolutionary-road
#3
Vincenzo Bonaminio
The author contends that, contrary to the usual perception that Winnicott followed a linear progression "through pediatrics to psychoanalysis," Winnicott's vision was always a psychoanalytic one, even during his early pediatric work. His place in the development of psychoanalytic theory is highlighted, and the author discusses such key Winnicottian concepts as transitional space, the false self, and the use of the object. Winnicott's unique approach to the form and value of analytic interpretation is particularly emphasized, and his thoughts on the treatment of depression are also addressed, as well as his distinction between regression and withdrawal...
July 2017: Psychoanalytic Quarterly
https://www.readbyqxmd.com/read/28811532/protein-expression-changes-caused-by-spaceflight-as-measured-for-18-russian-cosmonauts
#4
Irina M Larina, Andrew J Percy, Juncong Yang, Christoph H Borchers, Andrei M Nosovsky, Anatoli I Grigoriev, Evgeny N Nikolaev
The effects of spaceflight on human physiology is an increasingly studied field, yet the molecular mechanisms driving physiological changes remain unknown. With that in mind, this study was performed to obtain a deeper understanding of changes to the human proteome during space travel, by quantitating a panel of 125 proteins in the blood plasma of 18 Russian cosmonauts who had conducted long-duration missions to the International Space Station. The panel of labeled prototypic tryptic peptides from these proteins covered a concentration range of more than 5 orders of magnitude in human plasma...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28795236/a-novel-continuous-inhibitory-control-task-variation-in-individual-performance-by-young-pheasants-phasianus-colchicus
#5
Christina Meier, Sara Raj Pant, Jayden O van Horik, Philippa R Laker, Ellis J G Langley, Mark A Whiteside, Frederick Verbruggen, Joah R Madden
Inhibitory control enables subjects to quickly react to unexpectedly changing external demands. We assessed the ability of young (8 weeks old) pheasants Phasianus colchicus to exert inhibitory control in a novel response-inhibition task that required subjects to adjust their movement in space in pursuit of a reward across changing target locations. The difference in latencies between trials in which the target location did and did not change, the distance travelled towards the initially indicated location after a change occurred, and the change-signal reaction time provided a consistent measure that could be indicative of a pheasant's inhibitory control...
August 9, 2017: Animal Cognition
https://www.readbyqxmd.com/read/28795229/spatial-characteristics-of-jaw-movements-during-chewing-in-children-with-cerebral-palsy-a-pilot-study
#6
Ignatius S B Nip, Erin M Wilson, Lucia Kearney
This study compared jaw motion between children with cerebral palsy (CP) and their typically-developing (TD) peers during chewing. The jaw movements of 11 children with spastic CP (GMFCS levels II-V) all of whom were exclusively oral feeders with no reported clinical issues with feeding [mean age = 7.49 (2.30) years; 7 males, 4 females] and 11 age- and sex-matched TD peers [mean age = 7.54 (2.35) years] were recorded using optical motion capture. Participants chewed five trials of three different consistencies, including puree, mechanical soft, and solid...
August 9, 2017: Dysphagia
https://www.readbyqxmd.com/read/28794579/temporal-and-geographic-patterns-of-kinship-structure-in-common-dolphins-delphinus-delphis-suggest-site-fidelity-and-female-biased-long-distance-dispersal
#7
Laura Ball, Kypher Shreves, Małgorzata Pilot, André E Moura
ABSTRACT: Social structure plays a crucial role in determining a species' dispersal patterns and genetic structure. Cetaceans show a diversity of social and mating systems, but their effects on dispersal and genetic structure are not well known, in part because of technical difficulties in obtaining robust observational data. Here, we combine genetic profiling and GIS analysis to identify patterns of kin distribution over time and space, to infer mating structure and dispersal patterns in short-beaked common dolphins (Delphinus delphis)...
2017: Behavioral Ecology and Sociobiology
https://www.readbyqxmd.com/read/28792909/set-based-discrete-particle-swarm-optimization-based-on-decomposition-for-permutation-based-multiobjective-combinatorial-optimization-problems
#8
Xue Yu, Wei-Neng Chen, Tianlong Gu, Huaxiang Zhang, Huaqiang Yuan, Sam Kwong, Jun Zhang
This paper studies a specific class of multiobjective combinatorial optimization problems (MOCOPs), namely the permutation-based MOCOPs. Many commonly seen MOCOPs, e.g., multiobjective traveling salesman problem (MOTSP), multiobjective project scheduling problem (MOPSP), belong to this problem class and they can be very different. However, as the permutation-based MOCOPs share the inherent similarity that the structure of their search space is usually in the shape of a permutation tree, this paper proposes a generic multiobjective set-based particle swarm optimization methodology based on decomposition, termed MS-PSO/D...
August 7, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28770594/multi-month-prescriptions-fast-track-refills-and-community-art-groups-results-from-a-process-evaluation-in-malawi-on-using-differentiated-models-of-care-to-achieve-national-hiv-treatment-goals
#9
REVIEW
Margaret L Prust, Clement K Banda, Rose Nyirenda, Frank Chimbwandira, Thokozani Kalua, Andreas Jahn, Michael Eliya, Katie Callahan, Peter Ehrenkranz, Marta R Prescott, Elizabeth A McCarthy, Elya Tagar, Andrews Gunda
INTRODUCTION: In order to facilitate scale-up of antiretroviral therapy (ART) in Malawi, innovative and pragmatic models have been developed to optimize the efficiency of HIV service delivery. In particular, three models of differentiated care have emerged for stable patients: adjusted appointment spacing through multi-month scripting (MMS); fast-track drug refills (FTRs) on alternating visits; and community ART groups (CAGs) where group members rotate in collecting medications at the facility for all members...
July 21, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28769893/imported-zika-virus-in-a-european-city-how-to-prevent-local-transmission
#10
Joan-Pau Millet, Tomàs Montalvo, Ruben Bueno-Marí, Arancha Romero-Tamarit, Albert Prats-Uribe, Lidia Fernández, Esteve Camprubí, Lucía Del Baño, Victor Peracho, Jordi Figuerola, Elena Sulleiro, Miguel J Martínez, Joan A Caylà
Background: On February 1st 2016 the WHO declared the Zika Virus (ZIKV) infection a worldwide public health emergency because of its rapid expansion and severe complications, such as Guillain-Barré Syndrome or microcephaly in newborn. The huge amount of people traveling to endemic areas and the presence of Aedes albopictus in Barcelona increase the risk of autochtonous transmission. The objective of this study was to describe the first ZIKV cases diagnosed in our city and to analyze the surveillance, prevention, and control measures implemented to avoid autochthonous transmission...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28767703/simulated-space-radiation-sensitizes-bone-but-not-muscle-to-the-catabolic-effects-of-mechanical-unloading
#11
Andrew R Krause, Toni L Speacht, Yue Zhang, Charles H Lang, Henry J Donahue
Deep space travel exposes astronauts to extended periods of space radiation and mechanical unloading, both of which may induce significant muscle and bone loss. Astronauts are exposed to space radiation from solar particle events (SPE) and background radiation referred to as galactic cosmic radiation (GCR). To explore interactions between skeletal muscle and bone under these conditions, we hypothesized that decreased mechanical load, as in the microgravity of space, would lead to increased susceptibility to space radiation-induced bone and muscle loss...
2017: PloS One
https://www.readbyqxmd.com/read/28764324/large-scale-structural-characterization-of-drug-and-drug-like-compounds-by-high-throughput-ion-mobility-mass-spectrometry
#12
Kelly M Hines, Dylan H Ross, Kimberly L Davidson, Matthew F Bush, Libin Xu
Ion mobility-mass spectrometry (IM-MS) can provide orthogonal information, i.e. m/z and collision cross section (CCS), for the identification of drugs and drug metabolites. However, only a small number of CCS values are available for drugs, which limits the use of CCS as an identification parameter and the assessment of structure-function relationships of drugs using IM-MS. Here we report the development of a rapid workflow for the measurement of CCS values of a large number of drug or drug-like molecules in nitrogen on the widely available traveling wave IM-MS (TWIM-MS) platform...
August 1, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28764119/trans-pacific-transport-of-dust-aerosols-from-east-asia-insights-gained-from-multiple-observations-and-modeling
#13
Jianping Guo, Mengyun Lou, Yucong Miao, Yuan Wang, Zhaoliang Zeng, Huan Liu, Jing He, Hui Xu, Fu Wang, Min Min, Panmao Zhai
East Asia is one of the world's largest sources of dust and anthropogenic pollution. Dust particles originating from East Asia have been recognized to travel across the Pacific to North America and beyond, thereby affecting the radiation incident on the surface as well as clouds aloft in the atmosphere. In this study, integrated analyses are performed focusing on one trans-Pacific dust episode during 12-22 March 2015, based on space-borne, ground-based observations, reanalysis data combined with Hybrid Single Particle Lagrangian Integrated Trajectory Model (HYSPLIT), and the Weather Research and Forecasting Model coupled with Chemistry (WRF-Chem)...
July 27, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28752340/importance-of-the-moskowitz-artery-in-the-laparoscopic-medial-approach-to-splenic-flexure-mobilization-a-cadaveric-study
#14
A Garcia-Granero, L Sánchez-Guillén, O Carreño, J Sancho Muriel, E Alvarez Sarrado, D Fletcher Sanfeliu, B Flor Lorente, M Frasson, F Martinez Soriano, E Garcia-Granero
BACKGROUND: The medial approach in laparoscopic splenic flexure mobilization is based on the entrance to the lesser sac just above the ventral edge of the pancreas (VEOP). The artery of Moskowitz runs through the base of the mesocolon, just above the VEOP. The aim of this study was to assess the incidence of the artery of Moskowitz, its route and its distance from the VEOP. METHODS: We performed a cadaveric study on 27 human cadavers. The vascular arcades of the splenic flexure were dissected, the number of vascular arches, and the origin and localization of its terminal anastomosis were recorded...
July 27, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28752024/local-environment-and-social-factors-in-primary-school-children-s-afterschool-commute-in-china
#15
John Zacharias, Bai Zhen, Xili Han, Yunshi Huang
The rapid decline in young children's active commutes to and from school has prompted investigations into ways to raise activity levels. The period after school is recognized as very important in the daily activity regime of primary school children. In this study, we examine the relative effects of local environmental factors and socio-economic status on children's after-school commute mode choice. Environmental factors are pedestrian priority streets, street intersection density, motorways, shops, and play spaces...
September 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28721811/moving-to-the-rhythm-with-clock-circadian-genes-autophagy-mtor-and-sirt1-in-degenerative-disease-and-cancer
#16
Kenneth Maiese
BACKGROUND: The mammalian circadian clock and its associated clock genes are increasingly be recognized as critical components for a number of physiological and disease processes that extend beyond hormone release, thermal regulation, and sleep-wake cycles. New evidence suggests that clinical behavior disruptions that involve prolonged shift work and even space travel may negatively impact circadian rhythm and lead to multi-system disease. METHODS: In light of the significant role circadian rhythm can hold over the body's normal physiology as well as disease processes, we examined and discussed the impact circadian rhythm and clock genes hold over lifespan, neurodegenerative disorders, and tumorigenesis...
July 17, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28721604/a-space-of-one-s-own-barbosa-du-bocage-the-foundation-of-the-national-museum-of-lisbon-and-the-construction-of-a-career-in-zoology-1851-1907
#17
Daniel Gamito-Marques
This paper discusses the life and scientific work of José Vicente Barbosa du Bocage (1823-1907), a nineteenth-century Portuguese naturalist who carved a new place for zoological research in Portugal and built up a prestigious scientific career by securing appropriate physical and institutional spaces to the discipline. Although he was appointed professor of zoology at the Lisbon Polytechnic School, an institution mainly devoted to the preparatory training of military officers and engineers, he succeeded in creating the conditions that allowed him to develop consistent research in zoology at this institution...
July 18, 2017: Journal of the History of Biology
https://www.readbyqxmd.com/read/28715435/spatial-patterns-of-dengue-cases-in-brazil
#18
Fernando Jose Antonio, Andreia Silva Itami, Sergio de Picoli, Jorge Juarez Vieira Teixeira, Renio Dos Santos Mendes
Dengue infection plays a central role in our society, since it is the most prevalent vector-borne viral disease affecting humans. We statistically investigated patterns concerning the spatial spreading of dengue epidemics in Brazil, as well as their temporal evolution in all Brazilian municipalities for a period of 12 years. We showed that the distributions of cases in municipalities follow power laws persistent in time and that the infection scales linearly with the population of the municipalities. We also found that the average number of dengue cases does not have a clear dependence on the longitudinal position of municipalities...
2017: PloS One
https://www.readbyqxmd.com/read/28699836/blogs-and-the-art-of-dying-blogging-with-and-about-severe-cancer-in-late-modern-swedish-society
#19
Yvonne Andersson
In recent years, the common and mundane dying has begun to take place in the public space of the Internet. Among the blogs about food, fashion, travel, and other joyful aspects of life, blogs about severe disease and dying have appeared. The aim of this article is to describe some characteristic features of a sample of cancer blogs and to discuss them in the light of Zygmunt Bauman's theory of the rationalization of death in modernity and theories about networked media, especially the theories about "affective labor" and "ambient intimacy" by McCosker, Darcy, and Pfister...
January 1, 2017: Omega
https://www.readbyqxmd.com/read/28696377/task-assignment-and-path-planning-for-multiple-autonomous-underwater-vehicles-using-3d-dubins-curves-%C3%A2
#20
Wenyu Cai, Meiyan Zhang, Yahong Rosa Zheng
This paper investigates the task assignment and path planning problem for multiple AUVs in three dimensional (3D) underwater wireless sensor networks where nonholonomic motion constraints of underwater AUVs in 3D space are considered. The multi-target task assignment and path planning problem is modeled by the Multiple Traveling Sales Person (MTSP) problem and the Genetic Algorithm (GA) is used to solve the MTSP problem with Euclidean distance as the cost function and the Tour Hop Balance (THB) or Tour Length Balance (TLB) constraints as the stop criterion...
July 11, 2017: Sensors
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