Konstantinos Mengrelis, Gerhard Niederacher, Lisa Prickler, Verena Kainz, Anna Marianne Weijler, Elisa Rudolph, Victoria Stanek, Julia Eckl-Dorna, Ulrike Baranyi, Andreas Spittler, Margarete Focke-Tejkl, Barbara Bohle, Rudolf Valenta, Christian Friedrich Wilhelm Becker, Thomas Wekerle, Birgit Linhart
Up to a third of the world's population suffers from allergies, yet the effectiveness of available preventative measures remains, at large, poor. Consequently, the development of successful prophylactic strategies for the induction of tolerance against allergens is crucial. In proof-of-concept studies, our laboratory has previously shown that the transfer of autologous hematopoietic stem cells (HSC) or autologous B cells expressing a major grass pollen allergen, Phl p 5, induces robust tolerance in mice. However, eventual clinical translation would require safe allergen expression without the need for retroviral transduction...
March 3, 2024: Cells