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Y Shivani, Y Subhash, L Tushar, Ch Sasikala, Ch V Ramana
Metagenome analysis of forty samples indicated a rich diversity of free living spirochaetes among Indian habitats. Only 2-3% of the total bacterial diversity was represented by spirochaetes with five distinct phylogenetic OTUs. A strain (JC230(T)) was brought to cultivation and its 16S rRNA gene sequence showed highest sequence similarity with that of Spirochaeta asiatica Z-7591(T) (90.78%). Genome sequence analysis of strain JC230(T) indicates the presence of 117 genes related to motility and chemotaxis. Strain JC230(T) is an obligate anaerobe...
March 2015: Systematic and Applied Microbiology
Yinon Shapira, Nancy Agmon-Levin, Carlo Selmi, Jana Petríková, Ori Barzilai, Maya Ram, Nicola Bizzaro, Gabriele Valentini, Marco Matucci-Cerinic, Juan-Manuel Anaya, Bat-sheva Porat Katz, Yehuda Shoenfeld
The identification of etiological factors in the induction of autoimmunity has remained elusive despite an enormous effort at dissection of the molecular structure of the target antigens and effector mechanisms. One characteristic feature of autoantigens is their repetitive structure as well as their conservation and evolution. Toxoplasma (T.) gondii is a primitive protozoan. We hypothesized that patients with autoimmune disease would have broad reactions against Toxoplasma antigens based on autoantigen conservation...
August 2012: Journal of Autoimmunity
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