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Inhaled steroids for chronic lung disease in infants

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https://www.readbyqxmd.com/read/26044104/inhalation-or-instillation-of-steroids-for-the-prevention-of-bronchopulmonary-dysplasia
#1
REVIEW
Dirk Bassler
Survival of extremely preterm infants has increased over recent years, but bronchopulmonary dysplasia (BPD) remains a major cause of morbidity. In the USA, BPD is the most common chronic respiratory disorder of infancy and affects the pulmonary and overall health of 10,000 preterm infants annually. Preclinical and clinical studies suggest a crucial role for lung inflammation and host immune response in the pathogenesis of BPD. Inflammation may result from, amongst others, chorioamnionitis, postnatal infection, ventilation, and the administration of oxygen...
2015: Neonatology
https://www.readbyqxmd.com/read/25719546/does-chronic-oxygen-dependency-in-preterm-infants-with-bronchopulmonary-dysplasia-at-nicu-discharge-predict-respiratory-outcomes-at-3-years-of-age
#2
A Lodha, K Ediger, Y Rabi, S Lodha, S Tang, A Bhandari, R Sauve, V Bhandari
OBJECTIVE: To determine whether chronic oxygen dependency at the time of discharge from the neonatal intensive care unit (NICU) in infants with bronchopulmonary dysplasia (BPD) predicts respiratory outcomes at 3 years. STUDY DESIGN: Preterm infants ⩽1250 g without BPD, BPD and BPD with chronic oxygen dependency were identified from the Southern Alberta Perinatal Follow-up clinic database (1995-2007). Respiratory outcomes at 4, 8, 18 and 36 months corrected age following NICU discharge were examined...
July 2015: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/25505695/the-expanding-role-of-aerosols-in-systemic-drug-delivery-gene-therapy-and-vaccination-an-update
#3
REVIEW
Beth L Laube
Until the late 1990s, aerosol therapy consisted of beta2-adrenergic agonists, anti-cholinergics, steroidal and non-steroidal agents, mucolytics and antibiotics that were used to treat patients with asthma, COPD and cystic fibrosis. Since then, inhalation therapy has matured to include drugs that: (1) are designed to treat diseases outside the lung and whose target is the systemic circulation (systemic drug delivery); (2) deliver nucleic acids that lead to permanent expression of a gene construct, or protein coding sequence, in a population of cells (gene therapy); and (3) provide needle-free immunization against disease (aerosolized vaccination)...
2014: Translational Respiratory Medicine
https://www.readbyqxmd.com/read/25170598/fetal-growth-restriction-is-worse-than-extreme-prematurity-for-the-developing-lung
#4
COMPARATIVE STUDY
Sophie Soudée, Lucie Vuillemin, Corinne Alberti, Damir Mohamed, Odile Becquet, Caroline Farnoux, Valérie Biran, Olivier Baud
BACKGROUND: Perinatal lung growth is highly vulnerable to inflammation and intrauterine growth restriction (IUGR), two major risk factors for chronic lung disease (CLD) in preterm neonates. However, the balance between extremely low gestational age (ELGA) and IUGR in very preterm infants as risk factors for CLD and co-morbidities remains poorly explored. OBJECTIVES: This single-center study aims to compare neonatal morbidity (including CLD) and mortality among ELGA infants with normal birth weight (ELGA-AGA), very preterm infants with IUGR <3rd percentile (VLGA-IUGR) and very preterm infants with a birth weight appropriate for gestational age (VLGA-AGA), matched with VLGA-IUGR infants...
2014: Neonatology
https://www.readbyqxmd.com/read/23282443/wheezing-in-infancy
#5
Yehia M El-Gamal, Shereen S El-Sayed
Several population-based birth cohort studies documented that 30% of children suffer from wheezing during respiratory infections before their third birthday. Infants are prone to wheeze because of anatomic factors related to the lung and chest wall in addition to immunologic and molecular influences in comparison to older children. Viral infections lead to immunologic derangements that cause wheezing both in immunocompetent and immunodeficient infants. Anatomic causes of wheeze may be extrinsic or intrinsic to the airway...
May 2011: World Allergy Organization Journal
https://www.readbyqxmd.com/read/22592683/inhaled-versus-systemic-corticosteroids-for-preventing-chronic-lung-disease-in-ventilated-very-low-birth-weight-preterm-neonates
#6
REVIEW
Sachin S Shah, Arne Ohlsson, Henry L Halliday, Vibhuti S Shah
BACKGROUND: Chronic lung disease (CLD) remains an important cause of mortality and morbidity in preterm infants and inflammation plays an important role in its pathogenesis. The use of inhaled corticosteroids may modulate the inflammatory process without concomitant high systemic steroid concentrations and less risk of adverse effects. OBJECTIVES: To determine the effect of inhaled versus systemic corticosteroids started within the first two weeks of life on preventing CLD in ventilated very low birth weight (VLBW) infants...
May 16, 2012: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/22592682/inhaled-versus-systemic-corticosteroids-for-the-treatment-of-chronic-lung-disease-in-ventilated-very-low-birth-weight-preterm-infants
#7
REVIEW
Sachin S Shah, Arne Ohlsson, Henry L Halliday, Vibhuti S Shah
BACKGROUND: Chronic lung disease (CLD) remains a serious and common problem among very low birth weight (VLBW) infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome. Due to their anti-inflammatory properties, corticosteroids have been widely used to treat or prevent CLD. However, the use of systemic steroids has been associated with serious short and long-term adverse effects. Administration of corticosteroids topically through the respiratory tract might result in beneficial effects on the pulmonary system with fewer undesirable systemic side effects...
May 16, 2012: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/22592680/early-administration-of-inhaled-corticosteroids-for-preventing-chronic-lung-disease-in-ventilated-very-low-birth-weight-preterm-neonates
#8
REVIEW
Vibhuti S Shah, Arne Ohlsson, Henry L Halliday, Michael Dunn
BACKGROUND: Chronic lung disease remains a common complication among preterm infants. There is increasing evidence that inflammation plays an important role in the pathogenesis of CLD. Due to their strong anti-inflammatory properties, corticosteroids are an attractive intervention strategy. However, there are growing concerns regarding short and long-term effects of systemic corticosteroids. Theoretically, administration of inhaled corticosteroids may allow for beneficial effects on the pulmonary system with a lower risk of undesirable systemic side effects...
May 16, 2012: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/21328574/socio-economic-factors-and-outcomes-in-chronic-lung-disease-of-prematurity
#9
COMPARATIVE STUDY
J Michael Collaco, SeEun Jennifer Choi, Kristin A Riekert, Michelle N Eakin, Sharon A McGrath-Morrow, Sande O Okelo
RATIONALE: Infants and children with chronic lung disease of prematurity (CLDP) are at increased risk for respiratory morbidities. We sought to determine (1) whether socio-economic status, race/ethnicity, and/or sex are risk factors for respiratory morbidities and (2) whether disparities in care existed for major therapy decisions such as home supplemental oxygen and gastrostomy tubes as well as initial length of stay in the neonatal intensive care unit. METHODS: Between January 2008 and February 2010 sociodemographic and respiratory morbidity data were collected on premature (<32 weeks gestation) infants and children (<3 years old) with CLDP...
July 2011: Pediatric Pulmonology
https://www.readbyqxmd.com/read/20091533/withdrawn-inhaled-steroids-for-neonatal-chronic-lung-disease
#10
REVIEW
Paula Lister, Richard Iles, Ben Nj Shaw, Francine M Ducharme
BACKGROUND: Bronchopulmonary dysplasia (BPD) is a chronic disorder associated with prematurity. Systemic steroids induce at least a temporary improvement in respiratory function, but are associated with adverse side effects. Inhaled steroids have fewer side effects. OBJECTIVES: To determine if inhaled corticosteroids are effective in alleviating the morbidity of bronchopulmonary dysplasia (BPD) compared to placebo. SEARCH STRATEGY: We identified randomised, controlled trials (RCT) within the Cochrane Database, references from retrieved trials, hand searches of journals and contact with pharmaceutical companies and experts in this field...
2010: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/19410441/-glucocorticoide-therapy-in-premature-infants-french-practices-in-2006
#11
E Autret-Leca, S Bauer, C Alberti, A-P Jonville-Béra, Y Aujard, L Bensouda-Grimaldi, O Baud
BACKGROUND AND AIM: In 1999, 80% of French neonatal centers used corticosteroids, mainly betamethasone (BMT), to prevent or treat bronchopulmonary dysplasia (BPD) [Lee SK, McMillan DD, Ohlson A, et al. Variations in practice and outcomes in the canadian NICU Network 1996-1997. Pediatrics 2000;106:1070-9]. As many data suggested a low risk-benefit ratio, an updated assessment of this use was necessary [Desnoulez L, Empana J, Anceschi M, et al. Prise en charge de l'immaturité pulmonaire en néonatologie : enquête sur les pratiques européennes...
July 2009: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/19336371/patterns-of-respiratory-disease-during-the-first-2-postnatal-weeks-in-extremely-premature-infants
#12
Matthew Laughon, Elizabeth N Allred, Carl Bose, T Michael O'Shea, Linda J Van Marter, Richard A Ehrenkranz, Alan Leviton
BACKGROUND: Pulmonary disease among infants of <28 weeks' gestation (extremely low gestational age newborns) often has the following pattern: the infant starts out with little need for supplemental oxygen and ventilatory support in the first postnatal week but then has pulmonary deterioration in the second postnatal week, with an increased need for supplemental oxygen and respiratory support. We evaluated the antecedents and correlates of patterns of early lung disease, with particular emphasis on pulmonary deterioration, in a large cohort study (the Extremely Low Gestational Age Newborn [ELGAN] study)...
April 2009: Pediatrics
https://www.readbyqxmd.com/read/18534620/one-year-respiratory-outcomes-of-preterm-infants-enrolled-in-the-nitric-oxide-to-prevent-chronic-lung-disease-trial
#13
RANDOMIZED CONTROLLED TRIAL
Anna Maria Hibbs, Michele C Walsh, Richard J Martin, William E Truog, Scott A Lorch, Evaline Alessandrini, Avital Cnaan, Lisa Palermo, Sandra R Wadlinger, Christine E Coburn, Philip L Ballard, Roberta A Ballard
OBJECTIVE: To identify whether inhaled nitric oxide treatment decreased indicators of long-term pulmonary morbidities after discharge from the neonatal intensive care unit. STUDY DESIGN: The Nitric Oxide (to Prevent) Chronic Lung Disease trial enrolled preterm infants (<1250 g) between 7 to 21 days of age who were ventilated and at high risk for bronchopulmonary dysplasia. Follow-up occurred at 12 +/- 3 months of age adjusted for prematurity; long-term pulmonary morbidity and other outcomes were reported by parents during structured blinded interviews...
October 2008: Journal of Pediatrics
https://www.readbyqxmd.com/read/18485272/systematic-review-and-economic-analysis-of-the-comparative-effectiveness-of-different-inhaled-corticosteroids-and-their-usage-with-long-acting-beta2-agonists-for-the-treatment-of-chronic-asthma-in-children-under-the-age-of-12-years
#14
REVIEW
C Main, J Shepherd, R Anderson, G Rogers, J Thompson-Coon, Z Liu, D Hartwell, E Loveman, C Green, M Pitt, K Stein, P Harris, G K Frampton, M Smith, A Takeda, A Price, K Welch, M Somerville
OBJECTIVES: To assess the clinical and cost-effectiveness of inhaled corticosteroids (ICS) alone and ICS used in combination with a long-acting beta2 agonist (LABA) in the treatment of chronic asthma in children aged under 12 years. DATA SOURCES: Major electronic bibliographic databases, e.g. MEDLINE and EMBASE, were searched up to February/March 2006 (and updated again in October 2006). REVIEW METHODS: A systematic review of clinical and cost-effectiveness studies and economic analyses were carried out...
May 2008: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/17943765/inhaled-versus-systemic-corticosteroids-for-the-treatment-of-chronic-lung-disease-in-ventilated-very-low-birth-weight-preterm-infants
#15
REVIEW
S S Shah, A Ohlsson, H Halliday, V S Shah
BACKGROUND: Chronic lung disease (CLD) remains a serious and common problem among very low birth weight infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome. Due to their anti-inflammatory properties, corticosteroids have been widely used to treat or prevent CLD. However, the use of systemic steroids has been associated with serious short and long-term adverse effects. Administration of corticosteroids topically through the respiratory tract might result in beneficial effects on the pulmonary system with fewer undesirable systemic side effects...
2007: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/17943764/early-administration-of-inhaled-corticosteroids-for-preventing-chronic-lung-disease-in-ventilated-very-low-birth-weight-preterm-neonates
#16
REVIEW
V Shah, A Ohlsson, H L Halliday, M S Dunn
BACKGROUND: Chronic lung disease remains a common complication among preterm infants. There is increasing evidence that inflammation plays an important role in the pathogenesis of CLD. Due to their strong anti-inflammatory properties, corticosteroids are an attractive intervention strategy. However, there are growing concerns regarding short and long-term effects of systemic corticosteroids. Theoretically, administration of inhaled corticosteroids may allow for beneficial effects on the pulmonary system with a lower risk of undesirable systemic side effects...
2007: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/16510650/prospective-evaluation-of-postnatal-steroid-administration-a-1-year-experience-from-the-california-perinatal-quality-care-collaborative
#17
Neil N Finer, Richard J Powers, Chia-hao Simon Ou, David Durand, David Wirtschafter, Jeffrey B Gould et al.
OBJECTIVE: Postnatal steroids (PNSs) are used frequently to prevent or treat chronic lung disease (CLD) in the very low birth weight (VLBW) infant, and their use continues despite concerns regarding an increased incidence of longer-term neurodevelopmental abnormalities in such infants. More recently, there has been a suggestion that corticosteroids may be a useful alternative therapy for hypotension in VLBW infants, but there have been no prospective reports of such use for a current cohort of VLBW infants...
March 2006: Pediatrics
https://www.readbyqxmd.com/read/15805348/a-pulmonary-score-for-assessing-the-severity-of-neonatal-chronic-lung-disease
#18
Ashima Madan, Beverly S Brozanski, Cynthia H Cole, Neal L Oden, Geoff Cohen, Dale L Phelps
BACKGROUND: Limited data are available to describe the spectrum of severity of neonatal chronic lung disease. In the multicenter Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of Prematurity trial, all infants had some degree of pulmonary dysfunction, because eligibility required a median oxygen saturation of < or =94% with room air. Infants randomized to the supplemental oxygen group (oxygen saturation target of 96-99%) had more pulmonary morbidity than did those in the conventional group (oxygen saturation target of 88-94%)...
April 2005: Pediatrics
https://www.readbyqxmd.com/read/15748968/management-of-infants-with-chronic-lung-disease-of-prematurity-in-chile
#19
REVIEW
Maria Angélica Palomino, Mónica Morgues, Fernando Martínez
Despite advances in the prevention and management of respiratory distress syndrome, chronic lung disease of prematurity (CLD) remains a major cause of morbidity and mortality in preterm babies in Chile. Its incidence varies from 10% to 60% in different regions of Chile. Since 1998, the management of CLD after discharge from neonatal unit follows national guidelines. Target oxygen saturation is 85% to 91% in the first 1 week of life, 91% to 94% from 1 to 2 weeks and over 95% after 44 weeks postconceptional age...
February 2005: Early Human Development
https://www.readbyqxmd.com/read/15717178/a-meta-analysis-of-ibuprofen-versus-indomethacin-for-closure-of-patent-ductus-arteriosus
#20
REVIEW
Ronald L Thomas, Graham C Parker, Bart Van Overmeire, Jacob V Aranda
UNLABELLED: Ibuprofen (IBU) has previously been shown to be as effective as indomethacin (INDO) in closing the patent ductus arteriosus (PDA) of preterm infants, without severely affecting renal hemodynamics or basal cerebral blood flow. We conducted a meta-analysis of randomized trials to compare the efficacy and safety of IBU and INDO for treatment of PDA. Data from the nine relevant trials ( n =566), showed no significant difference in the efficacy of IBU and INDO in PDA closure ( P =0...
March 2005: European Journal of Pediatrics
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