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elderly aging frailty

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https://www.readbyqxmd.com/read/28724399/health-needs-access-to-healthcare-and-perceptions-of-ageing-in-an-urbanizing-community-in-india-a-qualitative-study
#1
Nandita Bhan, Pavitra Madhira, Arundati Muralidharan, Bharati Kulkarni, Gvs Murthy, Sanjay Basu, Sanjay Kinra
BACKGROUND: India's elderly population is rising at an unprecedented rate, with a majority living in rural areas. Health challenges associated with ageing, changing social networks and limited public health infrastructure are issues faced by the elderly and caregivers. We examined perceptions of health needs of the elderly across local stakeholders in an urbanizing rural area. METHODS: The qualitative study was conducted among participants in the Andhra Pradesh Children and Parents Study (APCAPS) site in Rangareddy district, Telangana...
July 19, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28721433/oral-health-and-the-frail-elderly
#2
L Rapp, S Sourdet, B Vellas, M-H Lacoste-Ferré
INTRODUCTION: The relationships between oral health conditions and frailty have rarely been explored. A systematic review of frailty components and oral health concluded that differences in study population endpoint criteria and study design cannot establish a relationship between frailty and oral health. OBJECTIVE: This study aims to describe the distribution of the OHAT (Oral Health Assessment Tool) score in a population of frail subjects and to assess associated parameters (age, socio-economic status, living conditions, education level, nutritional habits, cognitive functioning, autonomy)...
2017: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/28721427/prevalence-of-frailty-in-nursing-home-residents-according-to-various-diagnostic-tools
#3
F Buckinx, J-Y Reginster, S Gillain, J Petermans, T Brunois, O Bruyère
BACKGROUND: Although the theoretical foundations of frailty are well established in the literature, it remains an evolving concept lacking any unique definition or diagnostic criteria for use in clinical practice and epidemiological research. No consensus exists about the accurate prevalence rates of frailty. The various operational definitions of frailty can at least partly explain such discrepancies. OBJECTIVE: To compare the prevalence of frailty, measured with different diagnostic tools, among elderly nursing home residents...
2017: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/28712144/frailty-is-an-independent-prognostic-marker-in-elderly-patients-with-myocardial-infarction
#4
Gonzalo Luis Alonso Salinas, Marcelo Sanmartin, Marina Pascual Izco, Luis Miguel Rincon, Pablo Pastor Pueyo, Alvaro Marco Del Castillo, Alberto Garcia Guerrero, Pedro Caravaca Perez, Alejandro Recio-Mayoral, Asuncion Camino, Manuel Jimenez-Mena, José Luis Zamorano
BACKGROUND: Acute coronary syndrome (ACS) patients are increasingly older. Conventional prognostic scales include chronological age but do not consider vulnerability. In elderly patients, a frail phenotype represents a better reflection of biological age. HYPOTHESIS: This study aims to determine the prevalence of frailty and its influence on patients age ≥75 years with ACS. METHODS: Patients age ≥75 years admitted due to type 1 myocardial infarction were included in 2 tertiary hospitals, and clinical data were collected prospectively...
July 16, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28709946/frailty-and-sarcopenia-do-not-predict-adverse-events-in-an-elderly-population-undergoing-non-complex-primary-elective-surgery-for-degenerative-conditions-of-the-lumbar-spine
#5
Raphaële Charest-Morin, John Street, Honglin Zhang, Taren Roughead, Tamir Ailon, Michael Boyd, Marcel Dvorak, Brian Kwon, Scott Paquette, Nicolas Dea, Charles G Fisher, Alana M Flexman
BACKGROUND CONTEXT: Sarcopenia measured by normalized total psoas area (NTPA) has been shown to predict mortality and adverse events (AE) in numerous surgical populations. The relationship between sarcopenia and postoperative outcomes after surgery for degenerative spine disease (DSD) has not been investigated. PURPOSE: This study aimed to determine the relationships between sarcopenia, frailty and postoperative adverse events in the elderly DSD population. Secondary objectives were to describe the distribution and predictors of NTPA and to determine the relationship between sarcopenia, frailty and length of stay, discharge to a facility and in-hospital mortality...
July 11, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28705733/platelet-oxidative-stress-as-a-novel-target-of-cardiovascular-risk-in-frail-older-people
#6
REVIEW
Francisco Fuentes, Iván Palomo, Eduardo Fuentes
The average lifespan of humans and the percentage of people entering the 65 and older age group are growing rapidly. Within this age group, cardiovascular diseases (CVD) increase steeply and are the most common cause of death. During aging, experimental and clinical studies support the pivotal role played by reactive oxidant species in the mechanism of platelet activation. Frailty has been implicated as a causative and prognostic factor in patients with CVD. Oxidative stress is increased in frail older people, and may lead to accelerated aging and higher incidence of oxidative diseases such as CVD...
July 10, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/28704826/dialysis-in-the-elderly-and-impact-of-institutionalization-in-the-united-states-renal-data-system
#7
Amarpali Brar, Mary Mallappallil, Dimitre G Stefanov, David Kau, Moro O Salifu
BACKGROUND: We hypothesized that in the very elderly dialysis patients in the United States, institutionalization in nursing homes would increase mortality in addition to age alone. METHODS: Incident dialysis patients from 2001 to 2008 above the age of 70 were included. Patients above 70 were categorized into 4 groups according to age as 70-75, 76-80, 81-85, and >85 years and further divided into institutionalized and noninstitutionalized. Kaplan-Meier survival curves were plotted to assess patient survival...
July 14, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28700679/aged-associated-cytomegalovirus-and-epstein-barr-virus-reactivation-and-cytomegalovirus-relationship-with-the-frailty-syndrome-in-older-women
#8
Ronaldo Luis Thomasini, Daniele Sirineu Pereira, Fabiana Souza Máximo Pereira, Elvis Cueva Mateo, Thamires Nader Mota, Gabrielle Gontijo Guimarães, Leani Souza Máximo Pereira, Cristiano Xavier Lima, Mauro Martins Teixeira, Antônio Lúcio Teixeira
Immunosenescence is an age-related reduction of immune system activity that can be associated with frailty. This study aimed to compare cytomegalovirus (CMV) and Epstein-Barr virus (EBV) reactivations (based on viremias) between young and elderly women who had a chronic CMV and/or EBV infection (i.e., an IgG+ serostatus) without an acute infection (i.e., an IgM- serostatus), and among the elderly group categorized according to frailty status. DNA was extracted from plasma using standard protocols and serostatus was determined by enzyme-linked immunosorbent assay...
2017: PloS One
https://www.readbyqxmd.com/read/28690038/-transfusion-in-elderly-take-account-frailty
#9
R Mahmoudi, J-L Novella, Y Jaïdi
The conjunction of the demographic aging and the increase in the frequency of anemia with the advancing age, mean that the number of globular concentrates delivered each year increases with a consequent heavy pressure on blood collection. The etiologies of anemia in the elderly are often multifactorial and their investigation is an indispensable step and prior to any treatment. Transfusion thresholds, particularly in the elderly, are gradually evolving and a so-called restrictive strategy is now favored. Immediate and delayed complications of transfusion are more frequent in the elderly due to vulnerability factors associated with frailty and the risk of multiple transfusions...
July 6, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28688079/self-perceived-care-needs-in-older-adults-with-joint-pain-and-comorbidity
#10
Lotte A H Hermsen, Emiel O Hoogendijk, Johannes C van der Wouden, Martin Smalbrugge, Stephanie S Leone, Henriëtte E van der Horst, Joost Dekker
BACKGROUND: The aim of this study was to explore self-perceived care needs and determinants of identified needs in older adults with joint pain and comorbidity. METHODS: This is a cross-sectional study using baseline data from a cohort study of older adults in the Netherlands (≥65 years) with joint pain and comorbidity (n = 407). We used the Camberwell Assessment of Need for the Elderly (CANE) to assess self-perceived care needs. Regression analyses were conducted to examine the associations between needs and sociodemographic factors (age, gender, partner status and educational level), physical factors (pain intensity, comorbidity, frailty and physical functioning) and psychosocial factors (anxiety, depression and social support)...
July 7, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28684438/five-year-follow-up-after-transcatheter-aortic-valve-implantation-for-symptomatic-aortic-stenosis
#11
Ralf Zahn, Nicolas Werner, Ulrich Gerckens, Axel Linke, Horst Sievert, Philipp Kahlert, Rainer Hambrecht, Stefan Sack, Mohamed Abdel-Wahab, Ellen Hoffmann, Uwe Zeymer, Steffen Schneider
OBJECTIVES: Transcatheter aortic valve implantation (TAVI) has been implemented into the care of elderly patients suffering from severe symptomatic aortic stenosis. However, data on long-term follow-up are sparse and predictors of long-term mortality need to be evaluated to better select patients. Therefore, we aimed to analyse predictors of 5-year mortality after TAVI. METHODS: We analysed data from the German Transcatheter Aortic Valve Interventions-Registry. Each of the 27 participating hospitals agreed to include all consecutive TAVI patients at their institution...
July 6, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28683406/crimes-against-the-elderly-in-italy-2007-2014
#12
Claudio Terranova, Greta Bevilacqua, Margherita Zen, Massimo Montisci
Crimes against the elderly have physical, psychological, and economic consequences. Approaches for mitigating them must be based on comprehensive knowledge of the phenomenon. This study analyses crimes against the elderly in Italy during the period 2007-2014 from an epidemiological viewpoint. Data on violent and non-violent crimes derived from the Italian Institute of Statistics were analysed in relation to trends, gender and age by linear regression, T-test, and calculation of the odds ratio with a 95% confidence interval...
June 27, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28675572/association-between-frailty-and-carotid-intima-media-thickness-and-inflammatory-marker-in-an-elderly-population
#13
Chun-Chin Chang, Chien-Yi Hsu, Po-Hsun Huang, Li-Kuo Liu, Liang-Kung Chen, Jaw-Wen Chen, Shing-Jong Lin
AIM: Frailty is a highly prevalent geriatric syndrome, characterized by increased vulnerability to subsequent morbidity and mortality. The association between frailty and preclinical atherosclerosis remains uncertain. The aim of the present study was to clarify the relationship between frailty, preclinical atherosclerosis and inflammatory markers in older adults. METHODS: We enrolled 1798 inhabitants of I-Lan County of Taiwan (855 men, 47.5%; mean age 64 ± 9 years, range 50-92 years)...
July 4, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28668143/prognosis-impact-of-frailty-assessed-by-the-edmonton-frail-scale-in-the-setting-of-acute-coronary-syndrome-in-the-elderly
#14
Stéphanie Blanco, Jean Ferrières, Vanina Bongard, Olivier Toulza, Fatia Sebai, Sophie Billet, Caroline Biendel, Olivier Lairez, Thibault Lhermusier, Nicolas Boudou, Francisco Campelo-Parada, Jérôme Roncalli, Michel Galinier, Didier Carrié, Meyer Elbaz, Frédéric Bouisset
BACKGROUND: Elderly patients represent a large proportion of patients admitted for acute coronary syndrome (ACS). Whether frailty-defined as a biological syndrome that reflects a state of decreased physiological reserve and vulnerability to stressors-may impact the clinical outcomes in this population remains unclear. We aimed to determine the prevalence of frailty and its impact on mortality in patients aged ≥ 80 years admitted for ACS. METHODS: This prospective observational study was conducted in patients aged 80 years or older admitted to a tertiary hospital for ACS...
July 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28663354/feeding-the-microbiota-transducer-of-nutrient-signals-for-the-host
#15
REVIEW
Fergus Shanahan, Douwe van Sinderen, Paul W O'Toole, Catherine Stanton
Advances in microbiome science cast light on traditional concepts on nutritional science, and are poised for clinical translation. Epidemiologic observations which linked lifestyle factors to risk of disease are being re-interpreted with mechanistic insight based on improved understanding of the microbiota. Examples include the role of dietary fibre in disease prevention, the deleterious effects of highly restricted diets, and the contribution of the microbiota to over- and undernutrition. While the microbiota transduces nutrient signals for the host, food and habitual diet shape the composition of the gut microbiota at every stage of life...
June 29, 2017: Gut
https://www.readbyqxmd.com/read/28647579/frailty-is-associated-with-lower-expression-of-genes-involved-in-cellular-response-to-stress-results-from-the-toledo-study-for-healthy-aging
#16
Mariam El Assar, Javier Angulo, José Antonio Carnicero, Stefan Walter, Francisco José García-García, Eva López-Hernández, José-María Sánchez-Puelles, Leocadio Rodríguez-Mañas
BACKGROUND: Specific mechanisms underlying frailty syndrome are not well known. Frailty can be viewed as a loss of functional reserve resulting in increased vulnerability to stressors. We hypothesize that pathways regulating cellular response to stress are potential players in the development of frailty. The aim of this study was to evaluate the association of the expression of certain genes related to cellular response to stress with the presence of frailty in older patients. METHODS: A sample of 350 individuals aged 65 years or older (22% frail) was selected from the Toledo Study of Healthy Aging...
June 21, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28633440/low-alanine-aminotransferase-levels-in-the-elderly-frailty-disability-sarcopenia-and-reduced-survival
#17
Umberto Vespasiani-Gentilucci, Antonio De Vincentis, Luigi Ferrucci, Stefania Bandinelli, Raffaele Antonelli Incalzi, Antonio Picardi
Background: Although low alanine aminotransferase (ALT) levels have been associated with poor outcomes in the elderly, the determinants subtending this association have been poorly explored. To gain insight into this topic, we analyzed data from a prospective population-based database (InCHIANTI study) in which frailty, disability, sarcopenia and pyridoxine levels were systematically assessed. Methods: Data are from 765 participants aged >65 years (mean age 75...
June 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28633404/agreement-between-35-published-frailty-scores-in-the-general-population
#18
Gloria A Aguayo, Anne-Françoise Donneau, Michel T Vaillant, Anna Schritz, Oscar H Franco, Saverio Stranges, Laurent Malisoux, Michèle Guillaume, Daniel R Witte
In elderly populations, frailty is associated with higher mortality risk. Although many frailty scores (FS) have been proposed, no single score is considered the gold standard. We aimed to evaluate the agreement between a wide range of FS in the English Longitudinal Study of Ageing (ELSA). Through a literature search, we identified 35 FS that could be calculated in ELSA wave 2 (2004-2005). We examined agreement between each frailty score and the mean of 35 FS, using a modified Bland-Altman model and Cohen's kappa (κ)...
June 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28628498/earlier-physical-therapy-input-is-associated-with-a-reduced-length-of-hospital-stay-and-reduced-care-needs-on-discharge-in-frail-older-inpatients-an-observational-study
#19
Peter J Hartley, Victoria L Keevil, Ledia Alushi, Rebecca L Charles, Eimear B Conroy, Patricia M Costello, Becki Dixon, Aida M Dolinska-Grzybek, Diana Vajda, Roman Romero-Ortuno
BACKGROUND AND PURPOSE: Pressures on hospital bed occupancy in the English National Health Service have focused attention on enhanced service delivery models and methods by which physical therapists might contribute to effective cost savings, while retaining a patient-centered approach. Earlier access to physical therapy may lead to better outcomes in frail older inpatients, but this has not been well studied in acute National Health Service hospitals. Our aim was to retrospectively study the associations between early physical therapy input and length of hospital stay (LOS), functional outcomes, and care needs on discharge...
June 16, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/28625932/frailty-in-elderly-a-brief-review
#20
Maturin Tabue-Teguo, Nadine Simo, Magali Gonzalez-Colaço Harmand, Matteo Cesari, Jose-Alberto Avila-Funes, Catherine Féart, Hélène Amiéva, Jean-François Dartigues
The identification of frail older persons is a public health priority. Frailty is defined as an extreme vulnerability of the organism to endogenous and exogenous stressors, a syndrome that exposes the individual at higher risk of negative health-related outcomes as well as a transition phase between successful aging and disability. The theoretical concept of frailty is largely agreed, its practical translation still presents some limitations due to the existence of multiple tools and operational definition...
June 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
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