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elderly aging frailty

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https://www.readbyqxmd.com/read/28527626/the-impact-of-economic-conditions-on-the-disablement-process-a-markov-transition-approach-using-share-data
#1
Y Arrighi, T Rapp, N Sirven
A growing number of studies underline the relationship between socioeconomic status and health at older ages. Following that literature, we explore the impact of economic conditions on changes in functional health overtime. Frailty, a state of physiological instability, has been identified in the public health literature as a candidate for disability prevention but received little attention from health economists. Using SHARE panel data, respondents aged 50 and over from ten European countries were categorised as robust, frail and dependent...
May 10, 2017: Health Policy
https://www.readbyqxmd.com/read/28525586/prevalence-and-correlates-of-frailty-among-community-dwelling-chinese-older-adults-the-china-health-and-retirement-longitudinal-study
#2
Chenkai Wu, Ellen Smit, Qian-Li Xue, Michelle C Odden
Background.: Frailty is an age-related clinical syndrome of decreased resilience to stressors and is associated with numerous adverse outcomes. Although there is preponderance of literature on frailty in developed countries, limited investigations have been conducted in less developed regions including China-a country that has the world's largest aging population. We examined frailty prevalence in China by socio-demographics and geographic region, and investigated correlates of frailty...
May 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28510786/the-impact-of-frailty-on-noninvasive-mechanical-ventilation-in-elderly-medical-intensive-care-unit-patients
#3
Iskender Kara, F Yildirim, A Zerman, Z Gullu, N Boyaci, B B Aydogan, U Gaygisiz, K Gonderen, G Arik, M Turkoglu, M Aydogdu, G Aygencel, Z Ulger, G Gursel
AIM: Many factors affecting noninvasive ventilation (NIV) in critically ill patients have been reported in the literature, but there is no study about the effect of frailty. With this study, the frailty prevalence was evaluated with two different frailty scores among the NIV population of a medical intensive care unit (ICU). Besides, the impact of frailty on NIV success and mortality and its association with NIV application problems were evaluated. METHOD: A prospective observational cohort study was performed on patients who were over 50 years of age and assigned to NIV due to hypercapnic respiratory failure...
May 16, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28505140/self-management-group-exercise-extends-healthy-life-expectancy-in-frail-community-dwelling-older-adults
#4
Minoru Yamada, Hidenori Arai
Preventing frailty and its adverse health outcomes is crucial in countries with a large elderly population, such as Japan. Since the long-term care insurance (LTCI) system was launched, the number of certified older adults with LTCI service requirement has continued to increase. This is a serious problem, because the LTCI service requirement certification is equivalent to disability. The aim of this study was to evaluate the effect of a self-management group intervention on new LTCI service requirement certifications in community-dwelling older adults in Japan...
May 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28496545/c-reactive-protein-and-frailty-in-the-elderly-a-literature-review
#5
REVIEW
Dimitrios Velissaris, Nikolaos Pantzaris, Ioanna Koniari, Nikolaos Koutsogiannis, Vasilios Karamouzos, Ioanna Kotroni, Anastasia Skroumpelou, John Ellul
Chronic inflammation is a well-established background process in many age-related diseases. Many recent studies investigate the use of various inflammatory biomarkers such as C-reactive protein (CRP), interleukin-6, and interleukin-1 as predictors of physical and cognitive performance among elders. The phenotype of frailty has also been associated with underlying inflammatory mechanisms. The aim of this article was to review the literature referring to the correlation of CRP serum levels and frailty in older individuals...
June 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28493811/pooled-analysis-of-individual-patient-data-on-concurrent-chemoradiotherapy-for-stage-iii-non-small-cell-lung-cancer-in-elderly-patients-compared-with-younger-patients-who-participated-in-us-national-cancer-institute-cooperative-group-studies
#6
Thomas E Stinchcombe, Ying Zhang, Everett E Vokes, Joan H Schiller, Jeffrey D Bradley, Karen Kelly, Walter J Curran, Steven E Schild, Benjamin Movsas, Gerald Clamon, Ramaswamy Govindan, George R Blumenschein, Mark A Socinski, Neal E Ready, Wallace L Akerley, Harvey J Cohen, Herbert H Pang, Xiaofei Wang
Purpose Concurrent chemoradiotherapy is standard treatment for patients with stage III non-small-cell lung cancer. Elderly patients may experience increased rates of adverse events (AEs) or less benefit from concurrent chemoradiotherapy. Patients and Methods Individual patient data were collected from 16 phase II or III trials conducted by US National Cancer Institute-supported cooperative groups of concurrent chemoradiotherapy alone or with consolidation or induction chemotherapy for stage III non-small-cell lung cancer from 1990 to 2012...
May 11, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28487242/oxidative-stress-genomic-features-and-dna-repair-in-frail-elderly-a-systematic-review
#7
REVIEW
María Sánchez-Flores, Diego Marcos-Pérez, Solange Costa, João Paulo Teixeira, Stefano Bonassi, Eduardo Pásaro, Blanca Laffon, Vanessa Valdiglesias
Frailty is an emerging geriatric syndrome characterized by higher vulnerability to stressors, with an increased risk of adverse health outcomes such as mortality, morbidity, disability, hospitalization, and institutionalization. Although it is generally recognized to have a biological basis, no particular biological trait has been consistently associated to frailty status so far. In this work, epidemiological studies evaluating association of frailty status with alterations at cellular level - namely oxidative stress, genomic instability and DNA damage and repair biomarkers -were revised and compared...
May 6, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28478840/alzheimer-s-disease-and-other-neurodegenerative-diseases-may-be-due-to-nutritional-deficiencies-secondary-to-unrecognized-exocrine-pancreatic-insufficiency
#8
Steven R Brenner
Alzheimer's disease (AD) may be related to nutritional deficiencies from exocrine pancreatic insufficiency (EPI) with mal-absorption of essential nutrients, vitamins and minerals. EPI occurs in about twenty percent of the elderly population, sometimes without obvious symptoms, a number similar to the incidence of AD. Other Neurological degenerative diseases with potential nutritional components such as Parkinson's disease, frailty of age and Multiple Sclerosis, a disease with increased activity from vitamin D deficiency, may also be related to untreated exocrine pancreatic insufficiency causing impaired absorption of essential dietary elements...
May 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28475664/dynamical-resilience-indicators-in-time-series-of-self-rated-health-correspond-to-frailty-levels-in-older-adults
#9
Sanne M W Gijzel, Ingrid A van de Leemput, Marten Scheffer, Mattia Roppolo, Marcel G M Olde Rikkert, René J F Melis
Background: We currently still lack valid methods to dynamically measure resilience for stressors before the appearance of adverse health outcomes that hamper well-being. Quantifying an older adult's resilience in an early stage would aid complex decision-making in health care. Translating complex dynamical systems theory to humans, we hypothesized that three dynamical indicators of resilience (variance, temporal autocorrelation, and cross-correlation) in time series of self-rated physical, mental, and social health were associated with frailty levels in older adults...
May 5, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28471943/clinical-implications-of-aging-with-hiv-infection-perspectives-and-the-future-medical-care-agenda
#10
Giovanni Guaraldi, Frank J Palella
: The increasing number of aging HIV-infected (HIV+) persons comprises a unique population at risk for illnesses and syndromes traditionally associated with the elderly. As a result, similar to the current need for primary care providers to manage chronic noninfectious comorbidities among aging persons with well controlled HIV infection, HIV clinical care will need to routinely involve geriatric medicine in a new HIV-geriatric discipline. The objective of this article is to provide a conceptual framework in which HIV and geriatric management considerations for healthcare professionals caring for HIV+ persons are integrated...
June 1, 2017: AIDS
https://www.readbyqxmd.com/read/28463202/gait-velocity-and-chair-sit-stand-sit-performance-improves-current-frailty-status-identification
#11
Nora Millor, Pablo Lecumberri, Marisol Gomez, Alicia Martinez-Ramirez, Ion Martinikorena, Leocadio Rodriguez-Manas, Francisco Garcia Garcia, Mikel Izquierdo
Frailty is characterized by a loss of functionality and is expected to affect 9.9% of people aged 65 and over. Here, current frailty classification is compared to a collection of selected kinematic parameters. A total of 718 elderly subjects (319 males and 399 females; age: 75.4 ± 6.1 years), volunteered to participate in this study and were classified according to Fried´s criteria. Both the 30-s chair stand test (CST) and the 3-m walking test were performed and a set of kinematic parameters were obtained from a single inertial unit...
April 27, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28436194/impact-of-living-arrangements-on-clinical-outcomes-among-older-patients-with-dementia-or-cognitive-impairment-admitted-to-the-geriatric-evaluation-and-management-unit-in-taiwan
#12
Cheng-Hao Hung, Ting-Ching Tang, Chih-Jen Wang, Li-Kuo Liu, Li-Ning Peng, Liang-Kung Chen
AIM: To evaluate the impact of living arrangements on mortality and functional decline among older patients with dementia or cognitive impairment after discharge from a geriatric evaluation and management unit (GEMU) in Taiwan. METHODS: The present retrospective cohort study used data from the Veteran Affairs Comprehensive Geriatric Assessment from January 2015 to May 2016 for analysis. Data of patients aged 65 years and older with dementia or cognitive impairment at admission to the GEMU of Taipei Veterans General Hospital during the study period were retried for study...
April 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28423084/immune-system-dysfunction-in-the-elderly
#13
Eduardo Fuentes, Manuel Fuentes, Marcelo Alarcón, Iván Palomo
Human aging is characterized by both physical and physiological frailty that profoundly affects the immune system. In this context aging is associated with declines in adaptive and innate immunity established as immunosenescence. Immunosenescence is a new concept that reflects the age-associated restructuring changes of innate and adaptive immune functions. Thus elderly individuals usually present chronic low-level inflammation, higher infection rates and chronic diseases. A study of alterations in the immune system during aging could provide a potentially useful biomarker for the evaluation of immune senescence treatment...
January 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28419681/oral-mycobiome-in-community-dwelling-elderly-and-its-relation-to-oral-and-general-health-conditions
#14
Myrna Nurlatifah Zakaria, Michiko Furuta, Toru Takeshita, Yukie Shibata, Rini Sundari, Nobuoki Eshima, Toshiharu Ninomiya, Yoshihisa Yamashita
OBJECTIVE: Oral fungal infection is generally associated with dysbiosis related to antibiotic use, immunodeficiency, or frailty. However, fungal colonization in a typical population without apparent symptoms, and its associated conditions are poorly understood. In this study, oral fungal colonization in community-dwelling and independently living elderly populations was evaluated and factors affecting fungal colonization were analyzed. SUBJECTS AND METHODS: The subjects (410; 181 males and 229 females) were 75-99 years of age; those under prior antibiotic use were excluded...
April 18, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28413012/-identifying-frailty-and-the-importance-of-personalised-support
#15
Mathilde Nicolas, Régis Gonthier, Émilie Crawford-Achour
Over recent years, many hospitals have been looking to promote optimum ageing by developing a strategy for identifying frailty in elderly people. This raises the question of prevention in the field of ageing and the capacities to change behaviour which is harmful to health at any age. Early and long-term support is essential.
March 2017: Soins. Gérontologie
https://www.readbyqxmd.com/read/28411349/effect-of-low-appendicular-lean-mass-grip-strength-and-gait-speed-on-the-functional-outcome-after-surgery-for-distal-radius-fractures
#16
Young Hak Roh, Jung Ho Noh, Hyun Sik Gong, Goo Hyun Baek
Patients with low appendicular lean mass plus slow gait speed or weak grip strength are at risk for poor functional recovery after surgery for distal radius fracture, even when they have similar radiologic outcomes. INTRODUCTION: Loss of skeletal muscle mass and consequent loss in muscle function associate with aging, and this condition negatively impacts the activities of daily living and increases elderly individuals' frailty to falls. Thus, patients with low appendicular lean mass would show different functional recovery compared to those without this condition after surgery for distal radius fracture (DRF)...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28406166/office-based-simple-frailty-score-and-central-blood-pressure-predict-mild-cognitive-impairment-in-an-apparently-healthy-japanese-population-j-shipp-study
#17
Maya Ohara, Katsuhiko Kohara, Yoko Okada, Masayuki Ochi, Tokihisa Nagai, Yasumasa Ohyagi, Yasuharu Tabara, Michiya Igase
Frailty is associated with cognitive impairment and can be used to identify people at high risk for dementia. We developed a simple frailty (SF) score using a combination of low hand grip strength (<32.5 kg in men, <19.5 kg in women), and short one-leg standing time (<20 seconds). These can be easily measured in the clinician's office when seeing patients. We investigated the possible association between SF score and mild cognitive impairment (MCI) in a cross-sectional study with 838 independent middle-aged to elderly participants (319 men, mean age 65...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28405820/higher-dietary-acid-load-is-associated-with-a-higher-prevalence-of-frailty-particularly-slowness-weakness-and-low-physical-activity-in-elderly-japanese-women
#18
Yuki Kataya, Kentaro Murakami, Satomi Kobayashi, Hitomi Suga, Satoshi Sasaki
OBJECTIVE: Epidemiologic evidence on the potential effects of dietary acid load on frailty is lacking. This cross-sectional study examined the association between dietary acid load and frailty. METHODS: This study was based on self-reported data obtained from 2176 Japanese women aged 65-94 years. Dietary acid load was characterized as potential renal acid load (PRAL) and net endogenous acid production (NEAP), based on information on nutrient intake, obtained from a validated brief diet history questionnaire...
April 12, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28399218/timed-up-and-go-predicts-functional-decline-in-older-patients-presenting-to-the-emergency-department-following-minor-trauma%C3%A2
#19
Debra Eagles, Jeffrey J Perry, Marie-Josée Sirois, Eddy Lang, Raoul Daoust, Jacques Lee, Lauren Griffith, Laura Wilding, Xavier Neveu, Marcel Emond
Background: there is no standardised test for assessing mobility in the Emergency Department (ED). Objective: we wished to evaluate the relationship between the Timed Up and Go (TUG) and frailty, functional decline and falls in community dwelling elders that present to the ED following minor trauma. Methods: this was a secondary analysis of a prospective cohort study conducted at eight Canadian hospitals. Evaluations included: TUG; Study of Osteoporotic Fractures Frailty Index; Older American Resources and Service Functional Scale; and self-reported falls...
March 1, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28395196/body-composition-and-frailty-profiles-in-brazilian-older-people-frailty-in-brazilian-older-people-study-fibra-br
#20
Eduardo Ferriolli, Fernanda Pinheiro Amador Dos Santos Pessanha, Virgílio Garcia Moreira, Rosângela Corrêa Dias, Anita Liberalesso Neri, Roberto Alves Lourenço
OBJECTIVE: To determine the association between body composition and frailty in older Brazilian subjects. MATERIAL AND METHODS: This is a Cross-sectional study called FIBRA-BR and developed in community Brazilian aged ≥65 (n=5638). Frailty was assessed according to Fried et al. definition and body composition was determined by BMI, waist circumference and waist-hip ratio. RESULTS: The lowest prevalence of frailty was observed in subjects with BMI between 25...
March 27, 2017: Archives of Gerontology and Geriatrics
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