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elderly aging frailty

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https://www.readbyqxmd.com/read/29331842/predicting-1-year-disability-and-mortality-of-injured-older-adults
#1
Alvin D Jeffery, Mary S Dietrich, Cathy A Maxwell
PURPOSE: The growing incidence of elderly patients injured from falls, combined with a growing understanding of the contribution of cognition and frailty to mortality, prompted this work. Our objective was to develop a clinical risk prediction model for prognosticating disability and mortality among injured older adults 1 year after hospitalization. METHODS: Secondary analysis of prospective longitudinal data from an urban Level 1 trauma center. A proportional odds regression model was used to model mortality and functional status as ordinal outcomes...
January 6, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29323208/composition-of-salivary-microbiota-in-elderly-subjects
#2
Taiji Ogawa, Yujiro Hirose, Mariko Honda-Ogawa, Minami Sugimoto, Satoshi Sasaki, Masahito Kibi, Shigetada Kawabata, Kazunori Ikebe, Yoshinobu Maeda
Frailty is gaining attention worldwide with the aging of society. Despite the potential lethality and multiple signs and symptoms in affected individuals, preclinical detection of early manifestations leading to frailty syndrome have not been established. We speculated that the composition of the oral microbiota is associated with general frailty, as well as a relationship between gut microbiota and general health condition. In the present study, we investigated the salivary microbiota composition in samples from healthy and frail elderly individuals using 16S rRNA sequencing analysis for characterization...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29318084/how-does-frailty-factor-into-mortality-risk-assessment-of-a-middle-aged-and-geriatric-trauma-population
#3
Sanjit R Konda, Ariana Lott, Hesham Saleh, Sebastian Schubl, Jeffrey Chan, Kenneth A Egol
Introduction: Frailty in elderly trauma populations has been correlated with an increased risk of morbidity and mortality. The Score for Trauma Triage in the Geriatric and Middle-Aged (STTGMA) is a validated mortality risk score that evaluates 4 major physiologic criteria: age, comorbidities, vital signs, and anatomic injuries. The aim of this study was to investigate whether the addition of additional frailty variables to the STTGMA tool would improve risk stratification of a middle-aged and elderly trauma population...
December 2017: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/29300426/physical-frailty-is-associated-with-longitudinal-decline-in-global-cognitive-function-in-non-demented-older-adults-a-prospective-study
#4
S Chen, T Honda, K Narazaki, T Chen, H Kishimoto, Y Haeuchi, S Kumagai
OBJECTIVES: To assess the relationship between physical frailty and subsequent decline in global cognitive function in the non-demented elderly. DESIGN AND SETTING: A prospective population-based study in a west Japanese suburban town, with two-year follow-up. PARTICIPANTS: Community-dwellers aged 65 and older without placement in long-term care, and not having a history of dementia, Parkinson's disease and depression at baseline, who participated in the cohort of the Sasaguri Genkimon Study and underwent follow-up assessments two years later (N = 1,045)...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29290100/circulating-levels-of-monocyte-chemoattractant-protein-1-as-a-potential-measure-of-biological-age-in-mice-and-frailty-in-humans
#5
Matthew J Yousefzadeh, Marissa J Schafer, Nicole Noren Hooten, Elizabeth J Atkinson, Michele K Evans, Darren J Baker, Ellen K Quarles, Paul D Robbins, Warren C Ladiges, Nathan K LeBrasseur, Laura J Niedernhofer
A serum biomarker of biological versus chronological age would have significant impact on clinical care. It could be used to identify individuals at risk of early-onset frailty or the multimorbidities associated with old age. It may also serve as a surrogate endpoint in clinical trials targeting mechanisms of aging. Here, we identified MCP-1/CCL2, a chemokine responsible for recruiting monocytes, as a potential biomarker of biological age. Circulating monocyte chemoattractant protein-1 (MCP-1) levels increased in an age-dependent manner in wild-type (WT) mice...
December 31, 2017: Aging Cell
https://www.readbyqxmd.com/read/29285733/relationship-between-masticatory-function-and-frailty-in-community-dwelling-japanese-elderly
#6
Yasuhiro Horibe, Yutaka Watanabe, Hirohiko Hirano, Ayako Edahiro, Ken Ishizaki, Takayuki Ueda, Kaoru Sakurai
BACKGROUND: Frailty likely results in impaired functioning, and frail individuals requiring long-term care have recently attracted the attention of researchers. In the oral health field, the number of elderly individuals who require intervention for retaining occlusion has been increasing, as has the number of remaining teeth and required prosthetic treatment. Additionally, the number of elderly with reduced masticatory function has also been increasing, and frailty is a suspected factor...
December 28, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29285609/functional-compromise-cohort-study-fccs-sarcopenia-is-a-strong-predictor-of-mortality-in-the-intensive-care-unit
#7
P A de Hoogt, K W Reisinger, J J W Tegels, J W A M Bosmans, F Tijssen, J H M B Stoot
BACKGROUND: Functional compromise in elderly patients is considered to be a significant contributing factor in increased postoperative morbidity and mortality. It is described as a state of reduced physiologic reserves including, e.g., sarcopenia, cachexia, malnutrition and frailty with increased susceptibility to adverse health outcomes. Aim of this study was to investigate the association of sarcopenia with mortality in ICU patients. METHODS: A retrospective analysis of a total of 687 patients admitted to the ICU from January 2013 until December 2014 was performed...
December 29, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29282602/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-the-elderly-is-it-reasonable-a-meta-analysis
#8
Johan Gagnière, Julie Veziant, Bruno Pereira, Denis Pezet, Bertrand Le Roy, Karem Slim
BACKGROUND: Whether cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) is safe and worthwhile for elderly patients remains unclear. This meta-analysis of outcomes after CRS plus HIPEC for the elderly aimed to generate a higher level of evidence and precise indications for these patients. METHODS: A systematic literature search for studies reporting postoperative outcomes after CRS plus HIPEC for elderly patients was performed in the MEDLINE, Cochrane Central Register of Controlled Trials, ClinicalTrials...
December 28, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29282000/the-association-between-anemia-and-falls-in-community-living-women-and-men-aged-65-years-and-older-from-the-fifth-troms%C3%A3-study-2001-02-a-replication-study
#9
Laila Arnesdatter Hopstock, Elisabeth Bøe Utne, Alexander Horsch, Tove Skjelbakken
BACKGROUND: Falls are common among elderly people, and the risk increase with age. Falls are associated with both health and social consequences for the patient, and major societal costs. Identification of risk factors should be investigated to prevent falls. Previous studies have shown anemia to be associated with increased risk of falling, but the results are inconsistent. The aim of this study was to investigate the association between anemia and self-reported falls among community-living elderly people...
December 27, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29260588/upfront-treatment-of-elderly-myeloma-patients-an-overview-and-update
#10
Hussein G Elsayed, Amal S Alabdulwahab
Multiple myeloma is primarily a disease of older age, with a median age of 70 years at diagnosis. Management of the disease in this diverse population is challenging, in the face comorbidities and frailties. Areas covered: This review discusses the management challenges of elderly myeloma patients in view of the current evidence and propose for performing a formal objective assessment of the functional status to guide choice of treatment. Expert commentary: The approval of many antimyeloma medications with various mechanisms of action in the past two decades had sparked the debate about choosing the best combination, duration of therapy, role of transplant and the possibility to cure myeloma after being changed to a chronic disease...
December 20, 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/29247531/effects-of-acute-phase-intensive-electrical-muscle-stimulation-in-frail-elderly-patients-with-acute-heart-failure-active-ems-rationale-and-protocol-for-a-multicenter-randomized-controlled-trial
#11
Shinya Tanaka, Kentaro Kamiya, Yuya Matsue, Ryusuke Yonezawa, Hiroshi Saito, Nobuaki Hamazaki, Ryota Matsuzawa, Kohei Nozaki, Kazuki Wakaume, Yoshiko Endo, Emi Maekawa, Minako Yamaoka-Tojo, Takaaki Shiono, Takayuki Inomata, Takashi Masuda, Junya Ako
In elderly patients with acute heart failure (AHF), clinical outcome is adversely affected by frailty. Although a number of potentially effective interventions for frailty have been reported, little is known about the effects of rehabilitation programs in frail elderly AHF patients. We postulated that addition of electrical muscle stimulation (EMS), which induces muscle contraction without requiring patient volition, to early rehabilitation would be efficacious in frail elderly AHF patients. The ACTIVE-EMS (Effects of Acute Phase Intensive Electrical Muscle Stimulation in Frail Elderly Patients With AHF; UMIN000019551) trial is a multicenter, randomized controlled trial that will enroll 80 patients from 3 hospitals in Japan...
December 16, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/29236162/bisphosphonates-prevent-age-related-weight-loss-in-japanese-postmenopausal-women
#12
Tomohiko Urano, Masataka Shiraki, Tatsuhiko Kuroda, Shiro Tanaka, Fumihiko Urano, Kazuhiro Uenishi, Satoshi Inoue
Decline of body weight with aging is a major risk factor for frailty, osteoporosis and fracture, suggesting that treatment for osteoporosis may affect body composition. Recently, we have shown that 5-year treatment with raloxifene prevented age-related weight loss, suggesting some other drugs for osteoporosis may also prevent a decrease in body weight with aging. The present study aimed to identify the relationship between bisphosphonate treatment and body composition markers. We measured bone mineral density (BMD), body composition, and bone remodeling markers in 551 Japanese postmenopausal women with bisphosphonate treatment, which included risedronate or alendronate treatment (BP-treatment group; N = 193) and without treatment by any osteoporosis drug (no-treatment group; N = 358) for 4-7 years (mean observation periods; 5...
December 13, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29230719/resveratrol-and-or-exercise-training-counteract-aging-associated-decline-of-physical-endurance-in-aged-mice-targeting-mitochondrial-biogenesis-and-function
#13
Marwa Hassan Muhammad, Mona Maher Allam
Mitochondrial dysfunction and decreased mitochondrial content are hallmarks of aging that leads to decreased physical endurance. Our aim was to explore the anti-aging effect of resveratrol (RSVT) supplementation, a polyphenol, and/or exercise training, started at an older age, on improving physical activity, therefore, help in frailty avoidance and promotion of healthy aging in elderly. Eighteen-month-old aged mice received RSVT (15 mg/kg/day) and/or exercise trained for 4 weeks showed significant longer time to exhaustion with decreased blood lactate and free fatty acids levels associated with improved oxidative stress evidenced by decreased gastrocnemius muscle lipid peroxidation and increased antioxidant enzymes activities, catalase and superoxide dismutase, when compared to aged mice control group...
December 11, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29229199/microbiota-and-aging-a-review-and-commentary
#14
REVIEW
Carmen García-Peña, Teresa Álvarez-Cisneros, Ricardo Quiroz-Baez, Robert P Friedland
Although there is a consensus that the dominant species that make up the adult microbiota remains unchanged in elderly people, it has been reported that there are significant alterations in the proportion and composition of the different taxa, leading to reduced microbiota diversity, as well as an increase of enteropathogens that may lead to chronic inflammation. The ageing of mucosal immune and motor systems also contributes to these changes. As the individual ages, there is a loss in the number of Peyer's patches, an altered local capacity of T and B cell functions as well as chronic macrophage activation...
December 8, 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29225254/observational-study-of-infective-endocarditis-at-a-community-based-hospital-dominance-of-elderly-patients-with-comorbidity
#15
Tomoo Nagai, Yoshiyuki Takase, Akira Hamabe, Hirotsugu Tabata
Objective The purpose of this study was to present the recent clinical profiles and the real-world management of infective endocarditis (IE). Methods All medical records of patients with IE were reviewed retrospectively for their clinical data, including clinical presentation, laboratory results, blood cultures, echocardiographic findings, treatments and complications. Using the clinical data collected, we calculated the EuroSCORE II, the European risk score for adult cardiac surgery, the Charlson Comorbidity Index as a surrogate of comordibity, and the Katz Index as a surrogate of frailty...
December 8, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29220527/inverse-association-between-neck-pain-and-all-cause-mortality-in-community-dwelling-older-adults
#16
Antonio Muscari, Giampaolo Bianchi, Paola Forti, Donatella Magalotti, Paolo Pandolfi, Marco Zoli
Objective: In a previous study, we found an apparent protective effect of neck pain on all-cause mortality in subjects older than age 85 years. The present longitudinal investigation was performed to verify this unexpected finding in a larger sample and to establish its significance. Design: Population follow-up study. Setting: Three towns of Northern Italy. Subjects: We examined 5,253 community-dwelling residents age 65-102 years (55% female)...
December 6, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29214924/different-protein-and-derivatives-supplementation-strategies-combined-with-resistance-training-in-pre-frail-and-frail-elderly-rationale-and-protocol-for-the-pro-elderly-study
#17
Alan Lins Fernandes, Ana Paula Hayashi, José Claudio Jambassi-Filho, Mariana Dutilh de Capitani, Davi Alves de Santana, Bruno Gualano, Hamilton Roschel
BACKGROUND: Frailty is a multifactorial geriatric syndrome characterized by progressive decline in health and associated with decreased muscle mass, strength, and functional capacity. Resistance training (RT) combined with protein or amino acids supplementation has been shown to be promising for mitigating age-related impairments. AIM: To investigate the chronic effects of different strategies of protein and derivatives supplementation in association with RT on selected health-related parameters in pre-frail and frail elderly...
December 2017: Nutrition and Health
https://www.readbyqxmd.com/read/29213155/frailty-syndrome-and-socioeconomic-and-health-characteristics-among-older-adults
#18
Darlene Mara Dos Santos Tavares, Thais Aline de Freitas Corrêa, Flavia Aparecida Dias, Pollyana Cristina Dos Santos Ferreira, Maycon Sousa Pegorari
Objective: To investigate the association of frailty syndrome with socioeconomic and health variables among older adults. Methods: This is a cross-sectional, observational and analytical household research conducted with a sample of 1,609 urban elderly. We used: semi-structured questionnaire, scales (Katz, Lawton and shortened version of Geriatric Depression Scale) and Fragility Phenotype proposed by Fried. Descriptive analysis was performed along with a bivariate and multinomial logistic regression model (p <0...
September 30, 2017: Colombia Médica: CM
https://www.readbyqxmd.com/read/29211233/elderly-caregivers-living-in-urban-rural-and-high-social-vulnerability-contexts
#19
Sofia Cristina Iost Pavarini, Anita Liberalesso Neri, Allan Gustavo Brígola, Ana Carolina Ottaviani, Érica Nestor Souza, Estefani Serafim Rossetti, Mariélli Terassi, Nathalia Alves de Oliveira, Bruna Moretti Luchesi
OBJECTIVE Comparing the differences in the sociodemographic, care and health profiles of elderly caregivers of the elderly living in urban, rural, and high social vulnerability contexts. METHOD A cross-sectional study developed with elderly caregivers enrolled in the Family Health Units of a municipality in the interior of São Paulo. Household interviews and evaluations were conducted on: Activities of Daily Living (ADL), self-reported pain, frailty, cognition, life satisfaction, family functionality, burden, stress and hope...
2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/29211116/high-burden-and-frailty-association-with-poor-cognitive-performance-in-older-caregivers-living-in-rural-areas
#20
Allan Gustavo Brigola, Bruna Moretti Luchesi, Tiago da Silva Alexandre, Keika Inouye, Eneida Mioshi, Sofia Cristina Iost Pavarini
INTRODUCTION: Older caregivers living in rural areas may be exposed to three vulnerable conditions, i.e., those related to care, their own aging, and their residence context. OBJECTIVE: To analyze the association of burden and frailty with cognition performance in older caregivers in rural communities. METHOD: In this cross-sectional survey, 85 older caregivers who cared for dependent elders were included in this study. Global cognition (Addenbrooke's Cognitive Examination - Revised; Mini Mental State Examination), burden (Zarit Burden Interview) and frailty (Fried's frailty phenotype) were assessed...
December 4, 2017: Trends in Psychiatry and Psychotherapy
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