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elderly aging frailty

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https://www.readbyqxmd.com/read/28804010/frailty-and-malnutrition-related-and-distinct-syndrome-prevalence-and-association-among-community-dwelling-older-adults-singapore-longitudinal-ageing-studies
#1
Kai Wei, Ma Shwe Zin Nyunt, Qi Gao, Shiou Liang Wee, Tze-Pin Ng
OBJECTIVE: The association between frailty and malnutrition is widely noted, but the common and distinct aspects of this relationship are not well understood. We investigated the prevalence of prefrailty/frailty and malnutrition/nutritional risk; their overlapping prevalence; compared their sociodemographic, physical, and mental health risk factors; and assessed their association, independently of other risk factors. METHODS: Cross-sectional study of population-based cohort (Singapore Longitudinal Ageing Study [SLAS]-1 [enrolled 2003-2005] and SLAS-2 [enrolled 2010-2013]) of community-dwelling older Singaporeans aged ≥55 (n = 6045)...
August 10, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28802765/disparities-in-care-for-elderly-women-with-endometrial-cancer-adversely-effects-survival
#2
Anna Torgeson, Dustin Boothe, Matthew M Poppe, Gita Suneja, David K Gaffney
PURPOSE: Elderly women with endometrial cancer are at increased risk of local recurrence and cancer-specific death compared to younger women. We sought to investigate adjuvant radiotherapy (RT) practice patterns and effects on survival in elderly women with endometrial cancer. METHODS: Women from the National Cancer Data Base (NCDB) with FIGO IA grade 3 to FIGO IVA endometrial cancer diagnosed from 2004-2013 were included. Chi square analysis was used to compare the elderly (80+) and non-elderly women (18-79) and women who received RT and those that did not...
August 9, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28801236/frailty-status-in-older-adults-is-related-to-alterations-in-indoleamine-2-3-dioxygenase-1-and-guanosine-triphosphate-cyclohydrolase-i%C3%A2-enzymatic-pathways
#3
Diego Marcos-Pérez, María Sánchez-Flores, Ana Maseda, Laura Lorenzo-López, José C Millán-Calenti, Barbara Strasser, Johanna M Gostner, Dietmar Fuchs, Eduardo Pásaro, Vanessa Valdiglesias, Blanca Laffon
BACKGROUND: Frailty is a multidimensional syndrome correlated to the loss of homeostasis and increased vulnerability to stressors, which is associated with increase in the risk of disability, comorbidity, hospitalization, and death in the elderly. It is based on the interplay of physiological, psychological, social, and environmental factors. OBJECTIVES: Because aging involves a detrimental immune response, this work aimed to assess the possible role of chronic low-grade immune stimulation on frailty status in the elderly...
August 8, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28798441/minimal-intervention-management-of-the-older-patient
#4
L J Walsh
With an aging population, dentists need to be aware of the risks which come to their elderly patients from retained teeth and exposed root surfaces. Oral health problems in the later years of life are multifactorial, with lifestyle, plaque and salivary factors remaining paramount. Root surface caries is likely to present a challenge in patients with a strong history of past coronal caries (and who have the attendant lifestyle risk factors) as well as in elderly patients who suddenly develop salivary hypofunction...
August 11, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28793104/frailty-in-the-elderly-prevalence-and-associated-factors
#5
Jair Almeida Carneiro, Rafael Rodrigues Cardoso, Meiriellen Silva Durães, Maria Clara Araújo Guedes, Frederico Leão Santos, Fernanda Marques da Costa, Antônio Prates Caldeira
Objective: to know the prevalence and factors associated with frailty in elderly assisted by the Centro Mais Vida de Referência em Assistência à Saúde do Idoso (Mais Vida Health Reference Center for the Elderly) in the North of Minas Gerais, Brazil. Method: cross-sectional study, with sampling by convenience. Data collection occurred in 2015. Demographic and socioeconomic variables, morbidities, use of health services and the score of the Edmonton Frail Scale were analyzed...
July 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28790349/association-between-frailty-and-hypertension-prevalence-treatment-and-control-in-the-elderly-korean-population
#6
Min-Gu Kang, Sun-Wook Kim, Sol-Ji Yoon, Jung-Yeon Choi, Kwang-Il Kim, Cheol-Ho Kim
Frailty is a common geriatric syndrome characterized by increased risk of disability, hospitalization, and mortality. Hypertension (HTN) is one of the most common chronic medical conditions in the elderly. However, there have been few studies regarding the association between frailty and HTN prevalence, treatment, and control rates. We analyzed data of 4,352 older adults (age ≥ 65 years) from the fifth Korea National Health and Nutrition Examination Survey. We constructed a frailty index based on 42 items and classified participants as robust, pre-frail, or frail...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28790226/effect-of-metformin-on-handgrip-strength-gait-speed-myostatin-serum-level-and-health-related-quality-of-life-a-double-blind-randomized-controlled-trial-among-non-diabetic-pre-frail-elderly-patients
#7
Purwita Wijaya Laksmi, Siti Setiati, Tirza Z Tamin, Pradana Soewondo, Wasilah Rochmah, Nafrialdi Nafrialdi, Joedo Prihartono
BACKGROUND: sarcopenia contributes to the development of frailty syndrome. Frailty syndrome is potentially improved by modifying insulin resistance, inflammation, and myostatin level. This study is aimed to investigate the effect of metformin on handgrip strength, gait speed, myostatin serum level, and health-related quality of life (HR-QoL) among non-diabetic pre-frail elderly patients. METHODS: a double blind randomized controlled trial study was conducted on non-diabetic elderly outpatients aged ≥ 60 years with pre-frail status based on phenotype and/ or index criteria (Cardiovascular Health Study and/ or Frailty Index 40 items) consecutively recruited from March 2015 to June 2016 at Cipto Mangunkusumo Hospital...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28777289/sarcopenia-increases-risk-of-long-term-mortality-in-elderly-patients-undergoing-emergency-abdominal-surgery
#8
Erika L Rangel, Arturo J Rios-Diaz, Jennifer W Uyeda, Manuel Castillo-Angeles, Zara Cooper, Olubode A Olufajo, Ali Salim, Aaron D Sodickson
BACKGROUND: Frailty is associated with poor surgical outcomes in elderly patients but is difficult to measure in the emergency setting. Sarcopenia, or the loss of lean muscle mass, is a surrogate for frailty and can be measured using cross-sectional imaging. We sought to determine the impact of sarcopenia on one-year mortality after emergency abdominal surgery in elderly patients. METHODS: Sarcopenia was assessed in patients ≥70 years old who underwent emergency abdominal surgery at a single hospital from 2006-2011...
August 3, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28776468/falls-the-adverse-drug-reaction-of-the-elderly-and-the-impact-of-pharmacogenetics
#9
Katja Susanne Just, Katharina Luise Schneider, Marlen Schurig, Julia Carolin Stingl, Jürgen Brockmöller
Falls is a frequent type of adverse drug reactions causing significant morbidity and mortality in the elderly. We reviewed, with which drugs the risk of falls is relevant and might depend on genomic variation. Pharmacogenetic variability may contribute to drug-induced falls for instance mediated by impaired drug elimination due to inherited deficiency in enzymes like CYP2C9, CYP2C19 and CYP2D6. The relative role of specific genes and polymorphisms in old age may differ from younger people. Biomarkers for frailty, but also genomic biomarkers might help identifying patients at high risk for drug-induced falls...
August 4, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28776287/the-significance-of-frailty-in-the-relationship-between-socioeconomic-status-and-health-related-quality-of-life-in-the-korean-community-dwelling-elderly-population-mediation-analysis-with-bootstrapping
#10
Ho-Joong Kim, Saejong Park, Soo-Hyun Park, Young Woo Heo, Bong-Soon Chang, Choon-Ki Lee, Jin S Yeom
PURPOSE: Firstly, to investigate the prevalence of frailty and impact on health-related quality of life (HRQOL) in a Korean community-dwelling elderly population using the Fried frailty criteria; secondly, to investigate the associations among frailty, socioeconomic status (SES), and HRQOL of the Korean community-based population; and thirdly, to analyze the relationship between education, income, and frailty. METHODS: Nine hundred and sixty-four apparently heathy subjects from the Korean community-based population were enrolled in this prospective cross-sectional study...
August 3, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28763363/ovarian-cancer-in-elderly-patients-patterns-of-care-and-treatment-outcomes-according-to-age-and-modified-frailty-index
#11
Annamaria Ferrero, Luca Fuso, Elisa Tripodi, Roberta Tana, Alberto Daniele, Valentina Zanfagnin, Stefania Perotto, Angiolo Gadducci
OBJECTIVE: The present study assessed the predictive value of age and Modified Frailty Index (mFI) on the management of primary epithelial ovarian cancer (EOC) patients aged 70 years or older (elderly). METHODS: A retrospective multicenter study selected elderly EOC patients treated between 2006 and 2014. Treatments were analyzed according to the following age group categories: (1) 70 to 75 years versus (2) older than 75 years, and mFI of less than 4 (low frailty) versus greater than or equal to 4 (high frailty)...
August 1, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28763310/elderly-patients-with-multiple-myeloma-towards-a-frailty-approach
#12
Sonja Zweegman, Monika Engelhardt, Alessandra Larocca
PURPOSE OF REVIEW: To describe how to better identify frail multiple myeloma patients and to treat them appropriately. RECENT FINDINGS: Proteasome inhibitors, such as bortezomib, carfilzomib, and ixazomib, and immunomodulatory agents (IMiDs), such as thalidomide, lenalidomide, and pomalidomide, have significantly improved the outcome of multiple myeloma patients in the last decade. However, both in clinical trials and in daily clinical practice, elderly multiple myeloma patients have shown lesser benefit...
July 29, 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/28762937/-risk-of-cardiovascular-complications-and-geriatric-syndromes-among-elderly-women
#13
V N Larina, N K Runikhina, B Y Bart, I I Chukaeva, D G Karpenko
AIM: to assess the prevalence of some geriatric syndromes and their association with high risk of cardiovascular complications (RCVC) among elderly women. MATERIAL AND METHODS: We examined 72 women aged 69-77 years with cardiovascular diseases. Examination included laboratory and echocardiography assessment, dual-energy X-ray absorptiometry, 6-min walk test, assessment of psycho-emotional status using Mini-mental State Examination (MMSE) questionnaire. Frailty was defined as three or more of the following: weight loss, low physical activity levels, MMSE less or equal 23 points, weakness (chair stand test>10 sec), history of multiple falls...
March 2017: Kardiologiia
https://www.readbyqxmd.com/read/28762840/prevention-in-the-elderly-a-necessary-priority-for-general-practitioners
#14
Christos Lionis, Patrik Midlöv
Prevention is viewed as a key issue for general practice, yet there is a lack of evidence regarding general practitioners' interventions in both middle-aged and elderly people. This is despite the fact that recommendations and key indicators for monitoring the use of clinical preventive strategies aimed at these groups are available and that both the World Health Organization and European Commission endorse the importance of interventions for healthy and active ageing. This paper draws on two keynote presentations given at the 2015 autumn meeting of the European General Practice Research Network (EGPRN) in Edirne, Turkey (17-20 October 2015)...
December 2017: European Journal of General Practice
https://www.readbyqxmd.com/read/28762628/prognostic-value-of-physical-function-tests-and-muscle-mass-in-elderly-hospitalized-patients-a-prospective-observational-study
#15
Rubén Hernández-Luis, Esther Martín-Ponce, María Monereo-Muñoz, Geraldine Quintero-Platt, Silvia Odeh-Santana, Emilio González-Reimers, Francisco Santolaria
AIM: To determine the prognostic value for mortality of physical function tests, muscle mass loss, disability and frailty in elderly hospitalized patients. METHODS: We prospectively included 298 hospitalized patients aged >60 years (152 men and 146 women). We assessed comorbidity using the Charlson Comorbidity Index; nutrition by body mass index, midarm muscle area and subjective nutritional score; physical muscle function by handgrip strength, gait speed, standing balance and stand up test; disability using the Barthel test and activities of daily living; frailty by the clinical frailty scale and Fried frailty index; and cognitive impairment by the Pfeiffer test...
August 1, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28760658/frailty-body-composition-and-nutritional-status-in-non-institutionalised-elderly
#16
Leonel São Romão Preto, Maria do Carmo Dias Conceição, Telma Martins Figueiredo, Maria Augusta Pereira Mata, Pedro Miguel Barreira Preto, Ester Mateo Aguilar
OBJECTIVE: Frailty is a clinical syndrome characterized, among other signs, by involuntary weight loss and decreased muscle strength. The aim of this study was to analyse associations between frailty, body composition and nutritional status in non-institutionalised elderly people in the municipality of Alfândega (Braganza-Portugal). METHOD: Observational, prevalence and association study involving 220 elderly (mean 75.8±6.8 years of age; 68.8% women). Frailty was assessedt according to Fried criteria, body composition by bioelectrical impedance analysis and nutritional status using the Mini Nutritional Assessment Short-Form...
July 28, 2017: Enfermería Clínica
https://www.readbyqxmd.com/read/28757332/prediction-of-the-incidence-of-falls-and-deaths-among-elderly-nursing-home-residents-the-senior-study
#17
Fanny Buckinx, Jean-Louis Croisier, Jean-Yves Reginster, Céline Lenaerts, Théo Brunois, Xavier Rygaert, Jean Petermans, Olivier Bruyère
OBJECTIVE: The objective of this study was to evaluate, among nursing home residents, the extent to which the various operational definitions of frailty predict mortality and falls at 1 year. METHODS: We studied 662 participants from the Sample of Elderly Nursing home Individuals: An Observational Research (SENIOR) cohort aged 83.2 ± 8.99 years, including 484 (72.5%) women and living in nursing homes. Among this cohort, 584 and 565 participants, respectively, were monitored over 12 months for mortality assessment and for occurrence of falls (ie, by mean of their medical records)...
July 27, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28756048/frailty-assessments-in-surgical-practice-what-is-frailty-and-how-can-it-be-used-in-prosthetic-health
#18
REVIEW
Matthew S Brennan, Ryan M Barlotta, Jay Simhan
INTRODUCTION: Surgical frailty is a previously unrecognized clinical entity that objectifies a multiorgan decrease in physiologic reserve in those undergoing surgery. Although penile implantation has been demonstrated to be an effective means of restoring erectile function in patients whose previous conservative measures have failed, there are limited data regarding the assessment of frailty in patients undergoing penile implantation. AIM: To review the various objective methods used to describe surgical frailty in medical and surgical disciplines, report on methodologies of frailty assessment, and discuss the relevance of surgical frailty in the preoperative evaluation of patients undergoing implantation of an inflatable penile prosthesis...
July 26, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28755453/frailty-as-a-risk-factor-for-falls-among-community-dwelling-people-evidence-from-a-meta-analysis
#19
Mei-Hsun Cheng, Shu-Fang Chang
PURPOSE: This study was conducted to investigate the relationships between different frailty stages and the fall incidence rates of community-dwelling older adults. The differences between various frailty indicators regarding assessment accuracy of the fall incidence rates of community-dwelling elders were also analyzed. Finally, the relationship between frailty and recurrent falls was explored. METHODS: This study comprised a systematic literature review and meta-analysis...
July 29, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28751850/anmco-sic-sici-gise-sicch-executive-summary-of-consensus-document-on-risk-stratification-in-elderly-patients-with-aortic-stenosis-before-surgery-or-transcatheter-aortic-valve-replacement
#20
Giovanni Pulignano, Michele Massimo Gulizia, Samuele Baldasseroni, Francesco Bedogni, Giovanni Cioffi, Ciro Indolfi, Francesco Romeo, Adriano Murrone, Francesco Musumeci, Alessandro Parolari, Leonardo Patanè, Paolo Giuseppe Pino, Annalisa Mongiardo, Carmen Spaccarotella, Roberto Di Bartolomeo, Giuseppe Musumeci
Aortic stenosis is one of the most frequent valvular diseases in developed countries, and its impact on public health resources and assistance is increasing. A substantial proportion of elderly people with severe aortic stenosis is not eligible to surgery because of the advanced age, frailty, and multiple co-morbidities. Transcatheter aortic valve implantation (TAVI) enables the treatment of very elderly patients at high or prohibitive surgical risk considered ineligible for surgery and with an acceptable life expectancy...
May 2017: European Heart Journal Supplements: Journal of the European Society of Cardiology
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