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elderly aging frailty

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https://www.readbyqxmd.com/read/29792992/frailty-status-as-a-predictor-of-three-month-cognitive-and-functional-recovery-following-spinal-surgery-a-prospective-pilot-study
#1
Robert J Rothrock, Jeremy M Steinberger, Henry Badgery, Andrew C Hecht, Samuel K Cho, John M Caridi, Stacie Deiner
Background Context As increasing numbers of elderly Americans undergo spinal surgery, it is important to identify which patients are at highest risk for poor cognitive and functional recovery. Frailty is a geriatric syndrome which has been closely linked to poor outcomes, and short form screening may be a helpful tool for preoperative identification of at risk patients. Purpose To conduct a pilot study on the usefulness of a short-form screening tool to identify elderly patients at increased risk for prolonged cognitive and functional recovery following elective spine surgery...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29789408/the-relationship-between-serum-igf-1-handgrip-strength-physical-performance-and-falls-in-elderly-men-and-women
#2
Caroline Van Nieuwpoort, Mariska Vlot, Laura Schaap, Paul Lips, Madeleine Drent
OBJECTIVE: Human aging is accompanied by a decrease in growth hormone secretion and serum IGF-1 levels. Also, loss of muscle mass, strength and impairment of physical performance, ending in a state of frailty, are seen in elderly. We aimed to investigate whether handgrip strength, physical performance and recurrent falls are related to serum IGF-1 levels in community dwelling elderly. DESIGN: Observational cohort study (cross-sectional and prospective). METHODS: We studied the association between IGF-1 and handgrip strength, physical performance and falls in participants of the Longitudinal Aging Study Amsterdam...
May 22, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29785098/sarcopenia-assessment-of-disease-burden-and-strategies-to-improve-outcomes
#3
REVIEW
Ilaria Liguori, Gennaro Russo, Luisa Aran, Giulia Bulli, Francesco Curcio, David Della-Morte, Gaetano Gargiulo, Gianluca Testa, Francesco Cacciatore, Domenico Bonaduce, Pasquale Abete
Life expectancy is increasing worldwide, with a resultant increase in the elderly population. Aging is characterized by the progressive loss of skeletal muscle mass and strength - a phenomenon called sarcopenia. Sarcopenia has a complex multifactorial pathogenesis, which involves not only age-related changes in neuromuscular function, muscle protein turnover, and hormone levels and sensitivity, but also a chronic pro-inflammatory state, oxidative stress, and behavioral factors - in particular, nutritional status and degree of physical activity...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29784558/life-expectancy-in-elderly-patients-following-burns-injury
#4
Sarvnaz Sepehripour, Sirisha Duggineni, Somaya Shahsavari, Baljit Dheansa
INTRODUCTION: Burn injuries commonly occur in vulnerable age and social groups. Previous research has shown that frailty may represent a more important marker of adverse outcome in healthcare rather than chronological age (Roberts et al., 2012). In this paper we determined the relationship between burn injury, frailty, co-morbidities and long-term survival. METHODOLOGY: Retrospective data collection from patients aged 75 with burns injuries, treated and discharged at Queen Victoria Hospital...
May 18, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29776643/review-of-risk-assessment-tools-to-predict-morbidity-and-mortality-in-elderly-surgical-patients
#5
REVIEW
Gilgamesh Eamer, Mohamed J H Al-Amoodi, Jayna Holroyd-Leduc, Darryl B Rolfson, Lindsey M Warkentin, Rachel G Khadaroo
BACKGROUND: Informed surgical consent requires accurate estimation of risks and benefits. Multiple risk assessment tools are available; however, most are not widely used or are specific to certain interventions. Assessing surgical risk is especially challenging in elderly patients because of their range of comorbidities, level of frailty, or severity of illness and a number of available surgical interventions. DATA SOURCES: We searched MEDLINE from January 2014 to July 2017 for studies that used risk assessment tools in studies on elderly surgical patients...
April 18, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29772594/-upper-age-limit-in-outpatient-anesthesia-opportunities-and-risks
#6
Tobias Hüppe, Nicole Kneller, Alexander Raddatz
Ambulatory surgery in elderly patients continues to increase - avoiding hospitalization and thus postoperative cognitive dysfunction in older patients being its major objectives. An upper age limit in outpatient anesthesia does not exist to date. However, functional rather than chronological age is crucial in patient selection. In consensus discussion, baseline functional status should be evaluated regularly - defined as everyday behaviors necessary to maintain daily life and encompassing areas of physical, cognitive, and social functioning...
May 2018: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29760608/calf-circumference-as-a-simple-screening-marker-for-diagnosing-sarcopenia-in-older-korean-adults-the-korean-frailty-and-aging-cohort-study-kfacs
#7
Sunyoung Kim, Miji Kim, Yunhwan Lee, ByungSung Kim, Tai Young Yoon, Chang Won Won
Background: The purpose of this study was to explore the optimal cut-off point of calf circumference (CC) as a simple proxy marker of appendicular skeletal muscle mass (ASM) and sarcopenia in the Korean elderly and to test the criterion-related validity of CC by analyzing its relationships with the physical function. Methods: The participants were 657 adults aged 70 to 84 years who had completed both dual energy X-ray absorptiometry (DXA) and physical function test in the first baseline year of the Korean Frailty and Aging Cohort Study...
May 14, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29759834/utility-of-frailty-assessment-for-elderly-patients-undergoing-cardiac-resynchronization-therapy
#8
Maciej Kubala, Laurence Guédon-Moreau, Frédéric Anselme, Didier Klug, Geneviève Bertaina, Sarah Traullé, Otilia Buiciuc, Arnaud Savouré, Momar Diouf, Jean-Sylvain Hermida
OBJECTIVES: The aim of this study was to evaluate the impact of frailty in the elderly on response to cardiac resynchronization therapy (CRT). BACKGROUND: CRT has been shown to improve symptoms and outcome of patients with congestive heart failure (HF) and impaired left ventricular ejection fraction (LVEF). The impact of frailty on the results of CRT is unknown. METHODS: Frailty defined as <14 of 17 points using the ONCODAGE (Outil de dépistage gériatrique en oncologie) G8 score was assessed before device implantation in candidates for CRT who were >70 years of age...
December 26, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29753582/the-biomarkers-associated-with-sarcopenia-and-physical-frailty-in-elderly-persons-biosphere-study-rationale-design-and-methods
#9
Riccardo Calvani, Anna Picca, Federico Marini, Alessandra Biancolillo, Matteo Cesari, Vito Pesce, Angela Maria Serena Lezza, Maurizio Bossola, Christiaan Leeuwenburgh, Roberto Bernabei, Francesco Landi, Emanuele Marzetti
Sarcopenia, the progressive and generalised loss of muscle mass and strength/function, is a major health issue in older adults given its high prevalence and burdensome clinical implications. Over the years, this condition has been endorsed as a marker for discriminating biological from chronological age. However, the absence of a unified operational definition has hampered its full appreciation by healthcare providers, researchers and policy-makers. In addition to this unsolved debate, the complexity of musculoskeletal ageing represents a major challenge to the identification of clinically meaningful biomarkers...
May 10, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29741197/how-to-manage-frail-older-adults-in-the-community-proposal-of-a-health-promotion-program-experienced-in-a-city-of-16-638-inhabitants-in-france
#10
J de Kerimel, N Tavassoli, C Lafont, M Soto, M Pedra, F Nourhashemi, C Lagourdette, L Bouchon, A Chaléon, S Sourdet, Y Rolland, M Cesari, B Vellas
BACKGROUND: Health promotion programs could prevent and delay frailty and functional decline. However, in practice, the planning and establishment of such a program is a challenge for health care providers. We report an experimental model of screening and management for frail elderly conducted in Cugnaux, city of 16,638 inhabitants in France, by the Toulouse Gerontopole and the social care service of the Cugnaux City Hall. METHODS: A frailty screening self-administered questionnaire (FiND questionnaire) was sent to community-dwelling residents of 70 years old and over of Cugnaux...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29736782/exercise-attenuates-age-associated-changes-in-motoneuron-number-nucleocytoplasmic-transport-proteins-and-neuromuscular-health
#11
Ashley Gillon, Kathrine Nielsen, Charlotte Steel, Jon Cornwall, Philip Sheard
Life expectancy continues to extend, although frailty caused by loss of skeletal muscle mass continues unimpeded. Muscle atrophy caused by withdrawal of motor nerves is a feature of old age, as it is in amyotrophic lateral sclerosis (ALS) in which skeletal muscle denervation results from motoneuron death. In ALS, direct links have been established between motoneuron death and altered nucleocytoplasmic transport, so we ask whether similar defects accompany motoneuron death in normal ageing. We used immunohistochemistry on mouse tissues to explore potential links between neuromuscular junction (NMJ) degeneration, motoneuron death and nucleocytoplasmic transport regulatory proteins...
May 7, 2018: GeroScience
https://www.readbyqxmd.com/read/29734155/role-of-frailty-on-outcomes-of-dialysis-patients
#12
Kosaku Nitta, Norio Hanafusa, Ken Tsuchiya
Frailty is a clinical state in which there is an increase in the individual's vulnerability to developing increased dependency and/or mortality when exposed to a stressor. Since the mean age of dialysis patients is increasing worldwide, frailty has recently come to be considered one of the risk factors for mortality in the older dialysis population. The prevalence of frailty among dialysis patients has ranged from 3.0- to 10-fold higher than in community-dwelling elderly, depending on the method of assessing frailty and patient characteristics...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29731619/association-between-a-frailty-index-based-on-common-laboratory-tests-and-qtc-prolongation-in-older-adults-the-rugao-longevity-and-ageing-study
#13
Teng Ma, Jian Cai, Yin-Sheng Zhu, Xue-Feng Chu, Yong Wang, Guo-Ping Shi, Zheng-Dong Wang, Shun Yao, Xiao-Feng Wang, Xiao-Yan Jiang
Background: Risk factors for heart rate-corrected QT interval (QTc) proglongation should be explored to stratify high-risk individuals to aid the prevention of incident cardiovascular events and mortality. The diversity of risk factors for QTc prolongation suggests that use of the frailty index (FI), indicating general health deficits, may be an effective approach, especially in the elderly, to identify the risk of QTc prolongation. Methods: We used the data of 1,780 individuals aged 70-87 years from the Rugao Longevity and Ageing Study (RuLAS), a community-based longitudinal study...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29730983/the-challenge-of-aging-and-pharmacoterapeutic-complexity-in-the-hiv-patient
#14
Ramón Morillo-Verdugo, José Ramón Blanco Ramos, Laila Abdel-Kader Martín, María Álvarez de Sotomayor
OBJECTIVE: To describe the current knowledge and management of aging and  pharmacotherapeutic complexity in HIV + patients. METHOD: A review of literature was carried out, including articles, originals or  reviews, published in English or Spanish, from 2007 to 2017, which analysed the aging and pharmacotherapeutic complexity in HIV + patients. The terms  «Polypharmacy»/»Polypharmacy», «Aging»/»Aging», «Frailty»/»Fragility»,  «Pharmacotherapeutic Complexity»/»Medication Regimen Complexity» and  «HIV»/"HIV» were combined...
May 1, 2018: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/29729455/the-5-item-modified-frailty-index-is-predictive-of-30-day-postoperative-complications-in-patients-undergoing-kyphoplasty-vertebral-augmentation
#15
Dale Segal, Jacob M Wilson, Christopher Staley, Keith W Michael
BACKGROUND: Vertebral compression fractures are the most common spine injury seen in elderly patients. Vertebral augmentation is considered a safe and effective treatment. The ability to predict outcomes based on comorbidities is lacking. The modified frailty index has been used to predict complications after orthopedic and surgical procedures. We hypothesized that despite a low rate of adverse outcomes, postoperative complications following kyphoplasty would be higher in frail patients...
May 2, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29721782/herpes-zoster-in-frail-elderly-patients-prevalence-impact-management-and-preventive-strategies
#16
REVIEW
Ermanno Zorzoli, Francesca Pica, Giulia Masetti, Elisabetta Franco, Antonio Volpi, Giovanni Gabutti
Population aging is a worldwide phenomenon with significant and manifold impacts on society. Advanced age correlates with the onset of frailty. In this vulnerable state, the immune response is weakened and a higher susceptibility to infectious diseases is observed. The present narrative review aims to cover the topic of herpes zoster (HZ) and its complications in frail populations. The lifetime risk of developing HZ is estimated at about 20-30%, and the risk increases with age. In older people, HZ can lead to the inability to recover the lifestyle, the interests, and the level of activity that existed before its development...
May 2, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29719199/antioxidants-linked-with-physical-cognitive-and-psychological-frailty-analysis-of-candidate-biomarkers-and-markers-derived-from-the-mark-age-study
#17
M Liset Rietman, Annemieke M W Spijkerman, Albert Wong, Harry van Steeg, Alexander Bürkle, María Moreno-Villanueva, Thilo Sindlinger, Claudio Franceschi, Beatrix Grubeck-Loebenstein, Jürgen Bernhardt, P Eline Slagboom, Olivier Toussaint, Florence Debacq-Chainiaux, Ewa Sikora, Efstathios S Gonos, Nicolle Breusing, Wolfgang Stuetz, Daniela Weber, Tilman Grune, Andrea Basso, Francesco Piacenza, Marco Malavolta, Sebastiano Collino, Eugene H J M Jansen, W M Monique Verschuren, Martijn E T Dollé
Frailty among elderly people leads to an increased risk for negative health outcomes. To prevent frailty, we need a better understanding of the underlying mechanisms and early detection of individuals at risk. Both may be served by identifying candidate (bio)markers, i.e. biomarkers and markers, for the physical, cognitive, and psychological frailty domains. We used univariate (Rank-ANOVA) and multivariate (elastic net) approaches on the RASIG study population (age range: 35-74 years, n = 2220) of the MARK-AGE Study to study up to 331 (bio)markers between individuals with and without frailty for each domain...
April 29, 2018: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29718855/investigation-on-the-frailty-status-of-the-elderly-inpatients-in-shanghai-using-the-frail-fatigue-resistance-ambulation-illness-and-loss-questionnaire
#18
Yin Wei, Yanpei Cao, Xiaoli Yang, Yan Xu
This study was to investigate the frailty status of inpatients older than 65 years old in Shanghai.A 6-month cross-sectional survey was conducted using FRAIL (fatigue, resistance, ambulation, illness, and loss) questionnaire. Totally 587 patients were included. The data, including demographic characteristics, constipation, urinary retention, urinary incontinence, grip strength, and muscle strength, were collected. The data of serum prealbumin, serum albumin, serum total protein, and hemoglobin were obtained from laboratory blood tests...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29716551/sociodemographic-and-physical-predictors-of-non-participation-in-community-based-physical-checkup-among-older-neighbors-a-case-control-study-from-the-kyoto-kameoka-longitudinal-study-japan
#19
Miwa Yamaguchi, Tsukasa Yoshida, Yosuke Yamada, Yuya Watanabe, Hinako Nanri, Keiichi Yokoyama, Heiwa Date, Motoko Miyake, Aya Itoi, Emi Yamagata, Taeko Masumoto, Yasuko Okayama, Yasuko Yoshinaka, Misaka Kimura
BACKGROUND: It is difficult to obtain detailed information on non-participants in physical and health examination checkups in community-based epidemiological studies. We investigated the characteristics of non-participants in a physical and health examination checkup for older adults in a nested study from the Japanese Kyoto-Kameoka Longitudinal Study. METHODS: We approached a total of 4831 people aged ≥65 years in 10 randomly selected intervention regions. Participants responded to a mail-based population survey on needs in the sphere of daily life to encourage participation in a free face-to-face physical checkup examination; 1463 participants (706 men, 757 women) participated in the physical checkup...
May 2, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29712948/g-395a-polymorphism-in-the-promoter-region-of-the-klotho-gene-associates-with-frailty-among-the-oldest-old
#20
Qiukui Hao, Yuting Wang, Xiang Ding, Biao Dong, Ming Yang, Birong Dong, Yuquan Wei
Frailty is characterized by a decline in physiological reserve and increased vulnerability. Previous studies have shown that KLOTHO (KL) plays a protective role in several age-related diseases. We hypothesize a probable protective effect of KL on frailty in the elderly population and included a cohort of Chinese nonagenarians and centenarians for our study. This study is part of a cross-sectional study and secondary analysis of the Project of Longevity and Aging in Dujiangyan (PLAD) study, which was conducted in Southwest China...
April 30, 2018: Scientific Reports
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