keyword
https://read.qxmd.com/read/38536515/blood-pressure-in-preterm-infants-with-bronchopulmonary-dysplasia-in-the-first-three-months-of-life
#1
JOURNAL ARTICLE
Judit Klara Kiss, Anna Gajda, Judit Mari, Csaba Bereczki
BACKGROUND: Neonatal hypertension is common in preterm infants with bronchopulmonary dysplasia (BPD). Our study aimed to examine blood pressure variation in the first three months of life in preterm BPD patients. METHODS: We conducted a retrospective, single-centre study at the Neonatal Intensive Care Unit of the University of Szeged, Hungary. We collected blood pressure data from 26 preterm infants (born at < 30 weeks gestation) with moderate or severe BPD over three years (2019-2021)...
March 27, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38530413/risk-factors-associated-with-in-hospital-complications-for-pediatric-sickle-cell-disease-associated-moyamoya-syndrome-a-nationwide-cross-sectional-study
#2
JOURNAL ARTICLE
Robert C Osorio, Kunal P Raygor, Lorenzo Rinaldo, Christine K Fox, Neha Bhasin, Adib A Abla, Nalin Gupta
PURPOSE: Sickle-cell disease-associated moyamoya syndrome (SCD-MMS) carries a high risk for recurrent strokes and cerebrovascular morbidity in children. However, few data are available about complications that occur in children hospitalized with SCD-MMS. The purpose of this analysis was to determine the risk factors for in-hospital complications in pediatric SCD-MMS admissions, and thus aid physicians in optimizing future treatment plans. METHODS: A national database of pediatric hospital admissions was examined across the years 2003-2019...
March 26, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38523925/surgical-resection-of-a-pneumothorax-in-an-adult-patient-with-a-history-of-wilson-mikity-syndrome-diagnosed-in-childhood
#3
Ryusei Yoshino, Masaki Nakatsubo, Nanami Ujiie, Masahiro Kitada
Wilson-Mikity syndrome (WMS) is a rare condition characterized by various respiratory and pulmonary abnormalities in neonates and infants. However, the diagnosis is based on the findings of physiological tests, such as respiratory function tests. Reports describing the histopathological features of WMS are limited. The patient was a 22-year-old woman with a history of WMS. She had been on a ventilator for the first three months of life due to pulmonary hypertension after early delivery at 24 weeks of gestation and required oxygen therapy until three years of age...
February 2024: Curēus
https://read.qxmd.com/read/38511245/nesfatin-1-alleviates-hyperoxia-induced-bronchopulmonary-dysplasia-bpd-via-the-nuclear-factor-%C3%AE%C2%BAb-nf-%C3%AE%C2%BAb-p65-signaling-pathway
#4
JOURNAL ARTICLE
Li Zhang, Zhang Zhuo, Lijuan Chen, Jiao Liu, Jiang Huang, Jian Deng, Wei Lu, Xian Jiang
Bronchopulmonary dysplasia (BPD) is a chronic respiratory disease in newborns, which severely influences the health of infants and lacks effective clinical treatment strategies. The pathogenesis of BPD is correlated to enhanced inflammation and activated oxidative stress (OS). The application of antioxidants and anti-inflammatory treatment could be hot spots for BPD treatment. Nesfatin-1, a peptide with a suppressive property against inflammation, was tested herein for its potential therapeutic value in BPD...
April 2024: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38499706/deep-learning-model-for-prediction-of-bronchopulmonary-dysplasia-in-preterm-infants-using-chest-radiographs
#5
JOURNAL ARTICLE
Hao-Yang Chou, Yung-Chieh Lin, Sun-Yuan Hsieh, Hsin-Hung Chou, Cheng-Shih Lai, Bow Wang, Yi-Shan Tsai
Bronchopulmonary dysplasia (BPD) is common in preterm infants and may result in pulmonary vascular disease, compromising lung function. This study aimed to employ artificial intelligence (AI) techniques to help physicians accurately diagnose BPD in preterm infants in a timely and efficient manner. This retrospective study involves two datasets: a lung region segmentation dataset comprising 1491 chest radiographs of infants, and a BPD prediction dataset comprising 1021 chest radiographs of preterm infants. Transfer learning of a pre-trained machine learning model was employed for lung region segmentation and image fusion for BPD prediction to enhance the performance of the AI model...
March 18, 2024: J Imaging Inform Med
https://read.qxmd.com/read/38492414/relationships-between-preterm-medical-factors-and-feeding-behaviors-at-term-equivalent-age
#6
JOURNAL ARTICLE
Carolyn Ibrahim, Molly Grabill, Joan Smith, Roberta Pineda
AIM: To identify relationships between early medical factors and preterm infant feeding behaviors at term-equivalent age. METHODS: Forty-three very preterm infants born ≤32 weeks gestation had standardized feeding assessments using the Neonatal Eating Outcome Assessment at term-equivalent age (36-42 weeks postmenstrual age). Medical factors were collected and analyses were run to determine if associations between different medical factors and feeding performance exist...
February 28, 2024: Early Human Development
https://read.qxmd.com/read/38490918/neurodevelopmental-outcomes-of-extremely-preterm-infants-with-bronchopulmonary-dysplasia-bpd-a-retrospective-cohort-study
#7
REVIEW
Khoa L Nguyen, Dominic A Fitzgerald, Annabel Webb, Barbara Bajuk, Himanshu Popat
OBJECTIVE: To investigate the neurodevelopmental outcomes for preterm infants born < 29 weeks gestation with/without bronchopulmonary dysplasia (BPD). STUDY DESIGN: Preterm infants < 29 weeks' gestation born 2007-2018 in New South Wales and the Australian Capital Territory, Australia, were included. Infants who died < 36 weeks' postmenstrual age and those with major congenital anomalies were excluded. Subjects were assessed at 18-42 months corrected age using the Bayley Scales of Infant Development, 3rd edition...
March 1, 2024: Paediatric Respiratory Reviews
https://read.qxmd.com/read/38488005/disrupted-tgf-%C3%AE-signaling-a-link-between-bronchopulmonary-dysplasia-and-alveolar-type-1-cells
#8
JOURNAL ARTICLE
Rongbo Li
Bronchopulmonary dysplasia (BPD) is a chronic lung disease common in extreme preterm infants and is characterized by alveolar simplification. Current BPD research mainly focuses on alveolar type 2 (AT2) cells, myofibroblasts, and the endothelium. However, a notable gap exists in the involvement of AT1 cells, which constitute a majority of the alveolar surface area. In this issue of the JCI, Callaway and colleagues explored the role of TGF-β signaling in AT1 cells for managing the AT1-to-AT2 transition and its involvement in the integration of mechanical forces with the pulmonary matrisome during development...
March 15, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38484265/lung-function-evaluated-by-structured-light-plethysmography-in-children-after-lung-surgery-a-preliminary-analysis
#9
JOURNAL ARTICLE
Michele Ghezzi, Luisa Abbattista, Anna Dighera, Annalisa De Silvestri, Andrea Farolfi, Gloria Pelizzo, Giovanna Riccipetitoni, Sara Costanzo, Valeria Calcaterra, Gian Vincenzo Zuccotti
Background: Structured light plethysmography (SLP) is a novel light-based method that captures chest wall movements to evaluate tidal breathing. Methods: Thirty-two children who underwent lung surgery were enrolled. Their clinical history was collected along with spirometry and SLP. Results: Median age of surgery was 9 months (interquartile range 4-30). Most frequent diagnosis was congenital pulmonary airway malformation (14/32), then pulmonary sequestration (9/32), tumor (5/32), and bronchogenic cyst (4/32)...
March 2024: Pediatric Allergy, Immunology, and Pulmonology
https://read.qxmd.com/read/38465165/respiratory-syncytial-virus-infection-and-apnea-risk-as-criteria-for-hospitalization-in-full-term-healthy-infants
#10
JOURNAL ARTICLE
Dyana Picache, Diana Gluskin, Asif Noor, Brooke Senken, Theresa Fiorito, Meredith Akerman, Leonard R Krilov, Jill Leavens-Maurer
Introduction Apnea is recognized as a serious and potentially life-threatening complication associated with Respiratory Syncope Virus (RSV). The literature reports a wide range of apnea rates for infants with comorbid factors. Prematurity and young chronological age have been historically associated with the risk of apnea in hospitalized infants. Few studies have specifically examined the risk of apnea in healthy infants presenting to the emergency department. Methods This is a retrospective review of infants diagnosed with RSV using a PCR assay...
February 2024: Curēus
https://read.qxmd.com/read/38457938/infants-with-neonatal-chronic-lung-disease-are-associated-with-delayed-auditory-conduction-in-the-rostral-brainstem-after-term
#11
JOURNAL ARTICLE
Ze Dong Jiang, Cui Wang, James K Jiang, Jin Wang
AIMS: Very Low Birthweight (VLBW) infants with neonatal Chronic Lung Disease (CLD) have been found to have functional impairment of the brainstem auditory pathway at term. This study investigated the functional status of the brainstem auditory pathway in VLBW infants with CLD after term for any abnormality. METHODS: Fifty-two VLBW infants were recruited at 50 weeks of Postconceptional Age: 25 with neonatal CLD and 27 without CLD. None had any other major complications to minimize confounding effects...
March 6, 2024: Clinics
https://read.qxmd.com/read/38454005/association-between-patent-ductus-arteriosus-flow-and-home-oxygen-therapy-in-extremely-preterm-infants
#12
JOURNAL ARTICLE
Jana Termerova, Ales A Kubena, Karel Liska, Viktor Tomek, Richard Plavka
BACKGROUND: Central blood flow measurements include the estimation of right and left ventricular output (RVO, LVO), superior vena cava (SVC) flow, and calculated patent ductus arteriosus (PDA) flow. We aimed to provide an overview of the maturation patterns of these values and the relationship between PDA flow and the need for home oxygen therapy. METHODS: This prospective single-center study was conducted in infants born at <26 weeks of gestation. We performed echocardiographic measurements five times during their life (from the 4th post-natal day to the 36th postmenstrual week)...
March 7, 2024: Pediatric Research
https://read.qxmd.com/read/38452183/outcomes-for-pediatric-oncology-and-hematopoietic-stem-cell-transplantation-patients-who-undergo-tracheostomy-placement-a-pediatric-health-information-system-database-cohort-study-2009-2020
#13
JOURNAL ARTICLE
Sinead L Murphy Salem, Jennifer M Perez, Steven J Staffa, Christine N Duncan, Robert J Graham
OBJECTIVES: To describe the epidemiology, surgical complications, and long-term outcomes after tracheostomy in pediatric oncology and/or hematopoietic stem cell transplantation (HSCT) patients in U.S. Children's Hospitals. DESIGN: Retrospective cohort from the Pediatric Health information System (PHIS) database, 2009-2020. SETTING: The PHIS dataset incorporates data from 48 pediatric hospitals in the Children's Hospital Association. PATIENTS: Patients 0-21 years old with an oncologic diagnosis and/or underwent HSCT, received a tracheostomy, and were discharged from hospital between January 1, 2009, and December 31, 2020...
March 7, 2024: Pediatric Critical Care Medicine
https://read.qxmd.com/read/38432533/mitochondrial-dna-mutations-in-extremely-preterm-infants-with-bronchopulmonary-dysplasia
#14
JOURNAL ARTICLE
Jiyoon Jeong, Yeonmi Lee, Jongsuk Han, Eunju Kang, Deokhoon Kim, Ki-Soo Kim, Ellen Ai-Rhan Kim, Byong Sop Lee, Euiseok Jung
Bronchopulmonary dysplasia (BPD) is a serious chronic lung disease affecting extremely preterm infants. While mitochondrial dysfunction has been investigated in various medical conditions, limited research has explored mitochondrial DNA (mtDNA) gene mutations, specifically in BPD. This study aimed to evaluate mitochondrial mtDNA gene mutations in extremely preterm infants with BPD. In this prospective observational study, we enrolled a cohort of extremely preterm infants diagnosed with BPD. Clinical data were collected to provide comprehensive patient profiles...
March 1, 2024: Gene
https://read.qxmd.com/read/38398389/bridging-the-gap-exploring-bronchopulmonary-dysplasia-through-the-lens-of-biomedical-informatics
#15
REVIEW
Jennifer Kim, Mariela Villarreal, Shreyas Arya, Antonio Hernandez, Alvaro Moreira
Bronchopulmonary dysplasia (BPD), a chronic lung disease predominantly affecting premature infants, poses substantial clinical challenges. This review delves into the promise of biomedical informatics (BMI) in reshaping BPD research and care. We commence by highlighting the escalating prevalence and healthcare impact of BPD, emphasizing the necessity for innovative strategies to comprehend its intricate nature. To this end, we introduce BMI as a potent toolset adept at managing and analyzing extensive, diverse biomedical data...
February 14, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38380928/pulmonary-complications-of-cytomegalovirus-infection-in-neonates-and-infants-a-systematic-review-of-case-reports-and-pooled-analysis
#16
JOURNAL ARTICLE
Leong Tung Ong, Si Wei David Fan
BACKGROUND: Cytomegalovirus (CMV) causes intrauterine infections in 0.67% of neonates, with 12.7% displaying symptoms at birth. CMV can lead to severe multiorgan involvement, and mortality in symptomatic cases is around 30%. Pulmonary complications are rare in infants with CMV. This review assesses pulmonary complications and outcomes in infants with CMV infection. METHODS: A systematic literature search was conducted using PubMed, SCOPUS and Ovid SP to retrieve case reports on pulmonary complications in infants with congenital or perinatal CMV infection...
February 21, 2024: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/38367641/global-disease-burden-of-and-risk-factors-for-acute-lower-respiratory-infections-caused-by-respiratory-syncytial-virus-in-preterm-infants-and-young-children-in-2019-a-systematic-review-and-meta-analysis-of-aggregated-and-individual-participant-data
#17
JOURNAL ARTICLE
Xin Wang, You Li, Ting Shi, Louis J Bont, Helen Y Chu, Heather J Zar, Bhanu Wahi-Singh, Yiming Ma, Bingbing Cong, Emma Sharland, Richard D Riley, Jikui Deng, Josep Figueras-Aloy, Terho Heikkinen, Marcus H Jones, Johannes G Liese, Joško Markić, Asuncion Mejias, Marta C Nunes, Bernhard Resch, Ashish Satav, Kee Thai Yeo, Eric A F Simões, Harish Nair
BACKGROUND: Infants and young children born prematurely are at high risk of severe acute lower respiratory infection (ALRI) caused by respiratory syncytial virus (RSV). In this study, we aimed to assess the global disease burden of and risk factors for RSV-associated ALRI in infants and young children born before 37 weeks of gestation. METHODS: We conducted a systematic review and meta-analysis of aggregated data from studies published between Jan 1, 1995, and Dec 31, 2021, identified from MEDLINE, Embase, and Global Health, and individual participant data shared by the Respiratory Virus Global Epidemiology Network on respiratory infectious diseases...
February 14, 2024: Lancet
https://read.qxmd.com/read/38363393/correlation-between-early-postnatal-body-weight-changes-and-lung-ultrasound-scores-as-predictors-of-bronchopulmonary-dysplasia-in-preterm-infants-a-secondary-analysis-of-a-prospective-study
#18
JOURNAL ARTICLE
Mohab Ghanem, Carlos Zozaya, Jenna Ibrahim, Seungwoo Lee, Nada Mohsen, Nehad Nasef, Adel Mohamed
UNLABELLED: Recent research links early weight changes (EWC) with bronchopulmonary dysplasia (BPD) in preterm neonates, while lung ultrasound score (LUS) has shown promise in predicting BPD. We aimed to explore the correlation between LUS and EWC as markers of extravascular lung edema and to investigate the correlation between LUS and EWC in preterm infants with respiratory distress syndrome regarding future BPD development. This secondary analysis of a prospective study involved infants ≤ 28 weeks gestation...
February 16, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38363050/age-specific-predictors-of-disease-severity-in-children-with-respiratory-syncytial-virus-infection-beyond-infancy-and-through-the-first-5%C3%A2-years-of-age
#19
JOURNAL ARTICLE
Helena Brenes-Chacon, Mariah Eisner, Santiago Acero-Bedoya, Octavio Ramilo, Asuncion Mejias
BACKGROUND: Respiratory syncytial virus (RSV) infection is associated with significant morbidity in infants. Risk factors for severe disease beyond the first 2 years of life have not been fully defined. METHODS: Children <5 years hospitalized with virologically confirmed RSV infection were identified over six respiratory seasons (10/2012-4/2018) and their medical records manually reviewed. Multivariable analyses were performed to define the age-specific (<6, 6-24, and >24-59 months) risk factors associated with oxygen administration, PICU admission, mechanical ventilation, and duration of hospitalization...
February 2024: Pediatric Allergy and Immunology
https://read.qxmd.com/read/38352616/macrophage-polarizations-in-the-placenta-and-lung-are-associated-with-bronchopulmonary-dysplasia
#20
Karen K Mestan, Abhineet Sharma, Sarah Lazar, Sonalisa Pandey, Mana M Parast, Louise C Laurent, Lawrence S Prince, Debashis Sahoo
The intricate interplay between macrophage polarization and placenta vascular dysfunction has garnered increasing attention in the context of placental inflammatory diseases. This study delves into the complex relationship between macrophage polarization within the placenta and its potential impact on the development of vascular dysfunction and inflammatory conditions. The placenta, a crucial organ in fetal development, relies on a finely tuned balance of immune responses for proper functioning. Disruptions in this delicate equilibrium can lead to pathological conditions, including inflammatory diseases affecting the fetus and newborn infant...
January 30, 2024: bioRxiv
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