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https://www.readbyqxmd.com/read/29334522/themes-in-literature-related-to-incidence-risk-and-prevention-of-cancer-in-solid-organ-transplantation-recipients-on-immunosuppressive-therapy
#1
Stefanie L Rashti
BACKGROUND: Solid-organ transplants provide a second chance to thousands of critically ill patients with end-organ failure each year. Immunosuppressants are administered to patients to prevent graft rejection of a transplanted organ, such as a heart, kidney, or liver, while placing the recipient at greater risk for infection and cancer. OBJECTIVE: The literature provides evidence of various cancers that have been found to develop in patients' posttransplantation...
January 12, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29331035/noninvasive-optical-spectroscopy-for-identification-of-non-melanoma-skin-cancer-pilot-study
#2
David J Carpenter, Mirabelle B Sajisevi, Nikita Chapurin, Clifford Scott Brown, Tracy Cheng, Gregory M Palmer, Daniel S Stevenson, Caroline L Rao, Russell P Hall, Charles R Woodard
OBJECTIVE: Optical spectroscopy offers a noninvasive alternative to biopsy as a first-line screening tool for suspicious skin lesions. This study sought to define several optical parameters across malignant and benign tissue types. STUDY DESIGN: Prospective pilot trial utilizing the Zenalux IM1 optical spectroscopy device from April 2016 to February 2017. For each skin lesion, provider pre-biopsy probability of malignancy was compared to histolopathologic diagnosis...
January 13, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29315147/nonmelanoma-skin-cancer-risk-in-patients-with-inflammatory-bowel-disease-undergoing-thiopurine-therapy-a-systematic-review-of-the-literature
#3
Joshua W Hagen, Melissa A Pugliano-Mauro
BACKGROUND: Azathioprine and 6-mercaptopurine (thiopurines) are common adjunct treatments for inflammatory bowel disease (IBD). Although thiopurine therapy in organ transplant recipients is known to increase nonmelanoma skin cancers (NMSCs), dermatologic literature yields less data regarding NMSC risk of thiopurine use in IBD. OBJECTIVE: The aim of this study was to systematically review current literature on NMSC risk in patients with IBD using thiopurine therapy...
January 8, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29311040/prevalence-and-risk-factors-of-actinic-keratosis-in-patients-attending-italian-dermatology-clinics
#4
Maria Concetta Fargnoli, Gianfranco Altomare, Elisa Benati, Francesco Borgia, Paolo Broganelli, Anna Carbone, Sergio Chimenti, Sergio Donato, Giampiero Girolomoni, Giuseppe Micali, Erica Moggio, Aurora Parodi, Stefano Piaserico, Giuseppe Pistone, Concetta Potenza, Mario Puviani, Margherita Raucci, Sabina Vaccari, Stefano Veglio, Andrea Zanca, Ketty Peris
Actinic keratosis (AK) is a common keratinocyte intra-epidermal neoplasia. To assess AK prevalence and potential risk factors in patients attending Italian general dermatology clinics. This retrospective study was conducted on clinical data from consecutive white outpatients aged ≥30 years, attending 24 general dermatology clinics between December 2014 and February 2015. AK prevalence (entire population) and multivariate risk factor analysis (patients with current/previous AK and complete data) are presented...
December 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29301626/temporal-trends-of-de-novo-malignancy-development-after-heart-transplantation
#5
Jong-Chan Youn, Josef Stehlik, Amber R Wilk, Wida Cherikh, In-Cheol Kim, Gyeong-Hun Park, Lars H Lund, Howard J Eisen, Do Young Kim, Sun Ki Lee, Suk-Won Choi, Seongwoo Han, Kyu-Hyung Ryu, Seok-Min Kang, Jon A Kobashigawa
BACKGROUND: Malignancy is a concern in cardiac transplant recipients, but the temporal trends of de novo malignancy development are unknown. OBJECTIVES: The goal of this study was to describe the temporal trends of the incidence, types, and predictors of de novo malignancy in cardiac transplant recipients. METHODS: The authors analyzed the temporal trends of post-transplant incidence, types, and predictors of malignancy using 17,587 primary adult heart-only transplant recipients from the International Society for Heart and Lung Transplantation registry...
January 2, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29249251/-what-s-new-in-oncodermatology
#6
C Lebbé
This 'What's new in oncodermatology?' addresses the developments in 2017 on the epidemiology and management of skin cancers. We observe a constant increase in carcinomas, risk factors for squamous cell carcinoma, especially in transplant recipients where skin cancer mortality is important. Among epidemiological developments in melanoma are increased mortality despite screening, occupational exposure to UV, second melanoma and higher risk after carcinoma. New classifications that should be considered are AJCC8 for melanoma and carcinoma...
December 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29237168/evaluation-of-the-national-swiss-skin-cancer-screening-campaign-2013-do-we-do-the-right-thing
#7
Ralph-Peter Braun, Karina Ulrich, Robert Hunger, Olivier Gaide, Andreas Arnold, Rastine Merat, Reinhard Dummer, Jürg Hafner, Lars E French, Antonio Cozzio
BACKGROUND: Skin cancer prevention and screening programs are performed in many countries. Their benefit is discussed controversially. OBJECTIVE: Our aim is to evaluate the Skin Cancer Screening Program 2013 in Switzerland by following up screenees upon interventions. METHODS: Quality was assessed by personal follow-up via phone/e-mail of every patient that had been screened during this campaign and histological follow-up of all participants with suspicious skin lesions...
December 14, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29234713/promoting-early-detection-of-melanoma-during-the-mammography-experience
#8
A K Rzepecki, N Jain, Y Ali, L Chavez, J Choi, B Schlosser, E Liko-Hazizi, S M Friedewald, J K Robinson
Background: Invasive melanoma, a lethal form of skin cancer, is the seventh most common cancer in women. Factors such as a history of indoor tanning or sunburn and a personal or family history of skin cancer increase a woman's risk of developing a melanoma. Objective: Because the majority of melanomas occur in patients age 40 years or older, which is the age that is recommended for women to begin screening mammograms, the mammogram experience could be used to promote early detection of melanoma by introducing skin self-examinations (SSE) to a population of women who are already invested in preventive health...
December 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/29209060/atr-ftir-spectral-discrimination-between-normal-and-tumorous-mouse-models-of-lymphoma-and-melanoma-from-serum-samples
#9
Hemendra Ghimire, Mahathi Venkataramani, Zhen Bian, Yuan Liu, A G Unil Perera
This study presents, attenuated total reflection Fourier transforms infrared spectroscopy of dried serum samples in an effort to assess biochemical changes induced by non-Hodgkin's lymphoma and subcutaneous melanoma. An EL4 mouse model of non-Hodgkin lymphoma and a B16 mouse model of subcutaneous melanoma are used to extract a snapshot of tumor-associated alteration in the serum. The study of both cancer-bearing mouse models in wild types and their corresponding control types, emphasizes the diagnostic potential of this approach as a screening technique for non-Hodgkin lymphoma and melanoma skin cancer...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29194095/is-nonmetastatic-cutaneous-melanoma-predictable-through-genomic-biomarkers
#10
Mattia Branca, Samuel Orso, Roberto C Molinari, Haotian Xu, Stéphane Guerrier, Yuming Zhang, Nabil Mili
Cutaneous melanoma is a highly aggressive skin cancer whose treatment and prognosis are critically affected by the presence of metastasis. In this study, we address the following issue: which gene transcripts and what kind of interactions between them can allow to predict nonmetastatic from metastatic melanomas with a high level of accuracy? We carry out a meta-analysis on the first gene expression set of the Leeds melanoma cohort, as made available online on 11 May 2016 through the ArrayExpress platform with MicroArray Gene Expression number 4725...
February 2018: Melanoma Research
https://www.readbyqxmd.com/read/29187412/protocol-for-the-melatools-skin-self-monitoring-trial-a-phase-ii-randomised-controlled-trial-of-an-intervention-for-primary-care-patients-at-higher-risk-of-melanoma
#11
Katie Mills, Jon Emery, Rebecca Lantaff, Michael Radford, Merel Pannebakker, Per Hall, Nigel Burrows, Kate Williams, Catherine L Saunders, Peter Murchie, Fiona M Walter
INTRODUCTION: Melanoma is the fifth most common cancer in the UK. Incidence rates have quadrupled over the last 30 years and continue to rise, especially among younger people. As routine screening of the general population is not currently recommended in the UK, a focus on secondary prevention through early detection and prompt treatment in individuals at increased risk of melanoma could make an important contribution to improve melanoma outcomes. This paper describes the protocol for a phase II, multisite, randomised controlled trial, in the primary care setting, for patients at increased risk of melanoma...
November 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/29186890/investigation-of-health-effects-according-to-the-exposure-of-low-concentration-arsenic-contaminated-ground-water
#12
Young-Seoub Hong, Byeong-Jin Ye, Yu-Mi Kim, Byoung-Gwon Kim, Gyeong-Hui Kang, Jeong-Jin Kim, Ki-Hoon Song, Young-Hun Kim, Jeong-Wook Seo
Recent epidemiological studies have reported adverse health effects, including skin cancer, due to low concentrations of arsenic via drinking water. We conducted a study to assess whether low arsenic contaminated ground water affected health of the residents who consumed it. For precise biomonitoring results, the inorganic (trivalent arsenite (As III) and pentavalent arsenate (As V)) and organic forms (monomethylarsonate (MMA) and dimethylarsinate (DMA)) of arsenic were separately quantified by combining high-performance liquid chromatography and inductively coupled plasma mass spectroscopy from urine samples...
November 27, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29182649/men-s-perspectives-of-prostate-cancer-screening-a-systematic-review-of-qualitative-studies
#13
Laura J James, Germaine Wong, Jonathan C Craig, Camilla S Hanson, Angela Ju, Kirsten Howard, Tim Usherwood, Howard Lau, Allison Tong
BACKGROUND: Prostate cancer is the most commonly diagnosed non-skin cancer in men. Screening for prostate cancer is widely accepted; however concerns regarding the harms outweighing the benefits of screening exist. Although patient's play a pivotal role in the decision making process, men may not be aware of the controversies regarding prostate cancer screening. Therefore we aimed to describe men's attitudes, beliefs and experiences of prostate cancer screening. METHODS: Systematic review and thematic synthesis of qualitative studies on men's perspectives of prostate cancer screening...
2017: PloS One
https://www.readbyqxmd.com/read/29180093/estimating-the-cost-of-skin-cancer-detection-by-dermatology-providers-in-a-large-healthcare-system
#14
Martha Matsumoto, Aaron Secrest, Alyce Anderson, Melissa I Saul, Jonhan Ho, John M Kirkwood, Laura K Ferris
BACKGROUND: Data on the cost and efficiency of skin cancer detection through total body skin examination (TBSE) are scarce. OBJECTIVE: To determine the number needed to screen (NNS) and biopsy (NNB) and cost per skin cancer diagnosed in a large dermatology practice in patients undergoing TBSE. METHODS: Retrospective observational study. RESULTS: From 2011 - 2015, 20,270 patients underwent 33,647 visits for TBSE; 9956 lesion biopsies were performed yielding 2,763 skin cancers, including 155 melanomas...
November 24, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29176098/incidence-of-non-melanoma-skin-cancer-in-the-uninsured
#15
Ashley Sturgeon, David Allen Pate, Ravi Patel, Katherine Snodgrass, Michelle Tarbox, Fiona Prabhu, Phillip Watkins
Non-melanoma skin cancer (NMSC) is a common reason for outpatient primary care visits. Uninsured patients may be at a higher risk for NMSC due to lack of access to health care and a possible increased risk of sun exposure due to insecure housing. The true incidence of NMSC in this population is unknown. In order to determine the population's incidence of NMSC we performed a retrospective chart review on all patients (n = 656) seen at the Lubbock Impact Free Clinic from July 1, 2014 through July 30, 2015. This highlighted an increased incidence of NMSC in our uninsured population (1...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/29171018/personal-history-of-non-melanoma-skin-cancer-diagnosis-and-death-from-melanoma-in-women
#16
Steven T Chen, Xin Li, Jiali Han
Melanoma incidence is increasing. We evaluated risk of melanoma death after diagnosis of non-melanoma skin cancer (NMSC). We followed 77,288 female American nurses from the Nurses' Health Study from 1986 to 2012. We used Cox proportional hazards models to determine the hazard ratio (HR) of lethal and non-lethal melanoma diagnosis and melanoma death, according to personal NMSC history. Among melanoma cases, we examined the HR of melanoma death and the odds ratio (OR) of melanoma with a Breslow thickness ≥0...
November 24, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29169765/whole-exome-sequencing-allows-the-identification-of-two-novel-groups-of-xeroderma-pigmentosum-in-tunisia-xp-d-and-xp-e-impact-on-molecular-diagnosis
#17
Mariem Ben Rekaya, Chokri Naouali, Olfa Messaoud, Meriem Jones, Yosra Bouyacoub, Majdi Nagara, Tommaso Pippucci, Haifa Jmel, Mariem Chargui, Manel Jerbi, Mohamed Alibi, Hamza Dallali, Anu Bashamboo, Kenneth McElreavey, Giovanni Romeo, Abdelhamid Barakat, Mohamed Zghal, Houda Yacoub-Youssef, Sonia Abdelhak
BACKGROUND: Skin cancers (SC) are complex diseases that develop from complex combinations of genetic and environmental risk factors. One of the most severe and rare genetic diseases predisposing to SC is the Xeroderma pigmentosum (XP) syndrome. OBJECTIVES: First, to identify the genetic etiology of XP and to better classify affected patients. Second, to provide early molecular diagnosis for pre-symptomatic patient and finally to offer genetic counseling for related individuals...
November 2, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29169295/observed-and-expected-mortality-in-the-german-skin-cancer-screening-pilot-project-screen
#18
Nora Eisemann, Annika Waldmann, Bernd Holleczek, Alexander Katalinic
Objective The main purpose of skin cancer screening is melanoma mortality reduction. Before the implementation of nationwide German skin cancer screening, the pilot project SCREEN was conducted in Schleswig-Holstein in 2003-2004. We aimed to determine whether the pilot project had achieved a mortality reduction. Methods Using an incidence-based approach (patients with both melanoma diagnosis and death in 2003-2008), we compared the observed melanoma mortality of the SCREEN cohort to the melanoma mortality expected without screening in the general population of Saarland...
January 1, 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/29113361/a-case-control-study-on-association-of-nucleotide-excision-repair-polymorphisms-and-its-interaction-with-environment-factors-with-the-susceptibility-to-non-melanoma-skin-cancer
#19
Yan-Ling Li, Feng Wei, Yu-Ping Li, Li-Hua Zhang, Yan-Zhi Bai
Aims: To investigate the association of several single nucleotide polymorphisms (SNPs) within nucleotide excision repair (NER) gene and additional gene- gene and gene- smoking interaction with non-melanoma skin cancer (NMSC) risk in a Chinese population. Methods: A total of 1322 participants (939 males, 383 females) were selected, including 660 NMSC patients and 662 control participants. Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among SNPs and smoking...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29104226/updates-on-the-management-of-non-melanoma-skin-cancer-nmsc
#20
REVIEW
Artur Fahradyan, Anna C Howell, Erik M Wolfswinkel, Michaela Tsuha, Parthiv Sheth, Alex K Wong
Non-melanoma skin cancers (NMSCs) are the most common malignancy worldwide, of which 99% are basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) of skin. NMSCs are generally considered a curable diseases, yet they currently pose an increasing global healthcare problem due to rising incidence. This has led to a shift in emphasis on prevention of NMSCs with development of various skin cancer prevention programs worldwide. This article aims to summarize the most recent changes and advances made in NMSC management with a focus on prevention, screening, diagnosis, and staging...
November 1, 2017: Healthcare (Basel, Switzerland)
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