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https://www.readbyqxmd.com/read/29053921/integrated-kidney-exosome-analysis-ikea-for-the-detection-of-kidney-transplant-rejection
#1
Jongmin Park, Hsing-Ying Lin, Jean Pierre Assaker, Sangmoo Jeong, Chen-Han Huang, Ahmed Kurdi, Kyungheon Lee, Kyle Fraser, Changwook Min, Siawosh Eskandari, Sujit Routray, Bakhos A Tannous, Reza Abdi, Leonardo Riella, Anil Chandraker, Cesar M Castro, Ralph Weissleder, Hakho Lee, Jamil R Azzi
Kidney transplant patients require life-long surveillance to detect allograft rejection. Repeated biopsy, albeit the clinical gold standard, is an invasive procedure with the risk of complications and comparatively high cost. Conversely, serum creatinine or urinary proteins are non-invasive alternatives, but are late markers with low specificity. We here report a new urine-based platform to detect kidney transplant rejection. Termed iKEA (integrated kidney exosome analysis), the approach detects extracellular vesicles (EVs) released by immune cells into urine; we reasoned that T cells, attacking kidney allografts, would shed EVs, which in turn can be used as surrogate marker for inflammation...
October 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/29053401/are-we-prepared-for-emerging-flaviviruses-in-europe-challenges-for-vaccination
#2
Patricia Kaaijk, Willem Luytjes
Tick-borne encephalitis and West Nile fever are endemic flavivirus diseases in Europe. Climate change, virus evolution, and social factors may increase the risk of these flavivirus infections and may lead to the emergence of other flaviviruses in Europe that are endemic in (sub)tropical regions of the world. Control of the spread of flaviviruses is very difficult considering the cycling of flaviviruses between arthropod vectors and animal reservoir hosts. The increasing threat of flavivirus infections emphasizes the necessity of a sustainable vector surveillance system, an active animal health surveillance system and an adequate human surveillance system for early detection of flavivirus infections...
October 20, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29053239/school-sealant-programs-a-cost-effective-way-to-prevent-childhood-caries
#3
(no author information available yet)
No abstract text is available yet for this article.
February 23, 2017: Journal of the California Dental Association
https://www.readbyqxmd.com/read/29053216/-suspicious-salivary-gland-fna-risk-of-malignancy-and-interinstitutional-variability
#4
Zahra Maleki, James Adam Miller, Seyedeh Elham Arab, Guido Fadda, Ping Bo, Olga Wise, Esther Diana Rossi, Nirag Jhala, Chandra Ashish, Syed Z Ali, He Wang
BACKGROUND: Fine-needle aspiration (FNA) cytology is well accepted as a safe, reliable, minimally invasive, and cost-effective method for the diagnosis of salivary gland lesions. Salivary gland neoplasms are often difficult to diagnose because of morphologic heterogeneity and a variety of epithelial metaplastic changes. Hence, a number of salivary gland FNA specimens yield indeterminate results. For indeterminate FNA specimens, the suspicious-for-malignancy (SFM) category is used when a specific neoplasm falls short in quantity or quality for the criteria for malignancy...
October 20, 2017: Cancer
https://www.readbyqxmd.com/read/29053157/current-applications-of-multiparameter-flow-cytometry-in-plasma-cell-disorders
#5
REVIEW
T Jelinek, R Bezdekova, M Zatopkova, L Burgos, M Simicek, T Sevcikova, B Paiva, R Hajek
Multiparameter flow cytometry (MFC) has become standard in the management of patients with plasma cell (PC) dyscrasias, and could be considered mandatory in specific areas of routine clinical practice. It plays a significant role during the differential diagnostic work-up because of its fast and conclusive readout of PC clonality, and simultaneously provides prognostic information in most monoclonal gammopathies. Recent advances in the treatment and outcomes of multiple myeloma led to the implementation of new response criteria, including minimal residual disease (MRD) status as one of the most relevant clinical endpoints with the potential to act as surrogate for survival...
October 20, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/29052923/hexagonal-sphericon-hematite-with-high-performance-for-water-oxidation
#6
Taiwo Odedairo, Xuecheng Yan, Xiangdong Yao, Kostya Ken Ostrikov, Zhonghua Zhu
A cost-effective hexagonal sphericon hematite with predominant (110) facets for the oxygen evolution reaction (OER) is demonstrated. Sequential incorporation of near-atomic uniformly distributed Ce species and Ni nanoparticles into selected sites of the hematite induces a complex synergistic integration phenomenon that enhances the overall catalytic OER performance. This cheap hexagonal sphericon hematite (Fe ≈ 98%) only needs a small overpotential (η) of 0.34 V to reach 10 mA cm(-2) , superior to commercial IrO2 and more expensive Co-, Ni-, and Li-based electrocatalysts...
October 20, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29052888/cost-effectiveness-of-hla-b-15-02-screening-in-malaysia
#7
C Plumpton, D Hughes
No abstract text is available yet for this article.
October 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29052529/evaluating-a-multi-component-community-based-program-to-improve-adherence-and-retention-in-care-among-adolescents-living-with-hiv-in-zimbabwe-study-protocol-for-a-cluster-randomized-controlled-trial
#8
Webster Mavhu, Nicola Willis, Juliet Mufuka, Collin Mangenah, Kudzanayi Mvududu, Sarah Bernays, Walter Mangezi, Tsitsi Apollo, Ricardo Araya, Helen A Weiss, Frances M Cowan
BACKGROUND: World Health Organization (WHO) adolescent HIV-testing and treatment guidelines recommend community-based interventions to support antiretroviral therapy (ART) adherence and retention in care, while acknowledging that the evidence to support this recommendation is weak. This cluster randomized controlled trial aims to evaluate the effectiveness and cost-effectiveness of a psychosocial, community-based intervention on HIV-related and psychosocial outcomes. METHODS/DESIGN: We are conducting the trial in two districts...
October 20, 2017: Trials
https://www.readbyqxmd.com/read/29052503/intensive-follow-up-for-women-with-breast-cancer-review-of-clinical-economic-and-patient-s-preference-domains-through-evidence-to-decision-framework
#9
Alessandra Lafranconi, Liisa Pylkkänen, Silvia Deandrea, Anke Bramesfeld, Donata Lerda, Luciana Neamțiu, Zuleika Saz-Parkinson, Margarita Posso, David Rigau, Ivan Sola, Pablo Alonso-Coello, Maria José Martinez-Zapata
BACKGROUND: Women treated for breast cancer are followed-up for monitoring of treatment effectiveness and for detecting recurrences at an early stage. The type of follow-up received may affect women's reassurance and impact on their quality of life. Anxiety and depression among women with breast cancer has been described, but little is known about how the intensity of the follow-up can affect women's psychological status. This study was undertaken to evaluate the effects of intensive vs...
October 19, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29052164/the-role-of-condition-specific-preference-based-measures-in-health-technology-assessment
#10
REVIEW
Donna Rowen, John Brazier, Roberta Ara, Ismail Azzabi Zouraq
A condition-specific preference-based measure (CSPBM) is a measure of health-related quality of life (HRQOL) that is specific to a certain condition or disease and that can be used to obtain the quality adjustment weight of the quality-adjusted life-year (QALY) for use in economic models. This article provides an overview of the role and the development of CSPBMs, and presents a description of existing CSPBMs in the literature. The article also provides an overview of the psychometric properties of CSPBMs in comparison with generic preference-based measures (generic PBMs), and considers the advantages and disadvantages of CSPBMs in comparison with generic PBMs...
October 19, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29052158/estimating-health-state-utility-values-for-comorbidities
#11
REVIEW
Roberta Ara, John Brazier
A comorbidity is defined as the presence of at least one additional health condition co-occurring with a primary health condition. Decision analytic models in healthcare depict the typical clinical pathway of patients in general clinical practice and frequently include health states defined to represent comorbidities such as sequelae or adverse events. Health state utility values (HSUVs) are often not available for these and analysts generally estimate them. This article provides a summary of the methodological literature on estimating methods frequently used together with worked examples...
October 19, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29052157/a-review-of-generic-preference-based-measures-for-use-in-cost-effectiveness-models
#12
REVIEW
John Brazier, Roberta Ara, Donna Rowen, Helene Chevrou-Severac
Generic preference-based measures (GPBMs) of health are used to obtain the quality adjustment weight required to calculate the quality-adjusted life year in health economic models. GPBMs have been developed to use across different interventions and medical conditions and typically consist of a self-complete patient questionnaire, a health state classification system, and preference weights for all states defined by the classification system. Of the six main GPBMs, the three most frequently used are the Health Utilities Index version 3, the EuroQol 5 dimensions (3 and 5 levels), and the Short Form 6 dimensions...
October 19, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29052154/heath-state-utility-values-for-cost-effectiveness-models
#13
EDITORIAL
Jonathan Karnon
No abstract text is available yet for this article.
October 19, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29052047/an-alternative-approach-for-estimating-above-ground-biomass-using-resourcesat-2-satellite-data-and-artificial-neural-network-in-bundelkhand-region-of-india
#14
Dibyendu Deb, J P Singh, Shovik Deb, Debajit Datta, Arunava Ghosh, R S Chaurasia
Determination of above ground biomass (AGB) of any forest is a longstanding scientific endeavor, which helps to estimate net primary productivity, carbon stock and other biophysical parameters of that forest. With advancement of geospatial technology in last few decades, AGB estimation now can be done using space-borne and airborne remotely sensed data. It is a well-established, time saving and cost effective technique with high precision and is frequently applied by the scientific community. It involves development of allometric equations based on correlations of ground-based forest biomass measurements with vegetation indices derived from remotely sensed data...
October 20, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29052044/the-cost-effectiveness-of-exercise-based-cardiac-rehabilitation-a-systematic-review-of-the-characteristics-and-methodological-quality-of-published-literature
#15
REVIEW
Katherine Edwards, Natasha Jones, Julia Newton, Charlie Foster, Andrew Judge, Kate Jackson, Nigel K Arden, Rafael Pinedo-Villanueva
AIM: This descriptive review aimed to assess the characteristics and methodological quality of economic evaluations of cardiac rehabilitation (CR) programs according to updated economic guidelines for healthcare interventions. Recommendations will be made to inform future research addressing the impact of a physical exercise component on cost-effectiveness. METHODS: Electronic databases were searched for economic evaluations of exercise-based CR programs published in English between 2000 and 2014...
October 19, 2017: Health Economics Review
https://www.readbyqxmd.com/read/29051831/randomized-controlled-trial-of-an-e-learning-designed-behavioral-intervention-for-increasing-physical-activity-behavior-in-multiple-sclerosis
#16
Robert W Motl, Elizabeth A Hubbard, Rachel E Bollaert, Brynn C Adamson, Dominique Kinnett-Hopkins, Julia M Balto, Sarah K Sommer, Lara A Pilutti, Edward McAuley
BACKGROUND: Internet-delivered, behavioral interventions represent a cost-effective, broadly disseminable approach for teaching persons with multiple sclerosis (MS) the theory-based skills, techniques, and strategies for changing physical activity. OBJECTIVES: This pilot, randomized controlled trial examined the efficacy of a newly developed Internet website based on e-learning approaches that delivered a theory-based behavior intervention for increasing physical activity and improving symptoms, walking impairment, and neurological disability...
October 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/29051816/eptifibatide-is-associated-with-significant-cost-savings-and-similar-clinical-outcomes-to-abciximab-when-used-during-primary-percutaneous-coronary-intervention-for-st-elevation-myocardial-infarction-an-observational-cohort-study-of-3863-patients
#17
K S Rathod, S Antoniou, P Avari, N Ding, P Wright, C Knight, A K Jain, A Mathur, E J Smith, R Weerackody, A Wragg, D A Jones
INTRODUCTION: Glycoprotein IIb/IIIa inhibitors are recommended by guidelines in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. There are few studies directly comparing these agents. The aim of this study was to assess whether eptifibatide is a safe and cost-effective alternative to abciximab in the treatment of primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. METHODS: This was an observational cohort study of 3863 patients who received a GPIIb/IIIa inhibitor whilst undergoing primary percutaneous coronary intervention from 2007 to 2014...
January 2017: JRSM Cardiovascular Disease
https://www.readbyqxmd.com/read/29051339/most-cost-effective-treatments-for-lung-disease-identified
#18
Anne Gulland
No abstract text is available yet for this article.
October 19, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29051143/health-care-costs-associated-with-aki
#19
David Collister, Neesh Pannu, Feng Ye, Matthew James, Brenda Hemmelgarn, Betty Chui, Braden Manns, Scott Klarenbach
BACKGROUND AND OBJECTIVES: An understanding of the health care resource use associated with AKI is needed to frame the investment and cost-effectiveness of strategies to prevent AKI and promote kidney recovery. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We assembled population-based cohort of adults hospitalized in Alberta between November of 2002 and March of 2009 without ESRD or an eGFR<15 ml/min per 1.73 m(2). Outpatient serum creatinine measurements 6 months preceding admission defined baseline kidney function, and serum creatinine during the first 14 days of hospitalization defined Acute Kidney Injury Network stage; kidney recovery defined as serum creatinine within 25% of baseline and independence from dialysis was assessed at 90 days after AKI...
October 19, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29051136/using-google-glass-in-nonsurgical-medical-settings-systematic-review
#20
Bryn Dougherty, Sherif M Badawy
BACKGROUND: Wearable technologies provide users hands-free access to computer functions and are becoming increasingly popular on both the consumer market and in various industries. The medical industry has pioneered research and implementation of head-mounted wearable devices, such as Google Glass. Most of this research has focused on surgical interventions; however, other medical fields have begun to explore the potential of this technology to support both patients and clinicians. OBJECTIVE: Our aim was to systematically evaluate the feasibility, usability, and acceptability of using Google Glass in nonsurgical medical settings and to determine the benefits, limitations, and future directions of its application...
October 19, 2017: JMIR MHealth and UHealth
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