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"Cost-effectiveness"

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https://www.readbyqxmd.com/read/29677560/effective-discovery-of-rare-variants-by-pooled-target-capture-sequencing-a-comparative-analysis-with-individually-indexed-target-capture-sequencing
#1
Seungjin Ryu, Jeehae Han, Trina M Norden-Krichmar, Nicholas J Schork, Yousin Suh
Identification of all genetic variants associated with complex traits is one of the most important goals in modern human genetics. Genome-wide association studies (GWAS) have been successfully applied to identify common variants, which thus far explain only small portion of heritability. Interests in rare variants have been increasingly growing as an answer for this missing heritability. While next-generation sequencing allows detection of rare variants, its cost is still prohibitively high to sequence a large number of human DNA samples required for rare variant association studies...
March 30, 2018: Mutation Research
https://www.readbyqxmd.com/read/29677242/value-of-primary-data-in-cost-effectiveness-analyses
#2
Dana M Blumberg
No abstract text is available yet for this article.
April 12, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29677145/polymer-based-electrospun-nanofibers-for-biomedical-applications
#3
REVIEW
Abdullah M Al-Enizi, Moustafa M Zagho, Ahmed A Elzatahry
Electrospinning has been considered a promising and novel procedure to fabricate polymer nanofibers due to its simplicity, cost effectiveness, and high production rate, making this technique highly relevant for both industry and academia. It is used to fabricate non-woven fibers with unique characteristics such as high permeability, stability, porosity, surface area to volume ratio, ease of functionalization, and excellent mechanical performance. Nanofibers can be synthesized and tailored to suit a wide range of applications including energy, biotechnology, healthcare, and environmental engineering...
April 20, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29677081/changes-in-pediatric-heart-transplant-hospitalization-costs-over-time
#4
Justin Godown, Cary Thurm, Matt Hall, Jonathan H Soslow, Brian Feingold, Bret A Mettler, Andrew H Smith, David W Bearl, Debra A Dodd
BACKGROUND: Despite significant changes in the past decade for children undergoing heart-transplantation, including the evolution of mechanical circulatory support and increasing patient complexity, costs and resource utilization have not been reassessed. We sought to utilize a novel linkage of clinical-registry and administrative data to examine changes in hospitalization costs over time in this population. METHODS: We identified all pediatric heart transplant recipients in a unique linked PHIS/SRTR dataset (2002-2016)...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29676891/the-pyroelectric-effect-enables-simple-and-rapid-evaluation-of-biofilm-formation
#5
Oriella Gennari, Valentina Marchesano, Romina Rega, Laura Mecozzi, Filomena Nazzaro, Florinda Fratianni, Raffaele Coppola, Luca Masucci, Emanuela Mazzon, Alessia Bramanti, Pietro Ferraro, Simonetta Grilli
Biofilms are detrimental to human life and industrial processes due to potential infections, contaminations and deterioration. Therefore, the evaluation of microbial capability to form biofilms is of fundamental importance for assessing how different environmental factors may affect their vitality. Nowadays, the approaches used for biofilm evaluation are still poor in reliability and rapidity and often provide contradictory results. Here we present what we call Biofilm Electrostatic Test (BET) as a simple, rapid and high reproducible tool for evaluating in vitro the ability of bacteria to form biofilms through the electrostatic interaction with a pyro-electrified carrier...
April 20, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29676824/the-safety-effectiveness-and-cost-effectiveness-of-cytisine-in-achieving-six-month-continuous-smoking-abstinence-in-tuberculosis-patients-protocol-for-a-double-blind-placebo-controlled-randomised-trial
#6
Omara Dogar, Deepa Barua, Melanie Boeckmann, Helen Elsey, Razia Fatima, Rhian Gabe, Rumana Huque, Ada Keding, Amina Khan, Daniel Kotz, Eva Kralikova, James N Newell, Iveta Nohavova, Steve Parrott, Anne Readshaw, Lottie Renwick, Aziz Sheikh, Kamran Siddiqi
BACKGROUND AND AIMS: Tuberculosis (TB) patients who quit smoking have much better disease outcomes than those who continue to smoke. Behavioural support combined with pharmacotherapy is the most effective strategy in helping people to quit, in general populations. However, there is no evidence for the effectiveness of this strategy in TB patients who smoke. We will assess the safety, effectiveness and cost-effectiveness of cytisine - a low-cost plant-derived nicotine substitute - for smoking cessation in TB patients compared with placebo, over and above brief behavioural support...
April 20, 2018: Addiction
https://www.readbyqxmd.com/read/29676787/turning-high-risk-individuals-an-economic-evaluation-of-repositioning-frequency-in-long-term-care
#7
Petros Pechlivanoglou, Mike Paulden, Ba' Pham, Josephine Wong, Susan D Horn, Murray Krahn
Recent evidence suggests that less frequent repositioning of long-term care residents at moderate to high risk of developing pressure ulcers (PrUs) is noninferior to current repositioning standards in preventing PrUs, but the long-term health and economic consequences of less frequent repositioning have not been adequately estimated. Our objective was to estimate the cost-effectiveness of different repositioning strategies (2-, 3-, 4-hour intervals). We conducted a cost-utility analysis using a lifetime horizon based on data from a randomized clinical trial and the literature...
April 20, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29676707/-ultrasound-guided-surgery-for-breast-cancer
#8
J H Volders, N M H Krekel, M H Haloua, S Meijer, M P van den Tol
Recent literature shows that perioperative ultrasound guidance of surgery for palpable and nonpalpable breast carcinoma results in improved surgical effectiveness. Ultrasound-guided surgery can easily lead to significant improvement of the number of radical resections and can decrease the need for additional surgery or extra radiotherapy. Ultrasound-guided surgery also contributes to a reduction in the amount of excessive breast tissue removal, which means the final cosmetic result is better. Ultrasound-guided surgery is cost-effective and easy to learn...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29676641/toxic-and-genomic-influences-of-inhaled-nanomaterials-as-a-basis-for-predicting-adverse-outcome
#9
Penny Nymark, Pekka Kohonen, Vesa Hongisto, Roland C Grafström
An immense variety of different types of engineered nanomaterials are currently being developed and increasingly applied to consumer products. Importantly, engineered nanomaterials may pose unexplored adverse health effects because of their small size. Particularly in occupational settings, the dustiness of certain engineered nanomaterials involves risk of inhalation and influences on lung function. These facts call for quick and cost-effective safety testing practices, such as that obtained through multiparametric high-throughput screening using cultured human lung cells...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676613/workshop-report-using-social-media-and-smartphone-applications-in-practical-lessons-to-enhance-student-learning-in-b%C3%A3%C2%BAzios-brazil-august-6-8-2017
#10
Camilo Lellis-Santos, Patricia A Halpin
Cost-effective student engagement poses a challenge for instructors, especially those who may not be familiar with new technologies and mobile devices. In this workshop, participants, experienced and discussed two ways of using smartphones in physiology classes: to engage in an online learning environment for discussions, and to make physiological measurements. Participants signed up for individual Twitter accounts and learned how to tweet, retweet, message, use a URL shortener, and use hashtags. They then went on to locate articles on an assigned topic from the Twitter accounts of credible science sources ( American Journal of Physiology, The Scientist, CDC...
June 1, 2018: Advances in Physiology Education
https://www.readbyqxmd.com/read/29676510/economic-evaluations-of-system-based-obesity-interventions-the-case-for-a-new-approach
#11
REVIEW
D Sonntag, R Sweeney, D Litaker, M Moodie
System-based interventions are of increasing interest as they seek to modify environments (e.g. socio-cultural system, transport system or policy system) that promote development of conditions such as obesity and its related risk factors. In our commentary, we draw attention to features of the system-based approach that may explain the relative absence of economic evaluations of the cost-effectiveness of these interventions, needed to guide decision-making on which to deploy. We present and discuss potentially applicable methods and alternative approaches based on our experiences in two major system-based interventions currently underway (in Melbourne, Australia and Gaggenau, Germany) that begin to fill this gap...
April 20, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29676194/dose-duration-and-cost-opportunities-to-improve-use-of-long-term-oral-antibiotics-for-people-with-rosacea
#12
Joanne S Rill, Hadar Lev-Tov, Guodong Liu, Joslyn S Kirby
BACKGROUND: Systemic antibiotics are often used to treat rosacea and tetracyclines are the most common antibiotic prescribed; however, there is ambiguity among clinical guideline suggestions. Importantly, there is an increasing call to all clinicians to curtail antibiotic use. OBJECTIVE: Investigate the utilization and cost of long-term oral antibiotic use for the treatment of rosacea, including ocular rosacea. METHODS: This was a retrospective cohort study of MarketScan® Commercial Claims and Encounters database, from January 1, 2005 through December 31, 2014...
April 20, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29676055/the-development-of-funding-recommendations-for-health-technologies-at-the-state-level-a-south-australian-case-study
#13
Robyn Lambert, Drew Carter, Naomi Burgess, Hossein Haji Ali Afzali
OBJECTIVES: State governments often face capped budgets that can restrict expenditure on health technologies and their evaluation, yet many technologies are introduced to practice through state-funded institutions such as hospitals, rather than through national evaluation mechanisms. This research aimed to identify the criteria, evidence, and standards used by South Australian committee members to recommend funding for high-cost health technologies. METHODS: We undertook 8 semi-structured interviews and 2 meeting observations with members of state-wide committees that have a mandate to consider the safety, effectiveness, and cost-effectiveness of high-cost health technologies...
April 20, 2018: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/29675992/genetic-counselors-as-social-and-behavioral-scientists-in-the-era-of-precision-medicine
#14
Barbara B Biesecker
In the era of precision medicine, translating genomics into clinical care will involve answering key questions in social and behavioral research. The scope of this research addresses assessing how clients perceive and use genomic information, and how effectively genetic counseling is meeting clients' needs. Outcomes are central to enhancing practice effectiveness, improving patient outcomes, and informing cost effective services to address workforce challenges. While genetic counseling is generally thought of as a clinical practice, genetic counselors contribute to research in several ways...
March 2018: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/29675332/50-hz-volumetric-functional-imaging-with-continuously-adjustable-depth-of-focus
#15
Rongwen Lu, Masashi Tanimoto, Minoru Koyama, Na Ji
Understanding how neural circuits control behavior requires monitoring a large population of neurons with high spatial resolution and volume rate. Here we report an axicon-based Bessel beam module with continuously adjustable depth of focus (CADoF), that turns frame rate into volume rate by extending the excitation focus in the axial direction while maintaining high lateral resolutions. Cost-effective and compact, this CADoF Bessel module can be easily integrated into existing two-photon fluorescence microscopes...
April 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29675317/high-pulse-energy-supercontinuum-laser-for-high-resolution-spectroscopic-photoacoustic-imaging-of-lipids-in-the-1650-1850-nm-region
#16
Manoj Kumar Dasa, Christos Markos, Michael Maria, Christian R Petersen, Peter M Moselund, Ole Bang
We propose a cost-effective high-pulse energy supercontinuum (SC) source based on a telecom range diode laser-based amplifier and a few meters of standard single-mode optical fiber, with a pulse energy density as high as ~25 nJ/nm in the 1650-1850 nm regime (factor >3 times higher than any SC source ever used in this wavelength range). We demonstrate how such an SC source combined with a tunable filter allows high-resolution spectroscopic photoacoustic imaging and the spectroscopy of lipids in the first overtone transition band of C-H bonds (1650-1850 nm)...
April 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29675221/multiple-advanced-logic-gates-made-of-dna-ag-nanocluster-and-the-application-for-intelligent-detection-of-pathogenic-bacterial-genes
#17
Xiaodong Lin, Yaqing Liu, Jiankang Deng, Yanlong Lyu, Pengcheng Qian, Yunfei Li, Shuo Wang
The integration of multiple DNA logic gates on a universal platform to implement advance logic functions is a critical challenge for DNA computing. Herein, a straightforward and powerful strategy in which a guanine-rich DNA sequence lighting up a silver nanocluster and fluorophore was developed to construct a library of logic gates on a simple DNA-templated silver nanoclusters (DNA-AgNCs) platform. This library included basic logic gates, YES, AND, OR, INHIBIT, and XOR, which were further integrated into complex logic circuits to implement diverse advanced arithmetic/non-arithmetic functions including half-adder, half-subtractor, multiplexer, and demultiplexer...
February 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29674986/comparing-feedback-types-in-multimedia-learning-of-speech-by-young-children-with-common-speech-sound-disorders-research-protocol-for-a-pretest-posttest-independent-measures-control-trial
#18
Wendy Doubé, Paul Carding, Kieran Flanagan, Jordy Kaufman, Hannah Armitage
Children with speech sound disorders benefit from feedback about the accuracy of sounds they make. Home practice can reinforce feedback received from speech pathologists. Games in mobile device applications could encourage home practice, but those currently available are of limited value because they are unlikely to elaborate "Correct"/"Incorrect" feedback with information that can assist in improving the accuracy of the sound. This protocol proposes a "Wizard of Oz" experiment that aims to provide evidence for the provision of effective multimedia feedback for speech sound development...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29674731/functionalized-magnetic-nanoparticles-synthesis-characterization-catalytic-application-and-assessment-of-toxicity
#19
Mariana Neamtu, Claudia Nadejde, Vasile-Dan Hodoroaba, Rudolf J Schneider, Liliana Verestiuc, Ulrich Panne
Cost-effective water cleaning approaches using improved treatment technologies, for instance based on catalytic processes with high activity catalysts, are urgently needed. The aim of our study was to synthesize efficient Fenton-like photo-catalysts for rapid degradation of persistent organic micropollutants in aqueous medium. Iron-based nanomaterials were chemically synthesized through simple procedures by immobilization of either iron(II) oxalate (FeO) or iron(III) citrate (FeC) on magnetite (M) nanoparticles stabilized with polyethylene glycol (PEG)...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29674588/capillarity-induced-folds-fuel-extreme-shape-changes-in-thin-wicked-membranes
#20
Paul Grandgeorge, Natacha Krins, Aurélie Hourlier-Fargette, Christel Laberty-Robert, Sébastien Neukirch, Arnaud Antkowiak
Soft deformable materials are needed for applications such as stretchable electronics, smart textiles, or soft biomedical devices. However, the design of a durable, cost-effective, or biologically compatible version of such a material remains challenging. Living animal cells routinely cope with extreme deformations by unfolding preformed membrane reservoirs available in the form of microvilli or membrane folds. We synthetically mimicked this behavior by creating nanofibrous liquid-infused tissues that spontaneously form similar reservoirs through capillarity-induced folding...
April 20, 2018: Science
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