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"Cost-effectiveness"

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https://www.readbyqxmd.com/read/28346659/is-universal-hla-b-15-02-screening-a-cost-effective-option-in-an-ethnically-diverse-population-a-case-study-of-malaysia
#1
H Y Chong, Z Mohamed, L L Tan, D B C Wu, F H Shabaruddin, M Dahlui, Y D Apalasamy, S R Snyder, M S Williams, J Hao, L H Cavallari, N Chaiyakunapruk
BACKGROUND: Strong association was documented between human leukocyte antigen (HLA)-B*15:02 and carbamazepine-induced severe cutaneous adverse reactions (SCARs) in Asians. Beyond Asia, the HLA testing is potentially valuable in many countries with increasingly diverse communities of Asian ancestry, to facilitate an early recognition of patient susceptibility to SCARs. OBJECTIVE: To determine the cost-effectiveness of universal HLA-B*15:02 screening in preventing carbamazepine-induced Stevens-Johnson syndrome/ toxic epidermal necrolysis in an ethnically-diverse Malaysian population...
March 27, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28346653/how-successful-is-the-fitting-of-digital-hearing-aids-implications-for-the-allocation-of-resources-within-national-health-systems
#2
Petros V Vlastarakos, Alastair I Cameron, Thomas P Nikolopoulos
We conducted a retrospective study to determine the success rate of initial fittings in digital hearing aid (DHA) users. We also addressed the implications of national health systems' continuing to provide access to these devices. We identified 1,597 consecutively presenting adults who had undergone a first fitting or a new fitting (i.e., an upgrade from an analogue hearing aid in the first or second ear) of a behind-the-ear DHA during the previous year. We further sought to identify all nominal reprogram appointments that had taken place within 6 months after the first or new fitting; we found 460 such appointments (28...
March 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28346623/family-medicine-maternity-care-call-to-action-moving-toward-national-standards-for-training-and-competency-assessment
#3
Susanna R Magee, W Suzanne Eidson-Ton, Larry Leeman, Michael Tuggy, Thomas O Kim, Melissa Nothnagle, Joseph Breuner, Mark Loafman
Maternity care is an integral part of family medicine, and the quality and cost-effectiveness of maternity care provided by family physicians is well documented. Considering the population health perspective, increasing the number of family physicians competent to provide maternity care is imperative, as is working to overcome the barriers discouraging maternity care practice. A standard that clearly defines maternity care competency and a systematic set of tools to assess competency levels could help overcome these barriers...
March 2017: Family Medicine
https://www.readbyqxmd.com/read/28346260/effectiveness-analysis-of-a-part-time-rapid-response-system-during-operation-versus-nonoperation
#4
Youlim Kim, Dong Seon Lee, Hyunju Min, Yun Young Choi, Eun Young Lee, Inae Song, Jong Sun Park, Young-Jae Cho, You Hwan Jo, Ho Il Yoon, Jae Ho Lee, Choon-Taek Lee, Sang Hwan Do, Yeon Joo Lee
OBJECTIVES: To evaluate the effect of a part-time rapid response system on the occurrence rate of cardiopulmonary arrest by comparing the times of rapid response system operation versus nonoperation. DESIGN: Retrospective cohort study. SETTING: A 1,360-bed tertiary care hospital. PATIENTS: Adult patients admitted to the general ward were screened. Data were collected over 36 months from rapid response system implementation (October 2012 to September 2015) and more than 45 months before rapid response system implementation (January 2009 to September 2012)...
March 24, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28346253/a-retrospective-case-matched-cost-comparison-of-surgical-treatment-of-melanoma-and-nonmelanoma-skin-cancer-in-the-outpatient-versus-operating-room-setting
#5
Ryan P Johnson, Niraj Butala, Murad Alam, Naomi Lawrence
BACKGROUND: To date, no study has used authentic billing data in a case-control matched fashion to examine the cost of treating skin cancer in different settings. OBJECTIVE: To compare the cost of surgical treatment of skin cancer in the outpatient versus operating room setting using matched cases based on patient and skin cancer characteristics. METHODS: ICD-9 diagnosis codes for skin cancers were used to find patients who had a malignant excision current procedural terminology code in the operating room setting during 2010 to 2014...
March 23, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28346096/a-novel-multiparametric-drug-scoring-method-for-high-throughput-screening-of-3d-multicellular-tumor-spheroids-using-the-celigo-image-cytometer
#6
Scott Cribbes, Sarah Kessel, Scott McMenemy, Jean Qiu, Leo Li-Ying Chan
Three-dimensional (3D) tumor models have been increasingly used to investigate and characterize cancer drug compounds. The ability to perform high-throughput screening of 3D multicellular tumor spheroids (MCTS) can highly improve the efficiency and cost-effectiveness of discovering potential cancer drug candidates. Previously, the Celigo Image Cytometer has demonstrated a novel method for high-throughput screening of 3D multicellular tumor spheroids. In this work, we employed the Celigo Image Cytometer to examine the effects of 14 cancer drug compounds on 3D MCTS of the glioblastoma cell line U87MG in 384-well plates...
January 1, 2017: SLAS Discov
https://www.readbyqxmd.com/read/28345903/molecular-imprinting-on-inorganic-nanozymes-for-hundred-fold-enzyme-specificity
#7
Zijie Zhang, Xiaohan Zhang, Biwu Liu, Juewen Liu
Enzyme-mimicking nanomaterials (nanozymes) are more cost-effective and robust than protein enzymes, but they lack specificity. Herein, molecularly imprinted polymers were grown on Fe3O4 nanozymes with peroxidase-like activity to create substrate binding pockets. Electron microscopy confirmed a shell of nanogel. By imprinting with an adsorbed substrate, moderate specificity was achieved with neutral monomers. Further introducing charged monomers led to nearly 100-fold specificity for the imprinted substrate over the non-imprinted compared to that of bare Fe3O4...
March 27, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28345872/intrinsically-stretchable-and-conductive-textile-by-a-scalable-process-for-elastic-wearable-electronics
#8
Chunya Wang, Mingchao Zhang, Kailun Xia, Xueqin Gong, Huimin Wang, Zhe Yin, Baolu Guan, Yingying Zhang
The prosperous development of stretchable electronics poses great demand in stretchable conductive materials which could maintain their electrical conductivity under tensile strain. Previously reported strategies to obtain stretchable conductors usually involve complex structure-fabricating processes or utilization of high-cost nanomaterials. It remains a great challenge to produce stretchable and conductive materials via a scalable and cost-effective process. A large-scalable pyrolysis strategy is developed for the fabrication of intrinsically stretchable and conductive textile utilizing low-cost and mass-produced weft-knitted textiles as raw materials...
March 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28345870/ultra-fast-separation-and-analysis-of-monoclonal-antibody-aggregates-using-membrane-chromatography
#9
Pedram Madadkar, Umatheny Umatheva, Geoff Hale, Yves Durocher, Raja Ghosh
We discuss a method for rapid and cost-effective analysis of monoclonal antibody (mAb) aggregates. Hydrophobic interaction membrane chromatography, which was previously shown to be highly suitable for such separation and analysis, was used in a recently developed format referred to as laterally-fed membrane chromatography (or LFMC). A stack of rectangular polyvinylidene fluoride (or PVDF) membranes having 0.22 µm pores housed within a modified analytical-scale LFMC device was used for analyzing aggregate types and content in different monoclonal antibody samples...
March 27, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28345771/effect-of-intra-cellular-trafficking-on-flow-cytometric-measurement-of-neutrophil-s-oxidative-status-in-iron-deficient-pregnant-females
#10
Soha R Youssef, Sherif F Hendawy, Noha H Boshnak, Mariana S Sedhom
BACKGROUND: Iron deficiency and iron deficiency anemia are prevalent among pregnant women particularly in developing countries. This study aimed to evaluate the iron status among Egyptian pregnant women and its impact on their neutrophil's count and antimicrobial functions. METHOD: Ninety pregnant females underwent complete blood count, iron profile, flow cytometric studies for neutrophil myeloperoxidase expression & oxidative burst using dihydrorhodamine 123 (DHR) after phorbol-12-myristate-13-acetate (PMA) stimulation as well as neutrophil phagocytic and lytic indices...
March 27, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28345749/the-use-of-social-media-for-campus-safety
#11
Brittany Haupt, Naim Kapucu, Jeffrey Morgan
As public safety communication evolved, each disaster or emergency presented unique challenges for emergency managers and others response to disasters. Yet, a foundational focus is the timely dissemination of accurate information to keep communities informed and able to prepare, mitigate, respond, and recover. For the campus community, the increase in bomb threats, active shooter incidents, and geographic-based natural disasters call for the discovery of reliable and cost-effective solutions for emergency information management...
January 2017: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/28345710/desktop-nmr-for-structure-elucidation-and-identification-of-strychnine-adulteration
#12
Kawarpal Singh, Bernhard Blümich
Elucidating the structure of complex molecules is difficult at low magnetic fields due to the overlap of different peak multiplets and second-order coupling effects. This is even more challenging for rigid molecules with small chemical shift differences and with prochiral centers. Since low-field NMR spectroscopy is sometimes presumed as restricted to the analysis of only small and simple molecules, this paper aims at countering this misconception: it demonstrates the use of low-field NMR spectroscopy in chemical forensics for identifying strychnine and its counterions by exploring the chemical shift as a signature in different 1D (1)H and (13)C experiments...
March 27, 2017: Analyst
https://www.readbyqxmd.com/read/28345511/-complete-removable-denture-retained-by-symphyseal-implant
#13
A Abdelkoui, N Lakhssassi, N Merzouk, S Berrada
INTRODUCTION: Edentulous patients often hope for stable and retentive prostheses. In very unfavorable anatomophysiological circumstances, the implant-retained removable full denture is a simple and reliable option that considerably optimizes the prosthetic balance. We present the case of one of those patients taken in charge in our department. OBSERVATION: A full edentulous 82 years old male patient was referred for a prosthetic rehabilitation. He presented with a negative mandibular crest and a very tonic peri-prosthetic musculature in the anterior region...
February 22, 2017: J Stomatol Oral Maxillofac Surg
https://www.readbyqxmd.com/read/28345481/cost-effectiveness-analysis-of-implementing-an-antimicrobial-stewardship-programme-in-critical-care-units
#14
Jesus Ruiz-Ramos, Juan Frasquet, Eva Romá, Jose Luis Poveda-Andres, Miguel Salavert-Leti, Alvaro Catellanos, Paula Ramirez
AIMS: To evaluate the cost-effectiveness of antimicrobial stewardship (AS) programme implementation focused on critical care units based on assumptions for the Spanish setting. MATERIAL AND METHODS: A decision model comparing costs and outcomes of sepsis, community-acquired pneumonia, and nosocomial infections (including catheter-related bacteremia, urinary tract infection, and ventilator-associated pneumonia) in critical care units with or without an AS was designed...
March 26, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28345220/boosting-the-performance-of-the-nickel-anode-in-the-oxygen-evolution-reaction-by-simple-electrochemical-activation
#15
Tatsuya Shinagawa, Marcus Tze-Kiat Ng, Kazuhiro Takanabe
The development of cost-effective and active water-splitting electrocatalysts that work at mild pH is an essential step towards the realization of sustainable energy and material circulation in our society. Its success requires a drastic improvement in the kinetics of the anodic half-reaction of the oxygen evolution reaction (OER), which determines the overall system efficiency to a large extent. A simple electrochemical protocol has been developed to activate Ni electrodes, by which a stable NiOOH phase was formed, which could weakly bind to alkali-metal cations...
March 27, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28344822/quantitative-analysis-of-lipids-a-higher-throughput-lc-ms-ms-based-method-and-its-comparison-to-elisa
#16
Adarsh S Gandhi, David Budac, Tanzilya Khayrullina, Roland Staal, Gamini Chandrasena
AIM: Lipids such as prostaglandins, leukotrienes and thromboxanes are released as a result of an inflammatory episode in pain (central and peripheral). METHODOLOGY & RESULTS: To measure these lipids as potential mechanistic biomarkers in neuropathic pain models, we developed a higher-throughput LC-MS/MS-based method with simultaneous detection of PGE2, PGD2, PGF2α, LTB4, TXB2 and 2-arachidonoyl glycerol in brain and spinal cord tissues. We also demonstrate that the LC-MS/MS method was more sensitive and specific in differentiating PGE2 levels in CNS tissues compared with ELISA...
March 2017: Future Science OA
https://www.readbyqxmd.com/read/28344636/development-of-an-efficient-glucosinolate-extraction-method
#17
T Doheny-Adams, K Redeker, V Kittipol, I Bancroft, S E Hartley
BACKGROUND: Glucosinolates, anionic sulfur rich secondary metabolites, have been extensively studied because of their occurrence in the agriculturally important brassicaceae and their impact on human and animal health. There is also increasing interest in the biofumigant properties of toxic glucosinolate hydrolysis products as a method to control agricultural pests. Evaluating biofumigation potential requires rapid and accurate quantification of glucosinolates, but current commonly used methods of extraction prior to analysis involve a number of time consuming and hazardous steps; this study aimed to develop an improved method for glucosinolate extraction...
2017: Plant Methods
https://www.readbyqxmd.com/read/28344600/staged-reconstruction-brachytherapy-has-lower-overall-cost-in-recurrent-soft-tissue-sarcoma
#18
Arash O Naghavi, Ricardo J Gonzalez, Jacob G Scott, Youngchul Kim, Yazan A Abuodeh, Tobin J Strom, Michelle Echevarria, John E Mullinax, Kamran A Ahmed, Louis B Harrison, Daniel C Fernandez
PURPOSE: Adjuvant brachytherapy (AB) with immediate (IR) and staged reconstruction (SR) are distinct treatment modalities available for patients with recurrent soft tissue sarcoma (STS). Although SR may offer local control and toxicity benefit, it requires additional upfront procedures, and there is no evidence that it improves overall survival. With the importance of value-based care, our goal is to identify which technique is more cost effective. MATERIAL AND METHODS: A retrospective review of 22 patients with recurrent extremity STS treated with resection followed by AB alone...
February 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28344591/studying-the-genetics-of-resistance-to-cyhv-3-disease-using-introgression-from-feral-to-cultured-common-carp-strains
#19
Roni Tadmor-Levi, Efrat Asoulin, Gideon Hulata, Lior David
Sustainability and further development of aquaculture production are constantly challenged by outbreaks of fish diseases, which are difficult to prevent or control. Developing fish strains that are genetically resistant to a disease is a cost-effective and a sustainable solution to address this challenge. To do so, heritable genetic variation in disease resistance should be identified and combined together with other desirable production traits. Aquaculture of common carp has suffered substantial losses from the infectious disease caused by the cyprinid herpes virus type 3 (CyHV-3) virus and the global spread of outbreaks indicates that many cultured strains are susceptible...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28344528/surgical-approach-and-anesthetic-modality-for-carpal-tunnel-release-a-nationwide-database-study-with-health-care-cost-implications
#20
Brock D Foster, Lakshmanan Sivasundaram, Nathanael Heckmann, Jeremiah R Cohen, William C Pannell, Jeffrey C Wang, Alidad Ghiassi
Background: Carpal tunnel release (CTR) is commonly performed for carpal tunnel syndrome once conservative treatment has failed. Operative technique and anesthetic modality vary by surgeon preference and patient factors. However, CTR practices and anesthetic trends have, to date, not been described on a nationwide scale in the United States. Methods: The PearlDiver Patient Records Database was used to search Current Procedural Terminology codes for elective CTR from 2007 to 2011. Anesthetic modality (eg, general and regional anesthesia vs local anesthesia) and surgical approach (eg, endoscopic vs open) were recorded for this patient population...
March 2017: Hand: Official Journal of the American Association for Hand Surgery
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