Kathryn McCauley, Juliana Durack, Ricardo Valladares, Douglas W Fadrosh, Din L Lin, Agustin Calatroni, Petra K LeBeau, Hoang T Tran, Kei E Fujimura, Brandon LaMere, Geil Merana, Kole Lynch, Robyn T Cohen, Jacqueline Pongracic, Gurjit K Khurana Hershey, Carolyn M Kercsmar, Michelle Gill, Andrew H Liu, Haejin Kim, Meyer Kattan, Stephen J Teach, Alkis Togias, Homer A Boushey, James E Gern, Daniel J Jackson, Susan V Lynch
BACKGROUND: In infants, distinct nasopharyngeal bacterial microbiotas differentially associate with the incidence and severity of acute respiratory tract infection and childhood asthma development. OBJECTIVE: We hypothesized that distinct nasal airway microbiota structures also exist in children with asthma and relate to clinical outcomes. METHODS: Nasal secretion samples (n = 3122) collected after randomization during the fall season from children with asthma (6-17 years, n = 413) enrolled in a trial of omalizumab (anti-IgE) underwent 16S rRNA profiling...
November 2019: Journal of Allergy and Clinical Immunology