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corynebacterium pediatric

Zeynep Gökçe Gayretli Aydın, Gönül Tanır, Selin Nar Ötgün, Meral Turan, Türkan Aydın Teke, Ayşe Kaman, Selçuk Kılıç
Although a significant decrease has been reported in the incidence of diphteria in many regions of the world following the routine diphtheria immunization programs, the emergence of new cases indicated that toxigenic strains are still circulating in the community. Diphtheria vaccine does not provide protection against asymptomatic carriage and colonization of non-toxigenic Corynebacterium diphtheriae. It is a known fact that invasive infections may arise from non-toxigenic C.diphtheriae strains that the non-toxigenic strains can become toxigenic strains leading to diphteria...
July 2017: Mikrobiyoloji Bülteni
Ta-Chiang Liu, Bhaskar Gurram, Megan Baldridge, Richard Head, Vy Lam, Chengwei Luo, Yumei Cao, Pippa Simpson, Michael Hayward, Mary Holtz, Joshua Noe, Diana Lerner, Jose Cabrera, Vincent Biank, Michael Stephens, Curtis Huttenhower, Dermot McGovern, Ramnik Xavier, Thaddeus Stappenbeck, Nita Salzman
BACKGROUND: To identify and develop novel targeted therapies for complex diseases such as Crohn's disease (CD), functional subtypes rooted in pathogenesis must be defined. One candidate method to subtype CD is to define the small intestinal Paneth cell phenotypes based on the intracellular distribution of antimicrobial proteins. We have previously shown that in CD patients, Paneth cell phenotype correlates with the patients' genotype, distinct gene expression signature, presence of granuloma (pathologic hallmark), and time to recurrence after surgery...
March 2016: Inflammatory Bowel Diseases
Lindsey Bomar, Silvio D Brugger, Brian H Yost, Sean S Davies, Katherine P Lemon
UNLABELLED: Bacterial interspecies interactions play clinically important roles in shaping microbial community composition. We observed that Corynebacterium spp. are overrepresented in children free of Streptococcus pneumoniae (pneumococcus), a common pediatric nasal colonizer and an important infectious agent. Corynebacterium accolens, a benign lipid-requiring species, inhibits pneumococcal growth during in vitro cocultivation on medium supplemented with human skin surface triacylglycerols (TAGs) that are likely present in the nostrils...
January 5, 2016: MBio
Alain J Benitez, Christian Hoffmann, Amanda B Muir, Kara K Dods, Jonathan M Spergel, Frederic D Bushman, Mei-Lun Wang
BACKGROUND: Eosinophilic esophagitis (EoE) is an allergic disorder characterized by eosinophil-predominant esophageal inflammation, which can be ameliorated by food antigen restriction. Though recent studies suggest that changes in dietary composition may alter the distal gut microbiome, little is currently known about the impact of a restricted diet upon microbial communities of the oral and esophageal microenvironments in the context of EoE. We hypothesize that the oral and esophageal microbiomes of EoE patients are distinct from non-EoE controls, that these differences correspond to changes in esophageal inflammation, and that targeted therapeutic dietary intervention may influence community structure...
2015: Microbiome
Seyed Mohsen Dehghani, Mohammad Ali Shakiba, Maziyar Ziaeyan, Mohammad Hadi Imanieh, Mahmood Haghighat, Majid Sedaghat, Abdolvahab Alborzi, Seyed Ali Malek-Hosseini
BACKGROUND/AIMS: Generally, prevention of infections by vaccination is the least invasive and most cost-effective approach to reduce the incidence of infections and the morbidity and mortality in transplant recipients. Genetic diversity and different liver disease among patients contributes to variability in immune responses to vaccines and pathogens. The aim of this study was to evaluate immunity status to different vaccinated organisms in pediatric liver-transplant candidates. MATERIALS AND METHODS: The vaccination charts of 90 patients who were referred to Organ Transplant Center of Shiraz University of Medical Sciences were reviewed and compare with National Immunization Program recommendation, after that 10 mL blood was drawn from these patients for serologic studies by ELISA...
December 2014: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
B Ghebremedhin, W Koenig
The aim of this study was to determine the prevalence of bacterial carriage in the anterior nares of two different patient cohorts, aged 5-15 years. By use of a sensitive enrichment broth, Gram-positive and -negative bacteria were cultured from the two cohorts of each 100 patients at the Referral Clinic in Eritrea and at a German University Hospital. In the German cohort, 27% of the patients were positive either for Gram-negative (n=5) or -positive bacteria, including Staphylococcus aureus (n=8; MRSA (n=2)), Staphylococcus epidermidis (n=12), Corynebacterium spp...
September 2012: European Journal of Microbiology & Immunology
Yu Kawasaki, Kousaku Matsubara, Haruko Ishihara, Hiroyuki Nigami, Aya Iwata, Koji Kawaguchi, Takashi Fukaya, Yoshiaki Kawamura, Ken Kikuchi
We here present a 7-year-old girl with ventricular septum defect and ventriculoatrial communication, who developed infective endocarditis (IE) due to Corynebacterium propinquum in the tricuspid valve. The patient was admitted because of an 8-day history of fever. Transthoracic echocardiogram showed non-pedunculated vegetation on the septal leaflet of the tricuspid valve. Gram-positive coryneform bacteria grew from three consecutive sets of blood cultures taken on admission. C. propinquum was confirmed by 3 microbiological approaches; (i) biochemical testing using API Coryne panels, (ii) a sequence-based method using the 16S rRNA gene and partial rpoB sequencing, and (iii) matrix-assisted laser desorption ionization-time of flight mass spectrometry...
May 2014: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Alvin L Young, King S Leung, Nicole Tsim, Mamie Hui, Vishal Jhanji
PURPOSE: To report the risk factors and microbiological profile of pediatric microbial keratitis cases in a tertiary care hospital in Hong Kong. DESIGN: Retrospective study. METHODS: Case records of patients <18 years old with microbial keratitis were reviewed over a period of 10 years, between January 2001 and December 2010. Risk factors, microbiological profile, and treatment outcomes were analyzed. RESULTS: Overall, 18 patients (13 female, 5 male) with unilateral microbial keratitis were included...
November 2013: American Journal of Ophthalmology
Sreeharsha V Nandyala, Richard M Schwend
STUDY DESIGN: Retrospective case control study. OBJECTIVE: To determine prevalence and risk factors for intraoperative bacterial contamination in posterior spinal deformity surgery. SUMMARY OF BACKGROUND DATA: The prevalence of deep surgical site infection in pediatric spinal deformity surgery varies from 1% to 14%. Little evidence exists about the incidence and role of intraoperative bacterial contamination. METHODS: A total of 114 cases of pediatric posterior instrumented deformity surgery were retrospectively identified...
April 15, 2013: Spine
Sandeep Kumar Kanwal, Dinesh Yadav, Viswas Chhapola, Virendra Kumar
A retrospective study was done on 48 consecutive patients with clinical diagnosis of post-diphtheritic neuropathy admitted to the paediatric intensive care unit of tertiary care hospital in North India between January 2008 and December 2010 to study the clinical profile of post-diphtheritic neuropathy in children. The case records were reviewed and information regarding personal details, clinical features, recovery parameters and outcome was recorded using a predesigned proforma. Median age was 4.25 years. All cases were unimmunized...
October 2012: Tropical Doctor
Ahmet Balıkcı, Aynur E Topkaya, Zeliha Belaş
Arcanobacterium haemolyticum, previously known as Corynebacterium haemolyticum, is a facultative anaerobic, gram-positive bacillus with negative catalase and positive CAMP inhibition test results. It may be the causative agent of about 0.5-3% of acute bacterial pharyngitis especially in children and young adults. Since growth of A.haemolyticum is usually inhibited by flora members and since it slowly develops hemolysis in sheep blood agar and its colony morphology resembles beta-hemolytic streptococci, it is frequently overlooked in the evaluation of throat cultures...
July 2011: Mikrobiyoloji Bülteni
Suzan Okten, Ahmet Asan
This study was performed between January 2004 and December 2004 in 13 stations in the Pediatric Unit of Edirne Government Hospital in order to determine the outdoor and indoor airborne microfungal and bacterial contents. The results of air samplings revealed that 1,376 microfungal and 2,429 bacterial colonies in total were isolated. The isolated microfungal specimens were identified and 65 species from 16 genera were determined. Among these, the most frequent genus was Cladosporium with 462 colonies (33.58%) followed by Alternaria with 310 (22...
March 2012: Environmental Monitoring and Assessment
Sang Hyuk Park, Hyoeun Shim, Nam Seop Yoon, Mi Na Kim
BACKGROUND: Continuous monitoring systems have allowed determination of the time-to-positivity (TTP). We evaluated the clinical relevance of TTP in the BACTEC9240 system (Becton-Dickinson, USA). METHODS: A total of 2,354 vials of positive blood cultures were evaluated over 2 months. TTP was monitored from each of BACTEC Plus Aerobic/F (BD) or Pediatric Plus/F and Lytic Anaerobic/F bottles, and the differential time-to-positivity (DTP) for blood samples drawn simultaneously via catheter and a peripheral site was determined...
June 2010: Korean Journal of Laboratory Medicine
Ener Cagri Dinleyici, Zeynel Abidin Yargic, Ozcan Bor, Abdurrahman Kiremitci, Gul Durmaz
Corynebacterium jeikeium has been recognized as an important cause of infection, particularly among neutropenic patients who have central venous catheter (CVC). Routine use of tigecycline in children is not yet approved. Here in we present a child with relapsed-refractory lymphoblastic leukemia who was successfully treated with tigecyline due to multi-drug-resistant C. jeikeium sepsis without removal of CVC. Our case highlights the use of tigecycline where there are no alternatives. Further studies regarding the efficacy and safety of tigecycline in pediatric patients are needed...
August 2010: Pediatric Blood & Cancer
I Fontana, M Bertocchi, A M Rossi, G Gasloli, G Santori, C Ferro, V Patti, A Rossini, U Valente
The incidence of Corynebacterium urealyticum infection in kidney recipients is low. Its common clinical manifestation is encrusted cystitis or encrusted pyelitis. Herein, we report an unusual case of a 19-year-old kidney recipient with necrotizing pyelitis due to C urealyticum in the absence of mucosal encrustation or calculi. The patient was readmitted 30 days posttransplantation to remove a stent. Cystoscopy demonstrated a normal vesical wall without encrustation. The stent was removed without problems. Culture yielded negative findings...
May 2010: Transplantation Proceedings
David Schnell, Constance Beyler, Fanny Lanternier, Hugues Lucron, David Lebeaux, Emmanuelle Bille, Damien Bonnet, Olivier Lortholary, Xavier Nassif, Jean-Ralph Zahar, Fanny Bajolle
We report a pediatric case of negative blood culture pulmonary valve endocarditis caused by a nontoxinogenic Corynebacterium diphtheriae biotype gravis and review the literature on this disease.
September 2010: Pediatric Infectious Disease Journal
R Brodzik, S Spitsin, N Pogrebnyak, K Bandurska, C Portocarrero, K Andryszak, H Koprowski, M Golovkin
The current diphtheria-tetanus-pertussis (DTP) pediatric vaccine is produced from the corresponding pathogenic bacteria Corynebacterium diphtheriae, Clostridium tetani and Bordetella pertussis; five injected doses of DTaP (acellular) vaccine are required for every child in the standard US vaccination schedule. Because the vaccine is derived from native live sources, adverse effects are possible and production is complex and costly. To address issues of safety, ease of renewability and expense, we used recombinant technology in an effort to develop a subunit DPT vaccine derived in non-pathogenic plant expression systems...
June 8, 2009: Vaccine
Heather Rigby, Conrad V Fernandez, Joanne Langley, Tim Mailman, Bruce Crooks, Ann Higgins
BACKGROUND: Hematopoietic stem cell transplant (HSCT) recipients are at a high risk for late bloodstream infection (BSI). Controversy exists regarding the benefit of surveillance blood cultures in this immunosuppressed population. Despite the common use of this practice, the practical value is not well established in non-neutropenic children following HSCT. METHODS: At the IWK Health Centre (Halifax, Nova Scotia), weekly surveillance blood cultures from central lines are drawn from children following HSCT until the line is removed...
July 2007: Canadian Journal of Infectious Diseases & Medical Microbiology
Elisabeth E Adderson, Jan W Boudreaux, Randall T Hayden
BACKGROUND: Invasive infections caused by coryneform bacteria are uncommon but have been reported with increasing frequency in recent decades, especially in immunocompromised persons. Because pediatric experience is limited, we examined the epidemiology and clinical characteristics of these infections in children undergoing cancer therapy. METHODS: Using strict case definitions, 17 coryneform bacterial infections were identified in 16 children during a 13-year period; there were 12 episodes of bacteremia and 5 skin or soft tissue infections...
February 2008: Pediatric Infectious Disease Journal
Jaime Belmares, Stephanie Detterline, Janet B Pak, Jorge P Parada
BACKGROUND: Corynebacterium species are recognized as uncommon agents of endocarditis, but little is known regarding species-specific risk factors and outcomes in Corynebacterium endocarditis. METHODS: Case report and Medline search of English language journals for cases of Corynebacterium endocarditis. Inclusion criteria required that cases be identified as endocarditis, having persistent Corynebacterium bacteremia, murmurs described by the authors as identifying the affected valve, or vegetations found by echocardiography or in surgical or autopsy specimens...
2007: BMC Infectious Diseases
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