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https://www.readbyqxmd.com/read/28633638/evaluating-the-impact-of-prescription-drug-monitoring-program-implementation-a-scoping-review
#1
Erin P Finley, Ashley Garcia, Kristen Rosen, Don McGeary, Mary Jo Pugh, Jennifer Sharpe Potter
BACKGROUND: Prescription drug monitoring programs (PDMPs) have been implemented in 49 out of 50 states in an effort to reduce opioid-related misuse, abuse, and mortality, yet the literature evaluating the impact of PDMP implementation remains limited. We conducted a scoping review to: (1) describe available evidence regarding impact of PDMPs in the U.S.; and (2) propose a conceptual model to inform future PDMP implementation and evaluation efforts. METHODS: Scoping systematic review following Arksey and O'Malley's (2005) methodology...
June 20, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28611022/fda-pulls-opioid-from-market-over-misuse-concerns
#2
Owen Dyer
No abstract text is available yet for this article.
June 13, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28609748/neighborhood-characteristics-and-prescription-drug-misuse-among-adolescents-the-importance-of-social-disorganization-and-social-capital
#3
Jason A Ford, Sarah Ann Sacra, Alexis Yohros
BACKGROUND: Prior research on prescription drug misuse has focused on identifying individual risk factors. While a few studies examine differences in misuse based on geographic residence, there is a lack of research that examines the relevance of neighbourhood characteristics. METHODS: The current research used data from the 2000 National Household Survey on Drug Abuse, a sample of respondents that was generalizable to the non-institutionalised population of the United States...
June 10, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28605278/prescription-opioid-misuse-and-public-health-approach-in-australia
#4
Tom Kovitwanichkanont, Carolyn Day
The number of opioid prescriptions has increased significantly over the last few years due to multiple factors, such as physicians' heightened attention to pain management, greater prevalence of chronic pain due to the aging population, and the availability of sustained-release opioid preparations. Correspondingly, this has been associated with a rise in considerable harm due to opioid misuse, which is recognized as a national health priority in Australia. This article outlines the major public health approaches that have been introduced in Australia to address this issue...
June 12, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28602044/the-dynamic-interaction-between-pain-and-opioid-misuse
#5
REVIEW
Adrianne R Wilson-Poe, Jose A Moron
In 2014, drug overdose surpassed automobile accidents as the number one cause of accidental death for the first time in US history. The overdose epidemic is largely driven by opioids, and genuine prescription opioid analgesics play the biggest role in this phenomenon. Despite advancements in abuse deterrent formulations, prescription drug monitoring programs, and clinical assessments for the detection of abuse potential, drug overdoses continue to escalate. The CDC has recently issued new guidelines for opioid prescription, yet even these recommendations have their shortcomings...
June 11, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28591976/do-drug-monitoring-programs-reduce-the-misuse-of-opioids
#6
(no author information available yet)
No abstract text is available yet for this article.
2017: National Bureau of Economic Research Bulletin on Aging and Health
https://www.readbyqxmd.com/read/28590391/misuse-of-novel-synthetic-opioids-a-deadly-new-trend
#7
Matthew P Prekupec, Peter A Mansky, Michael H Baumann
: Novel synthetic opioids (NSOs) include various analogs of fentanyl and newly emerging non-fentanyl compounds. Together with illicitly manufactured fentanyl (IMF), these drugs have caused a recent spike in overdose deaths, whereas deaths from prescription opioids have stabilized. NSOs are used as stand-alone products, as adulterants in heroin, or as constituents of counterfeit prescription medications. During 2015 alone, there were 9580 deaths from synthetic opioids other than methadone. Most of these fatalities were associated with IMF rather than diverted pharmaceutical fentanyl...
June 5, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28580748/opioid-addiction-and-misuse-in-adult-and-adolescent-patients-with-cancer
#8
Ross Pinkerton, Janet R Hardy
In the context of a therapeutic opioid epidemic, particularly in the USA, where increasingly stringent screening for 'at risk' individuals and close monitoring of opioid prescription and use is strongly recommended, the issue of misuse within the cancer population must be addressed. Most patients with advanced cancer will have pain requiring opioid therapy at some stage during their disease course. In the majority, this will provide good pain relief with no short- or longer-term adverse sequelae. A subset will present with substance misuse issues that will influence management and prescribing practice...
June 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28578864/exposure-to-fentanyl-contaminated-heroin-and-overdose-risk-among-illicit-opioid-users-in-rhode-island-a-mixed-methods-study
#9
Jennifer J Carroll, Brandon D L Marshall, Josiah D Rich, Traci C Green
BACKGROUND: Illicit fentanyl use has become wide spread in the US, causing high rates of overdose deaths among people who use drugs. This study describes patterns and perceptions of fentanyl exposure among opioid users in Rhode Island. METHODS: A mixed methods study was conducted via questionnaire with a convenience sample of 149 individuals using illicit opioids or misusing prescription opioids in Rhode Island between January and November 2016. Of these, 121 knew of fentanyl and reported known or suspected exposure to fentanyl in the past year...
June 1, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28572737/observational-study-to-calculate-addictive-risk-to-opioids-a-validation-study-of-a-predictive-algorithm-to-evaluate-opioid-use-disorder
#10
Ashley Brenton, Steven Richeimer, Maneesh Sharma, Chee Lee, Svetlana Kantorovich, John Blanchard, Brian Meshkin
BACKGROUND: Opioid abuse in chronic pain patients is a major public health issue, with rapidly increasing addiction rates and deaths from unintentional overdose more than quadrupling since 1999. PURPOSE: This study seeks to determine the predictability of aberrant behavior to opioids using a comprehensive scoring algorithm incorporating phenotypic risk factors and neuroscience-associated single-nucleotide polymorphisms (SNPs). PATIENTS AND METHODS: The Proove Opioid Risk (POR) algorithm determines the predictability of aberrant behavior to opioids using a comprehensive scoring algorithm incorporating phenotypic risk factors and neuroscience-associated SNPs...
2017: Pharmacogenomics and Personalized Medicine
https://www.readbyqxmd.com/read/28571505/buprenorphine-implants-in-medical-treatment-of-opioid-addiction
#11
Steven Chavoustie, Michael Frost, Ole Snyder, Joel Owen, Mona Darwish, Ryan Dammerman, Victoria Sanjurjo
Opioid use disorder is a chronic, relapsing disease that encompasses use of both prescription opioids and heroin and is associated with a high annual rate of overdose deaths. Medical treatment has proven more successful than placebo treatment or psychosocial intervention, and the partial µ-opioid receptor agonist and κ-opioid receptor antagonist buprenorphine is similar in efficacy to methadone while offering lower risk of respiratory depression. However, frequent dosing requirements and potential for misuse and drug diversion contribute to significant complications with treatment adherence for available formulations...
June 2, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28567699/effects-of-nalfurafine-on-the-reinforcing-thermal-antinociceptive-and-respiratory-depressant-effects-of-oxycodone-modeling-an-abuse-deterrent-opioid-analgesic-in-rats
#12
E Andrew Townsend, Jennifer E Naylor, S Stevens Negus, Shelley R Edwards, Hina N Qureshi, Hunter W McLendon, Christopher R McCurdy, Coco N Kapanda, Jussara M do Carmo, Fernanda S da Silva, John E Hall, Kenneth J Sufka, Kevin B Freeman
RATIONALE: Strategies to reduce the misuse of mu opioid agonists are critically needed. Previous work has shown that kappa opioid agonists can diminish the abuse-related effects and augment the antinociceptive effects of mu agonists. However, use of traditional kappa agonists is limited by their dysphoric side effects. OBJECTIVES: The current study examined the effects of nalfurafine, a clinically available atypical kappa agonist, on the reinforcing, thermal antinociceptive, and respiratory-depressant effects of oxycodone in male rats...
May 31, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28562498/development-and-feasibility-of-an-academic-detailing-intervention-to-improve-prescription-drug-monitoring-program-use-among-physicians
#13
Kelly S Barth, Sarah Ball, Rachel S Adams, Ruslan Nikitin, Nikki R Wooten, Zaina P Qureshi, Mary J Larson
INTRODUCTION: South Carolina (SC) ranks 10th in opioid prescriptions per capita-33% higher than the national average. SC is also home to a large military and veteran population, and prescription opioid use for chronic pain is alarmingly common among veterans, especially those returning from Afghanistan and Iraq. This article describes the background and development of an academic detailing (AD) educational intervention to improve use of a Prescription Drug Monitoring Program among SC physicians who serve military members and veterans...
April 2017: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/28562400/prevalence-of-and-factors-related-to-prescription-opioids-benzodiazepines-and-hypnotics-among-medicare-home-health-recipients
#14
Brandi P Cotton, Matthew C Lohman, Jessica M Brooks, Karen L Whiteman, Yuhua Bao, Rebecca L Greenberg, Martha L Bruce
High rates of controlled prescription drugs are associated with cognitive impairment, falls, and misuse and dependence. Little is known about the prevalence of these medications among older adults receiving home healthcare. The purpose of this study was to determine the frequency of, and the factors related to, opioid analgesics, benzodiazepines (BNZ), and nonbenzodiazepine (NBNZH) hypnotics among a large sample of older adults entering home healthcare services. The data came from administrative records of 133 Certified Home healthcare Agencies located across 32 states...
June 2017: Home Healthcare Now
https://www.readbyqxmd.com/read/28561731/pain-and-opioids-in-cancer-care-benefits-risks-and-alternatives
#15
Mike Bennett, Judith A Paice, Mark Wallace
Pain remains common in the setting of malignancy, occurring as a consequence of cancer and its treatment. Several high-quality studies confirm that more than 50% of all patients with cancer experience moderate to severe pain. The prevalence of pain in cancer survivors is estimated to be 40%, while close to two-thirds of those with advanced disease live with pain. Progress has occurred in the management of cancer pain, yet undertreatment persists. Additionally, new challenges are threatening these advances. These challenges are numerous and include educational deficits, time restraints, and limited access to all types of care...
2017: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/28554599/pharmacokinetics-and-pharmacodynamics-of-a-buprenorphine-subcutaneous-depot-formulation-cam2038-for-once-weekly-dosing-in-patients-with-opioid-use-disorder
#16
Christian Haasen, Margareta Linden, Fredrik Tiberg
INTRODUCTION: Sublingual buprenorphine is effective for opioid dependence treatment but associated with misuse, abuse, and diversion. The present Phase I/II study evaluated a novel buprenorphine subcutaneous depot formulation for once-weekly dosing (CAM2038 q1w) in patients receiving maintenance treatment for opioid use disorder with daily sublingual buprenorphine. METHODS: After discontinuation of buprenorphine for 48h, patients received a single CAM2038 q1w dose based on their pre-study daily sublingual maintenance dose...
July 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28543422/defending-opioid-treatment-agreements-disclosure-not-promises
#17
Joshua B Rager, Peter H Schwartz
In order to receive controlled pain medications for chronic non-oncologic pain, patients often must sign a "narcotic contract" or "opioid treatment agreement" in which they promise not to give pills to others, use illegal drugs, or seek controlled medications from health care providers. In addition, they must agree to use the medication as prescribed and to come to the clinic for drug testing and pill counts. Patients acknowledge that if they violate the opioid treatment agreement (OTA), they may no longer receive controlled medications...
May 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28543168/a-new-tool-to-tackle-the-opioid-epidemic-description-utility-and-results-from-the-maine-diversion-alert-program
#18
Brian J Piper, Clare E Desrosiers, Harriet C Fisher, Kenneth L McCall, Stephanie D Nichols
STUDY OBJECTIVE: The opioid epidemic continues to impact the United States, and new strategies are needed to combat this epidemic. The objective of this study was to analyze 2015 drug arrest data from Maine's Diversion Alert program (diversionalert. org), compare arrest data between the first quarters of 2015 and 2016, and provide an analysis of the sex differences in the arrests as well as information about DA use. STUDY DESIGN: A population-based, descriptive study using data from the Maine Diversion Alert Program...
May 19, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28530896/use-and-misuse-of-opioid-agonists-in-opioid-addiction
#19
REVIEW
Vania Modesto-Lowe, Katie Swiezbin, Margaret Chaplin, Gabriela Hoefer
Although methadone (an opioid agonist) and buprenorphine (a partial opioid agonist) have evidence to support their use in treating opioid use disorder, they remain misunderstood and underutilized. In this article, we outline the risks and benefits of using these drugs as maintenance therapy in opioid-dependent patients.
May 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/28526967/update-on-barriers-to-pharmacotherapy-for-opioid-use-disorders
#20
REVIEW
Anjalee Sharma, Sharon M Kelly, Shannon Gwin Mitchell, Jan Gryczynski, Kevin E O'Grady, Robert P Schwartz
PURPOSE OF REVIEW: The recent heroin and prescription opioid misuse epidemic has led to a sharp increase in the number of opioid overdose deaths in the USA. Notwithstanding the availability of three FDA-approved medications (methadone, buprenorphine, and naltrexone) to treat opioid use disorder, these medications are underutilized. This paper provides an update from the recent peer-reviewed literature on barriers to the use of these medications. FINDINGS: These barriers are interrelated and can be categorized as financial, regulatory, geographic, attitudinal, and logistic...
June 2017: Current Psychiatry Reports
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