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https://www.readbyqxmd.com/read/28429281/impact-of-thyroid-disease-on-testicular-function
#1
REVIEW
Sandro La Vignera, Roberto Vita, Rosita A Condorelli, Laura M Mongioì, Silvia Presti, Salvatore Benvenga, Aldo E Calogero
INTRODUCTION: Testis was considered unresponsive to thyroid hormone for a long time. However, like in animals, the presence of thyroid hormone receptors in different testicular cell types was demonstrated also in humans. Accordingly, thyrotoxicosis and hypothyroidism have remarkable effects on testicular function and more extensively on fertility. REVIEW: Thyrotoxicosis and hypothyroidism are associated with changes affecting the endocrine, sexual, or reproductive functions...
April 20, 2017: Endocrine
https://www.readbyqxmd.com/read/28424174/the-clinical-value-of-regular-thyroid-function-tests-during-amiodarone-treatment
#2
Stan Benjamens, Robin P F Dullaart, Wim J Sluiter, Michiel Rienstra, Isabelle C van Gelder, Thera P Links
OBJECTIVE: Amiodarone is used for the maintenance of sinus rhythm in patients with arrhythmias, but thyroid dysfunction (amiodarone-induced thyrotoxicosis(AIT) or -hypothyroidism(AIH)) is a common adverse effect. Since the onset of AIT and AIH may be unpredictable, the value of long-term regular monitoring of amiodarone treated patients for thyroid dysfunction is still uncertain. DESIGN: We retrospectively documented the frequency at which overt thyroid dysfunction was preceded by subclinical thyroid dysfunction...
April 19, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28414788/patients-with-subclinical-hypothyroidism-before-20-weeks-of-pregnancy-have-a-higher-risk-of-miscarriage-a-systematic-review-and-meta-analysis
#3
Yibing Zhang, Haoyu Wang, Xifeng Pan, Weiping Teng, Zhongyan Shan
OBJECTIVE: To evaluate the relationship between subclinical hypothyroidism (SCH) and the risk of miscarriage before 20 weeks of pregnancy. METHODS: Literature databases were searched, including the PubMed, Web of Science, Embase and Cochrane databases, from January 1, 1980, to December 31, 2015. The following search terms were used: subclinical hypothyroidism, hypothyroidism, thyroid dysfunction, thyroid hypofunction, subclinical thyroid disease, thyroid dysfunction, pregnancy loss, abortion and miscarriage...
2017: PloS One
https://www.readbyqxmd.com/read/28412871/the-effect-of-oil-and-water-soluble-contrast-medium-in-hysterosalpingography-on-thyroid-function
#4
Shuhei So, Wakasa Yamaguchi, Hiroko Tajima, Takeshi Nakayama, Naoaki Tamura, Naohiro Kanayama, Fumiko Tawara
Hysterosalpingography (HSG) using iodinated contrast medium is X-ray diagnostic test that examines the inside of the uterus and fallopian tubes in infertile women. In this study, we compared thyroid function (thyroid stimulating hormone: TSH and free-T4: FT4 levels) after HSG with an oil-soluble contrast medium (OSCM) and a water-soluble contrast medium (WSCM). One hundred and sixty-four and 94 patients with normal thyroid function received HSG with OSCM and WSCM, respectively. Approximately 25% of the women in the OSCM group developed subclinical hypothyroidism (SCH), whereas only less than 10% of the patients in the WSCM group developed SCH...
April 17, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28406057/subclinical-hypothyroidism-should-we-treat
#5
Christopher Redford, Bijay Vaidya
Subclinical hypothyroidism (also known as compensated hypothyroidism or mild hypothyroidism) is a condition associated with a raised serum concentration of thyroid stimulating hormone (TSH) but a normal serum free thyroxine (FT4). It is common, affecting about 10% of women above the age of 55 years. Autoimmunity is the commonest cause of subclinical hypothyroidism. About 2.5% of patients with subclinical hypothyroidism progress to clinically overt hypothyroidism each year; the rate of progression is higher in patients with thyroid autoantibodies and higher thyroid stimulating hormone levels...
January 1, 2017: Post Reproductive Health
https://www.readbyqxmd.com/read/28403083/subclinical-hypothyroidism-and-the-risk-of-chronic-kidney-disease-in-t2d-subjects-a-case-control-and-dose-response-analysis
#6
Jian-Bo Zhou, Hong-Bing Li, Xiao-Rong Zhu, Hai-Lin Song, Ying-Ying Zhao, Jin-Kui Yang
Evidence indicated a positive association between subclinical hypothyroidism (SCH) and cardiovascular diseases. But the relationship between SCH and chronic kidney diseases (CKD) remains unclear. A case-control study was performed to ascertain this relationship followed by a meta-analysis. In this hospital-based, case-control study, we recruited 3270 type 2 diabetic patients with euthyroidism and 545 type 2 diabetic patients with SCH. All English studies were searched upon the relationship between SCH and CKD up to October 2016...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28402245/thyroid-hormone-therapy-for-older-adults-with-subclinical-hypothyroidism
#7
David J Stott, Nicolas Rodondi, Patricia M Kearney, Ian Ford, Rudi G J Westendorp, Simon P Mooijaart, Naveed Sattar, Carole E Aubert, Drahomir Aujesky, Douglas C Bauer, Christine Baumgartner, Manuel R Blum, John P Browne, Stephen Byrne, Tinh-Hai Collet, Olaf M Dekkers, Wendy P J den Elzen, Robert S Du Puy, Graham Ellis, Martin Feller, Carmen Floriani, Kirsty Hendry, Caroline Hurley, J Wouter Jukema, Sharon Kean, Maria Kelly, Danielle Krebs, Peter Langhorne, Gemma McCarthy, Vera McCarthy, Alex McConnachie, Mairi McDade, Martina Messow, Annemarie O'Flynn, David O'Riordan, Rosalinde K E Poortvliet, Terence J Quinn, Audrey Russell, Carol Sinnott, Jan W A Smit, H Anette Van Dorland, Kieran A Walsh, Elaine K Walsh, Torquil Watt, Robbie Wilson, Jacobijn Gussekloo
Background The use of levothyroxine to treat subclinical hypothyroidism is controversial. We aimed to determine whether levothyroxine provided clinical benefits in older persons with this condition. Methods We conducted a double-blind, randomized, placebo-controlled, parallel-group trial involving 737 adults who were at least 65 years of age and who had persisting subclinical hypothyroidism (thyrotropin level, 4.60 to 19.99 mIU per liter; free thyroxine level within the reference range). A total of 368 patients were assigned to receive levothyroxine (at a starting dose of 50 μg daily, or 25 μg if the body weight was <50 kg or the patient had coronary heart disease), with dose adjustment according to the thyrotropin level; 369 patients were assigned to receive placebo with mock dose adjustment...
April 3, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28386276/cholesterol-synthesis-increased-in-the-mmi-induced-subclinical-hypothyroidism-mice-model
#8
Yongfeng Song, Xiujuan Zhang, Wenbin Chen, Ling Gao
Subclinical hypothyroidism (SCH) is defined as increased serum thyroid-stimulating hormone (TSH) concentrations and normal serum thyroid hormone (TH) levels as well as an increased serum cholesterol level, which is an important cause of secondary hypercholesterolemia and cardiovascular diseases. Some studies have demonstrated a direct effect of TSH on cholesterol metabolism via in vivo and in vitro experiments. However, because no suitable SCH model has been established until now, the changes in cholesterol synthesis that occur in SCH patients remain unknown...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28385684/levothyroxine-shows-no-benefit-in-elderly-patients-with-subclinical-hypothyroidism-trial-finds
#9
Susan Mayor
No abstract text is available yet for this article.
April 5, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28384120/dyslipidemia-in-subclinical-hypothyroidism-requires-assessment-of-small-dense-low-density-lipoprotein-cholesterol-sdldl-c
#10
Maida Seferovic Saric, Miljenka-Jelena Jurasic, Slavica Sovic, Bojana Kranjcec, Tatjana Glivetic, Vida Demarin
BACKGROUND: Usually both hypothyroidism and hyperthyroidism are related to the cardiovascular and cerebrovascular disease development. The relationship between subclinical hypothyroidism has been widely investigated but the findings remain controversial. The aim of the present study was to evaluate the lipid profile in patients with subclinical hypothyroidism (SHypo) in comparison to controls and to determine the association of SHypo and dyslipidemia in attempt to find importance of small dense low-density lipoprotein cholesterol (sdLDL-C) in atherosclerosis...
April 6, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28377800/evaluation-of-tp-e-interval-tp-e-qt-ratio-and-tp-e-qtc-ratio-in-patients-with-subclinical-hypothyroidism
#11
Ahmet Gürdal, Hatice Eroğlu, Füsun Helvaci, Mutlu Çağan Sümerkan, Kamber Kasali, Şükrü Çetin, Gökhan Aksan, Kadriye Kiliçkesmez
BACKGROUND: Prolongation of the peak-to-end interval of the T wave (Tp-e) has been reported as associated with ventricular arrhythmias. The aim of this study was to investigate the ventricular repolarization by using the Tp-e interval, Tp-e/QT ratio and Tp-e/ QTc ratio in patients with subclinical hypothyroidism (SH). METHODS: We studied 56 volunteers: These were 28 patients with SH (mean age 45 ± 11 years) and 28 healthy subjects (mean age 34 ± 8 years). All basic biochemical parameters were analyzed and electrocardiograms (ECGs) were recorded...
March 2017: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28376799/new-association-of-bone-morphogenetic-protein-4-concentrations-with-fat-distribution-in-obesity-and-exenatide-intervention-on-it
#12
Xingchun Wang, Jiaqi Chen, Liang Li, Cui Ling Zhu, Jingyang Gao, Sharvan Rampersad, Le Bu, Shen Qu
BACKGROUND: Bone morphogenetic protein 4 (BMP-4) has been proven to regulate white adipogensis. We aimed to demonstrate the correlation of BMP-4 with fat distribution and Exenatide treatment on it. METHODS: We enrolled 69 obese patients. Anthropometric and metabolic indexes were collected. Fat distribution was measured by dual-energy X-ray absorptiometry. BPM-4 levels were assessed using enzyme-link immunosorbent assay kit. 30 obese patients were treated with Exenatide twice a day...
April 4, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28375832/fatigue-in-patients-with-systemic-sclerosis-and-hypothyroidism-a-review-of-the-literature-and-report-of-our-experience
#13
Alessandro Antonelli, Poupak Fallahi, Flavia Di Bari, Dilia Giuggioli, Silvia Martina Ferrari, Clodoveo Ferri
Persistent fatigue (defined as ongoing exhaustion, disproportionate to exertion and not adequately alleviated by rest) reduces health-related quality of life of systemic sclerosis (SSc) patients. Fatigue in SSc is associated with reduced capacity to carry out daily activities, work disability and impaired physical function. Clinical studies demonstrated a high prevalence of autoimmune thyroiditis and hypothyroidism in patients with SSc. Since hypothyroidism and the associated fatigue symptoms could be cured by L-thyroxine (L-T4) substitutive therapy, the evolution of fatigue symptoms in SSc hypothyroid patients treated with substitutive therapy has been recently evaluated, showing an amelioration of the fatigue symptoms...
April 4, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28359096/early-maternal-thyroid-function-during-gestation-is-associated-with-fetal-growth-particularly-in-male-newborns
#14
Tanja G M Vrijkotte, E Jessica Hrudey, Marcel B Twickler
Background: Intrauterine growth patterns are influenced by maternal thyroid function during gestation and by fetal sex. It is unknown, however, whether the relationships between maternal thyrotropin (TSH) and free thyroxine (fT4) levels in early pregnancy and fetal growth outcomes are modified by fetal sex. Design: Data were obtained from a community-based cohort study of pregnant women living in Amsterdam (Amsterdam Born Children and Their Development study). TSH and fT4 levels were determined during the first prenatal screening at median 13 weeks (interquartile range, 12 to 14)...
March 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28357593/the-relationship-between-subclinical-thyroid-dysfunction-and-the-risk-of-fracture-or-low-bone-mineral-density-a-systematic-review-and-meta-analysis-of-cohort-studies
#15
Ruifei Yang, Liang Yao, Yuan Fang, Jing Sun, Tiankang Guo, Kehu Yang, Limin Tian
Our aim was to assess the risk of fractures or low bone mineral density (BMD) associated with subclinical thyroid dysfunction among cohorts. We systematically searched Medline (via PubMed), EMBASE, Cochrane Library, Web of Science, CENTRAL and SinoMed up to 31 July 2016 to identify cohort studies which have analyzed associations between subclinical thyroid dysfunction and fracture or BMD. A total of 19 population-based cohorts including 79,368 participants with relationships between subclinical thyroid dysfunction and fractures or BMD were identified as eligible for this meta-analysis...
March 29, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28356660/prevalence-of-hypothyroidism-in-nondiabetic-chronic-kidney-disease-and-effect-of-thyroxine-replacement-on-estimated-glomerular-filtration-rate
#16
S Bajaj, N Purwar, A Gupta, P Gupta, A Srivastava
Reduced T3 and free T4, elevated thyroid stimulating hormone, and hyporesponsiveness to thyrotropin releasing hormone raise questions about the presence of hypothyroidism in chronic kidney disease (CKD) and raise the possibility of benefit from thyroxine supplementation. A prospective cohort study was conducted on 73 nondiabetic CKD cases. Hypothyroid patients were started on levothyroxine and were reviewed after 3 and 6 months. The mean age of study population was 42.3 ± 16.8 years. Of the total population, 32 (43...
March 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28351291/hypothyroidism-and-hyponatremia-rather-coincidence-than-causality
#17
Peter Wolf, Hannes Beiglböck, Sabina Smaijs, Thomas Wrba, Susanne Rasoul-Rockenschaub, Rodrig Marculescu, Alois Gessl, Anton Luger, Yvonne Winhofer, Michael Krebs
BACKGROUND: Hypothyroidism is referred to be a rare but possible cause of hyponatremia. However, there is only poor evidence supporting this association. Since hyponatremia and hypothyroidism are both common conditions themselves, co-occurrence does not have to be causal. METHODS: To address a potential relationship, a retrospective analysis of data from the Division of Endocrinology of the Medical University of Vienna from April 2004 to February 2016 was performed...
April 19, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28351085/thyroid-function-and-metabolic-syndrome-a-population-based-thyroid-study
#18
Ladan Mehran, Atieh Amouzegar, Parnian Kheirkhah Rahimabad, Maryam Tohidi, Zhale Tahmasebinejad, Fereidoun Azizi
The impact of thyroid dysfunction in subclinical ranges on metabolic syndrome (MetS) is not well known. The aim of the present study is to evaluate the association of thyroid dysfunction with MetS and its components. In the cross-sectional population-based Tehran Thyroid Study, out of 5 786 randomly selected participants, aged≥20 years, subjects with thyroid nodules and cancer or any severe systemic disease, those who were pregnant and those using thyroid medication were excluded, leaving 5 422 subjects to be investigated...
March 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28349231/thyrotropin-levels-are-associated-with-chronic-kidney-disease-among-healthy-subjects-in-cross-sectional-analysis-of-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#19
Érique José F Peixoto de Miranda, Márcio Sommer Bittencourt, Alessandra C Goulart, Itamar S Santos, Silvia Maria de Oliveira Titan, Roberto Marini Ladeira, Sandhi Maria Barreto, Paulo A Lotufo, Isabela Judith Martins Benseñor
BACKGROUND: Few studies have evaluated a possible relationship between thyrotropin levels and glomerular filtration rate (GFR) and albumin/creatinine ratio in euthyroid subjects. We aimed to analyze this association using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). METHODS: Cross-sectionally, we included subjects with normal thyroid function and with subclinical hypothyroidism (SCH). We excluded individuals using medications that affect thyroid function...
March 27, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28348996/subclinical-hypothyroidism-and-the-risk-of-hypercholesterolemia
#20
Indhu Aynipully Jayasingh, Paul Puthuran
INTRODUCTION: Subclinical hypothyroidism (SCH) is a condition wherein there are small elevations in thyroid stimulating hormone (TSH), yet normal circulating levels of free thyroid hormones (FT4). Alterations in thyroid function result in changes in composition and transport of lipoproteins. METHODS: The study was undertaken in the outpatient department of Lourdes hospital, Ernakulam. 110 patients between 40-69 years were studied, of which 60 were identified to have SCH based on cross-sectional survey, 50 patients were randomly selected to represent the EU group...
October 2016: Journal of Family Medicine and Primary Care
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