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Sylvia priori

Sander C J Verfaillie, Alexa Pichet Binette, Etienne Vachon-Presseau, Shirin Tabrizi, Mélissa Savard, Pierre Bellec, Rik Ossenkoppele, Philip Scheltens, Wiesje M van der Flier, John C S Breitner, Sylvia Villeneuve
BACKGROUND: Both subjective cognitive decline (SCD) and a family history of Alzheimer's disease (AD) portend risk of brain abnormalities and progression to dementia. Posterior default mode network (pDMN) connectivity is altered early in the course of AD. It is unclear whether SCD predicts similar outcomes in cognitively normal individuals with a family history of AD. METHODS: We studied 124 asymptomatic individuals with a family history of AD (age 64 ± 5 years)...
May 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Andros Tofield
No abstract text is available yet for this article.
October 14, 2017: European Heart Journal
Roy S Dwarkasing, Sylvia I Verschuuren, Geert J L H van Leenders, Loes M M Braun, Gabriel P Krestin, W Rudolph Schouten
OBJECTIVE: The purpose of this study was to assess the a priori chance that primary cystic lesions of the retrorectal space are malignant and to investigate MRI characteristics that indicate malignancy. MATERIALS AND METHODS: Patients referred to a center for colorectal surgery were recruited from 2000 to 2014. Lesions were proven by clinical assessment and histopathology. MRI was performed at 1.5 T with examinations evaluated by two radiologists. Interobserver agreement was assessed (Cohen kappa) and differences between malignant and benign lesions calculated (Fisher exact test)...
October 2017: AJR. American Journal of Roentgenology
Natalia Jaworska, Sylvia M Cox, Kevin F Casey, Isabelle Boileau, Mariya Cherkasova, Kevin Larcher, Alain Dagher, Chawki Benkelfat, Marco Leyton
BACKGROUND: Novelty-seeking (NS) and impulsive personality traits have been proposed to reflect an interplay between fronto-cortical and limbic systems, including the limbic striatum (LS). Although neuroimaging studies have provided some evidence for this, most are comprised of small samples and many report surprisingly large effects given the challenges of trying to relate a snapshot of brain function or structure to an entity as complex as personality. The current work tested a priori hypotheses about associations between striatal dopamine (DA) release, cortical thickness (CT), and NS in a large sample of healthy adults...
2017: PloS One
Sylvia Shangani, Daniel Escudero, Kipruto Kirwa, Abigail Harrison, Brandon Marshall, Don Operario
HIV testing constitutes a key step along the continuum of HIV care. Men who have sex with men (MSM) have low HIV testing rates and delayed diagnosis, especially in low-resource settings. Peer-led interventions offer a strategy to increase testing rates in this population. This systematic review and meta-analysis summarizes evidence on the effectiveness of peer-led interventions to increase the uptake of HIV testing among MSM. Using a systematic review protocol that was developed a priori, we searched PubMed, PsycINFO and CINAHL for articles reporting original results of randomized or non-randomized controlled trials (RCTs), quasi-experimental interventions, and pre- and post-intervention studies...
August 2017: AIDS Care
Carl H Backes, Brian K Rivera, Jeffrey A Bridge, Aimee K Armstrong, Brian A Boe, Darren P Berman, Tyler Fick, Ralf J Holzer, Ziyad M Hijazi, Sylvia Abadir, Henri Justino, Lisa Bergersen, Charles V Smith, Haresh Kirpalani
CONTEXT: Patent ductus arteriosus (PDA) is a precursor to morbidity and mortality. Percutaneous (catheter-based) closure is the procedure of choice for adults and older children with a PDA, but use during infancy (<1 year) is not well characterized. OBJECTIVE: Investigate the technical success and safety of percutaneous PDA closure during infancy. DATA SOURCES: Scopus, Web of Science, Embase, PubMed, and Ovid (Medline) were searched through December 2015 with no language restrictions...
February 2017: Pediatrics
Pavel Dietz, Estelle D Watson, Matteo C Sattler, Wolfgang Ruf, Sylvia Titze, Mireille van Poppel
BACKGROUND: Physical activity (PA) during pregnancy has been shown to be associated with several positive effects for mother, fetus, and offspring. Heart rate variability (HRV) is a noninvasive and surrogate marker to determine fetal overall health and the development of fetal autonomic nervous system. In addition, it has been shown to be significantly influenced by maternal behavior. However, the influence of maternal PA on HRV has not yet been systematically reviewed. Therefore, the aim of this systematic review was to assess the influence of regular maternal PA on maternal, fetal or infant HRV...
October 26, 2016: BMC Pregnancy and Childbirth
Robert Hodgson, Sylvia H Heywang-Köbrunner, Susan C Harvey, Mary Edwards, Javed Shaikh, Mick Arber, Julie Glanville
This review investigated the relative performance of digital breast tomosynthesis (DBT) (alone or with full field digital mammography (FFDM) or synthetic digital mammography) compared with FFDM alone for detecting breast cancer lesions in asymptomatic women. A systematic review was carried out according to systematic reviewing principles provided in the Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy. A protocol was developed a priori. The review was registered with PROSPERO (number CRD42014013949)...
June 2016: Breast: Official Journal of the European Society of Mastology
Sylvia Otto, Johannes Gassdorf, Kristina Nitsche, Juan Luis Gutiérrez-Chico, Aleh Kryvanos, Björn Goebel, Hans R Figulla, Tudor C Poerner
BACKGROUND: An a priori combined therapy of a bare metal stent post-dilated with a paclitaxel- -coated balloon (PCB) was investigated with optical coherence tomography (OCT) at 2 and 6 months regarding vessel response. Previous studies have shown inconsistent results and the time course of vessel healing after such an interventional strategy is unknown. METHODS: Thirty-three de novo lesions in 32 patients were electively treated. Six-month OCT analysis was available in 24 lesions...
2016: Cardiology Journal
Lidewij Henneman, Pascal Borry, Davit Chokoshvili, Martina C Cornel, Carla G van El, Francesca Forzano, Alison Hall, Heidi C Howard, Sandra Janssens, Hülya Kayserili, Phillis Lakeman, Anneke Lucassen, Sylvia A Metcalfe, Lovro Vidmar, Guido de Wert, Wybo J Dondorp, Borut Peterlin
This document of the European Society of Human Genetics contains recommendations regarding responsible implementation of expanded carrier screening. Carrier screening is defined here as the detection of carrier status of recessive diseases in couples or persons who do not have an a priori increased risk of being a carrier based on their or their partners' personal or family history. Expanded carrier screening offers carrier screening for multiple autosomal and X-linked recessive disorders, facilitated by new genetic testing technologies, and allows testing of individuals regardless of ancestry or geographic origin...
June 2016: European Journal of Human Genetics: EJHG
Wing Sun Faith Chung, Alan W Walker, Petra Louis, Julian Parkhill, Joan Vermeiren, Douwina Bosscher, Sylvia H Duncan, Harry J Flint
BACKGROUND: Dietary intake of specific non-digestible carbohydrates (including prebiotics) is increasingly seen as a highly effective approach for manipulating the composition and activities of the human gut microbiota to benefit health. Nevertheless, surprisingly little is known about the global response of the microbial community to particular carbohydrates. Recent in vivo dietary studies have demonstrated that the species composition of the human faecal microbiota is influenced by dietary intake...
January 11, 2016: BMC Biology
Sylvia Villeneuve, Gil D Rabinovici, Brendan I Cohn-Sheehy, Cindee Madison, Nagehan Ayakta, Pia M Ghosh, Renaud La Joie, Samia Kate Arthur-Bentil, Jacob W Vogel, Shawn M Marks, Manja Lehmann, Howard J Rosen, Bruce Reed, John Olichney, Adam L Boxer, Bruce L Miller, Ewa Borys, Lee-Way Jin, Eric J Huang, Lea T Grinberg, Charles DeCarli, William W Seeley, William Jagust
Amyloid-β, a hallmark of Alzheimer's disease, begins accumulating up to two decades before the onset of dementia, and can be detected in vivo applying amyloid-β positron emission tomography tracers such as carbon-11-labelled Pittsburgh compound-B. A variety of thresholds have been applied in the literature to define Pittsburgh compound-B positron emission tomography positivity, but the ability of these thresholds to detect early amyloid-β deposition is unknown, and validation studies comparing Pittsburgh compound-B thresholds to post-mortem amyloid burden are lacking...
July 2015: Brain: a Journal of Neurology
Sylvia J Hysong, LeChauncy Woodard, Jennifer H Garvin, Jeffrey Murawsky, Laura A Petersen
Published scientific protocols are advocated as a means of controlling bias in research reporting. Indeed, many journals require a study protocol with manuscript submission. However, publishing protocols of partnered research (PPR) can be challenging in light of the research model's dynamic nature, especially as no current reporting standards exist. Nevertheless, as these protocols become more prevalent, a priori documentation of methods in partnered research studies becomes increasingly important. Using as illustration a suite of studies aimed at improving coordination and communication in the primary care setting, we sought to identify challenges in publishing PPR relative to traditional designs, present alternative solutions to PPR publication, and propose an initial checklist of content to be included in protocols of partnered research...
December 2014: Journal of General Internal Medicine
Mazen Toukh, D Robert Siemens, Angela Black, Sylvia Robb, Michael Leveridge, Charles H Graham, Maha Othman
Cancer patients are at higher risk for thromboembolism compared to the normal population. This may be related to tumour burden and/or enhanced by systemic therapy. While there is ample evidence regarding venous thromboembolism, systematic studies investigating arterial thrombotic events are scarce. Conventional coagulation tests have limited capacity in evaluating the coagulability or the need for anticoagulant prophylaxis. In this pilot study, we investigated whether assessment of global haemostasis using thromboelastography (TEG) and quantification of plasma pro-coagulant microparticles can help determine the risk of adverse thrombotic events in patients with prostate cancer (PCa)...
January 2014: Thrombosis Research
Kian Kani, Vitor M Faca, Lindsey D Hughes, Wenxuan Zhang, Qiaojun Fang, Babak Shahbaba, Roland Luethy, Jonathan Erde, Joanna Schmidt, Sharon J Pitteri, Qing Zhang, Jonathan E Katz, Mitchell E Gross, Sylvia K Plevritis, Martin W McIntosh, Anjali Jain, Samir Hanash, David B Agus, Parag Mallick
Clinical oncology is hampered by lack of tools to accurately assess a patient's response to pathway-targeted therapies. Serum and tumor cell surface proteins whose abundance, or change in abundance in response to therapy, differentiates patients responding to a therapy from patients not responding to a therapy could be usefully incorporated into tools for monitoring response. Here, we posit and then verify that proteomic discovery in in vitro tissue culture models can identify proteins with concordant in vivo behavior and further, can be a valuable approach for identifying tumor-derived serum proteins...
May 2012: Molecular Cancer Therapeutics
Michail Papathomas, John Molitor, Sylvia Richardson, Elio Riboli, Paolo Vineis
BACKGROUND: Profile regression is a Bayesian statistical approach designed for investigating the joint effect of multiple risk factors. It reduces dimensionality by using as its main unit of inference the exposure profiles of the subjects that is, the sequence of covariate values that correspond to each subject. OBJECTIVES: We applied profile regression to a case-control study of lung cancer in nonsmokers, nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to estimate the combined effect of environmental carcinogens and to explore possible gene-environment interactions...
January 2011: Environmental Health Perspectives
Christoph Scherfler, Sylvia M Boesch, Eveline Donnemiller, Klaus Seppi, Helga Weirich-Schwaiger, Georg Goebel, Irene Virgolini, Gregor K Wenning, Werner Poewe
PURPOSE: The purpose of this study was to investigate the monoamine transporter status of dopamine, serotonin and norepinephrine throughout the brain in spinocerebellar ataxia type 2 (SCA2). To this end, nine patients were studied with [(123)I]beta-CIT SPECT. METHODS: Data were compared with ten age-matched healthy control subjects and ten patients with young-onset Parkinson's disease (YOPD), matched for age. Parametric SPECT images of the specific-to-non-displaceable equilibrium partition coefficient (V (3)''), which is proportional to the receptor density (B (max)), were generated...
September 2006: European Journal of Nuclear Medicine and Molecular Imaging
Jozef Bartunek, Stephanie Dimmeler, Helmut Drexler, Francisco Fernández-Avilés, Manuel Galinanes, Stefan Janssens, John Martin, Anthony Mathur, Phillipe Menasche, Sylvia Priori, Bodo Strauer, Michal Tendera, William Wijns, Andreas Zeiher et al.
A task force has been established by the European Society of Cardiology to investigate the role of progenitor/stem cell therapy in the treatment of cardiovascular disease. This article is the consensus of this group, of what clinical studies are needed in this field, and the challenges to be addressed in the translation of progenitor/stem cell biology to repair of the heart.
June 2006: European Heart Journal
F Barkhof, U Held, J H Simon, M Daumer, F Fazekas, M Filippi, J A Frank, L Kappos, D Li, S Menzler, D H Miller, J Petkau, J Wolinsky
BACKGROUND: Gadolinium enhancement is often used in randomized clinical trials to evaluate the efficacy of new drugs in multiple sclerosis (MS). Knowledge about predictors of enhancement status is important for the selection of patients for MRI monitored trials. METHODS: Data from 17 trials were available in anonymized format through the Sylvia Lawry Centre for MS Research. In an open part containing 1,328 (non primary progressive) patients, two logistic regression analyses were explored, including demographic, clinical, and MRI predictors...
November 8, 2005: Neurology
Stephen D Silberstein, Stuart R Stark, Sylvia M Lucas, Suzanne N Christie, Ronald E Degryse, Catherine C Turkel
OBJECTIVES: To identify a treatment-responsive population for botulinum toxin type A (BoNTA) and to evaluate the safety and efficacy of 3 different doses of BoNTA as prophylactic treatment of chronic daily headache (CDH). PATIENTS AND METHODS: A randomized, double-blind, placebo-controlled study of BoNTA in patients with CDH was conducted from July 6, 2001, through November 7, 2003, at 28 North American study centers. Eligible patients were injected with BoNTA at 225 U, 150 U, 75 U, or placebo and returned for additional masked treatments at day 90 and day 180...
September 2005: Mayo Clinic Proceedings
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