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https://www.readbyqxmd.com/read/29777731/tumor-necrosis-factor-receptor-2-is-required-for-ischemic-preconditioning-mediated-neuroprotection-in-the-hippocampus-following-a-subsequent-longer-transient-cerebral-ischemia
#1
Jae-Chul Lee, Chan Woo Park, Myoung Cheol Shin, Jun Hwi Cho, Hyang-Ah Lee, Young-Myeong Kim, Joon Ha Park, Ji Hyeon Ahn, Jeong Hwi Cho, Hyun-Jin Tae, In Koo Hwang, Tae-Kyeong Lee, Moo-Ho Won, Il Jun Kang
Tumor Necrosis Factor-α (TNF-α) is a proinflammatory cytokine implicated in neuronal damage in response to cerebral ischemia. Ischemic preconditioning (IPC) provides neuroprotection against a subsequent severer or longer transient ischemia by ischemic tolerance. Here, we focused on the role of TNF-α in IPC-mediated neuroprotection against neuronal death following a subsequent longer transient cerebral ischemia (TCI). Gerbils used in this study were randomly assigned to eight groups; sham group, TCI operated group, IPC plus (+) sham group, IPC + TCI operated group, sham + etanercept (an inhibitor of TNF-a) group, TCI + etanercept group, IPC + sham + etanercept group, and IPC + TCI + etanercept group...
May 16, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29775613/suppression-of-nlrp3-inflammasome-attenuates-stress-induced-depression-like-behavior-in-nlgn3-deficient-mice
#2
Ze-Qun Li, Zhi-Yuan Yan, Bo-Jun Lan, Yi-Qun Dong, Ye Xiong
Depression, regulated by central nervous system (CNS), is a significant inflammatory disorder. Neuroligin3 (NLGN3) has been implicated in brain functions. In the study, a chronic unpredictable mild stress (CUMS) model in wild type (WT) or NLGN3-knockout (KO) mice was established to explore the role of NLGN3 in regulating depression and to reveal the underlying molecular mechanism. The results indicated that NLGN3-knockout markedly reversed the loss of body weight, the reduction of sucrose consumption, the decrease of immobile time in the forced swimming tests (FST) and tail suspension tests (TST) induced by CUMS paradigm...
May 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29765402/tlr4-nf-%C3%AE%C2%BA-b-signal-involved-in-depressive-like-behaviors-and-cytokine-expression-of-frontal-cortex-and-hippocampus-in-stressed-c57bl-6-and-ob-ob-mice
#3
Yihe Wang, Jingjing Xu, Yuan Liu, Ziyang Li, Xiaohong Li
Studies found that elevated levels of cytokines such as interleukin- (IL-) 1 β , IL-6, and tumor necrosis factor- α (TNF- α ) are closely associated with the pathogenesis of depression. Obesity providing a low-grade inflammation state was proposed to be implicated in susceptibility to depression in obesity. However, the alterations of cytokines and the TLR4-NF- κ B signal in the brain of normal-weight and obese mice under stress have not been fully elucidated. This study used chronic unpredictable mild stress (CUMS) to induce a depressive-like behavior in an animal model and examine depressive-like behaviors, memory changes, and serum corticosterone levels, as well as the expressions of cytokines and NF- κ B in the frontal cortex and hippocampus...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29755904/radiation-induced-cavernous-malformation-as-a-late-sequelae-of-stereotactic-radiosurgery-for-epilepsy
#4
Ethan A Winkler, Caleb Rutledge, Mariann Ward, Tarik Tihan, Patricia K Sneed, Nicholas Barbaro, Paul Garcia, Michael McDermott, Edward F Chang
Stereotactic radiosurgery (SRS) is a promising treatment for medically intractable mesial temporal lobe epilepsy. SRS for epilepsy has had an acceptable safety profile with reports of radiation-induced vascular malformations confined to central nervous system pathologies with prominent angiogenesis - namely, primary brain tumors, metastases, and arteriovenous malformations. Theoretical risks for radiation-induced lesions following radiosurgery for epilepsy have yet to be established. Of 13 patients treated in a pilot trial for medial temporal lobe epilepsy, one developed multiple delayed radiation-induced cavernous malformations following radiosurgery...
March 11, 2018: Curēus
https://www.readbyqxmd.com/read/29736132/the-level-of-nesfatin-1-in-a-mouse-gastric-cancer-model-and-its-role-in-gastric-cancer-comorbid-with-depression
#5
Nan Zhang, Jiangbo Li, Huiling Wang, Ling Xiao, Yanyan Wei, Jing He, Gaohua Wang
Background: The incidence of depressive symptoms is higher in cancer patients. And depression can also affect the occurrence, development and outcome of cancer through the neuroendocrine-immune-network system. Objective: To study the level of Nesfatin-1 in the plasma and brain tissue and its role in the pathogenesis in gastric cancer comorbid with depression using a mouse gastric cancer model. Methods: 18 mice were randomly divided into the normal control group (NCG), gastric cancer without stress model group (GCNS), and gastric cancer combined with stress model group (GCS)...
April 25, 2018: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29735527/nuclear-pten-deficiency-causes-microcephaly-with-decreased-neuronal-soma-size-and-increased-seizure-susceptibility
#6
Atsushi Igarashi, Kie Itoh, Tatsuya Yamada, Yoshihiro Adachi, Takashi Kato, Hiromi Sesaki, Daisuke Murata, Miho Iijima
Defects in phosphatase and tensin homolog (PTEN) are associated with neurological disorders and tumors. PTEN functions at two primary intracellular locations: the plasma membrane and the nucleus. At the membrane, PTEN functions as a phosphatidylinositol (3,4,5)-trisphosphate phosphatase and suppresses PI3-kinase signaling that drives cell growth and tumorigenesis. However, the in vivo function of nuclear PTEN is unclear. Here, using CRISPR/Cas9, we generated a mouse model in which PTEN levels in the nucleus are decreased...
May 7, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29722432/transcriptome-analysis-of-different-sizes-of-3-mercaptopropionic-acid-modified-cadmium-telluride-quantum-dot-induced-toxic-effects-reveals-immune-response-in-rat-hippocampus
#7
Tianshu Wu, Xue Liang, Keyu He, Tingting Wei, Yan Wang, Lingyue Zou, Jie Lu, Ying Yao, Na Liu, Ting Zhang, Yuying Xue, Meng Tang
Recently, the increasing number of bio-safety assessments on cadmium-containing quantum dots (QDs) suggested that they could lead to detrimental effects on the central nervous system (CNS) of living organisms, but the underlying action mechanisms are still rarely reported. In this study, whole-transcriptome sequencing was performed to analyze the changes in genome-wide gene expression pattern of rat hippocampus after treatments of cadmium telluride (CdTe) QDs with two sizes to understand better the mechanisms of CdTe QDs causing toxic effects in the CNS...
May 3, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29721854/abscisic-acid-supplementation-rescues-high-fat-diet-induced-alterations-in-hippocampal-inflammation-and-irss-expression
#8
Alberto Ribes-Navarro, Mariam Atef, Sandra Sánchez-Sarasúa, María Teresa Beltrán-Bretones, Francisco Olucha-Bordonau, Ana María Sánchez-Pérez
Accumulated evidence indicates that neuroinflammation induces insulin resistance in the brain. Moreover, both processes are intimately linked to neurodegenerative disorders, including Alzheimer's disease. Potential mechanisms underlying insulin resistance include serine phosphorylation of the insulin receptor substrate (IRS) or insulin receptor (IR) misallocation. However, only a few studies have focused on IRS expression in the brain and its modulation in neuroinflammatory processes. This study used the high-fat diet (HFD) model of neuroinflammation to study the alterations of IR, an insulin-like growth factor receptor (IGF1R) and IRS expressions in the hippocampus...
May 2, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29714500/cognitive-enhancement-of-volatile-oil-from-the-stems-of-schisandra-chinensis-baill-in-alzheimer-s-disease-rats
#9
Bingyou Yang, Bo Liu, Yan Liu, Hua Han, Haixue Kuang
The volatile oil (VO), extracted from the stems of Schisandra chinensis Baill. (SCS), was separated and identified by gas chromatography - mass spectrometry. The study was devised to investigate the effects of VO on oxidative stress and cognitive deficits induced by amyloid-β (Aβ(1-42)). Alzheimer's disease (AD) models were established by injecting Aβ(1-42) into the rat hippocampus and the effects of learning and memory were observed by a Morris water maze test, immunohistological alterations, and correlative indicators covering nerve growth (brain-derived neurotrophic factor, glial-cell-derived trophic factor, and nerve growth factor), interleukin 1β, tumor necrosis factor, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), glial fibrillary acidic protein (GFAP), and microglial CD11b in AD rats...
May 1, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29710487/protective-effect-and-mechanism-of-ginsenoside-rg1-in-cerebral-ischaemia-reperfusion-injury-in-mice
#10
Le Wang, Hong Zhao, Zhen-Zhen Zhai, Li-Xin Qu
BACKGROUND: Ginsenoside Rg1 is regarded as one of main bioactive compounds responsible for pharmaceutical actions of ginseng with little toxicity and has been shown to have possibly neuroprotective effects. However, the mechanism of its neuroprotection for acute ischemic stroke is still elusive. The purpose of present study is thus to assess the neuroprotective effects of the ginsenoside Rg1 against neurological injury in a mice model of cerebral ischemia/reperfusion (I/R), and then to explore the mechanisms for these neuroprotective effects...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29706499/ink4a-arf-expression-impairs-neurogenesis-in-the-brain-of-irradiated-mice
#11
Oanh Le, Lina Palacio, Gilbert Bernier, Ines Batinic-Haberle, Gilles Hickson, Christian Beauséjour
Brain neurogenesis is severely impaired following exposure to ionizing radiation (IR). We and others have shown that the expression of the tumor suppressor gene p16INK4a is increased in tissues exposed to IR and thus hypothesized that its expression could limit neurogenesis in the irradiated brain. Here, we found that exposure to IR leads to persistent DNA damage and the expression of p16INK4a in the hippocampus and subventricular zone regions. This was accompanied by a decline in neurogenesis, as determined by doublecortin expression and bromodeoxyuridine incorporation, an effect partially restored in Ink4a/arf-null mice...
April 20, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29705395/imperatorin-ameliorates-lipopolysaccharide-induced-memory-deficit-by-mitigating-proinflammatory-cytokines-oxidative-stress-and-modulating-brain-derived-neurotropic-factor
#12
Amrita A Chowdhury, Nitin B Gawali, Prashant Shinde, Renuka Munshi, Archana R Juvekar
BACKGROUND: Lipopolysaccharide (LPS), an endotoxin from the outer membrane of Gram negative bacteria has been reported to cause neuroinflammation and learning and memory deficits. There are reports describing the beneficial effects of Imperatorin (IMP), a naturally occurring furanocoumarin in central nervous system (CNS) disorders such as anxiety and epilepsy. OBJECTIVE: In the current study, we investigated whether IMP protects against LPS mediated memory deficits and neuroinflammation...
April 26, 2018: Cytokine
https://www.readbyqxmd.com/read/29689442/ameliorating-mitochondrial-dysfunction-restores-carbon-ion-induced-cognitive-deficits-via-co-activation-of-nrf2-and-pink1-signaling-pathway
#13
Yang Liu, Jiawei Yan, Cao Sun, Guo Li, Sirui Li, Luwei Zhang, Cuixia Di, Lu Gan, Yupei Wang, Rong Zhou, Jing Si, Hong Zhang
Carbon ion therapy is a promising modality in radiotherapy to treat tumors, however, a potential risk of induction of late normal tissue damage should still be investigated and protected. The aim of the present study was to explore the long-term cognitive deficits provoked by a high-linear energy transfer (high-LET) carbon ions in mice by targeting to hippocampus which plays a crucial role in memory and learning. Our data showed that, one month after 4 Gy carbon ion exposure, carbon ion irradiation conspicuously resulted in the impaired cognitive performance, neurodegeneration and neuronal cell death, as well as the reduced mitochondrial integrity, the disrupted activities of tricarboxylic acid cycle flux and electron transport chain, and the depressed antioxidant defense system, consequently leading to a decline of ATP production and persistent oxidative damage in the hippocampus region...
April 14, 2018: Redox Biology
https://www.readbyqxmd.com/read/29687202/attenuation-of-aluminum-chloride-induced-neuroinflammation-and-caspase-activation-through-the-akt-gsk-3%C3%AE-pathway-by-hesperidin-in-wistar-rats
#14
Arokiasamy Justin-Thenmozhi, Mathiyazahan Dhivya Bharathi, Ramaraj Kiruthika, Thamilarasan Manivasagam, Anupom Borah, Musthafa Mohamed Essa
Hesperidin, a flavanoglycone abundantly present in citrus fruits, is reported to have antioxidant, anti-inflammatory, and neuroprotective properties. Previous reports from our laboratory indicated the neuroprotective effect of hesperidin against aluminum chloride (AlCl3 )-induced memory loss, acetylcholine esterase hyperactivity, oxidative stress, and enhanced expression of amyloid β protein biosynthesis-related markers. However, their role on AlCl3 -induced inflammation, caspase activation, Tau pathology, altered Akt/GSK 3β signaling pathway, and Aβ clearance marker has not yet been fully elucidated...
April 23, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29684396/jsh-23-prevents-depressive-like-behaviors-in-mice-subjected-to-chronic-mild-stress-effects-on-inflammation-and-antioxidant-defense-in-the-hippocampus
#15
Qi Wang, Xiaomei Dong, Nannan Li, Yan Wang, Xiaofeng Guan, Yiwei Lin, Jiguang Kang, Xia Zhang, Yuchen Zhang, Xiaobai Li, Tianchao Xu
Nuclear factor-kappa B (NF-κB), which is reported to play an important role in the pathogenesis of depression, also has a central role in the genesis and progression of inflammation. Here, we have targeted the nuclear translocation of NF-κB using 4-methyl-N1-(3-phenyl-propyl)-benzene-1,2-diamine (JSH-23) to elucidate its role in depression. We investigated the antidepressant-like effects of JSH-23 in the chronic mild stress (CMS) mouse model, which is a valid, reasonably reliable, and useful model of depression...
April 20, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29681766/proinflammatory-factors-mediate-paclitaxel-induced-impairment-of-learning-and-memory
#16
Zhao Li, Shuang Zhao, Hai-Lin Zhang, Peng Liu, Fei-Fei Liu, Yue-Xian Guo, Xiu-Li Wang
The chemotherapeutic agent paclitaxel is widely used for cancer treatment. Paclitaxel treatment impairs learning and memory function, a side effect that reduces the quality of life of cancer survivors. However, the neural mechanisms underlying paclitaxel-induced impairment of learning and memory remain unclear. Paclitaxel treatment leads to proinflammatory factor release and neuronal apoptosis. Thus, we hypothesized that paclitaxel impairs learning and memory function through proinflammatory factor-induced neuronal apoptosis...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29680253/longitudinal-study-of-irradiation-induced-brain-microstructural-alterations-with-s-index-a-diffusion-mri-biomarker-and-mr-spectroscopy
#17
Elodie Anne Pérès, Olivier Etienne, Antoine Grigis, Fawzi Boumezbeur, François Dominique Boussin, Denis Le Bihan
PURPOSE: Radiation therapy is widely used for the treatment of brain tumors, but it may lead to severe cognitive impairments. Previous studies have shown that ionizing irradiation induces demyelination, blood-brain barrier alterations, and impaired neurogenesis in animal models. Hence, noninvasive and sensitive biomarkers of irradiation injury are needed to investigate these effects in patients and improve radiation therapy protocols. METHODS AND MATERIALS: The heads of 3-month-old male C57BL/6RJ mice (15 control mice and 15 irradiated mice) were exposed to radiation doses of 3 fractions of 5 Gy from a 60 Co source with a medical irradiator...
February 2, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29678518/pattern-recognition-receptors-mediate-pro-inflammatory-effects-of-extracellular-mitochondrial-transcription-factor-a-tfam
#18
Stephanie M Schindler, Matthew G Frank, Jessica L Annis, Steven F Maier, Andis Klegeris
Neuroinflammation is a common pathogenic mechanism for a number of neurodegenerative disorders including Alzheimer's and Parkinson's diseases. Microglia, the immune cells of the brain, contribute to the onset and progression of the neuroinflammation observed in these diseases. Microglia become activated and initiate an inflammatory response by interacting with a diverse set of molecules, including the group of endogenous proteins released upon cell damage, termed damage-associated molecular patterns (DAMPs)...
April 17, 2018: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29676697/the-transcortical-equatorial-approach-for-gliomas-of-the-mesial-temporal-lobe-techniques-and-functional-outcomes
#19
Ramin A Morshed, Jacob S Young, Seunggu J Han, Shawn L Hervey-Jumper, Mitchel S Berger
OBJECTIVE Many surgical approaches have been described for lesions within the mesial temporal lobe (MTL), but there are limited reports on the transcortical approach for the resection of tumors within this region. Here, the authors describe the technical considerations and functional outcomes in patients undergoing transcortical resection of gliomas of the MTL. METHODS Patients with a glioma (WHO grades I-IV) located within the MTL who had undergone the transcortical approach in the period between 1998 and 2016 were identified through the University of California, San Francisco (UCSF) tumor registry and were classified according to tumor location: preuncus, uncus, hippocampus/parahippocampus, and various combinations of the former groups...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29649942/blocking-tnf-%C3%AE-expression-prevents-blast-induced-excitatory-inhibitory-synaptic-imbalance-and-pv-interneuron-loss-in-the-hippocampus
#20
Weihua Wang, Alexander Kevin Zinsmaier, Ethan Firestone, Ruizhu Lin, Tatiana A Yatskievych, Sungchil Yang, Jinsheng Zhang, Shaowen Bao
Traumatic brain injury (TBI) is a major cause of neurological disorder and death in civilian and military populations (citation?). It comprises two components-direct injury from the traumatic impact and secondary injury from ensuing neural inflammatory responses. Blocking tumor necrosis factor-alpha (TNF-α), a central regulator of neural inflammation, has been shown to improve functional recovery after TBI. However, the mechanisms underlying those therapeutic effects are still poorly understood. Here we examined effects of 3,6'-dithiothalidomide (dTT), a potentially therapeutic TNF-α inhibitor, in mice with blast-induced TBI...
April 13, 2018: Journal of Neurotrauma
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