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https://www.readbyqxmd.com/read/28719887/anesthetic-management-of-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-crs-hipec-the-importance-of-hydro-electrolytic-and-acid-basic-control
#1
Fabrício Tavares Mendonça, Marília Moreira Guimarães, Sérgio Honorato de Matos, Rúbia Garcia Dusi
JUSTIFICATION AND OBJECTIVES: Patients affected by gynecological or gastrointestinal tract neoplasms that evolve to peritoneal carcinomatosis experience a significant drop in their quality of life, high morbidity and short survival times with currently available chemotherapeutic schemes. The surgical treatment based on cytoreduction and the employment of hyperthermic intraperitoneal chemotherapy in the intra-operative period is a true challenge to anesthesiologist. CASE REPORT: A 67 years old patient diagnosed with mucinous adenocarcinoma of the Appendix associated with mucinous carcinomatosis, was submitted to cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), under general anesthesia and epidural block...
July 10, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28719865/antioxidant-effect-of-exercise-exploring-the-role-of-the-mitochondrial-complex-i-superassembly
#2
J R Huertas, S Al Fazazi, A Hidalgo-Gutierrez, L C López, R A Casuso
Mitochondrial respiratory complexes become assembled into supercomplexes (SC) under physiological conditions. One of the functional roles of these entities is the limitation of reactive oxygen species (ROS) produced by complex I (CI) of the respiratory chain. We sought to determine whether the systemic antioxidant effect of exercise is mediated by the assembly of mitochondrial CIs into SCs in rats. Male Wistar rats were exercise trained or remained sedentary for ten weeks; then, blood samples were collected, and the gastrocnemius muscle was isolated...
July 11, 2017: Redox Biology
https://www.readbyqxmd.com/read/28719620/endurance-performance-and-energy-metabolism-during-exercise-in-mice-with-a-muscle-specific-defect-in-the-control-of-branched-chain-amino-acid-catabolism
#3
Minjun Xu, Yasuyuki Kitaura, Takuya Ishikawa, Yoshihiro Kadota, Chihaya Terai, Daichi Shindo, Takashi Morioka, Miki Ota, Yukako Morishita, Kengo Ishihara, Yoshiharu Shimomura
It is known that the catabolism of branched-chain amino acids (BCAAs) in skeletal muscle is suppressed under normal and sedentary conditions but is promoted by exercise. BCAA catabolism in muscle tissues is regulated by the branched-chain α-keto acid (BCKA) dehydrogenase complex, which is inactivated by phosphorylation by BCKA dehydrogenase kinase (BDK). In the present study, we used muscle-specific BDK deficient mice (BDK-mKO mice) to examine the effect of uncontrolled BCAA catabolism on endurance exercise performance and skeletal muscle energy metabolism...
2017: PloS One
https://www.readbyqxmd.com/read/28715593/physical-exercise-improves-total-antioxidant-capacity-and-gene-expression-in-rat-hippocampal-tissue
#4
F Franzoni, G Federighi, J Fusi, E Cerri, R Banducci, A Petrocchi, A Innocenti, C Pruneti, S Daniele, S Pellegrini, C Martini, R Scuri, F Galetta
Exercise may exert beneficial effects on cognitive functions and play an important role in the prevention of neurodegenerative diseases. Such effects seem to be mediated by changes in anti-oxidative status, but limited information is available on the nature of molecular pathways supporting the antioxidant effects of exercise in the brain. In this study 3-5-month-old male Wistar albino rats were subjected to three times/week moderate intensity exercise on a rodent treadmill for a period of 6 weeks. The tissue antioxidant activity towards various reactive oxygen species (ROS) was determined in the hippocampus...
July 1, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/28713486/concurrent-aerobic-and-resistance-training-has-anti-inflammatory-effects-and-increases-both-plasma-and-leukocyte-levels-of-igf-1-in-late-middle-aged-type-2-diabetic-patients
#5
Giosuè Annibalini, Francesco Lucertini, Deborah Agostini, Luciana Vallorani, Annamaria Gioacchini, Elena Barbieri, Michele Guescini, Lucia Casadei, Annunziata Passalia, Marta Del Sal, Giovanni Piccoli, Mauro Andreani, Ario Federici, Vilberto Stocchi
Type 2 diabetes (T2D) is an age-related chronic disease associated with metabolic dysregulation, chronic inflammation, and activation of peripheral blood mononuclear cells (PBMC). The aim of this study was to assess the effects of a concurrent exercise training program on inflammatory status and metabolic parameters of T2D patients. Sixteen male patients (age range 55-70) were randomly assigned to an intervention group (n = 8), which underwent a concurrent aerobic and resistance training program (3 times a week; 16 weeks), or to a control group, which followed physicians' usual diabetes care advices...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28713464/a-rapidly-incremented-tethered-swimming-test-for-defining-domain-specific-training-zones
#6
Dalton M Pessôa Filho, Leandro O C Siqueira, Astor R Simionato, Mário A C Espada, Daniel S Pestana, Fred J DiMenna
The purpose of this study was to investigate whether a tethered-swimming incremental test comprising small increases in resistive force applied every 60 seconds could delineate the isocapnic region during rapidly-incremented exercise. Sixteen competitive swimmers (male, n = 11; female, n = 5) performed: (a) a test to determine highest force during 30 seconds of all-out tethered swimming (Favg) and the ΔF, which represented the difference between Favg and the force required to maintain body alignment (Fbase), and (b) an incremental test beginning with 60 seconds of tethered swimming against a load that exceeded Fbase by 30% of ΔF followed by increments of 5% of ΔF every 60 seconds...
June 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28712259/four-week-living-high-training-low-program-enhances-3000-m-and-5000-m-time-trials-by-improving-energy-metabolism-during-submaximal-exercise-in-athletes
#7
Hun-Young Park, Sungho Kim, Sang-Seok Nam
PURPOSE: This study aimed to determine the effect of a 4-week living high training low (LHTL) versus a living low training low (LLTL) program on energy metabolism during submaximal exercise and 3000-m and 5000-m time trial (TT) in athletes. METHODS: Male athletes (n = 20) were randomly assigned to the LLTL (n = 10, living at 1000 m and training at 700-1330 m) and LHTL (n = 10, living at simulated 3000 m and training at 700-1330 m) groups. We compared energy metabolisms during submaximal exercise on a treadmill and aerobic exercise performance (3000 m and 5000 m TT) before and after 4 weeks of training...
March 31, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28711517/prevention-of-type-2-diabetes-mellitus-in-polycystic-ovary-syndrome-a-review
#8
REVIEW
Safa Anwar, Nigar Shikalgar
Polycystic ovary syndrome (PCOS) is recognized as one of the most common endocrinopathies in women of reproductive age, associated with metabolic sequelae which includes increased risk factors for impaired glucose tolerance (IGT), type 2 diabetes mellitus (DM2) and cardiovascular disease (CVD). The adverse effects of DM2 affects a woman throughout her lifespan. Health care expenditure of DM2 highlights the need for prevention through appropriate screening, diagnosis and intervention. Lifestyle modification (LSM) programs that include diet and/or physical activity are suggested for patients characterized as prediabetic to delay the onset of adult DM2...
July 8, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28706859/role-of-metabolic-stress-for-enhancing-muscle-adaptations-practical-applications
#9
REVIEW
Marcelo Conrado de Freitas, Jose Gerosa-Neto, Nelo Eidy Zanchi, Fabio Santos Lira, Fabrício Eduardo Rossi
Metabolic stress is a physiological process that occurs during exercise in response to low energy that leads to metabolite accumulation [lactate, phosphate inorganic (Pi) and ions of hydrogen (H(+))] in muscle cells. Traditional exercise protocol (i.e., Resistance training) has an important impact on the increase of metabolite accumulation, which influences hormonal release, hypoxia, reactive oxygen species (ROS) production and cell swelling. Changes in acute exercise routines, such as intensity, volume and rest between sets, are determinants for the magnitude of metabolic stress, furthermore, different types of training, such as low-intensity resistance training plus blood flow restriction and high intensity interval training, could be used to maximize metabolic stress during exercise...
June 26, 2017: World Journal of Methodology
https://www.readbyqxmd.com/read/28706490/effects-of-6-weeks-high-intensity-interval-training-in-schoolchildren-with-insulin-resistance-influence-of-biological-maturation-on-metabolic-body-composition-cardiovascular-and-performance-non-responses
#10
Cristian Alvarez, Rodrigo Ramírez-Campillo, Robinson Ramírez-Vélez, Mikel Izquierdo
Background: Previous studies have observed significant heterogeneity in the magnitude of change in measures of metabolic response to exercise training. There are a lack of studies examining the prevalence of non-responders (NRs) in children while considering other potential environmental factors involved such as biological maturation. Aim: To compare the effects and prevalence of NRs to improve the insulin resistance level (by HOMA-IR), as well as to other anthropometric, cardiovascular, and performance co-variables, between early (EM) and normal maturation (NM) in insulin-resistance schoolchildren after 6-weeks of HIIT...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28706378/soft-tissue-damage-during-total-knee-arthroplasty-focus-on-tourniquet-induced-metabolic-and-ionic-muscle-impairment
#11
REVIEW
Constantin Mayer, Alexander Franz, Jan-Frieder Harmsen, Fina Queitsch, Michael Behringer, Johannes Beckmann, Rüdiger Krauspe, Christoph Zilkens
PURPOSE: Advantages of tourniquet use in TKA include benefits for surgeons and patients, varying from a bloodless operation site to a reduced intervention time. The time under ischemia and the reperfusion period are crucial phases for affected soft-tissue, most commonly the extensor mechanism. CASE REPORTS: documented its impact on soft-tissue, ranging from necrotic muscle damage to systemic inflammation. Recently, research regarding tourniquet application patterns discuss clinical outcome parameters in the context of soft-tissue damage, excluding the underlying pathophysiological mechanisms...
September 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28705993/effects-of-%C3%AE-hydroxy-%C3%AE-methylbutyrate-hmb-on-skeletal-muscle-mitochondrial-content-and-dynamics-and-lipids-after-10-days-of-bed-rest-in-older-adults
#12
Robert A Standley, Giovanna Distefano, Suzette L Pereira, Min Tian, Owen J Kelly, Paul M Coen, Nicolaas E P Deutz, Robert R Wolfe, Bret H Goodpaster
Loss of muscle mass during periods of disuse likely has negative health consequences for older adults. We have previously shown that β-hydroxy-β-methylbutyrate (HMB) supplementation during 10 days of strict bed rest (BR) attenuates the loss of lean mass in older adults. To elucidate potential molecular mechanisms of HMB effects on muscle during bed rest and resistance training rehabilitation (RT), we examined mediators of skeletal muscle mitochondrial dynamics, autophagy and atrophy, and intramyocellular lipids...
July 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28704562/cerebral-18f-fdg-pet-in-macrophagic-myofasciitis-an-individual-svm-based-approach
#13
Paul Blanc-Durand, Axel Van Der Gucht, Eric Guedj, Mukedaisi Abulizi, Mehdi Aoun-Sebaiti, Lionel Lerman, Antoine Verger, François-Jérôme Authier, Emmanuel Itti
INTRODUCTION: Macrophagic myofasciitis (MMF) is an emerging condition with highly specific myopathological alterations. A peculiar spatial pattern of a cerebral glucose hypometabolism involving occipito-temporal cortex and cerebellum have been reported in patients with MMF; however, the full pattern is not systematically present in routine interpretation of scans, and with varying degrees of severity depending on the cognitive profile of patients. Aim was to generate and evaluate a support vector machine (SVM) procedure to classify patients between healthy or MMF 18F-FDG brain profiles...
2017: PloS One
https://www.readbyqxmd.com/read/28702901/implications-of-impaired-endurance-peffects-of-endurance-training-orformance-following-single-bouts-of-resistance-training-an-alternate-concurrent-training-perspective
#14
REVIEW
Kenji Doma, Glen B Deakin, David J Bentley
A single bout of resistance training induces residual fatigue, which may impair performance during subsequent endurance training if inadequate recovery is allowed. From a concurrent training standpoint, such carry-over effects of fatigue from a resistance training session may impair the quality of a subsequent endurance training session for several hours to days with inadequate recovery. The proposed mechanisms of this phenomenon include: (1) impaired neural recruitment patterns; (2) reduced movement efficiency due to alteration in kinematics during endurance exercise and increased energy expenditure; (3) increased muscle soreness; and (4) reduced muscle glycogen...
July 12, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28702444/combined-training-strength-plus-aerobic-potentiates-a-reduction-in-body-fat-but-only-functional-training-reduced-low-density-lipoprotein-cholesterol-in-postmenopausal-women-with-a-similar-training-load
#15
Fabrício Eduardo Rossi, Ana Claudia S Fortaleza, Lucas M Neves, Tiego A Diniz, Marcela R de Castro, Camila Buonani, Jorge Mota, Ismael F Freitas
The aim of this study was to compare the effects of combined (CT; strength plus aerobic) and functional training (FT) on the body composition and metabolic profile with a similar training load in postmenopausal women. The participants were divided into three groups: CT (n=20), FT (n=17), and control group (CG, n=15). The trunk FM, fat mass (FM), percentage of FM (FM%), and fat-free mass were estimated by dual-energy X-ray absorptiometry. The metabolic profile, glucose, triacylglycerol, total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol (LDL-c) were assessed...
June 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/28700515/mechanical-metabolic-and-perceptual-acute-responses-to-different-set-configurations-in-full-squat
#16
J M González-Hernádez, A García-Ramos, F Capelo-Ramírez, A Castaño-Zambudio, G Marquez, D Boullosa, P Jiménez-Reyes
This study aimed to compare mechanical, metabolic, and perceptual responses between two traditional (TR) and four cluster (CL) set configurations. In a counterbalanced randomized order, 11 men were tested with the following protocols in separate sessions (sets × repetitions [inter-repetition rest]): TR1: 3×10 [0-s]; TR2: 6×5 [0-s]; CL1: 3×10 [10-s]; CL2: 3×10 [15-s]; CL3: 3×10 [30-s]); CL4: 1×30 [15-s]). The exercise (full-squat), number of repetitions (30), inter-set rest (5 min), and resistance applied (10RM) was the same for all set configurations...
July 8, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28700185/-dialysis-and-cookers-a-project-for-the-empowerment-of-patients-in-managing-their-own-chronic-renal-failure
#17
REVIEW
Mara Cabibbe, Alberto Montoli, Franca Cassaro, Paola Cortesi, Rossana D'Oria, Michela Izzo, Monica Grotti, Nadia Manca, Filomena Marino, Cecilia Biazzi, Giuliano Cingoli, Giacomo Colussi
The phosphate and potassium control is indispensable to dominate the secondary hyperparathyroidism and reduce cardiovascular mortality in dialysis patients. Most of them receive only theoretical nutritional information. We therefore organized a cooking workshop for dialysis patients, with a multidisciplinary team consisting of nurses, nephrologists, a dietitian and a professional chef, to directly teach the patients and their families how to realize a low phosphorus and potassium menu, assessing the proper use of phosphate binders, and blood tests at baseline and at three and six months...
June 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/28698349/a-pilot-randomised-controlled-trial-of-a-periodised-resistance-training-and-protein-supplementation-intervention-in-prostate-cancer-survivors-on-androgen-deprivation-therapy
#18
Jacqueline L Kiwata, Tanya B Dorff, E Todd Schroeder, George J Salem, Christianne J Lane, Judd C Rice, Mitchell E Gross, Christina M Dieli-Conwright
INTRODUCTION: Prostate cancer survivors (PCS) receiving androgen deprivation therapy (ADT) experience deleterious side effects such as unfavourable changes in cardiometabolic factors that lead to sarcopenic obesity and metabolic syndrome (MetS). While loss of lean body mass (LBM) compromises muscular strength and quality of life, MetS increases the risk of cardiovascular disease and may influence cancer recurrence. Exercise can improve LBM and strength, and may serve as an alternative to the pharmacological management of MetS in PCS on ADT...
July 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28697018/the-renaissance-man-of-burn-surgery-basil-a-pruitt-jr
#19
Karel D Capek, Guillermo Foncerrada, R Patrick Clayton, Michaela Sljivich, Charles D Voigt, Gabriel Hundeshagen, Janos Cambiaso-Daniel, Craig Porter, Ashley Guillory, David N Herndon
Dr. Basil A. Pruitt Jr., a consummate clinical and translational surgeon-scientist, has been spent over half a century at the forefront of an advancing standard of burn care. Commanding the US Army Institute for Surgical Research in San Antonio, he trained generations of leading burn clinicians and allied scientists. At his direction, there were forged discoveries in resuscitation from shock, treatment of inhalation injury, control of burn-related infections, prevention of iatrogenic complications, and understanding the sympathetic, endocrine, and immune responses to burn injury...
July 8, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28696380/whey-protein-supplementation-enhances-whole-body-protein-metabolism-and-performance-recovery-after-resistance-exercise-a-double-blind-crossover-study
#20
Daniel W D West, Sidney Abou Sawan, Michael Mazzulla, Eric Williamson, Daniel R Moore
No study has concurrently measured changes in free-living whole body protein metabolism and exercise performance during recovery from an acute bout of resistance exercise. We aimed to determine if whey protein ingestion enhances whole body net protein balance and recovery of exercise performance during overnight (10 h) and 24 h recovery after whole body resistance exercise in trained men. In a double-blind crossover design, 12 trained men (76 ± 8 kg, 24 ± 4 years old, 14% ± 5% body fat; means ± standard deviation (SD)) performed resistance exercise in the evening prior to consuming either 25 g of whey protein (PRO; MuscleTech 100% Whey) or an energy-matched placebo (CHO) immediately post-exercise (0 h), and again the following morning (~10 h of recovery)...
July 11, 2017: Nutrients
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