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https://www.readbyqxmd.com/read/28214173/pyrocarbon-interposition-shoulder-arthroplasty-preliminary-results-from-a-prospective-multicenter-study-at-2-years-of-follow-up
#1
Jérôme Garret, Arnaud Godeneche, Pascal Boileau, Daniel Molé, Mikael Etzner, Luc Favard, Christophe Levigne, François Sirveaux, Marc-Olivier Gauci, Charles Dezaly, Gilles Walch
BACKGROUND: The concept of free interposition arthroplasty proved successful for small joints of the hand, wrist, and foot, particularly after the use of implants coated with pyrocarbon, which enhanced their tribologic and elastic properties. The present study reports preliminary outcomes of a pyrocarbon-coated interposition shoulder arthroplasty (PISA) implant. METHODS: This was a prospective study of 67 consecutive patients who underwent shoulder PISA at 9 centers...
February 14, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28212983/acircularity-index-and-axis-ratio-of-the-foveal-avascular-zone-in-diabetic-eyes-and-healthy-controls-measured-by-optical-coherence-tomography-angiography
#2
Brian D Krawitz, Shelley Mo, Lawrence S Geyman, Steven A Agemy, Nicole K Scripsema, Patricia M Garcia, Toco Y P Chui, Richard B Rosen
Given the complexity of the current system used to stage diabetic retinopathy (DR) and the risks and limitations associated with intravenous fluorescein angiography (IVFA), noninvasive quantification of DR severity is desirable. We examined the utility of acircularity index and axis ratio of the foveal avascular zone (FAZ), metrics that can noninvasively quantify the severity of diabetic retinopathy without the need for axial length to correct for individual retinal magnification. A retrospective review was performed of type 2 diabetics and age-matched controls imaged with optical coherence tomography angiography (OCTA)...
February 14, 2017: Vision Research
https://www.readbyqxmd.com/read/28212878/evaluation-of-macular-vascular-abnormalities-identified-by-optical-coherence-tomography-angiography-in-sickle-cell-disease
#3
Ian C Han, Mongkol Tadarati, Katia D Pacheco, Adrienne W Scott
PURPOSE: To evaluate macular vascular flow abnormalities identified by optical coherence tomography angiography (OCT-A) in patients with various sickle cell genotypes. DESIGN: Prospective, observational case series. METHODS: This is a single institution case series of adult patients with various sickle cell genotypes. All patients underwent macular OCT-A (Avanti RTVue XR, Optovue Inc, Fremont, CA). Images were analyzed qualitatively for areas of flow loss and quantitatively for measures of foveal avascular area, parafoveal flow, and vascular density...
February 14, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28212664/the-impact-of-high-total-cholesterol-and-high-low-density-lipoprotein-on-avascular-necrosis-of-the-femoral-head-in-low-energy-femoral-neck-fractures
#4
Xianshang Zeng, Ke Zhan, Lili Zhang, Dan Zeng, Weiguang Yu, Xinchao Zhang, Mingdong Zhao, Zhicheng Lai, Runzhen Chen
BACKGROUND: Avascular necrosis of the femoral head (AVNFH) typically constitutes 5 to 15% of all complications of low-energy femoral neck fractures, and due to an increasingly ageing population and a rising prevalence of femoral neck fractures, the number of patients who develop AVNFH is increasing. However, there is no consensus regarding the relationship between blood lipid abnormalities and postoperative AVNFH. The purpose of this retrospective study was to investigate the relationship between blood lipid abnormalities and AVNFH following the femoral neck fracture operation among an elderly population...
February 17, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28211261/early-microvascular-retinal-changes-in-optical-coherence-tomography-angiography-in-patients-with-type-1-diabetes-mellitus
#5
Joseph M Simonett, Fabio Scarinci, Fabiana Picconi, Paola Giorno, Daniele De Geronimo, Antonio Di Renzo, Monica Varano, Simona Frontoni, Mariacristina Parravano
PURPOSE: Diabetic retinopathy (DR) can lead to significant vision loss and blindness and has a particularly high prevalence in patients with type 1 diabetes (DM1). In this study, we investigate quantitative differences in optical coherence tomography angiography (OCTA) data between DM1 patients with no or mild signs of retinopathy and non-diabetic subjects. METHODS: Optical coherence tomography angiography (OCTA) imaging was performed on DM1 patients with no or mild nonproliferative diabetic retinopathy and healthy, age-matched controls...
February 16, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28211206/variable-familial-exudative-vitreoretinopathy-in-a-family-harbouring-variants-in-both-fzd4-and-tspan12
#6
Patrik Schatz, Arif O Khan
PURPOSE: To report a family affected by familial exudative vitreoretinopathy (FEVR) in which more severe disease phenotypes segregated with digenic rather than monogenic variants in FEVR-related genes. METHODS: Phenotype was documented with high-resolution imaging of retinal structure and wide-field fundus photography. Next-generation sequencing (NGS) of known genes involved in FEVR was performed. RESULTS: Three affected individuals within a family with FEVR presented with variable disease severity...
February 16, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28210226/combination-of-collagen-based-scaffold-and-bioactive-factors-induces-adipose-derived-mesenchymal-stem-cells-chondrogenic-differentiation-in-vitro
#7
Giovanna Calabrese, Stefano Forte, Rosario Gulino, Francesco Cefalì, Elisa Figallo, Lucia Salvatorelli, Eugenia T Maniscalchi, Giuseppe Angelico, Rosalba Parenti, Massimo Gulisano, Lorenzo Memeo, Raffaella Giuffrida
Recently, multipotent mesenchymal stem cells (MSCs) have attracted much attention in the field of regenerative medicine due to their ability to give rise to different cell types, including chondrocytes. Damaged articular cartilage repair is one of the most challenging issues for regenerative medicine, due to the intrinsic limited capability of cartilage to heal because of its avascular nature. While surgical approaches like chondral autografts and allografts provide symptoms and function improvement only for a short period, MSC based stimulation therapies, like microfracture surgery or autologous matrix-induced chondrogenesis demonstrate to be more effective...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28207964/impaired-nephrogenesis-in-neonatal-rats-with-oxygen-induced-retinopathy
#8
Mayu Nakagawa, Naoto Nishizaki, Amane Endo, Tomonosuke Someya, Yuta Saito, Akira Mizutani, Taichi Hara, Yayoi Murano, Koji Sakuraya, Satoshi Hara, Daisuke Umino, Daishi Hirano, Shuichiro Fujinaga, Yoshiyuki Ohtomo, Toshiaki Shimizu
OBJECTIVES: Preterm neonates are born while nephrogenesis is ongoing and are commonly exposed to factors in a hyperoxic environment that can impair renal development. Oxidative stress has also been implicated in the development of retinopathy of prematurity (ROP). The rat model of oxygen-induced retinopathy (OIR) is the most clinically relevant model of ROP because its biologic features closely resemble those of ROP in preterm infants. We investigated impaired renal development in a rat model of OIR...
February 16, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28203200/late-onset-inadvertent-bleb-formation-following-pars-plana-m3-molteno-implant-tube-obstruction
#9
Anmar M Abdul-Rahman, Anthony Molteno
PURPOSE: To report a case of inadvertent bleb formation presenting 18 months after pars plana M3 Molteno implant tube obstruction in a patient with mixed mechanism glaucoma. MATERIALS AND METHODS: An 84-year-old Caucasian male with mixed mechanism glaucoma underwent slit-lamp examination, gonioscopy, colour anterior segment photography and anterior segment optical coherence tomography (AS-OCT). RESULTS: An inadvertent bleb developed 18 months after pars plana implant tube re-positioning with a 6/0 Vicryl tie ligature...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28198007/modulating-tumor-hypoxia-by-nanomedicine-for-effective-cancer-therapy
#10
REVIEW
Rana Jahanban-Esfahlan, Miguel de la Guardia, Delshad Ahmadi, Bahman Yousefi
Hypoxia, a characteristic feature of tumors, is indispensable to tumor angiogenesis, metastasis, and multi drug resistance. Hypoxic avascular regions, deeply embedded inside the tumors significantly hinder delivery of therapeutic agents. The low oxygen tension results in resistance to the current applied anti-cancer therapeutics including radiotherapy, chemotherapy and photodynamic therapy, the efficacy of which is firmly tied to the level of tumor oxygen supply. However, emerging data indicate that nanocarriers/nanodrugs can offer substantial benefits to improve the efficacy of current therapeutics, through modulation of tumor hypoxia...
February 15, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28196058/retinal-capillary-density-in-patients-with-birdshot-chorioretinopathy
#11
Philipp K Roberts, Peter L Nesper, Debra A Goldstein, Amani A Fawzi
PURPOSE: To quantify retinal capillary density and determine its correlation with visual acuity in patients with birdshot chorioretinopathy (BCR). METHODS: Patients with BCR and age-matched controls were imaged using a commercially available spectral domain optical coherence tomography angiography system (RTVue- XR Avanti; Optovue, Inc). We used the integrated software of the optical coherence tomography angiography device to analyze the foveal avascular zone area and the capillary density in the full retina as well as in the superficial capillary plexus and deep capillary plexus...
February 10, 2017: Retina
https://www.readbyqxmd.com/read/28195189/protective-effect-of-maternal-uteroplacental-insufficiency-on-oxygen-induced-retinopathy-in-offspring-removing-bias-of-premature-birth
#12
Silke Becker, Haibo Wang, Baifeng Yu, Randy Brown, Xiaokun Han, Robert H Lane, M Elizabeth Hartnett
To address the hypothesis that maternal uteroplacental insufficiency (UPI) increases severity of retinopathy of prematurity, we developed a composite rat model of UPI and oxygen-fluctuations and removed premature birth as a confounding factor. Timed-pregnant Sprague-Dawley dams underwent bilateral uterine artery ligation or anesthesia (control) at e19.5. Full-term pups developed in room air (RA) or an oxygen-induced retinopathy (OIR) model. Isolectin-stained retinal flat-mounts were analyzed for percent of areas of avascular/total retina (AVA) and of intravitreal neovascular/total retina (IVNV)...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28194709/high-survivorship-and-little-osteoarthritis-at-10-year-followup-in-scfe-patients-treated-with-a-modified-dunn-procedure
#13
Kai Ziebarth, Milan Milosevic, Till D Lerch, Simon D Steppacher, Theddy Slongo, Klaus A Siebenrock
BACKGROUND: The modified Dunn procedure has the potential to restore the anatomy in hips with slipped capital femoral epiphyses (SCFE) while protecting the blood supply to the femoral head and minimizing secondary impingement deformities. However, there is controversy about the risks associated with the procedure and mid- to long-term data on clinical outcomes, reoperations, and complications are sparse. QUESTIONS/PURPOSES: Among patients treated with a modified Dunn procedure for SCFE, we report on (1) hip pain and function as measured by the Merle d'Aubigné and Postel score, Drehmann sign, anterior impingement test, limp, and ROM; (2) the cumulative survivorship at minimum 10-year followup with endpoints of osteoarthritis (OA) progression (at least one Tönnis grade), subsequent THA, or a Merle d'Aubigné and Postel score < 15; (3) radiographic anatomy of the proximal femur measured by slip angle, α angle, Klein line, and sphericity index; and (4) the risk of subsequent surgery and complications...
February 13, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28194387/arthroscopic-subcapital-realignment-osteotomy-in-chronic-and-stable-slipped-capital-femoral-epiphysis-early-results
#14
Bruno Dutra Roos, Marcelo Camargo de Assis, Milton Valdomiro Roos, Antero Camisa Júnior, Ezequiel Moreno Ungaretti Lima, Rodolfo Cavanus Pagani
OBJECTIVE: This study aimed to evaluate the clinical and radiographic outcomes, as well as the complications of arthroscopic subcapital realignment osteotomy in chronic and stable slipped capital femoral epiphysis (SCFE). As indicated by the literature review, this is the first time this type of arthroscopic osteotomy was described. METHODS: Between June 2012 and December 2014, seven patients were submitted to arthroscopic subcapital realignment osteotomy in chronic and stable SCFE...
January 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28193015/derivatization-strategies-for-the-detection-of-triamcinolone-acetonide-in-cartilage-by-using-matrix-assisted-laser-desorption-ionization-mass-spectrometry-imaging
#15
Florian P Y Barré, Bryn Flinders, João P Garcia, Imke Jansen, Lennart R S Huizing, Tiffany Porta, Laura B Creemers, Ron M A Heeren, Berta Cillero-Pastor
Osteoarthritis (OA), characterized by degeneration of the cartilaginous tissue in articular joints, severely impairs mobility in many people worldwide. The degeneration is thought to be mediated by inflammatory processes occurring in the tissue of the joint, including the cartilage. Intra-articular administered triamcinolone acetonide (TAA) is one of the drug treatments employed to ameliorate the inflammation and pain that characterizes OA. However, the penetration and distribution of TAA into the avascular cartilage is not well understood...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28188487/management-and-radiographic-outcomes-of-femoral-head-fractures
#16
John A Scolaro, Geoffrey Marecek, Reza Firoozabadi, James C Krieg, Milton Lee Chip Routt
BACKGROUND: Femoral head fractures are uncommon injuries. Small series constitute the majority of the available literature. Surgical approach and fracture management is variable. The purpose of this study was to evaluate the incidence, method of treatment, and outcomes of consecutive femoral head fractures at a regional academic Level I trauma center. MATERIALS AND METHODS: A retrospective review of a prospective database was performed over a 13-year period. All AO/OTA 31C femoral head fractures were identified...
February 10, 2017: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/28187745/a-systematic-review-of-undisplaced-femoral-neck-fracture-treatments-for-patients-over-65%C3%A2-years-of-age-with-a-focus-on-union-rates-and-avascular-necrosis
#17
Dan-Feng Xu, Fang-Gang Bi, Chi-Yuan Ma, Zheng-Fa Wen, Xun-Zi Cai
BACKGROUND: It remains unclear whether conservative treatment should be used to treat the common undisplaced femoral neck fractures that develop in the elderly. Herein, we systematically review the rates of union and avascular necrosis after conservative and surgical treatment of undisplaced femoral neck fractures. METHODS: We searched the EMBASE, PubMed, OVID, Cochrane Library, Web of Science, and Scopus databases for randomized controlled trials or observational studies that assessed the outcomes of conservative or surgical treatments of undisplaced femoral neck fractures...
February 10, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28186682/repair-of-torn-avascular-meniscal-cartilage-using-undifferentiated-autologous-mesenchymal-stem-cells-from-in-vitro-optimization-to-a-first-in-human-study
#18
Michael R Whitehouse, Nicholas R Howells, Michael C Parry, Eric Austin, Wael Kafienah, Kyla Brady, Allen E Goodship, Jonathan D Eldridge, Ashley W Blom, Anthony P Hollander
Meniscal cartilage tears are common and predispose to osteoarthritis (OA). Most occur in the avascular portion of the meniscus where current repair techniques usually fail. We described previously the use of undifferentiated autologous mesenchymal stem cells (MSCs) seeded onto a collagen scaffold (MSC/collagen-scaffold) to integrate meniscal tissues in vitro. Our objective was to translate this method into a cell therapy for patients with torn meniscus, with the long-term goal of delaying or preventing the onset of OA...
December 15, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28184362/uncemented-total-hip-replacement-after-two-years-of-neglected-hip-dislocation-with-fracture-of-posterior-column-and-wall-of-the-acetabulum
#19
Sundaresh Dc, Sharath K Ramanath, Amit Grover, Daksh Gadi
INTRODUCTION: Posterior hip dislocation of the hip with acetabular fracture is a challenging problem to treat. Such dislocations are associated with avascular necrosis of the femoral head if neglected. Managing such conditions with total hip replacement (THR) is very difficult because of associated altered anatomy. CASE PRESENTATION: We hereby report a two-year neglected hip dislocation with associated acetabular fracture successfully treated with uncemented THR...
November 2016: Trauma Monthly
https://www.readbyqxmd.com/read/28182595/treatment-of-advanced-kienb%C3%A3-ck-disease-with-a-vascularized-radial-bone-flap-wrapped-in-the-pronator-quadratus
#20
Sang Ki Lee, Kap Jung Kim, Hyuck Soo Shin, Won Sik Choy
PURPOSE: In the present study, we aimed to assess the radiologic and clinical outcomes after excision of the lunate, insertion of a vascularized radial bone flap wrapped in the pronator quadratus, and distraction with an external fixator of the joint, for the treatment of avascular necrosis of the lunate with carpal height collapse, fragmentation, and perilunar osteoarthritic changes. MATERIALS AND METHODS: From May 2006 to July 2014, a total of 25 patients (13 men and 12 women; mean age, 38...
March 2017: Annals of Plastic Surgery
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