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https://www.readbyqxmd.com/read/28636206/retinal-vascular-injuries-and-intravitreal-human-embryonic-stem-cell-derived-haemangioblasts
#1
Jin-Da Wang, Ying An, Jing-Shang Zhang, Xiu-Hua Wan, Wei Zhang, Robert Lanza, Shi-Jiang Lu, Jost B Jonas, Liang Xu
OBJECTIVE: To investigate whether intravitreally applied haemangioblasts (HB) derived from human embryonic stem cells (hESCs) are helpful for the repair of vascular damage caused in animals by an oxygen-induced retinopathy (OIR), by an induced diabetic retinopathy (DR) or by an induced retinal ischaemia with subsequent reperfusion. METHODS: Human embryonic stem cell-derived HBs were transplanted intravitreally into C57BL/6J mice (OIR model), into male Wistar rats with an induced DR and into male Wistar rats undergoing induced retinal ischaemia with subsequent reperfusion...
June 21, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28634350/a-subset-of-cerebrovascular-pericytes-originates-from-mature-macrophages-in-the-very-early-phase-of-vascular-development-in-cns
#2
Seiji Yamamoto, Masashi Muramatsu, Erika Azuma, Masashi Ikutani, Yoshinori Nagai, Hiroshi Sagara, Bon-Nyeo Koo, Satomi Kita, Erin O'Donnell, Tsuyoshi Osawa, Hiroyuki Takahashi, Ken-Ichi Takano, Mitsuko Dohmoto, Michiya Sugimori, Isao Usui, Yasuhide Watanabe, Noboru Hatakeyama, Takahiro Iwamoto, Issei Komuro, Kiyoshi Takatsu, Kazuyuki Tobe, Shumpei Niida, Naoyuki Matsuda, Masabumi Shibuya, Masakiyo Sasahara
Pericytes are believed to originate from either mesenchymal or neural crest cells. It has recently been reported that pericytes play important roles in the central nervous system (CNS) by regulating blood-brain barrier homeostasis and blood flow at the capillary level. However, the origin of CNS microvascular pericytes and the mechanism of their recruitment remain unknown. Here, we show a new source of cerebrovascular pericytes during neurogenesis. In the CNS of embryonic day 10.5 mouse embryos, CD31(+)F4/80(+) hematopoietic lineage cells were observed in the avascular region around the dorsal midline of the developing midbrain...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28633801/total-talar-prosthesis-replacement-after-talar-extrusion
#3
Sébastien Ruatti, Clémentine Corbet, Mehdi Boudissa, Gael Kerschbaumer, Michel Milaire, Philippe Merloz, Jérôme Tonetti
Dislocation of the talus is a serious and extremely rare injury, with 86 cases reported in the published data in 20 years. The reference standard for case management involves replacement of the dislocated talus to restore the height and function of the tibiotalar joint. The risk of avascular necrosis remains very high, and the standard treatment in such cases is tibiotalar arthrodesis. We report the case of total dislocation of the talus, which was treated with the insertion of a custom total talar prosthesis affixed directly to the tibial cartilage at 6 months after injury...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28633784/complications-of-talar-neck-fractures-by-hawkins-classification-a%C3%A2-systematic-review
#4
REVIEW
Richard K Jordan, Kunaal R Bafna, Jiayong Liu, Nabil A Ebraheim
The goal of the present study was to perform a systematic review of the published data on talar neck fractures for a better understanding of the postoperative clinical outcomes using open reduction and internal fixation stratified by Hawkins type. A PubMed search was performed using the keywords "talar," "neck," and "fracture." This search identified 209 potential studies, which were reviewed to yield 16 studies that met the criteria. The surgical outcomes of talar neck fractures stratified by the Hawkins classification analyzed in the present study were as follows: American Orthopaedic Foot and Ankle Society scale score was 77...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28631889/microrna-containing-extracellular-vesicles-released-from-endothelial-colony-forming-cells-modulate-angiogenesis-during-ischaemic-retinopathy
#5
Margaret Dellett, Eoin D Brown, Jasenka Guduric-Fuchs, Anna O'Connor, Alan W Stitt, Reinhold J Medina, David A Simpson
Endothelial colony-forming cells (ECFCs) are a defined subtype of endothelial progenitors that modulate vascular repair and promote perfusion in ischaemic tissues. Their paracrine activity on resident vasculature is ill-defined, but mediated, at least in part, by the transfer of extracellular vesicles (EVs). To evaluate the potential of isolated EVs to provide an alternative to cell-based therapies, we first performed a physical and molecular characterization of those released by ECFCs. Their effects upon endothelial cells in vitro and angiogenesis in vivo in a model of proliferative retinopathy were assessed...
June 20, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28629558/is-there-a-trend-in-ct-scanning-scaphoid-nonunions-for-deformity-assessment-a-systematic-review
#6
REVIEW
Paul W L Ten Berg, Marieke G A de Roo, Mario Maas, Simon D Strackee
PURPOSE: The effect of scaphoid nonunion deformity on wrist function is uncertain due to the lack of reliable imaging tools. Advanced three-dimensional (3-D) computed tomography (CT)-based imaging techniques may improve deformity assessment by using a mirrored image of the contralateral intact wrist as anatomic reference. The implementation of such techniques depends on the extent to which conventional CT is currently used in standard practice. The purpose of this systematic review of medical literature was to analyze the trend in CT scanning scaphoid nonunions, either unilaterally or bilaterally...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28629385/administrative-algorithms-to-identify-avascular-necrosis-of-bone-among-patients-undergoing-upper-or-lower-extremity-magnetic-resonance-imaging-a-validation-study
#7
Medha Barbhaiya, Yan Dong, Jeffrey A Sparks, Elena Losina, Karen H Costenbader, Jeffrey N Katz
BACKGROUND: Studies of the epidemiology and outcomes of avascular necrosis (AVN) require accurate case-finding methods. The aim of this study was to evaluate performance characteristics of a claims-based algorithm designed to identify AVN cases in administrative data. METHODS: Using a centralized patient registry from a US academic medical center, we identified all adults aged ≥18 years who underwent magnetic resonance imaging (MRI) of an upper/lower extremity joint during the 1...
June 19, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28628420/value-of-multiparametric-us-in-the-assessment-of-intratesticular-lesions
#8
Thomas Auer, Tobias De Zordo, Christian Dejaco, Leonhard Gruber, Renate Pichler, Werner Jaschke, Vikram S Dogra, Friedrich Aigner
Purpose To evaluate the diagnostic accuracy of multiparametric ultrasonography (US) consisting of gray-scale US, color Doppler US, strain elastography, and contrast agent-enhanced US in the assessment of intratesticular lesions. Materials and Methods Institutional review board approval was obtained for this retrospective study. From January 2012 to December 2015, 55 focal testicular lesions that were indeterminate on gray-scale US scans were further characterized with color Doppler US, strain elastography, and contrast-enhanced US...
June 16, 2017: Radiology
https://www.readbyqxmd.com/read/28626591/a-case-of-trapezium-avascular-necrosis-treated-conservatively
#9
Evangelos Petsatodis, Konstantinos Ditsios, Panagiotis Konstantinou, Iosafat Pinto, Lazaros Kostretzis, Ioannis Theodoroudis, Mayia Pilavaki
INTRODUCTION: Avascular necrosis (AVN) of the bones of the wrist most commonly involves the lunate followed by the proximal pole of the scaphoid and the capitate. Trapezium avascular necrosis is extremely rare with only two cases reported in the literature, both of which were treated surgically. In this article, we report a unique case of trapezium avascular necrosis treated conservatively. CASE PRESENTATION: A 38-year-old man complaining of a 4-month history of mild pain on the base of his right thumb...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28623409/evaluation-of-bone-viability-in-patients-after-girdlestone-arthroplasty-comparison-of-bone-spect-ct-and-mri
#10
G Diederichs, P Hoppe, F Collettini, G Wassilew, B Hamm, W Brenner, M R Makowski
PURPOSE: To test the diagnostic performance of bone SPECT/CT and MRI for the evaluation of bone viability in patients after girdlestone-arthroplasty with histopathology used as gold standard. MATERIALS AND METHODS: In this cross-sectional study, patients after girdlestone-arthroplasty were imaged with single-photon-emission-computed-tomography/computed-tomography (SPECT/CT) bone-scans using 99mTc-DPD. Additionally, 1.5 T MRI was performed with turbo-inversion-recovery-magnitude (TIRM), contrast-enhanced T1-fat sat (FS) and T1-mapping...
June 16, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28622398/axial-length-variation-impacts-on-superficial-retinal-vessel-density-and-foveal-avascular-zone-area-measurements-using-optical-coherence-tomography-angiography
#11
Danuta M Sampson, Peijun Gong, Di An, Moreno Menghini, Alex Hansen, David A Mackey, David D Sampson, Fred K Chen
Purpose: To evaluate the impact of image magnification correction on superficial retinal vessel density (SRVD) and foveal avascular zone area (FAZA) measurements using optical coherence tomography angiography (OCTA). Methods: Participants with healthy retinas were recruited for ocular biometry, refraction, and RTVue XR Avanti OCTA imaging with the 3 × 3-mm protocol. The foveal and parafoveal SRVD and FAZA were quantified with custom software before and after correction for magnification error using the Littman and the modified Bennett formulae...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28619441/radiologic-guide-to-surgical-treatment-of-kienbock-s-disease
#12
REVIEW
Erika M Nealey, Jonelle M Petscavage-Thomas, Felix S Chew, Christopher H Allan, Alice S Ha
Kienbock's disease, or avascular necrosis of the lunate, is a progressive disease ultimately resulting in end-stage arthrosis of the wrist. Various surgical treatments are available for different Lichtman stages of disease. We review the surgical options and indications, expected radiologic post-operative appearance, as well as detail potential surgical complications, as they relate to Kienbock's disease.
April 25, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28619244/impact-of-avascular-areas-as-measured-by-contrast-enhanced-harmonic-eus-on-the-accuracy-of-fine-needle-aspiration-for-pancreatic-adenocarcinoma
#13
Ken Kamata, Mamoru Takenaka, Shunsuke Omoto, Takeshi Miyata, Kosuke Minaga, Kentaro Yamao, Hajime Imai, Toshiharu Sakurai, Naoshi Nishida, Takaaki Chikugo, Yasutaka Chiba, Ippei Matsumoto, Yoshifumi Takeyama, Masatoshi Kudo
BACKGROUND AND AIMS: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is used for the diagnosis of pancreatic adenocarcinoma, but sometimes the method results in a false negative. Occasionally, an avascular area may be observed within the pancreatic adenocarcinoma tumor during contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS). The aim of this study was to evaluate whether the diagnostic sensitivity of EUS-FNA for pancreatic adenocarcinoma was affected by the presence of avascularity on CH-EUS...
June 12, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28616362/assessing-the-accuracy-of-foveal-avascular-zone-measurements-using-optical-coherence-tomography-angiography-segmentation-and-scaling
#14
Rachel Linderman, Alexander E Salmon, Margaret Strampe, Madia Russillo, Jamil Khan, Joseph Carroll
PURPOSE: The foveal avascular zone (FAZ) is altered in numerous diseases. We assessed factors (axial length, segmentation method, age, sex) impacting FAZ measurements from optical coherence tomography (OCT) angiography images. METHODS: We recruited 116 Caucasian subjects without ocular disease, and acquired two 3 × 3 mm AngioVue scans per each right eye (232 total scans). In images of the superficial plexus, the FAZ was segmented using the AngioVue semiautomatic nonflow measurement tool and ImageJ manual segmentation...
June 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28615510/formation-function-and-exhaustion-of-notochordal-cytoplasmic-vacuoles-within-intervertebral-disc-current-understanding-and-speculation
#15
REVIEW
Feng Wang, Zeng-Xin Gao, Feng Cai, Arjun Sinkemani, Zhi-Yang Xie, Rui Shi, Ji-Nan Wei, Xiao-Tao Wu
Notochord nucleus pulposus cells are characteristic of containing abundant and giant cytoplasmic vacuoles. This review explores the embryonic formation, biological function, and postnatal exhaustion of notochord vacuoles, aiming to characterize the signal network transforming the vacuolated nucleus pulposus cells into the vacuole-less chondrocytic cells. Embryonically, the cytoplasmic vacuoles within vertebrate notochord originate from an evolutionarily conserved vacuolation process during neurulation, which may continue to provide mechanical and signal support in constructing a mammalian intervertebral disc...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28614653/microfluidics-enabled-bottom-up-engineering-of-3d-vascularized-tumor-for-drug-discovery
#16
Pranay Agarwal, Hai Wang, Mingrui Sun, Jiangsheng Xu, Shuting Zhao, Zhenguo Liu, Keith J Gooch, Yi Zhao, Xiongbin Lu, Xiaoming He
Development of high-fidelity 3D models to recapitulate the tumor microenvironment is essential for studying tumor biology and screening anticancer drugs. Here we report a method to engineer the 3D microenvironment of human tumor, by encapsulating cancer cells in the core of microcapsules with a hydrogel shell for miniaturized 3D culture to obtain avascular microtumors first. The microtumors are then used as the building blocks for assembling with endothelial cells and other stromal cells to create macroscale 3D vascularized tumor...
June 14, 2017: ACS Nano
https://www.readbyqxmd.com/read/28614573/finite-element-modeling-of-avascular-tumor-growth-using-a-stress-driven-model
#17
Faezeh Iranmanesh, Mohammad Ali Nazari
Tumor growth being a multi-stage process has been investigated from different aspects. In the present study, an attempt is made to represent a constitutive-structure based model of avascular tumor growth in which the effects of tensile stresses caused by collagen fibers are considered. Collagen fibers as a source of anisotropy in the structure of tissue, is taken into account using a continuous fiber distribution formulation. To this end, a finite element modeling is implemented in which a neo-Hookean hyperelastic material is assigned to the tumor and its surrounding host...
June 14, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28613354/the-quantitative-measurements-of-vascular-density-and-flow-areas-of-macula-using-optical-coherence-tomography-angiography-in-normal-volunteers
#18
Fariba Ghassemi, Kaveh Fadakar, Fatemeh Bazvand, Reza Mirshahi, Masoumeh Mohebbi, Siamak Sabour
BACKGROUND AND OBJECTIVE: The quantification of the density of macular vascular networks and blood flow areas in the foveal and parafoveal area in healthy subjects using optical coherence tomography angiography (OCTA). PATIENTS AND METHODS: Cross-sectional, prospective study in an institutional setting at the Retina Services of Farabi Eye Hospital. One hundred twelve normal volunteers with no known ocular or systemic disease were included, including patient numbers (one or both eyes), selection procedures, inclusion/exclusion criteria, randomization procedure, and masking...
June 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28613219/repeatability-of-automated-vessel-density-and-superficial-and-deep-foveal-avascular-zone-area-measurements-using-optical-coherence-tomography-angiography-diurnal-findings
#19
Özge Yanik Odabaş, Sibel Demirel, Emin Özmert, Figen Batıoğlu
PURPOSE: To evaluate the repeatability of vessel density and superficial and deep foveal avascular zone measurements using optical coherence tomography angiography, and to specify a diurnal change range. METHODS: Forty-six eyes of 25 healthy individuals were included. Optical coherence tomography angiography measurements were planned for three consecutive sessions, with 3 hours in between them. AngioVue software of the RTVue XR Avanti was used. Superficial and deep retinal layer vessel density values, including the whole retina, fovea, and each parafoveal zone, were obtained from the software...
May 2, 2017: Retina
https://www.readbyqxmd.com/read/28612188/direct-quantification-of-solute-diffusivity-in-agarose-and-articular-cartilage-using-correlation-spectroscopy
#20
Janty S Shoga, Brian T Graham, Liyun Wang, Christopher Price
Articular cartilage is an avascular tissue; diffusive transport is critical for its homeostasis. While numerous techniques have been used to quantify diffusivity within porous, hydrated tissues and tissue engineered constructs, these techniques have suffered from issues regarding invasiveness and spatial resolution. In the present study, we implemented and compared two separate correlation spectroscopy techniques, fluorescence correlation spectroscopy (FCS) and raster image correlation spectroscopy (RICS), for the direct, and minimally-invasive quantification of fluorescent solute diffusion in agarose and articular cartilage...
June 13, 2017: Annals of Biomedical Engineering
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