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https://www.readbyqxmd.com/read/29154231/avascular-necrosis-of-femoral-condyles-in-a-patient-treated-due-to-lymphoma-a-case-study
#1
Kamil Graboń, Łukasz Paczesny, Jacek Kruczyński
Periarticular avascular osteonecrosis is one of the most severe joint diseases and may result in complete joint destruction. It may affect patients after chemotherapy involving regimens including steroids. The paper describes the case of a female patient who was just under 18 years old when she underwent surgery due to bilateral osteonecrosis of the femoral condyles that developed in the course of treatment of a haematological malignancy. The aim of the paper is to present clinical and imaging-based assessment of the outcome of surgical treatment by reconstruction of osteochondral joint defects with a collagen membrane and bone grafts...
October 31, 2017: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/29148018/lightbulb-technique-for-the-treatment-of-osteonecrosis-of-the-femoral-head
#2
Cemil Yildiz, Yusuf Erdem, Kenan Koca
INTRODUCTION: The aim of this study was to report the clinical and radiological outcomes for 21 patients (28 hips) treated for osteonecrosis of the femoral head using the lightbulb technique, a nonvascularised bone grafting technique. METHODS: The study group included 14 men and 7 women, with a mean age of 33.2 (range 22-50) years, presenting with avascular necrosis of the femoral head of stage 4a or earlier, according to the Steinberg classification. Patients were treated using the nonvascularised lightbulb bone grafting technique...
November 15, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29147820/cue-signal-response-analysis-in-3d-chondrocyte-scaffolds-with-anabolic-stimuli
#3
Michael Neidlin, Antonion Korcari, Giorgos Macheras, Leonidas G Alexopoulos
Articular cartilage is an avascular connective tissue responsible for bearing loads. Cell signaling plays a central role in cartilage homeostasis and tissue engineering by directing chondrocytes to synthesize/degrade the extracellular matrix or promote inflammatory responses. The aim of this paper was to investigate anabolic, catabolic and inflammatory pathways of well-known and underreported anabolic stimuli in 3D chondrocyte cultures and connect them to diverse cartilage responses including matrix regeneration and cell communication...
November 16, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29146169/arthroscopy-after-traumatic-hip-dislocation-a%C3%A2-systematic-review-of-intra-articular-findings-correlation-with-magnetic-resonance-imaging-and-computed-tomography-treatments-and-outcomes
#4
REVIEW
Jacob C Mandell, Richard A Marshall, Michael B Banffy, Bharti Khurana, Michael J Weaver
PURPOSE: To describe the literature concerning patient demographic characteristics and intra-articular injury seen at arthroscopy after traumatic hip dislocation, describe the reported computed tomography (CT) and magnetic resonance findings with arthroscopic correlation, and describe the reported arthroscopic treatments performed with complications and outcomes. METHODS: A systematic review was performed following Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines for assessment of arthroscopy after hip dislocation...
November 13, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29131775/traumatic-hip-dislocation-what-the-orthopedic-surgeon-wants-to-know
#5
Jacob C Mandell, Richard A Marshall, Michael J Weaver, Mitchel B Harris, Aaron D Sodickson, Bharti Khurana
Hip dislocation is an important orthopedic emergency usually seen in young patients who have experienced high-energy trauma, often resulting in significant long-term morbidity. Rapid identification and reduction is critical, as prolonged dislocation increases the risk of developing avascular necrosis of the femoral head, and posttraumatic osteoarthritis is a common complication, even in the absence of associated fractures. Identification and timely management of hip dislocation are highly dependent on imaging, both at presentation and after attempted reduction...
November 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29130113/long-term-results-of-closed-reduction-for-developmental-dislocation-of-the-hip-in-children-of-walking-age-under-eighteen-months-old
#6
Soo Min Cha, Hyun Dae Shin, Byung Kon Shin
BACKGROUND: Developmental dysplasia of the hip (DDH) diagnosed in older postnatal children can be effectively treated by closed reduction (CR) alone. However, no prospective or comparative trial to explore the differential effectiveness of CR between non-walking and walking postnatal children has yet been reported. This study investigated the clinical and radiologic outcomes of CR in the age range of interest (12-18 months old) via a prospective trial and compared these results with those of a younger age group who also underwent CR...
November 13, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29126401/dyslipidaemia-for-patients-with-low-energy-femoral-neck-fractures-after-the-treatment-of-cancellous-screws-a-retrospective-study-with-a-3-year-minimum-follow-up
#7
Chi Zhang, Xiaoxiao Zhu, Genwang Pei, Ping Xu, Xianshang Zeng, Lili Zhang, Nan Zhang, Dan Zeng, Lei Cao, Weiguang Yu, Xinchao Zhang
BACKGROUND: Avascular necrosis of the femoral head (AVNFH) occurs infrequently following femoral neck fracture. The association between AVNFH and dyslipidaemia remains controversial. Although major risk factors for AVNFH have been proposed, most of them remain under discussion. Our purpose herein was to evaluate the association between dyslipidaemia and AVNFH following low-energy femoral neck fractures treated with cancellous screws in elderly patients in our tertiary care centre. METHODS: Four hundred and seventy-two consecutive patients (472 hips) with low-energy femoral neck fractures were identified and treated with cancellous screws from July 2007 to April 2013...
November 10, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29125919/autologous-chondrocyte-implantation-sandwich-technique-compared-with-autologous-bone-grafting-for-deep-osteochondral-lesions-in-the-knee
#8
Tom Minas, Takahiro Ogura, Jeff Headrick, Tim Bryant
BACKGROUND: Treating symptomatic osteochondral defects is challenging, especially in young adults with deep (>8-10 mm) empty defects after osteochondritis dissecans (OCD) or collapsed condyles secondary to avascular necrosis (AVN). For this population, osteoarthritis (OA) is inevitable if articular congruence is not restored. PURPOSE: To describe the autologous chondrocyte implantation (ACI) "sandwich" technique with autologous bone grafting (ABG) and compare it with ABG alone for restoration of the osteochondral unit...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29121926/quantitative-and-qualitative-aspects-of-standing-up-behavior-and-the-prevalence-of-osteochondrosis-in-warmblood-foals-on-different-farms-could-there-be-a-link
#9
E M van Grevenhof, A R D Gezelle Meerburg, M C van Dierendonck, A J M van den Belt, B van Schaik, P Meeus, W Back
BACKGROUND: Osteochondrosis (OC) is a common, clinically important joint disorder in which endochondral ossification is focally disturbed. Reduced blood supply to growing cartilage is considered an important cause of the condition, which has both genetic and environmental origins. Housing conditions can influence cartilage injury through peak-pressure changes during limb sliding. Additionally, circulatory perturbation can cause the avascular necrosis of cartilage. In this study, we evaluated the type and frequency of limb sliding during standing up and the occurrence of OC in foals aged up to 12 months on different farms...
November 9, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29121417/transabdominal-cerclage-tac-for-patients-with-ultra-short-uterine-cervix-after-uterine-cervix-surgery-and-its-impact-on-pregnancy
#10
Shinichi Ishioka, Miseon Kim, Yuko Mizugaki, Saori Kon, Kyoko Isoyama, Masahito Mizuuchi, Miyuki Morishita, Tsuyoshi Baba, Takao Sekiya, Tsuyoshi Saito
AIM: Patients with an ultra-short uterine cervix as a result of large conization, repeated conization or radical trachelectomy (RT), are at high risk of preterm premature rupture of the membrane, which leads to preterm birth. We have commenced performing transabdominal cerclage (TAC) of the uterine cervix for these patients. In this study, we examined the safety of TAC and its impact on pregnancy. METHODS: We have performed TAC in 11 patients before pregnancy: in six after large cervical operations, such as repeated conization; and in five for difficulties with cervical cerclage after RT...
November 9, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29121140/complications-of-cosmetic-eye-whitening
#11
Ann Q Tran, Catherine Hoppener, Nandini Venkateswaran, Daniel S Choi, Wendy W Lee
Introduced in 2008 and subsequently popularized in South Korea, cosmetic eye whitening has been offered as a treatment of chronic conjunctival hyperemia. Patients undergo conjunctivectomy with topical mitomycin C (MMC) 0.02% application to achieve a whitened appearance from bleaching of avascular sclera. Much speculation has arisen from this procedure given the limited available evidence on its efficacy and safety. A literature search was performed to review common complications of cosmetic eye whitening, including chronic conjunctival epithelial defects, scleral thinning, avascular zones in the sclera, dry eye syndrome, and diplopia requiring strabismus surgery...
September 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29118510/foveal-neovascularization-in-a-patient-with-type-2-diabetes-mellitus
#12
Anisha Seth, Basudeb Ghosh, Vishaal Bhambhwani, Anika Gupta, Usha K Raina
Retinal neovascularization in Diabetes mellitus (DM) is commonly seen at the optic disc and mid-periphery. It is rare at the fovea as the fovea is an avascular zone and there are very few case reports of foveal neovascularization in Type 1 DM. We report a case of unilateral foveal neovascularization in Type 2 DM.
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29117211/the-treatment-of-femoral-neck-fracture-using-vegf-loaded-nanographene-coated-internal-fixation-screws
#13
Shuo Li, Hengfeng Yuan, Jianfeng Pan, Wenshuai Fan, Liang Zhu, Zuoqin Yan, Changan Guo
PURPOSE: Previous studies have proved that vascular endothelial growth factor (VEGF) has a dual role in the promotion of new bone formation and blood vessel repair during fracture healing. However, how to introduce VEGF to a fracture site safely and effectively is still a challenge. This study aimed to prepare a VEGF-loaded nanographene coated internal fixation screw and to evaluate its effects in the treatment of femoral neck fracture. METHODS: Nanographene coated screws were prepared by direct liquid-phase exfoliation of the graphite method, and the surface characteristics were observed through scanning electron microscopy (SEM)...
2017: PloS One
https://www.readbyqxmd.com/read/29116358/humeral-head-inferior-subluxation-in-proximal-humerus-fractures
#14
Stefano Carbone, Matteo Papalia, Valerio Arceri, Stefano Placidi, Andrea Carbone, Riccardo Mezzoprete
PURPOSE: The objectives of this study are to propose a reliable radiologic method for detecting static inferior subluxation of humeral head, to calculate the relative intra- and inter-observer reliability, and to evaluate its presence pre- and post-surgery. METHODS: This is a retrospective observational study of patients surgically treated for a fracture of the proximal humerus. Fractures were classified using Codman-Lego criteria (radiographic, CT images), osteoporosis was assessed...
November 7, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29115654/management-of-capitellar-fractures-with-open-reduction-and-internal-fixation-using-herbert-screws
#15
Asif Sultan, Omar Khursheed, Mohammad Rafiq Bhat, Hilal Ahmad Kotwal, Qazi Waris Manzoor
BACKGROUND: Capitellar fractures are rare elbow injuries and can cause severe limitation of function if not properly managed. Numerous treatments have evolved, from closed reduction and cast immobilization to open reduction and internal fixation (ORIF), so as to achieve a stable joint that allows early mobilization. We determined the functional outcomes of treating these fractures with ORIF using Herbert screws via an extensile lateral approach. METHODS: Fifteen patients with capitellar fractures were included in this retrospective study...
November 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29115490/microrna%C3%A2-206-contributes-to-the-progression-of-steroid%C3%A2-induced-avascular-necrosis-of-the-femoral-head-by-inducing-osteoblast-apoptosis-by-suppressing-programmed-cell-death-4
#16
Zaiheng Zhang, Anmin Jin, Denglu Yan
The expression of microRNA‑206 (miR‑206) is aberrantly induced in steroid‑induced avascular necrosis of femoral head (SANFH). Therefore, investigating the function of miR‑206 in SANFH and uncovering the functional mechanism associated with the condition will promote the understanding and treatment of the disease. The purpose of the present study was to investigate the pro‑osteoclasteogenic effect of miR‑206 that occurs through regulation of programmed cell death 4 (PDCD4). The expression of miR‑206 and PDCD4 was analyzed in the clinical SANFH specimens...
November 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29114187/use-of-fibular-bone-graft-and-cancellous-screw-fixation-in-the-management-of-neglected-femur-neck-fractures-in-young-patients
#17
Ghulam Mustafa Kaim Khani, Kamran Hafeez, Muhammad Bux, Nusrat Rasheed, Naveed Ahmed, M Perwez Anjum
Objective: To present the clinical outcome of patients with neglected femur neck fracture treated with fibular bone graft. Methods: During May 2010-February 2013, 15 patients younger than 35 years of age with neglected fracture neck of femur were managed with non-vascularized fibular graft and cannulated screws. Fractures were classified according to Sandhu Classification. Hip function was assessed using Harris hip score. Results: Fifteen patients with mean age of 28...
November 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29110176/avascular-necrosis-after-long-term-glucocorticoid-treatment-in-melas-a-cautionary-note
#18
Han Som Choi, Jae Hyun Lee, Sun Ho Lee, Young-Mock Lee
No abstract text is available yet for this article.
November 6, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29106948/good-functional-outcome-but-not-regained-health-related-quality-of-life-in-the-majority-of-20-69-years-old-patients-with-femoral-neck-fracture-treated-with-internal-fixation-a-prospective-2-year-follow-up-study-of-182-patients
#19
Pierre Campenfeldt, Margareta Hedström, Wilhelmina Ekström, Amer N Al-Ani
BACKGROUND AND PURPOSE: Prospective studies on patient related outcome in patients <70years with a femoral neck fracture (FNF) are few. We aimed to investigate functional outcome and health-related quality of life (HRQoL) in 20-69years old patients with a FNF treated with internal fixation. PATIENTS AND METHODS: 182 patients, 20-69years with a FNF treated with internal fixation were prospectively included in a multicenter study. Follow up included radiographic and clinical examination at 4, 12 and 24 months...
October 18, 2017: Injury
https://www.readbyqxmd.com/read/29105637/detection-of-ad-bmp-2-ires-hif-1%C3%AE-mu-on-local-promoting-angiogenic-and-osteogenic-capacity-of-necrosis-area
#20
Fuai Cui, Xiuli Wang, Wei Wang, Peng Xiao, Yuan Ma, Lindong Jiang
The induced EPCs were transfected by Ad-BMP-2-IRES-HIF-1αmu, and then transplanted into femoral head necrotic zone, the effect on osteogenesis and agiogenesis of necrosis zone was detected. The Ad-BMP-2-IRES-HIF-1α was transfected into induced EPCs and then transplanted into avascular necrotic parts of the femoral head (ANFH).Afterwards, the promotion effect on angiogenic and osteogenic capabilities of the necrosis parts from Ad-BMP-2-IRES-HIF-1α was detected. Rabbit bone marrow MNCs were obtained by density gradient centrifugation method, and were induced into EPCs by M199 medium; EPCs were identified in accordance with the cell morphology, specific surface markers and uptake abilities...
September 2017: Pakistan Journal of Pharmaceutical Sciences
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