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https://www.readbyqxmd.com/read/28343944/rack1-cooperates-with-nras-q61k-to-promote-melanoma-in-vivo
#1
C Campagne, E Reyes-Gomez, M E Picco, S Loiodice, P Salaun, J Ezagal, F Bernex, P H Commère, S Pons, D Esquerre, E Bourneuf, J Estellé, U Maskos, P Lopez-Bergami, G Aubin-Houzelstein, J J Panthier, G Egidy
Melanoma is the deadliest skin cancer. RACK1 (Receptor for activated protein kinase C) protein was proposed as a biological marker of melanoma in human and domestic animal species harboring spontaneous melanomas. As a scaffold protein, RACK1 is able to coordinate the interaction of key signaling molecules implicated in both physiological cellular functions and tumorigenesis. A role for RACK1 in rewiring ERK and JNK signaling pathways in melanoma cell lines had been proposed. Here, we used a genetic approach to test this hypothesis in vivo in the mouse...
March 23, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28339360/critical-role-of-stir-mri-in-early-detection-of-post-streptococcal-periostitis-with-dysproteinaemia-goldbloom-s-syndrome
#2
Riccardo Papa, Alessandro Consolaro, Francesca Minoia, Roberta Caorsi, Gianmichele Magnano, Marco Gattorno, Angelo Ravelli, Paolo Picco
OBJECTIVES: In 1966, Goldbloom et al. described two children who developed a peculiar clinical picture characterized by intermittent daily bone pain in the lower limbs, fever spikes, increased acute phase reactants and dysproteinaemia. The syndrome occurred two weeks after a group A β-haemolytic streptococcus infection. So far, only a few cases have been reported in the medical literature in English. METHODS: We report two further cases of Goldbloom's syndrome with a review of the literature in English...
March 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28317651/clinical-validity-of-presynaptic-dopaminergic-imaging-with%C3%A2-123-i-ioflupane%C3%A2-and-noradrenergic-imaging-with-123-i-mibg-in-the-differential-diagnosis-between-alzheimer-s-disease-and-dementia-with-lewy-bodies-in-the-context-of-a-structured-5-phase-development
#3
REVIEW
Ida Sonni, Osman Ratib, Marina Boccardi, Agnese Picco, Karl Herholz, Flavio Nobili, Andrea Varrone
The use of biomarkers (BMs) for accurate diagnosis of Alzheimer's disease (AD) has been proposed by recent diagnostic criteria; however, their maturity is not sufficient to grant implementation in the clinical routine. A proper diagnostic process requires not only confirmation of the disease but also the exclusion of similar disorders entering differential diagnosis, like dementia with Lewy bodies (DLB). This review is aimed at evaluating the clinical validity of (123)I-ioflupane brain single photon emission tomography and (123)I-MIBG cardiac scintigraphy as imaging BMs for DLB...
April 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28317650/clinical-validity-of-increased-cortical-uptake-of-amyloid-ligands-on-pet-as-a-biomarker-for-alzheimer-s-disease-in-the-context-of-a-structured-5-phase-development-framework
#4
REVIEW
Konstantinos Chiotis, Laure Saint-Aubert, Marina Boccardi, Anton Gietl, Agnese Picco, Andrea Varrone, Valentina Garibotto, Karl Herholz, Flavio Nobili, Agneta Nordberg
The use of biomarkers has been proposed for diagnosing Alzheimer's disease in recent criteria, but some biomarkers have not been sufficiently investigated to justify their routine clinical use. Here, we evaluate in a literature review the clinical validity of amyloid positron emission tomography (PET) imaging using a structured framework developed for the assessment of oncological biomarkers. Homogenous criteria have been addressed in reviews of other Alzheimer's disease biomarkers. There is adequate evidence that the main aims of phases 1 (rationale for use) and 2 (discriminative ability) have been achieved...
April 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28317648/clinical-validity-of-brain-fluorodeoxyglucose-positron-emission-tomography-as-a-biomarker-for-alzheimer-s-disease-in-the-context-of-a-structured-5-phase-development-framework
#5
REVIEW
Valentina Garibotto, Karl Herholz, Marina Boccardi, Agnese Picco, Andrea Varrone, Agneta Nordberg, Flavio Nobili, Osman Ratib
The use of Alzheimer's disease (AD) biomarkers is supported in diagnostic criteria, but their maturity for clinical routine is still debated. Here, we evaluate brain fluorodeoxyglucose positron emission tomography (FDG PET), a measure of cerebral glucose metabolism, as a biomarker to identify clinical and prodromal AD according to the framework suggested for biomarkers in oncology, using homogenous criteria with other biomarkers addressed in parallel reviews. FDG PET has fully achieved phase 1 (rational for use) and most of phase 2 (ability to discriminate AD subjects from healthy controls or other forms of dementia) aims...
April 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28297910/coarsening-and-percolation-in-a-disordered-ferromagnet
#6
Federico Corberi, Leticia F Cugliandolo, Ferdinando Insalata, Marco Picco
By studying numerically the phase-ordering kinetics of a two-dimensional ferromagnetic Ising model with quenched disorder (either random bonds or random fields) we show that a critical percolation structure forms at an early stage. This structure is then rendered more and more compact by the ensuing coarsening process. Our results are compared to the nondisordered case, where a similar phenomenon is observed, and they are interpreted within a dynamical scaling framework.
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28268881/a-comparison-between-four-techniques-to-measure-cardiac-output
#7
A Pironet, P C Dauby, J G Chase, P Morimont, N Janssen, B Lambermont, S Davidson, T Desaive
Cardiac output is an important variable when monitoring hemodynamic status. In particular, changes in cardiac output represent the goal of several circulatory management therapies. Unfortunately, cardiac output is very difficult to estimate, either in experimental or clinical settings. The goal of this work is to compare four techniques to measure cardiac output: pressure-volume catheter, aortic flow probe, thermodilution, and the PiCCO monitor. These four techniques were simultaneously used during experiments of fluid and endotoxin administration on 7 pigs...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28263741/the-impact-of-automated-hippocampal-volumetry-on-diagnostic-confidence-in-patients-with-suspected-alzheimer-s-disease-an-eadc-study
#8
Paolo Bosco, Alberto Redolfi, Martina Bocchetta, Clarissa Ferrari, Anna Mega, Samantha Galluzzi, Mark Austin, Andrea Chincarini, D Louis Collins, Simon Duchesne, Bénédicte Maréchal, Alexis Roche, Francesco Sensi, Robin Wolz, Montserrat Alegret, Frederic Assal, Mircea Balasa, Christine Bastin, Anastasia Bougea, Derya Durusu Emek-Savaş, Sebastiaan Engelborghs, Timo Grimmer, Galina Grosu, Milica G Kramberger, Brian Lawlor, Gorana Mandic Stojmenovic, Mihaela Marinescu, Patrizia Mecocci, José Luis Molinuevo, Ricardo Morais, Ellis Niemantsverdriet, Flavio Nobili, Konstantinos Ntovas, Sarah O'Dwyer, George P Paraskevas, Luca Pelini, Agnese Picco, Eric Salmon, Isabel Santana, Oscar Sotolongo-Grau, Luiza Spiru, Elka Stefanova, Katarina Surlan Popovic, Magda Tsolaki, Görsev G Yener, Dina Zekry, Giovanni B Frisoni
INTRODUCTION: Hippocampal volume is a core biomarker of Alzheimer's disease (AD). However, its contribution over the standard diagnostic workup is unclear. METHODS: Three hundred fifty-six patients, under clinical evaluation for cognitive impairment, with suspected AD and Mini-Mental State Examination ≥20, were recruited across 17 European memory clinics. After the traditional diagnostic workup, diagnostic confidence of AD pathology (DCAD) was estimated by the physicians in charge...
March 3, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28247337/widening-the-heterogeneity-of-leigh-syndrome-clinical-biochemical-and-neuroradiologic-features-in-a-patient-harboring-a-ndufa10-mutation
#9
Francesca Minoia, Marta Bertamino, Paolo Picco, Mariasavina Severino, Andrea Rossi, Chiara Fiorillo, Carlo Minetti, Claudia Nesti, Filippo Maria Santorelli, Maja Di Rocco
Leigh syndrome (LS) is an early-onset progressive neurodegenerative disorder, characterized by a wide clinical and genetic heterogeneity, and is the most frequent disorder of mitochondrial energy production in children. Beside its great variability in clinical, biochemical, and genetic features, LS is pathologically uniformly characterized by multifocal bilateral and symmetric spongiform degeneration of the basal ganglia, brainstem, thalamus, cerebellum, spinal cord, and optic nerves. Isolated complex I deficiency is the most common defect identified in Leigh syndrome...
March 1, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28227080/a-comparison-between-four-techniques-to-measure-cardiac-output
#10
A Pironet, P C Dauby, J G Chase, P Morimont, N Janssen, B Lambermont, S Davidson, T Desaive, A Pironet, P C Dauby, J G Chase, P Morimont, N Janssen, B Lambermont, S Davidson, T Desaive, T Desaive, B Lambermont, P C Dauby, N Janssen, P Morimont, A Pironet, J G Chase, S Davidson
Cardiac output is an important variable when monitoring hemodynamic status. In particular, changes in cardiac output represent the goal of several circulatory management therapies. Unfortunately, cardiac output is very difficult to estimate, either in experimental or clinical settings. The goal of this work is to compare four techniques to measure cardiac output: pressure-volume catheter, aortic flow probe, thermodilution, and the PiCCO monitor. These four techniques were simultaneously used during experiments of fluid and endotoxin administration on 7 pigs...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28221358/ionic-solutions-of-two-dimensional-materials
#11
Patrick L Cullen, Kathleen M Cox, Mohammed K Bin Subhan, Loren Picco, Oliver D Payton, David J Buckley, Thomas S Miller, Stephen A Hodge, Neal T Skipper, Vasiliki Tileli, Christopher A Howard
Strategies for forming liquid dispersions of nanomaterials typically focus on retarding reaggregation, for example via surface modification, as opposed to promoting the thermodynamically driven dissolution common for molecule-sized species. Here we demonstrate the true dissolution of a wide range of important 2D nanomaterials by forming layered material salts that spontaneously dissolve in polar solvents yielding ionic solutions. The benign dissolution advantageously maintains the morphology of the starting material, is stable against reaggregation and can achieve solutions containing exclusively individualized monolayers...
March 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28219189/-effects-of-phentolamine-on-haemodynamics-of-patients-with-severe-sepsis
#12
W Yang, X B Li, Y Zhou, X M Mo
Objective: To explore the effects of phentolamine on hemodynamic of patients with severe sepsis . Methods: From January 2015 to August 2016, using random number table, 59 patients with severe sepsis were divided into research group and the control group by conventional treatment in Department of Emergency, the Second People's Hospital of Nanning City. The patients of the research group were given phentolamine injection. The CI, ITBVI, EVLWI, SVRI of the patients were monitored by PICCO on 6, 12, 24, 48, 72 h before and after treatment...
February 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28215339/precise-tracking-of-the-dynamics-of-multiple-proteins-in-endocytic-events
#13
A Picco, M Kaksonen
Endocytosis is a complex and dynamic process that involves dozens of different proteins to define the site of endocytosis, form a membrane invagination, and pinch off a membrane vesicle into the cytoplasm. Fluorescent light microscopy is a powerful tool to visualize the dynamic behaviors of the proteins taking part in the endocytic process. The resolution of light microscopy is, however, a serious limitation. Here, we detail a fluorescence microscope method that we have developed to visualize the dynamics of the clathrin-mediated endocytic protein machinery in yeast cells...
2017: Methods in Cell Biology
https://www.readbyqxmd.com/read/28208323/upper-and-lower-critical-decay-exponents-of-ising-ferromagnets-with-long-range-interaction
#14
Toshiki Horita, Hidemaro Suwa, Synge Todo
We investigate the universality class of the finite-temperature phase transition of the two-dimensional Ising model with the algebraically decaying ferromagnetic long-range interaction, J_{ij}=|r[over ⃗]_{i}-r[over ⃗]_{j}|^{-(d+σ)}, where d (=2) is the dimension of the system and σ is the decay exponent, by means of the order-N cluster-algorithm Monte Carlo method. In particular, we focus on the upper and lower critical decay exponents, the boundaries between the mean-field-universality, intermediate, and short-range-universality regimes...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28205080/assessment-of-cu-zn-edta-parenteral-toxicity-in-calves
#15
Luis Emilio Fazzio, Diana Esther Rosa, Sebastian Julio Picco, Guillermo Alberto Mattioli
Copper (Cu) parenteral administration is used in a beef cow-calf operations to prevent or correct Cu deficiency in bovines. At present, Zinc (Zn) salts have been incorporated to complement Cu antioxidant effect. A risk of hepatotoxicity generated by overdose is a negative consequence of injectable Cu application. Cu-Zn EDTA appears as an alternative; however, data about its toxicity is unknown. The aim of this study was to assess toxicity risk of different doses of Cu-Zn EDTA in calves. Thirty two Aberdeen Angus calves of 162 (±20) kg BW were assigned to 4 groups (n = 8), homogeneous in weight, sex, and age...
February 15, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28188408/cross-comparisons-of-trending-accuracies-of-continuous-cardiac-output-measurements-pulse-contour-analysis-bioreactance-and-pulmonary-artery-catheter
#16
Bouchra Lamia, Hyung Kook Kim, Donald A Severyn, Michael R Pinsky
We compared the similarity of cardiac-output (CO) estimates between available bolus thermodilution pulmonary-artery catheters (PAC), arterial pulse-contour analysis (LiDCOplus(™), FloTrac(™) and PiCCOplus(™)), and bioreactance (NICOM(™)). Repetitive simultaneous estimates of CO obtained from the above devices were compared in 21 cardiac-surgery patients during the first 2 h post-surgery. Mean and absolute values for CO across the devices were compared by ANOVA, Bland-Altman, Pearson moment, and linear-regression analyses...
February 10, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28162781/intra-articular-corticosteroids-versus-intra-articular-corticosteroids-plus-methotrexate-in-oligoarticular-juvenile-idiopathic-arthritis-a-multicentre-prospective-randomised-open-label-trial
#17
Angelo Ravelli, Sergio Davì, Giulia Bracciolini, Angela Pistorio, Alessandro Consolaro, Evert Hendrik Pieter van Dijkhuizen, Bianca Lattanzi, Giovanni Filocamo, Sara Verazza, Valeria Gerloni, Maurizio Gattinara, Irene Pontikaki, Antonella Insalaco, Fabrizio De Benedetti, Adele Civino, Giuseppe Presta, Luciana Breda, Valentina Marzetti, Serena Pastore, Silvia Magni-Manzoni, Maria Cristina Maggio, Franco Garofalo, Donato Rigante, Marco Gattorno, Clara Malattia, Paolo Picco, Stefania Viola, Stefano Lanni, Nicolino Ruperto, Alberto Martini
BACKGROUND: Little evidence-based information is available to guide the treatment of oligoarticular juvenile idiopathic arthritis. We aimed to investigate whether oral methotrexate increases the efficacy of intra-articular corticosteroid therapy. METHODS: We did this prospective, open-label, randomised trial at ten hospitals in Italy. Using a concealed computer-generated list, children younger than 18 years with oligoarticular-onset disease were randomly assigned (1:1) to intra-articular corticosteroids alone or in combination with oral methotrexate (15 mg/m(2); maximum 20 mg)...
February 2, 2017: Lancet
https://www.readbyqxmd.com/read/28129539/the-in%C3%A2-vivo-architecture-of-the-exocyst-provides-structural-basis-for-exocytosis
#18
Andrea Picco, Ibai Irastorza-Azcarate, Tanja Specht, Dominik Böke, Irene Pazos, Anne-Sophie Rivier-Cordey, Damien P Devos, Marko Kaksonen, Oriol Gallego
The structural characterization of protein complexes in their native environment is challenging but crucial for understanding the mechanisms that mediate cellular processes. We developed an integrative approach to reconstruct the 3D architecture of protein complexes in vivo. We applied this approach to the exocyst, a hetero-octameric complex of unknown structure that is thought to tether secretory vesicles during exocytosis with a poorly understood mechanism. We engineered yeast cells to anchor the exocyst on defined landmarks and determined the position of its subunit termini at nanometer precision using fluorescence microscopy...
January 26, 2017: Cell
https://www.readbyqxmd.com/read/28113244/stem-cell-plasticity-and-niche-dynamics-in-cancer-progression
#19
Noemi Picco, Robert A Gatenby, Alexander R A Anderson
OBJECTIVE: Cancer stem cells (CSCs) have been hypothesized to initiate and drive tumor growth and recurrence due to their self-renewal ability. If correct, this hypothesis implies that successful therapy must focus primarily on eradication of this CSC fraction. However, recent evidence suggests stemness is niche dependent and may represent one of many phenotypic states that can be accessed by many cancer genotypes when presented with specific environmental cues. A better understanding of the relationship of stemness to niche-related phenotypic plasticity could lead to alternative treatment strategies...
September 8, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28113098/gender-differences-in-positive-mental-health-among-individuals-with-schizophrenia
#20
Anitha Jeyagurunathan, Janhavi Ajit Vaingankar, Edimansyah Abdin, Rajeswari Sambasivam, Esmond Seow, Shirlene Pang, Louisa Picco, Siow Ann Chong, Mythily Subramaniam
OBJECTIVE: This article aims to investigate the gender differences in positive mental health among outpatients with schizophrenia. METHODS: 142 outpatients (aged 21-65 years) with schizophrenia spectrum disorders were recruited from a tertiary psychiatric hospital. They were administered the following instruments: The Positive Mental Health (PMH) instrument, Patient Health Questionnaire (PHQ)-8 and Generalized Anxiety Disorder (GAD)-7, and the Global Assessment of Functioning (GAF) scale...
January 12, 2017: Comprehensive Psychiatry
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