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Gabriele Picco, Consalvo Petti, Francesco Sassi, Katia Grillone, Giorgia Migliardi, Teresa Rossi, Claudio Isella, Federica Di Nicolantonio, Ivana Sarotto, Anna Sapino, Alberto Bardelli, Livio Trusolino, Andrea Bertotti, Enzo Medico
BACKGROUND: The NEDD8 conjugation pathway modulates the ubiquitination and activity of a wide range of intracellular proteins, and its blockade by pevonedistat is emerging as a promising therapeutic approach in various cancer settings. However, systematic characterization of pevonedistat efficacy in specific tumor types and definition of response predictors are still missing. METHODS: We investigated in vitro sensitivity to pevonedistat in 122 colorectal cancer (CRC) cell lines by an ATP-based proliferation assay and evaluated apoptosis and DNA content by flow cytometry...
February 2017: Journal of the National Cancer Institute
Elisa Tassano, Mariasavina Severino, Silvia Rosina, Riccardo Papa, Domenico Tortora, Giorgio Gimelli, Cristina Cuoco, Paolo Picco
BACKGROUND: Deletions of the long arm of chromosome 18 cause a common autosomal syndrome clinically characterized by a protean clinical phenotype. CASE PRESENTATION: We report on a 16-month-old male infant affected by fever attacks apparently unrelated with any infectious or inflammatory symptoms, growth retardation, bilateral vertical talus, congenital aural atresia, dysmorphisms, mild psychomotor delay, and peculiar neuroradiological features. Array-CGH analysis revealed one of the smallest 18q22...
2016: Molecular Cytogenetics
P M Kapoor, Vandana Bhardwaj, Amita Sharma, Usha Kiran
A reliable estimation of cardiac preload is helpful in the management of severe circulatory dysfunction. The estimation of cardiac preload has evolved from nuclear angiography, pulmonary artery catheterization to echocardiography, and transpulmonary thermodilution (TPTD). Global end-diastolic volume (GEDV) is the combined end-diastolic volumes of all the four cardiac chambers. GEDV has been demonstrated to be a reliable preload marker in comparison with traditionally used pulmonary artery catheter-derived pressure preload parameters...
October 2016: Annals of Cardiac Anaesthesia
Xiaoping Lin, Zhijun Xu, Pengfei Wang, Yan Xu, Gensheng Zhang
Neurogenic pulmonary edema (NPE) is occasionally observed in patients with traumatic brain injury (TBI); however, this condition is often underappreciated. NPE is frequently misdiagnosed due to its atypical clinical performance, thus delaying appropriate treatment. A comprehensive management protocol of NPE in patients with TBI has yet to be established. The current study reported the case of a 67-year-old man with severe TBI who was transferred to our intensive care unit (ICU). On day 7 after hospitalization, the patient suddenly suffered tachypnea, tachycardia, systemic hypertension and hypoxemia during lumbar cistern drainage...
October 2016: Experimental and Therapeutic Medicine
Edimansyah Abdin, Mythily Subramaniam, Louisa Picco, Shirlene Pang, Janhavi Ajit Vaingankar, Shazana Shahwan, Vathsala Sagayadevan, Yunjue Zhang, Siow Ann Chong
PURPOSE: The present study aims to examine the impact of chronic conditions after adjusting for differential item functioning (DIF) on the various aspects of health-related quality of life (HRQoL) in a multi-ethnic Asian population in Singapore. METHOD: Data on 3006 participants from a nation-wide cross-sectional survey of mental health literacy conducted in Singapore were used. Multiple Indicators Multiple Causes model was used to investigate the effects of chronic medical conditions on various HRQoL dimensions assessed with the 36-item Medical Outcomes Study Short Form Health Survey (SF-36) after adjusting for DIF...
September 27, 2016: Quality of Life Research
Noemi Picco, Robert A Gatenby, Alexander R A Anderson
OBJECTIVE: Cancer stem cells (CSCs) have been hypothesized to initiate and drive tumor growth and recurrence due to their self-renewal ability. If correct, this hypothesis implies that successful therapy must focus primarily on eradication of this CSC fraction. However, recent evidence suggests stemness is niche dependent and may represent one of many phenotypic states that can be accessed by many cancer genotypes when presented with specific environmental cues. A better understanding of the relationship of stemness to niche-related phenotypic plasticity could lead to alternative treatment strategies...
September 8, 2016: IEEE Transactions on Bio-medical Engineering
Richard Beatson, Virginia Tajadura-Ortega, Daniela Achkova, Gianfranco Picco, Theodora-Dorita Tsourouktsoglou, Sandra Klausing, Matthew Hillier, John Maher, Thomas Noll, Paul R Crocker, Joyce Taylor-Papadimitriou, Joy M Burchell
Siglec-9 is a sialic-acid-binding lectin expressed predominantly on myeloid cells. Aberrant glycosylation occurs in essentially all types of cancers and results in increased sialylation. Thus, when the mucin MUC1 is expressed on cancer cells, it is decorated by multiple short, sialylated O-linked glycans (MUC1-ST). Here we found that this cancer-specific MUC1 glycoform, through engagement of Siglec-9, 'educated' myeloid cells to release factors associated with determination of the tumor microenvironment and disease progression...
September 5, 2016: Nature Immunology
Janhavi Ajit Vaingankar, Siow Ann Chong, Edimansyah Abdin, Louisa Picco, Boon Yiang Chua, Saleha Shafie, Hui Lin Ong, Sherilyn Chang, Esmond Seow, Derrick Heng, Peak Chiang Chiam, Mythily Subramaniam
AIM: The present study examined the prevalence of frailty and its association with sociodemographic, clinical and social characteristics, and service utilization in a representative general population sample of Singaporean older adults. METHODS: A single-phase, cross-sectional survey was carried out in a nationally representative sample of 2102 Singapore residents aged 60 years and older. Five frailty parameters (weakness, slowness, exhaustion, low physical activity and/or unintentional weight loss) were measured to assess Fried's frailty phenotype to identify frail (meeting 3/5 criteria), prefrail (meeting 1 or 2 criteria) and non-frail (absence of all 5) older adults...
August 31, 2016: Geriatrics & Gerontology International
Louisa Picco, Mythily Subramaniam, Edimansyah Abdin, Janhavi Ajit Vaingankar, Siow Ann Chong
INTRODUCTION: Major depressive disorder (MDD) is one of the most common psychiatric disorders worldwide, and various sociodemographic risk factors including age, gender and ethnicity have been associated with MDD. The present study aimed to establish whether gender-specific differences relating to the prevalence and correlates of MDD existed in the Singapore adult resident population. METHODS: The Singapore Mental Health Study was a population-based, cross-sectional, epidemiological study among Singapore citizens and permanent residents aged 18 years and above...
August 16, 2016: Singapore Medical Journal
Bernhard Wernly, Michael Lichtenauer, Marcus Franz, Michael Fritzenwanger, Bjoern Kabisch, Hans-Reiner Figulla, Christian Jung
BACKGROUND: Heart failure is known to be a major public health problem. Fluid redistribution contributes to acute heart failure; therefore, knowledge of hemodynamic parameters could be important for optimizing outcomes. The pulse contour cardiac output monitor PiCCO uses the single thermal indicator technique and pulse contour analysis to calculate hemodynamic parameters of preload, afterload, cardiac output, systemic vascular resistance and extravascular lung water. OBJECTIVES: We primarily aimed to describe values and parameters seen in acute heart failure patients admitted to the intensive care unit (ICU) and secondly to investigate associations between hemodynamic measurements and survival data...
August 15, 2016: Wiener Klinische Wochenschrift
Louisa Picco, Edimansyah Abdin, Siow Ann Chong, Shirlene Pang, Janhavi A Vaingankar, Vathsala Sagayadevan, Kian Woon Kwok, Mythily Subramaniam
OBJECTIVE: This study investigated beliefs about help seeking, treatment options, and expected outcomes for alcohol abuse, dementia, depression, obsessive-compulsive disorder (OCD), and schizophrenia, by using a vignette-based approach. METHODS: The Mind Matters study was a comprehensive, population-based, cross-sectional survey conducted among Singapore residents (N=3,006) ages 18 to 65 to establish the level of mental health literacy. Questions were asked about whom the person in the vignette should seek help from, the likely helpfulness of a broad range of interventions, and the likely outcome for the person in the vignette with and without appropriate help...
August 15, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
Mithila Mahesh, Edimansyah Abdin, Janhavi Ajit Vaingankar, Louisa Picco, Anita Jeyagurunathan, Saleha Binte Shafie, Shirlene Pang, Vathsala Sagayadevan, Esmond Seow, Siow Ann Chong, Mythily Subramaniam
INTRODUCTION: Disability increases an individual's dependence and negatively impacts their physical, mental, and social functioning. The current study aims to establish the prevalence and risk factors of disability in Singapore's population. MATERIALS AND METHODS: Data was extracted from the Well-being of the Singapore Elderly (WiSE) study. This cross-sectional study recruited participants aged 60 years and above (n = 2421) who were representative of Singapore's multiethnic population...
July 2016: Annals of the Academy of Medicine, Singapore
Angela Albi, Ofer Pasternak, Ludovico Minati, Moira Marizzoni, David Bartrés-Faz, Núria Bargalló, Beatriz Bosch, Paolo Maria Rossini, Camillo Marra, Bernhard Müller, Ute Fiedler, Jens Wiltfang, Luca Roccatagliata, Agnese Picco, Flavio Mariano Nobili, Oliver Blin, Julien Sein, Jean-Philippe Ranjeva, Mira Didic, Stephanie Bombois, Renaud Lopes, Régis Bordet, Hélène Gros-Dagnac, Pierre Payoux, Giada Zoccatelli, Franco Alessandrini, Alberto Beltramello, Antonio Ferretti, Massimo Caulo, Marco Aiello, Carlo Cavaliere, Andrea Soricelli, Lucilla Parnetti, Roberto Tarducci, Piero Floridi, Magda Tsolaki, Manos Constantinidis, Antonios Drevelegas, Giovanni Frisoni, Jorge Jovicich
Free water elimination (FWE) in brain diffusion MRI has been shown to improve tissue specificity in human white matter characterization both in health and in disease. Relative to the classical diffusion tensor imaging (DTI) model, FWE is also expected to increase sensitivity to microstructural changes in longitudinal studies. However, it is not clear if these two models differ in their test-retest reproducibility. This study compares a bi-tensor model for FWE with DTI by extending a previous longitudinal-reproducibility 3T multisite study (10 sites, 7 different scanner models) of 50 healthy elderly participants (55-80 years old) scanned in two sessions at least 1 week apart...
August 13, 2016: Human Brain Mapping
A A Sychev, I A Savin, A S Goyachev, V D Tenedieva, A V Oshorov, A A Polupan, A G Gavrilov, A A Potapov
The aim of the study was to assess the significance of NT-proBNP levels as a predictor of the severity of patients' condition after severe TBI and critical stress of the heart. In this prospective observational study 118 patients admitted on 1-4 day after severe TBI (GCS <8 points on admission) was supervised. The average age of patients was 32 +/- 16 years, 28 women and 90 men were in this group. 12 of the observed patients died within the first 10 days. NT-proBNP level was determined by immunochemiluminescent analyzer "Immulite 2000" (Siemens)...
March 2016: Anesteziologiia i Reanimatologiia
Po-Yuan Shih, Wen-Ying Lin, Ming-Hui Hung, Ya-Jung Cheng, Kuang-Cheng Chan
BACKGROUND: This study compared the cardiac output (CO) obtained from PiCCO with that obtained from the noninvasive NICOM method. METHODS: Twenty-one cirrhotic patients receiving liver transplantation were enrolled. During the operation, their CO was measured by the PiCCO system via the thermodilution method as the standard and by the NICOM method. Two parameters including cardiac index (CI) and stroke volume index (SVI) were collected simultaneously at three phases during the surgery including the dissection phase (T1), the anhepatic phase (T2), and the reperfusion phase (T3)...
June 2016: Acta Anaesthesiologica Taiwanica: Official Journal of the Taiwan Society of Anesthesiologists
Marco Pagani, Alessandro Giuliani, Johanna Öberg, Andrea Chincarini, Silvia Morbelli, Andrea Brugnolo, Dario Arnaldi, Agnese Picco, Matteo Bauckneht, Ambra Buschiazzo, Gianmario Sambuceti, Flavio Nobili
The assessment of the degree of order of brain metabolism by means of a statistical mechanistic approach applied to FDG-PET, allowed us to characterize healthy subjects as well as patients with mild cognitive impairment and Alzheimer's Disease (AD). The intensity signals from 24 volumes of interest were submitted to principal component analysis (PCA) giving rise to a major first principal component whose eigenvalue was a reliable cumulative index of order. This index linearly decreased from 77 to 44% going from normal aging to AD patients with intermediate conditions between these values (r=0...
November 1, 2016: NeuroImage
Pratika Satghare, Siow Ann Chong, Janhavi Vaingankar, Louisa Picco, Edimansyah Abdin, Boon Yiang Chua, Mythily Subramaniam
Background. Although pain is experienced among people of all ages, there is a need to study its risk factors and impact among older adults. Aims. The study sought to determine the prevalence, sociodemographics, and clinical correlates of pain along with association of pain with disability among older adults in Singapore. Methods. The WiSE study was a comprehensive cross-sectional, single phase, epidemiological survey conducted among the elderly aged 60 years and above and used a nationally representative sample of three main ethnic groups in Singapore: Chinese, Malays, and Indians...
2016: Pain Research & Management: the Journal of the Canadian Pain Society
Weihua Zhu, Linjun Wan, Xiaohong Wan, Gang Wang, Meixian Su, Gengjin Liao, Qingqing Huang
OBJECTIVE: To investigate the accuracy and feasibility of brachial artery peak velocity variation (ΔVpeakbrach) and inferior vena cava variability (VIVC) as indicators of fluid responsiveness in critically ill patients. METHODS: A single-center prospective observation was conducted. The patients on mechanical ventilation with spontaneously breathing admitted to Department of Critical Care Medicine of the Second Affiliated Hospital of Kunming Medical University from June 2013 to August 2015 were enrolled...
August 2016: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Hong Mei, Miao Chen, Xiaoyun Fu, Kang Li, Guoyue Liu, Song Qin
OBJECTIVE: To investigate the influence of continuous veno-venous hemofiltration (CVVH) on cardiac output (CO) value and parameters of hemodynamics monitored by transpulmonary thermodilution technique in critical patients. METHODS: A prospective cohort study was conduced. Sixty-two critical patients admitted to intensive care unit (ICU) of Zunyi Medical College Affiliated Hospital from January 2011 to October 2015 were enrolled. All of the patients received CVVH through femoral vein puncture catheter...
August 2016: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Saleha Shafie, Shazana Shahwan, Edimansyah Abdin, Janhavi Vaingankar, Louisa Picco, Rajeswari Sambasivam, Yunjue Zhang, Li Ling Ng, Siow Ann Chong, Mythily Subramaniam
OBJECTIVES: This study aimed to identify socio-demographic correlates of slow gait speed among Singapore older adult residents and to examine the relationship between slow gait speed and the older adult residents' social network, physical health status, disability and mental health status. METHODS: Trained interviewers administered the adapted 10/66 research protocol through face-to-face interviews to 2565 respondents aged 60 and over. Information on gait test, socio-demographic characteristics, obesity, social network, physical status and activity, overall health, disability and mental health status were collected...
July 19, 2016: Aging & Mental Health
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