Michael I Meesters, Dennis Veerhoek, Fellery de Lange, Jacob-Willem de Vries, Jan R de Jong, Johannes W A Romijn, Hilde Kelchtermans, Dana Huskens, Robin van der Steeg, Pepijn W A Thomas, David T M Burtman, Laurentius J M van Barneveld, Alexander B A Vonk, Christa Boer
While experimental data state that protamine exerts intrinsic anticoagulation effects, protamine is still frequently overdosed for heparin neutralisation during cardiac surgery with cardiopulmonary bypass (CPB). Since comparative studies are lacking, we assessed the influence of two protamine-to-heparin dosing ratios on perioperative haemostasis and bleeding, and hypothesised that protamine overdosing impairs the coagulation status following cardiac surgery. In this open-label, multicentre, single-blinded, randomised controlled trial, patients undergoing on-pump coronary artery bypass graft surgery were assigned to a low (0...
August 1, 2016: Thrombosis and Haemostasis