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https://www.readbyqxmd.com/read/27911748/actions-of-steroids-new-neurotransmitters
#1
Lauren M Rudolph, Charlotte A Cornil, Melinda A Mittelman-Smith, Jennifer R Rainville, Luke Remage-Healey, Kevin Sinchak, Paul E Micevych
Over the past two decades, the classical understanding of steroid action has been updated to include rapid, membrane-initiated, neurotransmitter-like functions. While steroids were known to function on very short time spans to induce physiological and behavioral changes, the mechanisms by which these changes occur are now becoming more clear. In avian systems, rapid estradiol effects can be mediated via local alterations in aromatase activity, which precisely regulates the temporal and spatial availability of estrogens...
November 9, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27909653/magnetic-resonance-imaging-of-the-cervical-spine-under-represents-sagittal-plane-deformity-in-degenerative-myelopathy-patients
#2
Douglas S Weinberg, Arunit J Chugh, Jeremy J Gebhart, Jason D Eubanks
BACKGROUND: In treating patients with cervical myelopathy, surgical approach may be dictated by sagittal balance, highlighting the need for accurate pre-operative assessment. Magnetic Resonance Imaging (MRI) is widely-recognized for its utility in the diagnosis and surgical planning of cervical myelopathy. Plain radiographs (X-rays) are a reliable tool to assess bony alignment. However, they may not always be included in standard pre-operative evaluation, especially in an era of restricted payer-environments...
2016: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/27909651/hybrid-decompression-and-fixation-technique-for-the-treatment-of-multisegmental-cervical-spondylotic-myelopathy
#3
Barón Zárate-Kalfopulos, Walter Araos-Silva, Alejandro Reyes-Sánchez, Luis Miguel Rosales-Olivarez, Armando Alpizar-Aguirre, Francisco Lopez Melendez
BACKGROUND: Cervical spondilotic myelopathy (CSM) is defined as the compromise of the spinal cord due to degenerative changes of the cervical spine. It is the most common cause of spinal cord dysfunction in patients over 55 years. An early surgical management it is paramount to achieve better neurological outcome. There is still controversy regarding the appropriate surgical treatment for multisegmental CSM involving three or more levels. The hybrid decompression and fixation technique combines one or two level corpectomy and a single level discectomy in order to obtain optimum decompression and fixation in patients with multilevel cervical myelopathy...
2016: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/27906744/reliability-of-sagittal-spinopelvic-alignment-measurements-after-total-hip-arthroplasty
#4
Katri Pernaa, Matti Seppänen, Keijo Mäkelä, Mikhail Saltychev
STUDY DESIGN: This is a observational study. OBJECTIVE: To evaluate the reliability of measuring sagittal spinopelvic alignment after hip arthroplasty. SUMMARY OF BACKGROUND DATA: Pelvic incidence (PI), sacral slope (SS), pelvic tilt (PT), and lumbar lordosis (LL) are widely used in planning the treatment of people with spinal and hip disorders. Previously, these measures have proved reliable when hip heads are intact. Thus far, it is not known whether they are also reliable after total hip replacement...
November 30, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27902945/artificial-cervical-disc-replacement-with-the-prestige-lp-prosthesis-for-the-treatment-of-non-contiguous-2-level-cervical-degenerative-disc-disease-a-minimum-24-month-follow-up
#5
Tingkui Wu, Beiyu Wang, Chen Ding, Yang Meng, Jigang Lou, Yi Yang, Hao Liu
OBJECTIVE: We describe the features of non-contiguous 2-level cervical degenerative disc disease (NCDDD), investigate the safety and feasibility of artificial cervical disc replacement (ACDR) for the treatment of NCDDD, and expect that our study will provide spine surgeons with an alternative procedure for NCDDD. METHODS: Twenty-five patients with NCDDD received ACDR with a Prestige-LP prosthesis. Clinical outcomes were evaluated using the 36-Short Form (SF-36, Mental Component Summary [MCS] and Physical Component Summary [PCS]), Visual Analog Scale (VAS), Japanese Orthopedic Association (JOA), and Neck Disability Index (NDI) scores...
November 17, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27898600/is-it-necessary-to-extend-a-multilevel-posterior-cervical-decompression-and-fusion-to-the-upper-thoracic-spine
#6
Gregory D Schroeder, Christopher K Kepler, Mark F Kurd, Loren Mead, Paul W Millhouse, Priyanka Kumar, Kristen Nicholson, Christie Stawicki, Andrew Helber, Daniella Fasciano, Alpesh A Patel, Barret I Woods, Kris E Radcliff, Jeffery A Rihn, D Greg Anderson, Alan S Hilibrand, Alexander R Vaccaro
STUDY DESIGN: A retrospective cohort analysis. OBJECTIVE: The aim of this study was to determine if there is a difference in the revision rate in patients who undergo a multilevel posterior cervical fusions ending at C7, T1, or T2-T4. SUMMARY OF BACKGROUND DATA: Multilevel posterior cervical decompression and fusion is a common procedure for patients with cervical spondylotic myelopathy, but there is little literature available to help guide the surgeon in choosing the caudal level of a multilevel posterior cervical fusion...
December 1, 2016: Spine
https://www.readbyqxmd.com/read/27893477/an-evaluation-of-agonist-antagonist-strength-ratios-and-posture-among-powerlifters
#7
Paul T Cutrufello, Stephen J Gadomski, Nicholas A Ratamess
Powerlifters routinely focus on three exercises: bench press, squat, and deadlift. This focus may predispose them to the development of muscle imbalances in either the upper or lower extremity which might also influence posture. Therefore, the purpose of the present study was to examine the agonist:antagonist strength ratios and their relationship to postural measures among powerlifters. An expost facto study design compared fifteen male powerlifters (35.3±13.7 years old) and fifteen age-matched controls (34...
November 16, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27889355/cervical-sagittal-alignment-in-adult-hyperkyphosis-treated-by-posterior-instrumentation-and-in-situ-bending
#8
F Paternostre, Y P Charles, E A Sauleau, J-P Steib
BACKGROUND: In the normal adult spine, a link between thoracolumbar and cervical sagittal alignment exists, suggesting adaptive cervical positional changes allowing horizontal gaze. In patients with thoracic hyperkyphosis, cervical adaptation to sagittal global alignment might be different from healthy individuals. However, this relationship has not clearly been reported in hyperkyphotic deformity. PURPOSE: The purpose of this study was to identify cervical sagittal alignment types observed on radiographs in young adults with thoracic hyperkyphosis...
November 23, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27885474/comparison-of-mri-defined-back-muscles-volume-between-patients-with-ankylosing-spondylitis-and-control-patients-with-chronic-back-pain-age-and-spinopelvic-alignment-matched-study
#9
Doo Hee Bok, Jihye Kim, Tae-Hwan Kim
PURPOSE: To compare MRI-defined back muscle volume between AS patients and age, and spinopelvic alignment matched control patients with chronic back pain. METHODS: 51 male patients with AS were enrolled. Age and spinopelvic alignment matched controls (male) were found among non-AS patients with chronic back pain. After matching procedure, fully matched controls were found in 31 of 51 AS patients (60.8%), who represent AS patients without deformity. However, matched controls were not found in 20 of 51 AS patients (39...
November 24, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27885473/the-application-of-a-new-type-of-titanium-mesh-cage-in-hybrid-anterior-decompression-and-fusion-technique-for-the-treatment-of-continuously-three-level-cervical-spondylotic-myelopathy
#10
Xiaowei Liu, Yu Chen, Haisong Yang, Tiefeng Li, Haidong Xu, Bin Xu, Deyu Chen
PURPOSE: To evaluate the efficacy and safety of a new type of titanium mesh cage (NTMC) in hybrid anterior decompression and fusion method (HDF) in treating continuously three-level cervical spondylotic myelopathy (TCSM). METHODS: Ninety-four cases who had TCSM and accepted the HDF from Jan 2007 to Jan 2010 were included. Clinical and radiological outcomes were compared between cases who had the NTMC (Group A, n = 45) and traditional titanium mesh cage (TTMC, Group B, n = 49) after corpectomies...
November 24, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27885358/miniopen-transforaminal-lumbar-interbody-fusion-with-unilateral-fixation-a-comparison-between-ipsilateral-and-contralateral-reherniation
#11
Zheng Li, Fubing Liu, Shuhao Liu, Zixian Chen, Chun Jiang, Zhenzhou Feng, Xiaoxing Jiang
The aim of this study was to evaluate the risk factors between ipsilateral and contralateral reherniation and to compare the effectiveness of miniopen transforaminal lumbar interbody fusion (TLIF) with unilateral fixation for each group. From November 2007 to December 2014, clinical and radiographic data of each group (ipsilateral or contralateral reherniation) were collected and compared. Functional assessment (Visual Analog Scale (VAS) score and Japanese Orthopaedic Association (JOA)) and radiographic evaluation (fusion status, disc height, lumbar lordosis (LL), and functional spine unit (FSU) angle) were applied to compare surgical effect for each group preoperatively and at final followup...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27879576/analysis-of-sagittal-parameters-in-patients-undergoing-one-or-two-level-closing-wedge-osteotomy-for-correcting-thoracolumbar-kyphosis-secondary-to-ankylosing-spondylitis
#12
Wen-Bin Hua, Yu-Kun Zhang, Yong Gao, Xian-Zhe Liu, Shu-Hua Yang, Xing-Huo Wu, Jing Wang, Cao Yang
STUDY DESIGN: Retrospective analysis of clinical records. OBJECTIVE: To assess and compare the improvement in sagittal balance after one- or two-level closing wedge osteotomy for correcting thoracolumbar kyphosis secondary to ankylosing spondylitis (AS). SUMMARY OF BACKGROUND DATA: Closing wedge osteotomy represents a common approach to correct kyphosis in AS. While several reports have described the outcomes of one- or two-level closing wedge osteotomy in terms of sagittal parameters, data comparing the outcomes of these procedures are scarce...
November 22, 2016: Spine
https://www.readbyqxmd.com/read/27879571/radiographic-predictors-for-mechanical-failure-following-adult-spinal-deformity-surgery-a-retrospective-cohort-study-in-138-patients
#13
Dennis Winge Hallager, Sven Karstensen, Naeem Bukhari, Martin Gehrchen, Benny Dahl
STUDY DESIGN: Retrospective cohort study at a single institution. OBJECTIVE: We aimed at estimating the rate of revision procedures and identify radiographic predictors of mechanical failure following adult spinal deformity surgery. SUMMARY OF BACKGROUND DATA: Mechanical failure rates following adult spinal deformity surgery range 12% to 37% in literature. While the importance of spinal and spino-pelvic alignment is well documented for surgical outcome and ideal alignment has been proposed as sagittal vertical axis (SVA) < 5 cm, pelvic tilt < 20° and lumbar lordosis (LL) = pelvic incidence ± 9°, the role of radiographic sagittal spine parameters and alignment targets as predictors for mechanical failure remains uncertain...
November 22, 2016: Spine
https://www.readbyqxmd.com/read/27875416/comparison-of-structural-disease-burden-to-health-related-quality-of-life-scores-in-264-adult-spinal-deformity-patients-with-2-year-follow-up-novel-insights-into-drivers-of-disability
#14
Joshua Bakhsheshian, Justin K Scheer, Jeffrey L Gum, Lance Horner, Richard Hostin, Virginie Lafage, Shay Bess, Themistocles S Protopsaltis, Douglas C Burton, Malla Keefe, Robert A Hart, Gregory M Mundis, Christopher I Shaffrey, Frank Schwab, Justin S Smith, Christopher P Ames
STUDY DESIGN: This is a review of a prospective multicenter database. OBJECTIVE: To investigate the relationship between preoperative disability and sagittal deformity in patients with high Oswestry Disability Index (ODI) and no sagittal malalignment, or low ODI and high sagittal malalignment. SUMMARY OF BACKGROUND DATA: The relationship between ODI and sagittal malalignment varies between each adult spinal deformity (ASD) patient. METHODS: A prospective multicenter database of 365 patients with ASD undergoing surgical reconstruction was analyzed...
November 21, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27871819/c7-sagittal-vertical-axis-is-the-determinant-of-the-c5-7-angle-in-cervical-sagittal-alignment
#15
Yoshitaka Matsubayashi, Hirotaka Chikuda, Yasushi Oshima, Yuki Taniguchi, Yoh Fujimoto, Takachika Shimizu, Sakae Tanaka
BACKGROUND CONTEXT: Previous studies have indicated that the T1 slope correlates with cervical lordosis. In contrast, the specific impact of C7 sagittal vertical axis (C7SVA) on cervical lordosis remains unknown. PURPOSE: This study aimed to investigate the specific role of C7SVA in cervical lordosis. STUDY DESIGN/SETTING: This was a retrospective radiographic study. PATIENT SAMPLE: 48 consecutive patients who underwent lateral standing radiography of the entire spine were retrospectively reviewed OUTCOME MEASURES: Radiographic parameters included occipito (Oc) -C7, Oc-C2, C2-7, C2-4, and C5-7 angles; T1 slope; C7SVA; T1 pelvic angle; pelvic incidence; pelvic tilt; and sacral slope...
November 15, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27865518/impact-of-surgical-correction-of-a-u-shaped-sacral-fracture-on-sagittal-spino-pelvic-alignment-regarding-one-case
#16
N Mansouri, T Graillon, K Farah, S Pesenti, B Blondel, S Fuentes
U-shaped sacral fractures are uncommon and are mostly the consequence of a high-energy kinetic trauma. The sacrum is a crucial element for sagittal alignment in a standing position as it determines the value of the pelvic incidence, which is a fixed and unchanging parameter for a given individual. We report the case of a 21-year-old man who underwent corrective surgery for a type II U-shaped fracture of the sacrum (according to the Roy-Camille classification), associated with a S1-S2 dislocation and sacral kyphosis that modified the patient's pelvic incidence...
December 2016: Neuro-Chirurgie
https://www.readbyqxmd.com/read/27864683/cervical-sagittal-alignment-variations-in-adolescent-idiopathic-scoliosis-patients-treated-with-thoraco-lumbo-sacral-orthosis
#17
Marco Corradin, Federico Canavese, Alain Dimeglio, Jean Dubousset
PURPOSE: Thoraco-lumbo-sacral orthosis (TLSO) is an effective treatment in adolescent idiopathic scoliosis (AIS) patients, but cervical sagittal alignment (CSA) variations after bracing have never been evaluated. The purpose of this study was to assess changes in CSA before, during and after TLSO treatment, and to determine whether patients developed cervical pain. METHODS: This was a retrospective study in 38 AIS patients (33 females; mean age 10.8 years) treated by TLSO...
November 18, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27861359/characterization-of-radiographic-features-of-consecutive-lumbar-spondylolisthesis
#18
Yapeng Sun, Hui Wang, Dalong Yang, Nan Zhang, Sidong Yang, Wei Zhang, Wenyuan Ding
Radiographic features of consecutive lumbar spondylolisthesis were retrospectively analyzed in a total of 17 patients treated for this condition at the Third Hospital of Hebei Medical University from June 2005 to March 2012.To investigate the radiographic features, pelvic compensatory mechanisms, and possible underlying etiologies of consecutive lumbar spondylolisthesis.To the best of our knowledge, there is no previous report concerning the characteristics of consecutive lumbar spondylolisthesis.The Taillard index and the lumbar lordosis (LL), pelvic incidence (PI), sacrum slope (SS), and pelvic tilt (PT) were determined on lateral X-ray images, and the angular displacement was analyzed on flexion-extension X-ray images...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27858694/goniometric-evaluation-of-the-spinal-sagittal-curves-in-children-and-adolescents-a-reliability-study
#19
Aristide Gravina, Claudio Ferraro, Patrizia Poli, Michele Barazzuol, Alessandra Del Felice, Stefano Masiero
BACKGROUND: Gold standard for spine deformities assessment is X rays, but the procedure bears a risk of exposure. OBJECTIVE: To investigate intra-rater and inter-rater reliability of a pocket compass needle goniometer (IncliMed®, University of Padua) to non-invasively evaluate spine curves in children and adolescents. METHODS: Prospective reliability study in a paediatric population (mean age 12.5 years ± 2.5). Children with spine deformities (Scheuermann's or postural kyphosis, idiopathic scoliosis) and healthy controls were included...
November 11, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/27856380/t9-versus-t10-as-the-upper-instrumented-vertebra-for-correction-of-adult-deformity-rationale-and-recommendations
#20
Hwee Weng Dennis Hey, Kimberly-Anne Tan, Christabel Shao-En Neo, Eugene Tze-Chun Lau, Denise Ai-Wen Choong, Leok-Lim Lau, Gabriel Ka-Po Liu, Hee-Kit Wong
BACKGROUND CONTEXT: Adult spinal deformity correction sometimes involves long posterior pedicle screw constructs extending from the lumbosacral spine to the thoracic vertebra. As fusion obliterates motion and places supraphysiological stress on adjacent spinal segments, it is crucial to ascertain the ideal upper instrumented vertebra (UIV) to minimize risk of proximal junctional failure (PJF). The T10 vertebra is often chosen to allow bridging of the thoracolumbar junction into the immobile thoracic vertebrae on the basis that it is the lowest immobile thoracic vertebra strut by the rib cage...
November 14, 2016: Spine Journal: Official Journal of the North American Spine Society
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