keyword
https://read.qxmd.com/read/38530917/clonal-expansion-of-a-streptococcus-pneumoniae-serotype-3-capsule-variant-sequence-type-700-with-enhanced-vaccine-escape-potential-after-13-valent-pneumococcal-conjugate-vaccine-introduction
#21
JOURNAL ARTICLE
Akuzike Kalizang'oma, Todd D Swarthout, Thandie S Mwalukomo, Arox Kamng'ona, Comfort Brown, Jacquline Msefula, Hayley Demetriou, Jia Mun Chan, Lucy Roalfe, Uri Obolski, Jose Lourenço, David Goldblatt, Chrispin Chaguza, Neil French, Robert S Heyderman
BACKGROUND: Streptococcus pneumoniae serotype 3 remains a problem globally. Malawi introduced 13-valent pneumococcal conjugate vaccine (PCV13) in 2011, but there has been no direct protection against serotype 3 carriage. We explored whether vaccine escape by serotype 3 is due to clonal expansion of a lineage with a competitive advantage. METHODS: The distribution of serotype 3 Global Pneumococcal Sequence Clusters (GPSCs) and sequence types (STs) globally was assessed using sequences from the Global Pneumococcal Sequencing Project...
March 26, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38530540/the-functional-study-of-response-regulator-arlr-mutants-in-staphylococcus-aureus
#22
JOURNAL ARTICLE
Jinhong Zhou, Moath Refat, Yucheng Guo, Jiaxin Zhang, Min Jiao, Wenbo He, Xiaoyu He, Mai A Rabie, Zhenlin Ouyang, Fang Zheng
Staphylococcus aureus is a major cause of hospital-associated infections worldwide. The organism's ability to form biofilms has led to resistance against current treatment options such as beta-lactams, glycopeptides, and daptomycin. The ArlRS two-component system is a crucial regulatory system necessary for S. aureus autolysis, biofilm formation, capsule synthesis, and virulence. This study aims to investigate the role of the arlR deletion mutant in the detection and activation of S. aureus. We created an arlR deleted mutant and complementary strains and characterized their impact on the strains using partial growth measurement...
March 26, 2024: Applied Biochemistry and Biotechnology
https://read.qxmd.com/read/38530462/interest-of-computer-tomography-in-the-study-of-prognostic-factors-of-otosclerosis
#23
JOURNAL ARTICLE
Rachida Bouatay, Chirine Benelhaj, Jamel Saad, Ahmed Zrig, Mehdi Ferjaoui, Amel Elkorbi, Naourez Kolsi, Khaled Harrathi, Jamel Koubaa
BACKGROUND: Otosclerosis is a primary osteodystrophy of the otic capsule that causes stapedo-vestibular ankylosis. Its diagnosis is suspected on the basis of clinical and audiometric elements, basically in the presence of conductive hearing loss with a normal eardrum. The CT-scan is an essential examination for the preoperative evaluation of otosclerosis. The aim of our study was to evaluate the use of CT-scanning in predicting the functional outcome of otosclerosis surgery by correlating postoperative audiometric results and preoperative CT findings...
March 26, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38530205/management-of-fixed-flexion-contracture-in-primary-total-knee-arthroplasty-recent-systematic-review
#24
JOURNAL ARTICLE
Elliot Sappey-Marinier, Andréa Fernandez, Jobe Shatrov, Cécile Batailler, Elvire Servien, Denis Huten, Sébastien Lustig
INTRODUCTION: This study aimed to systematically review the literature and identify the surgical management strategy for fixed flexion contracture in primary total knee arthroplasty (TKA) surgery, pre-, intra-, and post-operatively. Secondary endpoints were etiologies and factors favoring flexion contracture. MATERIALS AND METHODS: Searches were carried out in November 2023 in several databases (Pubmed, Scopus, Cochrane, and Google Scholar) using the following keywords: "flexion contracture AND TKA", "fixed flexion deformity AND TKA", "posterior capsular release AND TKA", "posterior capsulotomy in TKA", "distal femoral resection AND TKA"...
2024: SICOT-J
https://read.qxmd.com/read/38530085/tailored-yolk-shell-design-to-silicon-microparticles-via-scalable-and-template-free-synthesis-for-superior-lithium-storage
#25
JOURNAL ARTICLE
Hao Wu, Hong Wen, Chen Wang, Fenghui Li, Yifan Chen, Liwei Su, Lianbang Wang
Micrometer-sized Si particles are beneficial to practical lithium-ion batteries in regard to low cost and high volumetric energy density in comparison with nanostructured Si anodes. However, both the issues of electrical contact loss and overgrowth of solid electrolyte interface for microscale Si induced by colossal volume change still remain to be addressed. Herein, a scalable and template-free method is introduced to fabricate yolk-shell structured Si anode from commercially available Si microparticles. The void is created via a one-step alkali etching process with the remaining silicon core as the yolk, and a double-walled shell is formed from simultaneous in situ growth of the conformal native oxide layer and subsequent carbon coating...
March 26, 2024: Small
https://read.qxmd.com/read/38529957/pan-enteric-capsule-endoscopy-to-characterize-crohn-s-disease-phenotypes-and-predict-clinical-outcomes-in-children-and-adults-the-bomiro-study
#26
JOURNAL ARTICLE
Salvatore Oliva, Silvio Veraldi, Giusy Russo, Marina Aloi, Fernando Rizzello, Paolo Gionchetti, Patrizia Alvisi, Flavio Labriola, Maurizio Vecchi, Pini Eidler, Luca Elli, Nikolas Dussias, Gian Eugenio Tontini, Carlo Calabrese
BACKGROUND: Pan-enteric capsule endoscopy (PCE) provides useful information for the management of Crohn's disease (CD), especially in children. No study has evaluated the ability of PCE to characterize CD phenotypes and outcomes in children and adults. METHODS: In a prospective multicenter observational study, we recruited patients with CD >6 years from 4 centers in Italy. Patients underwent clinical, biomarker assessment and PCE. Lesions were graded using the PCE system...
March 26, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38529394/ultrasound-guided-fine-needle-aspiration-thyroglobulin-in-the-diagnosis-of-lymph-node-metastasis-of-differentiated-papillary-thyroid-carcinoma-and-its-influencing-factors
#27
JOURNAL ARTICLE
Xuejiao Su, Lei Shang, Can Yue, Buyun Ma
BACKGROUND: Ultrasound-guided fine needle aspiration thyroglobulin (FNA-Tg) is recommended for the diagnosis of lymph node metastasis (LNM) in differentiated thyroid cancer (DTC), but its optimal cutoff value remains controversial, and the effect of potential influencing factors on FNA-Tg levels is unclear. METHOD: In this study, a retrospective analysis was conducted on 281 patients diagnosed with DTC, encompassing 333 lymph nodes. We analyze the optimal cutoff value and diagnostic efficacy of FNA-Tg, while also evaluating the potential influence of various factors on FNA-Tg...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38529358/-helicobacter-pylori-persistent-infection-burden-and-structural-brain-imaging-markers
#28
JOURNAL ARTICLE
May A Beydoun, Hind A Beydoun, Yi-Han Hu, Ziad W El-Hajj, Michael F Georgescu, Nicole Noren Hooten, Zhiguang Li, Jordan Weiss, Donald M Lyall, Shari R Waldstein, Dawson W Hedges, Shawn D Gale, Lenore J Launer, Michele K Evans, Alan B Zonderman
Persistent infections, whether viral, bacterial or parasitic, including Helicobacter pylori infection, have been implicated in non-communicable diseases, including dementia and other neurodegenerative diseases. In this cross-sectional study, data on 635 cognitively normal participants from the UK Biobank study (2006-21, age range: 40-70 years) were used to examine whether H. pylori seropositivity (e.g. presence of antibodies), serointensities of five H. pylori antigens and a measure of total persistent infection burden were associated with selected brain volumetric structural MRI (total, white, grey matter, frontal grey matter (left/right), white matter hyperintensity as percent intracranial volume and bi-lateral sub-cortical volumes) and diffusion-weighted MRI measures (global and tract-specific bi-lateral fractional anisotropy and mean diffusivity), after an average 9-10 years of lag time...
2024: Brain communications
https://read.qxmd.com/read/38529352/fabrication-of-a-3d-bioprinting-model-for-posterior-capsule-opacification-using-gelma-and-plma-hydrogel-coated-resin
#29
JOURNAL ARTICLE
Xin Liu, Jiale Li, Shuyu Liu, Yan Long, Ching Kang, Chen Zhao, Ling Wei, Shaoqi Huang, Yi Luo, Bo Dai, Xiangjia Zhu
Posterior capsule opacification (PCO) remains the predominant complication following cataract surgery, significantly impairing visual function restoration. In this study, we developed a PCO model that closely mimics the anatomical structure of the crystalline lens capsule post-surgery. The model incorporated a threaded structure for accurate positioning and observation, allowing for opening and closing. Utilizing 3D printing technology, a stable external support system was created using resin material consisting of a rigid, hollow base and cover...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38528685/the-effect-of-ibuprofen-sustained-release-oral-premedication-on-intraoperative-and-postoperative-pain-a-randomised-clinical-trial
#30
JOURNAL ARTICLE
Mariam Ahmed Hossam, Alaa Abdelsalam El Baz, Sang Won Kwak, Hyeon-Cheol Kim, Mohamed Mohsen Abielhassan
The aim of this study was to assess the effect of ibuprofen sustained release (SR) oral premedication on the efficacy of buccal infiltration (BI) with intraoperative and postoperative pain after single-visit root canal treatment. Sixty patients diagnosed with symptomatic irreversible pulpitis and apical periodontitis in mandibular molar were divided into two groups. Group SR received ibuprofen SR 800 mg and group PL received placebo capsule 1 h before 3.6 mL articaine BI injection. Pain was recorded using a modified visual analogue scale and postoperatively at intervals 6, 24 and 48 h...
March 25, 2024: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://read.qxmd.com/read/38527297/development-and-validation-of-a-deep-learning-system-for-detection-of-small-bowel-pathologies-in-capsule-endoscopy-a-pilot-study-in-a-singapore-institution
#31
JOURNAL ARTICLE
Bochao Jiang, Michael Dorosan, Justin Wen Hao Leong, Marcus Eng Hock Ong, Sean Shao Wei Lam, Tiing Leong Ang
INTRODUCTION: Deep learning models can assess the quality of images and discriminate among abnormalities in small bowel capsule endoscopy (CE), reducing fatigue and the time needed for diagnosis. They serve as a decision support system, partially automating the diagnosis process by providing probability predictions for abnormalities. METHODS: We demonstrated the use of deep learning models in CE image analysis, specifically by piloting a bowel preparation model (BPM) and an abnormality detection model (ADM) to determine frame-level view quality and the presence of abnormal findings, respectively...
March 1, 2024: Singapore Medical Journal
https://read.qxmd.com/read/38526292/henneguya-cnidaria-myxobolidae-species-infecting-oligosarcus-jenynsii-characiformes-characidae-in-a-neotropical-shallow-lake-from-argentina-morphological-and-molecular-characterisation
#32
JOURNAL ARTICLE
Maria Alejandra Rossin, Delfina Maria Paula Cantatore, Martina Lisnerova, Veronica Taglioretti, Astrid Sibylle Holzer
Two previously undescribed myxozoan species, Henneguya sardellae sp. n. and H. margaritae sp. n., found infecting connective tissues of the Neotropical characid fish Oligosarcus jenynsii (Günther) from Argentina are morphologically and molecularly characterised. Mature spores of H. sardellae sp. n. are ellipsoid, with two, straight and visibly fused caudal appendages cleaved at its blunt terminal end; measuring 33.5 ± 1.2 (30.9-35.5) μm in total length, spore body 17.5 ± 0.6 (16.3-18.6) µm, 7...
February 20, 2024: Folia Parasitologica
https://read.qxmd.com/read/38526220/supramolecular-handshakes-characterization-of-urea-carboxylate-interactions-within-calixarene-frameworks
#33
JOURNAL ARTICLE
Marija Cvetnić, Nikola Cindro, Edi Topić, Nikola Bregovic, Vladislav Tomišić
The research of molecular capsules offers high application potential and numerous benefits in various fields. With the aim of forming supramolecular capsules which can be reversibly assembled and dissociated by simple external stimuli, we studied interactions between calixarenes containing urea and carboxylate moieties. To this end two ureido-derivatives of p-tert-butylcalix[4]arene comprising phenylureido-moieties and diacetate-calix[4]arenes were prepared. The binding of acetate by ureido-derivatives of calixarene in acetonitrile was characterized, revealing high affinity of ureido-calixarenes for carboxylates...
March 25, 2024: ChemPlusChem
https://read.qxmd.com/read/38524871/coenzyme-q10-a-key-antioxidant-in-the-management-of-diabetes-induced-cardiovascular-complications-an-overview-of-mechanisms-and-clinical-evidence
#34
REVIEW
Fatemeh Samimi, Nasim Namiranian, Ali Sharifi-Rigi, Morvarid Siri, Omid Abazari, Sanaz Dastghaib
BACKGROUND: Diabetes mellitus (DM) presents a significant global health challenge with considerable cardiovascular implications. Coenzyme Q10 (CoQ10) has gained recognition for its potential as a natural antioxidant supplement in the management of diabetes and its associated cardiovascular complications. AIM: This comprehensive review systematically examines the scientific rationale underlying the therapeutic properties of CoQ10 in mitigating the impact of diabetes and its cardiovascular consequences...
2024: International Journal of Endocrinology
https://read.qxmd.com/read/38524751/safety-and-efficacy-of-a-polyherbal-formulation-from-traditional-persian-medicine-in-patients-with-calcium-kidney-stones-a-randomized-double-blinded-clinical-trial
#35
JOURNAL ARTICLE
Ramin Ansari, Iman Karimzade, Majid Nimrouzi, Shahrokh Ezatzadegan, Mohammad Mehdi Hosseini, Mohammad Mehdi Zarshenas
BACKGROUND: 10%-15% of the world's population suffers from kidney stones. Nearly 50% increase was observed in diagnosing and treating nephrolithiasis in the last decades. Effective medical treatment for the disease is not yet well established. Moreover, there is an increasing global demand to manage diseases using complementary and alternative medicine. This study aimed to formulate and assess the safety and efficacy of a multi-ingredient formulation from traditional Persian medicine (TPM) known as Mofatet powder in patients suffering from calcium kidney stones...
2024: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://read.qxmd.com/read/38524654/giant-retroperitoneal-myolipoma-mimicking-liposarcoma-report-of-a-resected-case-and-review-of-the-literature
#36
JOURNAL ARTICLE
Kosuke Mori, Takamichi Igarashi, Akira Noguchi, Miki Ito, Yasuhiro Nagaoka, Chitaru Takeshita, Naoya Takeda, Toru Watanabe, Isaku Yoshioka, Kenichi Hirabayashi, Tsutomu Fujii
Myolipomas are rare tumors that are often difficult to differentiate from liposarcoma. Herein, we report a case of resected giant myolipoma preoperatively diagnosed as liposarcoma. A 63-year-old woman was suspected of having a large retroperitoneal liposarcoma on October 202X. The patient was referred to our department for tumor resection and a histological diagnosis. After consultation with the urology, obstetric and gynecology, and vascular surgery departments, tumor resection was planned, including the potential resection of other organs...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38524501/study-of-peg-b-pla-eudragit-s100-blends-on-the-nanoencapsulation-of-indigo-carmine-dye-and-application-in-controlled-release
#37
JOURNAL ARTICLE
Shaked Ashkenazi, Pnina Matsanov, Eid Nassar-Marjiya, Shady Farah, Iris S Weitz
A nanocapsule shell of poly(ethylene glycol)- block -poly(d,l-lactic acid) (PEG- b -PLA) mixed with anionic Eudragit S100 (90/10% w/w) was previously used to entrap and define the self-assembly of indigo carmine (IC) within the hydrophilic cavity core. In the present work, binary blends were prepared by solution mixing at different PEG- b -PLA/Eudragit S100 ratios (namely, 100/0, 90/10, 75/25, and 50/50% w/w) to elucidate the role of the capsule shell in tuning the encapsulation of the anionic dye (i.e., IC)...
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38524415/simple-and-practical-method-for-the-quantitative-high-sensitivity-analysis-of-n-nitroso-duloxetine-in-duloxetine-drug-products-utilizing-lc-ms-ms
#38
JOURNAL ARTICLE
Shohei Fukuda, Yumiko Nakase, Kazuhide Imagaki, Kanako Kondo, Takahiko Taniguchi, Osamu Uchikawa
The high-sensitivity analytical method for the determination of N -nitroso duloxetine (NDXT), which can be carcinogenic and harmful in duloxetine drug products, was successfully developed utilizing liquid chromatography-tandem mass spectrometry (LC-MS/MS). Tandem mass spectrometric detection at positive electrospray ionization in multiple reaction monitoring (MRM) mode was then employed for the determination of NDXT. The quantitative range for NDXT was found in 0.075-3.75 ng/mL in terms of concentration in the dilution solvent for duloxetine active pharmaceutical ingredient (API) and capsules and 0...
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38524382/trigeminal-neuralgia-revealing-an-epidermoid-cyst-impinging-on-the-vth-cranial-nerve-a-case-report
#39
Messaoud Ola, Guelzim Yousra, Sqalli Houssaini Abdelkader, Fikri Meriem, Jiddane Mohamed, Touarsa Firdaous
Intracranial epidermoid cysts, also referred to as intracranial primary cholesteatomas, are uncommon, benign tumors characterized by slow, linear growth patterns akin to normal epidermal tissue. They typically become symptomatic around age 43, with a slight female predominance, and are most frequently located in the cerebellopontine angle. This summary presents the case of a 62-year-old woman suffering from paroxysmal excruciating pain of the right hemiface, indicative of trigeminal neuralgia, linked to an intracranial epidermoid cyst in the cerebellopontine angle...
2024: SAGE Open Medical Case Reports
https://read.qxmd.com/read/38524025/efficacy-and-safety-of-astaxanthin-in-the-management-of-oral-submucous-fibrosis-a-preliminary-randomized-controlled-trial
#40
JOURNAL ARTICLE
Elumalai Perumal, Santosh Patil, Mohmed Isaqali Karobari
BACKGROUND: Oral submucous fibrosis (OSMF) is a chronic, potentially malignant disorder characterized by progressive fibrosis of the oral mucosa, leading to restricted mouth opening and discomfort. This study investigates the efficacy and safety of astaxanthin, a potent antioxidant and anti-inflammatory carotenoid, in the comprehensive management of OSMF. METHODS: A randomized, double-blind, placebo-controlled trial was conducted with 68 eligible participants diagnosed with OSMF...
February 2024: Curēus
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