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https://www.readbyqxmd.com/read/28813079/diffusion-tensor-imaging-of-brain-white-matter-in-huntington-gene-mutation-individuals
#1
Roberta Arb Saba, James H Yared, Thomas M Doring, Med Phys, Vanderci Borges, Henrique Ballalai Ferraz
Objective: To evaluate the role of the involvement of white matter tracts in huntingtin gene mutation patients as a potential biomarker of the progression of the disease. Methods: We evaluated 34 participants (11 symptomatic huntingtin gene mutation, 12 presymptomatic huntingtin gene mutation, and 11 controls). We performed brain magnetic resonance imaging to assess white matter integrity using diffusion tensor imaging, with measurement of fractional anisotropy...
August 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28811698/effect-of-tulsi-ocimum-sanctum-linn-supplementation-on-metabolic-parameters-and-liver-enzymes-in-young-overweight-and-obese-subjects
#2
Swayamjeet Satapathy, Namrata Das, Debapriya Bandyopadhyay, Sushil Chandra Mahapatra, Dip Sundar Sahu, Mruthyumjayarao Meda
Ocimum sanctum Linn. (also known as Tulsi) is a sacred Indian plant, the beneficial role of which, in obesity and diabetes is described traditionally. This is a randomized, parallel group, open label pilot study to investigate the effect of O. sanctum on metabolic and biochemical parameters in thirty overweight/obese subjects, divided into two groups A and B. Group A (n = 16) received one 250 mg capsule of Tulsi (O. sanctum) extract twice daily in empty stomach for 8 weeks and group B (n = 14) received no intervention...
July 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28811108/methylene-blue-guided-debridement-as-an-intraoperative-adjunct-for-the-surgical-treatment-of-periprosthetic-joint-infection
#3
Jeremy D Shaw, Steve Miller, Anna Plourde, Daniel L Shaw, Rosanna Wustrack, Erik N Hansen
BACKGROUND: Current methods to identify infected tissue in periprosthetic joint infection (PJI) are inadequate. The purpose of this study was (1) to assess methylene blue-guided surgical debridement as a novel technique in PJI using quantitative microbiology and (2) to evaluate clinical success based on eradication of infection and infection-free survival. METHODS: Sixteen total knee arthroplasty patients meeting Musculoskeletal Infection Society criteria for PJI undergoing the first stage of 2-stage exchange arthroplasty were included in this prospective study...
July 21, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28810654/roles-of-p38-and-jnk-protein-kinase-pathways-activated-by-compound-cantharidin-capsules-containing-serum-on-proliferation-inhibition-and-apoptosis-of-human-gastric-cancer-cell-line
#4
Yonghao Sun, Dejuan Zhang, Mao Mao, Yangping Lu, Ning Jiao
The aim of the present study was to investigate the inhibitory effect of compound cantharides capsules (CCCs) on the viability and apoptosis of human gastric cancer cell lines, BGC-823 and SGC-7901, and to detect its regulation of gene expression levels, as well as its inhibition mechanisms. Each cell line was grouped into a control group, CCC serum group, 5-fluorouracil (5-FU) group, combination therapy group (CCC serum + 5-FU) and serum control group. Growth curves were measured and flow cytometry was used to detect cell apoptosis and cell viability...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810644/feasibility-of-a-novel-low-volume-and-sodium-phosphate-free-bowel-preparation-regimen-for-colon-capsule-endoscopy
#5
Jieqiong Zhou, Xiaowei Tang, Jing Wang, Zhenyu Chen, Xinying Wang, Bo Jiang
Bowel preparation regimens for colon capsule endoscopy are not yet standardized since they are not well optimized. The aim of the present study was to evaluate the feasibility of a novel low-volume and sodium phosphate-free bowel preparation regimen for colon capsule endoscopy. A total of 31 patients were prospectively enrolled. In the novel regimen, on the day prior to examination, a low-fiber diet was permitted, 5 mg mosapride citrate was administered twice (1 h prior to lunch and supper) and 1 l polyethylene glycol was administered in the evening...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810562/anti-depressant-like-effects-of-jieyu-chufan-capsules-in-a-mouse-model-of-unpredictable-chronic-mild-stress
#6
Hui Zhao, Bingyu Liang, Linjie Yu, Yun Xu
Jieyu chufan (JYCF) is a well-known Chinese traditional medicine used for depression; however, the molecular mechanism underlying its anti-depressant action has remained elusive. In the present study, the anti-depressant effects of JYCF and the potential mechanisms were investigated in a mouse model. Five groups of 12 C57BL/6 mice each were used in the study, including a normal control group (NC group), a model control group (MC group) and three groups, which received different doses of JYCF (1.25, 2.5 and 5 g/kg) orally for 21 days (JYCF groups)...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810527/icariin-combined-with-snailase-shows-improved-intestinal-hydrolysis-and-absorption-in-osteoporosis-rats
#7
Congyan Liu, Xia Gao, Yuping Liu, Mengmeng Huang, Ding Qu, Yan Chen
Icariin has a significant anti-osteoporotic activity, but its clinical application is limited due to a poor oral bioavailability especially under pathological conditions like osteoporosis. Based on the intestinal absorption and metabolism characteristics of icariin in the osteoporosis rats, a kind of simple enteric capsules containing icariin and snailase was designed to overcome this issue in this study. Snailase was secleted as the most efficient exogenous hydrolase of icariin and the related hydrolysis reaction parameters were optimized in the artificial intestinal liquid...
August 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28809796/polymeric-and-lipid-membranes-from-spheres-to-flat-membranes-and-vice-versa
#8
REVIEW
Mariia S Saveleva, Ekaterina V Lengert, Dmitry A Gorin, Bogdan V Parakhonskiy, Andre G Skirtach
Membranes are important components in a number of systems, where separation and control of the flow of molecules is desirable. Controllable membranes represent an even more coveted and desirable entity and their development is considered to be the next step of development. Typically, membranes are considered on flat surfaces, but spherical capsules possess a perfect "infinite" or fully suspended membranes. Similarities and transitions between spherical and flat membranes are discussed, while applications of membranes are also emphasized...
August 15, 2017: Membranes
https://www.readbyqxmd.com/read/28808905/a-pharmacokinetic-bioequivalence-study-comparing-pirfenidone-tablet-and-capsule-dosage-forms-in-healthy-adult-volunteers
#9
Lin Pan, Paula Belloni, Han Ting Ding, Jianshuang Wang, Christopher M Rubino, Wendy S Putnam
INTRODUCTION: Pirfenidone film-coated tablets were developed to offer an alternative to the marketed capsule formulation. This study assessed the bioequivalence of the tablet and capsule formulations under fed and fasted states. METHODS: A Phase I, open-label, randomized, four-treatment-period, four-sequence, crossover pharmacokinetics study (NCT02525484) was conducted. Each subject received an 801-mg single dose of pirfenidone as three 267-mg capsules or one 801-mg tablet under fasted and fed conditions...
August 14, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28808624/possibilities-for-arthroscopic-treatment-of-the-ageing-sternoclavicular-joint
#10
Martin Rathcke, Jørgen Tranum-Jensen, Michael Rindom Krogsgaard
AIM: To investigate if there are typical degenerative changes in the ageing sternoclavicular joint (SCJ), potentially accessible for arthroscopic intervention. METHODS: Both SCJs were obtained from 39 human cadavers (mean age: 79 years, range: 59-96, 13 F/26 M). Each frozen specimen was divided frontally with a band saw, so that both SCJs were opened in the same section through the center of the discs. After thawing of the specimens, the condition of the discs was evaluated by probing and visual inspection...
July 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28808155/roca-is-an-accessory-protein-to-the-virulence-regulating-covr-s-two-component-system-in-the-group-a-streptococcus
#11
Ira Jain, Eric W Miller, Jessica L Danger, Kathryn J Pflughoeft, Paul Sumby
Regulating gene expression during infection is critical to the ability of pathogens to circumvent the immune response and cause disease. This is true for the group A Streptococcus (GAS), a pathogen that causes both invasive (e.g. necrotizing fasciitis) and non-invasive (e.g. pharyngitis) diseases. The control of virulence (CovR/S) two-component system has a major role in regulating GAS virulence factor expression. The regulator of cov (RocA) protein, which is a predicted kinase, functions in an undetermined manner through CovR/S to alter gene expression and reduce invasive disease virulence...
August 14, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28807347/dorsoradial-instability-of-the-thumb-metacarpophalangeal-joint-a-biomechanical-investigation
#12
Byung-Sung Kim, Alex Doermann, Michelle McGarry, Masaki Akeda, Hansel Ihn, Thay Q Lee
PURPOSE: To define the role of the dorsal capsule and associated dorsal fibrocartilage (DFC) and their interactions with the radial collateral ligament (RCL) as a thumb metacarpophalangeal (MCP) joint stabilizer. METHODS: Eight cadaveric thumbs were mounted onto a custom jig with 20 N of muscle load applied. The thumb position in space was digitized to measure ulnar-radial, pronation-supination, and volar-dorsal laxity at 0°, 30°, and 60° MCP joint flexion. Serial sectioning was performed and measurements were repeated for the intact state, proper RCL insufficiency, proper and accessory (complete) RCL insufficiency, complete RCL with 50% DFC (radial) insufficiency, and complete RCL with complete DFC insufficiency...
August 11, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28806859/analysis-of-low-molecular-weight-compounds-using-maldi-and-ldi-tof-ms-direct-detection-of-active-pharmaceutical-ingredients-in-different-formulations
#13
João L Bronzel, Cintia D F Milagre, Humberto M S Milagre
Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) is a high throughput, easy to use analytical technique. The simple sample preparation of this technique and its tolerance to the presence of contaminants are among its advantages. In contrast, depending on the matrix used, MALDI can ionize and generates ions in the low m/z range that complicate the interpretation of the spectra of low molecular weight compounds. To address this issue, one can envisage the use of tunable ionic matrices that can reduce the low m/z interferents...
August 14, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28806498/pacinian-corpuscles-in-human-lymph-nodes
#14
J Feito, J L Cobo, A Santos-Briz, J A Vega
The occurrence of Pacinian corpuscles associated to lymph nodes is an anatomical rarity and very scarce information exists in this regard. Here we examined immunohistochemically four Pacinian corpuscles found in the close vicinity of the hiliar blood vessels of lymph nodes (2 cervical, 1 axillary, and 1 inguinal) during routine surgical pathology. Pacinian corpuscles were normally arranged and displayed a pattern of protein distribution as follows: the axon was positive for neurofilament proteins and neuron specific enolase, the inner core cells showed intense S100 protein and vimentin immunostaining while they were negative for glial fibrillary acidic protein, type IV collagen and glucose transporter 1; vimentin, type IV collagen, and glucose transporter 1 were also observed also in the outer-core and the capsule...
August 14, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28806322/reduced-field-of-view-diffusion-weighted-magnetic-resonance-imaging-of-the-prostate-at-3-tesla-comparison-with-standard-echo-planar-imaging-technique-for-image-quality-and-tumor-assessment
#15
Tsutomu Tamada, Justin M Ream, Ankur M Doshi, Samir S Taneja, Andrew B Rosenkrantz
OBJECTIVE: The purpose of this study was to compare image quality and tumor assessment at prostate magnetic resonance imaging (MRI) between reduced field-of-view diffusion-weighted imaging (rFOV-DWI) and standard DWI (st-DWI). METHODS: A total of 49 patients undergoing prostate MRI and MRI/ultrasound fusion-targeted biopsy were included. Examinations included st-DWI (field of view [FOV], 200 × 200 mm) and rFOV-DWI (FOV, 140 × 64 mm) using a 2-dimensional (2D) spatially-selective radiofrequency pulse and parallel transmission...
August 12, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28806321/liver-imaging-reporting-and-data-system-discordance-between-computed-tomography-and-gadoxetate-enhanced-magnetic-resonance-imaging-for-detection-of-hepatocellular-carcinoma-major-features
#16
Victoria Chernyak, Milana Flusberg, Amy Law, Mariya Kobi, Viktoriya Paroder, Alla M Rozenblit
PURPOSE: The goal of this study was to compare agreement between computed tomography (CT) and magnetic resonance imaging (MRI) in the evaluation of the major Liver Imaging Reporting and Data System (LI-RADS) features used in assessment of hepatocellular carcinoma: arterial phase hyperenhancement (APHE), portal venous phase washout (WO), capsule appearance (capsule), and largest diameter (diameter). METHODS: Patients with liver protocol CT and gadoxetate-enhanced MRI within 1 month of each other and at least 1 discrete untreated liver lesion were included...
August 12, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28805022/hesperidin-supplementation-alleviates-oxidative-dna-damage-and-lipid-peroxidation-in-type-2-diabetes-a-randomized-double-blind-placebo-controlled-clinical-trial
#17
Fatemeh Homayouni, Fatemeh Haidari, Mehdi Hedayati, Mehrnoosh Zakerkish, Kambiz Ahmadi
This study aimed to examine the effects of hesperidin supplement on the glycemic parameters, oxidative DNA damage, and lipid peroxidation in patients with type 2 diabetes. Sixty-four patients were randomly allocated to receive 500 mg/day hesperidin or placebo capsules for 6 weeks. Data on glycemic parameters, total antioxidant capacity (TAC), 8-hydroxydeoxyguanosine (8-OHDG), and malondialdehyde (MDA) were collected at the baseline and at the end of the study. In hesperidin group, TAC increased (0.74 ± 0...
August 14, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28803418/clinical-results-after-microincision-biaxial-cataract-surgery-and-implantation-of-an-incise-intraocular-lens
#18
Wojciech Lubiński, Marta Kirkiewicz, Karolina Podborączyńska-Jodko
PURPOSE: To evaluate clinical outcomes after uncomplicated microincision biaxial cataract surgery and implantation of Incise intraocular lens (IOL). METHODS: This study included 47 eyes of 29 patients (mean age 62.2 ± 8.6 years), who underwent 1.4-mm biaxial cataract surgery with implantation of the Incise IOL (Bausch and Lomb). At third month, surgically induced astigmatism (SIA) was calculated. Three, 6 and 12 months postoperatively, uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), corrected near visual acuity (CNVA) LogMAR ETDRS, spherical equivalent refraction (SER), photopic distance corrected contrast sensitivity (CS) with and without glare (85 cd/m(2)) (CSV-1000) were assessed...
August 12, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28802227/anti-inflammatory-effects-of-shufengjiedu-capsule-for-upper-respiratory-infection-via-the-erk-pathway
#19
Yanmei Li, Nianwei Chang, Yanqi Han, Mengge Zhou, Jie Gao, Yuanyuan Hou, Min Jiang, Tiejun Zhang, Gang Bai
BACKGROUND: Shufengjiedu Capsule (SFJD) is a type of Chinese traditional medicine compound for the treatment of acute upper respiratory tract infection. The present work aims to decipher the mechanism of SFJD. METHODS: In this study, we used target prediction and RNA sequence (RNA-Seq) based on transcriptome analysis to clarify the inflammation-eliminating mechanism of SFJD. Firstly, Pseudomonas aeruginosa (PAK) was used to induce acute lung injury in KM mice. After being treated by SFJD, the differently expressed genes were analyzed by RNA-Seq...
August 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28801570/the-buckling-instability-of-aggregating-red-blood-cells
#20
Daniel Flormann, Othmane Aouane, Lars Kaestner, Christian Ruloff, Chaouqi Misbah, Thomas Podgorski, Christian Wagner
Plasma proteins such as fibrinogen induce the aggregation of red blood cells (RBC) into rouleaux, which are responsible for the pronounced shear thinning behavior of blood, control the erythrocyte sedimentation rate (ESR) - a common hematological test - and are involved in many situations of physiological relevance such as structuration of blood in the microcirculation or clot formation in pathological situations. Confocal microscopy is used to characterize the shape of RBCs within rouleaux at equilibrium as a function of macromolecular concentration, revealing the diversity of contact zone morphology...
August 11, 2017: Scientific Reports
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