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https://www.readbyqxmd.com/read/28340364/cervical-facet-force-analysis-after-disc-replacement-versus-fusion
#1
Vikas V Patel, Zachary R Wuthrich, Kirk C McGilvray, Matthew C Lafleur, Emily M Lindley, Derrick Sun, Christian M Puttlitz
BACKGROUND: Cervical total disc replacement was developed to preserve motion and reduce adjacent-level degeneration relative to fusion, yet concerns remain that total disc replacement will lead to altered facet joint loading and long-term facet joint arthrosis. This study is intended to evaluate changes in facet contact force, pressure and surface area at the treated and superior adjacent levels before and after discectomy, disc replacement, and fusion. METHODS: Ten fresh-frozen human cadaveric cervical spines were potted from C2 to C7 with pressure sensors placed into the facet joints of C3-C4 and C4-C5 via slits in the facet capsules...
March 18, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28339384/evaluation-of-the-most-frequently-prescribed-extemporaneously-compounded-veterinary-medications-at-a-large-independent-community-pharmacy
#2
Adel H Karara, Ryan Hines, Zehra Demir, Bethran Nnorom, Robert Horsey, Geoffrey Twigg
Extemporaneous drug formulation is essential to provide optimal pharmaceutical care to veterinary patients. The need for this is exacerbated by the fact that commercially produced veterinary-specific products, without a human indication, require specialty veterinary manufacturing facilities and a new animal drug application process to gain marketing approval. This study examined the prescription patterns of extemporaneously compounded veterinary preparations in the compounding department at a large independent community pharmacy...
November 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28335453/a-spatially-offset-raman-spectroscopy-method-for-non-destructive-detection-of-gelatin-encapsulated-powders
#3
Kuanglin Chao, Sagar Dhakal, Jianwei Qin, Yankun Peng, Walter F Schmidt, Moon S Kim, Diane E Chan
Non-destructive subsurface detection of encapsulated, coated, or seal-packaged foods and pharmaceuticals can help prevent distribution and consumption of counterfeit or hazardous products. This study used a Spatially Offset Raman Spectroscopy (SORS) method to detect and identify urea, ibuprofen, and acetaminophen powders contained within one or more (up to eight) layers of gelatin capsules to demonstrate subsurface chemical detection and identification. A 785-nm point-scan Raman spectroscopy system was used to acquire spatially offset Raman spectra for an offset range of 0 to 10 mm from the surfaces of 24 encapsulated samples, using a step size of 0...
March 18, 2017: Sensors
https://www.readbyqxmd.com/read/28335384/localization-and-tracking-of-implantable-biomedical-sensors
#4
REVIEW
Ilknur Umay, Barış Fidan, Billur Barshan
Implantable sensor systems are effective tools for biomedical diagnosis, visualization and treatment of various health conditions, attracting the interest of researchers, as well as healthcare practitioners. These systems efficiently and conveniently provide essential data of the body part being diagnosed, such as gastrointestinal (temperature, pH, pressure) parameter values, blood glucose and pressure levels and electrocardiogram data. Such data are first transmitted from the implantable sensor units to an external receiver node or network and then to a central monitoring and control (computer) unit for analysis, diagnosis and/or treatment...
March 13, 2017: Sensors
https://www.readbyqxmd.com/read/28334314/a-template-and-probabilistic-atlas-of-the-human-sensorimotor-tracts-using-diffusion-mri
#5
Derek B Archer, David E Vaillancourt, Stephen A Coombes
The purpose of this study was to develop a high-resolution sensorimotor area tract template (SMATT) which segments corticofugal tracts based on 6 cortical regions in primary motor cortex, dorsal premotor cortex, ventral premotor cortex, supplementary motor area (SMA), pre-supplementary motor area (preSMA), and primary somatosensory cortex using diffusion tensor imaging. Individual probabilistic tractography analyses were conducted in 100 subjects using the highest resolution data currently available. Tractography results were refined using a novel algorithm to objectively determine slice level thresholds that best minimized overlap between tracts while preserving tract volume...
March 14, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28334141/distribution-of-antimicrobial-resistance-determinants-virulence-associated-factors-and-crispr-loci-in-isolates-of-enterococcus-faecalis-from-various-settings-and-genetic-lineages
#6
Iwona Gawryszewska, Katarzyna Malinowska, Alicja Kuch, Dorota Chrobak-Chmiel, Lucja Laniewska-Trokenheim, Waleria Hryniewicz, Ewa Sadowy
Enterococcus faecalis represents an important factor of hospital-associated infections (HAIs). The knowledge on its evolution from a commensal to an opportunistic pathogen is still limited, thus we performed a study to characterize distribution of factors that may contribute to this adaptation. Using a collection obtained from various settings (hospitalized patients, community carriers, animals, fresh food, sewage, water) we investigated differences in antimicrobial susceptibility, distribution of antimicrobial resistance genes, virulence-associated determinants and phenotypes, and CRISPR loci in the context of the clonal relatedness of isolates...
March 1, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28333852/re-intervention-in-de-novo-vitreous-opacities-after-pars-plana-vitrectomy-in-familial-amyloidotic-polyneuropathy-ttr-val30metportuguese-patients
#7
Natália Novais Ferreira, David Afonso Cunha Dias, Rui Pedro Afonso Carvalho, Maria Teresa Pardal Monteiro Coelho
PURPOSE: To report management of de novo vitreous amyloid opacities after previous pars plana vitrectomy in familial amyloidotic polyneuropathy transthyretin Val30Met. METHODS: This work is a retrospective observational consecutive case series of five eyes of four patients. Demographic data, transthyretin mutation involved, age at the beginning of disease, duration of disease, treatment (liver transplant or tafamidis), time between vitrectomy and re-intervention, and ophthalmologic changes were evaluated...
March 22, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28333772/video-capsule-endoscopy-to-diagnose-primary-intestinal-lymphangiectasia-in-a-14-month-old-child
#8
S M van der Reijden, M P van Wijk, M A J M Jacobs, T G J de Meij
No abstract text is available yet for this article.
March 22, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28333662/basics-of-compounding-special-capsules
#9
Loyd V Allen
Capsules are among the most popular of all dosage forms. They are chemically and physically stable, easy to administer, attractive, and can be easily compounded. They can be easily tailored to meet the needs of individual patients regarding dosing, ingredients, etc. Also, more than one drug can be incorporated in each capsule to minimize the number of dosage forms the patient must take. Special capsules can be prepared outside the norm of containing only powders.
May 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28333188/autologous-collagen-matrix-acm-lower-pole-support-with-a-supero-anterior-capsular-flap-in-secondary-subpectoral-breast-augmentation
#10
Paolo Montemurro, Mubashir Cheema, Per Hedén, Stefano Avvedimento, Mouchammed Agko, Alessandro Quattrini Li
Background: Secondary aesthetic breast surgery is a complex and challenging scenario. It requires the surgeon to identify contributing factors, provide patient education, make a further management plan, and optimize the conditions for a favorable result. Various techniques have been described in literature but the rate of reoperation is still high. The first author has been using a supero-anterior capsular flap with a neopectoral subcapsular pocket and an implant change in these cases...
January 27, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28332831/layer-by-layer-assembly-of-amine-reactive-multilayers-using-an-azlactone-functionalized-polymer-and-small-molecule-diamine-linkers
#11
Yashira M Zayas-Gonzalez, Benjamin J Ortiz, David M Lynn
We report the reactive layer-by-layer assembly of amine-reactive polymer multilayers using an azlactone-functionalized polymer and small-molecule diamine linkers. This approach yields crosslinked polymer/linker-type films that can be further functionalized, after fabrication, by treatment with functional primary amines, and provides opportunities to incorporate other useful functionality that can be difficult to introduce using other polyamine building blocks. Films fabricated using poly(2-vinyl-4,4-dimethylazlactone) (PVDMA) and three model non-degradable aliphatic diamine linkers yielded reactive thin films that were stable upon incubation in physiologically relevant media...
March 23, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28332446/scaling-effects-in-spiral-capsule-robots
#12
Liang Liang, Rong Hu, Bai Chen, Yong Tang, Yan Xu
Spiral capsule robots can be applied to human gastrointestinal tracts and blood vessels. Because of significant variations in the sizes of the inner diameters of the intestines as well as blood vessels, this research has been unable to meet the requirements for medical applications. By applying the fluid dynamic equations, using the computational fluid dynamics method, to a robot axial length ranging from 10(-5) to 10(-2) m, the operational performance indicators (axial driving force, load torque, and maximum fluid pressure on the pipe wall) of the spiral capsule robot and the fluid turbulent intensity around the robot spiral surfaces was numerically calculated in a straight rigid pipe filled with fluid...
April 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28332339/sonographic-and-cytologic-differences-of-niftp-from-infiltrative-or-invasive-encapsulated-follicular-variant-of-papillary-thyroid-carcinoma-a-review-of-179-cases
#13
REVIEW
Grace C H Yang, Karen O Fried, Theresa Scognamiglio
We reclassified 179 cases of the follicular variant (FV) of papillary thyroid carcinoma (PTC) into 72 (40.2%) noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), 37 (20.7%) encapsulated FVPTC with invasion (EFVPTC), and 70 (39.1%) infiltrative FVPTC (IFVPTC) without a capsule. In the NIFTP group, 5.6% cytology were hypercellular and the remainder low to moderate cellularity. PTC nuclei were absent in 18%, focally present in 37.5%, and diffusely present in 44.4%. In the EFVPTC group, 8...
March 22, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28331784/photo-cross-linked-dual-responsive-hollow-capsules-mimicking-cell-membrane-for-controllable-cargo-post-encapsulation-and-release
#14
Xiaoling Liu, Dietmar Appelhans, Qiang Wei, Brigitte Voit
Multifunctional and responsive hollow capsules are ideal candidates to establish highly sophisticated compartments mimicking cell membranes for controllable bio-inspired functions. For this purpose pH and temperature dual-responsive and photo-cross-linked hollow capsules, based on silica-templated layer-by-layer approach by using poly(N-isopropyl acrylamide)-block-polymethacrylate) and polyallylamine, have been prepared to use them for the subsequent and easily available post-encapsulation process of protein-like macromolecules at room temperature and pH 7...
March 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28331364/silicone-induced-granuloma-of-breast-implant-capsule-sigbic-similarities-and-differences-with-anaplastic-large-cell-lymphoma-alcl-and-their-differential-diagnosis
#15
REVIEW
Eduardo de Faria Castro Fleury, Milena Morais Rêgo, Luciana Costa Ramalho, Veronica Jorge Ayres, Rodrigo Oliveira Seleti, Carlos Alberto Pecci Ferreira, Decio Roveda
Primary breast lymphoma is a rare disease and accounts for 0.5% of cases of breast cancer. Most primary breast lymphomas develop from B cells, and the involvement of T cells is rare. Anaplastic large cell lymphoma (ALCL) is a recently discovered T-cell lymphoma associated with breast implants. Only a few cases have been reported to date. It is believed that the incidence of ALCL is increasing because of the increasing number of breast implants. The clinical presentation is variable and can manifest as a palpable mass in the breast or armpit, breast pain, or capsular contracture...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28331003/phase-i-dose-escalation-study-of-taselisib-gdc-0032-an-oral-pi3k-inhibitor-in-patients-with-advanced-solid-tumors
#16
Dejan Juric, Ian Krop, Ramesh K Ramanathan, Timothy R Wilson, Joseph A Ware, Sandra Sanabria Bohorquez, Heidi Savage, Deepak Sampath, Laurent Salphati, Ray Lin, Huan Jin, Hema Parmar, Jerry Y Hsu, Daniel D Von Hoff, José Baselga
Taselisib is a potent and selective tumor growth inhibitor through PI3K pathway suppression. Thirty-four patients with locally advanced or metastatic solid tumors were treated (phase I study, modified 3+3 dose escalation; 5 cohorts; 3-16 mg taselisib once daily capsule). Taselisib pharmacokinetics were dose-proportional; mean half-life was 40 hours. Frequent dose-dependent, treatment-related adverse events included diarrhea, hyperglycemia, decreased appetite, nausea, rash, stomatitis, and vomiting. At 12 and 16 mg dose levels, dose limiting toxicities (DLT) were observed, with an accumulation of higher-grade adverse events after the cycle 1 DLT assessment window...
March 22, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28329521/a-rare-case-of-cutaneous-acanthamoebiasis-in-a-renal-transplant-patient
#17
Frank Winsett, Jessica Dietert, Jaime Tschen, Michael Swaby, Carolyn A Bangert
A 35-year-old woman receiving immunosuppressionfor renal transplantation presented with a onemonthhistory of tender skin nodules on herbilateral upper extremities. A skin biopsy revealedgranulomatous inflammation in the deep dermisand the subcutaneous fat with foci of necrosis.Within the foci of necrosis were large histiocytoidstructures with prominent nuclei. Periodic acid-Schiffstain revealed a round organism with a thick capsule,consistent with amoebal trophozoites. Testing withthe Center for Disease Control revealed the organismto be Acanthamoeba...
March 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329012/tracking-the-stochastic-fate-of-cells-of-the-renin-lineage-after-podocyte-depletion-using-multicolor-reporters-and-intravital-imaging
#18
Natalya V Kaverina, Hiroyuki Kadoya, Diana G Eng, Michael E Rusiniak, Maria Luisa S Sequeira-Lopez, R Ariel Gomez, Jeffrey W Pippin, Kenneth W Gross, Janos Peti-Peterdi, Stuart J Shankland
Podocyte depletion plays a major role in focal segmental glomerular sclerosis (FSGS). Because cells of the renin lineage (CoRL) serve as adult podocyte and parietal epithelial cell (PEC) progenitor candidates, we generated Ren1cCre/R26R-ConfettiTG/WT and Ren1dCre/R26R-ConfettiTG/WT mice to determine CoRL clonality during podocyte replacement. Four CoRL reporters (GFP, YFP, RFP, CFP) were restricted to cells in the juxtaglomerular compartment (JGC) at baseline. Following abrupt podocyte depletion in experimental FSGS, all four CoRL reporters were detected in a subset of glomeruli at day 28, where they co-expressed de novo four podocyte proteins (podocin, nephrin, WT-1 and p57) and two glomerular parietal epithelial cell (PEC) proteins (claudin-1, PAX8)...
2017: PloS One
https://www.readbyqxmd.com/read/28327882/new-morphological-data-and-molecular-diagnostic-of-henneguya-friderici-myxozoa-myxobolidae-a-parasite-of-leporinus-friderici-osteichthyes-anostomidae-from-southeastern-brazil
#19
Letícia Poblete Vidal, José Luis Luque
The myxozoan Henneguya friderici is a parasite of the gills, intestine, kidney and liver of Leporinus friderici, a characiform fish belonging to the family Anostomidae. Forty-two specimens of L. friderici that had been caught in the Mogi Guaçú River, state of São Paulo, were studied. Elongated white plasmodia were found in the gill filaments of 10 host specimens (24%). The mature spores had an ellipsoidal body with polar capsules of equal size and caudal length greater than body length. This study also described 18S rDNA sequencing of H...
March 16, 2017: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/28327802/in-vitro-and-in-vivo-antileishmanial-activity-of-artemisia-annua-l-leaf-powder-and-its-potential-usefulness-in-the-treatment-of-uncomplicated-cutaneous-leishmaniasis-in-humans
#20
Luz Estella Mesa, Daniel Vasquez, Pierre Lutgen, Iván Darío Vélez, Adriana María Restrepo, Isabel Ortiz, Sara María Robledo
INTRODUCTION: Cutaneous leishmaniasis (CL) is a tropical disease that affects millions of individuals worldwide. The current drugs for CL may be effective but have serious side effects; hence, alternatives are urgently needed. Although plant-derived materials are used for the treatment of various diseases in 80% of the global population, the validation of these products is essential. Gelatin capsules containing dried Artemisia annua leaf powder were recently developed as a new herbal formulation (totum) for the oral treatment of malaria and other parasitic diseases...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
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