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https://www.readbyqxmd.com/read/29884920/chemotherapy-induced-takotsubo-syndrome
#1
Monika Budnik, Jakub Kucharz, Paweł Wiechno, Tomasz Demkow, Janusz Kochanowski, Elżbieta Górska, Grzegorz Opolski
Cardiovascular complications are a significant problem in systemically treated cancer patients. One such complication is Takotsubo cardiomyopathy, also known as Takotsubo syndrome. It is most frequently defined as a sudden and transient left or right ventricular systolic dysfunction; mimicking acute coronary syndrome, but without the associated changes in coronary arteries. Takotsubo syndrome is a relatively little known complication that appears in the course of oncological treatment, and its incidence has not yet been established...
June 9, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29761372/outcomes-of-takotsubo-cardiomyopathy-in-hospitalized-cancer-patients
#2
Parijat Saurav Joy, Achuta Kumar Guddati, Iuliana Shapira
BACKGROUND: Chemotherapy-induced cardiomyopathy is a critical complication of treatment for cancer. The emotional stress of a cancer diagnosis, ongoing chemotherapy, abnormal cancer-related wasting syndrome may contribute to cardiac morbidity in these patients. The burden of Takotsubo Cardiomyopathy (TCM) in cancer patients is unknown. The incidence of TCM and related outcomes in cancer patients was investigated in this study. METHODS: The 2007-2013 National Inpatient Sample (NIS) was analyzed for patients with a prior and new diagnosis of TCM with and without malignancy...
May 14, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29670765/mending-a-broken-heart-treatment-of-stress-induced-heart-failure-after-solid-organ-transplantation
#3
REVIEW
N Thao Galván, Kayla Kumm, Michael Kueht, Cindy P Ha, Dor Yoeli, Ronald T Cotton, Abbas Rana, Christine A O'Mahony, Glenn Halff, John A Goss
Stress-induced heart failure, also known as Broken Heart Syndrome or Takotsubo Syndrome, is a phenomenon characterized as rare but well described in the literature, with increasing incidence. While more commonly associated with postmenopausal women with psychiatric disorders, this entity is found in the postoperative patient. The nonischemic cardiogenic shock manifests as biventricular failure with significant decreases in ejection fraction and cardiac function. In a review of over 3000 kidney and liver transplantations over the course of 17 years within two transplant centers, we describe a series of 7 patients with Takotsubo Syndrome after solid organ transplantation...
2018: Journal of Transplantation
https://www.readbyqxmd.com/read/29627435/ventricular-arrhythmias-and-sudden-cardiac-arrest-in-takotsubo-cardiomyopathy-incidence-predictive-factors-and-clinical-implications
#4
Laurence Jesel, Charlotte Berthon, Nathan Messas, Han S Lim, Mélanie Girardey, Halim Marzak, Benjamin Marchandot, Annie Trinh, Patrick Ohlmann, Olivier Morel
BACKGROUND: Takotsubo cardiomyopathy (TTC) is a stress-related transient cardiomyopathy. Life-threatening arrhythmias (LTA) can occur and worsen prognosis. OBJECTIVE: The purpose of this study was to assess the incidence and outcome of LTA in TTC, as well as its predictive factors and clinical implications. METHODS: We studied 214 consecutive cases of TTC over 8 years. The study cohort was divided into 2 groups: those with LTA (LTA group) and those without (non-LTA group)...
April 6, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29541614/role-of-echocardiography-for-takotsubo-cardiomyopathy-clinical-and-prognostic-implications
#5
REVIEW
Masaki Izumo, Yoshihiro J Akashi
Takotsubo cardiomyopathy (TTC) is newly-described secondary cardiomyopathy characterized by transient left ventricular (LV) dysfunction, which is increasingly recognized in the field of cardiology. TTC occurs in approximately 2% of the patients with acute coronary syndrome. Its onset is rare; however, its specific features play a crucial role in diagnosing the chest pain in clinical practice. TTC has generally favorable outcome with rapid recovery of LV function; however, an increasing evidence suggests that it should be regarded as a more serious acute cardiac disorder with a variety of complications...
February 2018: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/29518796/seasonal-variation-in-takotsubo-syndrome-compared-with-myocardial-infarction-anzacs-qi-16
#6
Jen-Li Looi, Mildred Lee, Corina Grey, Mark Webster, Andrew To, Andrew J Kerr
BACKGROUND: The incidence of myocardial infarction (MI) is characterised by seasonal variation, with a winter peak and summer trough. Takotsubo syndrome (TS) mimics MI, but is thought to have a distinct aetiology and may exhibit a reversed pattern of seasonal variation. This study investigated the seasonal variation in the incidence of TS in comparison to MI. METHODS: Two hundred and sixty consecutive patients with TS (95% women, median age 66 years) admitted between March 2004 and December 2016 in the Auckland region of New Zealand were identified...
March 9, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29404350/stress-induced-thrombus-prevalence-of-thromboembolic-events-and-the-role-of-anticoagulation-in-takotsubo-cardiomyopathy
#7
Mark R Heckle, Cody W McCoy, Oluwaseun A Akinseye, Rami N Khouzam
Background: Takotsubo cardiomyopathy (TCM), also known as stress-induced cardiomyopathy has a favorable prognosis with expected recovery in weeks. Left ventricular (LV) thrombus is a known complication of TCM, which can lead to embolization and potentially a stroke. The prevalence of LV thrombus and the role of anticoagulation have yet to be fully defined in this condition. Methods: We performed a search of published literature through PubMed and Scopus, which identified 282 patients with TCM in whom the incidence of LV thrombus and/or thromboembolic event was reported...
January 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29317766/clinical-characteristics-of-stress-cardiomyopathy-in-patients-with-acute-poisoning
#8
Ung Jeon, Samel Park, SangHo Park, Eun-Young Lee, Hyo-Wook Gil
Patients who attempt intentional suicide suffer from physical or emotional stress. This situation might be an important factor that causes takotsubo cardiomyopathy. We retrospectively investigated the clinical features of Takotsubo cardiomyopathy in patients with acute poisoning. This study included patients who were admitted from January 2010 to December 2015 because of intentional poisoning by ingestion. Among these patients, we selectively collected data of patients who underwent an echocardiogram. We divided the patients into three groups according to the echocardiogram; the non-cardiomyopathy group, the global hypokinesia group, and the takotsubo cardiomyopathy group...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29238364/age-related-differences-and-outcome-of-patients-with-takotsubo-syndrome
#9
Aydin Huseynov, Ibrahim El-Battrawy, Uzair Ansari, Katja Schramm, Xiaobo Zhou, Siegfried Lang, Martin Borggrefe, Ibrahim Akin
Background: Takotsubo syndrome (TS) is an important cardiac disease that affects predominantly postmenopausal women. This study was conducted to determine the impact of age on the short- and long-term outcome of TS patients. Methods & Results: The data from a collective of 114 TS patients with a mean follow-up of 1591 ± 1079 days was retrospectively analysed. The study population was divided into two groups (≤ 65 and > 65 years) so as to evaluate the impact of age on the short- and long-term mortality of TS patients...
October 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29203578/left-ventricular-thrombi-in-takotsubo-syndrome-incidence-predictors-and-management-results-from-the-geist-german-italian-stress-cardiomyopathy-registry
#10
Francesco Santoro, Thomas Stiermaier, Nicola Tarantino, Luisa De Gennaro, Christian Moeller, Francesca Guastafierro, Maria Francesca Marchetti, Roberta Montisci, Elena Carapelle, Tobias Graf, Pasquale Caldarola, Holger Thiele, Matteo Di Biase, Natale Daniele Brunetti, Ingo Eitel
BACKGROUND: Left ventricular (LV) thrombi during Takotsubo syndrome represent a potential complication and can be associated with cerebrovascular embolic events. The aim of this study was to evaluate the exact incidence, predictors, and management strategies of LV thrombi in patients with Takotsubo syndrome. METHODS AND RESULTS: We enrolled 541 consecutive patients in a multicenter international registry. Clinical features and echocardiographic data at admission, during hospitalization, and after 3 months were evaluated...
December 4, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29116173/incidence-and-prognostic-relevance-of-cardiopulmonary-failure-in-takotsubo-cardiomyopathy
#11
Ibrahim El-Battrawy, Siegfried Lang, Uzair Ansari, Katherine Sattler, Michael Behnes, Katja Schramm, Christian Fastner, Erol Tülümen, Xiaobo Zhou, Ursula Hoffmann, Martin Borggrefe, Ibrahim Akin
Recent studies have indicated that patients with takotsubo cardiomyopathy (TTC) have a higher mortality rate than the general population. There is a distinct possibility that TTC could be associated with adverse life-threatening complications like cardiopulmonary failure. Our institutional database constituted a collective of 114 patients diagnosed with TTC. The frequency, determinants and predictors of cardiopulmonary failure were assessed. The patients were subsequently classified into two groups based on the presence (n = 44, 38...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29096885/stress-induced-cardiomyopathy-in-cancer-patients
#12
Dana Elena Giza, Juan Lopez-Mattei, Pimprapa Vejpongsa, Ezequiel Munoz, Gloria Iliescu, Danai Kitkungvan, Saamir A Hassan, Peter Kim, Michael S Ewer, Cezar Iliescu
Takotsubo syndrome, also known as stress-induced cardiomyopathy (SC), is underrecognized in cancer patients. This study aims to investigate the incidence, natural history, and triggers of SC in cancer patients and its impact on cancer therapy and overall survival. A total of 30 subjects fulfilled the diagnostic criteria for SC at MD Anderson Cancer Center over a 6-year period. Clinical presentation, electrocardiogram, laboratory data, and transthoracic echocardiogram results registered during the acute phase and follow-up were collected...
December 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29039623/the-challenge-of-takotsubo-syndrome-heterogeneity-of-clinical-features
#13
Susanne Anna Schlossbauer, Jelena-Rima Ghadri, Frank Scherff, Christian Templin
Takotsubo syndrome (TTS) was first described in 1991 as a rare, spontaneous and completely reversible left ventricular regional systolic dysfunction. Today the incidence of TTS is estimated at 2% in patients with an initial diagnosis of acute coronary syndrome (ACS). Notably, the incidence can be as high as 5.9 to 7.5% in female patients. TTS occurs predominantly in postmenopausal women, but both sexes may be affected, at any age. Acute chest pain or dyspnoea is a characteristic symptom of TTS, but initial presentation can also include more severe disease manifestation such as acute heart failure with pulmonary oedema or haemodynamic instability, especially in an in-hospital setting...
October 17, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28989934/takotsubo-cardiomyopathy-with-a-rapidly-resolved-left-ventricular-thrombus
#14
Abdel Anabtawi, Paola C Roldan, Carlos A Roldan
This article presents the case of a 53-year-old man who presented with acute right superficial femoral and popliteal arterial thrombosis for which he underwent an emergent uncomplicated thrombectomy. He denied preceding cardiovascular or neurologic symptomatology and had no history of coronary or peripheral arterial disease, trauma, hypercoagulability, or malignancy. However, he reported having several days of intense emotional stress prior to presentation. His cardiac exam was normal, his electrocardiogram showed normal sinus rhythm and nonspecific ST-T wave abnormalities, and his troponin levels were normal...
July 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28833618/intra-operative-predictors-of-postoperative-takotsubo-syndrome-in-liver-transplant-recipients-an-exploratory-case-control-study
#15
Stephen Aniskevich, Ryan M Chadha, Prith Peiris, Cemal Burcin Taner, Klaus L Torp, Colleen S Thomas, Maria L Yataco, Sher-Lu Pai
INTRODUCTION: Takotsubo syndrome (TTS), also known as Takotsubo cardiomyopathy or stress-induced cardiomyopathy, has been described following a variety of surgeries and disease states. The relationship between intra-operative anesthesia management and the development of this syndrome has never been fully elucidated. OBJECTIVES: The primary objective of this study was to determine the relationship of multiple intra-operative factors on the pathogenesis of TTS. METHODS: A single-center retrospective review of all liver transplants performed at Mayo Clinic Florida from January 2005 to December 2014...
November 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28802178/cardiac-arrest-due-to-ventricular-fibrillation-in-a-23-year-old-woman-with-broken-heart-syndrome
#16
Marco Giuseppe Del Buono, Michael P O'Quinn, Paulo Garcia, Enrique Gerszten, Charlotte Roberts, F Gerald Moeller, Antonio Abbate
Broken heart syndrome, also known as takotsubo cardiomyopathy, is a syndrome characterized by a transient regional systolic dysfunction of the left ventricle associated to a psychological stress. We herein describe a case of a 23-year-old female habitual marijuana user who was resuscitated after cardiac arrest and then diagnosed with midventricular stress cardiomyopathy complicated by subendocardial hemorrhage. We discuss this unique pathological finding, the incidence of arrhythmias in this syndrome, and the possible relation with chronic cannabis and tobacco use...
September 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28743481/prevalence-and-prognostic-relevance-of-atrial-fibrillation-in-patients-with-takotsubo-syndrome
#17
MULTICENTER STUDY
Thomas Stiermaier, Francesco Santoro, Charlotte Eitel, Tobias Graf, Christian Möller, Nicola Tarantino, Francesca Guastafierro, Matteo Di Biase, Holger Thiele, Natale D Brunetti, Ingo Eitel
BACKGROUND: Takotsubo syndrome (TTS) is associated with a considerable risk of complications during the acute phase and substantial long-term mortality rates. Concomitant atrial fibrillation may have an impact on outcome in these patients. Aim of this study was to assess the prevalence and prognostic relevance of atrial fibrillation in TTS. METHODS: We performed an international, multicenter study including 387 TTS patients consecutively enrolled at 3 centers. Atrial fibrillation was defined as known history before admission or documented episodes during hospital stay...
October 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28726653/retrospective-study-of-evaluation-of-patients-with-st-elevation-myocardial-infarction-and-intact-coronary-arteries-evaluation-of-treatment-approaches-outcome-and-prognosis
#18
E Tsetskhladze, I Khintibidze
Myocardial infarction with normal coronary arteries is a well known pathology. It may or may not be associated with left ventricle wall motion abnormalities. Data was reviewed retrospectively for patients with ST elevation myocardial infarction who underwent cardiac catheterization. From the total number of patients evaluated 10.3% (17) patients had Myocardial Infarction with normal coronary arteries. Females were more likely to present with MINCA then males. Coronary flow was normal in 11 from 17 patients with MINCA...
June 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28718877/takotsubo-syndrome-in-hemodynamically-unstable-patients-admitted-to-the-intensive-care-unit-a-retrospective-study
#19
J Oras, J Lundgren, B Redfors, D Brandin, E Omerovic, H Seeman-Lodding, S-E Ricksten
INTRODUCTION: Takotsubo syndrome (TS) is an acute cardiac condition that is often triggered by critical illness but that has rarely been studied in the intensive care unit (ICU) setting. The aim of this study was to (i) estimate the incidence of TS in a hemodynamically unstable ICU-population; (ii) identify predictors of TS in this population; (iii) study the impact of TS on prognosis and course of hospitalization. METHODS: Medical records from all patients admitted to our general ICU from 2012 to 2015 were analyzed...
September 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28664012/cerebral-infarction-arising-from-takotsubo-cardiomyopathy-case-report-and-literature-review
#20
Yoshihiro Otani, Koji Tokunaga, Satoshi Kawauchi, Satoshi Inoue, Kyoichi Watanabe, Hideki Kiriyama, Kosuke Sakane, Kiyoaki Maekawa, Isao Date, Kengo Matsumoto
Although most patients with takotsubo cardiomyopathy have a favorable outcome, complications are not uncommon. Recent studies have reported an increase in incidence of cardioembolic complications; however, the association between takotsubo cardiomyopathy and stroke, in particular thromboembolic cerebral infarction, remains unclear. We reported a 44-year-old woman who had a cerebral infarction resulting from takotsubo cardiomyopathy. She had felt chest discomfort a few days prior to infarction, and later developed left hemiparesis...
October 2016: NMC Case Report Journal
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