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venereal diseases

Li-Rong Lin, Dan-Hong Lin, Man-Li Tong, Li-Li Liu, Jin-Yi Fan, Xiao-Zhen Zhu, Kun Gao, Mei-Jun Chen, Wei-Hong Zheng, Hui-Lin Zhang, Shu-Lian Li, Hui-Ling Lin, Zhi-Feng Lin, Jian-Jun Niu, Tian-Ci Yang
BACKGROUND: Neurosyphilis (NS) is difficult to diagnose, especially in syphilis patients with negative cerebrospinal fluid (CSF) rapid plasma reagin (RPR) or Venereal Disease Research Laboratory (VDRL) tests. METHODS: We conducted a cross-sectional study and an analysis of macrophage migration inhibitory factor (MIF) in syphilitic patients to identify a novel marker for the diagnosis of NS, with a focus on probable NS (NS with negative VDRL/RPR tests). For this purpose, CSF and serum MIF concentrations were determined in 43 NS and 43 syphilis/non-NS (N-NS) patients at the Zhongshan Hospital of the Medical College of Xiamen University from July 2014 to June 2015...
October 15, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
Kayla Dmytruk, Zachary Klaassen, Shenelle N Wilson, Reena Kabaria, Michael W Kemper, Martha K Terris, Ronald W Lewis, Durwood E Neal, Arthur M Smith
No abstract text is available yet for this article.
September 21, 2016: Urology
Cuini Wang, Kaiqi Wu, Qian Yu, Sufang Zhang, Zixiao Gao, Yudan Liu, Liyan Ni, Yuanyuan Cheng, Zhifang Guan, Mei Shi, Haikong Lu, Yongliang Lou, Pingyu Zhou
At present, diagnosis for neurosyphilis remains a major clinical challenge. Venereal Disease Research Laboratory (VDRL) titer of the cerebrospinal fluid (CSF) is suboptimally sensitive to diagnose neurosyphilis, which can be negative in neurosyphilis patients, especially in asymptomatic neurosyphilis patients. In the search for biomarkers of neurosyphilis, we investigated the chemokine profile in CSF of neurosyphilis patients and found that the concentrations of CXCL13, CXCL10 and CXCL8 were selectively elevated in neurosyphilis patients and correlated with CSF protein concentration and CSF-VDRL titer...
2016: Scientific Reports
Marica Jandrić-Balen, Ivica Balen
During World War I, social and health conditions were difficult in Brod na Savi, as it stationed a large number of troops, and the military hospital was crowded with patients. With so many able-bodied men and breadwinners mobilised, the town's economy verged on the brink of poverty, but people managed to keep starvation at bay. The most common diseases among civilians were tuberculosis, malaria, intestinal infectious diseases, diphtheria, and venereal diseases, and in 1915 cholera broke out that lasted five months...
November 2015: Acta Medico-historica Adriatica: AMHA
John D Carter, Alan P Hudson
INTRODUCTION: Reactive arthritis (ReA) is an inflammatory disease that can follow gastrointestinal or genitourinary infections. The primary etiologic agent for post-venereal ReA is the bacterium Chlamydia trachomatis; its relative, C pneumoniae, has also been implicated in disease induction although to a lesser degree. Studies have indicated that the arthritis is elicited by chlamydiae infecting synovial tissue in an unusual biologic state designated persistence. We review clinical aspects, host-pathogen interactions, and treatments for the disease...
September 14, 2016: Expert Review of Clinical Immunology
Mónica Franco, Vanda Nogueira
PURPOSE: We report on a case of unilateral acute syphilitic posterior placoid chorioretinitis (ASPPC) with spontaneous resolution of the lesions, and discuss the role of an altered versus adequate immune response as the major pathogenic factor. METHODS: We describe a case of acute loss of visual acuity (VA) in the left eye (LE) in a 55-year-old healthy man. RESULTS: The patient presented with VA of 20/20 in the right eye (RE) and hand movements in the LE...
2016: GMS Ophthalmol Cases
Hans Mouser, Frank H Miller, Senta M Berggruen
History A 35-year-old man from the upper Midwest region of the United States who had no relevant medical history initially presented to an acute care clinic with multiple small tender skin lesions. His temperature was 38.1°C, and physical examination revealed several small fluctuant masses that were draining purulent material. Skin culture of one of the draining lesions was performed at this time, but there was no subsequent bacterial growth. A diagnosis of furunculosis was made, and Bactrim (sulfamethoxazole-trimethoprim; AR Scientific, Philadelphia, Pa) and a regimen of chlorhexidine washes were prescribed...
September 2016: Radiology
Jan F Gogarten, Ariane Düx, Verena J Schuenemann, Kathrin Nowak, Christophe Boesch, Roman M Wittig, Johannes Krause, Sébastien Calvignac-Spencer, Fabian H Leendertz
Treponema pallidum infections causing yaws disease and venereal syphilis are globally widespread in human populations, infecting hundreds of thousands and millions annually respectively; endemic syphilis is much less common and pinta has not been observed in decades. We discuss controversy surrounding the origin, evolution, and history of these pathogens in light of available molecular and anthropological evidence. These bacteria (or close relatives) seem to affect many wild African non-human primate species, though to date only a single non-human primate Treponema pallidum genome has been published, hindering detection of spillover events and our understanding of potential wildlife reservoirs...
August 4, 2016: Clinical Microbiology and Infection
Alessandro Ricardo Caruso da Cunha, Edgar Merchan-Hamann
OBJECTIVE: To estimate the prevalence and investigate the factors associated with syphilis in parturient women in Brazil. METHOD: This nationwide cross-sectional population-based study, with regional representativeness, was carried out with parturient women aged 15 to 49 years delivering babies in public healthcare system/partner maternity facilities between January 2010 and December 2011. Syphilis screening was based on a rapid treponemal test. Diagnostic confirmation was based on the Venereal Disease Research Laboratory (VDRL) test and additional treponemal tests...
December 2015: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
Francesco Drago, Giulia Ciccarese, Francesco Broccolo, Giulia Sartoris, Paola Stura, Susanna Esposito, Alfredo Rebora, Aurora Parodi
The objective of this study was to evaluate the efficacy of an enhanced treatment regimen for syphilis with the addition of doxycycline and ceftriaxone to the conventional benzathine penicillin G (BPG) treatment. Sixty-nine syphilis patients were recruited and were randomly assigned to two groups: group 1 (38 patients) received standard therapy and group 2 (31 patients) received the enhanced therapy. All patients were followed-up for at least 12 months. Patients underwent physical examination and serology every 6 months as well as echocardiography and neurological examination every year...
June 2016: Journal of Global Antimicrobial Resistance
Roger Tsobou, Pierre Marie Mapongmetsem, Patrick Van Damme
Medicinal Plants Used for Treating Reproductive Health Care Problems in Cameroon, Central Africa. Approximately 80% of the African population uses traditional plants to deal with health problems, basically because of their easy accessibility and affordability. This study was carried out to document indigenous knowledge of medicinal plants used by traditional healers and elders in the treatment of reproductive health care in the Bamboutos Division of the West Region in Cameroon, Central Africa. The research methods used included semi-structured interviews and participative field observations...
2016: Economic Botany
Mitchell Boyd-Moss, Sara Baratchi, Martina Di Venere, Khashayar Khoshmanesh
Microfluidic systems enable rapid diagnosis, screening and monitoring of diseases and health conditions using small amounts of biological samples and reagents. Despite these remarkable features, conventional microfluidic systems rely on bulky expensive external equipment, which hinders their utility as powerful analysis tools outside of research laboratories. 'Self-contained' microfluidic systems, which contain all necessary components to facilitate a complete assay, have been developed to address this limitation...
August 16, 2016: Lab on a Chip
Beata Ujvari, Anthony T Papenfuss, Katherine Belov
Cancer is an evolutionary and ecological process in which complex interactions between tumour cells and their environment share many similarities with organismal evolution. Tumour cells with highest adaptive potential have a selective advantage over less fit cells. Naturally occurring transmissible cancers provide an ideal model system for investigating the evolutionary arms race between cancer cells and their surrounding micro-environment and macro-environment. However, the evolutionary landscapes in which contagious cancers reside have not been subjected to comprehensive investigation...
July 2016: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
Costas Tsiamis, Georgia Vrioni, Effie Poulakou-Rebelakou, Vasiliki Gennimata, Mariana А Murdjeva, Athanasios Tsakris
The current study presents some aspects of syphilis in the Balkan Peninsula from the 19th century until the Interwar. Ever since the birth of modern Balkan States (Greece, Bulgaria, Turkey and Serbia), urbanization, poverty and the frequent wars have been considered the major factors conducive to the spread of syphilis. The measures against sex work and sexually transmitted diseases (STDs) were taken in two aspects, one medical and the other legislative. In this period, numerous hospitals for venereal diseases were established in the Balkan countries...
March 1, 2016: Folia Medica
M Costa-Silva, C Azevedo, F Azevedo, C Lisboa
BACKGROUND: Current treatment guidelines for early stages of syphilis are the same regardless of HIV serostatus. There is still controversy about the best treatment for syphilis in HIV patients and the current recommendations are based on limited data. OBJECTIVE: The primary goal of this study was to compare the serological response rates to a single dose vs. three weekly doses of benzathine penicillin G (BPG) in HIV-infected patients with early syphilis and to assess the adequacy of current recommendations...
June 22, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Milan Bjekić, Hristina Vlajinac, Sandra Šipetić-Grujičić
BACKGROUND: The Roma ethnic group is the largest and most marginalized minority in Europe, believed to be vulnerable to sexually transmitted infections. AIM: The purpose of the study was to investigate frequency and characteristics of gonorrhea and syphilis among the Roma population in Belgrade. METHODS: Data from the City Institute for Skin and Venereal Diseases to which all gonorrhea and syphilis cases are referred were analyzed. RESULTS: During the period of 2010-2014 sexually transmitted infections were more frequent among Roma than in rest of Belgrade population...
July 2016: Brazilian Journal of Infectious Diseases
Márcio Couto Henrique, Luiza Helena Miranda Amador
This article analyzes the fight against syphilis in Belém, capital of the Brazilian state of Pará, between 1921 and 1924. When Instituto de Profilaxia e Doenças Venéreas (Institute for Prophylaxis and Venereal Diseases) was founded, headed by Dr. Heraclídes de Souza Araújo, many restrictions were imposed on prostitution in a bid to make prostitutes partners in the city's sanitation reform. The documents produced by the institute and published in newspapers of the day reveal the various clashes that occurred between doctors, the civil police force, and prostitutes, highlighting the prostitutes' attitudes to state intervention in their activities...
January 26, 2016: História, Ciências, Saúde—Manguinhos
Ting Dai, Xinjun Wu, Shaona Zhou, Qianqiu Wang, Daning Li
BACKGROUND: Syphilis with ocular involvement has reemerged as a critical health problem. The aim of the present study was to explore the clinical manifestations and cerebrospinal fluid (CSF) status in ocular syphilis in human immunodeficiency virus (HIV)-negative patients. METHODS: The clinical records of patients with ocular syphilis presenting to the Shanghai Xuhui Central Hospital in the period from January 2011 to December 2012 were retrospectively reviewed...
2016: BMC Infectious Diseases
Dirk Roggenbuck, Maria Orietta Borghi, Valentina Somma, Thomas Büttner, Peter Schierack, Katja Hanack, Claudia Grossi, Caterina Bodio, Paolo Macor, Philipp von Landenberg, Francesco Boccellato, Michael Mahler, Pier Luigi Meroni
BACKGROUND: Antiphospholipid antibodies (aPL) can be detected in asymptomatic carriers and infectious patients. The aim was to investigate whether a novel line immunoassay (LIA) differentiates between antiphospholipid syndrome (APS) and asymptomatic aPL+ carriers or patients with infectious diseases (infectious diseases controls (IDC)). METHODS: Sixty-one patients with APS (56 primary, 22/56 with obstetric events only, and 5 secondary), 146 controls including 24 aPL+ asymptomatic carriers and 73 IDC were tested on a novel hydrophobic solid phase coated with cardiolipin (CL), phosphatic acid, phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylinositol, phosphatidylserine, beta2-glycoprotein I (β2GPI), prothrombin, and annexin V...
2016: Arthritis Research & Therapy
K Gayathri, S Vijay Shankar, S Venkatesan, S Kalaivani
A 50-year-old male presented with left lower abdominal pain, visible pulsation below xiphoid process, and tenderness in the left iliac fossa for the past 10 days. Chest X-ray revealed blunting of left cardiophrenic angle. Echocardiogram revealed descending thoracic aortic pseudoaneurysm. Contrast-enhanced computed tomography of the chest and abdomen revealed dissecting aneurysm of lower thoracic and upper abdominal aorta. Thoracoabdominal aortogram revealed erosion of D12 vertebra and infected aneurysm of adjacent thoracoabdominal aorta...
January 2016: Indian Journal of Sexually Transmitted Diseases
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