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https://www.readbyqxmd.com/read/28428052/opening-eyes-to-nanomedicine-where-we-are-challenges-and-expectations-on-nanotherapy-for-diabetic-retinopathy
#1
REVIEW
Elisa J Campos, António Campos, João Martins, António Francisco Ambrósio
People affected with ocular diseases will significantly increase over the next decades, and, consequently, a substantial increase in health costs is expected. Diabetic retinopathy is the most common chronic complication of diabetes. The treatment of eye diseases affecting the posterior segment, such as diabetic retinopathy, is quite challenging due to the anatomy, physiology and biochemistry of the eye. Therefore, the development of new therapeutics for posterior eye diseases has been a major focus of pharmaceutical research in the area of vision sciences...
April 17, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28357835/identification-of-world-health-organisation-ship-s-medicine-chest-contents-by-anatomical-therapeutic-chemical-atc-classification-codes
#2
Seyed Khorsow Tayebati, Giulio Nittari, Syed Sarosh Mahdi, Nicholas Ioannidis, Fabio Sibilio, Francesco Amenta
BACKGROUND: Ships should carry mandatory given amounts of medicinal products and basic first aid items, collectively known as the ship's medicine chest. Type and quantities of these products/items are suggested by the World Health Organisation (WHO) and regulated by individual flag states. In countries that lack national legislation, it is assumed that ships should follow WHO indications. An objective difficulty mainly involving vessels of international long-haul routes could be to recognise medicinal compounds obtained in other countries for replacing products used or expired...
2017: International Maritime Health
https://www.readbyqxmd.com/read/28269801/managing-formaldehyde-indoor-pollution-in-anatomy-pathology-departments
#3
Gabriele d'Ettorre, Mario Criscuolo, Mauro Mazzotta
BACKGROUND: Nearly eleven years have passed since the International Agency for Research on Cancer classified Formaldehyde (FA) as a known human carcinogen (group 1), yet the safety of anatomy pathology workers who are currently exposed to FA is still a matter of concern. OBJECTIVE: The purpose of this study was to evaluate the literature to discover which topics have been focused on and what the latest developments are in managing FA indoor pollution in anatomy pathology departments...
February 27, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28244444/nondestructive-imaging-of-the-internal-microstructure-of-vessels-and-nerve-fibers-in-rat-spinal-cord-using-phase-contrast-synchrotron-radiation-microtomography
#4
Jianzhong Hu, Ping Li, Xianzhen Yin, Tianding Wu, Yong Cao, Zhiming Yang, Liyuan Jiang, Shiping Hu, Hongbin Lu
The spinal cord is the primary neurological link between the brain and other parts of the body, but unlike those of the brain, advances in spinal cord imaging have been challenged by the more complicated and inhomogeneous anatomy of the spine. Fortunately with the advancement of high technology, phase-contrast synchrotron radiation microtomography has become widespread in scientific research because of its ability to generate high-quality and high-resolution images. In this study, this method has been employed for nondestructive imaging of the internal microstructure of rat spinal cord...
March 1, 2017: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/28229056/experimental-visualization-of-labyrinthine-structure-with-optical-coherence-tomography
#5
Saleh Mohebbi, Marjan Mirsalehi, Lüder-Alexander Kahrs, Tobias Ortmaier, Thomas Lenarz, Omid Majdani
INTRODUCTION: Visualization of inner ear structures is a valuable strategy for researchers and clinicians working on hearing pathologies. Optical coherence tomography (OCT) is a high-resolution imaging technology which may be used for the visualization of tissues. In this experimental study we aimed to evaluate inner ear anatomy in well-prepared human labyrinthine bones. MATERIALS AND METHODS: Three fresh human explanted temporal bones were trimmed, chemically decalcified with ethylenediaminetetraacetic acid (EDTA), and mechanically drilled under visual control using OCT in order to reveal the remaining bone shell...
January 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28220268/anterolateral-ligament-expert-group-consensus-paper-on-the-management-of-internal-rotation-and-instability-of-the-anterior-cruciate-ligament-deficient-knee
#6
REVIEW
Bertrand Sonnery-Cottet, Matthew Daggett, Jean-Marie Fayard, Andrea Ferretti, Camilo Partezani Helito, Martin Lind, Edoardo Monaco, Vitor Barion Castro de Pádua, Mathieu Thaunat, Adrian Wilson, Stefano Zaffagnini, Jacco Zijl, Steven Claes
Purpose of this paper is to provide an overview of the latest research on the anterolateral ligament (ALL) and present the consensus of the ALL Expert Group on the anatomy, radiographic landmarks, biomechanics, clinical and radiographic diagnosis, lesion classification, surgical technique and clinical outcomes. A consensus on controversial subjects surrounding the ALL and anterolateral knee instability has been established based on the opinion of experts, the latest publications on the subject and an exchange of experiences during the ALL Experts Meeting (November 2015, Lyon, France)...
February 20, 2017: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/28125816/comparative-anatomy-of-the-ovine-and-female-pelvis
#7
Iva Urbankova, Katarina Vdoviakova, Rita Rynkevic, Nikhil Sindhwani, Dries Deprest, Andrew Feola, Paul Herijgers, Ladislav Krofta, Jan Deprest
BACKGROUND: Pelvic organ prolapse affects half of vaginally parous women. Several animal models are used to study its pathophysiology and treatment. Sheep are interesting because they develop spontaneously prolapse with similar risk factors as women and can be used for vaginal surgery. This study describes ovine pelvis anatomy and compares it to women's pelvis to provide anatomical tools for translational researchers. METHODS: MRI, pelvic dissections, and histology were used for detailed macro- and microscopic analysis of relevant anatomical structures in 6 nulliparous ewes...
January 27, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28110279/walking-the-c4-pathway-past-present-and-future
#8
REVIEW
Robert T Furbank
The year 2016 marks 50 years since the publication of the seminal paper by Hatch and Slack describing the biochemical pathway we now know as C4 photosynthesis. This review provides insight into the initial discovery of this pathway, the clues which led Hatch and Slack and others to these definitive experiments, some of the intrigue which surrounds the international activities which led up to the discovery, and personal insights into the future of this research field. While the biochemical understanding of the basic pathways came quickly, the role of the bundle sheath intermediate CO2 pool was not understood for a number of years, and the nature of C4 as a biochemical CO2 pump then linked the unique Kranz anatomy of C4 plants to their biochemical specialization...
January 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28048518/th-cd-209-05-impact-of-spot-size-and-spacing-on-the-quality-of-robustly-optimized-intensity-modulated-proton-therapy-plans-for-lung-cancer
#9
W Liu, S Schild, J Chang, Z Liao, X Ding, Y Hu, J Shen, S Korte, N Sahoo, W Wong, M Herman, M Bues
PURPOSE: To investigate how spot size and spacing affect plan quality, especially, plan robustness and the impact of interplay effect, of robustly-optimized intensity-modulated proton therapy (IMPT) plans for lung cancer. METHODS: Two robustly-optimized IMPT plans were created for 10 lung cancer patients: (1) one for a proton beam with in-air energy dependent large spot size at isocenter (σ: 5-15 mm) and spacing (1.53σ); (2) the other for a proton beam with small spot size (σ: 2-6 mm) and spacing (5 mm)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048320/su-g-iep2-08-investigation-on-signal-detectability-in-volumetric-cone-beam-ct-images-with-anatomical-background
#10
M Han, J Baek
PURPOSE: To investigate the slice direction dependent detectability in cone beam CT images with anatomical background. METHODS: We generated 3D anatomical background images using breast anatomy model. To generate 3D breast anatomy, we filtered 3D Gaussian noise with a square root of 1/f(3) , and then assigned the attenuation coefficient of glandular (0.8cm(-1) ) and adipose (0.46 cm(-1) ) tissues based on voxel values. Projections were acquired by forward projection, and quantum noise was added to the projection data...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047650/th-ef-bra-09-direct-comparison-of-t2-based-respiratory-correlated-4dmri-reconstructed-from-simultaneous-internal-navigator-and-external-bellows
#11
G Li, D Olek, J Wei, M Kadbi, N Tyagi, K Zakian, J Mechalakos, J Deasy, M Hunt
PURPOSE: To optimize T2-based respiratory-correlated 4DMRI for motion simulation, we evaluated the image quality after 4D reconstruction based on the two respiratory surrogates acquired independently and concurrently during the same breathing period. METHODS: Both internal navigator and external bellows were employed simultaneously during a 4DMRI acquisition on seven volunteers scanned coronally and sagittally under an IRB-approved protocol. The navigator was positioned at the right diaphragm dome while the bellows was placed at the upper abdomen...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27851995/key-clinical-benefits-of-neuroimaging-at-7t
#12
Siegfried Trattnig, Elisabeth Springer, Wolfgang Bogner, Gilbert Hangel, Bernhard Strasser, Barbara Dymerska, Pedro Lima Cardoso, Simon Daniel Robinson
The growing interest in ultra-high field MRI, with more than 35.000 MR examinations already performed at 7T, is related to improved clinical results with regard to morphological as well as functional and metabolic capabilities. Since the signal-to-noise ratio increases with the field strength of the MR scanner, the most evident application at 7T is to gain higher spatial resolution in the brain compared to 3T. Of specific clinical interest for neuro applications is the cerebral cortex at 7T, for the detection of changes in cortical structure, like the visualization of cortical microinfarcts and cortical plaques in Multiple Sclerosis...
November 13, 2016: NeuroImage
https://www.readbyqxmd.com/read/27830064/evaluating-the-educational-environment-of-an-international-animal-model-based-wet-lab-course-for-undergraduate-students
#13
Michail Ch Sideris, Apostolos E Papalois, Thanos Athanasiou, Ioannis Dimitropoulos, Korina Theodoraki, Francois Sousa Dos Santos, Georgios Paparoidamis, Nikolaos Staikoglou, Dimitrios Pissas, Peter C Whitfield, Alexandros Rampotas, Savvas Papagrigoriadis, Vassilios Papalois, Georgios Zografos, Georgios Tsoulfas
BACKGROUND: Essential Skills in the management of Surgical Cases - ESMSC is an International Combined Applied Surgical Science and Wet Lab course aimed at the undergraduate level. ESMSC combines interactive basic science workshops and case-based learning, with basic surgical training modules (BST) on Ex Vivo and In Vivo swine model. In Vivo Dissections include more advanced modules i.e. Abdominal Anatomy Dissections and Cardiac Transplant. AIM: To evaluate the educational environment of a novel course, as well as to compare Medical students' perceptions across various groups...
December 2016: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/27778106/the-telencephalon-of-the-g%C3%A3-ttingen-minipig-cytoarchitecture-and-cortical-surface-anatomy
#14
Carsten R Bjarkam, Andreas N Glud, Dariusz Orlowski, Jens Christian H Sørensen, Nicola Palomero-Gallagher
During the last 20 years pigs have become increasingly popular in large animal translational neuroscience research as an economical and ethical feasible substitute to non-human primates. The anatomy of the pig telencephalon is, however, not well known. We present, accordingly, a detailed description of the surface anatomy and cytoarchitecture of the Göttingen minipig telencephalon based on macrophotos and consecutive high-power microphotographs of 15 μm thick paraffin embedded Nissl-stained coronal sections...
October 24, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27720956/individual-differences-shape-the-content-of-visual-representations
#15
Reshanne R Reeder
Visually perceiving a stimulus activates a pictorial representation of that item in the brain, but how pictorial is the representation of a stimulus in the absence of visual stimulation? Here I address this question with a review of the literatures on visual imagery (VI), visual working memory (VWM), and visual preparatory templates, all of which require activating visual information in the absence of sensory stimulation. These processes have historically been studied separately, but I propose that they can provide complimentary evidence for the pictorial nature of their contents...
October 7, 2016: Vision Research
https://www.readbyqxmd.com/read/27578418/a-new-system-for-classifying-root-and-root-canal-morphology
#16
REVIEW
H M A Ahmed, M A Versiani, G De-Deus, P M H Dummer
Knowledge of root and root canal morphology is a prerequisite for effective nonsurgical and surgical endodontic treatments. The external and internal morphological features of roots are variable and complex, and several classifications have been proposed to define the various types of canal configurations that occur commonly. More recently, improvements in nondestructive digital image systems, such as cone-beam and micro-computed tomography, as well as the use of magnification in clinical practice, have increased the number of reports on complex root canal anatomy...
August 31, 2016: International Endodontic Journal
https://www.readbyqxmd.com/read/27471895/endoscopic-versus-microscopic-microvascular-decompression-for-trigeminal-neuralgia-equivalent-pain-outcomes-with-possibly-decreased-postoperative-headache-after-endoscopic-surgery
#17
John Y K Lee, John T Pierce, Sukhmeet K Sandhu, Dmitriy Petrov, Andrew I Yang
OBJECTIVE Endoscopic surgery has revolutionized surgery of the ventral skull base but has not yet been widely adopted for use in the cerebellopontine angle. Given the relatively normal anatomy of the cerebellopontine angle in patients with trigeminal neuralgia (TN), the authors hypothesized that a fully endoscopic microvascular decompression (E-MVD) might provide pain outcomes equivalent to those of microscopic MVD (M-MVD) but with fewer complications. METHODS The authors conducted a single-institution, single-surgeon retrospective study with patients treated in the period of 2006-2013...
July 29, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27430435/functional-anatomy-of-the-spine
#18
REVIEW
Nikolai Bogduk
Among other important features of the functional anatomy of the spine, described in this chapter, is the remarkable difference between the design and function of the cervical spine and that of the lumbar spine. In the cervical spine, the atlas serves to transmit the load of the head to the typical cervical vertebrae. The axis adapts the suboccipital region to the typical cervical spine. In cervical intervertebrtal discs the anulus fibrosus is not circumferential but is crescentic, and serves as an interosseous ligament in the saddle joint between vertebral bodies...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27394520/revision-of-the-dwarf-cannibal-snails-nata-s-l-of-southern-africa-nata-s-s-and-natella-mollusca-gastropoda-rhytididae-with-description-of-three-new-species
#19
David G Herbert, Adnan Moussalli
This paper represents the second part of our revisionary studies on the rhytidid fauna of southern Africa. The species discussed belong to the taxon Nata s.l. in which we recognise two genus-level lineages, Nata s.s. and Natella with six (three new) and one species respectively. We update the species-level taxonomy extensively in the light of new molecular and morphological data, and provide a comprehensive revision of all species, including keys. Detailed comparative morphological observations are provided for the distal reproductive tract, pulmonary cavity, mantle edge, radula and suprapedal gland...
March 28, 2016: Zootaxa
https://www.readbyqxmd.com/read/27387907/feasibility-of-freehand-ultrasound-to-measure-anatomical-features-associated-with-deep-tissue-injury-risk
#20
Jonathan S Akins, Jaxon J Vallely, Patricia E Karg, Kara Kopplin, Amit Gefen, Prerna Poojary-Mazzotta, David M Brienza
Deep tissue injuries (DTI) are severe forms of pressure ulcers that start internally and are difficult to diagnose. Magnetic resonance imaging (MRI) is the currently preferred imaging modality to measure anatomical features associated with DTI, but is not a clinically feasible risk assessment tool. B-mode ultrasound (US) is proposed as a practical, alternative technology suitable for bedside or outpatient clinic use. The goal of this research was to confirm US as an imaging modality for acquiring measurements of anatomical features associated with DTI...
September 2016: Medical Engineering & Physics
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