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https://www.readbyqxmd.com/read/29778671/international-study-of-comparative-health-effectiveness-with-medical-and-invasive-approaches-ischemia-trial-rationale-and-design
#1
David J Maron, Judith S Hochman, Sean M O'Brien, Harmony R Reynolds, William E Boden, Gregg W Stone, Sripal Bangalore, John A Spertus, Daniel B Mark, Karen P Alexander, Leslee Shaw, Jeffrey S Berger, T Bruce Ferguson, David O Williams, Robert A Harrington, Yves Rosenberg
BACKGROUND: Prior trials comparing a strategy of optimal medical therapy with or without revascularization have not shown that revascularization reduces cardiovascular events in patients with stable ischemic heart disease (SIHD). However, those trials only included participants in whom coronary anatomy was known prior to randomization and did not include sufficient numbers of participants with significant ischemia. It remains unknown whether a routine invasive approach offers incremental value over a conservative approach with catheterization reserved for failure of medical therapy in patients with moderate or severe ischemia...
April 21, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29761459/mouse-genome-informatics-mgi-is-the-international-resource-for-information-on-the-laboratory-mouse
#2
MeiYee Law, David R Shaw
Mouse Genome Informatics (MGI, http://www.informatics.jax.org/ ) web resources provide free access to meticulously curated information about the laboratory mouse. MGI's primary goal is to help researchers investigate the genetic foundations of human diseases by translating information from mouse phenotypes and disease models studies to human systems. MGI provides comprehensive phenotypes for over 50,000 mutant alleles in mice and provides experimental model descriptions for over 1500 human diseases. Curated data from scientific publications are integrated with those from high-throughput phenotyping and gene expression centers...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29702268/vascular-entrapment-of-both-the-sciatic-and-pudendal-nerve-causing-persistent-sciatica-and-pudendal-neuralgia
#3
Ahmet Kale, Gulfem Basol, Taner Usta, Isa Cam
STUDY OBJECTIVE: To demonstrate the laparoscopic approach to malformed branches of the vessels entrapping the nerves of the sacral plexus. DESIGN: A step-by-step explanation of the surgery using video (instructive video). The Ethics Committee ruled that approval was not required for this video. SETTING: Derince Education and Research Hospital, Turkey PATIENT: : The 26-year-old patient who had failed the medical therapy, complained about numbness and burning pain on the right side of the vagina and pain radiating to the lower limb for approximately 36 months period...
April 24, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29674827/the-effect-of-different-geometric-shapes-and-angles-on-the-fracture-strength-of-ips-e-max-computer-aided-designed-ceramic-onlays-an-in-vitro-study
#4
Jonathan Chu, Vincent Bennani, John M Aarts, Nicholas Chandler, Bronwyn Lowe
Statement of Problem: The current ceramic onlay preparation techniques for cuspal areas involve the reduction of cusps following the cuspal anatomy and the removal of all sharp angulations. However, there is little research literature studying the effect of occlusal preparation angles. Furthermore, there is no recent literature on the effect of angulations on IPS e.max computer-aided designed (CAD) (e.max) ceramic onlays. Purpose: The purpose of this study is to investigate the effect of geometric cuspal angulation and different internal preparation angles on the fracture strength of e...
March 2018: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29652167/computational-phantoms-icrp-icru-and-further-developments
#5
M Zankl, J Becker, C Lee, W E Bolch, Y S Yeom, C H Kim
Phantoms simulating the human body play a central role in radiation dosimetry. The first computational body phantoms were based upon mathematical expressions describing idealised body organs. With the advent of more powerful computers in the 1980s, voxel phantoms have been developed. Being based on three-dimensional images of individuals, they offer a more realistic anatomy. Hence, the International Commission on Radiological Protection (ICRP) decided to construct voxel phantoms representative of the adult Reference Male and Reference Female for the update of organ dose coefficients...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29577230/neutron-based-computed-microtomography-pliobates-cataloniae-and-barberapithecus-huerzeleri-as-a-test-case-study
#6
Alessandro Urciuoli, Clément Zanolli, Josep Fortuny, Sergio Almécija, Burkhard Schillinger, Salvador Moyà-Solà, David M Alba
OBJECTIVES: High-resolution imaging of fossils with X-ray computed microtomography (μCT) has become a very powerful tool in paleontological research. However, fossilized bone, embedding matrix, and dental tissues do not always provide a distinct structural signal with X-rays. We demonstrate the benefits of high-resolution neutron radiation in three different specimens showing problematic contrasts with X-ray μCT. MATERIALS AND METHODS: We compare neutron with X-ray μCT scans of fossils from two Miocene catarrhines from the Vallès-Penedès Basin: the cranium (IPS58443...
March 25, 2018: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29573234/modeling-autism-in-non-human-primates-opportunities-and-challenges
#7
REVIEW
Hui Zhao, Yong-Hui Jiang, Yong Q Zhang
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social communication deficits and restricted, repetitive patterns of behavior. For more than a decade, genetically-modified, risk factor-induced, as well as naturally occurring rodent models for ASD have been used as the most predominant tools to dissect the molecular and circuitry mechanisms underlying ASD. However, the apparent evolutionary differences in terms of social behavior and brain anatomy between rodents and humans have become an issue of debate regarding the translational value of rodent models for studying ASD...
March 23, 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29561275/bodies-for-anatomy-education-in-medical-schools-an-overview-of-the-sources-of-cadavers-worldwide
#8
Juri L Habicht, Claudia Kiessling, Andreas Winkelmann
The International Federation of Associations of Anatomists (IFAA) recommended in 2012 that only donated bodies be used for anatomy teaching and research. However, in many countries around the world, anatomists still depend on bodies that do not stem from voluntary donations by the deceased, but rather are "unclaimed." A broad search of the literature was conducted to produce a baseline overview of the sources of cadavers used for anatomy teaching in undergraduate medical curricula on a global scale...
March 20, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29532521/consensus-guidelines-for-the-uniform-reporting-of-study-ethics-in-anatomical-research-within-the-framework-of-the-anatomical-quality-assurance-aqua-checklist
#9
Brandon Michael Henry, Jens Vikse, Przemyslaw Pekala, Marios Loukas, R Shane Tubbs, Jerzy A Walocha, D Gareth Jones, Krzysztof A Tomaszewski
Unambiguous reporting of a study's compliance with ethical guidelines in anatomical research is imperative. As such, clear, universal, and uniform reporting guidelines for study ethics are essential. In 2016, the International Evidence-Based Anatomy Working group in collaboration with international partners established reporting guidelines for anatomical studies, the Anatomical Quality Assurance (AQUA) Checklist. In this elaboration of the AQUA Checklist, consensus guidelines for reporting study ethics in anatomical studies are provided with in the framework of the AQUA Checklist...
May 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/29517517/the-anterolateral-complex-and-anterolateral-ligament-of-the-knee
#10
Volker Musahl, Elmar Herbst, Jeremy M Burnham, Freddie H Fu
The anterolateral structures of the knee have recently garnered considerable interest regarding their role in rotatory knee instability related to anterior cruciate ligament tears. Isolated anterior cruciate ligament reconstruction may not always restore rotatory stability of the knee. In these patients, additional procedures, such as lateral reconstruction or tenodesis, may be indicated. The anatomy of the anterolateral structures of the knee has been well described. Histologic and anatomic studies have reported conflicting findings regarding the presence of a discrete ligament...
April 15, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29460825/the-predictability-precision-of-superior-semicircular-canal-through-radiological-assessment-and-microanatomical-dissection
#11
Engin Kara, Kübra Öztürk, Ezgi Oktay, Vural Hamzaoğlu, Deniz Uzmansel, Yusuf Vayisoğlu, Hakan Özalp, Mehmet Farsak, Zeynep Cansu Aladağ, Tuğçe Pütürgeli, Can Mehmet Eti, Ahmet Dağtekin, Merve Türkegün, Derya Ümit Talas
OBJECTIVE: There is still ongoing research on the relationship of arcuate eminence (AE) and superior semicircular canal (SSC). We aimed to evaluate the precision of predictability of SSC through the morphology of AE via radiological means. MATERIALS AND METHODS: This investigation is performed on 12 dry skulls belonging to Mersin University Medical Faculty department of anatomy. Computed tomography (CT) assessment is performed with 0.5-mm-thin sections temporal bone algorithm on dry skulls which were marked with fixated copper wire by scotch tapes on the most prominent part of the middle fossa floor assuming the location of AE...
February 20, 2018: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29423228/does-formaldehyde-have-a-causal-association-with-nasopharyngeal-cancer-and-leukaemia
#12
Soon-Chan Kwon, Inah Kim, Jaechul Song, Jungsun Park
Background: The South Korean criteria for occupational diseases were amended in July 2013. These criteria included formaldehyde as a newly defined occupational carcinogen, based on cases of "leukemia or nasopharyngeal cancer caused by formaldehyde exposure". This inclusion was based on the Internal Agency for Research on Cancer classification, which classified formaldehyde as definite human carcinogen for nasopharyngeal cancer in 2004 and leukemia in 2012. Methods: We reviewed reports regarding the causal relationship between occupational exposure to formaldehyde in Korea and the development of these cancers, in order to determine whether these cases were work-related...
2018: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29393756/the-microneurosurgical-anatomy-legacy-of-albert-l-rhoton-jr-md-an-analysis-of-transition-and-evolution-over-50-years
#13
Toshio Matsushima, Ken Matsushima, Shigeaki Kobayashi, J Richard Lister, Jacques J Morcos
Dr. Albert L. Rhoton Jr. was a pioneer of the study of microneurosurgical anatomy. Championing this field over the past half century, he produced more than 500 publications. In this paper, the authors review his body of work, focusing on approximately 160 original articles authored by Rhoton and his microneuroanatomy fellows. The articles are categorized chronologically into 5 stages: 1) dawn of microneurosurgical anatomy, 2) study of basic anatomy for general neurosurgery, 3) study for skull base surgery, 4) study of the internal structures of the brain by fiber dissection, and 5) surgical anatomy dealing with new advanced surgical approaches...
February 2, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29333039/pharmacognostic-assesment-of-the-endemic-and-vulnerable-medicinal-climber-cayratia-pedata-lam-gagnep-var-glabra-gamble-and-its-antibacterial-activity
#14
S Sharmila, K Kalaichelvi, S M Dhivya, P Premamalini, P Abirami, G Jayanthi
Objective: The objective of this study is to evaluate a meticulous pharmacognostic cram is to supplement constructive information with regard to its identification, characterization, and standardization of endemic and endangered medicinal climber Cayratia pedata var. glabra and also screening the antibacterial activity of this climber. Materials and Methods: The morphological characters of study plant, microscopic examination of leaf powder, anatomy of young stem, physicochemical analysis of plant powder, extractive values, phytochemical analysis, powder with different chemical reagents, fluorescence analysis of plant powder, and other World Health Organization (WHO) recommended for standardization were analyzed...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29240039/an-overview-of-low-back-pain-and-occupational-exposures-to-whole-body-vibration-and-mechanical-shocks
#15
Massimo Bovenzi, Marianne Schust, Marcella Mauro
This paper offers an overview of the relation of low back pain (LBP) to occupational exposures to whole-body vibration (WBV) and mechanical shocks. LBP is a condition of multifactorial origin and is a very common health problem in the general population. Among occupational risk factors, epidemiological studies of driving occupations have provided evidence for strong associations between LBP and occupational exposures to WBV and mechanical shocks. Since it is hard to separate the contribution of WBV exposure to disorders in the lower back from that of other individual, ergonomic or psychosocial risk factors, a quantitative exposure-response relationship for WBV cannot be outlined precisely...
December 14, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/29223329/the-impact-of-psychosis-on-brain-anatomy-in-bipolar-disorder-a-structural-mri-study
#16
A Carlo Altamura, Eleonora Maggioni, Taj Dhanoa, Valentina Ciappolino, Riccardo A Paoli, Laura Cremaschi, Cecilia Prunas, Giulia Orsenigo, Elisabetta Caletti, Claudia M Cinnante, Fabio M Triulzi, Bernardo Dell'Osso, Lakshmi Yatham, Paolo Brambilla
BACKGROUND: Bipolar disorder (BD) is a major psychiatric illness characterized by heterogeneous symptoms including psychotic features. Up until now, neuroimaging studies investigating cerebral morphology in patients with BD have underestimated the potential impact of psychosis on brain anatomy in BD patients. In this regard, psychotic and non-psychotic BD may represent biologically different subtypes of the disorder, being possibly associated with specific cerebral features. METHODS: In the present study, magnetic resonance imaging (MRI) at 3T was used to identify the neuroanatomical correlates of psychosis in an International sample of BD patients...
November 29, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29191125/the-2017-aans-presidential-address-a-world-of-innovation
#17
Frederick A Boop
The 2016 scientific meeting of the American Association of Neurological Surgeons (AANS) focused on the theme "A World of Innovation." In his presidential address, 2016 AANS President Frederick Boop compared the historical development of the specialty of neurological surgery with that of the development of global communications. In the early years, general surgeons training in the United States would spend post-residency time abroad learning from surgical masters in Europe and other places. Since Harvey Cushing's day, neurosurgeons from around the world continue to travel abroad, with many now coming to America for training at centers of excellence...
December 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29163071/systematic-morphometry-of-catecholamine-nuclei-in-the-brainstem
#18
Domenico Bucci, Carla L Busceti, Maria T Calierno, Paola Di Pietro, Michele Madonna, Francesca Biagioni, Larisa Ryskalin, Fiona Limanaqi, Ferdinando Nicoletti, Francesco Fornai
Catecholamine nuclei within the brainstem reticular formation (RF) play a pivotal role in a variety of brain functions. However, a systematic characterization of these nuclei in the very same experimental conditions is missing so far. Tyrosine hydroxylase (TH) immune-positive cells of the brainstem correspond to dopamine (DA)-, norepinephrine (NE)-, and epinephrine (E)-containing cells. Here, we report a systematic count of TH-positive neurons in the RF of the mouse brainstem by using stereological morphometry...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29150310/zika-virus-in-french-polynesia-2013-14-anatomy-of-a-completed-outbreak
#19
REVIEW
Didier Musso, Hervé Bossin, Henri Pierre Mallet, Marianne Besnard, Julien Broult, Laure Baudouin, José Eduardo Levi, Ester C Sabino, Frederic Ghawche, Marion C Lanteri, David Baud
The Zika virus crisis exemplified the risk associated with emerging pathogens and was a reminder that preparedness for the worst-case scenario, although challenging, is needed. Herein, we review all data reported during the unexpected emergence of Zika virus in French Polynesia in late 2013. We focus on the new findings reported during this outbreak, especially the first description of severe neurological complications in adults and the retrospective description of CNS malformations in neonates, the isolation of Zika virus in semen, the potential for blood-transfusion transmission, mother-to-child transmission, and the development of new diagnostic assays...
November 14, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29136029/a-structural-review-of-foliar-glands-in-passiflora-l-passifloraceae
#20
REVIEW
Renata Cristina Cassimiro de Lemos, Delmira da Costa Silva, Gladys Flavia de Albuquerque Melo-de-Pinna
Extrafloral glands in Passifloraceae species have aroused the interest of many researchers because of their wide morphological diversity. The present work analyzed the foliar glands on 34 species of Passiflora from samples containing glands in the petiole and foliar blade fixed in 50% solution of formaldehyde-ethanol-acetic acid and stored in a 70% ethanol solution. For anatomical analyses, part of the material was embedded in Paraplast, longitudinally sectioned and double stained with safranin and astra blue...
2017: PloS One
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