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https://www.readbyqxmd.com/read/28210462/accuracy-of-a-new-rapid-antigen-detection-test-for-pulmonary-tuberculosis
#1
Rasoul Aliannejad, Ahmadreza Bahrmand, Hamidreza Abtahi, Mahnaz Seifi, Enayat Safavi, Farid Abdolrahimi, Shahriyar Shahriaran
BACKGROUND AND OBJECTIVES: Tuberculosis (TB) is a major problem in the world. Treatment and control of TB needs detection of the Mycobacterium tuberculosis (MT) in the proper samples. While smear doesn't have enough sensitivity, culture and PCR are expensive, time consuming and unavailable in many centers. Recent development of a rapid TB antigen detection test (PrTBK) at Pasteur Institute of Iran could give a simple way for diagnosis of TB in about two hours. In this test the antigen-antibody complex will change color when gold conjugated mouse anti-rabbit antibody detects specific MT cell wall antigen in suspected samples...
August 2016: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/28208160/quantitative-and-qualitative-profiles-of-circulating-monocytes-may-help-identifying-tuberculosis-infection-and-disease-stages
#2
Marco Pio La Manna, Valentina Orlando, Francesco Dieli, Paola Di Carlo, Antonio Cascio, Gilda Cuzzi, Fabrizio Palmieri, Delia Goletti, Nadia Caccamo
Tuberculosis (TB) is one of the most important cause of morbidity and death among infectious diseases, and continuous efforts are needed to improve diagnostic tools and therapy. Previous published studies showed that the absolute cells number of monocytes or lymphocytes in peripheral blood or yet the ratio of monocytes to lymphocytes displayed the ability to predict the risk of active TB. In the present study we evaluated the ratio of monocytes to lymphocytes variation and we also analyzed the ex-vivo expression of CD64 on monocytes as tools to identify biomarkers for discriminating TB stages...
2017: PloS One
https://www.readbyqxmd.com/read/28197340/phenotypic-and-genotypic-analysis-of-multidrug-resistant-mycobacterium-tuberculosis-isolates-from-sudanese-patients
#3
Solima M A Sabeel, Mohamed Ahmed Salih, Manasik Ali, Salah-Eldin El-Zaki, Nadir Abuzeid, Zeinab Abubaker Mohammed Elgadi, Hisham N Altayb, Asrar M A Elegail, Nuha Y Ibrahim, Bahaeldin K Elamin
Background. Currently, mutations in rpoB, KatG, and rrs genes and inhA promoter were considered to be involved in conferring resistance to rifampicin, isoniazid, and streptomycin in Mycobacterium tuberculosis (MTB). Objective. The aims of this study were to detect the prevalence of first-line tuberculosis (TB) drug resistance among a group of previously treated and newly detected TB patients, to determine the association between prevalence of multidrug resistance (MDR) and demographic information (age and sex), to explain genes correlated with MDR Mycobacterium tuberculosis, and to characterize MTB via 16S ribosomal RNA (16S rRNA) analysis...
2017: Tuberculosis Research and Treatment
https://www.readbyqxmd.com/read/28192214/immune-recognition-surface-construction-of-mycobacterium-tuberculosis-epitope-specific-antibody-responses-in-tuberculosis-patients-identified-by-peptide-microarrays
#4
REVIEW
Davide Valentini, Martin Rao, Giovanni Ferrara, Marc Perkins, Ernest Dodoo, Alimuddin Zumla, Markus Maeurer
BACKGROUND: Understanding of humoral immune responses in tuberculosis (TB) is gaining interest, since B cells and antibodies may be important in diagnosis as well as protective immune responses. High-content peptide microarrays (HCPM) are highly precise and reliable for gauging specific antibody responses to pathogens, as well as autoantigens. METHODS: We used a HCPM comprising epitopes spanning 154 proteins of Mycobacterium tuberculosis (M. tb) to gauge specific IgG antibody responses in sera of TB patients from Africa and South America...
February 9, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28185618/tuberculosis-a-world-health-organization-perspective
#5
Giovanni Sotgiu, Giorgia Sulis, Alberto Matteelli
Tuberculosis (TB) is an important cause of morbidity and mortality worldwide. The World Health Organization (WHO) has implemented and scaled-up three important global public health strategies (i.e., DOTS, Stop TB, and End TB) to improve the international scenario. Their epidemiological impact was relevant, as they decreased the number of potential new cases of disease and death. However, the emergence and spread of TB/HIV coinfection and multidrug-resistant TB have hindered the progress towards the elimination of TB by 2050...
January 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28182705/low-implementation-of-xpert-mtb-rif-among-hiv-tb-co-infected-adults-in-the-international-epidemiologic-databases-to-evaluate-aids-iedea-program
#6
Kate Clouse, Meridith Blevins, Mary Lou Lindegren, Marcel Yotebieng, Dung Thi Nguyen, Alfred Omondi, Denna Michael, Djimon Marcel Zannou, Gabriela Carriquiry, April Pettit
OBJECTIVE: Xpert MTB/RIF is recommended by the World Health Organization (WHO) as the initial tuberculosis (TB) diagnostic test in individuals suspected of HIV-associated TB. We sought to evaluate field implementation of Xpert among a cohort of HIV/TB co-infected individuals, including availability, utilization and outcomes. DESIGN: Observational cohort study (patient-level data) and cross-sectional study (site-level Xpert availability data). METHODS: Data were collected at 30 participating International epidemiologic Databases to Evaluate AIDS (IeDEA) sites in 18 countries from January 2012-January 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28179148/status-of-tuberculosis-services-in-indian-prisons
#7
REVIEW
Banuru Muralidhara Prasad, Bhadri Thapa, Sarabjit Singh Chadha, Anand Das, Entoor Ramachandra Babu, Subrat Mohanty, Sripriya Pandurangan, Jamhoih Tonsing
INTRODUCTION: Prisons are known to be a high risk environment for tuberculosis (TB) due to overcrowding, low levels of nutrition, poor infection control and lack of accessible healthcare services. India has nearly 1400 prisons housing 0.37 million inmates. However, information on, availability of diagnostic and treatment services for TB in the prison settings is limited. This study examined the availability of TB services in prisons of India. Simultaneously, prison inmates were screened for tuberculosis...
February 4, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28177961/new-concepts-in-understanding-latent-tuberculosis
#8
Claire E Dodd, Larry S Schlesinger
PURPOSE OF REVIEW: Mycobacterium tuberculosis (M.tb), the etiologic agent of tuberculosis, is a prominent global health threat because of the enormous reservoir of subclinical latent tuberculosis infection (LTBI). Current diagnostic approaches are limited in their ability to predict reactivation risk and LTBI is recalcitrant to antibiotic treatment. The present review summarizes recent advances in our ability to detect, treat and model LTBI as well as our understanding of bacterial physiology during latency...
February 7, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28177043/performance-of-a-molecular-assay-to-detect-mycobacterium-tuberculosis-complex-dna-in-clinical-specimens-multicenter-study-in-brazil
#9
Mirela Verza, Karen Barros Schmid, Regina Bones Barcellos, Natali Linck, Graziele Lima Bello, Daniel Scapin, Rosa Dea Sperhacke, Márcia Susana Nunes Silva, Claudia Wollheim, Martha Gabriela Celle Rivero, Afrânio Lineu Kritski, Leonides Rezende, Martha Maria Oliveira, Elis Regina Dalla Costa, Maria Lucia Rosa Rossetti
BACKGROUND: In high tuberculosis (TB) burden countries, there are few data on the performance of new molecular commercialised assays developed locally. OBJECTIVE: To evaluate the performance of a new molecular commercialised assay for TB diagnosis (Detect-TB) in three laboratories. METHODS: A total of 302 sputum samples from an equal number of patients with presumptive diagnosis of pulmonary tuberculosis (PTB) were submitted for routine smear microscopy, culture, and Detect-TB assay at three different sites in Brazil (the cities of Caxias do Sul, São Paulo and Canoas)...
February 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28173770/screening-for-genital-tuberculosis-in-a-limited-resource-country-case-report
#10
Sadie Namani, Emine Qehaja-Buçaj, Diellëza Namani
BACKGROUND: Screening for benign or malignant process of pelvis in young females is a challenge for a physician in a limited resource country. Tuberculosis should be always considered in the differential diagnosis of a pelvic mass in countries with high prevalence of tuberculosis. Negative results of analysis of peritoneal fluid for acid-fast staining, late cultures, and unavailability of new diagnostics methods such as polymerase chain reaction and adenosine deaminase of the aspirated fluid from peritoneal cavity can often result in invasive diagnostic procedures such as laparotomy...
February 7, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28170135/diagnostic-potential-of-interferon-gamma-release-assay-to-detect-latent-tuberculosis-infection-in-kidney-transplant-recipients
#11
Jameela Edathodu, Bright Varghese, Abdulrahman A Alrajhi, Mohammed Shoukri, Ahmad Nazmi, Hazem Elgamal, Hassan Aleid, Fahad Alrabiah, Aattia Ashraff, Ihab Mahmoud, Sahal Al-Hajoj
BACKGROUND: Latent tuberculosis (TB) infection (LTBI) is screened by using clinical assessment, tuberculin skin test (TST), chest radiography and recently by interferon-gamma release assays (IGRA). The objective of this study was to evaluate the diagnostic potential of QuantiFERON(®) -TB Gold In-Tube test (QFT) for diagnosing LTBI in patients planned for kidney transplantation. METHODS: All adult patients with end-stage renal disease, evaluated for kidney transplantation in a referral center from August 2008 till May 2013, were enrolled, after consenting in a prospective, observational, non-interventional study...
February 7, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28169940/role-of-posterior-stabilization-and-transpedicular-decompression-in-the-treatment-of-thoracic-and-thoracolumbar-tb-a-retrospective-evaluation
#12
Areena R D'souza, Bibhudendu Mohapatra, Murari L Bansal, Kalidutta Das
STUDY DESIGN: A retrospective study. OBJECTIVE: To evaluate the results of posterior pedicle-screw fixation with transpedicular decompression in 21 cases of thoracic and thoracolumbar spinal tuberculosis (TB) in terms of functional, neurological, and radiologic outcomes. SUMMARY OF BACKGROUND DATA: Spinal TB is predominantly an anterior disease that can lead to kyphotic deformity. Hence, anterior debridement and fusion was considered as the gold standard...
February 6, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28167256/turning-the-tide-against-tuberculosis
#13
Nesri Padayatchi, Naressa Naidu, Gerald Friedland, Kasavan Naidoo, Francesca Conradie, Kogieleum Naidoo, Max Roe O'Donnell
Despite affecting men, women and children for millennia, tuberculosis (TB) is the most neglected disease. In contrast, the global response to HIV has reached a defining moment. By uniting efforts, promptly integrating major scientific findings for both treatment and prevention, and scaling up services, the once inconceivable end to the HIV epidemic may no longer be an illusion. "The world has made defeating AIDS a top priority. This is a blessing. But TB remains ignored" - Nelson Mandela. While there is no doubt that revolutionary diagnostics, and new and repurposed drugs have provided some hope in the fight against TB, it is evident that scientific advances on their own are inadequate to achieve the World Health Organisation's ambitious goal to end TB by 2035...
February 3, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28166912/tuberculosis-knowledge-and-attitude-in-aspiring-doctors-and-nurses-is-it-time-for-our-tb-teaching-methods-to-evolve
#14
Preetam Rajgopal Acharya, Monalisa D'Souza, Ramesh Chandra Sahoo
BACKGROUND: India accounts for nearly 24% of all the new tuberculosis (TB) cases globally. A good core knowledge and a positive outlook towards TB patients among our aspiring doctors and nurses are necessities for India to meet the Sustainable Development Goals (SDG) proposed by the WHO as a part of its post-2015 global TB strategy and to successfully combat the newer challenges posed by this disease in the future. AIMS: To evaluate knowledge related to transmission, prevention and treatment of tuberculosis amongst medical and nursing students...
January 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28166728/why-being-an-expert-despite-xpert-remains-crucial-for-children-in-high-tb-burden-settings
#15
Jason M Bacha, Katherine Ngo, Petra Clowes, Heather R Draper, Elias N Ntinginya, Andrew DiNardo, Chacha Mangu, Issa Sabi, Bariki Mtafya, Anna M Mandalakas
BACKGROUND: As access to Xpert expands in high TB-burden settings, its performance against clinically diagnosed TB as a reference standard provides important insight as the majority of childhood TB is bacteriologically unconfirmed. We aim to describe the characteristics and outcomes of children with presumptive TB and TB disease, and assess performance of Xpert under programmatic conditions against a clinical diagnosis of TB as a reference standard. METHODS: Retrospective review of children evaluated for presumptive TB in Mbeya, Tanzania...
February 6, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28162875/diagnosis-of-spinal-lesions-using-heuristic-and-pharmacokinetic-parameters-measured-by-dynamic-contrast-enhanced-mri
#16
Ning Lang, Huishu Yuan, Hon J Yu, Min-Ying Su
RATIONALE AND OBJECTIVES: This study aimed to evaluate the diagnostic performance of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in differentiation of four spinal lesions by using heuristic and pharmacokinetic parameters analyzed from DCE signal intensity time course. MATERIALS AND METHODS: DCE-MRI of 62 subjects with confirmed myeloma (n = 9), metastatic cancer (n = 22), lymphoma (n = 7), and inflammatory tuberculosis (TB) (n = 24) in the spine were analyzed retrospectively...
February 2, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28162099/cost-effectiveness-of-active-case-finding-of-household-contacts-of-pulmonary-tuberculosis-patients-in-a-low-hiv-tuberculosis-endemic-urban-area-of-lima-peru
#17
L Shah, M Rojas, O Mori, C Zamudio, J S Kaufman, L Otero, E Gotuzzo, C Seas, T F Brewer
We compared the cost-effectiveness (CE) of an active case-finding (ACF) programme for household contacts of tuberculosis (TB) cases enrolled in first-line treatment to routine passive case-finding (PCF) within an established national TB programme in Peru. Decision analysis was used to model detection of TB in household contacts through: (1) self-report of symptomatic cases for evaluation (PCF), (2) a provider-initiated ACF programme, (3) addition of an Xpert MTB/RIF diagnostic test for a single sputum sample from household contacts, and (4) all strategies combined...
February 6, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28160362/globalization-of-pediatric-transplantation-the-risk-of-tuberculosis-or-not-tuberculosis
#18
Mignon McCulloch, Philana Ling Lin
The risk of TB among pediatric SOT recipients increases as the globalization of medical care continues to broaden. Unlike adults, children and especially infants are more susceptible to TB as a complication after transplantation. Little data exist regarding the true incidence of TB and the optimal risk-based management of this very vulnerable population. Here, we highlight the theoretical and practical issues that complicate the management of these patients and pose some questions that should be addressed when managing these patients...
February 3, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28159630/improved-method-for-collection-of-sputum-for-tuberculosis-testing-to-ensure-adequate-sample-volumes-for-molecular-diagnostic-testing
#19
Mark Fisher, Tania Dolby, Shireen Surtie, Gaironesa Omar, Nchimunya Hapeela, Debby Basu, Abby DeWalt, David Kelso, Mark Nicol, Sally McFall
The quality and quantity of sputum collected has an important impact on the laboratory diagnosis of pulmonary TB. We conducted a pilot study to assess a new collection cups for the collection of sputum for the diagnosis of pulmonary tuberculosis. The pilot study utilized the standard collection cup in South Africa demonstrating a mean collection volume of 2.86±2.36SDml for 198 samples; 19% of the specimens contained <1ml and 12% contained >5ml. We designed and tested two novel sputum cups with a narrow bottom section and clear minimum and maximum markings to allow patients and clinicians to know whether sufficient sputum volume has been produced...
January 31, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28159608/safety-and-efficacy-of-the-c-tb-skin-test-to-diagnose-mycobacterium-tuberculosis-infection-compared-with-an-interferon-%C3%AE-release-assay-and-the-tuberculin-skin-test-a-phase-3-double-blind-randomised-controlled-trial
#20
Morten Ruhwald, Henrik Aggerbeck, Rafael Vázquez Gallardo, Søren T Hoff, José I Villate, Bettine Borregaard, José A Martinez, Ingrid Kromann, Antón Penas, Luis L Anibarro, Maria Luiza de Souza-Galvão, Francisca Sánchez, Jose Ángel Rodrigo-Pendás, Antoni Noguera-Julian, Xavier Martínez-Lacasa, Maria Victoria Tuñez, Virginia Leiro Fernández, Joan P Millet, Antonio Moreno, Nazaret Cobos, José M Miró, Llanos Roldan, Angels Orcau, Peter Andersen, Joan A Caylá
BACKGROUND: Targeted screening and treatment of Mycobacterium tuberculosis infection substantially reduces the risk of developing active tuberculosis. C-Tb (Statens Serum Institute, Copenhagen, Denmark) is a novel specific skin test based on ESAT-6 and CFP10 antigens. We investigated the safety and diagnostic potential of C-Tb compared with established tests in the contact-tracing setting. METHODS: Negative controls, close contacts, occasional contacts, and patients with active pulmonary tuberculosis were enrolled at 13 centres in Spain...
January 31, 2017: Lancet Respiratory Medicine
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