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BK hemorrhagic cystitis

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https://www.readbyqxmd.com/read/27862740/poor-immune-reconstitution-is-associated-with-symptomatic-bk-polyomavirus-viruria-in-allogeneic-stem-cell-transplant-recipients
#1
Ala Abudayyeh, Amir Hamdi, Maen Abdelrahim, Heather Lin, Valda D Page, Gabriela Rondon, Borje S Andersson, Aimaz Afrough, Charles S Martinez, Jeffrey J Tarrand, Dimitrios P Kontoyiannis, David Marin, A Osama Gaber, Betul Oran, Roy F Chemaly, Sairah Ahmed, Islam Abudayyeh, Amanda Olson, Roy Jones, Uday Popat, Richard E Champlin, Elizabeth J Shpall, Katayoun Rezvani
BACKGROUND: BK polyomavirus (BKPyV) infections are known indicators of immune suppression in hematopoietic stem cell transplant (HSCT) recipients; they can lead to hemorrhagic cystitis, ureteral stenosis, renal dysfunction, and prolonged hospital stays. In this study, we determined transplant-associated variables and immune parameters that can predict for the risk of BKPyV viruria. We hypothesized that BKPyV infection is a marker of poor immune recovery. METHODS: We analyzed all engrafted patients undergoing first allogeneic HSCT at MD Anderson Cancer Center in Houston between January 2004 and December 2012...
November 14, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/27793653/urologic-outcomes-of-children-with-hemorrhagic-cystitis-after-bone-marrow-transplant-at-a-single-institution
#2
Jason K Au, Christopher Graziano, Rodolfo A Elizondo, Sheila Ryan, David R Roth, Chester J Koh, Edmond T Gonzales, Duong T Tu, Nicolette Janzen, Swati Naik, Abhishek Seth
OBJECTIVE: To analyzed clinical outcomes and the risk factors associated with genitourinary (GU) morbidity and mortality in children who present with Hemorrhagic Cystitis (HC) after bone marrow transplantation (BMT). METHODS: A retrospective chart review of patients with HC who had undergone BMT at a single pediatric hospital from 2008-2015 was conducted. Demographic data, severity of hematuria, HC management, and mortality were analyzed. Bivariate analysis and binary logistic regression were performed to identify risk factors...
October 25, 2016: Urology
https://www.readbyqxmd.com/read/27772622/bk-and-other-polyomaviruses-in-kidney-transplantation
#3
Jennifer Trofe-Clark, Deirdre Sawinski
For more than 40 years, polyomaviruses (BK virus and JC virus) have been known to cause disease in human beings. Recently, 11 new polyomaviruses were discovered. However, the majority of these viruses are rare in renal transplant recipients and BK and JC viruses remain the most important polyomaviruses to impact this population. BK virus presents as BK virus nephropathy and has, in rare instances, been associated with hemorrhagic cystitis or ureteral strictures. JC virus can cause progressive multifocal leukoencephalopathy or nephropathy in this population as well, but is uncommon...
September 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27705933/definition-and-characterization-of-novel-hla-a02-restricted-cd8-t-cell-epitopes-derived-from-jcv-polyomavirus-with-clinical-relevance
#4
Jiju Mani, Lei Wang, Angela G Hückelhoven, Anita Schmitt, Alma Gedvilaite, Nan Jin, Christian Kleist, Anthony D Ho, Michael Schmitt
Human JC and BK polyomaviruses (JCV/BKV) can establish a latent infection without any clinical symptoms in healthy individuals. In immunocompromised hosts infection or reactivation of JCV and BKV can cause lethal progressive multifocal leukoencephalopathy (PML) and hemorrhagic cystitis, respectively. Vaccination with JCV/BKV derived antigen epitope peptides or adoptive transfer of virus-specific T cells would constitute an elegant approach to clear virus-infected cells. Furthermore, donor leukocyte infusion (DLI) is another therapeutic approach which could be helpful for patients with JCV/BKV infections...
October 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27696719/bk-polyomavirus-encephalitis-in-a-patient-with-thrombotic-microangiopathy-after-an-allogeneic-hematopoietic-stem-cell-transplant
#5
Jae-Bum Jun, Yunsuk Choi, Hawk Kim, Sun Ho Lee, Joseph Jeong, Jiwon Jung
To date, only 1 case of BK polyomavirus (BKPyV) encephalitis combined with transplant-associated thrombotic microangiopathy has been reported in a hematopoietic stem cell transplantation (HCT) recipient. We report the case of a HCT recipient who developed thrombotic microangiopathy and subsequent BKPyV encephalitis. She died despite treatment with cidofovir, ciprofloxacin, and intravenous immunoglobulin without improvement in mental status. Early suspicion of BKPyV encephalitis in a HCT recipient presenting with altered mentality and hemorrhagic cystitis is important...
October 1, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/27595281/patterns-of-infection-and-infection-related-mortality-in-patients-with-steroid-refractory-acute-graft-versus-host-disease
#6
I García-Cadenas, I Rivera, R Martino, A Esquirol, P Barba, S Novelli, G Orti, J Briones, S Brunet, D Valcarcel, J Sierra
This study aimed to characterize the incidence, etiology and outcome of infectious episodes in patients with steroid refractory acute GvHD (SR-GvHD). The cohort included 127 adults treated with inolimomab (77%) or etanercept (23%) owing to acute 2-4 SR-GvHD, with a response rate of 43% on day +30 and a 4-year survival of 15%. The 1-year cumulative incidences of bacterial, CMV and invasive fungal infection were 74%, 65% and 14%, respectively. A high rate (37%) of enterococcal infections was observed. Twenty patients (15...
September 5, 2016: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27094950/bk-virus-hemorrhagic-cystitis-following-allogeneic-stem-cell-transplantation-clinical-characteristics-and-utility-of-leflunomide-treatment
#7
Young Hoon Park, Joo Han Lim, Hyeon Gyu Yi, Moon Hee Lee, Chul Soo Kim
: BK virus-hemorrhagic cystitis (BKV-HC) is a potential cause of morbidity and mortality in patients having undergone allogeneic stem cell transplantation (Allo-SCT). We analyzed the clinical features of BKV-HC following Allo-SCT and reported the utility of leflunomide therapy for BKV-HC. MATERIALS AND METHODS: From January 2005 to June 2014, among the 69 patients underwent Allo-SCT in our institution, the patients who experienced BKV-HC were investigated retrospectively...
April 18, 2016: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/26926552/risk-factors-associated-with-severity-and-outcomes-in-pediatric-patients-with-hemorrhagic-cystitis
#8
Derrick Johnston, Elleson Schurtz, Elizabeth Tourville, Tamekia Jones, Allison Boemer, Dana Giel
PURPOSE: Hemorrhagic cystitis is a complication of treatment of pediatric cancer with considerable variation in severity and morbidity. This study presents an analysis of hemorrhagic cystitis severity and treatment outcomes in a large pediatric population. MATERIALS AND METHODS: Patients with hemorrhagic cystitis treated at St. Jude Children's Research Hospital® were identified from 1990 to 2010. Demographic data were gathered along with information pertaining to initial primary diagnosis, hemorrhagic cystitis diagnosis and treatment, and mortality...
April 2016: Journal of Urology
https://www.readbyqxmd.com/read/26904123/myeloablative-conditioning-with-pbsc-grafts-for-t-cell-replete-haploidentical-donor-transplantation-using-posttransplant-cyclophosphamide
#9
REVIEW
Scott R Solomon, Melhem Solh, Lawrence E Morris, H Kent Holland, Asad Bashey
Relapse is the main cause of treatment failure after nonmyeloablative haploidentical transplant (haplo-HSCT). In an attempt to reduce relapse, we have developed a myeloablative (MA) haplo-HSCT approach utilizing posttransplant cyclophosphamide (PT/Cy) and peripheral blood stem cells as the stem cell source. We summarize the results of two consecutive clinical trials, using a busulfan-based (n = 20) and a TBI-based MA preparative regimen (n = 30), and analyze a larger cohort of 64 patients receiving MA haplo-HSCT...
2016: Advances in Hematology
https://www.readbyqxmd.com/read/26902502/bk-virus-associated-hemorrhagic-cystitis-after-allogeneic-hematopoietic-stem-cell-transplantation-in-the-pediatric-population
#10
Pablo Pérez-Huertas, Margarita Cueto-Sola, Paloma Escobar-Cava, José María Fernández-Navarro, Carmela Borrell-García, Asunción Albert-Marí, Eduardo López-Briz, José Luis Poveda-Andrés
OBJECTIVE: To study the incidence, risk factors, and treatment of hemorrhagic cystitis secondary to BK-virus reactivation (HC-BKV) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in the pediatric population. METHODS: Case-control study in which all pediatric patients (0-18 years) who underwent allo-HSCT from September 2009 to January 2014 were followed. RESULTS: Twenty-nine patients underwent an allo-HSCT. The median age was 9 years (range = 6 months to 15 years), 61% male...
February 22, 2016: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
https://www.readbyqxmd.com/read/26901486/caveolin-and-clathrin-independent-entry-of-bkpyv-into-primary-human-proximal-tubule-epithelial-cells
#11
Linbo Zhao, Anthony T Marciano, Courtney R Rivet, Michael J Imperiale
BK polyomavirus (BKPyV) is a human pathogen that causes polyomavirus-associated nephropathy and hemorrhagic cystitis in transplant patients. Gangliosides and caveolin proteins have previously been reported to be required for BKPyV infection in animal cell models. Recent studies from our lab and others, however, have indicated that the identity of the cells used for infection studies can greatly influence the behavior of the virus. We therefore wished to re-examine BKPyV entry in a physiologically relevant primary cell culture model, human renal proximal tubule epithelial cells...
May 2016: Virology
https://www.readbyqxmd.com/read/26898668/successful-treatment-with-intravesical-cidofovir-for-virus-associated-hemorrhagic-cystitis-after-allogeneic-hematopoietic-stem-cell-transplantation-a-case-report-and-a-review-of-the-literature
#12
Maki Sakurada, Tadakazu Kondo, Masayuki Umeda, Hiroshi Kawabata, Kouhei Yamashita, Akifum Takaori-Kondo
Virus-associated hemorrhagic cystitis (VAHC) is a formidable complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The standard management of severe VAHC after allo-HSCT has not been established. Intravenous administration of cidofovir (CDV), an acyclic nucleoside analogue with broad-spectrum activity against DNA viruses, has been reported to be effective for VAHC, but it can cause severe renal toxicity. Here we report four cases who achieved clinical responses with intravesical instillation of CDV for severe VAHC after allo-HSCT...
July 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/26895217/the-noninvasive-urinary-polyomavirus-haufen-test-predicts-bk-virus-nephropathy-in-children-after-hematopoietic-cell-transplantation-a-pilot-study
#13
Benjamin L Laskin, Harsharan K Singh, Ulf H Beier, Taylor Moatz, Susan L Furth, Nancy Bunin, David Witte, Jens Goebel, Stella M Davies, Christopher Dandoy, Sonata Jodele, Volker Nickeleit
BACKGROUND: After hematopoietic cell transplantation (HCT), polyoma-BK virus is associated with hemorrhagic cystitis and also with polyomavirus nephropathy (PVN). However, the true burden of post-HCT PVN is unknown because kidney biopsies are avoided due to their bleeding risk. The novel, noninvasive urinary PV-Haufen test detects PVN in kidney transplant recipients with greater than 95% positive/negative predictive values. We hypothesized that the detection of PV-Haufen in voided urine samples-a positive PV-Haufen test-was also clinically significant after HCT...
October 2016: Transplantation
https://www.readbyqxmd.com/read/26818211/the-first-case-of-acute-unilateral-pan-ureteritis-caused-by-bk-polyomavirus-in-an-allogeneic-stem-cell-transplant-patient
#14
M Nigo, D Marin, V E Mulanovich
Several cases of ureteral obstruction have been reported in stem cell transplant (SCT) patients; however, they were bilateral and concomitant with or preceded by hemorrhagic cystitis. We describe, to our knowledge, a first case of acute unilateral pan-ureteritis caused by BK polyomavirus (BKPyV) in an SCT patient. This case may represent an early phase of BKPyV reactivation. BKPyV infection should be considered as a potential cause of acute unilateral ureteritis even among SCT recipients.
April 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/26809742/studies-of-human-polyomaviruses-with-hpyv7-bkpyv-and-jcpyv-present-in-urine-of-allogeneic-hematopoietic-stem-cell-transplanted-patients-with-or-without-hemorrhagic-cystitis
#15
J Franzén, T Ramqvist, G Bogdanovic, N Grün, J Mattson, T Dalianis
BACKGROUND: BK polyomavirus (BKPyV) can cause hemorrhagic cystitis (HC) in allogeneic hematopoietic stem cell transplant (allo-HSCT) patients and polyomavirus-associated nephritis in renal transplant patients, while JC polyomavirus (JCPyV) can generate progressive multifocal leukoencephalopathy in immunocompromised individuals. Since 2007, additional human polyomaviruses (HPyVs) have been identified. In this study, we examined the urines of allo-HSCT patients for possible presence of polyomaviruses BKPyV, JCPyV, KIPyV, WUPyV, MCPyV, HPyV6, HPyV7, TSPyV, HPyV9, and HPyV10 (MWPyV)...
April 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/26792012/reactivation-of-polyomavirus-in-the-genitourinary-tract-is-significantly-associated-with-severe-gvhd-and-oral-mucositis-following-allogeneic-stem-cell-transplantation
#16
Lisa Peterson, Helmut Ostermann, Michael Fiegl, Johanna Tischer, Gundula Jaeger, Christina T Rieger
PURPOSE: BK-virus and JC-virus are the most common polyomaviridae associated with hemorrhagic cystitis in the allogeneic transplant setting. Hemorrhagic cystitis and symptomatic viruria caused by these viruses are a major cause of morbidity in patients undergoing allogeneic stem cell transplantation. METHODS: We performed a retrospective evaluation on a highly uniform study population of 73 patients receiving allogeneic stem cell transplantation. Patients were treated according to the FLAMSA-RIC-protocol, and were examined for the incidence of BK-/JC-viruria and late-onset BK-positive hemorrhagic cystitis within a two-year period...
August 2016: Infection
https://www.readbyqxmd.com/read/26771744/simultaneous-bk-polyomavirus-bkpyv-associated-nephropathy-and-hemorrhagic-cystitis-after-living-donor-kidney-transplantation
#17
Ilkka Helanterä, Hans H Hirsch, Marion Wernli, Fernanda Ortiz, Marko Lempinen, Anne Räisänen-Sokolowski, Eeva Auvinen, Laura Mannonen, Irmeli Lautenschlager
BK polyomavirus (BKPyV) commonly reactivates after kidney transplantation, and can cause polyomavirus-associated nephropathy (PyVAN), whereas after allogeneic stem cell transplantation the most frequent manifestation of BKPyV is polyomavirus-associated hemorrhagic cystitis (PyVHC). Despite high-level BKPyV replication in both, the pathogenesis and manifestation of both BKPyV entities appears to differ substantially. We describe an unusual case of simultaneous PyVAN and PyVHC presenting with acute symptoms in a BKPyV-IgG positive recipient eight months after kidney transplantation from a haploidentical living donor, who was BKPyV-IgG negative...
March 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/26742970/hemorrhagic-cystitis-requiring-bladder-irrigation-is-associated-with-poor-mortality-in-hospitalized-stem-cell-transplant-patients
#18
Valary T Raup, Aaron M Potretzke, Brandon J Manley, John A Brockman, Sam B Bhayani
PURPOSE: To evaluate the overall prognosis of post-stem cell transplant inpatients who required continuous bladder irrigation (CBI) for hematuria. MATERIALS AND METHODS: We performed a retrospective analysis of adult stem cell transplant recipients who received CBI for de novo hemorrhagic cystitis as inpatients on the bone marrow transplant service at Washington University from 2011-2013. Patients who had a history of genitourinary malignancy and/or recent surgical urologic intervention were excluded...
November 2015: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/26718666/cidofovir-in-the-treatment-of-bk-virus-associated-hemorrhagic-cystitis-after-allogeneic-hematopoietic-stem-cell%C3%A2-transplantation
#19
Michael Philippe, Florence Ranchon, Lila Gilis, Vérane Schwiertz, Nicolas Vantard, Florence Ader, Hélène Labussiere-Wallet, Xavier Thomas, Franck-Emmanuel Nicolini, Eric Wattel, Sophie Ducastelle-Leprêtre, Fiorenza Barraco, Laure Lebras, Gilles Salles, Mauricette Michallet, Catherine Rioufol
After allogeneic hematopoietic stem cell transplantation (HSCT), BK virus-associated hemorrhagic cystitis (BKV-HC) is a common complication. Although supportive measures have been the standard of care for many years, several studies suggested the efficacy of cidofovir. The aim of this study was to assess the safety profile and efficacy of cidofovir. A retrospective study was conducted on all patients treated with cidofovir in our HSCT unit between March 2011 and May 2013. Data for efficacy (partial [PR] or complete response [CR]), prescription (dose, frequency, number of doses, and administration route), and toxicity were collected from published reports and medical files...
April 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/26543712/correlation-of-the-clinical-parameters-with-sonographic-findings-of-hemorrhagic-cystitis-in-pediatric-hematooncology-patients
#20
In Kyung Youn, Soo Ah Im, Jae Wook Lee, Nak Gyun Chung, Bin Cho
To find a relationship between clinical and sonographic appearance of hemorrhagic cystitis (HC) in pediatric hematooncology patients. Clinical and sonographic findings of 31 children (M:F = 18:13; mean age, 12.7 years) with HC in pediatric hematooncology patients were reviewed. For each patient, the onset of HC after transplantation, use of bladder-toxic agent, presence of BK viruria, and duration of disease were reviewed. Sonographic findings including bladder wall thickness (BWT), the type of bladder wall thickening (nodular vs...
2015: SpringerPlus
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