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https://www.readbyqxmd.com/read/29222360/antiviral-treatment-of-bk-virus-viremia-after-kidney-transplantation
#1
REVIEW
Andrew D Santeusanio, Benjamin E Lukens, Judy Eun
PURPOSE: The various antiviral treatment options in the management of BK virus (BKV) viremia and BKV-associated nephropathy (BKVAN) are reviewed. SUMMARY: Review of the PubMed database from 1990 to 2016 for all English language case series, cohort studies, and randomized controlled trials detailing antiviral treatment of BKV viremia or BKVAN in kidney transplant recipients returned only 16 published reports. The majority of these reports were based on small case series or protocol-based cohort studies, with no prospective head-to-head data and only modest benefit reported for cidofovir, leflunomide, i...
December 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29106916/bk-polyomavirus-genotypes-ia-and-ib1-exhibit-different-biological-properties-in-renal-transplant-recipients
#2
Rafael B Varella, Ana Carolina J Zalona, Nuria C Diaz, Mariano G Zalis, Guilherme Santoro-Lopes
BK polyomavirus (BKV) is an opportunist agent associated with nephropathy (BKVAN) in 1-10% of kidney transplant recipients. BKV is classified into genotypes or subgroups according to minor nucleotidic variations with unknown biological implications. Studies assessing the possible association between genotypes and the risk of BKVAN in kidney transplant patients have presented conflicting results. In these studies, genotype Ia, which is highly prevalent in Brazil, was less frequently found and, thus, comparative data on the biological properties of this genotype are lacking...
October 26, 2017: Virus Research
https://www.readbyqxmd.com/read/29104861/graft-loss-among-renal-transplant-recipients-with-early-reduction-of-immunosuppression-for-bk-viremia
#3
Marwan M Azar, Roland Assi, Aziz K Valika, David B Banach, Isaac E Hall, Marie-Louise Landry, Maricar F Malinis
AIM: To review the incidence of graft loss and acute rejection among renal transplant recipients with early reduction of immunosuppression for BK viremia. METHODS: We performed a retrospective analysis of consecutive de-novo kidney-only transplants from January 2009 to December 2012 to evaluate the incidence of Polyoma-virus associated nephropathy (PyVAN). Recipient plasma was screened for BKV DNA via quantitative polymerase chain reaction (PCR) at months 1, 3, 6, 9 and 12 post-transplant and on worsening graft function...
October 24, 2017: World Journal of Transplantation
https://www.readbyqxmd.com/read/29099505/histological-findings-and-lung-dust-analysis-as-the-basis-for-occupational-disease-compensation-in-asbestos-related-lung-cancer-in-germany
#4
Inke Sabine Feder, Anja Theile, Andrea Tannapfel
OBJECTIVES: This study has researched the significance of histologically raised findings and lung dust analyses in the context of claiming the recognition of and thus compensation for an asbestos-associated occupational disease. MATERIAL AND METHODS: For this approach, all findings from the German Mesothelioma Register in 2015 that included lung dust analyses were evaluated and were compared with information on asbestos fiber exposure at work based on fiber years, and with the results of radiological findings...
November 2, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/29064575/dna-detection-of-jc-and-bk-virus-in-archival-urine-cytospin-slides
#5
Patricia Gioia de Assis, Carlos Eduardo de Souza Carvalho, Marcelo Soares da Mota E Silva, Maria da Gloria da Costa Carvalho
INTRODUCTION: To identify decoy cells, cytological examination was performed in urine cytospin slides. Decoy cells are related to Polyomaviruses (JC virus [JCV] and BK virus [BKV]), which are recognized worldwide due to potential infection and morbidity in kidney transplantrecipients. Cytologically, it is difficult to evaluate the cytopathic effect of JC and BK virus in urine of patients with urothelial neoplasia. For this reason, there is a need for molecular approaches. OBJECTIVE: To evaluate the incidence of BKV and JCV DNA in archival slides of urine cytospin material with benign and malignant characteristics...
October 24, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29064181/a-mayo-clinic-13-year-investigation-of-the-syndrome-of-rapid-onset-esrd-among-renal-transplant-recipients-an-analysis-of-the-implications-of-renal-allograft-biopsy-results
#6
REVIEW
Macaulay Amechi Onuigbo, Nneoma Agbasi
INTRODUCTION: We first described the syndrome of rapid onset end stage renal disease (SORO-ESRD), acute yet irreversible renal failure, in 2010. OBJECTIVE: The impact of SORO-ESRD renal allograft survival remains speculative and we plan to study this question. METHODS: A retrospective analysis of individual adult patient-level serum creatinine trajectories of ESRD patients on maintenance hemodialysis for >90 days at Mayo Clinic, Rochester, 2001-2013...
October 2017: Hemodialysis International
https://www.readbyqxmd.com/read/29042457/neutralizing-antibody-mediated-response-and-risk-of-bk-virus-associated-nephropathy
#7
Morgane Solis, Aurélie Velay, Raphaël Porcher, Pilar Domingo-Calap, Eric Soulier, Mélanie Joly, Mariam Meddeb, Wallys Kack-Kack, Bruno Moulin, Siamak Bahram, Françoise Stoll-Keller, Heidi Barth, Sophie Caillard, Samira Fafi-Kremer
BK virus-associated nephropathy (BKVAN) causes renal allograft dysfunction. The current management of BKVAN relies on pre-emptive adaptation of immunosuppression according to viral load monitoring. However, this empiric strategy is not always successful. Therefore, pretransplant predictive markers are needed. In a prospective longitudinal study, we enrolled 168 kidney transplant recipients and 69 matched donors. To assess the value of BKV genotype-specific neutralizing antibody (NAb) titers as a predictive marker for BKV replication, we measured BKV DNA load and NAb titers at transplant and followed patients for 24 months...
October 17, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29032062/virus-specific-t-cells-broadening-applicability
#8
REVIEW
A John Barrett, Susan Prockop, Catherine M Bollard
Virus infection remains an appreciable cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). Although pharmacotherapy and/or antibody therapy may help prevent or treat viral disease, these drugs are expensive, toxic, and often ineffective due to primary or secondary resistance. Further, effective treatments are limited for many infections (eg, adenovirus, BK virus), which are increasingly detected after alternative donor transplants. These deficiencies in conventional therapeutics have increased interest in an immunotherapeutic approach to viral disorders, leading to adoptive transfer of virus-specific cytotoxic T lymphocytes (VSTs), which can rapidly reconstitute antiviral immunity post-transplantation without causing graft-versus-host disease...
October 12, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29020348/kinetics-of-double-stranded-dna-viremia-after-allogeneic-hematopoietic-cell-transplantation
#9
Joshua A Hill, Bryan T Mayer, Hu Xie, Wendy M Leisenring, Meei-Li Huang, Terry Stevens-Ayers, Filippo Milano, Colleen Delaney, Keith R Jerome, Danielle M Zerr, Garrett Nichols, Michael Boeckh, Joshua T Schiffer
Background: Improved understanding of double stranded DNA (dsDNA) virus kinetics after hematopoietic cell transplantation (HCT) would facilitate development of therapeutic strategies. Methods: We tested weekly plasma samples from 404 patients through day 100 after allogeneic HCT for cytomegalovirus (CMV), human herpesvirus 6B (HHV-6B), HHV-6A, BK polyomavirus (BKV), adenovirus (AdV), and Epstein-Barr virus (EBV) using quantitative PCR. Episodes lasting ≤1 week were defined as blips and >1 week as persistent...
September 9, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28980390/treatment-for-presumed-bk-polyomavirus-nephropathy-and-risk-of-urinary-tract-cancers-among-kidney-transplant-recipients-in-the-united-states
#10
Gaurav Gupta, Sarat Kuppachi, Roberto S Kalil, Christopher B Buck, Charles F Lynch, Eric A Engels
Recent case series describe detection of BK polyomavirus (BKV) in urinary tract cancers in kidney transplant recipients, suggesting that BKV could contribute to the development of these cancers. We assessed risk for urinary tract cancers in kidney recipients with or without treatment for presumed BKV nephropathy (tBKVN) using data from the United States Transplant Cancer Match Study (2003-2013). Among 55 697 included recipients, 2015 (3.6%) were reported with tBKVN. Relative to the general population, incidence was similarly elevated (approximately 4...
October 5, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28954487/occurrence-of-bk-virus-and-human-papilloma-virus-in-colorectal-cancer
#11
Adrian Jarzyński, Przemysław Zając, Remigiusz Żebrowski, Anastazja Boguszewska, Małgorzata Polz-Dacewicz
INTRODUCTION AND OBJECTIVE: Colorectal cancer is one of the most common cancers worldwide. In Poland, it is the second most common cancer, regardless of gender. The aim of study was to analyze the incidence of HPV and BKV in the tissue of colorectal cancer and to determine the relationship between the presence of these viruses and the development of this cancer. MATERIAL AND METHODS: The experiments were conducted using 50 colorectal cancer tissues collected from histological sections...
September 21, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28942429/increased-incidence-of-bk-virus-viraemia-among-patients-undergoing-chronic-haemodialysis-a-case-control-study
#12
Samer Fuad Swedan
AIMS: Incidence of BK virus (BKV) viraemia, a major risk factor for nephropathy, among patients undergoing chronic haemodialysis remains poorly investigated. This case-control study evaluated the risk of infection by BKV, in addition to hepatitis C virus (HCV) among haemodialysis subjects (n=100), compared with age-matched controls (n=100). METHODS: Subjects' blood plasma samples were subjected to nucleic acid extraction, followed by real-time PCR to evaluate viraemia by BKV and HCV, while sera samples were subjected to ELISA, to identify IgG seropositivity for HCV...
September 23, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28927823/t-cell-therapies-for-human-polyomavirus-diseases
#13
REVIEW
Sarah I Davies, Pawel Muranski
Rapid restoration of virus-specific T immunity via adoptive transfer of ex vivo generated T cells has been proven as a powerful therapy for patients with advanced cancers and refractory viral infections such as cytomegalovirus (CMV) and Epstein-Barr virus (EBV). BK virus (BKV), John Cunningham virus (JCV), and Merkel cell carcinoma virus (MCV) are the members of the rapidly growing human polyomavirus (hPyV) family that commonly infects most healthy humans. These viruses have a clearly established potential for causing severe end-organ damage or malignant transformation, especially in individuals with weakened immunity who are unable to mount or regain endogenous T-cell responses as a result of underlying leukemia or iatrogenic immunosuppression in autoimmunity, bone marrow and solid organ transplant settings...
September 15, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28923623/mycophenolate-mofetil-withdrawal-with-conversion-to-everolimus-to-treat-bk-virus-infection-in-kidney-transplant-recipients
#14
D Wojciechowski, S Chandran, A Webber, R Hirose, F Vincenti
BACKGROUND: BK virus (BKV) is a significant post-transplant infection. Mammalian target of rapamycin inhibitors (mTORis) reduce BKV large T antigen expression in vitro and are associated with lower rates of BKV infection when used as de novo immunosuppression in clinical studies. METHODS: We performed a prospective, single-center, randomized, open label pilot trial to evaluate the impact of mycophenolate mofetil (MMF) withdrawal with conversion to the mTORi everolimus versus a 50% reduction of the MMF dose for the treatment of BKV infection after kidney transplantation...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28902772/urinary-cxcl10-chemokine-is-associated-with-alloimmune-and-virus-compartment-specific-renal-allograft-inflammation
#15
Julie Ho, Stefan Schaub, Chris Wiebe, Ang Gao, Caroline Wehmeier, Michael T Koller, Hans H Hirsch, Helmut Hopfer, Peter Nickerson, Patricia Hirt-Minkowski
BACKGROUND: Urinary CXCL10 is a promising biomarker for subclinical tubulointerstitial inflammation, but limited data exists regarding its correlation with (micro)vascular inflammation. Furthermore, no study has evaluated whether concomitant serum CXCL10 improves the discrimination for (micro)vascular inflammation. METHODS: We investigated whether serum/urinary CXCL10 reflect subclinical inflammation within different renal compartments. Patients (n=107) with 107 surveillance biopsies were classified as: normal histology (n=47), normal histology with BKV or CMV viremia (n=17), moderate-severe tubulointerstitial inflammation (tubulitis ≥2, n=18), pure microvascular inflammation (n=15), and isolated v lesions (n=10)...
September 12, 2017: Transplantation
https://www.readbyqxmd.com/read/28867309/b-cell-activating-factor-baff-reflects-patients-immunological-risk-profile-after-kidney-transplantation
#16
A Schuster, B Jung, J Hofbauer, L Kühne, D Zecher, B Banas, T Bergler
The B-cell activating factor BAFF plays an important role in the development and maturation of B-lymphocytes, which can contribute to the generation of donor-specific antibodies and thus may influence graft function and graft survival. Inconsistent data on the role of BAFF levels after renal transplantation for the formation of donor-specific antibodies and the contribution for allograft rejection exist. The aim of the current study was to determine to what extent the degree of pre-immunization is reflected by each patient's BAFF levels before transplantation and in the follow-up...
September 1, 2017: Transplant Immunology
https://www.readbyqxmd.com/read/28801294/-early-intervention-of-bk-virus-replication-promotes-stabilization-of-renal-graft-function
#17
Wei-Ming Deng, Yan-Na Liu, Li-Xin Yu, Wen-Feng Deng, Shao-Jie Fu, Jian Xu, Chuan-Fu DU, Yi-Bin Wang, Ru-Min Liu, Gui-Rong Ye, Gang Huang, Yun Miao
OBJECTIVE: To investigate the optimal time window for intervention of BK virus (BKV) replication and its effect on the outcomes of kidney transplant recipients (KTRs). METHODS: A retrospective analysis of the clinical data and treatment regimens was conducted among KTRs whose urine BKV load was ≥1.0×10(4) copies/mL following the operation between April, 2000 and April, 2015. KTRs with urine BKV load <1.0×10(4) copies/mL matched for transplantation time served as the control group...
August 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28783452/off-the-shelf-virus-specific-t-cells-to-treat-bk-virus-human-herpesvirus-6-cytomegalovirus-epstein-barr-virus-and-adenovirus-infections-after-allogeneic-hematopoietic-stem-cell-transplantation
#18
Ifigeneia Tzannou, Anastasia Papadopoulou, Swati Naik, Kathryn Leung, Caridad A Martinez, Carlos A Ramos, George Carrum, Ghadir Sasa, Premal Lulla, Ayumi Watanabe, Manik Kuvalekar, Adrian P Gee, Meng-Fen Wu, Hao Liu, Bambi J Grilley, Robert A Krance, Stephen Gottschalk, Malcolm K Brenner, Cliona M Rooney, Helen E Heslop, Ann M Leen, Bilal Omer
Purpose Improvement of cure rates for patients treated with allogeneic hematopoietic stem-cell transplantation (HSCT) will require efforts to decrease treatment-related mortality from severe viral infections. Adoptively transferred virus-specific T cells (VSTs) generated from eligible, third-party donors could provide broad antiviral protection to recipients of HSCT as an immediately available off-the-shelf product. Patient and Methods We generated a bank of VSTs that recognized five common viral pathogens: Epstein-Barr virus (EBV), adenovirus (AdV), cytomegalovirus (CMV), BK virus (BKV), and human herpesvirus 6 (HHV-6)...
November 1, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28751760/il28b-rs12979860-genotype-as-a-predictor-marker-of-progression-to-bkvirus-associated-nephropathy-after-kidney-transplantation
#19
Roee Dvir, Vera Paloschi, Filippo Canducci, Giacomo Dell'Antonio, Sara Racca, Rossana Caldara, Giuseppe Pantaleo, Massimo Clementi, Antonio Secchi
BK virus (BKV) associated nephropathy (BKVAN) is still an important cause of allograft dysfunction after kidney transplantation (KT). Recent data have shown that the new interferon (IFN)-λ family has been ascribed antiviral properties similar to IFNα, and that the response to IFNλ in kidney is restricted to epithelial cells, suggesting that the IFNλ system evolves as specific protection of the epithelia. We aimed to test the hypothesis of correlation between a single nucleotide polymorphism (C/T dimorphism rs12979860) in the genomic region of IL28B and BKVAN, in patients after KT...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28735997/feasibility-of-bk-virus-real-time-pcr-testing-in-renal-graft-biopsies-with-negative-sv40-staining
#20
R Morace, T Kumar, E Tantisattamo, J Gibson, S Britton, W Li, H D Kanaan, S R Cohn, D Samarapungavan, P L Zhang, B L Boyanton
BACKGROUND: BK virus (BKV)-associated nephropathy (BKVAN) is often associated with renal graft dysfunction. When renal transplant recipients present with high clinical suspicion for BKVAN (high serum and urine BKV titer with graft dysfunction) but their graft biopsies stain negatively for BKV, non-correlated situations between the two tests often lead to a dilemma about how to treat them. METHODS: This retrospective investigation was conducted to determine how real-time quantitative PCR (qPCR) for BKV, routinely applied to serum and urine, could be helpful in identifying the existing BKV in biopsy tissue stained negatively for BKV...
July 2017: Transplantation Proceedings
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