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https://www.readbyqxmd.com/read/28812237/pharmacological-effects-on-ceroid-lipofuscin-and-neuronal-structure-in-cln3-%C3%A2-ex7-8-mouse-brain-cultures
#1
Douglas E Brenneman, David A Pearce, Attila Kovacs, Shawn DeFrees
Juvenile Batten disease (JBD) is an inherited disorder that is characterized by the development of blindness, seizures, and progressive motor, psychiatric, and cognitive impairment. A model of JBD expressing the predominant human mutation (Cln3 (∆ex7/8) ) has been explored. Dissociated brain cultures from Cln3 (∆ex7/8) knock-in mice were compared to wild type (WT) for effects on granules of ceroid lipofuscin (CL) and neuronal structure. Utilizing high content image analysis of CL granules identified with antibodies to mitochondrial ATP synthase subunit c or tripeptidyl peptidase-1, significant increases in the areas for both immunoreactive granules were observed in Cln3 (∆ex7/8) cultures in comparison to WT...
August 15, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28808856/validation-of-veterans-affairs-electronic-medical-record-smoking-data-among-iraq-and-afghanistan-era-veterans
#2
Patrick S Calhoun, Sarah M Wilson, Jeffrey S Hertzberg, Angela C Kirby, Scott D McDonald, Paul A Dennis, Lori A Bastian, Eric A Dedert, Jean C Beckham
BACKGROUND: Research using the Veterans Health Administration (VA) electronic medical records (EMR) has been limited by a lack of reliable smoking data. OBJECTIVE: To evaluate the validity of using VA EMR "Health Factors" data to determine smoking status among veterans with recent military service. DESIGN: Sensitivity, specificity, area under the receiver-operating curve (AUC), and kappa statistics were used to evaluate concordance between VA EMR smoking status and criterion smoking status...
August 14, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28807139/recognition-of-anxiety-depression-and-ptsd-in-patients-with-copd-and-chf-who-gets-missed
#3
Chelsea G Ratcliff, Terri L Barrera, Nancy J Petersen, Shubhada Sansgiry, Michael R Kauth, Mark E Kunik, Melinda A Stanley, Jeffrey A Cully
OBJECTIVE: This study sought to identify patient factors associated with mental health (MH) recognition and treatment in medically ill Veterans. METHOD: Retrospective data from patient electronic medical records (EMR) and self-report data were reviewed for 180 Veterans with cardiopulmonary conditions who met diagnostic criteria for anxiety, depression, or posttraumatic stress disorder on the Mini-International Neuropsychiatric Interview. Multivariate logistic regression examined the association of medical record MH recognition and MH service use with patient factors, including anxiety and depression severity, self-efficacy, locus of control, coping, illness intrusiveness, and health-related quality of life (QOL)...
July 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28807136/misuse-of-prescription-opioids-among-chronic-pain-patients-suffering-from-anxiety-a-cross-sectional-analysis
#4
Daniel Feingold, Silviu Brill, Itay Goor-Aryeh, Yael Delayahu, Shaul Lev-Ran
OBJECTIVE: In the past two decades, chronic pain has been increasingly treated with prescription opioids, particularly in developed countries. This has drawn public concern of possible risks associated with the potential misuse of prescriptions opioids. Previous research has indicated that this may be particularly true among individuals suffering from co-occurring psychiatric disorders. The present study sought to explore rates of misuse among chronic pain patients prescribed opioids, comparing individuals with and without anxiety...
July 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28807133/the-tense-the-hostile-and-the-distressed-multidimensional-psychosocial-risk-profiles-based-on-the-esc-interview-in-coronary-artery-disease-patients-the-thoresci-study
#5
Eveline van Montfort, Johan Denollet, Jeroen K Vermunt, Jos Widdershoven, Nina Kupper
BACKGROUND: While single psychosocial factors have been associated with cardiovascular outcomes, it is still unclear how they cluster. Therefore, we examined whether latent multidimensional psychosocial risk profiles could be identified in the European Society of Cardiology (ESC) psychosocial screening interview. Additionally we examined whether these profiles were associated with specific sociodemographic, clinical, and psychosocial characteristics. METHOD: 681 coronary artery disease patients (age=64...
July 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28807009/adverse-mental-health-outcomes-in-breast-cancer-survivors-compared-to-women-who-did-not-have-cancer-systematic-review-protocol
#6
Helena Carreira, Rachael Williams, Martin Müller, Rhea Harewood, Krishnan Bhaskaran
BACKGROUND: Recent increasing trends in breast cancer incidence and survival have resulted in unprecedented numbers of cancer survivors in the general population. A cancer diagnosis may have a profound psychological impact, and breast cancer treatments often cause long-term physical sequelae, potentially affecting women's mental health. The aim of this systematic review is to identify and summarise all studies that have compared mental health outcomes in breast cancer survivors, versus women who did not have cancer...
August 14, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28801755/a-cross-national-comparison-of-violence-among-young-men-in-china-and-the-uk-psychiatric-and-cultural-explanations
#7
Jeremy Coid, Junmei Hu, Constantinos Kallis, Yuan Ping, Juying Zhang, Yueying Hu, Laura Bui, Simone Ullrich, Paul Bebbington
PURPOSE: Public health psychiatry has a key role in violence prevention. Cross-national comparisons of violence and associated psychiatric morbidity can indicate targets for preventive interventions. METHOD: Data on young adult men in households, 18-34 years, were drawn from the Second Men's Modern Lifestyles survey in Great Britain (n = 2046) and from a corresponding survey in Chengdu, China (n = 4132), using a translated questionnaire. Binary logistic regression models were carried out to estimate the cross-national differences for different types of violence and to identify explanatory variables...
August 11, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28797561/self-reported-psychosis-like-experiences-in-patients-with-mood-disorders
#8
I Baryshnikov, J Suvisaari, K Aaltonen, M Koivisto, T Melartin, P Näätänen, K Suominen, B Karpov, M Heikkinen, J Oksanen, T Paunio, G Joffe, E Isometsä
BACKGROUND: Self-reported psychosis-like experiences (PEs) may be common in patients with mood disorders, but their clinical correlates are not well known. We investigated their prevalence and relationships with self-reported symptoms of depression, mania, anxiety, borderline (BPD) and schizotypal (SPD) personality disorders among psychiatric patients with mood disorders. METHODS: The Community Assessment of Psychic Experiences (CAPE-42), Mood Disorder Questionnaire (MDQ), McLean Screening Instrument (MSI), The Beck Depressive Inventory (BDI), Overall Anxiety Severity and Impairment Scale (OASIS) and Schizotypal Personality Questionnaire-Brief form (SPQ-B) were filled in by patients with mood disorders (n=282) from specialized care...
February 3, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28797526/psychotic-experiences-and-disability-findings-from-the-collaborative-psychiatric-epidemiology-surveys
#9
Hans Oh, Ai Koyanagi, Ian Kelleher, Jordan DeVylder
Psychotic experiences are associated with a number of poor clinical outcomes, including multimorbid psychopathology, suicidal behavior, and poor treatment response. We wished to investigate the relationship between psychotic experiences and disability, including the following domains: cognition, mobility, self-care, social interaction, role functioning, and days out of role. We used three nationally representative and racially/ethnically diverse samples of the general US adult population: the National Comorbidity Survey Replication (NCS-R), the National Latino and Asian American Survey (NLAAS), and the National Survey of American Life (NSAL)...
August 7, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28797371/dementia-for-the-primary-care-provider
#10
REVIEW
Daniela Claudia Moga, Monica Roberts, Gregory Jicha
Dementia represents one of the most important and growing public health issues facing society today. Primary care clinics serve a crucial role as the first line of defense in the recognition and treatment of dementia. Increased awareness and treatment of risk factors for dementia are important for lessening disease burden in the population. Diagnostic workup should include screening for medical and nondegenerative causes of cognitive impairment that may be remedial. Treatment approaches should include multimodal approaches to address cognitive decline and behavioral/psychiatric symptoms of dementia in an effort to maximize quality of life for both patients and caregivers...
September 2017: Primary Care
https://www.readbyqxmd.com/read/28796120/synthetic-cannabis-analogues-and-suicidal-behavior-case-report
#11
Pedro Miguel Dos Santos Oliveira, Ana Sofia Félix Morais, Nuno Gonçalo Gomes Fernandes Madeira
INTRODUCTION: Despite growing legal control, a wide range of synthetic cannabis analogues is currently used for recreational purposes, notwithstanding their well adverse outcomes, which appear to be more frequent and more serious than those associated with cannabis use. We present the case report of a patient with paranoid schizophrenia, who attempted suicide by serious bodily harm after a single use of "Shiva Ultra Strong," a compound of several synthetic cannabis analogues. CASE SUMMARY: A 32-year-old male patient with paranoid schizophrenia was brought to the emergency department presenting with a severe self-inflicted wound to the neck which lacerated the right jugular vein and ipsilateral airway, and narrowly missed the carotid bifurcation...
August 8, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28795636/athletic-identity-and-psychiatric-symptoms-following-retirement-from-varsity-sports
#12
Zarina A Giannone, Colleen J Haney, David Kealy, John S Ogrodniczuk
BACKGROUND: Despite evidence identifying adjustment difficulties among retiring athletes, research investigating factors that contribute to post-retirement complications is limited. Athletic identity may be an important determinant of adverse adaptation to sport retirement. AIMS: The purpose of this study was to address the influence of athletic identity on post-retirement depression and anxiety symptoms among varsity athletes. METHOD: An anonymous, online survey regarding athletic identity and psychiatric symptoms was completed by 72 self-identified varsity athletes during their final season of competition and 3 months after retiring from sport...
August 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28792097/a-closer-lens-cancer-survivors-supportive-intervention-preferences-and-interventions-received
#13
Joanna J Arch, Rachel Vanderkruik, Alex Kirk, Alaina L Carr
BACKGROUND: Cancer survivor preferences for formal interventions designed to provide psychological support remain relatively unknown. To address this gap, we evaluated cancer survivors' preferences for psychological intervention, whom they preferred to recommend such intervention, and how their preferences compared with what they currently received. METHODS: U.S. cancer survivors (n = 345) who were at least 2 months post-treatment for diverse forms of cancer were recruited online to complete a survey study...
August 9, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28791709/risk-of-being-convicted-of-theft-and-other-crimes-in-anorexia-and-bulimia-nervosa-a-prospective-cohort-study-in-a-swedish-female-population
#14
Shuyang Yao, Ralf Kuja-Halkola, Laura M Thornton, Claes Norring, Catarina Almqvist, Brian M D'Onofrio, Paul Lichtenstein, Niklas Långström, Cynthia M Bulik, Henrik Larsson
OBJECTIVE: We examined epidemiological associations between anorexia nervosa (AN) and bulimia nervosa (BN) and risks of committing theft and other crimes in a nationwide female population. METHOD: Females born in Sweden during 1979-1998 (N = 957,106) were followed from age 15 for up to 20 years using information on clinically diagnosed AN and BN (exposures), convictions of theft and other crimes (outcomes), psychiatric comorbidities, and familial relatedness from Swedish national registers...
August 9, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28789981/tobacco-and-nicotine-delivery-product-use-in-a-national-sample-of-pregnant-women
#15
Allison N Kurti, Ryan Redner, Alexa A Lopez, Diana R Keith, Andrea C Villanti, Cassandra A Stanton, Diann E Gaalema, Janice Y Bunn, Nathan J Doogan, Antonio Cepeda-Benito, Megan E Roberts, Julie Phillips, Stephen T Higgins
Monitoring use of tobacco products among pregnant women is a public health priority, yet few studies in U.S. national samples have been reported on this topic. We examined prevalence and correlates of using cigarettes, e-cigarettes, and other tobacco/nicotine delivery products in a U.S. national sample of pregnant women. Data were obtained from all pregnant women (≥18 years) in the first wave of the Population Assessment of Tobacco and Health (PATH, 2013-2014) Study (N=388). Prevalence of current and prior use of tobacco/nicotine products was examined overall and among current cigarette smokers...
August 5, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28783935/the-relationship-between-ghrelin-and-copeptin-levels-and-anxiety-and-depression-levels-in-suicide-attempts
#16
Metin Atescelik, Mustafa Yilmaz, Sevda Korkmaz, Mehmet Cagri Goktekin, Mehtap Gurger, Nevin Ilhan
Objective: It was aimed to detect acylated ghrelin (AG), unacylated ghrelin (UG) and copeptin levels in patients with suicide attempts and to determine if these biomarkers are risk factors for suicide attempts. Methods: Serum copeptin, AG and GU levels were screened in 128 patients who were admitted to emergency department with suicide attempts and 59 healthy controls. Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) were applied simultaneously, and the data were compared statistically...
August 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28783739/prevalence-and-factors-associated-with-depression-in-people-living-with-hiv-in-sub-saharan-africa-a-systematic-review-and-meta-analysis
#17
Charlotte Bernard, François Dabis, Nathalie de Rekeneire
Depression, one of the most common psychiatric disorders, is two- to three-times more prevalent in people living with HIV (PLHIV) than in the general population in many settings as shown in western countries but remains neglected in sub-Saharan Africa (SSA). We aimed to summarize the available evidence on the prevalence of depression and associated factors according to the scales used and the treatment status in PLHIV in SSA. The pooled prevalence estimates of depression ranged between 9% and 32% in PLHIV on antiretroviral treatment (ART) and in untreated or mixed (treated/untreated) ones, with a substantial variability according to the measurement scale used and also for a given scale...
2017: PloS One
https://www.readbyqxmd.com/read/28783090/validation-study-of-italian-version-of-inventory-for-d%C3%A3-j%C3%A3-vu-experiences-assessment-i-idea-a-screening-tool-to-detect-d%C3%A3-j%C3%A3-vu-phenomenon-in-italian-healthy-individuals
#18
Laura Mumoli, Giovanni Tripepi, Umberto Aguglia, Antonio Augimeri, Rossella Baggetta, Francesca Bisulli, Antonella Bruni, Salvatore M Cavalli, Alfredo D'Aniello, Ornella Daniele, Carlo Di Bonaventura, Giancarlo Di Gennaro, Jinane Fattouch, Edoardo Ferlazzo, Alessandra Ferrari, Annateresa Giallonardo, Sara Gasparini, Salvatore Nigro, Andrea Romigi, Vito Sofia, Paolo Tinuper, Maria Grazia Vaccaro, Leila Zummo, Aldo Quattrone, Antonio Gambardella, Angelo Labate
The Inventory Déjà Vu Experiences Assessment (IDEA) is the only screening instrument proposed to evaluate the Déjà vu (DV) experience. Here, we intended to validate the Italian version of IDEA (I-IDEA) and at the same time to investigate the incidence and subjective qualities of the DV phenomenon in healthy Italian adult individuals on basis of an Italian multicentre observational study. In this study, we report normative data on the I-IDEA, collected on a sample of 542 Italian healthy subjects aging between 18-70 years (average age: 40) with a formal educational from 1-19 years...
August 7, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28782982/sleep-continuity-architecture-and-quality-among-treatment-seeking-cannabis-users-an-in-home-unattended-polysomnographic-study
#19
Lauren R Pacek, Evan S Herrmann, Michael T Smith, Ryan Vandrey
The objective of the study was to describe self-report and objectively measured sleep characteristics of adult treatment-seeking cannabis users. Study participants (n = 87) were adults who were screened for a 12-week outpatient cannabis treatment research program in Baltimore, MD. Participants completed objective and self-report measures of sleep quality. Data were analyzed for the sample overall and after stratifying by sex (54 men, 33 women). Participants were primarily urban, socioeconomically disadvantaged African Americans...
August 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28777732/body-image-and-eating-disorders-are-common-among-professional-and-amateur-athletes-using-performance-and-image-enhancing-drugs-a-cross-sectional-study
#20
Daria Piacentino, Georgios D Kotzalidis, Livia Longo, Antonio Pavan, Luciano Stivali, Guido Stivali, Stefano Ferracuti, Roberto Brugnoli, Paola Frati, Vittorio Fineschi, Paolo Girardi, Gabriele Sani
The use of performance and image enhancing drugs (PIEDs) is not uncommon in athletes and appears to be associated with several psychopathological disorders of unclear prevalence. In this multicenter, cross-sectional study, we aimed to evaluate the prevalence of body image disorders (BIDs) and eating disorders (EDs) in PIED-using athletes vs. PIED nonusers. We enrolled 84 consecutive professional and amateur athletes training in sport centers in Italy, who underwent semi-structured interviews (SCID-I, SCID-II) and completed the Body Image Concern Inventory (BICI) and the Sick, Control, One, Fat, Food Eating Disorder Screening Test (SCOFF)...
August 4, 2017: Journal of Psychoactive Drugs
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