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diagnosis hepatic steatosis

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https://www.readbyqxmd.com/read/27908400/low-hepatic-copper-content-and-pnpla3-polymorphism-in-non-alcoholic-fatty-liver-disease-in-patients-without-metabolic-syndrome
#1
Albert Friedrich Stättermayer, Stefan Traussnigg, Elmar Aigner, Christian Kienbacher, Ursula Huber-Schönauer, Petra Steindl-Munda, Andreas Stadlmayr, Friedrich Wrba, Michael Trauner, Christian Datz, Peter Ferenci
INTRODUCTION: The pathogenesis of non-alcoholic fatty liver disease (NAFLD) is multifactorial including metabolic, genetic (e.g. PNPLA3 [patatin-like phospholipase domain-containing 3 gene]), viral factors and drugs. Besides, there is evidence for a role of copper deficiency. Aim of the study was to evaluate the role of hepatic copper content, PNPLA3 in NAFLD patients with and without metabolic syndrome (MetS). METHODS: One-hundred seventy-four NAFLD patients, who underwent liver biopsy for diagnostic work-up, were studied...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27898581/kinetics-of-plasma-triglycerides-in-abdominal-obesity
#2
Elias Björnson, Martin Adiels, Marja-Riitta Taskinen, Jan Borén
PURPOSE OF REVIEW: Abdominal obesity is associated with a number of important metabolic abnormalities including liver steatosis, insulin resistance and an atherogenic lipoprotein profile (termed dyslipidemia). The purpose of this review is to highlight recent progress in understanding the pathogenesis of this dyslipidemia. RECENT FINDINGS: Recent results from kinetic studies using stable isotopes indicate that the hypertriglyceridemia associated with abdominal obesity stems from dual mechanisms: (1) enhanced secretion of triglyceride-rich lipoproteins and (2) impaired clearance of these lipoproteins...
November 24, 2016: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/27872651/a-review-of-western-and-traditional-chinese-medical-approaches-to-managing-nonalcoholic-fatty-liver-disease
#3
REVIEW
Wei-Fan Hsu, Lee-Yan Sheen, Hung-Jen Lin, Hen-Hong Chang
Nonalcoholic fatty liver disease (NAFLD) is a disease of attention because of increase in prevalence from 20% to 41%. The clinical and pathological conditions in patients with NAFLD range from steatosis alone to nonalcoholic steatohepatitis (NASH) with or without fibrosis to hepatic cancer. In the United States, NAFLD was the second-leading indication for liver transplant between 2004 and 2013. Although imaging studies such as magnetic resonance elastography and the use of diagnostic panels and scoring systems can provide a fairly accurate diagnosis of NAFLD, there are few treatment options for patients with mild to moderate disease other than lifestyle modification...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27866088/is-ketogenic-diet-treatment-hepatotoxic-for-children-with-intractable-epilepsy
#4
Nur Arslan, Orkide Guzel, Engin Kose, Unsal Yılmaz, Pınar Kuyum, Betül Aksoy, Tansel Çalık
PURPOSE: Long-term ketogenic diet (KD) treatment has been shown to induce liver steatosis and gallstone formation in some in vivo and clinical studies. The aim of this retrospective study was to evaluate the hepatic side effects of KD in epileptic children. METHOD: A total of 141 patients (mean age: 7.1±4.1years [2-18 years], 45.4% girls), receiving KD at least one year for intractable epilepsy due to different diagnoses (congenital brain defects, GLUT-1 deficiency, West syndrome, tuberous sclerosis, hypoxic brain injury, etc...
November 13, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27822268/noninvasive-diagnosis-of-hepatic-steatosis-using-fat-attenuation-parameter-measured-by-fibrotouch-and-a-new-algorithm-in-chb-patients
#5
Hong Deng, Chun-Ling Wang, Jing Lai, Su-Lin Yu, Dong-Ying Xie, Zhi-Liang Gao
BACKGROUND: Chronic hepatitis B (CHB) remains a major public health problem worldwide, and the prevalence of CHB patients with hepatic steatosis is gradually increasing. Noninvasive approaches for the assessment of hepatic steatosis have been developed as alternatives to liver biopsy. OBJECTIVES: This study evaluated the diagnostic performance of the fat attenuation parameter (FAP) measured by transient elastography (FibroTouch) and a new algorithm to assess hepatic steatosis in CHB patients, in comparison to liver biopsy as the gold standard...
September 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27816954/metabolite-profiling-can-change-health-care-delivery-to-obese-patients-with-fatty-liver-disease-the-search-for-biomarkers
#6
Jordi Camps, Jorge Joven
Comorbidities associated with obesity have become a worldwide public health concern. Obesity-associated hepatic steatosis is not benign, and the risk of developing severe liver disease is high. Currently, biopsy is the only clinical tool available for the diagnosis of pathological alterations in the liver. However, the procedure is painful and not without risk. As such, there is a need to identify non-invasive biomarkers of steatosis. There has been considerable progress in this area, but research appears to be limited to measurements of levels of certain parameters in patients with liver impairment relative to those of healthy controls...
November 7, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27792191/tomato-juice-consumption-modifies-the-urinary-peptide-profile-in-sprague-dawley-rats-with-induced-hepatic-steatosis
#7
Gala Martín-Pozuelo, Rocío González-Barrio, Gonzalo G Barberá, Amaya Albalat, Javier García-Alonso, William Mullen, Harald Mischak, María Jesús Periago
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in Western countries, with a high prevalence, and has been shown to increase the risk of type 2 diabetes, cardiovascular disease (CVD), etc. Tomato products contain several natural antioxidants, including lycopene-which has displayed a preventive effect on the development of steatosis and CVD. Accordingly, the aim of the present work was to evaluate the effect of tomato juice consumption on the urinary peptide profile in rats with NAFLD induced by an atherogenic diet and to identify potential peptide biomarkers for diagnosis...
October 26, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27783208/non-invasive-diagnosis-of-hepatic-steatosis
#8
REVIEW
Christiane Stern, Laurent Castera
Non-invasive diagnosis and quantification of hepatic steatosis rely on two different but complementary approaches: biomarkers or imaging techniques, either ultrasound-based such as liver ultrasonography and controlled attenuation parameter (CAP), or computed tomography (CT) and magnetic resonance imaging (MRI). Scores for the detection of steatosis have not gained much popularity in clinical practice so far. CAP, using the M probe, is the most promising technique but needs to be implemented with the XL probe and compared to ultrasound that, despite its limitations, remains the most widely used method...
October 25, 2016: Hepatology International
https://www.readbyqxmd.com/read/27745935/-insulin-edema-in-hepatic-glycogenosis
#9
T Mahévas, D Gobert, M Gatfossé, A Mekinian, O Fain
INTRODUCTION: Hepatic glycogenosis is a rare syndrome, which includes poorly controlled diabetes mellitus, hepatomegaly, delayed puberty, and growth delay. Insulin edema is sometimes associated. CASE REPORT: An 18-year-old woman presented with diffuse edema, hepatomegaly, amenorrhea, uncontrolled diabetes, and elevated transaminases and cholestasis. Hepatic ultrasonography and abdominal computed tomographic scan confirmed the hepatomegaly. The liver biopsy showed a massive glycogenosis and the diagnosis of hepatic glycogenosis was confirmed...
October 13, 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/27730688/increased-parenchymal-damage-and-steatohepatitis-in-caucasian-non-alcoholic-fatty-liver-disease-patients-with-common-il1b-and-il6-polymorphisms
#10
J E Nelson, P Handa, B Aouizerat, L Wilson, L A Vemulakonda, M M Yeh, K V Kowdley
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a complex, multifactorial disease affected by diet, lifestyle and genetics. Proinflammatory cytokines like IL-1β and IL-6 have been shown to be elevated in non-alcoholic steatohepatitis (NASH). AIM: To investigate the relationship between IL1B and IL6 gene polymorphisms and histological features of NAFLD in the NASH CRN cohort. METHODS: A total of 604 adult (≥18 years) non-Hispanic Caucasians with biopsy-proven NAFLD were genotyped for the following SNPs: IL1B, rs16944, rs1143634; IL6, rs1800795, rs10499563...
December 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27719652/non-invasive-assessment-of-liver-injury-in-non-alcoholic-fatty-liver-disease-a-review-of-literature
#11
M Maida, F S Macaluso, F Salomone, S Petta
NAFLD (Non-Alcoholic Fatty Liver Disease) is an increasingly significant public health issue, regarded as the most relevant liver disease of the twenty-first century. Approximately 20%-30% of NAFLD subjects develop a NASH (Non-Alcoholic Steato-Hepatitis), a condition which can potentially evolve to liver cirrhosis and hepatocellular carcinoma. For these reasons a proper evaluation of liver damage is a key point for diagnosis and prognosis and liver biopsy still remains the "gold standard" procedure both for discrimination between steatosis and steatohepatitis and assessment of the degree of liver fibrosis...
October 4, 2016: Current Molecular Medicine
https://www.readbyqxmd.com/read/27699993/transient-elastography-for-the-diagnosis-of-liver-fibrosis-a-systematic-review-of-economic-evaluations
#12
Sasha van Katwyk, Doug Coyle, Curtis Cooper, Kusala Pussegoda, Chris Cameron, Becky Skidmore, Stacey Brener, David Moher, Kednapa Thavorn
BACKGROUND: Liver biopsy remains the gold standard for the diagnosis of liver fibrosis, but its use as a diagnostic tool is limited by its invasive nature and high cost. OBJECTIVE: The aim of this study was to systematically review the cost-effectiveness of transient elastography (TE) with and without controlled attenuation parameter (CAP) for the diagnosis of liver fibrosis or steatosis in patients with hepatitis B, hepatitis C, alcoholic liver disease and non-alcoholic fatty liver disease...
October 3, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27689164/ultrasound-diagnosis-of-hepatic-steatosis-as-a-surrogate-for-atherosclerosis
#13
S Guth, E Windler, U Leise, C M Bamberger
No abstract text is available yet for this article.
March 2016: Ultrasound International Open
https://www.readbyqxmd.com/read/27669236/mir33a-mir33b-and-mir122-as-possible-contributors-to-hepatic-lipid-metabolism-in-obese-women-with-nonalcoholic-fatty-liver-disease
#14
Teresa Auguet, Gemma Aragonès, Alba Berlanga, Esther Guiu-Jurado, Andreu Martí, Salomé Martínez, Fàtima Sabench, Mercé Hernández, Carmen Aguilar, Joan Josep Sirvent, Daniel Del Castillo, Cristóbal Richart
Specific miRNA expression profiles have been shown to be associated with nonalcoholic fatty liver disease (NAFLD). We examined the correlation between the circulating levels and hepatic expression of miR122 and miR33a/b*, the key lipid metabolism-related gene expression and the clinicopathological factors of obese women with NAFLD. We measured miR122 and miR33a/b* expression in liver samples from 62 morbidly obese (MO), 30 moderately obese (ModO), and eight normal-weight controls. MiR122 and miR33a/b* expression was analyzed by qRT-PCR...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27583084/non-alcoholic-fatty-liver-disease-in-a-nigerian-population-with-type-ii-diabetes-mellitus
#15
Titilola Osawaye Olusanya, Olufunmilayo Adenike Lesi, Adekunle Ayokunle Adeyomoye, Olufemi Adetola Fasanmade
INTRODUCTION: Worldwide, Non-alcoholic fatty liver disease (NAFLD) has become an important cause of chronic liver disease and cardiovascular morbidity, even more so in subjects with Type II Diabetes Mellitus (T2DM). The aim of this study was to determine the prevalence and risk factors of NAFLD in an African population with Type II Diabetes Mellitus. METHODS: We performed a case control study and evaluated anthropometric and biochemical risk factors for NAFLD in 336 subjects (T2DM and non-diabetic controls)...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27580542/usefulness-of-magnetic-resonance-imaging-for-the-diagnosis-of-hemochromatosis-with-severe-hepatic-steatosis-in-nonalcoholic-fatty-liver-disease
#16
Yuichi Nozaki, Noriko Sato, Tsuyoshi Tajima, Kanehiro Hasuo, Yasushi Kojima, Kumiko Umemoto, Saori Mishima, Shintaro Mikami, Tomohiro Nakayama, Toru Igari, Junichi Akiyama, Masatoshi Imamura, Naohiko Masaki, Mikio Yanase
The ratio of the number of patients with non-alcoholic steatohepatitis (NASH) to the total number of patients with liver dysfunction has increased in many countries around the world. Liver dysfunction is also caused by multiple blood transfusions in patients with leukemia and other hematological diseases, with liver dysfunction often accompanied by secondary hemochromatosis. This study describes a 25-year-old man with secondary hemochromatosis combined with NASH. Magnetic resonance imaging was useful for visualizing the distributions of both iron and fat in the liver of this patient in order to make a differential diagnosis and to evaluate the effect of treatment...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27563019/magnetic-resonance-elastography-and-other-magnetic-resonance-imaging-techniques-in-chronic-liver-disease-current-status-and-future-directions
#17
REVIEW
Cher Heng Tan, Sudhakar Kundapur Venkatesh
Recent advances in the noninvasive imaging of chronic liver disease have led to improvements in diagnosis, particularly with magnetic resonance imaging (MRI). A comprehensive evaluation of the liver may be performed with the quantification of the degree of hepatic steatosis, liver iron concentration, and liver fibrosis. In addition, MRI of the liver may be used to identify complications of cirrhosis, including portal hypertension, ascites, and the development of hepatocellular carcinoma. In this review article, we discuss the state of the art techniques in liver MRI, namely, magnetic resonance elastography, hepatobiliary phase MRI, and liver fat and iron quantification MRI...
September 15, 2016: Gut and Liver
https://www.readbyqxmd.com/read/27549244/diagnostic-performance-of-fibrotest-steatotest-and-actitest-in-patients-with-nafld-using-the-saf-score-as-histological-reference
#18
M Munteanu, D Tiniakos, Q Anstee, F Charlotte, G Marchesini, E Bugianesi, M Trauner, M Romero Gomez, C Oliveira, C Day, J-F Dufour, S Bellentani, Y Ngo, S Traussnig, H Perazzo, O Deckmyn, P Bedossa, V Ratziu, T Poynard
BACKGROUND: Blood tests of liver injury are less well validated in non-alcoholic fatty liver disease (NAFLD) than in patients with chronic viral hepatitis. AIMS: To improve the validation of three blood tests used in NAFLD patients, FibroTest for fibrosis staging, SteatoTest for steatosis grading and ActiTest for inflammation activity grading. METHODS: We pre-included new NAFLD patients with biopsy and blood tests from a single-centre cohort (FibroFrance) and from the multicentre FLIP consortium...
October 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27547937/how-to-diagnose-nonalcoholic-fatty-liver-disease
#19
Nimantha M W de Alwis, Quentin M Anstee, Christopher P Day
Patients with nonalcoholic fatty liver disease (NAFLD) are asymptomatic and present with either unexplained abnormal liver blood tests or a bright liver on ultrasonography. Some patients will have normal liver blood tests raising the issue of whether patients with risk factors for NAFLD (diabetes and/or metabolic syndrome [MS]) should be screened for its presence with biomarkers, such as the fatty liver index (FLI). The diagnosis of NAFLD requires the exclusion of other causes of chronic liver disease and steatosis, especially heavy alcohol consumption and viral hepatitis particularly HCV genotype 3...
2016: Digestive Diseases
https://www.readbyqxmd.com/read/27515961/laboratory-tests-for-diagnosis-of-alcoholic-liver-disease
#20
REVIEW
Valentina Peta, Djamel Elaribi, Ludovico Abenavoli
Alcohol is considered one of the most common hepatotoxin, and chronic alcoholic liver disease is affecting millions of subjects worldwide. The three most frequently manifestations of alcoholic liver disease are steatosis, acute alcoholic hepatitis and liver cirrhosis. The diagnosis of Alcoholic Liver Diseases (ALD) is made by clinical and laboratory analysis. Actually do not exist a single laboratory test able to confirm the diagnosis of ALD, but in the last years several serum markers and laboratory abnormalities have been discovered in these patients...
2016: Reviews on Recent Clinical Trials
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