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diagnosis hepatic steatosis

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https://www.readbyqxmd.com/read/29222917/diagnostic-modalities-for-non-alcoholic-fatty-liver-disease-nafld-non-alcoholic-steatohepatitis-nash-and-associated-fibrosis
#1
REVIEW
Zobair M Younossi, Rohit Loomba, Quentin M Anstee, Mary E Rinella, Elisabetta Bugianesi, Giulio Marchesini, Brent A Neuschwander-Tetri, Lawrence Serfaty, Francesco Negro, Stephen H Caldwell, Vlad Ratziu, Kathleen E Corey, Scott L Friedman, Manal F Abdelmalek, Stephen A Harrison, Arun J Sanyal, Joel E Lavine, Philippe Mathurin, Michael R Charlton, Zachary D Goodman, Naga P Chalasani, Kris V Kowdley, Jacob George, Keith Lindor
NAFLD is a spectrum comprised of isolated steatosis, NASH, advanced fibrosis, and cirrhosis. The majority of NAFLD subjects do not have NASH and don't carry a significant risk for adverse outcomes (cirrhosis and mortality). Globally, the prevalence of NAFLD is approximately 25%. In Asia, a gradient of high prevalence rates to low rates are noted from urban to rural areas. Given the prevalence of NAFLD, the clinical and economic burden of NAFLD and NASH can be substantial. With increasing recognition as an important liver disease, the diagnosis of NASH still requires a liver biopsy which is suboptimal...
December 9, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29218616/noninvasive-assessment-of-hepatic-sinusoidal-obstructive-syndrome-using-acoustic-radiation-force-impulse-elastography-imaging-a-proof-of-concept-study-in-rat-models
#2
So Hyun Park, Seung Soo Lee, Ji-Youn Sung, Kiyong Na, Hyoung Jung Kim, So Yeon Kim, Beom Jin Park, Jae Ho Byun
OBJECTIVES: To determine the feasibility of acoustic radiation force impulse (ARFI) elastography in the evaluation of hepatic sinusoidal obstruction syndrome (SOS) in rat models. METHODS: Rat SOS models of various severities were created by monocrotaline gavage (n = 40) or by intraperitoneal injection of 5-fluorouracil, leucovorin and oxaliplatin (FOLFOX) (n = 16). Liver shear-wave velocity (SWV) was measured using ARFI elastography. Liver samples were analysed for the SOS score, steatosis, lobular inflammation and fibrosis...
December 7, 2017: European Radiology
https://www.readbyqxmd.com/read/29202675/acute-hepatic-steatosis-a-helpful-diagnostic-feature-in-metallic-phosphide-poisoned-horses
#3
Jonathan H Fox, Brian F Porter, Leslie Easterwood, Justin R V Hildenbrand, Pierre Hélie, James Smylie, Donal O'Toole
Metal phosphides, particularly zinc and aluminum phosphide, occasionally poison horses and other equids following their use as rodenticides and insecticides. Grain-based aluminum phosphide baits are used to control rodents such as prairie dogs. The clinical course in intoxicated horses is short (<24-48 h), and animals may be found dead. Hepatic lesions caused by phosphine poisoning are not well described. Laboratory confirmation depends on detecting phosphine gas in gastric contents. Eight horses and a mule were exposed to zinc phosphide used to control prairie dogs on a Wyoming ranch...
December 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29177105/investigating-molecular-connections-of-non-alcoholic-fatty-liver-disease-with-associated-pathological-conditions-in-west-virginia-for-biomarker-analysis
#4
Dana L Sharma, Hari Vishal Lakhani, Rebecca L Klug, Brian Snoad, Rawan El-Hamdani, Joseph I Shapiro, Komal Sodhi
Non-alcoholic fatty liver disease (NAFLD) is a disease characterized by a steatosis of the liver that may progress to more serious pathological conditions including: nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. As the prevalence of NAFLD has increased worldwide in recent years, pathophysiology and risk factors associated with disease progression of NAFLD are at the focus of many studies. NAFLD is related to and shares common serum biomarkers with cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), obesity, and metabolic syndrome (MetS)...
October 2017: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/29133084/mri-for-the-measurement-of-liver-iron-content-and-for-the-diagnosis-and-follow-up-of-iron-overload-disorders
#5
Anita Paisant, Gaspard d'Assignies, Elise Bannier, Edouard Bardou-Jacquet, Yves Gandon
MRI is now the reference method for detecting and quantifying hepatic and extrahepatic iron overload, regardless of its cause. The decrease of the hepatic signal is proportional to the amount of iron in the tissues. It is more pronounced with T2*-weighted gradient echo sequences. It increases proportionally with the strength of the magnetic field. Thus a 3-T MRI is be more sensitive and probably more accurate to detect a slight iron overload, as seen in dysmetabolic hepatosiderosis. Conversely, a 1.5-T MRI better estimates a high overload...
November 10, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29128938/liver-fibrosis-noninvasive-assessment-using-supersonic-shear-imaging-and-fib4-index-in-patients-with-non-alcoholic-fatty-liver-disease
#6
Hirohito Takeuchi, Katsutoshi Sugimoto, Hisashi Oshiro, Kunio Iwatsuka, Shin Kono, Yu Yoshimasu, Yoshitaka Kasai, Yoshihiro Furuichi, Kentaro Sakamaki, Takao Itoi
PURPOSE: Shear wave elastography (SWE) has been validated in chronic hepatitis C and B; however, limited data are available in non-alcoholic fatty liver disease (NAFLD). This study aimed to evaluate the accuracy of SWE and FIB4 index for the diagnosis of fibrosis in a cohort of consecutive patients with biopsy-proven NAFLD, and to evaluate the effects of other histologic parameters on SWE measurement. METHODS: Written informed consent was obtained from all patients, and this study was approved by our internal review board and ethics committee...
November 11, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/29091130/importance-of-liver-biopsy-in-the-diagnosis-of-lysosomal-acid-lipase-deficiency-a-case-report
#7
Adriana Maria Alves De Tommaso, Flávia Fonseca de Carvalho Barra, Gabriel Hessel, Carolina Araújo Moreno, Roberto Giugliani, Cecília Amélia Fazzio Escanhoela
OBJECTIVE: To describe a case of cholesteryl ester storage disease (CESD) and discuss the importance of liver biopsy for diagnosis. CASE DESCRIPTION: A female patient, aged two years and ten months, presented with an increased abdominal volume following hepatomegaly for four months. Abdominal ultrasound demonstrated hepatomegaly and hepatic steatosis. Laboratory tests showed elevated liver serum enzymes and dyslipidemia. Liver biopsy was consistent with CESD. COMMENTS: Although measuring enzyme activity is the gold standard for CESD diagnosis, liver biopsy is very helpful when investigating suspected cases of CESD, particularly upon other differential diagnoses to be considered...
October 30, 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/29076884/homocysteine-visceral-adiposity-related-novel-cardiometabolic-risk-factors-and-exaggerated-blood-pressure-response-to-the-exercise-treadmill-test
#8
Pinar Türker Duyuler, Serkan Duyuler, Mevlüt Demir, Özgül Uçar Elalmiş, Ümit Güray, Mehmet İleri
OBJECTIVE: Exaggerated blood pressure response to exercise is a risk factor for the development of future hypertension. In this study, we aimed to investigate the association between homocysteine, epicardial fat thickness, nonalcoholic hepatic steatosis, and exaggerated blood pressure response to exercise. PARTICIPANTS AND METHODS: We included 44 normotensive and 40 patients with exaggerated blood pressure response to exercise who have normal resting blood pressure and without a previous diagnosis of hypertension...
October 25, 2017: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/29060526/the-influence-of-hepatic-steatosis-on-the-evaluation-of-fibrosis-with-non-alcoholic-fatty-liver-disease-by-acoustic-radiation-force-impulse
#9
Yanrong Guo, Haoming Lin, Xinyu Zhang, Huiying Wen, Siping Chen, Xin Chen
Acoustic radiation force impulse (ARFI) elastography is a non-invasive method for the assessment of liver by measuring liver stiffness. The aim of this study is to evaluate the accuracy of ARFI for the diagnosis of liver fibrosis and to assess impact of steatosis on liver fibrosis stiffness measurement, in rats model of non-alcoholic fatty liver disease (NAFLD). The rat models were conducted in 59 rats. The right liver lobe was processed and embedded in a fabricated gelatin solution. Liver mechanics were measured using shear wave velocity (SWV) induced by acoustic radiation force...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29055916/the-great-chinese-famine-exposure-in-early-life-and-the-risk-of-nonalcoholic-fatty-liver-disease-in-adult-women
#10
Xiaoya Zheng, Wei Ren, Lilin Gong, Jian Long, Rong Luo, Yonghong Wang
INTRODUCTION AND AIM: Previous studies found famine exposure was associated with a higher risk of metabolic syndrome (MetS). In the study, we investigated the relationship between Chinese famine exposure and the risk of nonalcoholic fatty liver disease (NAFLD) in adult women. MATERIALS AND METHODS: Data were obtained from subjects via routine physical examinations in the Public Health Center of our hospital between 2011 and 2014. Women were categorized into the following three groups: control, prenatally exposed, and postnatally exposed...
October 16, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28991837/serum-osteocalcin-levels-in-children-with-nonalcoholic-fatty-liver-disease
#11
Saleh Amin, Doaa El Amrousy, Shaymaa Elrifaey, Rasha Gamal, Hossam Hodeib
OBJECTIVES: to investigate the relationship between osteocalcin and non alcoholic fatty liver disease (NAFLD) in obese children. METHOD: 60 obese children with NAFLD were taken as patient group and 60 non - NAFLD children with matches age, sex and BMI were taken as control group. Anthropometric measurements, abdominal ultrasonography for diagnosis and grading of NAFLD, and laboratory investigations in the form of liver function tests, lipid profile, fasting serum glucose and insulin, and serum osteocalcin levels were done for all children...
October 6, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28984055/daily-cannabis-and-reduced-risk-of-steatosis-in-human-immunodeficiency-virus-and-hepatitis-c-virus-co-infected-patients-anrs-co13-hepavih
#12
S Nordmann, A Vilotitch, P Roux, L Esterle, B Spire, F Marcellin, D Salmon-Ceron, F Dabis, J Chas, D Rey, L Wittkop, P Sogni, P Carrieri
Liver steatosis is common in human immunodeficiency virus (HIV)-hepatitis C virus (HCV)-co-infected patients. Some recent studies have found that cannabis use is negatively associated with insulin resistance in the general population and in HIV-HCV-co-infected patients. Given the causal link between insulin resistance and steatosis, we hypothesized that cannabis use has a positive impact on steatosis. Therefore, we aimed to study whether cannabis use in this population was associated with a reduced risk of steatosis, measured by ultrasound examination...
October 6, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28957871/comparison-of-correlations-between-lipid-profile-and-different-computed-tomography-fatty-liver-criteria-in-the-setting-of-incidentally-noted-fatty-liver-on-computed-tomography-examinations
#13
Anugayathri Jawahar, Beverly Gonzalez, Neelam Balasubramanian, William Adams, Ari Goldberg
PURPOSE: The aim of this study was to compare the correlations between computed tomography (CT) criteria for hepatic steatosis and lipid profile values when hepatic steatosis is incidentally detected. PARTICIPANTS AND METHODS: This is an institutional Review Board-approved, HIPPA-compliant, retrospective study of abdominal CT scans in 200 randomly selected patients who had either nonenhanced CT (NECT) or contrast-enhanced CT (CECT) studies with reported fatty liver...
September 27, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28935200/benefit-risk-of-intraoperative-liver-biopsy-during-bariatric-surgery-review-and-perspectives
#14
REVIEW
Sandrine Barbois, Catherine Arvieux, Vincent Leroy, Fabian Reche, Nathalie Stürm, Anne-Laure Borel
Nonalcoholic fatty liver disease (NAFLD) is a metabolic complication of obesity that encompasses a spectrum of conditions, including hepatic steatosis, nonalcoholic steatohepatitis (NASH), cirrhosis, and end-stage liver disease. Screening for NAFLD is important to limit progression, allow early detection of carcinoma, and follow the need for liver transplantation. Although noninvasive markers exist, hepatic histologic evaluation remains the gold standard for diagnosis. To reduce the risk of complications after liver biopsy but increase the accuracy of NAFLD diagnosis, hepatic tissue can be sampled during bariatric surgery...
August 14, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28931896/association-between-plasma-gamma-glutamyltransferase-fractions-and-metabolic-syndrome-among-hypertensive-patients
#15
Maria Franzini, Ilenia Scataglini, Angelo Ricchiuti, Vanna Fierabracci, Aldo Paolicchi, Alfonso Pompella, Giulia Dell'Omo, Roberto Pedrinelli, Alessandro Corti
Among the risk factors associated to metabolic syndrome (MetS), hypertension shows the highest prevalence in Italy. We investigated the relationship between the newly identified serum γ-glutamyltransferase (GGT) fractions, b- s- m- f-GGT, and risk factors associated to MetS in hypertensive patients. A total of ninety-five consecutive hypertensive patients were enrolled. GGT fractions were analysed by gel-filtration chromatography, and hepatic steatosis was evaluated by ultrasound. MetS was diagnosed in 36% of patients...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28901345/-acute-alcoholic-hepatitis
#16
Gianni Testino, Emanuele Scafato, Valentino Patussi
Chronic alcohol related liver disease is characterized by a cascade of events defined as follows: steatosis, steatohepatitis/steatofibrosi, cirrhosis and hepatocellular carcinoma. On one of these histologic patterns may overlap acute alcoholic hepatitis (AAE) (mild, moderate, severe). Severe AAE can cause a severe clinical picture: jaundice with a duration of less than three months, jaundice in the first decompensation event, serum bilirubin higher than 5 mg/dL, ratio AST/ALT >2:1, AST less than 500 IU/L ALT <300 IU/L, neutrophil leukocytosis and increased GGT...
September 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28830448/significant-decrease-of-saturation-index-in-erythrocytes-membrane-from-subjects-with-non-alcoholic-fatty-liver-disease-nafld
#17
Maria Notarnicola, Maria Gabriella Caruso, Valeria Tutino, Caterina Bonfiglio, Raffaele Cozzolongo, Vito Giannuzzi, Valentina De Nunzio, Giampiero De Leonardis, Daniela I Abbrescia, Isabella Franco, Vincenza Intini, Antonella Mirizzi, Alberto R Osella
BACKGROUND: The lipidomic profiling of erythrocyte membranes is expected to provide a peculiar scenario at molecular level of metabolic and nutritional pathways which may influence the lipid balance and the adaptation and homeostasis of the organism. Considering that lipid accumulation in the cell is important in promoting tissue inflammation, the purpose of this study is to analyze the fatty acid profile in red blood cell membranes of patients with Non-Alcoholic Fatty Liver Disease (NAFLD), in order to identify and validate membrane profiles possibly associated with the degree of hepatic damage...
August 23, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28823009/proton-pump-inhibitors-as-risk-factor-for-metabolic-syndrome-and-hepatic-steatosis-in-coeliac-disease-patients-on-gluten-free-diet
#18
Nicola Imperatore, Raffaella Tortora, Anna Testa, Nicolò Gerbino, Nicola Caporaso, Antonio Rispo
BACKGROUND: Recent research has shown that patients with coeliac disease (CD) are at risk of developing metabolic syndrome (MS) and hepatic steatosis (HS) after commencing a gluten-free diet (GFD). This study aimed to evaluate the predictive factors for MS and HS in CD after 1 year of GFD. METHODS: All consecutive newly diagnosed CD patients were enrolled. We prospectively collected data about BMI; waist circumference; blood pressure; cholesterol; triglycerides, glucose and insulin blood levels; insulin resistance (through the homeostatic model assessment HOMA-IR) and treatment with proton pump inhibitors (PPI)...
August 19, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28800087/imaging-features-of-non-alcoholic-fatty-liver-disease-in-children-and-adolescents
#19
REVIEW
Michele Di Martino, Kameliya Koryukova, Mario Bezzi, Carlo Catalano
Non-invasive diagnosis and quantification of liver steatosis is important to overcome limits of liver biopsy, in order to follow up patients during their therapy and to establish a reference standard that can be used in clinical trials and longitudinal studies. Imaging offers several methods in this setting: ultrasound, which is the cheapest technique and easy to perform; magnetic resonance spectroscopy (MRS), which reflects the real content of triglycerides in a specific volume; and proton density fat fraction (PDFF) magnetic resonance, which is a simple method that reflects the distribution of the fat in the whole liver...
August 11, 2017: Children
https://www.readbyqxmd.com/read/28741275/fatty-liver-decreases-the-risk-of-liver-metastasis-in-patients-with-breast-cancer-a-two-center-cohort-study
#20
Wenyu Wu, Jie Chen, Weilin Ye, Xi Li, Jian Zhang
BACKGROUND: The influence of hepatic steatosis (HS) on liver metastasis in patients with non-metastatic breast cancer (BC) remains unclear. The aim of this study was to clarify the relationship between HS and liver metastasis in non-metastatic BC patients. METHODS: Patients who underwent treatment for BC at two affiliated hospitals of Southern Medical University, between January 1, 2005 and December 31, 2015, were retrospectively reviewed. BC patients were divided into the study and control groups based on the presence of HS...
July 24, 2017: Breast Cancer Research and Treatment
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