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https://www.readbyqxmd.com/read/28323838/bupropion-for-the-treatment-of-apathy-in-huntington-s-disease-a-multicenter-randomised-double-blind-placebo-controlled-prospective-crossover-trial
#1
Harald Gelderblom, Torsten Wüstenberg, Tim McLean, Lisanne Mütze, Wilhelm Fischer, Carsten Saft, Rainer Hoffmann, Sigurd Süssmuth, Peter Schlattmann, Erik van Duijn, Bernhard Landwehrmeyer, Josef Priller
OBJECTIVE: To evaluate the efficacy and safety of bupropion in the treatment of apathy in Huntington's disease (HD). METHODS: In this phase 2b multicentre, double-blind, placebo-controlled crossover trial, individuals with HD and clinical signs of apathy according to the Structured Clinical Interview for Apathy-Dementia (SCIA-D), but not depression (n = 40) were randomized to receive either bupropion 150/300mg or placebo daily for 10 weeks. The primary outcome parameter was a significant change of the Apathy Evaluation Scale (AES) score after ten weeks of treatment as judged by an informant (AES-I) living in close proximity with the study participant...
2017: PloS One
https://www.readbyqxmd.com/read/28303968/sex-differences-in-dna-methylation-of-the-cord-blood-are-related-to-sex-bias-psychiatric-diseases
#2
Mariana Maschietto, Laura Caroline Bastos, Ana Carolina Tahira, Elen Pereira Bastos, Veronica Luiza Vale Euclydes, Alexandra Brentani, Günther Fink, Angelica de Baumont, Aloísio Felipe-Silva, Rossana Pulcineli Vieira Francisco, Gisele Gouveia, Sandra Josefina Ferraz Ellero Grisi, Ana Maria Ulhoa Escobar, Carlos Alberto Moreira-Filho, Guilherme Vanoni Polanczyk, Euripedes Constantino Miguel, Helena Brentani
Sex differences in the prevalence of psychiatric disorders are well documented, with exposure to stress during gestation differentially impacting females and males. We explored sex-specific DNA methylation in the cord blood of 39 females and 32 males born at term and with appropriate weight at birth regarding their potential connection to psychiatric outcomes. Mothers were interviewed to gather information about environmental factors (gestational exposure) that could interfere with the methylation profiles in the newborns...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28302595/behavioral-indicators-on-a-mobile-sensing-platform-predict-clinically-validated-psychiatric-symptoms-of-mood-and-anxiety-disorders
#3
Skyler Place, Danielle Blanch-Hartigan, Channah Rubin, Cristina Gorrostieta, Caroline Mead, John Kane, Brian P Marx, Joshua Feast, Thilo Deckersbach, Alex Sandy Pentland, Andrew Nierenberg, Ali Azarbayejani
BACKGROUND: There is a critical need for real-time tracking of behavioral indicators of mental disorders. Mobile sensing platforms that objectively and noninvasively collect, store, and analyze behavioral indicators have not yet been clinically validated or scalable. OBJECTIVE: The aim of our study was to report on models of clinical symptoms for post-traumatic stress disorder (PTSD) and depression derived from a scalable mobile sensing platform. METHODS: A total of 73 participants (67% [49/73] male, 48% [35/73] non-Hispanic white, 33% [24/73] veteran status) who reported at least one symptom of PTSD or depression completed a 12-week field trial...
March 16, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28301561/treating-major-depression-with-yoga-a-prospective-randomized-controlled-pilot-trial
#4
Sudha Prathikanti, Renee Rivera, Ashly Cochran, Jose Gabriel Tungol, Nima Fayazmanesh, Eva Weinmann
BACKGROUND: Conventional pharmacotherapies and psychotherapies for major depression are associated with limited adherence to care and relatively low remission rates. Yoga may offer an alternative treatment option, but rigorous studies are few. This randomized controlled trial with blinded outcome assessors examined an 8-week hatha yoga intervention as mono-therapy for mild-to-moderate major depression. METHODS: Investigators recruited 38 adults in San Francisco meeting criteria for major depression of mild-to-moderate severity, per structured psychiatric interview and scores of 14-28 on Beck Depression Inventory-II (BDI)...
2017: PloS One
https://www.readbyqxmd.com/read/28301180/borderline-personality-disorder-and-mental-health-care-utilization-the-role-of-self-harm
#5
Randy A Sansone, Martin Sellbom, Douglas A Songer
The current study examined the associations for borderline personality disorder (BPD) and a specific trait of the disorder, self-harm, with mental health care utilization. Our sample consisted of 145 psychiatric inpatients who completed 3 measures of BPD (Personality Diagnostic Questionnaire-4 [PDQ-4], McLean Screening Inventory for borderline personality disorder [MSI-BPD], Structured Clinical Interview for DSM-IV Axis II Disorders-Personality Questionnaire [SCID-II-PQ]) and the Self-Harm Inventory (SHI). In relationship to mental health care utilization, the correlation for the SHI was significantly larger than those for the PDQ-4, MSI-BPD, or SCID-II-PQ...
March 16, 2017: Personality Disorders
https://www.readbyqxmd.com/read/28295142/creation-of-an-interprofessional-teledementia-clinic-for-rural-veterans-preliminary-data
#6
Becky B Powers, Marcia C Homer, Natalia Morone, Natali Edmonds, Michelle I Rossi
The teledementia clinic is a new model of care that expands the reach of specialized geriatric and dementia care using clinical video telehealth (CVT) to rural veterans, who frequently lack access to specialty care. The clinic is a Veterans Affairs (VA) Geriatric Research, Education, and Clinical Center clinical demonstration project. It is located in the Pittsburgh VA Healthcare System tertiary referral hospital and serves veterans in affiliated rural community-based outpatient clinics (CBOCs). Rural CBOC primary care providers refer clinic patients, or referral is according to previous cognitive impairment diagnosis in a VAPHS geriatric clinic...
March 10, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28293623/patients-experience-of-winter-depression-and-light-room-treatment
#7
Cecilia Rastad, Lennart Wetterberg, Cathrin Martin
Background. There is a need for more knowledge on the effects of light room treatment in patients with seasonal affective disorder and to explore patients' subjective experience of the disease and the treatment. Methods. This was a descriptive and explorative study applying qualitative content analysis. A purposeful sample of 18 psychiatric outpatients with a major depressive disorder with a seasonal pattern and a pretreatment score ≥12 on the 9-item Montgomery-Åsberg Depression self-rating scale was included (10 women and 8 men, aged 24-65 years)...
2017: Psychiatry Journal
https://www.readbyqxmd.com/read/28292624/differential-neuropsychological-functioning-between-adolescents-with-attention-deficit-hyperactivity-disorder-with-and-without-conduct-disorder
#8
Yu-Ju Lin, Susan Shur-Fen Gau
BACKGROUND/PURPOSE: This study aimed to evaluate neuropsychological functioning of attention-deficit/hyperactivity disorder (ADHD) with and without comorbidities of oppositional defiant disorder (ODD) and/or conduct disorder (CD) and the mediation effects of the neuropsychological functions in the relationship between ADHD and ODD/CD symptoms to increase our understanding about these frequently co-occurring disorders. METHODS: Adolescents aged 11-18 years were interviewed by the Kiddie epidemiologic version of the Schedule for Affective Disorders and Schizophrenia to confirm their previous and current ADHD status and other psychiatric diagnoses...
March 11, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28292223/mechanism-of-action-for-obtaining-job-offers-with-virtual-reality-job-interview-training
#9
Matthew J Smith, Justin D Smith, Michael F Fleming, Neil Jordan, C Hendricks Brown, Laura Humm, Dale Olsen, Morris D Bell
OBJECTIVE: Four randomized controlled trials revealed that virtual-reality job interview training (VR-JIT) improved interviewing skills and the odds of obtaining a job offer among trainees with severe mental illness or autism spectrum disorder. This study assessed whether postintervention interviewing skills mediated the relationship between completion of virtual interviews and receiving job offers by six-month follow-up. METHODS: VR-JIT trainees (N=79) completed pre- and posttest mock interviews and a brief survey approximately six months later to assess whether they received a job offer...
March 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28291974/comorbid-depression-and-suicide-ideation-in-patients-with-combat-related-ptsd-the-role-of-temperament-character-and-trait-impulsivity
#10
Nenad Jakšić, Branka Aukst Margetić, Darko Marčinko
BACKGROUND: War veterans with PTSD have a high chance of developing major depressive disorder (MDD) at some point, while they can also exhibit increased suicidal tendencies. The primary goal of this research was to investigate whether personality dimensions, including temperament, character, and trait impulsivity, were associated with comorbid MDD, as well as with suicidal ideation in psychiatric patients suffering from combat-related PTSD. SUBJECTS AND METHODS: The sample consisted of 148 Croatian male war veterans (mean age 49...
March 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28291691/explanatory-model-of-illness-of-the-patients-with-schizophrenia-and-the-role-of-educational-intervention
#11
Naila Riaz Awan, Syeda Farhana Jehangir, Muhammad Irfan, Farooq Naeem, Saeed Farooq
This randomized controlled trial was conducted at Department of Psychiatry, Lady Reading Hospital, Peshawar from February to August 2015 to explore beliefs and concepts of patients with schizophrenia about their illness and to find out the effectiveness of structured educational intervention in changing the explanatory models of illness of the patients and in their symptoms reduction. One hundred and three patients were recruited in the trial who were randomly assigned to two groups i.e., Experimental (n=53) and Control i...
March 10, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28290763/psychosocial-risk-factors-and-treatment-of-new-onset-and-recurrent-depression-during-the-post-partum-period
#12
Pirjo Kettunen, Jukka Hintikka
BACKGROUND: When developing maternity care services, it is important to know how psychosocial factors affect the course of post-partum depression (PPD), and how depressed mothers are treated. AIMS: The aim of this study is to assess how adverse childhood experiences, poor present support and violence, and low socioeconomic status (SES) associate with PPD, specifically in new onset and recurrent post-partum depression. The second aim is to assess the treatment received for PPD...
March 14, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28290253/the-interaction-between-parenting-and-children-s-cortisol-reactivity-at-age-3-predicts-increases-in-children-s-internalizing-and-externalizing-symptoms-at-age-6
#13
Chelsey S Barrios, Sara J Bufferd, Daniel N Klein, Lea R Dougherty
Little is known about the role of stress reactivity in the emergence of psychopathology across early childhood. In this longitudinal study, we tested the hypothesis that child cortisol reactivity at age 3 moderates associations between early parenting and children's internalizing and externalizing symptoms from age 3 to age 6. One hundred and sixty children were assessed at age 3, and 135 children were reassessed at age 6. At age 3, we exposed children to stress-inducing laboratory tasks, during which we obtained four salivary cortisol samples, and parental hostility was assessed using an observational parent-child interaction task...
March 14, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28287865/recovery-oriented-psychiatric-nursing-in-south-korea-a-hybrid-concept-analysis
#14
Suyon Baek, Sunah Kim
The purpose of this study is to examine the attributes and verify the definition of the recovery-oriented psychiatric nursing concept using the hybrid model suggested by Schwartz-Barcott and Kim ( 2000 ). In the theoretical analysis phase, a literature search was conducted and data were collected using the Pubmed, CINAHL, and Google Scholar databases. This study considered of 7 empirical studies, 21 guidelines, 12 instruments, 2 related theories, 3 practical models, and 2 intervention programs. In the fieldwork phase, this study performed in-depth interviews with nine psychiatric nurses...
March 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28287675/psychiatric-nurses-views-on-caring-patients-and-canine-companions
#15
Camille King
Psychiatric nurses are expert care providers for individuals with mental health needs. The art of caring spans across multiple species, is important to understand, and is universal whether intentions are toward individuals or animals. Pets are often cared for and viewed as family members. The current research examined psychiatric nurses' views on the similarities and differences of caring for patients and their pet dogs. Twenty-five nurses were interviewed. Similarities of caring for patients and canines included trusting relationships, companionship, daily basic needs, and improved communication through monitored body language...
March 1, 2017: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/28284362/-reorganising-a-department-of-psychiatry-according-to-recovery-principles-a-pilot-study-with-mixed-method-design
#16
Gisbert Eikmeier, Luciana Degano Kieser, Mirjam Paap, Jörg Utschakowski, Angelika Lacroix
Considering the impact of mental disorders, control and evaluation of treatment programs are important topics. Here, we report on a pilot study composed of a qualitative and a quantitative part to monitor the recovery-oriented reorganisation of a psychiatric department. For this purpose 13 and 15, respectively, stakeholders of the change management were interviewed between 2012 (T1) and 2014 (T2). Moreover, patients and staff were asked to complete a German version of the Recovery Self Assessment (RSA) questionnaire...
February 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28284087/evaluating-the-motor-slowing-hypothesis-of-depression
#17
Robert D Shura, Jared A Rowland, Sarah L Martindale, Timothy W Brearly, Mariah B Delahanty, Holly M Miskey
The purpose of this study was to evaluate the hypothesis that processing speed deficits are the primary cognitive deficits in those with depression, consistent with the motor slowing hypothesis. Participants (n=223) were research volunteers who served in the US military since September 11, 2001, and denied a history of significant brain injuries. Depression was measured using a structured interview, the Personality Assessment Inventory (PAI), and the Beck Depression Inventory-II (BDI-II). Outcomes included performance on 10 processing speed variables...
January 27, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28282630/differences-in-the-symptom-profile-of-methamphetamine-related-psychosis-and-primary-psychotic-disorders
#18
Rebecca McKetin, Amanda L Baker, Sharon Dawe, Alexandra Voce, Dan I Lubman
We examined the lifetime experience of hallucinations and delusions associated with transient methamphetamine-related psychosis (MAP), persistent MAP and primary psychosis among a cohort of dependent methamphetamine users. Participants were classified as having (a) no current psychotic symptoms, (n=110); (b) psychotic symptoms only when using methamphetamine (transient MAP, n=85); (c) psychotic symptoms both when using methamphetamine and when abstaining from methamphetamine (persistent MAP, n=37), or (d) meeting DSM-IV criteria for lifetime schizophrenia or mania (primary psychosis, n=52)...
February 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28282083/-first-person-narratives-is-there-anything-new-in-them-for-a-mental-health-professional
#19
Martín Agrest
Recovery narratives and first-person accounts of people living with mental disorders are not really new. Nevertheless, scarce attention has been paid to them by mental health professionals. What is it like to live with a mental disorder, receive a diagnosis, or hide previous experiences of treatment in mental health centers or with psychiatric medication in the context of a job interview or trying to start a relationship with another person? What is it like to learn new coping strategies, to be able to contribute to society and to assume an identity that neither denies the pathology nor is reduced to it? These narratives are analysed in order to stablish both the novelty in their production, and who and how could benefit from them...
July 2016: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/28281942/pituitary-hyperplasia-in-a-female-patient-with-a-severe-childhood-abuse-history
#20
Andrea Fragoso Perozo, Tiago Figueiredo, Michelle Botelho Caarls, Daniel Segenreich, Leonardo Vieira Neto
A 24-year-old Caucasian female patient was referred to our endocrinology service to investigate a structural magnetic resonance imaging (sMRI) finding of "pituitary mass". The first two sMRI were identified as pituitary adenoma but the following two exams suggested the possibility of pituitary hyperplasia (PH). The patient was referred to our service for diagnostic clarification and therapy due to the divergence in sMRI reports and the surgical procedure indicated by the neurosurgical team of the other institution...
March 10, 2017: Journal of Trauma & Dissociation
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