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https://www.readbyqxmd.com/read/29784018/adding-colchicine-to-immunosuppressive-treatments-a-potential-option-for-biologics-refractory-adult-onset-still-s-disease
#1
Tomoyuki Asano, Makiko Yashiro Furuya, Shuzo Sato, Hiroko Kobayashi, Hiroshi Watanabe, Eiji Suzuki, Kiyoshi Migita
BACKGROUND: Adult-onset Still's disease (AOSD) is a rare inflammatory disorder characterized by the classical triad of daily spiking fever, arthritis, and typical salmon-colored rash. Resistance to first-line corticosteroids and second-line disease modified anti-rheumatic-drugs defines refractory AOSD, which mostly includes the polycyclic or chronic courses of the disease. Anti-cytokine therapies are recommended in AOSD patients who are refractory to traditional treatments. This is the first report on the efficacy of colchicine in a patient with AOSD which was refractory to immunosuppressive treatments including biologics...
May 21, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29778090/massive-pericardial-effusion-without-cardiac-tamponade-due-to-subclinical-hypothyroidism-hashimoto-s-disease
#2
Panteleimon E Papakonstantinou, Nikolaos Gourniezakis, Christos Skiadas, Alexandros Patrianakos, Achilleas Gikas
CONTEXT: Hypothyroidism is a significant cause of pericardial effusion. However, large pericardial effusions due to hypothyroidism are extremely rare. Hormone replacement therapy is the cornerstone of treatment for hypothyroidism and regular follow-up of patients after initiation of the therapy is indicated. Herein, the case of a 70-year-old woman with a massive pericardial effusion due to Hashimoto's disease is presented. ISSUES: A 70-year-old female from a rural village on the island of Crete, Greece, was admitted to our hospital due to a urinary tract infection...
May 2018: Rural and Remote Health
https://www.readbyqxmd.com/read/29769485/changes-of-peak-expiratory-flow-rate-in-adult-asthmatic-patient
#3
S Nasreen, A Nessa, F Islam, A Khanam, R Sultana, R Rahman, M Hossain
Asthma is a common pulmonary disorder characterizerized by airway inflammation, airway- hyper reactivity, and reversible airflow obstruction. The classic triad of symptoms is wheezing, chronic episodic dyspnea and chronic cough. The prevalence of asthma increased steadily over the latter part of the last century, first in the developed and then in the developing world. The number of people with asthma in the world may be as high as 334 million. Asthma in Bangladesh appears to be a substantial public health problem: an estimated 11...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29722578/a-review-of-prevention-diagnosis-and-treatment-of-relative-energy-deficiency-in-sport-red-s-in-artistic-synchronized-swimming
#4
Sherry Robertson, Margo Mountjoy
The syndrome Relative Energy Deficiency in Sport (RED-S) is a clinical entity characterized by low energy availability (LEA), which can negatively affect the health and performance of both male and female athletes. The underlying mechanism of RED-S is an inadequacy of dietary energy to support optimal health and performance. This syndrome refers to impaired physiological function including metabolic rate, menstrual function, bone health, immunity, protein synthesis, and cardiovascular health, with psychological consequences which can either precede (through restrictive dietary habits) or result from RED-S...
May 3, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29714445/pooled-analysis-of-163-published-tuberculous-peritonitis-cases-from-turkey
#5
Bedia Mutay Suntur, Ferit Kuşçu
Background/aim: Tuberculous peritonitis may be difficult to diagnose due to its insidious and variable clinical manifestations as well as characteristics similar to malignancy. In this study, case reports from Turkey over the last 10 years were reviewed systematically using pooled analysis. Materials and methods: Thirty-four suitable articles were found and 163 tuberculous peritonitis cases were included in the study. Results: The mean age was 34.1 years (17–79 years), and 146 (98.6%) of the patients were female and 17 (10...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29686795/rare-cause-of-gastric-outlet-obstruction
#6
Sonal Gandhi, Niraj Jani
Bouveret's syndrome is a rare cause of gastric outlet obstruction. The stones enter the small bowel via cholecysto-enteric fistula. The most common presenting symptoms are abdominal pain, nausea and vomiting. The gold standard diagnostic test isesophagogastroduodenoscopy (EGD). Rigler's triad on abdominal x-ray is classic. CT scan findings are pneumobilia, cholecystoduodenal fistula and a gallstone in the duodenum. We present a case of a 75-year-old female who presents with 3 week history of nausea, vomiting, and diffuse abdominal pain...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29671493/the-female-athlete-triad-recommendations-for-management
#7
Rachel Chamberlain
No abstract text is available yet for this article.
April 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29668642/operative-treatment-of-terrible-triad-of-the-elbow-with-a-modified-pugh-standard-protocol-retrospective-analysis-of-a-prospective-cohort
#8
Guanyi Liu, Weihu Ma, Ming Li, Jianxiang Feng, Rongming Xu, Zhijun Pan
The aim of the present study was to investigate the efficacy of the surgical treatment of terrible triad injuries of the elbow using a modified standard surgical approach, and treatment determined by the mode and mechanism of injury, and intraoperative findings.The study was a retrospective analysis of a prospective cohort of patients presenting with terrible triad injuries of the elbow, who underwent surgical treatment between July 2009 and January 2014. All patients were treated surgically according to a modified Pugh standard protocol...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29607594/management-of-the-female-athlete-triad
#9
Sayaka Nose-Ogura, Miyuki Harada, Osamu Hiraike, Yutaka Osuga, Tomoyuki Fujii
The female athlete triad (FAT) is defined by the American College of Sports Medicine (ACSM) as low energy availability (low EA), functional hypothalamic amenorrhoea and osteoporosis. In low EA, lutein dysfunction first develops, followed by anovulation and, subsequently, oligomenorrhea, leading to amenorrhea. Moreover, low estradiol concentrations due to amenorrhea decrease bone mineral density (BMD). In athletes with one of the factors of FAT, the risk of a stress fracture is 2.4-4.9 times higher and may increase the risk of fracture throughout the lifespan...
April 2, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29607470/obesity-indices-and-peripheral-artery-disease-measured-by-ankle-brachial-index-in-nigerian-out-patients
#10
E M Umuerri, A O Obasohan
BACKGROUND: Peripheral artery disease (PAD), an important component of the cardiovascular triad, has been linked with obesity as one of the risk factors for its development. The risk posed by obesity however varies depending on the indices measured. METHODS: We compared the relationship of measures of central and visceral obesity (waist circumference (WC) and waist-hip ratio (WHR) versus that of general obesity (body mass index (BMI) in the development of PAD among Nigerians with hypertension and/or diabetes mellitus...
January 2018: West African Journal of Medicine
https://www.readbyqxmd.com/read/29603932/age-and-gender-effects-on-perceptual-color-scaling-using-triadic-comparisons
#11
David Bimler, Valérie Bonnardel
We examined age and gender as possible determinants of individual differences in triadic judgments of color dissimilarity. Seventy triads were constructed from 21 equal-lightness Munsell samples, at equal hue steps, forming a rough ellipse in the CIE-LAB plane, and presented to 51 males and 53 females (half young, half elderly adults) who indicated each triad's "odd one out." Principal component analysis followed by multidimensional scaling (MDS) revealed group differences in judgment reliability, with better performance for female and younger groups...
April 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29520293/analysis-of-parent-of-origin-effects-on-the-x-chromosome-in-asian-and-european-orofacial-cleft-triads-identifies-associations-with-dmd-fgf13-egfl6-and-additional-loci-at-xp22-2
#12
Øivind Skare, Rolv T Lie, Øystein A Haaland, Miriam Gjerdevik, Julia Romanowska, Håkon K Gjessing, Astanand Jugessur
Background: Although both the mother's and father's alleles are present in the offspring, they may not operate at the same level. These parent-of-origin (PoO) effects have not yet been explored on the X chromosome, which motivated us to develop new methods for detecting such effects. Orofacial clefts (OFCs) exhibit sex-specific differences in prevalence and are examples of traits where a search for various types of effects on the X chromosome might be relevant. Materials and Methods: We upgraded our R-package Haplin to enable genome-wide analyses of PoO effects, as well as power simulations for different statistical models...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29502302/sleep-duration-body-composition-dietary-profile-and-eating-behaviours-among-children-and-adolescents-a-comparison-between-portuguese-acrobatic-gymnasts
#13
Maria-Raquel G Silva, Hugo-Henrique Silva, Teresa Paiva
Sleep, body composition and dietary intake are crucial for athletes' health and performance but have never been investigated in acrobatic gymnasts. Thus, this study aimed to evaluate sleep, body composition, dietary intake and eating behaviours of acrobatic gymnasts. Using a cross-sectional study, 82 Portuguese acrobatic gymnasts (12.8 ± 3.1 years, 61 females and 21 males) were evaluated during the competitive period to collect training data, sleep duration, body composition, dietary intake and eating behaviours before, during and after practices...
March 3, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29485333/female-athlete-triad-triad-relative-energy-deficiency-in-sport-red-s-a-perspective-interview-with-professor-barbara-drinkwater
#14
Susan Carter
No abstract text is available yet for this article.
February 27, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29477862/the-brain-lung-thyroid-syndrome-blts-a-novel-deletion-in-chromosome-14q13-2-q21-1-expands-the-phenotype-to-humoral-immunodeficiency
#15
Beatriz Villafuerte, Daniel Natera-de-Benito, Aidy González, María A Mori, María Palomares, Julián Nevado, Sixto García-Miñaur, Pablo Lapunzina, Luis I González-Granado, Luis M Allende, José C Moreno
Genetic defects of NKX2-1 are classically associated with hypothyroidism, benign chorea and neonatal respiratory distress. The purpose of this study was to identify the genetic pathogenesis of the "NKX2-1 triad" in a 10 year-old female presenting additional features barely described in the disorder. In the neonatal period, she presented with generalized hypotonia and respiratory distress, with later episodes of frequent wheezing. At 3 month-age developmental dysplasia of the hip was diagnosed and at 10 months, primary hypothyroidism was detected and treated...
February 22, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29472999/ontogeny-of-long-range-vocalizations-in-a-neotropical-fossorial-rodent-the-anillaco-tuco-tuco-ctenomys-sp
#16
Juan Pablo Amaya, Juan Ignacio Areta
Tuco-tucos ( Ctenomys spp.) are subterranean rodents that produce territorial, high intensity long-range vocalizations (LRVs) of broadband and low frequency that are essential for long-distance communication between individuals in different tunnel systems. Despite their importance, the development of LRVs remains poorly understood. In adult Anillaco Tuco-Tucos ( Ctenomys sp.) the LRV is composed by two types of syllables (series and individual notes) that are repeated a variable number of times. We studied the development of the LRVs in eight juveniles of the Anillaco Tuco-Tuco ranging from 14-28 to 104-118 days after birth...
2018: PeerJ
https://www.readbyqxmd.com/read/29471055/brain-insulin-signalling-glucose-metabolism-and-females-reproductive-aging-a-dangerous-triad-in-alzheimer-s-disease
#17
REVIEW
A I Duarte, M S Santos, C R Oliveira, P I Moreira
Alzheimer's disease (AD) constitutes a major socioeconomic challenge due to its disabling features and the rise in prevalence (especially among (peri)menopausal women and type 2 diabetes patients). The precise etiopathogenesis of AD remains poorly understood. Importantly, its neurodegenerative perspective has been challenged towards a more "systemic" view. Amyloid-β (Aβ) and hyperphosphorylated Tau protein (P-Tau) (the main AD neuropathological features) affect and are affected by peripheral and brain insulin signalling dysfunction, leading to glucose dysmetabolism, synaptic loss and AD-related cognitive deficits...
February 20, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29457386/-treatment-of-habitual-dislocation-of-patella-with-reconstruction-of-medial-patellofemoral-ligament-combined-with-release-of-lateral-retinaculum-and-medial-transfer-and-advancement-of-tibial-tuberosity-under-arthroscopy
#18
Li-Chuang Wu, Hai-Bo Zhou, Chao Zhang, Lei Chen, Cai-Long Liu
OBJECTIVE: To study clinical effects of triad operation including reconstruction of medial patellofemoral ligament, release of lateral retinaculum, Fulkerson tibial tubercle osteotomy, medial transfer and advancement under arthroscopy for the treatment of habitual dislocation of patella. METHODS: From March 2010 to May 2016, 35 patients with habitual patellar dislocation were treated with the triad operation, including 14 males, 21 females, ranging in age from 18 to 38 years old, with an average of 25...
November 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29442062/gallstone-ileus-in-a-ninety-two-years-old-colecistectomized-patient-after-endoscopic-biliary-sphincterotomy-a-case-report
#19
S Fedele, P Lobascio, G Carbotta, G Balducci, R Laforgia, M G Sederino, M Minafra, A Delvecchio, N Palasciano
INTRODUCTION: Gallstone ileus is an uncommon condition of mechanical bowel obstruction caused by the passage of a gallstone into the bowel. It occurs more frequently in female patients older than 65 years and often for a biliary-enteric fistula. The pathognomonic features of gallstone ileus - the Rigler's triad - are pneumobilia, ectopic gallstone and bowel obstruction. Less commonly, a gallstone may enter the intestinal lumen through the common bile duct, after endoscopic retrograde cholangiopancreatography, and very rarely in colecistectomized patient...
November 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29437776/rapid-whole-genome-sequencing-identifies-a-novel-aire-variant-associated-with-autoimmune-polyendocrine-syndrome-type-1
#20
Erica Sanford, Kelly Watkins, Shareef Nahas, Michael Gottschalk, Nicole Coufal, Lauge Farnaes, David Dimmock, Stephen Kingsmore, Rcigm Investigators
Autoimmune polyendocrine syndrome type 1 (APS1; OMIM #240300), also referred to as autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), is a rare monogenic disorder caused by mutations in the autoimmune regulator (AIRE) gene. APS1 is classically characterized by a triad of chronic mucocutaneous candidiasis, autoimmune hypoparathyroidism, and autoimmune adrenocortical insufficiency. We report a five-year-old female who presented with symptoms of tetany due to hypocalcemia and was subsequently found to be secondary to hypoparathyroidism...
February 1, 2018: Cold Spring Harbor Molecular Case Studies
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