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https://www.readbyqxmd.com/read/29655834/metformin-use-associates-with-longer-progression-free-survival-of-patients-with-diabetes-and-pancreatic-neuroendocrine-tumors-receiving-everolimus-and-or-somatostatin-analogues
#1
Sara Pusceddu, Claudio Vernieri, Massimo Di Maio, Riccardo Marconcini, Francesca Spada, Sara Massironi, Toni Ibrahim, Maria Pia Brizzi, Davide Campana, Antongiulio Faggiano, Dario Giuffrida, Maria Rinzivillo, Sara Cingarlini, Francesca Aroldi, Lorenzo Antonuzzo, Rossana Berardi, Laura Catena, Chiara De Divitiis, Paola Ermacora, Vittorio Perfetti, Annalisa Fontana, Paola Razzore, Carlo Carnaghi, Maria Vittoria Davì, Carolina Cauchi, Marilina Duro, Sergio Ricci, Nicola Fazio, Federica Cavalcoli, Alberto Bongiovanni, Anna La Salvia, Nicole Brighi, Annamaria Colao, Ivana Puliafito, Francesco Panzuto, Silvia Ortolani, Alberto Zaniboni, Francesco Di Costanzo, Mariangela Torniai, Emilio Bajetta, Salvatore Tafuto, Silvio Ken Garattini, Daniela Femia, Natalie Prinzi, Laura Concas, Giuseppe Lo Russo, Massimo Milione, Luca Giacomelli, Roberto Buzzoni, Gianfranco Delle Fave, Vincenzo Mazzaferro, Filippo de Braud
BACKGROUND & AIMS: Metformin seems to have anti-cancer effects. However, it is not clear whether use of glycemia and metformin affect outcomes of patients with advanced pancreatic neuroendocrine tumors (pNETs). We investigated the association between glycemia and progression-free survival (PFS) of patients with NETs treated with everolimus and/or somatostatin analogues, as well as the association between metformin use and PFS time. METHODS: We performed a retrospective analysis of 445 patients with advanced pNET treated at 24 medical centers in Italy, from 1999 through 2015...
April 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29652893/glucose-sensor-augmented-continuous-subcutaneous-insulin-infusion-in-patients-with-diabetic-gastroparesis-an-open-label-pilot-prospective-study
#2
Jorge Calles-Escandón, Kenneth L Koch, William L Hasler, Mark L Van Natta, Pankaj J Pasricha, James Tonascia, Henry P Parkman, Frank Hamilton, William H Herman, Marina Basina, Bruce Buckingham, Karen Earle, Kjersti Kirkeby, Kristen Hairston, Tamis Bright, Amy E Rothberg, Andrew T Kraftson, Elias S Siraj, Angela Subauste, Linda A Lee, Thomas L Abell, Richard W McCallum, Irene Sarosiek, Linda Nguyen, Ronnie Fass, William J Snape, Ivana A Vaughn, Laura A Miriel, Gianrico Farrugia
Erratic blood glucose levels can be a cause and consequence of delayed gastric emptying in patients with diabetes. It is unknown if better glycemic control increases risks of hypoglycemia or improves hemoglobin A1c levels and gastrointestinal symptoms in diabetic gastroparesis. This study investigated the safety and potential efficacy of continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring (CGM) in poorly controlled diabetes with gastroparesis. Forty-five type 1 or 2 patients with diabetes and gastroparesis and hemoglobin A1c >8% from the NIDDK Gastroparesis Consortium enrolled in a 24 week open-label pilot prospective study of CSII plus CGM...
2018: PloS One
https://www.readbyqxmd.com/read/29651805/editorial-comment-to-non-invasive-assessment-of-kidney-allograft-fibrosis-with-shear-wave-elastography-a-radiological-pathological-correlation-analysis
#3
Ivana Mikolasevic, Tomislav Bokun, Tajana Filipec-Kanizaj
No abstract text is available yet for this article.
April 12, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29651317/risk-of-potential-exposure-incident-in-non-healthcare-workers-in-contact-with-infectious-and-municipal-waste
#4
Sanja Kanisek, Rudika Gmajnić, Ivana Barać
Introduction: The proper classification of sharp and infectious waste in situ by the healthcare workers is an important measure of prevention of sharps and other exposure incidents in non-healthcare workers, who handle such waste. The aim was to examine the practice of classifying sharp and infectious waste in family and dental practices. Methods: An analysis of 50 bags of infectious and 50 bags of municipal waste from five family and five dental practices for five days in October 2016 at the Health centre Osijek...
June 2018: Zdravstveno Varstvo
https://www.readbyqxmd.com/read/29650797/response-complex-issue-of-lipoprotein-functions-in-rheumatoid-arthritis
#5
Nicoletta Ronda, Ivana Hollan
No abstract text is available yet for this article.
May 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29650561/meta-analysis-of-airway-epithelia-gene-expression-in-asthma
#6
Yi-Hsuan Tsai, Joel S Parker, Ivana V Yang, Samir N P Kelada
Differential gene expression in the airway epithelium of asthmatics vs. controls has been reported in several studies. However, there is no consensus on which genes are reproducibly affected in asthma. We sought to identify a consensus list of differentially expressed genes (DEGs) using a meta-analysis approach.We identified eight studies with data that met defined inclusion criteria. In total, these studies were comprised of 355 cases and 193 controls and involved sampling of either bronchial or nasal epithelium...
April 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29649132/effect-of-climate-and-land-use-on-the-spatio-temporal-variability-of-tick-borne-bacteria-in-europe
#7
Roberto Rosà, Veronica Andreo, Valentina Tagliapietra, Ivana Baráková, Daniele Arnoldi, Heidi Christine Hauffe, Mattia Manica, Fausta Rosso, Lucia Blaňarová, Martin Bona, Marketa Derdáková, Zuzana Hamšíková, Maria Kazimírová, Jasna Kraljik, Elena Kocianová, Lenka Mahríková, Lenka Minichová, Ladislav Mošanský, Mirko Slovák, Michal Stanko, Eva Špitalská, Els Ducheyne, Markus Neteler, Zdenek Hubálek, Ivo Rudolf, Kristyna Venclikova, Cornelia Silaghi, Evelyn Overzier, Robert Farkas, Gábor Földvári, Sándor Hornok, Nóra Takács, Annapaola Rizzoli
The incidence of tick-borne diseases caused by Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Rickettsia spp. has been rising in Europe in recent decades. Early pre-assessment of acarological hazard still represents a complex challenge. The aim of this study was to model Ixodes ricinus questing nymph density and its infection rate with B. burgdorferi s.l., A. phagocytophilum and Rickettsia spp. in five European countries (Italy, Germany, Czech Republic, Slovakia, Hungary) in various land cover types differing in use and anthropisation (agricultural, urban and natural) with climatic and environmental factors (Normalized Difference Vegetation Index (NDVI), Normalized Difference Water Index (NDWI), Land Surface Temperature (LST) and precipitation)...
April 12, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29644726/homogeneous-palladium-catalyzed-transfer-hydrogenolysis-of-benzylic-alcohols-using-formic-acid-as-reductant
#8
Benjamin Ciszek, Ivana Fleischer
Herein we report the first homogeneous palladium-based transfer hydrogenolysis of benzylic alcohols using an in situ formed palladium-phosphine complex and formic acid as reducing agent. The reaction requires a catalyst loading as low as only 1 mol% of palladium and just a slight excess of reductant to obtain the deoxygenated alkylarenes in good to excellent yields. Besides demonstrating the broad applicability for primary, secondary and tertiary benzylic alcohols, a reaction intermediate could be identified...
April 12, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29644530/a-posttraumatic-pseudoaneurysm-of-the-left-radial-artery-as-a-result-of-a-stab-wound-in-an-8-year-old-girl
#9
Goran Djuricic, Zorica Milosevic, Tijana Radovic, Ivana Dasic, Djordje Alempijevic, Jelena Sopta
Pseudoaneurysms arise from a disruption of arterial wall continuity and are most commonly related to a penetrating trauma, an arterial wall inflammation or iatrogenic causes. They differ from real aneurysms due to a lack of one or more layers of the arterial wall. The frequency of peripheral artery pseudoaneurysms in the upper extremities is less than in the lower extremities and its most common cause is a gunshot or a stab wound. The risk of a rupture is higher than in true aneurysms due to a lack of wall layers, therefore requiring surgical treatment in most cases...
April 11, 2018: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29643976/autophagy-modulation-in-cancer-current-knowledge-on-action-and-therapy
#10
REVIEW
Mija Marinković, Matilda Šprung, Maja Buljubašić, Ivana Novak
In the last two decades, accumulating evidence pointed to the importance of autophagy in various human diseases. As an essential evolutionary catabolic process of cytoplasmatic component digestion, it is generally believed that modulating autophagic activity, through targeting specific regulatory actors in the core autophagy machinery, may impact disease processes. Both autophagy upregulation and downregulation have been found in cancers, suggesting its dual oncogenic and tumor suppressor properties during malignant transformation...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29642541/influence-of-dietary-supplementation-of-propolis-and-bee-pollen-on-liver-pathology-in-broiler-chickens
#11
Ivana Klaric, Mirela Pavic, Ivan Miskulin, Valerija Blazicevic, Albina Dumic, Maja Miskulin
One of the major problems in intensive breeding of chickens is liver damage. The objective of this study was to determine the influence of dietary supplementation with propolis and bee pollen on liver pathology in broiler chickens. The study was conducted on 200 Ross 308 chickens equally distributed by sex that were divided into five groups. Throughout the whole study, the control group of chickens was fed with a basal diet, while the experimental groups of chickens were fed with the same diet further supplemented with propolis and bee pollen, each supplement given separately or in combination in a certain proportion...
April 9, 2018: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/29630078/applications-of-zeolites-in-biotechnology-and-medicine-a-review
#12
REVIEW
Lucie Bacakova, Marta Vandrovcova, Ivana Kopova, Ivan Jirka
Zeolites are microporous tectosilicates of natural or synthetic origin, which have been extensively used in various technological applications, e.g. as catalysts and as molecular sieves, for separating and sorting various molecules, for water and air purification, including removal of radioactive contaminants, for harvesting waste heat and solar heat energy, for adsorption refrigeration, as detergents, etc. These applications of zeolites were typically related with their porous character, their high adsorption capacity, and their ion exchange properties...
April 9, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29629199/enhanced-recovery-pathways-in-thoracic-surgery-from-italian-vats-group-nursing-care-program
#13
REVIEW
Nicoletta Pia Ardò, Domenico Loizzi, Silvana Panariti, Ivana Piccinin, Francesco Sollitto
Enhanced recovery after surgery (ERAS) is an interprofessional program that can lead to hastened patient recovery and reduced time in hospital. Nursing staff play a key role in the implementation of enhanced recovery protocols. This issue focalizes the role of nurses in ERAS program for patients submitted to Thoracic Surgery, in particular for cases of major lung resection performed by a minimally invasive surgical approach (VATS, video assisted thoracic surgery).
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29628757/the-effects-of-presenting-oncologic-information-in-terms-of-opposites-in-a-medical-context
#14
Roberto Burro, Ugo Savardi, Maria Antonietta Annunziata, Paolo De Paoli, Ivana Bianchi
Background: An extensive body of literature has demonstrated that many patients who have been asked to participate in clinical trials do not fully understand the informed consent forms. A parallel independent study has demonstrated that opposites have a special status in human cognitive organization: they are common to all-natural languages and are intuitively and naturally understood and learnt. Purpose: The study investigates whether, and how, the use of opposites impacts on doctor-patient communication: does using the terms "small-large" to describe a nodule (ie, bipolar communication) rather than speaking in terms of centimeters (ie, unipolar communication) affect a patient's understanding of the situation? And is it better to speak of "common-rare" side effects (ie, bipolar communication) instead of the number of people who have suffered from particular side effects (ie, unipolar communication)? Methods: Two questionnaires were created and used, one presenting the information in terms of opposites (ie, bipolar communication) and another using unipolar communication...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29625885/prognostic-value-of-transthoracic-doppler-echocardiography-coronary-flow-velocity-reserve-in-patients-with-nonculprit-stenosis-of-intermediate-severity-early-after-primary-percutaneous-coronary-intervention
#15
Milorad Tesic, Ana Djordjevic-Dikic, Vojislav Giga, Jelena Stepanovic, Milan Dobric, Ivana Jovanovic, Marija Petrovic, Zlatko Mehmedbegovic, Dejan Milasinovic, Vladimir Dedovic, Milorad Zivkovic, Stefan Juricic, Dejan Orlic, Sinisa Stojkovic, Vladan Vukcevic, Goran Stankovic, Milan Nedeljkovic, Miodrag Ostojic, Branko Beleslin
BACKGROUND: Treatment of nonculprit coronary stenosis during primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction may be beneficial, but the mode and timing of the intervention are still controversial. The aim of this study was to examine the significance and prognostic value of preserved coronary flow velocity reserve (CFVR) in patients with nonculprit intermediate stenosis early after primary percutaneous coronary intervention. METHODS: Two hundred thirty patients with remaining intermediate (50%-70%) stenosis of non-infarct-related arteries, in whom CFVR was performed within 7 days after primary percutaneous coronary intervention, were prospectively enrolled...
April 3, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29625781/human-exposure-to-trace-elements-via-consumption-of-mussels-mytilus-galloprovincialis-from-boka-kotorska-bay-montenegro
#16
Ana Perošević, Danijela Joksimović, Dijana Đurović, Ivana Milašević, Milena Radomirović, Slavka Stanković
In order to assess human health risks via consumption of potentially toxic mussels, the concentrations of Al, Ba, Cd, Co, Cr, Cu, Fe, Li, Mn, Ni, Pb, Sr, Zn and Hg were studied in Mytilus galloprovincialis collected from the coastal area of Montenegro. By two approaches for the human health risk assessment (HHRA), considering oral reference doses by the United States Environmental Protection Agency (US EPA) and provisional tolerable intakes by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), it has been revealed that despite the fact that trace element levels do not exceed the defined limits for mussels, they can be limiting factors for the mussel consumption...
March 28, 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29625478/genetic-risk-factors-for-radiation-vasculopathy
#17
Thanos D Papakostas, Margaux A Morrison, Anne Marie Lane, Caroline Awh, Margaret M DeAngelis, Evangelos S Gragoudas, Ivana K Kim
Purpose: The purpose of this study was to perform a genome-wide scan for polymorphisms associated with risk of vision loss from radiation complications in patients treated with proton beam irradiation for choroidal melanoma. Methods: We identified a cohort of 126 patients at high risk of radiation complications due to tumor location within 2 disc diameters of the optic nerve and/or fovea who provided a blood sample to the Massachusetts Eye and Ear Uveal Melanoma Repository...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29625027/bi-allelic-mutations-in-klhl7-cause-a-crisponi-ciss1-like-phenotype-associated-with-early-onset-retinitis-pigmentosa
#18
Andrea Angius, Paolo Uva, Insa Buers, Manuela Oppo, Alessandro Puddu, Stefano Onano, Ivana Persico, Angela Loi, Loredana Marcia, Wolfgang Höhne, Gianmauro Cuccuru, Giorgio Fotia, Manila Deiana, Mara Marongiu, Hatice Tuba Atalay, Sibel Inan, Osama El Assy, Leo M E Smit, Ilyas Okur, Koray Boduroglu, Gülen Eda Utine, Esra Kılıç, Giuseppe Zampino, Giangiorgio Crisponi, Laura Crisponi, Frank Rutsch
No abstract text is available yet for this article.
April 5, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29624845/neuroprotective-potential-and-chemical-profile-of-alternatively-cultivated-ganoderma-lucidum-basidiocarps
#19
Jasmina Lj Ćilerdžić, Ivana V Sofrenić, Vele V Tešević, Ilija D Brčeski, Sonja N Duletić-Laušević, Jelena B Vukojević, Mirjana M Stajić
Various neurodegenerative diseases are the main challenges to the modern medicine and there is a great need for novel, natural, neuroprotective agents. Ganoderma lucidum is a well-known medicinal mushroom which health benefits have been confirmed by numerous studies. As demand for its basidiocarps is increased and traditional cultivation on hardwoods is not environmentally-friendly and economically-justified, finding of alternative substrates is necessary. The aim of the study was to assess the effect of alternative cultivation substrates on the chemical profile of G...
April 6, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29624713/clinical-and-imaging-hallmarks-of-the-myh7-related-myopathy-with-severe-axial-involvement
#20
Ivana Dabaj, Robert Y Carlier, David Gómez-Andrés, Osório Abath Neto, Enrico Bertini, Adele D'Amico, Fabiana Fattori, Yann Péréon, Claudia Castiglioni, Eliana Rodillo, Michela Catteruccia, Júlio Brandão Guimarães, Acary Souza Bulle Oliveira, Umbertina Conti Reed, Lilia Mesrob, Doris Lechner, Anne Boland, Jean-François Deleuze, Edoardo Malfatti, Carsten Bonnemann, Jocelyn Laporte, Norma Romero, Adrien Felter, Susana Quijano-Roy, Cristiane Araújo Martins Moreno, Edmar Zanoteli
INTRODUCTION: MYH7 gene mutations are related to a heterogeneous group of skeletal and cardiac myopathies. METHODS: We evaluated clinical and muscle magnetic resonance imaging changes in patients with mutations in the rod domain of MYH7 including one with mosaicism and three with novel missense mutations. RESULTS: Patients presented in childhood with a distal and axial phenotype. Biopsy findings were variable. Half of the cases displaying some type of core pathology, including minicores and eccentric cores...
April 6, 2018: Muscle & Nerve
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