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JOURNAL ARTICLE
Edgar M Pera, Josefine Nilsson-De Moura, Yuriy Pomeshchik, Laurent Roybon, Ivana Milas
We previously showed that SerpinE2 and the serine protease HtrA1 modulate fibroblast growth factor (FGF) signaling in germ layer specification and head-to-tail development of Xenopus embryos. Here, we present an extracellular proteolytic mechanism involving this serpin-protease system in the developing neural crest (NC). Knockdown of SerpinE2 by injected antisense morpholino oligonucleotides did not affect the specification of NC progenitors but instead inhibited the migration of NC cells, causing defects in dorsal fin, melanocyte, and craniofacial cartilage formation...
April 18, 2024: ELife
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JOURNAL ARTICLE
Tamires Dos Santos Vieira, Flávia Vitorino Freitas, Luiz Cláudio Barreto Silva Neto, Aline Ribeiro Borçoi, Suzanny Oliveira Mendes, Amanda Sgrancio Olinda, Ivana Alece Arantes Moreno, Bárbara Risse Quaioto, Marcele Lorentz Mattos de Souza, Wagner Miranda Barbosa, Juliana Krüger Arpini, Bruna Pereira Sorroche, Julia de Assis Pinheiro, Anderson Barros Archanjo, Joaquim Gasparini Dos Santos, Lidia Maria Rebolho Batista Arantes, Daniela Rodrigues de Oliveira, Adriana Madeira Alvares da Silva
BACKGROUND: Dietary composition can modify gene expression, favoring the development of chronic diseases via epigenetic mechanisms. OBJECTIVE: Our study aimed to investigate the relationship between dietary patterns and NR3C1 gene methylation in users of the Brazilian Public Unified Health System (SUS). METHODS: We recruited 250 adult volunteers and evaluated their socioeconomic status, psychosocial characteristics, lifestyle, and anthropometrics...
2024: Frontiers in Nutrition
#3
JOURNAL ARTICLE
Ivana Keenan, Laura Cullen, Gabrielle Hogan, Noirin O'Herlihy, Ciara McCarthy, Claire Collins
BACKGROUND: Over the last two decades, many countries have reported an increased percentage of females in the general practice workforce. Considering the importance of general practice workforce planning, it is necessary to investigate the current working patterns of female GPs. AIM: To describe the female GP workforce in Ireland and to investigate factors that may impact their long-term commitment to general practice. DESIGN & SETTING: Descriptive, cross-sectional study conducted with female GPs in Ireland...
April 17, 2024: BJGP Open
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JOURNAL ARTICLE
Dunja Kokai, Jelena Markovic Filipovic, Marija Opacic, Ivana Ivelja, Vojislav Banjac, Bojana Stanic, Nebojsa Andric
The effect of endothelial cells' exposure to dibutyl phthalate (DBP) on monocyte adhesion is largely unknown. We evaluated monocyte adhesion to DBP-exposed endothelial cells by combining three approaches: short-term exposure (24 h) of EA.hy926 cells to 10-6 , 10-5 , and 10-4 M DBP, long-term exposure (12 weeks) of EA.hy926 cells to 10-9 , 10-8 , and 10-7 M DBP, and exposure of rats (28 and 90 days) to 100, 500, and 5000 mg DBP/kg food. Monocyte adhesion to human EA.hy926 and rat aortic endothelial cells, expression of selected cellular adhesion molecules and chemokines, and the involvement of extracellular signal-regulated kinase 1/2 (ERK1/2) were analyzed...
April 15, 2024: Food and Chemical Toxicology
#5
EDITORIAL
Ivana Didirková
No abstract text is available yet for this article.
April 2, 2024: Clinical Linguistics & Phonetics
#6
JOURNAL ARTICLE
Leo Meriranta, Selma Sorri, Kanutte Huse, Xiaonan Liu, Ivana Spasevska, Sadia Zafar, Iftekhar Chowdhury, Olli Dufva, Eerika Sahlberg, Luka Tandaric, Marja-Liisa Karjalainen-Lindsberg, Marko Hyytiainen, Markku Varjosalo, June H Myklebust, Sirpa Leppa
Pathomechanisms that activate oncogenic B-cell receptor (BCR) signaling in diffuse large B-cell lymphoma (DLBCL), are largely unknown. Kelch-like family member 6 (KLHL6) encoding a substrate-adapter for Cullin-3-RING E3 ubiquitin-ligase (CRL) with poorly established targets is recurrently mutated in DLBCL. By applying high-throughput protein interactome screens and functional characterization, we discovered that KLHL6 regulates BCR by targeting its signaling subunits CD79A and CD79B. Loss of physiological KLHL6 expression pattern was frequent among the MCD/C5-like activated B-cell DLBCLs and was associated with higher CD79B levels and dismal outcome...
April 17, 2024: Blood cancer discovery
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JOURNAL ARTICLE
Milica Z Stevanović, Sofija S Bekić, Edward T Petri, Andjelka S Ćelić, Dimitar S Jakimov, Marija N Sakač, Ivana Z Kuzminac
Aim: The aim of this study was the synthesis of steroid compounds with heterocyclic rings and good anticancer properties. Materials & methods: The synthesis, in silico and in vitro anticancer testing of novel pyridin-2-yl estra-1,3,5(10)-triene derivatives was performed. Results: All synthesized compounds have shown promising results for, antiproliferative activity, relative binding affinities for the ligand binding domains of estrogen receptors α, β and androgen receptor, aromatase binding potential, and inhibition of AKR1C3 enzyme...
April 17, 2024: Future Medicinal Chemistry
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JOURNAL ARTICLE
Alina Kalyniukova, Alica Várfalvyová, Justyna Płotka-Wasylka, Tomasz Majchrzak, Patrycja Makoś-Chełstowska, Ivana Tomášková, Vítězslava Pešková, Filip Pastierovič, Anna Jirošová, Vasil Andruch
Polyphenolic compounds play an essential role in plant growth, reproduction, and defense mechanisms against pathogens and environmental stresses. Extracting these compounds is the initial step in assessing phytochemical changes, where the choice of extraction method significantly influences the extracted analytes. However, due to environmental factors, analyzing numerous samples is necessary for statistically significant results, often leading to the use of harmful organic solvents for extraction. Therefore, in this study, a novel DES-based shaking-assisted extraction procedure for the separation of polyphenolic compounds from plant samples followed by LC-ESI-QTOF-MS analysis was developed...
2024: Frontiers in Chemistry
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JOURNAL ARTICLE
Sherman Lin, Christopher Tran, Ela Bandari, Tommaso Romagnoli, Yueyang Li, Michael Chu, Abinaya S Amirthakatesan, Adam Dallmann, Andrii Kostiukov, Angel Panizo, Anjelica Hodgson, Anna R Laury, Antonio Polonia, Ashley E Stueck, Aswathy A Menon, Aurélien Morini, Birsen Özamrak, Caroline Cooper, Celestine Marie G Trinidad, Christian Eisenlöffel, Dauda E Suleiman, David Suster, David A Dorward, Eman A Aljufairi, Fiona Maclean, Gulen Gul, Irene Sansano, Irma E Erana-Rojas, Isidro Machado, Ivana Kholova, Jayanthi Karunanithi, Jean-Baptiste Gibier, Jefree J Schulte, Joshua J X Li, Jyoti R Kini, Katrina Collins, Laurence A Galea, Louis Muller, Luca Cima, Luiz M Nova-Camacho, Marcus Dabner, Matthew J Muscara, Matthew G Hanna, Mehdi Agoumi, Nicholas J P Wiebe, Nicola K Oswald, Nusrat Zahra, Olaleke O Folaranmi, Oleksandr Kravtsov, Orhan Semerci, Namrata N Patil, Preethi Muthusamy Sundar, Prem Charles, Priyadarshini Kumaraswamy Rajeswaran, Qi Zhang, Rachael van der Griend, Raghavendra Pillappa, Raul Perret, Raul S Gonzalez, Robyn C Reed, Sachin Patil, Xiaoyin Sara Jiang, Sumaira Qayoom, Susan Prendeville, Swikrity U Baskota, Thanh-Truc Tran, Thar-Htet San, Tiia-Maria Kukkonen, Timothy J Kendall, Toros Taskin, Tristan Rutland, Varsha Manucha, Vincent Cockenpot, Yale Rosen, Yessica P Rodriguez-Velandia, Zehra Ordulu, Matthew J Cecchini
Introduction. The identification of mitotic figures is essential for the diagnosis, grading, and classification of various different tumors. Despite its importance, there is a paucity of literature reporting the consistency in interpreting mitotic figures among pathologists. This study leverages publicly accessible datasets and social media to recruit an international group of pathologists to score an image database of more than 1000 mitotic figures collectively. Materials and Methods. Pathologists were instructed to randomly select a digital slide from The Cancer Genome Atlas (TCGA) datasets and annotate 10-20 mitotic figures within a 2 mm2 area...
April 16, 2024: International Journal of Surgical Pathology
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JOURNAL ARTICLE
Ivana Nemeckova, Samira Eissazadeh, Jana Urbankova Rathouska, Jan Silhavy, Hana Malinska, Michal Pravenec, Petr Nachtigal
BACKGROUND: C-reactive protein (CRP) is an acute inflammatory protein detected in obese patients with metabolic syndrome. Moreover, increased CRP levels have been linked with atherosclerotic disease, congestive heart failure, and ischemic heart disease, suggesting that it is not only a biomarker but also plays an active role in the pathophysiology of cardiovascular diseases. Since endothelial dysfunction plays an essential role in various cardiovascular pathologies and is characterized by increased expression of cell adhesion molecules and inflammatory markers, we aimed to detect specific markers of endothelial dysfunction, inflammation, and oxidative stress in spontaneously hypertensive rats (SHR) expressing human CRP...
April 16, 2024: BMC Cardiovascular Disorders
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JOURNAL ARTICLE
Jacek Wachowiak, Jacques-Emmanuel Galimard, Arnaud Dalissier, Rawad Rihani, Hawazen AlSaedi, Robert F Wynn, Jean-Hugues Dalle, Régis Peffault de Latour, Petr Sedlacek, Adriana Balduzzi, Thomas Schroeder, Ivana Bodova, Marta Gonzalez Vicent, Bernd Gruhn, Rose-Marie Hamladji, Gergely Krivan, Katharine Patrick, Agnieszka Sobkowiak-Sobierajska, Polina Stepensky, Ali Unal, Persis Amrolia, Antonio Perez Martinez, Fanny Rialland, Mahmoud Aljurf, Antonella Isgro, Amos Toren, Marc Bierings, Selim Corbacioglu, Krzysztof Kałwak
This retrospective study evaluated 35 children (median age 5.2 years; range 0.4-18) with myelofibrosis (MF), including 33 with primary myelofibrosis and 2 with secondary myelofibrosis transplanted from matched sibling donor (MSD) (n = 17) or non-MSD (n = 18) between 2000 and 2022. Conditioning was usually chemotherapy-based (n = 33) and myeloablative (n = 32). Fifteen patients received bone marrow (BM), 14 haematopoietic cells (HC) from peripheral blood (PB), and 6 from cord blood (CB)...
April 16, 2024: Bone Marrow Transplantation
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REVIEW
Dennis Schmiege, Timo Haselhoff, Alexander Thomas, Ivana Kraiselburd, Folker Meyer, Susanne Moebus
Wastewater analysis can serve as a source of public health information. In recent years, wastewater-based epidemiology (WBE) has emerged and proven useful for the detection of infectious diseases. However, insights from the wastewater treatment plant do not allow for the small-scale differentiation within the sewer system that is needed to analyze the target population under study in more detail. Small-scale WBE offers several advantages, but there has been no systematic overview of its application. The aim of this scoping review is to provide a comprehensive overview of the current state of knowledge on small-scale WBE for infectious diseases, including methodological considerations for its application...
April 15, 2024: International Journal of Hygiene and Environmental Health
#13
JOURNAL ARTICLE
Stefano Passanisi, Giuseppina Salzano, Bruno Bombaci, Nicola Minuto, Marta Bassi, Riccardo Bonfanti, Francesco Scialabba, Enza Mozzillo, Francesca Di Candia, Sara Monti, Vanna Graziani, Claudio Maffeis, Claudia Anita Piona, Claudia Arnaldi, Davide Tosini, Barbara Felappi, Rosalia Roppolo, Angela Zanfardino, Maurizio Delvecchio, Donatella Lo Presti, Elena Calzi, Carlo Ripoli, Roberto Franceschi, Petra Reinstadler, Ivana Rabbone, Giulio Maltoni, Angela Alibrandi, Stefano Zucchini, Marco Marigliano, Fortunato Lombardo
OBJECTIVE: To investigate glucose metrics and identify potential predictors of the achievement of glycemic outcomes in children and adolescents during their first 12 months of MiniMed 780G use. RESEARCH DESIGN AND METHODS: This multicenter, longitudinal, real-world study recruited 368 children and adolescents with type 1 diabetes (T1D) starting SmartGuard technology between June 2020 and June 2022. Ambulatory glucose profile data were collected during a 15-day run-in period (baseline), 2 weeks after automatic mode activation, and every 3 months...
April 16, 2024: Diabetes Care
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JOURNAL ARTICLE
Francesco Michele Ronza, Teresa Letizia Di Gennaro, Felice Gragnano, Enrica Golia, Mariangela Iodice, Giuseppe Posillico, Maria Antonietta Rucco, Ivana Pariggiano, Pasquale Sullo, Paolo Calabrò
No abstract text is available yet for this article.
April 3, 2024: Journal of Cardiovascular Medicine
#15
JOURNAL ARTICLE
Nives Matijaković Mlinarić, Katarina Marušić, Antun Lovro Brkić, Marijan Marciuš, Tamara Aleksandrov Fabijanić, Nenad Tomašić, Atiđa Selmani, Eva Roblegg, Damir Kralj, Ivana Stanić, Branka Njegić Džakula, Jasminka Kontrec
Plastic pollution in aquatic ecosystems has become a significant problem especially microplastics which can encapsulate into the skeletons of organisms that produce calcium carbonates, such as foraminifera, molluscs and corals. The encapsulation of microplastics into precipitated aragonite, which in nature builds the coral skeleton, has not yet been studied. It is also not known how the dissolved organic matter, to which microplastics are constantly exposed in aquatic ecosystems, affects the encapsulation of microplastics into aragonite and how such microplastics affect the mechanical properties of aragonite...
April 16, 2024: Environmental Science. Processes & Impacts
#16
JOURNAL ARTICLE
Iveta Selingerova, Klara Holikova, Tomas Chodur, Ludmila Hynkova, Petr Pospisil, Martin Bulik, Renata Belanova, Kamila Siffelova, Ivana Kolouskova, Marek Slavik, Petr Burkon, Roman Hrstka, Radim Jancalek, Jiri Sana, Pavel Slampa, Tomas Kazda
AIM: Patients with multiple brain metastases (BM) benefit from hippocampal-avoiding whole brain radiotherapy (HA-WBRT), the challenging and less available form of WBRT. This study explores potential of pre-radiotherapy (pre-RT) hippocampal magnetic resonance spectroscopy (MRS) measuring hippocampal neuronal density as an imaging surrogate and predictive tool for assessing neurocognitive functions (NCF). METHODS: 43 BM patients underwent pre-RT hippocampal MRS. N-acetyl aspartate (NAA) concentration, a marker for neuronal density (weighted by creatine (Cr) and choline (Cho) concentrations), and neurocognitive function (NCF) tests (HVLT and BVMT) performed by certified psychologists were evaluated...
April 15, 2024: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
#17
JOURNAL ARTICLE
Marc Ghanem, Camilo Espinosa, Philip Chung, Momsen Reincke, Natasha Harrison, Thanaphong Phongpreecha, Sayane Shome, Geetha Saarunya, Eloise Berson, Tomin James, Feng Xie, Chi-Hung Shu, Debapriya Hazra, Samson Mataraso, Yeasul Kim, David Seong, Dipro Chakraborty, Manuel Studer, Lei Xue, Ivana Marić, Alan L Chang, Erico Tjoa, Brice Gaudillière, Vivianne L Tawfik, Sean Mackey, Nima Aghaeepour
BACKGROUND: Anesthesiology plays a crucial role in perioperative care, critical care, and pain management, impacting patient experiences and clinical outcomes. However, our understanding of the anesthesiology research landscape is limited. Accordingly, we initiated a data-driven analysis through topic modeling to uncover research trends, enabling informed decision-making and fostering progress within the field. METHODS: The easyPubMed R package was used to collect 32,300 PubMed abstracts spanning from 2000 to 2022...
April 15, 2024: Heliyon
#18
JOURNAL ARTICLE
Ivana Clark, Phoebe Wallman, Siobhan Gee, David Taylor
No abstract text is available yet for this article.
April 15, 2024: Acta Psychiatrica Scandinavica
#19
JOURNAL ARTICLE
Solomon Ofori, David Kwesi Abebrese, Aleš Klement, Daniel Provazník, Ivana Tomášková, Iveta Růžičková, Jiří Wanner
The study evaluated the impact of treated wastewater on plant growth through the use of hyperspectral and fluorescence-based techniques coupled with classical biomass analyses, and assessed the potential of reusing treated wastewater for irrigation without fertilizer application. Cherry tomato ( Solanum lycopersicum ) and cabbage ( Brassica oleracea L.) were irrigated with tap water (Tap), secondary effluent (SE), and membrane effluent (ME). Maximum quantum yield of photosystem II ( Fv / Fm ) of tomato and cabbage was between 0...
April 2024: Water Science and Technology: a Journal of the International Association on Water Pollution Research
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JOURNAL ARTICLE
Andjela Stekic, Dejan Stevic, Tamara Dokmanovic, Marina Anastasov, Danica Popovic, Jelena Stanojevic, Milica Zeljkovic Jovanovic, Ivana Stevanovic, Nadezda Nedeljkovic, Milorad Dragic
Experimental autoimmune encephalomyelitis (EAE) is widely used animal model of multiple sclerosis (MS). The disease is characterized by demyelination and neurodegeneration triggered by infiltrated autoimmune cells and their interaction with astrocytes and microglia. While neuroinflammation is most common in the spinal cord and brainstem, it is less prevalent in the cerebellum, where it predisposes to rapid disease progression. Because the induction and progression of EAE are tightly regulated by adenosinergic signaling, in the present study we compared the adenosine-producing and -degrading enzymes, ecto-5'-nucleotidase (eN/CD73) and adenosine deaminase (ADA), as well as the expression levels of adenosine receptors A1 R and A2A R subtypes in nearby areas around the fourth cerebral ventricle-the pontine tegmentum, the choroid plexus (CP), and the cerebellum...
April 15, 2024: Molecular Neurobiology
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