keyword
MENU ▼
Read by QxMD icon Read
search

Ivana

keyword
https://www.readbyqxmd.com/read/29035132/hybrid-lipid-polymer-nanoparticles-for-pulmonary-delivery-of-sirna-development-and-fate-upon-in-vitro-deposition-on-the-human-epithelial-airway-barrier
#1
Ivana d'Angelo, Gabriella Costabile, Estelle Durantie, Paola Brocca, Valeria Rondelli, Annapina Russo, Giulia Russo, Agnese Miro, Fabiana Quaglia, Alke Petri-Fink, Barbara Rothen-Rutishauser, Francesca Ungaro
BACKGROUND: Nowadays, the downregulation of genes involved in the pathogenesis of severe lung diseases through local siRNA delivery appears an interesting therapeutic approach. In this study, we propose novel hybrid lipid-polymer nanoparticles (hNPs) consisting of poly(lactic-co-glycolic) acid (PLGA) and dipalmitoyl phosphatidylcholine (DPPC) as siRNA inhalation system. METHODS: A panel of DPPC/PLGA hNPs was prepared by emulsion/solvent diffusion and fully characterized...
October 16, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29033838/the-target-residence-time-of-antihistamines-determines-their-antagonism-of-the-g-protein-coupled-histamine-h1-receptor
#2
Reggie Bosma, Gesa Witt, Lea A I Vaas, Ivana Josimovic, Philip Gribbon, Henry F Vischer, Sheraz Gul, Rob Leurs
The pharmacodynamics of drug-candidates is often optimized by metrics that describe target binding (Kd or Ki value) or target modulation (IC50). However, these metrics are determined at equilibrium conditions, and consequently information regarding the onset and offset of target engagement and modulation is lost. Drug-target residence time is a measure for the lifetime of the drug-target complex, which has recently been receiving considerable interest, as target residence time is shown to have prognostic value for the in vivo efficacy of several drugs...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29033373/evaluating-the-causal-link-between-malaria-infection-and-endemic-burkitt-lymphoma-in-northern-uganda-a-mendelian-randomization-study
#3
Ismail D Legason, Ruth M Pfeiffer, Krizia-Ivana Udquim, Andrew W Bergen, Mateus H Gouveia, Samuel Kirimunda, Isaac Otim, Eric Karlins, Patrick Kerchan, Hadijah Nabalende, Ariunaa Bayanjargal, Benjamin Emmanuel, Paul Kagwa, Ambrose O Talisuna, Kishor Bhatia, Meredith Yeager, Robert J Biggar, Leona W Ayers, Steven J Reynolds, James J Goedert, Martin D Ogwang, Joseph F Fraumeni, Ludmila Prokunina-Olsson, Sam M Mbulaiteye
BACKGROUND: Plasmodium falciparum (Pf) malaria infection is suspected to cause endemic Burkitt Lymphoma (eBL), but the evidence remains unsettled. An inverse relationship between sickle cell trait (SCT) and eBL, which supports that between malaria and eBL, has been reported before, but in small studies with low power. We investigated this hypothesis in children in a population-based study in northern Uganda using Mendelian Randomization. METHODS: Malaria-related polymorphisms (SCT, IL10, IL1A, CD36, SEMA3C, and IFNAR1) were genotyped in 202 eBL cases and 624 controls enrolled during 2010-2015...
October 3, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29033181/pathobiology-of-her-2-positive-small-invasive-t1a-b-breast-cancer-a-wolf-in-sheep-s-clothing
#4
Joško Bezić, Ivana Šamija Projić, Petar Projić, Kristina Meljanac Salopek, Piero Marin Živković, Joško Božić, Snježana Tomić
Small invasive breast cancers (cancers with maximum diameter <1cm, T1a,b) become more prevalent form of breast cancer as a result of the introduction of breast cancer mammographic screening programs. Although associated with an excellent prognosis, T1a,b breast cancers are heterogeneous group of tumors with prognostically unfavorable subset of cases, primarily those with axillary lymph node metastases. To determine if the HER2 overexpression is associated with the prognostically unfavorable traditional clinicopathological features in this group of breast cancers, clinicopathological features (age, tumor size, histological type, histological grade, nodal status, hormone receptor status, proliferation index, lymphovascular invasion, ploidy) of 38 HER2 positive T1a,b cancers were compared with those of the control group consisting of 315 HER2 negative T1a,b cancers...
October 9, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29032752/association-between-apolipoproteins-ai-and-b-and-ultrasound-indicators-of-carotid-atherosclerosis
#5
Zeljko Zivanovic, Ivana Divjak, Mirjana Jovicevic, Tamara Rabi-Zikic, Biljana Radovanovic, Svetlana Ruzicka-Kaloci, Djordje Stevan Popovic, Edita Stokic, Ksenija Gebauer-Bukurov, Katarina Zivanovic-Vujcic, Petar Slankamenac
BACKGROUND: Apolipoproteins A-I and B (apoA-I and apoB) may be better indicators of the risk of cardiovascular and cerebrovascular diseases than conventional risk factors (RFs). The onset of ischemic stroke (IS) may be preceded by the development of atherosclerotic changes in carotid arteries, which can be detected by ultrasound. Only a certain % of patients with IS have an (underlying) carotid etiology. OBJECTIVE: The aim of our study was to determine the association between ultrasound indicators of carotid atherosclerosis and the presence of apolipoproteins and other biomarkers in patients with IS...
October 10, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29030765/cerebrospinal-fluid-analysis-and-the-determination-of-oligoclonal-bands
#6
REVIEW
Matteo Gastaldi, Elisabetta Zardini, Rosaria Leante, Maddalena Ruggieri, Gianna Costa, Eleonora Cocco, Giovanna De Luca, Ivana Cataldo, Tiziana Biagioli, Clara Ballerini, Massimiliano Castellazzi, Enrico Fainardi, Paola Pettini, Mauro Zaffaroni, Debora Giunti, Elisabetta Capello, Gaetano Bernardi, Emilio Ciusani, Claudia Giannotta, Eduardo Nobile-Orazio, Elena Bazzigaluppi, Gabriella Passerini, Roberta Bedin, Patrizia Sola, Rinaldo Brivio, Guido Cavaletti, Arianna Sala, Antonio Bertolotto, Gaetano Desina, Maurizio A Leone, Sara Mariotto, Sergio Ferrari, Andreina Paternoster, Davide Giavarina, Francesco Lolli, Diego Franciotta
This document presents the guidelines for the cerebrospinal fluid (CSF) analysis and the determination of oligoclonal bands (OCBs) as pivotal tests in neuroinflammatory pathologies of the central nervous system. The guidelines have been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses. Essential clinical information on the pathologies in which the CSF analysis is indicated, and, particularly, on those characterized by the presence of OCBs in the intrathecal compartment, indications and limits of CSF analysis and OCB determination, instructions for result interpretation, and agreed laboratory protocols (Appendix) are reported for the communicative community of neurologists and clinical pathologists...
October 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29028551/exploring-the-safety-in-numbers-effect-for-vulnerable-road-users-on-a-macroscopic-scale
#7
Ivana Tasic, Rune Elvik, Simon Brewer
A "Safety in Numbers" effect for a certain group of road users is present if the number of crashes increases at a lower rate than the number of road users. The existence of this effect has been invoked to justify investments in multimodal transportation improvements in order to create more sustainable urban transportation systems by encouraging walking, biking, and transit ridership. The goal of this paper is to explore safety in numbers effect for cyclists and pedestrians in areas with different levels of access to multimodal infrastructure...
October 10, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29027794/artificial-metalloproteins-for-binding-and-stabilization-of-a-semiquinone-radical
#8
Nathalie Ségaud, Ivana Drienovská, Juan Chen, Wesley R Browne, Gerard Roelfes
The interaction of a number of first-row transition-metal ions with a 2,2'-bipyridyl alanine (bpyA) unit incorporated into the lactococcal multidrug resistance regulator (LmrR) scaffold is reported. The composition of the active site is shown to influence binding affinities. In the case of Fe(II), we demonstrate the need of additional ligating residues, in particular those containing carboxylate groups, in the vicinity of the binding site. Moreover, stabilization of di-tert-butylsemiquinone radical (DTB-SQ) in water was achieved by binding to the designed metalloproteins, which resulted in the radical being shielded from the aqueous environment...
October 13, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29026629/a-case-of-exophiala-dermatitidis-infection-in-a-child-after-allogeneic-stem-cell-transplantation-case-report-and-literature-review-of-paediatric-cases
#9
Dominika Tanuskova, Julia Horakova, Darina Buzassyova, Miroslava Poczova, Ivana Bodova, Peter Svec, Alica Chocholova, Jaroslava Adamcakova, Tomas Sykora, Miroslava Pozdechova, Lucia Geczova, Alexandra Kolenova
Introduction.Exophiala dermatitidisis a relatively common environmental black yeast with worldwide distribution and is a rare cause of fungal infection, mostly in patients with certain predisposing factors. Due to the rarity of the infection, little is known about the specific predisposing factors, way of infection or treatment. Case presentation. Here, we report what is to our knowledge the first case of E. dermatitidis infection in a child after allogeneic stem cell transplantation. We also review all paediatric cases reported in the literature since 1993...
June 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29026447/epigenome-alterations-in-aortic-valve-stenosis-and-its-related-left-ventricular-hypertrophy
#10
REVIEW
Igor Gošev, Martina Zeljko, Željko Đurić, Ivana Nikolić, Milorad Gošev, Sanja Ivčević, Dino Bešić, Zoran Legčević, Frane Paić
Aortic valve stenosis is the most common cardiac valve disease, and with current trends in the population demographics, its prevalence is likely to rise, thus posing a major health and economic burden facing the worldwide societies. Over the past decade, it has become more than clear that our traditional genetic views do not sufficiently explain the well-known link between AS, proatherogenic risk factors, flow-induced mechanical forces, and disease-prone environmental influences. Recent breakthroughs in the field of epigenetics offer us a new perspective on gene regulation, which has broadened our perspective on etiology of aortic stenosis and other aortic valve diseases...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/29025028/cohort-profile-pregnancy-and-childhood-epigenetics-pace-consortium
#11
Janine F Felix, Bonnie R Joubert, Andrea A Baccarelli, Gemma C Sharp, Catarina Almqvist, Isabella Annesi-Maesano, Hasan Arshad, Nour Baïz, Marian J Bakermans-Kranenburg, Kelly M Bakulski, Elisabeth B Binder, Luigi Bouchard, Carrie V Breton, Bert Brunekreef, Kelly J Brunst, Esteban G Burchard, Mariona Bustamante, Leda Chatzi, Monica Cheng Munthe-Kaas, Eva Corpeleijn, Darina Czamara, Dana Dabelea, George Davey Smith, Patrick De Boever, Liesbeth Duijts, Terence Dwyer, Celeste Eng, Brenda Eskenazi, Todd M Everson, Fahimeh Falahi, M Daniele Fallin, Sara Farchi, Mariana F Fernandez, Lu Gao, Tom R Gaunt, Akram Ghantous, Matthew W Gillman, Semira Gonseth, Veit Grote, Olena Gruzieva, Siri E Håberg, Zdenko Herceg, Marie-France Hivert, Nina Holland, John W Holloway, Cathrine Hoyo, Donglei Hu, Rae-Chi Huang, Karen Huen, Marjo-Riitta Järvelin, Dereje D Jima, Allan C Just, Margaret R Karagas, Robert Karlsson, Wilfried Karmaus, Katerina J Kechris, Juha Kere, Manolis Kogevinas, Berthold Koletzko, Gerard H Koppelman, Leanne K Küpers, Christine Ladd-Acosta, Jari Lahti, Nathalie Lambrechts, Sabine A S Langie, Rolv T Lie, Andrew H Liu, Maria C Magnus, Per Magnus, Rachel L Maguire, Carmen J Marsit, Wendy McArdle, Erik Melén, Phillip Melton, Susan K Murphy, Tim S Nawrot, Lorenza Nisticò, Ellen A Nohr, Björn Nordlund, Wenche Nystad, Sam S Oh, Emily Oken, Christian M Page, Patrice Perron, Göran Pershagen, Costanza Pizzi, Michelle Plusquin, Katri Raikkonen, Sarah E Reese, Eva Reischl, Lorenzo Richiardi, Susan Ring, Ritu P Roy, Peter Rzehak, Greet Schoeters, David A Schwartz, Sylvain Sebert, Harold Snieder, Thorkild I A Sørensen, Anne P Starling, Jordi Sunyer, Jack A Taylor, Henning Tiemeier, Vilhelmina Ullemar, Marina Vafeiadi, Marinus H Van Ijzendoorn, Judith M Vonk, Annette Vriens, Martine Vrijheid, Pei Wang, Joseph L Wiemels, Allen J Wilcox, Rosalind J Wright, Cheng-Jian Xu, Zongli Xu, Ivana V Yang, Paul Yousefi, Hongmei Zhang, Weiming Zhang, Shanshan Zhao, Golareh Agha, Caroline L Relton, Vincent W V Jaddoe, Stephanie J London
No abstract text is available yet for this article.
September 13, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29025017/cohort-profile-the-lymphoma-specialized-program-of-research-excellence-spore-molecular-epidemiology-resource-mer-cohort-study
#12
James R Cerhan, Brian K Link, Thomas M Habermann, Matthew J Maurer, Andrew L Feldman, Sergei I Syrbu, Carrie A Thompson, Umar Farooq, Anne J Novak, Susan L Slager, Cristine Allmer, Julianne J Lunde, William R Macon, David J Inwards, Patrick B Johnston, Ivana N M Micallef, Grzegorz S Nowakowski, Stephen M Ansell, Neil E Kay, George J Weiner, Thomas E Witzig
No abstract text is available yet for this article.
August 18, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29022262/myocardial-infarction-and-exercise-training-evidence-from-basic-science
#13
Ivana C Moraes-Silva, Bruno Rodrigues, Hélio J Coelho-Junior, Daniele Jardim Feriani, Maria-Claudia Irigoyen
In 2016, cardiovascular disease remains the first cause of mortality worldwide [1]. Coronary artery disease, which is the most important precursor of myocardial infarction (MI), is the main component of total cardiovascular mortality, being responsible for approximately seven million of deaths [1]. In approximately 20% of infarcted patients, MI is recurrent in the first year after the event [2]. Moreover, among cardiovascular disease, coronary artery disease accounts for the most increased index of life years lost due to morbidity and/or mortality [1]...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29021774/corrigendum-marital-satisfaction-sex-age-marriage-duration-religion-number-of-children-economic-status-education-and-collectivistic-values-data-from-33-countries
#14
Piotr Sorokowski, Ashley K Randall, Agata Groyecka, Tomasz Frackowiak, Katarzyna Cantarero, Peter Hilpert, Khodabakhsh Ahmadi, Ahmad M Alghraibeh, Richmond Aryeetey, Anna Bertoni, Karim Bettache, Marta Błazejewska, Guy Bodenmann, Tiago S Bortolini, Carla Bosc, Marina Butovskaya, Felipe N Castro, Hakan Cetinkaya, Diana Cunha, Daniel David, Oana A David, Fahd A Dileym, Alejandra C Domínguez Espinosa, Silvia Donato, Daria Dronova, Seda Dural, Maryanne Fisher, Aslihan Hamamcıoğlu Akkaya, Takeshi Hamamura, Karolina Hansen, Wallisen T Hattori, Ivana Hromatko, Evrim Gülbetekin, Raffaella Iafrate, Bawo James, Feng Jiang, Charles O Kimamo, Firat Koç, Anna Krasnodębska, Amos Laar, Fívia A Lopes, Rocio Martinez, Norbert Meskó, Natalya Molodovskaya, Khadijeh Moradi Qezeli, Zahrasadat Motahari, Jean C Natividade, Joseph Ntayi, Oluyinka Ojedokun, Mohd S B Omar-Fauzee, Ike E Onyishi, Barış Özener, Anna Paluszak, Alda Portugal, Anu Realo, Ana P Relvas, Muhammad Rizwan, Agnieszka L Sabiniewicz, Svjetlana Salkicević, Ivan Sarmány-Schuller, Eftychia Stamkou, Stanislava Stoyanova, Denisa Šukolová, Nina Sutresna, Meri Tadinac, Andero Teras, Edna L T Ponciano, Ritu Tripathi, Nachiketa Tripathi, Mamta Tripathi, Maria E Yamamoto, Gyesook Yoo, Agnieszka Sorokowska
[This corrects the article on p. 1199 in vol. 8, PMID: 28785230.].
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29017478/effectiveness-of-pulmonary-rehabilitation-in-patients-with-interstitial-lung-disease-of-different-etiology-a-multicenter-prospective-study
#15
Roberto Tonelli, Elisabetta Cocconcelli, Barbara Lanini, Isabella Romagnoli, Fabio Florini, Ivana Castaniere, Dario Andrisani, Stefania Cerri, Fabrizio Luppi, Riccardo Fantini, Alessandro Marchioni, Bianca Beghè, Francesco Gigliotti, Enrico M Clini
BACKGROUND: Recent evidences show that Pulmonary Rehabilitation (PR) is effective in patients with Interstitial Lung Disease (ILD). It is still unclear whether disease severity and/or etiology might impact on the reported benefits. We designed this prospective study 1) to confirm the efficacy of rehabilitation in a population of patients with ILDs and 2) to investigate whether baseline exercise capacity, disease severity or ILD etiology might affect outcomes. METHODS: Forty-one patients (IPF 63%, age 66...
October 10, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28993852/the-effects-of-the-obesogen-tributyltin-on-the-metabolism-of-sertoli-cells-cultured-ex-vivo
#16
Ana M Cardoso, Marco G Alves, Ana C Sousa, Ivana Jarak, Rui A Carvalho, Pedro F Oliveira, José E Cavaco, Luís Rato
Human exposure to environmental contaminants is widespread. Some of these contaminants have the ability to interfere with adipogenesis, being thus considered as obesogens. Recently, obesogens have been singled out as a cause of male infertility. Sertoli cells (SCs) are essential for male fertility and their metabolic performance, especially glucose metabolism, is under a tight endocrine control, being essential for the success of spermatogenesis. Herein, we studied the impact of the model obesogen tributyltin in the metabolic profile of SCs...
October 9, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28993461/brucella-abortus-promotes-a-fibrotic-phenotype-in-hepatic-stellate-cells-with-concomitant-autophagy-pathway-activation
#17
Paula Constanza Arriola Benitez, Ayelén Ivana Pesce Viglietti, Claudia Karina Herrmann, Vida A Dennis, Diego José Comerci, Guillermo Hernán Giambartolomei, María Victoria Delpino
The liver is frequently affected in patients with active brucellosis. The present study demonstrates that B. abortus infection induces the activation of the autophagic pathway in hepatic stellate cells to create a microenvironment that promote a profibrogenic phenotype through the induction of transforming growth factor-β1 (TGF-β1), collagen deposition and inhibition of matrix metalloproteinase-9 (MMP-9) secretion. Autophagy was revealed by up-regulation of the LC3II/LC3I ratio and beclin-1 expression as well as inhibition of p62 expression in infected cells...
October 9, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28993014/-r-%C3%AE-lipoyl-gly-l-pro-l-glu-dimethyl-ester-as-dual-acting-agent-for-the-treatment-of-alzheimer-s-disease
#18
Lisa Marinelli, Erika Fornasari, Antonio Di Stefano, Hasan Turkez, Mehmet Enes Arslan, Piera Eusepi, Michele Ciulla, Ivana Cacciatore
In this study, effects of LA-GPE (R-α-Lipoyl-Gly-l-Pro-l-Glu dimethyl ester) and GPE (Gly-L-Pro-L-Glu) on the cytotoxic action of Aβ1-42 were tested with differentiated human neuroblastoma SH-SY5Y cells as cellular Alzheimer model via measurements of mitochondrial viability (MTT assay) and lactate dehydrogenase release (LDH assay). Effects of LA-GPE and GPE on acetylcholinesterase (AChE) activity, total antioxidant capacity (TAC) and total oxidative status (TOS) levels, and neural cell apoptosis and necrosis were also determined...
October 2, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28992109/integrin-%C3%AE-1-is-bound-to-galectin-1-in-human-trophoblast
#19
Žanka Bojic-Trbojevic, Milica Jovanovic Krivokuca, Ivana Stefanoska, Nikola Kolundžic, Aleksandra Vilotic, Toshihiko Kadoya, Ljiljana Vicovac
Interaction of sugar binding proteins - galectins, with glycoconjugates is considered relevant for various reproductive processes. Galectin-1 (gal-1) is a molecule involved in trophoblast cell invasion, which is accomplished through interaction with cell surface and/or extracellular matrix glycoproteins. A possibility of interaction of endogenous gal-1 and trophoblast β1 integrins, both previously shown relevant for trophoblast invasion, was investigated. Confocal microscopy showed overlap in gal-1 and β1 integrin localization at the plasma membrane of isolated cytotrophoblast, HTR-8/SVneo extravillous trophoblast cell line and JAr choriocarcinoma cells...
September 13, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28990664/hormone-receptors-analysis-in-idiopathic-progressive-subglottic-stenosis
#20
Ivana Fiz, Zeid Bittar, Cesare Piazza, Jan Constantin Koelmel, Federico Gatto, Diego Ferone, Francesco Fiz, Diana Di Dio, Alexander Bosse, Giorgio Peretti, Christian Sittel
OBJECTIVE: Idiopathic subglottic stenosis predominantly affects fertile and perimenopausal women. Estrogens and/or progesterone have been proposed as mediators of its pathogenesis by stimulating collagen deposition within the upper airway. We evaluated the presence and expression of estrogen-alpha (ER-α), estrogen-beta (ER-β), and progesterone receptors (PR) in idiopathic stenotic patients. STUDY DESIGN: A retrospective analysis on 42 surgical specimens from idiopathic stenosis female patients (mean age, 52...
October 9, 2017: Laryngoscope
keyword
keyword
105566
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"