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https://www.readbyqxmd.com/read/29458223/what-does-antidepressant-drug-level-monitoring-reveal-about-outpatient-treatment-and-patient-adherence
#1
Petr Silhan, Romana Urinovska, Ivana Kacirova, Martin Hyza, Milan Grundmann, Eva Ceskova
INTRODUCTION: The evaluation of plasma levels of antidepressants may improve the treatment outcome. The aim was to verify adherence and adequacy of administered doses of antidepressants among patients hospitalized for inadequate outpatient therapeutic response. METHODS: Selective serotonin reuptake inhibitors or venlafaxine plasma levels were assessed on the first day of hospitalization and after 3 days of controlled administration. The patients were considered adherent if the plasma level on admission was within the interval of the minimum and maximum plasma level on the fourth day, expanded by 30%...
February 19, 2018: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29457849/tobacco-attributable-burden-of-cancer-according-to-socioeconomic-position-in-france
#2
Gwenn Menvielle, Ivana Kulhánová, Joséphine Bryère, Guy Launoy, Daniel Eilstein, Cyrille Delpierre, Isabelle Soerjomataram
Smoking is a major preventable cause of cancers and is increasingly concentrated among the most deprived individuals leading to increasing socioeconomic inequalities in the incidence of cancers linked to smoking. We aimed to estimate the tobacco-attributable cancer burden according to socioeconomic position in France. The analysis was restricted to cancer sites for which tobacco smoking was recognized as a risk factor. Cancer cases by sex, age group and European Deprivation Index (EDI) among people aged 30-74 between 2006 and 2009 were obtained from cancer registries covering approximately 20% of the French population...
February 19, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29457261/angiography-vs-transesophageal-echocardiography-guided-patent-foramen-ovale-closure-a-propensity-score-matched-analysis-of-a-two-center-registry
#3
Paolo Scacciatella, Ilaria Meynet, Mauro Giorgi, Lorenza M Biava, Ivana Matranga, Luigi Biasco, Pierluigi Omedè, Fulvio Orzan, Fiorenzo Gaita
OBJECTIVES: The purpose of this study is to compare the long-term outcomes of patent foramen ovale (PFO) closure using angiography or transesophageal echocardiography as procedural guidance. BACKGROUND: The interventional treatment is emerging as a safe and efficient option for patients with high likelihood of PFO-related cryptogenic stroke and high risk of recurrence. The "gold-standard" guidance technique remains an issue. METHODS: Two cohorts of patients undergoing PFO closure for cryptogenic stroke in two catheterization laboratories of the same institution, using similar inclusion criteria but different guidance, were compared with propensity score matching...
February 19, 2018: Echocardiography
https://www.readbyqxmd.com/read/29453638/effects-of-cpap-therapy-on-cognitive-and-psychomotor-performances-in-patients-with-severe-obstructive-sleep-apnea-a-prospective-1-year-study
#4
Renata Pecotic, Ivana Pavlinac Dodig, Maja Valic, Tea Galic, Linda Lusic Kalcina, Natalija Ivkovic, Zoran Dogas
STUDY OBJECTIVES: We prospectively investigated the effects of continuous positive airway pressure (CPAP) on long-term cognitive and psychomotor performances, and excessive daytime sleepiness in severe obstructive sleep apnea (OSA) patients. METHODS: A total of 40 patients were recruited and 23 patients with severe OSA fully completed the study protocol to investigate the effects of CPAP therapy on psychomotor performance at 1, 3, and 6 months and 1 year following initiation of the therapy...
February 16, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29453571/assessing-sertoli-cell-metabolic-activity
#5
Ivana Jarak, Pedro F Oliveira, Gustavo Rindone, Rui A Carvalho, María N Galardo, María F Riera, Silvina B Meroni, Marco G Alves
Nuclear magnetic resonance (NMR)-based metabolomics is widely used in the research of metabolic conditions of complex biological systems under various conditions, and its use has been found in the field of male fertility. Here we describe the implementation of total and targeted NMR-based metabolomics in the research on Sertoli cell metabolism. Main principles and techniques of cell medium, cellular extracts, and intact cells are explained, as well as some classical experiments that can give complementary information on the Sertoli cell metabolism...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29452307/impact-of-metabolic-syndrome-on-clinical-severity-and-long-term-prognosis-in-patients-with-myocardial-infarction-with-st-segment-elevation
#6
Lovic, Dragan B Djordjevic, Ivan S Tasic, Ivana P Nedeljkovic
AIMS: The aim of this study is to evaluate the impact of metabolic syndrome (MetS) on clinical severity and long term prognosis in patients with myocardial infarction with ST segment elevation (STEMI). METHODS: We examined 507 patients with STEMI who were admitted for primary percutaneous coronary intervention classified according to the presence of MetS using American Heart Association and the National Heart, Lung and Blood Institute definition. After applying these criteria, the patients were categorized in patients with MetS and without MetS...
February 13, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29450494/comparison-of-the-performance-of-6-prognostic-signatures-for-estrogen-receptor-positive-breast-cancer-a-secondary-analysis-of-a-randomized-clinical-trial
#7
Ivana Sestak, Richard Buus, Jack Cuzick, Peter Dubsky, Ralf Kronenwett, Carsten Denkert, Sean Ferree, Dennis Sgroi, Catherine Schnabel, Frederick L Baehner, Elizabeth Mallon, Mitch Dowsett
Importance: Multiple molecular signatures are available for managing estrogen receptor (ER)-positive breast cancer but with little direct comparative information to guide the patient's choice. Objective: To conduct a within-patient comparison of the prognostic value of 6 multigene signatures in women with early ER-positive breast cancer who received endocrine therapy for 5 years. Design, Setting, and Participants: This retrospective biomarker analysis included 774 postmenopausal women with ER-positive ERBB2 (formerly HER2)-negative breast cancer...
February 15, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29449174/survival-of-salmonella-spp-in-minced-meat-packaged-under-vacuum-and-modified-atmosphere
#8
Jasna Djordjević, Marija Bošković, Marija Starčević, Jelena Ivanović, Nedjeljko Karabasil, Mirjana Dimitrijević, Ivana Branković Lazić, Milan Ž Baltić
The effect of different modified atmosphere packaging regimes on the behavior of Salmonella spp. on minced meat was studied. Minced meat was experimentally contaminated with a Salmonella spp. cocktail (S. Enteritidis, S. Typhimurium, S. Infantis and S. Arizonae), packaged under vacuum or modified atmosphere with initial headspaces containing 20%O 2 /50%CO 2 /30%N 2 and 20%O 2 /30%CO 2 /50%N 2 ) and stored at 3±1°C for 12 days. Samples were analyzed for Salmonella spp., viable and lactic acid bacteria count every third day...
February 12, 2018: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29448552/plasmonic-screening-effect-of-gold-nanoparticles-array-on-light-absorption-in-poly-3-hexyl-thiophene-thin-film
#9
David Rais, Miroslav Menšík, Bartosz Paruzel, Ivana Šeděnková, Jiří Pfleger
The localized surface plasmon (LSP) photophysical phenomenon occurring in metal nanostructures is often presented as a way to effectively couple light into sub-wavelength-scale photovoltaic devices, which would otherwise suffer from a weak light absorption. The simultaneous complementary effect of localized optical field depletion receives far less attention. We studied a system consisting of a planar gold nanoparticles array (AuNP) deposited at the surface of a semiconducting polymer thin film (P3HT). By comparing the UV-vis spectra of P3HT with and without the AuNP array, we have estimated that the AuNPs screen the optical absorption in the interfacial layer of about 3...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29447353/association-of-strategic-management-with-vaccination-in-the-terms-of-globalization
#10
Mihajo Rabrenovic, Marija Cukanovic Karavidic, Ivana Stosic
Globalization is having an ever growing impact on the field of vaccine production and distribution in the world and domestically. In this article we examine the impact of taking a strategic approach to vaccination programmes by all the relevant actors: WHO, UNICEF, national immunization programmes, and vaccine manufacturers and distributors. The review of the relevant literature indicates that there are commonalities to the worldwide vaccination programmes. A comparative analysis of various vaccination strategies recommended by WHO and the immunization calendars of certain European countriesis made as well as an analysis of the Serbian vaccination programme...
February 13, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29446144/animal-models-of-multiple-sclerosis-focus-on-experimental-autoimmune-encephalomyelitis
#11
REVIEW
Ivana Bjelobaba, Vesna Begovic-Kupresanin, Sanja Pekovic, Irena Lavrnja
Multiple sclerosis (MS) is a chronic, progressive disorder of the central nervous system (CNS) that affects more than two million people worldwide. Several animal models resemble MS pathology; the most employed are experimental autoimmune encephalomyelitis (EAE) and toxin- and/or virus-induced demyelination. In this review we will summarize our knowledge on the utility of different animal models in MS research. Although animal models cannot replicate the complexity and heterogeneity of the MS pathology, they have proved to be useful for the development of several drugs approved for treatment of MS patients...
February 15, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29443929/claimed-effects-outcome-variables-and-methods-of-measurement-for-health-claims-on-foods-related-to-vision-proposed-under-regulation-ec-1924-2006
#12
Daniela Martini, Augusto Innocenti, Chiara Cosentino, Giorgio Bedogni, Donato Angelino, Beatrice Biasini, Ivana Zavaroni, Marco Ventura, Daniela Galli, Prisco Mirandola, Marco Vitale, Alessandra Dei Cas, Riccardo C Bonadonna, Giovanni Passeri, Carlo Pruneti, Daniele Del Rio
Adequate visual function has a strong impact on the quality of life of people. Several foods and food components have been hypothesized to play a role in the maintenance of normal visual function and in the prevention of eye diseases. Some of these foods/food components have been the object of a request of authorization for use of health claims under Articles 13(5) or 14 of the Regulation (EC) 1924/2006. Most of these requests have received a negative opinion from the European Food Safety Authority (EFSA) due to the choice of inappropriate outcome variables (OVs) and/or methods of measurement (MMs) applied in the studies used to substantiate the claims...
February 14, 2018: Nutrients
https://www.readbyqxmd.com/read/29441349/liquid-biopsy-in-clinical-management-of-breast-lung-and-colorectal-cancer
#13
REVIEW
Ivana Bratić Hench, Jürgen Hench, Markus Tolnay
Examination of tumor molecular characteristics by liquid biopsy is likely to greatly influence personalized cancer patient management. Analysis of circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and tumor-derived exosomes, all collectively referred to as "liquid biopsies," are not only a modality to monitor treatment efficacy, disease progression, and emerging therapy resistance mechanisms, but they also assess tumor heterogeneity and evolution in real time. We review the literature concerning the examination of ctDNA and CTC in a diagnostic setting, evaluating their prognostic, predictive, and monitoring capabilities...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29439692/automated-chart-review-utilizing-natural-language-processing-algorithm-for-asthma-predictive-index
#14
Harsheen Kaur, Sunghwan Sohn, Chung-Il Wi, Euijung Ryu, Miguel A Park, Kay Bachman, Hirohito Kita, Ivana Croghan, Jose A Castro-Rodriguez, Gretchen A Voge, Hongfang Liu, Young J Juhn
BACKGROUND: Thus far, no algorithms have been developed to automatically extract patients who meet Asthma Predictive Index (API) criteria from the Electronic health records (EHR) yet. Our objective is to develop and validate a natural language processing (NLP) algorithm to identify patients that meet API criteria. METHODS: This is a cross-sectional study nested in a birth cohort study in Olmsted County, MN. Asthma status ascertained by manual chart review based on API criteria served as gold standard...
February 13, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29435164/overexpression-of-na-mg2-exchanger-slc41a1-attenuates-pro-survival-signaling
#15
Gerhard Sponder, Nasrin Abdulhanan, Nadine Fröhlich, Lucia Mastrototaro, Jörg R Aschenbach, Monika Röntgen, Ivana Pilchova, Michal Cibulka, Peter Racay, Martin Kolisek
The Na+/Mg2+ exchanger SLC41A1 (A1), a key component of intracellular Mg homeostasis (IMH), is the major cellular Mg2+ efflux system, and its overexpression decreases [Mg2+]intracellular. IMH plays an important role in the regulation of many cellular processes, including cellular signaling. However, whether the overexpression of A1 and the consequent drop of [Mg2+]i impact on intracellular signaling is unknown. To examine the latter, we utilized dynamic mass redistribution (DMR) assay, PathScan® RTK signaling antibody (PRSA) array, confirmatory Western blot (WB) analyses of phosphorylation of kinases selected by PRSA, and mag-fura 2-assisted fast filter spectrometry (FFS)...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29434601/inhibition-of-osteoblast-function-by-brucella-abortus-is-reversed-by-dehydroepiandrosterone-and-involves-erk1-2-and-estrogen-receptor
#16
María Virginia Gentilini, Ayelén Ivana Pesce Viglietti, Paula Constanza Arriola Benitez, Andrea Elena Iglesias Molli, Gloria Edith Cerrone, Guillermo Hernán Giambartolomei, María Victoria Delpino
Brucella abortus induces an inflammatory response that stimulates the endocrine system resulting in the secretion of cortisol and dehydroepiandrosterone (DHEA). Osteoarticular brucellosis is the most common presentation of the active disease in humans, and we have previously demonstrated that B. abortus infection inhibits osteoblast function. We aimed to evaluate the role of cortisol and DHEA on osteoblast during B. abortus infection. B. abortus infection induces apoptosis and inhibits osteoblast function. DHEA treatment reversed the effect of B...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29433161/the-allele-2-of-the-vntr-polymorphism-in-the-gene-that-encodes-a-natural-inhibitor-of-il-1%C3%AE-il-1ra-is-favorably-associated-with-chronic-otitis-media
#17
Maja Živković, Ivana Kolić, Snežana Jesić, Ana Jotić, Aleksandra Stanković
Objectives: Chronic otitis media (COM) is followed by irreversible tissue damage and destruction of the middle ear structures, with the possibility of complications under the maintenance of inflammation. Inflammatory mediators such as cytokines play a crucial role in the initial stage of inflammation. The aim of this study was to evaluate the association of the polymorphisms in two innate immunity/inflammation cascade genes from interleukin-1 (IL-1) gene cluster with COM with regard to cholesteatoma...
February 14, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29432621/implementation-of-the-autovalidation-algorithm-for-clinical-chemistry-testing-in-the-laboratory-information-system
#18
Vladimira Rimac, Ivana Lapic, Kresimir Kules, Dunja Rogic, Marijana Miler
Objective: Autovalidation algorithm should be properly designed with clearly defined criteria and any data that do not meet the criteria, must be reviewed and manually validated. The aim was to define the rules for autovalidation in our laboratory information system (LIS), and validate the algorithm prior to its implementation in routine laboratory work. Methods: Autovalidation was implemented for all routine serum biochemistry tests. The algorithm included analytical measurement ranges (AMR), delta check, critical values, serum indices and all preanalytical and analytical flags from the analyzer...
February 8, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29432300/dopamine-modulates-striatal-response-to-reward-and-punishment-in-patients-with-parkinson-s-disease-a-pharmacological-challenge-fmri-study
#19
Miklos Argyelan, Mohammad Herzallah, Wataru Sako, Ivana DeLucia, Deepak Sarpal, An Vo, Toni Fitzpatrick, Ahmed A Moustafa, David Eidelberg, Mark Gluck
It is well established that Parkinson's disease leads to impaired learning from reward and enhanced learning from punishment. The administration of dopaminergic medications reverses this learning pattern. However, few studies have investigated the neural underpinnings of these cognitive processes. In this study, using fMRI, we tested a group of Parkinson's disease patients on and off dopaminergic medications and matched healthy individuals. All individuals completed an fMRI cognitive task that dissociates feedback learning from reward versus punishment...
February 9, 2018: Neuroreport
https://www.readbyqxmd.com/read/29431203/changing-the-threshold-signals-and-mechanisms-of-mast-cell-priming
#20
REVIEW
Ivana Halova, Elin Rönnberg, Lubica Draberova, Harissios Vliagoftis, Gunnar P Nilsson, Petr Draber
Mast cells play a key role in allergy and other inflammatory diseases involving engagement of multivalent antigen with IgE bound to high-affinity IgE receptors (FcεRIs). Aggregation of FcεRIs on mast cells initiates a cascade of signaling events that eventually lead to degranulation, secretion of leukotrienes and prostaglandins, and cytokine and chemokine production contributing to the inflammatory response. Exposure to pro-inflammatory cytokines, chemokines, bacterial and viral products, as well as some other biological products and drugs, induces mast cell transition from the basal state into a primed one, which leads to enhanced response to IgE-antigen complexes...
March 2018: Immunological Reviews
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