keyword
https://read.qxmd.com/read/38536125/overcoming-solubility-challenges-liposomal-isocoq-carbazole-as-a-promising-anti-tumor-agent-for-inoperable-and-radiation-insensitive-cancers
#1
JOURNAL ARTICLE
Diana Lamaa, Catherine Cailleau, Juliette Vergnaud, Julie Mougin, Jérôme Bignon, Mouad Alami, Elias Fattal, Abdallah Hamze, Nicolas Tsapis
This study evaluated the potential of isoCoQ-Carbazole, a diheterocyclic analog of isoCA-4, as an anti-tumor agent. To overcome its low aqueous solubility, liposomes were developed as a delivery system for the compound. In vitro experiments showed that loaded liposomes exhibited similar activity to the free form on multiple human tumor cell lines. In vivo experiments using a palliative intratumoral injection chemotherapy approach further demonstrated that isoCoQ-Carbazole loaded liposomes significantly reduced tumor growth in a CA-4-resistant HT29 cell model, without inducing any observable toxicity or weight loss in the treated mice...
March 27, 2024: Chembiochem: a European Journal of Chemical Biology
https://read.qxmd.com/read/38536064/ag-in-zn-s-alloyed-nanocrystals-as-photocatalysts-of-controlled-light-mediated-radical-polymerization
#2
JOURNAL ARTICLE
Patrycja Kowalik, Piotr Bujak, Mateusz Penkala, Anna Iuliano, Ireneusz Wielgus, Karolina Peret, Adam Pron
We report on the first case of the use of nonstoichiometric ternary (Ag-In-Zn-S) semiconductor nanocrystals as photoinitiators and photocatalysts of methyl methacrylate (MMA) polymerization. Two types of nanocrystals were tested, differing in their composition and characterized by red ( λ max = 731 nm) and green ( λ max = 528 nm) photoluminescence, respectively. Exploiting their reducing properties and capability of free radical generation we demonstrate that under ultraviolet (UV) radiation they effectively photoinitiate radical polymerization of MMA whereas under visible light (blue or green) they act as photocatalysts of living radical polymerization...
March 27, 2024: Chemical Communications: Chem Comm
https://read.qxmd.com/read/38533887/excitons-optical-spectra-and-electronic-properties-of-semiconducting-hf-based-mxenes
#3
JOURNAL ARTICLE
Nilesh Kumar, Miroslav Kolos, Sitangshu Bhattacharya, František Karlický
Semiconducting MXenes are an intriguing two-dimensional (2D) material class with promising electronic and optoelectronic properties. Here, we focused on recently prepared Hf-based MXenes, namely, Hf3C2O2 and Hf2CO2. Using the first-principles calculation and excited state corrections, we proved their dynamical stability, reconciled their semiconducting behavior, and obtained fundamental gaps by using the many-body GW method (indirect 1.1 and 2.2 eV; direct 1.4 and 3.5 eV). Using the Bethe-Salpeter equation, we subsequently provided optical gaps (0...
March 28, 2024: Journal of Chemical Physics
https://read.qxmd.com/read/38533806/improved-effectiveness-of-x-pdt-against-human-triple-negative-breast-cancer-cells-through-the-use-of-liposomes-co-loaded-with-protoporphyrin-ix-and-perfluorooctyl-bromide
#4
JOURNAL ARTICLE
Biyao Yang, Rui Sang, Yi Li, Ewa M Goldys, Wei Deng
In this study, we utilized X-ray-induced photodynamic therapy (X-PDT) against triple-negative breast cancer (TNBC) cells. To achieve this, we developed a liposome delivery system that co-loaded protoporphyrin IX (PPIX) and perfluorooctyl bromide (PFOB) in a rational manner. Low-dose X-ray at 2 Gy was employed to activate PPIX for the generation of reactive oxygen species (ROS), and the co-loading of PFOB provided additional oxygen to enhance ROS production. The resulting highly toxic ROS effectively induced cell death in TNBC...
March 27, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38530278/selective-enhancement-of-6-4-photoproduct-formation-in-dithymine-dinucleotides-driven-by-specific-sugar-puckering
#5
JOURNAL ARTICLE
Jouda Jakhlal, Clément Denhez, Stéphanie Coantic-Castex, Agathe Martinez, Dominique Harakat, Thierry Douki, Dominique Guillaume, Pascale Clivio
Four dinucleotide analogs of thymidylyl(3'-5')thymidine (TpT) have been designed and synthesized with a view to increase the selectivity, with respect to CPD, of efficient UV-induced (6-4) photoproduct formation. The deoxyribose residues of these analogs have been modified to increase north and south conformer populations at 5'- and 3'-ends, respectively. Dinucleotides whose 5'-end north population exceeds ca. 60% and whose 3'-end population is almost completely south display a three-fold selective enhancement in (6-4) adduct production when exposed to UV radiation, compared to TpT...
March 26, 2024: Organic & Biomolecular Chemistry
https://read.qxmd.com/read/38530229/superoxide-radicals-in-uranyl-peroxide-solids-lasting-signatures-identified-by-electron-paramagnetic-resonance-spectroscopy
#6
JOURNAL ARTICLE
Sarah Scherrer, Cassandra Gates, Harindu Rajapaksha, Samuel Greer, Benjamin Stein, Tori Forbes
U(VI) peroxide phases (studtite and meta-studtite) are found throughout the nuclear fuel cycle and exist as corrosion products in high radiation fields.  Peroxides are part of a family of reactive oxygen species (ROS) that include hydroperoxyl and superoxide species and are produced during alpha radiolysis of water.  While U(VI) peroxides have been thoroughly investigated, the incorporation and stability of ROS species within studtite have not been validated. In the current study, electron paramagnetic resonance (EPR) spectroscopy was used to identify the presence of free radicals within a series of U(VI) peroxide samples containing depleted, weapons-grade, and natural uranium...
March 26, 2024: Angewandte Chemie
https://read.qxmd.com/read/38529608/liposomal-nano-based-drug-delivery-systems-for-breast-cancer-therapy-recent-advances-and-progresses
#7
JOURNAL ARTICLE
Mostafa Yazdan, Seyed Morteza Naghib, M R Mozafari
Breast cancer is a highly prevalent disease on a global scale, with a 30% incidence rate among women and a 14% mortality rate. Developing countries bear a disproportionate share of the disease burden, while countries with greater technological advancements exhibit a higher incidence. A mere 7% of women under the age of 40 are diagnosed with breast cancer, and the prevalence of this ailment is significantly diminished among those aged 35 and younger. Chemotherapy, radiation therapy, and surgical intervention comprise the treatment protocol...
March 25, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38528435/inorganic-organic-hybrid-layered-semiconductor-agseph-quasi-solution-synthesis-optical-properties-and-thermolysis-behavior
#8
JOURNAL ARTICLE
Kewei Gu, Tingting Wang, Guowei Yang, Nan Yu, Chengchao Du, Junli Wang
Two-dimensional inorganic-organic hybrid layered semiconductors are actively studied because of their naturally formed multiquantum well (MQW) structures and associated optical, photoelectric, and quantum optics characteristics. Silver benzeneselenolate (AgSePh, Ph = C6 H5 ) is a new member of such hybrid layered materials, but has not fully been exploited. Herein, we present a quasi-solution method to prepare high quality free-standing AgSePh flake-like microcrystals by reacting diphenyl diselenide (Ph2 Se2 ) with silver nanoparticles...
March 25, 2024: Inorganic Chemistry
https://read.qxmd.com/read/38527959/fluorinated-polyimide-tunneling-layer-for-efficient-and-stable-perovskite-photovoltaics
#9
JOURNAL ARTICLE
Chunming Liu, Wei Yu, Yuheng Li, Can Wang, Zilong Zhang, Chi Li, Lusheng Liang, Kangcheng Chen, Lin Liu, Tinghao Li, Xuteng Yu, Yao Wang, Peng Gao
Despite the remarkable progress of perovskite solar cells (PSCs), challenges remain in terms of finding effective and viable strategies to enhance their long-term stability while maintaining high efficiency. In this study, a new insulating and hydrophobic fluorinated polyimide (FPI: 6FDA-6FAPB) was used as the interface layer between the perovskite layer and the hole transport layer (HTL) in PSCs. The functional groups of FPI play a pivotal role in passivating interface defects within the device. Due to its high work function, FPI demonstrates field-effect passivation (FEP) capabilities as an interface layer, effectively mitigating non-radiative recombination at the interface...
March 25, 2024: Angewandte Chemie
https://read.qxmd.com/read/38526934/probing-the-dynamic-landscape-from-static-to-time-resolved-x-ray-absorption-spectroscopy-to-investigate-copper-redox-chemistry-in-neurodegenerative-disorders
#10
JOURNAL ARTICLE
Emiliano De Santis, Stefania Alleva, Velia Minicozzi, Francesco Stellato
Copper (Cu), capable of existing in various oxidation states, notably Cu(I) and Cu(II), plays a pivotal role in diverse biological redox reactions. This includes its involvement in pathways associated with oxidative stress in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Transmissible Spongiform Encephalopathies. This paper offers an overview of X-ray Absorption Spectroscopy (XAS) studies designed to elucidate the interactions between Cu ions and proteins or peptides associated with these neurodegenerative diseases...
March 25, 2024: ChemPlusChem
https://read.qxmd.com/read/38525159/nir-ii-emissive-donor-acceptor-donor-fluorophores-for-dual-fluorescence-bioimaging-and-photothermal-therapy-applications
#11
JOURNAL ARTICLE
Nicholas E Sparks, Cameron Smith, Terrence Stahl, Dhanush L Amarasekara, Christine Hamadani, Ethan Lambert, Sheng Wei Tang, Anuja Kulkarni, Blaine M Derbigny, Gaya S Dasanayake, George Taylor, Maryam Ghazala, Nathan I Hammer, Alexander Y Sokolov, Nicholas C Fitzkee, Eden E L Tanner, Davita L Watkins
Fluorescence bioimaging with near-infrared II (NIR-II) emissive organic fluorophores has proven to be a viable noninvasive diagnostic technique. However, there is still the need for the development of fluorophores that possess increased stability as well as functionalities that impart stimuli responsiveness. Through strategic design, we can synthesize fluorophores that possess not only NIR-II optical profiles but also pH-sensitivity and the ability to generate heat upon irradiation. In this work, we employ a donor-acceptor-donor (D-A-D) design to synthesize a series of NIR-II fluorophores...
March 21, 2024: Journal of Materials Chemistry. C, Materials for Optical and Electronic Devices
https://read.qxmd.com/read/38522515/emergence-of-two-distinct-spatial-folds-in-a-pair-of-plant-virus-proteins-encoded-by-nested-genes
#12
JOURNAL ARTICLE
Esmeralda G Legarda, Santiago F Elena, Arcady R Mushegian
Virus genomes may encode overlapping or nested open reading frames that increase their coding capacity. It is not known whether the constraints on spatial structures of the two encoded proteins limit evolvability of nested genes. We examine the evolution of a pair of proteins, p22 and p19, encoded by nested genes in plant viruses from the genus Tombusvirus. The known structure of p19, a suppressor of RNA silencing, belongs to the RAGNYA fold from the alpha+beta class. The structure of p22, the cell-to-cell movement protein from the 30K family widespread in plant viruses, is predicted with the AlphaFold approach, suggesting a single jelly-roll fold core from the all-beta class, structurally similar to capsid proteins from plant and animal viruses...
March 22, 2024: Journal of Biological Chemistry
https://read.qxmd.com/read/38519031/dual-specificity-kinase-dyrk3-phosphorylates-p62-at-the-thr-269-residue-and-promotes-melanoma-progression
#13
JOURNAL ARTICLE
Ye Hyung Lee, A-Rum Yoon, Chae-Ok Yun, Kwang Chul Chung
Melanoma is a type of skin cancer that originates in melanin-producing melanocytes. It is considered a multifactorial disease caused by both genetic and environmental factors, such as UV radiation. Dual-specificity tyrosine-phosphorylation-regulated kinase (DYRK) phosphorylates many substrates involved in signaling pathways, cell survival, cell cycle control, differentiation, and neuronal development. However, little is known about the cellular function of DYRK3, one of the five members of the DYRK family. Interestingly, it was observed that the expression of DYRK3, as well as p62 (a multifunctional signaling protein), is highly enhanced in most melanoma cell lines...
March 20, 2024: Journal of Biological Chemistry
https://read.qxmd.com/read/38518996/targeting-aryl-hydrocarbon-receptor-to-prevent-cancer-in-barrier-organs
#14
REVIEW
Francoise Congues, Pengcheng Wang, Joshua Lee, Daphne Lin, Ayaz Shahid, Jianming Xie, Ying Huang
The skin, lung, and gut are important barrier organs that control how the body reacts to environmental stressors such as ultraviolet (UV) radiation, air pollutants, dietary components, and microorganisms. The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that plays an important role in maintaining homeostasis of barrier organs. AhR was initially discovered as a receptor for environmental chemical carcinogens such as polycyclic aromatic hydrocarbons (PAHs). Activation of AhR pathways by PAHs leads to increased DNA damage and mutations which ultimately lead to carcinogenesis...
March 20, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38518524/radioprotective-effectiveness-of-a-novel-delta-tocotrienol-prodrug-on-mouse-hematopoietic-system-against-60-co-gamma-ray-irradiation-through-inducing-granulocyte-colony-stimulating-factor-production
#15
JOURNAL ARTICLE
Zongchao Zuo, Limei Wang, Shaozheng Wang, Xinyu Liu, Dandan Wu, Zhangyi Ouyang, Ruoxi Meng, Yajun Shan, Shouguo Zhang, Tao Peng, Lin Wang, Zhongtang Li, Yuwen Cong
Considering the increasing risk of nuclear attacks worldwide, the development of develop potent and safe radioprotective agents for nuclear emergencies is urgently needed. γ-tocotrienol (GT3) and δ-tocotrienol (DT3) have demonstrated a potent radioprotective effect by inducing the production of granulocyte-colony stimulating factor (G-CSF) in vivo. However, their application is limited because of their low bioavailability. The utilization of ester prodrugs can be an effective strategy for modifying the pharmacokinetic properties of drug molecules...
March 19, 2024: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/38518445/novel-strategies-for-enhancing-quality-stability-of-edible-flower-during-processing-using-efficient-physical-fields-a-review
#16
JOURNAL ARTICLE
Min Feng, Min Zhang, Benu Adhikari, Lu Chang
Edible flowers are an exotic part of the human diet due to their distinct sensorial properties and health benefits. Due to consumers demand edible flowers and their products with natural freshness and high nutritional value, there is increasing research on the application of green and efficient edible flower processing technologies. This paper reviews the application of a number of physical fields including ultrasound, microwave, infrared, ultraviolet, ionizing radiation, pulse electric field, high hydrostatic pressure, and reduced pressure aiming to improve the processing and product quality of edible flowers...
March 20, 2024: Food Chemistry
https://read.qxmd.com/read/38516096/long-live-d-cspbbr-3-superlattices-colloidal-atomic-layer-deposition-for-structural-stability
#17
JOURNAL ARTICLE
Victoria Lapointe, Philippe B Green, Alexander N Chen, Raffaella Buonsanti, Marek B Majewski
Superlattice formation afforded by metal halide perovskite nanocrystals has been a phenomenon of interest due to the high structural order induced in these self-assemblies, an order that is influenced by the surface chemistry and particle morphology of the starting building block material. In this work, we report on the formation of superlattices from aluminum oxide shelled CsPbBr3 perovskite nanocrystals where the oxide shell is grown by colloidal atomic layer deposition. We demonstrate that the structural stability of these superlattices is preserved over 25 days in an inert atmosphere and that colloidal atomic layer deposition on colloidal perovskite nanocrystals yields structural protection and an enhancement in photoluminescence quantum yields and radiative lifetimes as opposed to gas phase atomic layer deposition on pre-assembled superlattices or excess capping group addition...
March 20, 2024: Chemical Science
https://read.qxmd.com/read/38513902/understanding-changes-in-holocellulose-and-lignin-compounds-in-wooden-structure-of-veneers-molecular-insights-post-hydrothermal-treatment-and-aging
#18
JOURNAL ARTICLE
Anna Szwajca, Jeannette Jacqueline Lucejko, Natalia Berdychowska, Magdalena Zborowska
Veneers obtained via hydrothermal treatment serve to enhance the aesthetic appeal of furniture and other wooden surfaces. However, the impact of this treatment on the chemical composition of holocellulose and lignin, coupled with their resistance to ultraviolet (UV) irradiation, remains a relatively unexplored area requiring further investigation. In the experiment, wood samples of three distinct species underwent hydrothermal treatment followed by exposure to UV aging. Parameters including colour, contact angle, and acid-base properties were examined alongside their chemical alterations during these processes...
March 19, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38513473/glutathione-ligand-self-assembly-enables-luminescence-from-au-15-nanoclusters-for-highly-sensitive-and-selective-monitoring-of-blood-pb-ii-ions
#19
JOURNAL ARTICLE
Chang Yuan, Zhanjun Guo, Shubo Tian, Ningning Song, Minmin Liang
Lead Pb(II) ions is a cumulative toxicant that impacts several biological systems and poses severe harm to young children. Accurate Pb(II) ions monitoring is thus of paramount importance. Here, we present the synthesis and application of glutathione-capped Au15 nanoclusters (Au15 (SG)13 ) as a luminescence probe for the accurate and selective monitoring of blood Pb(II). The introduction of Pb(II) ions triggers orderly self-assembly of Au15 nanoclusters, resulting in the formation of rigid shell around Au nuclei...
March 11, 2024: Talanta
https://read.qxmd.com/read/38509936/translating-microcalcification-biomarker-information-into-the-laboratory-a-preliminary-assessment-utilizing-core-biopsies-obtained-from-sites-of-mammographic-calcification
#20
JOURNAL ARTICLE
Iain D Lyburn, Robert Scott, Eleanor Cornford, Pascaline Bouzy, Nicholas Stone, Charlene Greenwood, Ihsanne Bouybayoune, Sarah E Pinder, Keith Rogers
RATIONALE AND OBJECTIVES: The potential of breast microcalcification chemistry to provide clinically valuable intelligence is being increasingly studied. However, acquisition of crystallographic details has, to date, been limited to high brightness, synchrotron radiation sources. This study, for the first time, evaluates a laboratory-based system that interrogates histological sections containing microcalcifications. The principal objective was to determine the measurement precision of the laboratory system and assess whether this was sufficient to provide potentially clinical valuable information...
March 30, 2024: Heliyon
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