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https://www.readbyqxmd.com/read/28322202/genetic-epistasis-regulates-amyloid-deposition-in-resilient-aging
#1
Daniel Felsky, Jishu Xu, Lori Chibnik, Julie Schneider, Jo Knight, James L Kennedy, David A Bennett, Philip L De Jager, Aristotle N Voineskos
INTRODUCTION: The brain-derived neurotrophic factor (BDNF) interacts with important genetic Alzheimer's disease (AD) risk factors. Specifically, variants within the SORL1 gene determine BDNF's ability to reduce amyloid β (Aβ) in vitro. We sought to test whether functional BDNF variation interacts with SORL1 genotypes to influence expression and downstream AD-related processes in humans. METHODS: We analyzed postmortem brain RNA sequencing and neuropathological data for 441 subjects from the Religious Orders Study/Memory and Aging Project and molecular and structural neuroimaging data for 1285 subjects from the Alzheimer's Disease Neuroimaging Initiative...
March 16, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28264580/-ethical-aspects-of-uterus-transplantation
#2
Roman Chmel, Marta Nováčková, Zlatko Pastor, Jan Matěcha, Miloš Čekal, Jiří Froněk
Uterus transplantation is an experimental treatment method with an ambition to become accepted treatment modality for women with absolute uterine factor infertility. The only legal alternative for these women to get parenthood is adoption which is accepted by most world societies and countries. Surrogate pregnancy is connected with many medical, ethical, legal, religious and social controversies in the great part of the world.Donors (in living donation), recipients, partners and also unborn children must be incorporated into the analysis of ethical risks and benefits of uterus transplantation...
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28235884/is-there-a-place-for-cpr-and-sustained-physiological-support-in-brain-dead-non-donors
#3
Stephen D Brown
This article addresses whether cardiopulmonary resuscitation (CPR) and sustained physiological support should ever be permitted in individuals who are diagnosed as brain dead and who had held previously expressed moral or religious objections to the currently accepted criteria for such a determination. It contrasts how requests for care would normally be treated in cases involving a brain-dead individual with previously expressed wishes to donate and a similarly diagnosed individual with previously expressed beliefs that did not conform to a brain-based conception of death...
February 24, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28078616/physician-power-to-declare-death-by-neurologic-criteria-threatened
#4
Ariane Lewis, Thaddeus Mason Pope
BACKGROUND: Three recent lawsuits that address declaration of brain death (BD) garnered significant media attention and threaten to limit physician power to declare BD. METHODS: We discuss these cases and their consequences including: the right to refuse an apnea test, accepted medical standards for declaration of BD, and the irreversibility of BD. RESULTS: These cases warrant discussion because they threaten to: limit physicians' power to determine death; incite families to seek injunctions to continue organ support after BD; and force hospitals to dispense valuable resources to dead patients in lieu of patients with reparable illnesses or injuries...
January 11, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28065775/group-focused-morality-is-associated-with-limited-conflict-detection-and-resolution-capacity-neuroanatomical-evidence
#5
Kyle Nash, Thomas Baumgartner, Daria Knoch
Group-focused moral foundations (GMFs) - moral values that help protect the group's welfare - sharply divide conservatives from liberals and religiously devout from non-believers. However, there is little evidence about what drives this divide. Moral foundations theory and the model of motivated social cognition both associate group-focused moral foundations with differences in conflict detection and resolution capacity, but in opposing directions. Individual differences in conflict detection and resolution implicate specific neuroanatomical differences...
January 5, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28063092/was-hawan-designed-to-fight-anxiety-scientific-evidences
#6
R K Romana, A Sharma, V Gupta, R Kaur, S Kumar, P Bansal
Anxiety is a psychiatric disorder with unknown neurobiology; however, neurotransmitters like gamma-amino butyric acid, norepinephrine and serotonin (5-HT) play crucial roles in mediating anxiety. Present drug modules pose dependence risk to the patient; hence, there is a great need to develop complementary therapies to fight this disorder. Aromatherapy has also been employed in ancient times for a number of mental disorders. Mahamrituanjay Mantra, Om triambkum yajamahe, sughandhim puushtivardhanam, urvarukmev vandhanaat, mrityu mokshay mamritaat!!!!, the part of veda enlightens that aroma gives rise to good health (sughandhim puushtivardhanam)...
January 6, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28054711/nature-meets-nurture-in-religious-and-spiritual-development
#7
Pehr Granqvist, Frances Nkara
We consider nurture's (including culture's) sculpting influences on the evolved psychological predispositions that are expressed in religious and spiritual (R&S) development. An integrated understanding of R&S development requires a move away from the largely one-sided (nature-or-nurture) and additive (nature + nurture) accounts provided in the extant literature. R&S development has been understood as an expression of evolved cognitive modules (nature) on the one hand, and of socialization and social learning (nurture) on the other, or in similar albeit additive terms (e...
January 5, 2017: British Journal of Developmental Psychology
https://www.readbyqxmd.com/read/28041787/brain-mechanisms-in-religion-and-spirituality-an-integrative-predictive-processing-framework
#8
REVIEW
Michiel van Elk, André Aleman
We present the theory of predictive processing as a unifying framework to account for the neurocognitive basis of religion and spirituality. Our model is substantiated by discussing four different brain mechanisms that play a key role in religion and spirituality: temporal brain areas are associated with religious visions and ecstatic experiences; multisensory brain areas and the default mode network are involved in self-transcendent experiences; the Theory of Mind-network is associated with prayer experiences and over attribution of intentionality; top-down mechanisms instantiated in the anterior cingulate cortex and the medial prefrontal cortex could be involved in acquiring and maintaining intuitive supernatural beliefs...
February 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28030554/procedures-and-frequencies-of-embalming-and-heart-extractions-in-modern-period-in-brittany-contribution-to-the-evolution-of-ritual-funerary-in-europe
#9
Rozenn Colleter, Fabrice Dedouit, Sylvie Duchesne, Fatima-Zohra Mokrane, Véronique Gendrot, Patrice Gérard, Henri Dabernat, Éric Crubézy, Norbert Telmon
The evolution of funeral practices from the Middle Ages through the Modern era in Europe is generally seen as a process of secularization. The study, through imaging and autopsy, of two mummies, five lead urns containing hearts, and more than six hundred skeletons of nobles and clergymen from a Renaissance convent in Brittany has led us to reject this view. In addition to exceptional embalming, we observed instances in which hearts alone had been extracted, a phenomenon that had never before been described, and brains alone as well, and instances in which each spouse's heart had been placed on the other's coffin...
2016: PloS One
https://www.readbyqxmd.com/read/27909606/knowledge-levels-and-attitudes-of-people-living-in-the-city-centre-of-nev%C3%A5-ehir-on-organ-donation-and-transplantation
#10
Mehmet Akif Yazar, Mehmet Barış Açıkgöz
OBJECTIVE: The purpose of this descriptive study was to determine the knowledge levels and attitudes of people living in Nevşehir on organ donation (OD) and transplantation. METHODS: Data were collected using a questionnaire administered to 414 people residing in Nevşehir between February and May 2016. The primary and secondary endpoints of the present study were to determine the attitudes and knowledge levels of participants on OD and transplantation, respectively...
October 2016: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/27834117/reward-salience-and-attentional-networks-are-activated-by-religious-experience-in-devout-mormons
#11
Michael A Ferguson, Jared A Nielsen, Jace B King, Li Dai, Danielle M Giangrasso, Rachel Holman, Julie R Korenberg, Jeffrey S Anderson
High-level cognitive and emotional experience arises from brain activity, but the specific brain substrates for religious and spiritual euphoria remain unclear. We demonstrate using functional magnetic resonance imaging scans in 19 devout Mormons that a recognizable feeling central to their devotional practice was reproducibly associated with activation in nucleus accumbens, ventromedial prefrontal cortex, and frontal attentional regions. Nucleus accumbens activation preceded peak spiritual feelings by 1-3 s and was replicated in four separate tasks...
November 29, 2016: Social Neuroscience
https://www.readbyqxmd.com/read/27788784/assessment-of-attitude-and-knowledge-of-personnel-in-the-intensive-care-unit-of-tabriz-university-of-medical-sciences-hospitals-toward-organ-donation
#12
K S Nia, A Tagizadieh, M Pouraghaei, H Soleimanpour, F Kakaie, S Sanaie, A Mahmoodpoor
BACKGROUND: The increasing gap between organ supply and demand remains a worldwide problem and can be attributed to several reasons. Because health care workers play an important role in management of brain dead patients, we performed a survey to evaluate the attitude and knowledge of personnel in the intensive care unit (ICU) at Tabriz University of Medical Sciences hospitals toward organ donation. MATERIALS AND METHODS: This cross-sectional study was included personnel from 8 university affiliated ICUs in Northwest of Iran from May to July 2014...
October 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27742313/knowledge-attitudes-and-beliefs-toward-organ-donation-among-social-media-users
#13
W M Hajjar, S A Bin Abdulqader, S S Aldayel, A W Alfardan, N I Alzaidy
BACKGROUND: Organ transplantation is the optimal treatment for end-stage organ diseases. The demand for organs has exceeded the available supply, which becomes a major obstacle worldwide. Identifying the factors affecting this gap will help in overcoming this obstacle. The purpose of the work was to study the knowledge, attitudes, and beliefs of organ donation and to determine the knowledge of brain death among social media users. METHODS: A cross-sectional study was conducted among social media users living in Saudi Arabia...
September 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27738901/the-history-of-head-transplantation-a-review
#14
REVIEW
Nayan Lamba, Daniel Holsgrove, Marike L Broekman
BACKGROUND: Since the turn of the last century, the prospect of head transplantation has captured the imagination of scientists and the general public. Recently, head transplant has regained attention in popular media, as neurosurgeons have proposed performing this procedure in 2017. Given the potential impact of such a procedure, we were interested in learning the history of the technical hurdles that need to be overcome, and determine if it is even technically possible to perform such a procedure on humans today...
December 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27717736/-factors-influencing-the-choice-of-nondonor-families-in-a-french-organ-harvesting-center
#15
F Hénon, J Le Nobin, A Ouzzane, A Villers, G Strecker, S Bouyé
OBJECTIVES: Report the reasons that lead families to refuse organ donation during their close solicitation by hospital coordination. MATERIAL AND METHODS: A retrospective study was conducted between 2012 and 2015, including 148 (34%) refusal of organ donation among 426 patients identified in a state of brain death. A questionnaire of the family was completed for each interview. Collected data concerned patient characteristics, cause of death, description of the interview and reasons for refusal...
September 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27697237/determination-of-death-metaphysical-and-biomedical-discourse
#16
REVIEW
Irayda Jakušovaitė, Žydrunė Luneckaitė, Eimantas Peičius, Živilė Bagdonaitė, Olga Riklikienė, Edgaras Stankevičius
The prominence of biomedical criteria relying on brain death reduces the impact of metaphysical, anthropological, psychosocial, cultural, religious, and legal aspects disclosing the real value and essence of human life. The aim of this literature review is to discuss metaphysical and biomedical approaches toward death and their complimentary relationship in the determination of death. A critical appraisal of theoretical and scientific evidence and legal documents supported analytical discourse. In the metaphysical discourse of death, two main questions about what human death is and how to determine the fact of death clearly separate the ontological and epistemological aspects of death...
2016: Medicina
https://www.readbyqxmd.com/read/27625074/impact-of-religious-attendance-on-psychosocial-outcomes-for-individuals-with-traumatic-brain-injury-a-nidilrr-funded-tbi-model-systems-study
#17
Angela Philippus, David Mellick, Therese O'Neil-Pirozzi, Thomas Bergquist, Yelena Guller Bodien, Angelle M Sander, Laura E Dreer, Joseph Giacino, Thomas Novack
OBJECTIVES: To (1) identify demographic characteristics of individuals with traumatic brain injury (TBI) who attend religious services, (2) understand the relationship between attending religious services and psychosocial outcomes and (3) examine the independent contribution of religious service attendance to psychosocial outcomes while controlling for demographic characteristics, functional status and geographic location at 1, 5 and 10-years post injury. DESIGN: Retrospective, cross-sectional cohort study using secondary data analysis of the TBI Model Systems (TBIMS) National Database (NDB)...
2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27608678/ethiopian-teachers-their-knowledge-attitude-and-practice-towards-epilepsy
#18
Meron Awraris Gebrewold, Fikre Enquselassie, Redda Teklehaimanot, Seid Ali Gugssa
BACKGROUND: In Ethiopia where the burden of epilepsy is highest among school age children and teenagers, and where people with epilepsy (PWE) and their relatives suffers from high level of perceived stigma, there had not been any study that assessed the knowledge, attitude and practice of teachers towards PWE. This study aims to assess and understand the social and demographic determinants of knowledge, attitude and practice of teachers towards PLW in Addis Ababa, Ethiopia. METHODS: Multistage cluster sampling procedure was used to identify twenty schools from three sub cities of Addis Ababa, Ethiopia...
September 8, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27541016/when-brain-death-belies-belief
#19
Greg Yanke, Mohamed Y Rady, Joseph L Verheijde
The case of Jahi McMath has reignited a discussion concerning how society should define death. Despite pronouncing McMath brain dead based on the American Academy of Neurology criteria, the court ordered continued mechanical ventilation to accommodate the family's religious beliefs. Recent case law suggests that the potential for a successful challenge to the neurologic criteria of death provisions of the Uniform Determination of Death Act are greater than ever in the majority of states that have passed religious freedom legislation...
December 2016: Journal of Religion and Health
https://www.readbyqxmd.com/read/27539766/physicians-migration-perceptions-of-pakistani-medical-students
#20
Nazli Hossain, Nusrat Shah, Tahira Shah, Sidra Binte Lateef
OBJECTIVE: To study the perceptions of medical students about factors responsible for physicians'migration. STUDY DESIGN: Cross-sectional survey. PLACE AND DURATION OF STUDY: Dow Medical College and Civil Hospital, Karachi, from April to May 2015. METHODOLOGY: Aself-administered structured questionnaire was used including demographic details, attitudes about push and pull factors of migration, and reasons for migrating or not migrating abroad...
August 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
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