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https://www.readbyqxmd.com/read/28072809/optimal-angle-of-contralateral-oblique-view-in-cervical-interlaminar-epidural-injection-depending-on-the-needle-tip-position
#1
Jun Young Park, Myung-Hwan Karm, Doo Hwan Kim, Jae-Young Lee, Hye-Joo Yun, Jeong Hun Suh
BACKGROUND: Chronic neck and upper extremity pain associated with cervical origin is common, and cervical interlaminar epidural steroid injections (CILESIs) are frequently used to manage the symptoms of cervical spinal disorders. However, CILESIs are associated with risks such as dural puncture and cord injury. OBJECTIVES: We aimed to determine the optimal needle tip visualization, in order to minimize CILESIs-induced complications. STUDY DESIGN: Retrospective observational study...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28060757/line-1-hypomethylation-status-of-circulating-cell-free-dna-in-plasma-as-a-biomarker-for-colorectal-cancer
#2
Yuzo Nagai, Eiji Sunami, Yoko Yamamoto, Keisuke Hata, Satoshi Okada, Koji Murono, Koji Yasuda, Kensuke Otani, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Kazushige Kawai, Hiroaki Nozawa, Soichiro Ishihara, Dave S B Hoon, Toshiaki Watanabe
Colorectal cancer (CRC) is a serious public health problem and non-invasive biomarkers improving diagnosis or therapy are strongly required. Circulating cell-free DNA (cfDNA) has been a promising target for this purpose. In this study, we evaluated the potential of long interspersed nuclear element-1 (LINE-1) hypomethylation as a blood biomarker for CRC. LINE-1 hypomethylation level in plasma cfDNA in 114 CRC patients was retrospectively examined by absolute quantitative analysis of methylated alleles real-time PCR, and was expressed using LINE-1 hypomethylation index (LHI) [unmethylated copy number/ (methylated copy number + unmethylated copy number)]...
January 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28035987/tumor-line-1-methylation-level-in-association-with-survival-of-patients-with-stage-ii-colon-cancer
#3
Marloes Swets, Anniek Zaalberg, Arnoud Boot, Tom van Wezel, Martine A Frouws, Esther Bastiaannet, Hans Gelderblom, Cornelis J H van de Velde, Peter J K Kuppen
Genome-wide DNA hypomethylation is associated with a worse prognosis in early-stage colorectal cancer. To measure genome-wide DNA methylation levels, long interspersed nucleotide element (LINE-1) repeats are used as a surrogate marker. Cohort studies on the clinical impact of genome-wide DNA methylation level in patients with only early-stage colon cancer, are currently lacking. This study aimed to investigate the prognostic value of LINE-1 methylation in a stage II colon cancer cohort (n = 164). Manual needle microdissection of tumor areas was performed on formalin-fixed paraffin-embedded tumor tissue sections followed by DNA extraction...
December 27, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28024329/-n-m-assignments-of-metallic-single-walled-carbon-nanotubes-by-raman-spectroscopy-the-importance-of-electronic-raman-scattering
#4
Daqi Zhang, Juan Yang, Meihui Li, Yan Li
In this work, we report an accurate and convenient method that can be used to assign the chirality of all metallic single-walled carbon nanotubes (M-SWNTs). This method is designed based on the electronic Raman scattering (ERS) features, which are resonantly enhanced at the corresponding excitonic transition energies (Mii(+) and Mii(-)). Using this method, we are able to accurately determine the electronic property Mii with the resolution of a vibrational Raman spectroscopy (∼0.3 meV), which is significantly higher than that of the electronic spectroscopies (∼3 meV)...
December 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/28012829/l1-retrotransposition-alters-the-hippocampal-genomic-landscape-enabling-memory-formation
#5
Sara Bachiller, Yaiza Del-Pozo-Martín, Ángel Manuel Carrión
Somatic LINE-1 (L1) retrotransposition is a source of genomic mosaicism and potential phenotypic diversity among neurons during brain development. In the adult brain, L1 expression can be triggered by different environmental alterations, but its functional role in this context remains unknown. Here we demonstrate a neural activation-dependent increase in the number of L1 retrotransposon insertions in the hippocampus. Using both pharmacologic and genetic approaches in mice, we demonstrate that L1 expression in the adult hippocampus enables long-term memory formation...
December 21, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28003471/pirna-associated-proteins-and-retrotransposons-are-differentially-expressed-in-murine-testis-and-ovary-of-aryl-hydrocarbon-receptor-deficient-mice
#6
Eva M Rico-Leo, Nuria Moreno-Marín, Francisco J González-Rico, Eva Barrasa, Cristina Ortega-Ferrusola, Patricia Martín-Muñoz, Luis O Sánchez-Guardado, Elena Llano, Alberto Alvarez-Barrientos, Ascensión Infante-Campos, Inmaculada Catalina-Fernández, Matías Hidalgo-Sánchez, Dirk G de Rooij, Alberto M Pendás, Fernando J Peña, Jaime M Merino, Pedro M Fernández-Salguero
Previous studies suggested that the aryl hydrocarbon receptor (AhR) contributes to mice reproduction and fertility. However, the mechanisms involved remain mostly unknown. Retrotransposon silencing by Piwi-interacting RNAs (piRNAs) is essential for germ cell maturation and, remarkably, AhR has been identified as a regulator of murine B1-SINE retrotransposons. Here, using littermate AhR(+/+) and AhR(-/-) mice, we report that AhR regulates the general course of spermatogenesis and oogenesis by a mechanism likely to be associated with piRNA-associated proteins, piRNAs and retrotransposons...
December 2016: Open Biology
https://www.readbyqxmd.com/read/27996157/high-pesticide-exposure-events-and-dna-methylation-among-pesticide-applicators-in-the-agricultural-health-study
#7
Jennifer A Rusiecki, Laura E Beane Freeman, Matthew R Bonner, Melannie Alexander, Ligong Chen, Gabriella Andreotti, Kathryn H Barry, Lee E Moore, Hyang-Min Byun, Freya Kamel, Michael Alavanja, Jane A Hoppin, Andrea Baccarelli
Pesticide exposure has been associated with acute and chronic adverse health effects. DNA methylation (DNAm) may mediate these effects. We evaluated the association between experiencing unusually high pesticide exposure events (HPEEs) and DNAm among pesticide applicators in the Agricultural Health Study (AHS), a prospective study of applicators from Iowa and North Carolina. DNA was extracted from whole blood from male AHS pesticide applicators (n = 695). Questionnaire data were used to ascertain the occurrence of HPEEs over the participant's lifetime...
December 20, 2016: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/27986580/no-effect-of-different-bariatric-surgery-procedures-on-line-1-dna-methylation-in-diabetic-and-nondiabetic-morbidly-obese-patients
#8
G M Martín-Núñez, A Cabrera-Mulero, J Alcaide-Torres, E García-Fuentes, F J Tinahones, S Morcillo
BACKGROUND: Bariatric surgery (BS) is proposed as a highly effective therapy for reducing weight and improving obesity-related co-morbidities. The molecular mechanisms involved in the metabolic improvement after BS are not completely resolved. Epigenetic modifications could have an important role. OBJECTIVE: The aim of this study was to evaluate the effect of different BS procedures (Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy) on global DNA methylation (long interspersed nucleotide element 1 [LINE-1]) in a group of nondiabetic and diabetic severely obese patients...
October 21, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27986442/world-trade-center-wtc-dust-exposure-in-mice-is-associated-with-inflammation-oxidative-stress-and-epigenetic-changes-in-the-lung
#9
Vasanthi R Sunil, Kinal N Vayas, Mingzhu Fang, Helmut Zarbl, Christopher Massa, Andrew J Gow, Jessica A Cervelli, Howard Kipen, Robert J Laumbach, Paul J Lioy, Jeffrey D Laskin, Debra L Laskin
Exposure to World Trade Center (WTC) dust has been linked to respiratory disease in humans. In the present studies we developed a rodent model of WTC dust exposure to analyze lung oxidative stress and inflammation, with the goal of elucidating potential epigenetic mechanisms underlying these responses. Exposure of mice to WTC dust (20μg, i.t.) was associated with upregulation of heme oxygenase-1 and cyclooxygenase-2 within 3days, a response which persisted for at least 21days. Whereas matrix metalloproteinase was upregulated 7days post-WTC dust exposure, IL-6RA1 was increased at 21days; conversely, expression of mannose receptor, a scavenger receptor important in particle clearance, decreased...
December 13, 2016: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/27984135/epigenetic-regulation-of-placental-glucose-transporters-mediates-maternal-cadmium-induced-fetal-growth-restriction
#10
Peng Xu, Zhongqiang Wu, Yao Xi, Lan Wang
Cadmium (Cd) is one of the most toxic environmental pollutants that cause fetal malformation and growth restriction. However, the molecular mechanisms underlying maternal Cd toxicity on fetal growth remain largely unknown. Specifically, the role of placental nutrient transporters, including glucose transporters (GLUTs), has been poorly characterized in the etiology of Cd-induced fetal growth restriction (FGR). In the present study, we established a murine model of FGR induced by maternal Cd exposure, and examined the toxic effects of Cd on placental GLUTs...
October 27, 2016: Toxicology
https://www.readbyqxmd.com/read/27979589/in-vitro-hydroquinone-induced-instauration-of-histone-bivalent-mark-on-human-retroelements-line-1-in-hl60-cells
#11
Monica Mancini, Martina Mandruzzato, Alba C Garzia, Nora Sahnane, Elena Magnani, Filippo Macchi, Mustapha Oulad-Abdelghani, Pierre Oudet, Valentina Bollati, Silvia Fustinoni, Daniela Furlan, Ian M Bonapace
Benzene is extensively used in industry despite its leukemogenic activity, representing a significant occupational hazard. We investigated if long-term treatment with low-doses hydroquinone (HQ), a benzene metabolite, might be sufficient to alter in vitro the epigenetic signature underlining LINE-1 sequences, a poorly explored step in health risks associated with benzene exposure. In HL-60 cell line, exploring the epigenetic events occurring in chromatin, we found the transient instauration of the distinctive signature combining the repressive H3Lys27 tri-methylation mark and the activating H3Lys4 tri-methylation mark (H3K27me3/H3K4me3), indicating a tendency toward a poised chromatin conformation...
December 13, 2016: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/27965682/stable-epigenetic-variants-selected-from-an-induced-hypomethylated-fragaria-vesca-population
#12
Jihua Xu, Karen K Tanino, Stephen J Robinson
Epigenetic inheritance was transmitted through selection over five generations of extreme early, but not late flowering time phenotypic lines in Fragaria vesca. Epigenetic variation was initially artificially induced using the DNA demethylation reagent 5-azacytidine (5-azaC). It is the first report to explore epigenetic variant selection and phenotypic trait inheritance in strawberry. Transmission frequency of these traits was determined across generations. The early flowering (EF4) and late stolon (LS) phenotypic traits were successfully transmitted across five and three generations through meiosis, respectively...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27965292/engineered-line-1-retrotransposition-in-non-dividing-human-neurons
#13
Angela Macia, Thomas J Widmann, Sara R Heras, Veronica Ayllon, Laura Sanchez, Meriem Benkaddour-Boumzaouad, Martin Munoz-Lopez, Alejandro Rubio, Suyapa Amador-Cubero, Eva Blanco-Jimenez, Javier Garcia-Castro, Pablo Menendez, Philip Ng, Alysson R Muotri, John L Goodier, Jose L Garcia-Perez
Half of the human genome is made of Transposable Elements (TEs) whose ongoing activity continues to impact our genome. LINE-1 (or L1) is an autonomous non-LTR retrotransposon in the human genome, comprising 17% of its genomic mass and containing an average of 80-100 active L1s per average genome that provide a source of inter-individual variation. New LINE-1 insertions are thought to accumulate mostly during human embyogenesis. Surprisingly, the activity of L1s can further impact the somatic human brain genome...
December 13, 2016: Genome Research
https://www.readbyqxmd.com/read/27955637/prognostic-and-predictive-significance-of-long-interspersed-nucleotide-element-1-methylation-in-advanced-stage-colorectal-cancer
#14
Mami Kaneko, Masanori Kotake, Hiroyuki Bando, Tetsuji Yamada, Hirofumi Takemura, Toshinari Minamoto
BACKGROUND: Hypomethylation of Long Interspersed Nucleotide Element-1 (LINE-1) is associated with worse prognosis in colorectal cancer (CRC). However, little is known about the relevance of this marker for the prognosis and response to chemotherapy of metastatic and recurrent (advanced-stage) CRC. Our aim was therefore to investigate whether tumor LINE-1 hypomethylation correlates with patient survival and with response to 5-fluorouracil (5-FU)/ oxaliplatin (FOLFOX) chemotherapy in advanced-stage CRC...
December 12, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27940170/short-term-methionine-restriction-increases-hepatic-global-dna-methylation-in-adult-but-not-young-male-c57bl-6j-mice
#15
Dwight A L Mattocks, Samantha J Mentch, Jelena Shneyder, Gene P Ables, Dongxiao Sun, John P Richie, Jason W Locasale, Sailendra N Nichenametla
Despite well-documented evidence for lifespan extension by methionine restriction (MR), underlying mechanisms remain unknown. As methionine can alter S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH), the substrate and product of DNA methyltransferase-1 (DNMT1), we hypothesized that MR diet alters DNA methylation. Young (8-week-old) and adult (1-year-old) male C57BL/6J mice were fed diets with different levels of methionine (0.12%-MR, 0.84%-CD) for 12weeks. Functional indicators of DNA methylation, including global methylation (GM), gene-specific methylation (GSM) and LINE-1 methylation; and biochemical factors affecting DNA methylation, SAH, SAM, and DNMT1 were assessed in different tissues...
December 7, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27931521/epigenetic-regulation-of-placental-glucose-transporters-mediates-maternal-cadmium-induced-fetal-growth-restriction
#16
Peng Xu, Zhongqiang Wu, Yao Xi, Lan Wang
Cadmium (Cd) is one of the most toxic environmental pollutants that cause fetal malformation and growth restriction. However, the molecular mechanisms underlying maternal Cd toxicity on fetal growth remain largely unknown. Specifically, the role of placental nutrient transporters, including glucose transporters (GLUTs), has been poorly characterized in the etiology of Cd-induced fetal growth restriction (FGR). In the present study, we established a murine model of FGR induced by maternal Cd exposure, and examined the toxic effects of Cd on placental GLUTs...
November 30, 2016: Toxicology
https://www.readbyqxmd.com/read/27924165/assessment-of-global-dna-methylation-in-the-first-trimester-fetal-tissues-exposed-to-maternal-cigarette-smoking
#17
Svetlana Fa, Trine Vilsbøll Larsen, Katrine Bilde, Tina F Daugaard, Emil H Ernst, Rasmus H Olesen, Linn S Mamsen, Erik Ernst, Agnete Larsen, Anders L Nielsen
AIMS: Maternal cigarette smoking during pregnancy increases the risk of negative health consequences for the exposed child. Epigenetic mechanisms constitute a likely link between the prenatal exposure to maternal cigarette smoking and the increased risk in later life for diverse pathologies. Maternal smoking induces gene-specific DNA methylation alterations as well as global DNA hypermethylation in the term placentas and hypomethylation in the cord blood. Early pregnancy represents a developmental time where the fetal epigenome is remodeled and accordingly can be expected to be highly prone to exposures with an epigenetic impact...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27924012/l1base-2-more-retrotransposition-active-line-1s-more-mammalian-genomes
#18
Tobias Penzkofer, Marten Jäger, Marek Figlerowicz, Richard Badge, Stefan Mundlos, Peter N Robinson, Tomasz Zemojtel
LINE-1 (L1) insertions comprise as much as 17% of the human genome sequence, and similar proportions have been recorded for other mammalian species. Given the established role of L1 retrotransposons in shaping mammalian genomes, it becomes an important task to track and annotate the sources of this activity: full length elements, able to encode the cis and trans acting components of the retrotransposition machinery. The L1Base database (http://l1base.charite.de) contains annotated full-length sequences of LINE-1 transposons including putatively active L1s...
January 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27914298/effects-of-environmental-noise-exposure-on-dna-methylation-in-the-brain-and-metabolic-health
#19
Liqiong Guo, Peng-Hui Li, Hua Li, Elena Colicino, Silvia Colicino, Yi Wen, Ruiping Zhang, Xiaotian Feng, Timothy M Barrow, Akin Cayir, Andrea A Baccarelli, Hyang-Min Byun
Environmental noise exposure is associated with adverse effects on human health including hearing loss, heart disease, and changes in stress-related hormone levels. Alteration in DNA methylation in response to environmental exposures is a well-known phenomenon and it is implicated in many human diseases. Understanding how environmental noise exposures affect DNA methylation patterns may help to elucidate the link between noise and adverse effects on health. In this pilot study we examined the effects of environmental noise exposure on DNA methylation of genes related to brain function and investigated whether these changes are related with metabolic health...
November 30, 2016: Environmental Research
https://www.readbyqxmd.com/read/27910526/measurement-of-helium-like-and-hydrogen-like-argon-spectra-using-double-crystal-x-ray-spectrometers-on-east
#20
B Lyu, J Chen, R J Hu, F D Wang, Y Y Li, J Fu, Y C Shen, M Bitter, K W Hill, L F Delgado-Aparicio, N Pablant, S G Lee, M Y Ye, Y J Shi, B N Wan
A two-crystal assembly was deployed on the tangential X-ray crystal spectrometer to measure both helium-like and hydrogen-like spectra on EAST. High-quality helium-like and hydrogen-like spectra were observed simultaneously for the first time on one detector for a wide range of plasma parameters. Profiles of line-integrated core ion temperatures inferred from two spectra were consistent. Since tungsten was adopted as the upper divertor material, one tungsten line (W XLIV at 4.017 Å) on the short-wavelength side of the Lyman-α line (Lα1) was identified for typical USN discharges, which was diffracted by a He-like crystal (2d = 4...
November 2016: Review of Scientific Instruments
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