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https://www.readbyqxmd.com/read/28323572/bilateral-changes-in-deep-tissue-environment-after-manual-lymphatic-drainage-in-patients-with-breast-cancer-treatment-related-lymphedema
#1
Paula M C Donahue, Rachelle Crescenzi, Allison O Scott, Vaughn Braxton, Aditi Desai, Seth A Smith, John Jordi, Ingrid M Meszoely, Ana M Grau, Rondi M Kauffmann, Raeshell S Sweeting, Kandace Spotanski, Sheila H Ridner, Manus J Donahue
BACKGROUND: Breast cancer treatment-related lymphedema (BCRL) arises from a mechanical insufficiency following cancer therapies. Early BCRL detection and personalized intervention require an improved understanding of the physiological processes that initiate lymphatic impairment. Here, internal magnetic resonance imaging (MRI) measures of the tissue microenvironment were paired with clinical measures of tissue structure to test fundamental hypotheses regarding structural tissue and muscle changes after the commonly used therapeutic intervention of manual lymphatic drainage (MLD)...
March 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28319433/breast-reconstruction-following-nipple-sparing-mastectomy-clinical-outcomes-and-risk-factors-related-complications
#2
Rosaria Laporta, Benedetto Longo, Michail Sorotos, Alessio Farcomeni, Caterina Patti, Maria Rosaria Mastrangeli, Corrado Rubino, Fabio Santanelli di Pompeo
BACKGROUND: The aim of this study was to investigate clinical outcomes and risk factors related complications in patients who had undergone nipple-sparing mastectomy (NSM) followed by implant-based or autologous reconstruction. METHODS: Between 2004-2014 a single-institution retrospective review was collected on NSMs reconstruction. Patient demographics, comorbidities, breast morphological factors, type and timing of radiotherapy, type of incision, reconstruction type and timing, implant volume and complications were collected...
March 20, 2017: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/28319327/bilateral-breast-reconstruction-with-deep-inferior-epigastric-perforator-flaps-in-slim-patients
#3
Maria Mani, Samer Saour, Kelvin Ramsey, Kieran Power, Paul Harris, Stuart James
BACKGROUND: Slim women are not always considered candidates for bilateral autologous breast reconstruction. The study aims to assess the volume considerations and complications of deep inferior epigastric perforator (DIEP) flap in bilateral breast reconstruction among slim patients. METHODS: All patients undergoing bilateral DIEP breast reconstruction at the Royal Marsden Hospital, London, September 2007-March 2015, were reviewed. Flap weight was compared to mastectomy weight (weight ratio) and complications were recorded...
March 20, 2017: Microsurgery
https://www.readbyqxmd.com/read/28319069/the-branched-chain-amino-acid-transaminase-1-sustains-growth-of-antiestrogen-resistant-and-er%C3%AE-negative-breast-cancer
#4
V Thewes, R Simon, M Hlevnjak, M Schlotter, P Schroeter, K Schmidt, Y Wu, T Anzeneder, W Wang, P Windisch, M Kirchgäßner, N Melling, N Kneisel, R Büttner, U Deuschle, H P Sinn, A Schneeweiss, S Heck, S Kaulfuss, H Hess-Stumpp, J G Okun, G Sauter, A E Lykkesfeldt, M Zapatka, B Radlwimmer, P Lichter, M Tönjes
Antiestrogen-resistant and triple-negative breast tumors pose a serious clinical challenge because of limited treatment options. We assessed global gene expression changes in antiestrogen-sensitive compared with antiestrogen-resistant (two tamoxifen resistant and two fulvestrant resistant) MCF-7 breast cancer cell lines. The branched-chain amino acid transaminase 1 (BCAT1), which catalyzes the first step in the breakdown of branched-chain amino acids, was among the most upregulated transcripts in antiestrogen-resistant cells...
March 20, 2017: Oncogene
https://www.readbyqxmd.com/read/28303876/-ultrasonic-examination-of-the-breast-adipose-grafts-after-mammoplasty
#5
E P Fisenko, O I Startseva, D V Mel'nikov, A S Zakharenko, K A Kirillova, A G Ivanova, E D Pishchikova
AIM: To present the results of PRP-adipose grafts implanatation. MATERIAL AND METHODS: The study included 25 patients after transplantation of autologous adipose tissue. Autotransplantation was performed to correct volume defects of breast and to restore lost volume after polyacrylamide gel removal in 4 patients; after mastectomy in 6 cases; after complicated replacement using silicone endoprostheses in 11 patients; after previous reduction in 2 cases; after augmentation mammoplasty in 2 cases...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28301366/management-of-mastectomy-skin-necrosis-in-implant-based-breast-reconstruction
#6
Gloria R Sue, Chao Long, Gordon K Lee
BACKGROUND: Mastectomy skin necrosis is a significant problem after breast reconstruction. This complication may lead to poor wound healing and need for implant removal, which may delay subsequent oncologic treatment. We sought to characterize factors associated with mastectomy skin necrosis and propose a management algorithm. METHODS: A retrospective review was performed on consecutive patients undergoing implant-based breast reconstruction by the senior author from 2006 through 2015...
March 16, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28300372/lung-volume-reproducibility-under-abc-control-and-self-sustained-breath-holding
#7
Evangelia Kaza, Alex Dunlop, Rafal Panek, David J Collins, Matthew Orton, Richard Symonds-Tayler, Dualta McQuaid, Erica Scurr, Vibeke Hansen, Martin O Leach
An Active Breathing Coordinator (ABC) can be employed to induce breath-holds during CT imaging and radiotherapy of lung, breast and liver cancer, and recently during lung cancer MRI. The apparatus measures and controls respiratory volume, hence subject lung volume reproducibility is its principal measure of effectiveness. To assess ABC control quality, the intra-session reproducibility of ABC-induced lung volumes was evaluated and compared with that reached by applying the clinical standard of operator-guided self-sustained breath-holds on healthy volunteers during MRI...
March 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28298015/toward-the-complete-control-of-brain-metastases-using-surveillance-screening-and-stereotactic-radiosurgery
#8
Amparo Wolf, Svetlana Kvint, Abraham Chachoua, Anna Pavlick, Melissa Wilson, Bernadine Donahue, John G Golfinos, Joshua Silverman, Douglas Kondziolka
OBJECTIVE The incidence of brain metastases is increasing with improved systemic therapies, many of which have a limited impact on intracranial disease. Stereotactic radiosurgery (SRS) is a first-line management option for brain metastases. The purpose of this study was to determine if there is a threshold tumor size below which local control (LC) rates approach 100%, and to relate these findings to the use of routine surveillance brain imaging. METHODS From a prospective registry, 200 patients with 1237 brain metastases were identified who underwent SRS between December 2012 and May 2015...
February 17, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28297426/mri-geometric-distortion-impact-on-tangential-whole-breast-imrt
#9
Amy Walker, Peter Metcalfe, Gary Liney, Vikneswary Batumalai, Kylie Dundas, Carri Glide-Hurst, Geoff P Delaney, Miriam Boxer, Mei Ling Yap, Jason Dowling, David Rivest-Henault, Elise Pogson, Lois Holloway
The purpose of this study was to determine the impact of magnetic resonance imaging (MRI) geometric distortions when using MRI for target delineation and planning for whole-breast, intensity-modulated radiotherapy (IMRT). Residual system distortions and combined systematic and patient-induced distortions are considered. This retrospective study investigated 18 patients who underwent whole-breast external beam radiotherapy, where both CT and MRIs were acquired for treatment planning. Distortion phantoms were imaged on two MRI systems, dedicated to radiotherapy planning (a wide, closed-bore 3T and an open-bore 1T)...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297289/a-dosimetric-evaluation-of-knowledge-based-vmat-planning-with-simultaneous-integrated-boosting-for-rectal-cancer-patients
#10
Hao Wu, Fan Jiang, Haizhen Yue, Sha Li, Yibao Zhang
RapidPlan, a commercial knowledge-based optimizer, has been tested on head and neck, lung, esophageal, breast, liver, and prostate cancer patients. To appraise its performance on VMAT planning with simultaneous integrated boosting (SIB) for rectal cancer, this study configured a DVH (dose-volume histogram) estimation model consisting 80 best-effort manual cases of this type. Using the model- generated objectives, the MLC (multileaf collimator) sequences of other 70 clinically approved plans were reoptimized, while the remaining parameters, such as field geometry and photon energy, were maintained...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297275/how-dose-sparing-of-cardiac-structures-correlates-with-in-field-heart-volume-and-sternal-displacement
#11
Taeho Kim, Kelli Reardon, Daniel M Trifiletti, Constance Geesey, Kaitlyn Sukovich, Edwin Crandley, Paul W Read, Krishni Wijesooriya
Cardiac irradiation increases the risk of coronary artery disease in patients with left-sided breast cancer. Techniques exist to reduce cardiac irradiation, but the optimum technique depends on individual patient anatomy and physiology. We investigated the correlation of delta heart volume in field (dHVIF) and sternal excursion with dose sparing in heart and left anterior descending artery (LAD) to develop quantitative predictive models for expected dose to heart and LAD. A treatment planning study was performed on 97 left-breast cancer patients who underwent whole breast radiotherapy (prescription dose = 50 Gy) under deep inspiratory breath hold (DIBH)...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28295413/using-a-handheld-stereo-depth-camera-to-overcome-limited-field-of-view-in-simulation-imaging-for-radiation-therapy-treatment-planning
#12
Cesare Jenkins, Lei Xing, Amy Yu
PURPOSE: A correct body contour is essential for reliable treatment planning in radiation therapy. While modern medical imaging technologies provide highly accurate patient modeling, there are times when a patient's anatomy cannot be fully captured or there is a lack of easy access to computed tomography (CT) simulation. Here we provide a practical solution to the surface contour truncation problem by using a handheld stereo depth camera (HSDC) to obtain the missing surface anatomy and a surface-surface image registration to stich the surface data into the CT dataset for treatment planning...
March 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28295375/x-ray-scatter-correction-for-dedicated-cone-beam-breast-ct-using-a-forward-projection-model
#13
Linxi Shi, Srinivasan Vedantham, Andrew Karellas, Lei Zhu
PURPOSE: The quality of dedicated cone-beam breast CT (CBBCT) imaging is fundamentally limited by x-ray scatter contamination due to the large irradiation volume. In this paper, we propose a scatter correction method for CBBCT using a novel forward projection model with high correction efficacy and reliability. METHOD: We first coarsely segment the uncorrected, first-pass, reconstructed CBBCT images into binary-object maps and assign the segmented fibroglandular and adipose tissue with the correct attenuation coefficients based on the mean x-ray energy...
March 15, 2017: Medical Physics
https://www.readbyqxmd.com/read/28291926/development-of-a-deep-inspiration-breath-hold-system-for-radiotherapy-utilizing-a-laser-distance-measurer
#14
Christer Andre Jensen, Nils Skottner, Jomar Frengen, Jo-Åsmund Lund
Deep inspiration breath-hold (DIBH) is a technique for treating left-sided breast cancer (LSBC). In modern radiotherapy, one of the main aims is to exclude the heart from the beam aperture with an individualized beam design for LSBC. A deep inhalation will raise the chest wall while the volume of the lungs increase, this will again push the heart away from the breast to be treated. There are a few commercial DIBH systems, both invasive and noninvasive. We present an alternative noninvasive DIBH system based upon an industrial laser distance measurer...
January 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28290354/development-of-a-phantom-to-test-fully-automated-breast-density-software-a-work-in-progress
#15
G G Waade, S Hofvind, J D Thompson, R Highnam, P Hogg
OBJECTIVES: Mammographic density (MD) is an independent risk factor for breast cancer and may have a future role for stratified screening. Automated software can estimate MD but the relationship between breast thickness reduction and MD is not fully understood. Our aim is to develop a deformable breast phantom to assess automated density software and the impact of breast thickness reduction on MD. METHODS: Several different configurations of poly vinyl alcohol (PVAL) phantoms were created...
February 2017: Radiography
https://www.readbyqxmd.com/read/28289827/correlation-of-prediction-and-actual-outcome-of-three-dimensional-simulation-in-breast-augmentation-using-a-cloud-based-program
#16
Joshua Vorstenbosch, Avi Islur
BACKGROUND: Breast augmentation is among the most frequently performed cosmetic plastic surgeries. Providing patients with "realistic" 3D simulations of breast augmentation outcomes is becoming increasingly common. Until recently, such programs were costly and required significant equipment, training, and office space. New simple user-friendly cloud-based programs have been developed, but to date there remains a paucity of objective evidence comparing these 3D simulations with the post-operative outcomes...
March 13, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28287917/does-reader-performance-with-digital-breast-tomosynthesis-vary-according-to-experience-with-two-dimensional-mammography
#17
Lorraine Tucker, Fiona J Gilbert, Susan M Astley, Amanda Dibden, Archana Seth, Juliet Morel, Sara Bundred, Janet Litherland, Herman Klassen, Gerald Lip, Hema Purushothaman, Hilary M Dobson, Linda McClure, Philippa Skippage, Katherine Stoner, Caroline Kissin, Ursula Beetles, Yit Yoong Lim, Emma Hurley, Jane Goligher, Rumana Rahim, Tanja J Gagliardi, Tamara Suaris, Stephen W Duffy
Purpose To assess whether individual reader performance with digital breast tomosynthesis (DBT) and two-dimensional (2D) mammography varies with number of years of experience or volume of 2D mammograms read. Materials and Methods After written informed consent was obtained, 8869 women (age range, 29-85 years; mean age, 56 years) were recruited into the TOMMY trial (A Comparison of Tomosynthesis with Digital Mammography in the UK National Health Service Breast Screening Program), an ethically approved, multicenter, multireader, retrospective reading study, between July 2011 and March 2013...
March 13, 2017: Radiology
https://www.readbyqxmd.com/read/28281859/geometrical-uncertainty-of-heart-position-in-deep-inspiration-breath-hold-radiotherapy-of-left-sided-breast-cancer-patients
#18
Tuomas Koivumäki, Juuso Tujunen, Tuomas Virén, Janne Heikkilä, Jan Seppälä
BACKGROUND: This study aimed to determine the geometrical uncertainty of the position of the heart with daily cone beam computed tomography (CBCT) during deep-inspiration breath-hold (DIBH) treatment of the left breast. MATERIAL AND METHODS: A visually guided optical respiratory monitoring system was used in DIBH treatment of 15 breast cancer patients. Heart position was determined in relation to the planning target volume (PTV) in 225 fractions in which daily low-dose CBCT images were compared with planning CT images...
March 10, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28281052/interest-of-an-auto-adjustable-nighttime-compression-sleeve-mobiderm%C3%A2-autofit-in-maintenance-phase-of-upper-limb-lymphedema-the-marilyn-pilot-rct
#19
S Mestre, C Calais, G Gaillard, M Nou, M Pasqualini, C Ben Amor, I Quere
PURPOSE: Breast cancer-related lymphedema (BCRL) is a debilitating condition. The recommended treatment is based on decongestive lymphedema therapy (DLT) with two separate phases: a short-term intensive phase to reduce lymphedema volume and a long-term maintenance phase to stabilize it. Optimizing compression therapy and compliance during maintenance phase are key factors for long-term control of lymphedema. The primary objective of this pilot prospective open-label randomized study was to assess the benefit of a new auto-adjustable nighttime arm sleeve (MOBIDERM® Autofit) on lymphedema volume during the maintenance phase after the intensive phase...
March 9, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28280676/the-telemark-breast-score-a-valid-method-for-evaluation-of-outcome-after-breast-surgery
#20
Anadi Begic, Birgit Stark
BACKGROUND: "Telemark Breast Score" (TBS) has been developed at Telemark Hospital in Norway for evaluation of results after breast surgery based on standardized patients' photographs taken as a part of daily routine. Its reliability has recently been tested and approved. The external validity of the TBS was assessed by matching its data against the internationally recognized Breast-Q (BQ) questionnaire as a further step to study the validity of this new tool. METHODS: The ideal distribution of breast volume is 45% of the total volume above and 55% below the nipple, and a 40° slope line at the upper pole...
February 2017: Plastic and Reconstructive Surgery. Global Open
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