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https://www.readbyqxmd.com/read/28736788/characterisation-of-anticancer-peptides-at-the-single-cell-level
#1
L Armbrecht, G Gabernet, F Kurth, J A Hiss, G Schneider, P S Dittrich
The development of efficacious anticancer therapeutics is difficult due to the heterogeneity of the cellular response to chemotherapy. Anticancer peptides (ACPs) are promising drug candidates that have been shown to be active against a range of cancer cells. However, few ACP studies focus on tumour single-cell heterogeneities. In order to address this need, we developed a microfluidic device and an imaging procedure that enable the capture, monitoring, and analysis of several hundred single cells for the study of drug response...
July 24, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28735755/protective-effects-of-acute-exercise-prior-to-doxorubicin-on-cardiac-function-of-breast-cancer-patients-a-proof-of-concept-rct
#2
A A Kirkham, R E Shave, K A Bland, J M Bovard, N D Eves, K A Gelmon, D C McKenzie, S A Virani, E J Stöhr, D E R Warburton, K L Campbell
BACKGROUND: Preclinical studies have reported that a single treadmill session performed 24h prior to doxorubicin provides cardio-protection. We aimed to characterize the acute change in cardiac function following an initial doxorubicin treatment in humans and determine whether an exercise session performed 24h prior to treatment changes this response. METHODS: Breast cancer patients were randomized to either 30min of vigorous-intensity exercise 24h prior to the first doxorubicin treatment (n=13), or no vigorous exercise for 72h prior to treatment (control, n=11)...
July 14, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28734752/long-term-effect-of-oncoplastic-breast-conserving-surgery-using-latissimus-dorsi-miniflaps-on-mammographic-surveillance-and-the-detection-of-local-recurrence
#3
S Mele, D Wright, N Paramanathan, S Laws, L Peiris, R Rainsbury
INTRODUCTION: Latissimus dorsi miniflap is a breast-conserving volume replacement technique for the reconstruction of large breast defects. While mammographic features of miniflap reconstruction have been described, little is known about the incidence, mode of presentation and size of local recurrence after this procedure. This study aimed to investigate the impact of latissimus dorsi miniflap reconstruction on the frequency, presentation and detection of local recurrence. METHODS: Clinical, radiological and pathological data were reviewed in 261 patients...
June 28, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28734684/factors-influencing-list-prices-for-radiologists-services
#4
Andrew B Rosenkrantz, Wenyi Wang, Arvind Vijayasarathi, Richard Duszak
PURPOSE: To identify factors associated with list price variation for radiologists' services. METHODS: The 2014 Medicare Physician and Other Supplier Public Use File was used to identify submitted charges ("list prices") and payments for radiologists' services (ie, not hospital service charges). Charge-to-payment ratios were computed for individual radiologists as a measure of excess charges. Numerous radiologist-level factors identifiable using publicly available data sets were explored...
July 20, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28733879/anticancer-activity-of-salicin-and-fenofibrate
#5
Marwa Sabaa, Hassan M ELFayoumi, Shimaa Elshazly, Mahmoud Youns, Waleed Barakat
Cancer refers to a disorder of cell proliferation that leads to tumor production. Cancer is usually treated by surgery, chemotherapeutic drugs, and radiation. Despite the presence of many anticancer drugs, cancer is still an uncontrolled disease and is a major cause of death worldwide. In addition, most anticancer drugs have severe side effects that can limit their use in some patients. This study aims to investigate the possible anticancer activity of two clinically used drugs: a natural antioxidant agent (salicin) and an antihyperlipidemic agent (fenofibrate) against two breast cancer models (in vivo EAC and in vitro MCF7) and the pancreatic cancer cell line (Panc-1)...
July 21, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28731946/treatment-minimization-in-older-patients-with-early-stage-breast-cancer
#6
Tara M Hansen, Richard C Zellars
The management of early-stage breast cancer in older patients is complex and requires a careful balance of the risk of cancer death with the competing risks of comorbidities and treatment-related toxicity in women with largely favorable disease. As the US population continues to age, oncologists will increasingly encounter this clinical challenge. Several strategies involving each core component of breast cancer therapy have been investigated to minimize treatment in these patients while still maintaining acceptable outcomes...
July 2017: Cancer Journal
https://www.readbyqxmd.com/read/28730678/prognosis-following-cancer-surgery-during-holiday-periods
#7
Jesper Lagergren, Fredrik Mattsson, Pernilla Lagergren
Surgery is the mainstay curative treatment in most cancer. We aimed to test the new hypothesis that cancer surgery performed during holiday periods is associated with worse long-term prognosis than for non-holiday periods. This nationwide Swedish population-based cohort study included 228,927 patients during 1997-2014 who underwent elective resectional surgery for a cancer where the annual number of resections was over 100. The 16 eligible cancer sites were grouped into 10 cancer groups. The exposure, holiday periods, was classified as wide (14-weeks) or narrow (7-weeks)...
July 21, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28728326/the-role-of-negative-pressure-wound-therapy-in-latissimus-dorsi-flap-donor-site-seroma-prevention-a-cohort-study
#8
Apichai Angspatt, Thana Laopiyasakul, Pornthep Pungrasmi, Poonpissamai Suwajo
BACKGROUND: Donor site seroma is the most common complication after latissimus dorsi (LD) flap harvest. This study aimed to evaluate the efficacy of negative-pressure wound therapy (NPWT) in preventing donor site seroma formation after the harvest of an LD flap for breast reconstruction. METHODS: In this prospective matched-pair study, 40 patients in whom an LD flap was harvested for breast reconstruction were enrolled. NPWT was used in 20 patients, and in a control group composed of another 20 patients, the conventional donor site dressing technique was used...
July 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28725587/multi-parametric-mri-imaging-of-the-prostate-implications-for-focal-therapy
#9
REVIEW
James S Wysock, Herbert Lepor
The primary goal of a focal therapy treatment paradigm is to achieve cancer control through targeted tissue destruction while simultaneously limiting deleterious effects on peri-prostatic structures. Focal therapy approaches are employed in several oncologic treatment protocols, and have been shown to provide equivalent cancer control for malignancies such as breast cancer and renal cell carcinoma. Efforts to develop a focal therapy approach for prostate cancer have been challenged by several concepts including the multifocal nature of the disease and limited capability of prostate ultrasound and systematic biopsy to reliably localize the site(s) and aggressiveness of disease...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725257/study-protocol-an-investigation-of-mother-infant-signalling-during-breastfeeding-using-a-randomised-trial-to-test-the-effectiveness-of-breastfeeding-relaxation-therapy-on-maternal-psychological-state-breast-milk-production-and-infant-behaviour-and-growth
#10
N H M Shukri, J Wells, F Mukhtar, M H S Lee, M Fewtrell
BACKGROUND: The physiological and psychological signalling between mother and infant during lactation is one of the prominent mother-infant factors that may influence breastfeeding outcomes. The infant can 'signal' his needs through vocalisation, and the mother can respond by allowing or restricting nipple access, which might alter the breast milk composition or volume. This may lead to parent-offspring conflict during the lactation period. Challenging infant behaviour has also been associated with maternal psychological distress, which might affect breastfeeding performance...
2017: International Breastfeeding Journal
https://www.readbyqxmd.com/read/28724908/design-and-discovery-of-novel-monastrol-1-3-5-triazines-as-potent-anti-breast-cancer-agent-via-attenuating-epidermal-growth-factor-receptor-tyrosine-kinase
#11
Jitendra Kumar Srivastava, Girinath G Pillai, Hans Raj Bhat, Amita Verma, Udaya Pratap Singh
A novel series of hybrid analogues of monastrol-1,3,5-triazine were designed and developed via one-pot synthesis using Bi(NO3)3 as a catalyst. Entire compounds were evaluated for their anticancer activity against HeLa (cervical cancer), MCF-7 (breast cancer), HL-60 (Human promyelocytic leukemia), HepG2 (Hepatocellular carcinoma) and MCF 12A (normal epithelial breast cell line) using MTT assay, where they showed highest inhibitory activity against MCF-7. The molecules were also found to be non-toxic to MCF 12A cells...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724133/a-nationwide-analysis-of-cost-variation-for-autologous-free-flap-breast-reconstruction
#12
Jessica I Billig, Yiwen Lu, Adeyiza O Momoh, Kevin C Chung
Importance: Cost variation among hospitals has been demonstrated for surgical procedures. Uncovering these differences has helped guide measures taken to reduce health care spending. To date, the fiscal consequence of hospital variation for autologous free flap breast reconstruction is unknown. Objective: To investigate factors that influence cost variation for autologous free flap breast reconstruction. Design, Setting, and Participants: A secondary cross-sectional analysis was performed using the Healthcare Cost and Utilization Project National Inpatient Sample database from 2008 to 2010...
July 19, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28721885/nrg-oncology-radiation-therapy-oncology-group-study-1014-1-year-toxicity-report-from-a-phase-2-study-of-repeat-breast-preserving-surgery-and-3-dimensional-conformal-partial-breast-reirradiation-for-in-breast-recurrence
#13
Douglas W Arthur, Kathryn A Winter, Henry M Kuerer, Bruce G Haffty, Laurie W Cuttino, Dorin A Todor, Nicole L Simone, Shelly B Hayes, Wendy A Woodward, Beryl McCormick, Randi J Cohen, Walter M Sahijdak, Daniel J Canaday, Doris R Brown, Adam D Currey, Christine M Fisher, Reshma Jagsi, Julia White
PURPOSE: To determine the associated toxicity, tolerance, and safety of partial-breast reirradiation. METHODS AND MATERIALS: Eligibility criteria included in-breast recurrence occurring >1 year after whole-breast irradiation, <3 cm, unifocal, and resected with negative margins. Partial-breast reirradiation was targeted to the surgical cavity plus 1.5 cm; a prescription dose of 45 Gy in 1.5 Gy twice daily for 30 treatments was used. The primary objective was to evaluate the rate of grade ≥3 treatment-related skin, fibrosis, and/or breast pain adverse events (AEs), occurring ≤1 year from re-treatment completion...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28719946/cell-assisted-lipotransfer-friend-or-foe-in-fat-grafting-systematic-review-and-meta-analysis
#14
REVIEW
J Laloze, A Varin, J Gilhodes, N Bertheuil, J L Grolleau, J Brie, J Usseglio, L Sensebe, T Filleron, B Chaput
BACKGROUND: Autologous fat grafting is a common procedure for soft-tissue reconstruction but is associated with a graft resorption rate ranging from 20% to 80%. To improve the fat graft survival rate, a new technique, called cell-assisted lipotransfer (CAL), was developed. With CAL, fat is injected along with adipose-derived stromal cells (ASCs) that are assumed to improve fat survival rate. We conducted an evidence-based meta-analysis to evaluate the efficacy and safety of CAL as compared with conventional autologous fat grafting (non-CAL)...
July 18, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28717826/operator-radiation-exposure-during-transradial-coronary-angiography-effect-of-single-vs-double-catheters
#15
A Tarighatnia, L Pourafkari, A Farajollahi, A H Mohammadalian, M Ghojazadeh, N D Nader
BACKGROUND: The right radial artery has gained popularity as the preferred access site for coronary angiography. To save time and limit the radiation exposure of operators and patients, newly designed catheters can be used to access both the right and left coronary arteries. The aim of this study was to compare operator radiation exposure between single-catheter (SCA) and two-catheter approaches (TCA). METHODS: In all, 256 patients undergoing diagnostic coronary angiography via the right radial artery in a high-volume medical center were randomized to either the SCA or TCA group...
July 17, 2017: Herz
https://www.readbyqxmd.com/read/28717404/physical-activity-does-not-alter-prolactin-levels-in-post-menopausal-women-results-from-a-dose-response-randomized-controlled-trial
#16
Darren R Brenner, Yibing Ruan, Andria R Morielli, Kerry S Courneya, Christine M Friedenreich
BACKGROUND: Increased circulating levels of prolactin have been associated with increased risk of both in situ and invasive breast cancer. We investigated whether or not physical activity had a dose-response effect in lowering plasma levels of prolactin in postmenopausal women. METHODS: Four hundred previously inactive but healthy postmenopausal women aged 50-74 years of age were randomized to 150 or 300 min per week of aerobic physical activity in a year-long intervention...
2017: European Review of Aging and Physical Activity
https://www.readbyqxmd.com/read/28716678/cancer-recurrence-monitoring-using-hyperpolarized-1-13-c-pyruvate-metabolic-imaging-in-murine-breast-cancer-model
#17
Peter J Shin, Zihan Zhu, Roman Camarda, Robert A Bok, Alicia Y Zhou, John Kurhanewicz, Andrei Goga, Daniel B Vigneron
The purpose of this work was to study the anatomic and metabolic changes that occur with tumor progression, regression and recurrence in a switchable MYC-driven murine breast cancer model. Serial (1)H MRI and hyperpolarized [1-(13)C]pyruvate metabolic imaging were used to investigate the changes in tumor volume and glycolytic metabolism over time during the multistage tumorigenesis. We show that acute de-induction of MYC expression in established tumors results in rapid tumor regression and significantly reduced glycolytic metabolism as measured by pyruvate-to-lactate conversion...
July 14, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28715130/average-glandular-dose-coefficients-for-pendant-geometry-breast-ct-using-realistic-breast-phantoms
#18
Andrew M Hernandez, John M Boone
PURPOSE: To design volume-specific breast phantoms from breast CT (bCT) data sets and estimate the associated normalized mean glandular dose coefficients for breast CT using Monte Carlo methods. METHODS: A large cohort of bCT data sets (N=215) was used to evaluate breast volume into quintiles (plus the top 5%). The average radius profile was then determined for each of the six volume-specific groups and used to both fabricate physical phantoms and generate mathematical phantoms (V1-V6; "V" denotes classification by volume)...
July 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28712278/in-vivo-dosimetry-and-acute-toxicity-in-breast-cancer-patients-undergoing-intraoperative-radiotherapy-as-boost
#19
Jason Joon Bock Lee, Jinhyun Choi, Sung Gwe Ahn, Joon Jeong, Ik Jae Lee, Kwangwoo Park, Kangpyo Kim, Jun Won Kim
PURPOSE: To report the results of a correlation analysis of skin dose assessed by in vivo dosimetry and the incidence of acute toxicity. This is a phase 2 trial evaluating the feasibility of intraoperative radiotherapy (IORT) as a boost for breast cancer patients. MATERIALS AND METHODS: Eligible patients were treated with IORT of 20 Gy followed by whole breast irradiation (WBI) of 46 Gy. A total of 55 patients with a minimum follow-up of 1 month after WBI were evaluated...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28709454/comparison-of-skin-sparing-mastectomy-using-ligasure%C3%A2-small-jaw-and-electrocautery
#20
Young Woo Chang, Hwan Soo Kim, Seung Pil Jung, Sang Uk Woo, Jae Bok Lee, Jeoung Won Bae, Gil Soo Son
BACKGROUND: Skin-sparing mastectomy (SSM) is increasingly used in patients with breast cancer. We compared the differences between use of electrocautery and LigaSure™ Small Jaw in patients with breast cancer who underwent SSM. METHODS: Between January 2012 and December 2015, 81 patients with breast cancer who underwent SSM were selected and were divided into the electrocautery group and the LigaSure™ Small Jaw group based on the devices that were used. Clinicopathological characteristics, body mass index, operative time, and weight of removed breast were obtained from medical records...
July 14, 2017: World Journal of Surgical Oncology
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