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https://www.readbyqxmd.com/read/29341018/magnetic-resonance-spectroscopy-studies-of-mouse-models-of-cancer
#1
Menglin Cheng, Kristine Glunde
Magnetic resonance spectroscopy (MRS) or spectroscopic imaging (MRSI) enables the detection of metabolites, amino acids, and lipids, among other biomolecules, in tumors of live mouse models of cancer. Tumor-bearing mice are anesthetized by breathing isoflurane in a magnetic resonance (MR) scanner dedicated to small animal MR. Here we describe the overall setup and steps for measuring 1H and 31P MRS and 1H MRSI of orthotopic breast tumor models in mice with surface coils. This protocol can be adapted to the use of volume coils to measure 1H and 31P MRS(I) of tumor models that grow inside the body...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29340749/in-pursuit-of-effective-volume-reduction-and-enhanced-aesthetics-for-treatment-of-gigantomastia-using-superior-dermoglandular-pedicle
#2
Betul Gozel Ulusal, Ince Alper
BACKGROUND: Gigantomastia is defined as extreme hypertrophy of the female breast. It is a disabling condition that presents unique challenges to plastic surgeons. Initial breast volume is an important factor affecting the success of the reduction. Usually, it is difficult to achieve small-sized breasts, and long-term results are often unsatisfactory, resulting in complications such as "bottoming-out" deformities. METHODS: This paper presents a case series involving 40 patients (mean age 44...
January 16, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29339047/the-impact-of-semilateral-decubitus-position-on-the-dose-volume-parameters-of-the-heart-and-lung-for-left-sided-breast-cancer-patients-a-comparative-dosimetric-study
#3
Azza Helal, Mohamed Farouk, Sherief H Gamie, Mahran Abdo, Lila Mosa, Amr Abdul Aziz
PURPOSE: When treating breast cancer with radiation therapy, the impact of treatment position on heart and lung dose-volume parameters (DVPs) is largely dependent on the maximal heart distance (MHD) and central lung distance (CLD). We evaluate how much heart and lung sparing can be achieved using the semilateral decubitus (SLD) position without and with breath hold compared with the standard supine position for left-sided breast cancer patients. A secondary aim was to investigate the impact of MHD and CLD on heart and lung DVPs...
December 2, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29338639/is-continuous-passive-motion-effective-in-patients-with-lymphedema-a-randomized-controlled-trial
#4
Ramazan Kizil, Banu Dilek, Ebru Şahin, Onur Engin, Ali Can Soylu, Elif Akalin, Serap Alper
BACKGROUND: In this randomized controlled study, we aimed to evaluate the effect of shoulder flexion exercise using continuous passive motion (CPM) on lymphedema during the treatment of breast cancer-related lymphedema (BCRL). METHODS: Thirty patients with BCRL were enrolled and completed the study. Fourteen patients were treated with complete decongestive therapy (CDT) and CPM in the intervention group, and 16 patients were treated with CDT alone (control group) for 15 sessions...
January 17, 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29338541/diagnostic-accuracy-of-clinical-measures-considering-segmental-tissue-composition-and-volume-changes-of-breast-cancer-related-lymphedema
#5
Eun Joo Yang, Seoung Yeon Kim, Woo Hyung Lee, Jae-Young Lim, Jaebong Lee
BACKGROUND: If we use only volumetry for measuring lymphedema, we could underdiagnose lymphedema with characteristics of biomechanical changes without definite volume change, especially in the medial forearm. METHODS AND RESULTS: In total, 158 breast cancer patients participated in this study. Arm volume was measured by water displacement volumetry, and segmental volumes were calculated from circumferences by using the truncated cone method. Subcutaneous ultrasound echogenicities were assessed on the medial side of the upper arm and forearm of both arms and graded by subcutaneous echogenicity grade (SEG) and revised SEG (rSEG)...
January 17, 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29338090/influence-of-provider-factors-and-race-on-uptake-of-breast-cancer-gene-expression-profiling
#6
Katherine E Reeder-Hayes, Stephanie B Wheeler, Christopher D Baggett, Xi Zhou, Ke Meng, Megan C Roberts, Lisa A Carey, Anne-Marie Meyer
BACKGROUND: Gene expression profiling (GEP) has been rapidly adopted for early breast cancer and can aid in chemotherapy decision making. Study results regarding racial disparities in testing are conflicting, and may reflect different care settings. To the authors' knowledge, data regarding the influence of provider factors on testing are scarce. METHODS: The authors used a statewide, multipayer, insurance claims database linked to cancer registry records to examine the impact of race and provider characteristics on GEP uptake in a cohort of patients newly diagnosed with breast cancer between 2005 and 2012...
January 16, 2018: Cancer
https://www.readbyqxmd.com/read/29337068/the-impact-of-compression-force-and-pressure-at-prevalent-screening-on-subsequent-re-attendance-in-a-national-screening-program
#7
Nataliia Moshina, Sofie Sebuødegård, Åsne S Holen, Gunvor G Waade, Kaitlyn Tsuruda, Solveig Hofvind
Adherence to screening may indirectly help assess whether a prior screening examination deters women from returning for a subsequent examination. We investigated whether compression force and pressure in mammography were associated with re-attendance among prevalently screened women in the organized breast cancer screening program in BLINDED. Data on compression force (kg) and pressure (kPa) from women's first screening examination in the program (prevalent screening) and subsequent re-attendance were available for 31,225 women aged 50-68, screened during 2007-2013...
January 11, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29334788/latissimus-dorsi-flap-in-breast-reconstruction-recent-innovations-in-the-workhorse-flap
#8
Rachita Sood, Jeena M Easow, Geoffrey Konopka, Zubin J Panthaki
BACKGROUND: Surgeons employ the latissimus dorsi flap (LDF) for reconstruction of a large variety of breast cancer surgery defects, including quadrantectomy, lumpectomy, modified radical mastectomy, and others. The LDF may be used in delayed or immediate reconstruction, in combination with tissue expanders for a staged reconstruction, with implant-based immediate reconstruction, or alone as an autogenous flap. METHODS: The authors discuss the historical uses and more recent developments in the LDF...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29333462/assessment-of-ultrasound-radio-guided-occult-lesion-localization-in-non-palpable-breast-lesions
#9
Seyed Ali Alamdaran, Donia Farokh, Ayda Sharifi Haddad, Navid Daghighi, Elaheh Modoodi, Ramin Sadeghi, Mohammad Naser Forghani, Asieh Sadat Fattahi
Objectives: Controversy exists about the localization of non-palpable breast lesions. In many countries, the gold standard for the diagnosis of these lesions is needle localization due to its accuracy. This study sought to compare the ultrasound- and radio-guided occult lesion localization (ROLL) as a simple method with the conventional procedures in terms of their diagnostic power. Methods: This study was conducted on 94 patients with non-palpable breast lesions detected by ultrasonography and localized by the combination of ultrasonography and using radiopharmaceuticals...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29333084/effects-of-%C3%AE-mangostin-on-viability-growth-and-cohesion-of-multicellular-spheroids-derived-from-human-breast-cancer-cell-lines
#10
Giuseppe Scolamiero, Claudia Pazzini, Francesca Bonafè, Carlo Guarnieri, Claudio Muscari
Background: α-Mangostin (αMG) is extracted from Garcinia mangostana Linn and exerts antiproliferative activities. Although several researches on αMG were performed using cell monolayers, the in vitro pharmacological effects on 3D cancer models have never been investigated. Aim of the present study was to find new anticancer properties of αMG by evaluating the changes that this compound provokes in multicellular tumour spheroids (MCTSs). Methods: MCTSs were generated from MDA-MB-231 and MCF-7 breast tumour cell lines and then treated with 0...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29328875/environmental-determinants-of-breast-cancer
#11
Robert A Hiatt, Julia Green Brody
In the United States, breast cancer is the most common invasive malignancy and the second most common cause of death from cancer in women. Reproductive factors, estrogen, and progesterone have major causal roles, but concerns about other potential causes in the external environment continue to drive research inquiries and stimulate calls for action at the policy level. The environment is defined as anything that is not genetic and includes social, built, and chemical toxicant aspects. This review covers the scope of known and suspected environmental factors that have been associated with breast cancer and illustrates how epidemiology, toxicology, and mechanistic studies work together to create the full picture of environmental effects on this malignancy...
January 12, 2018: Annual Review of Public Health
https://www.readbyqxmd.com/read/29327648/the-goniometer-device-special-equipment-designed-for-symmetric-mammoplasty-planning-and-photo-symmetry-analysis-technique
#12
Tahsin Görgülü
INTRODUCTION: Preoperative planning is an essential prerequisite for the success of plastic surgery. In procedures such as breast reduction, freehand drawings may be associated with a number of challenges during the determination of axes vertical and parallel to the surgical site. Furthermore, many procedures involve subjective maneuvers, such as attempts aimed at positioning both nipples on the same line and transferring nipple-areola complexes in a well-matched manner. Our newly designed instrument, that is, the goniometer (TG), aims to ensure metric measurements appropriate for the axes, and it may also be used in circumstances that require angle measurements...
January 1, 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29323210/anticancer-potentiality-of-lignan-rich-fraction-of-six-flaxseed-cultivars
#13
Shahira M Ezzat, Samia A Shouman, Abeer Elkhoely, Yasmin M Attia, Mohamed S Elsesy, Amira S El Senousy, Mouchira A Choucry, Sabah H El Gayed, Abeer A El Sayed, Essam Abdel Sattar, Nebal El Tanbouly
The objective of our study is to highlight the therapeutic effect and mechanism of action by which purified Flaxseed hydrolysate (PFH) which is a lignan rich fraction exerts its anticancer activity on a human breast cancer cell line (T47D) and in mice bearing tumor. HPLC analysis of PFH of six flaxseed cultivars had shown that PFH of the cultivar Giza 9 (PFH-G9) contains the highest concentration of SDG (81.64 mg/g). The in vitro cytotoxic potentiality of PFH's of six flaxseed cultivars was screened against a panel of human cancer cell lines...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29320532/automatic-outer-and-inner-breast-tissue-segmentation-using-multi-parametric-mri-images-of-breast-tumor-patients
#14
Snekha Thakran, Subhajit Chatterjee, Meenakshi Singhal, Rakesh Kumar Gupta, Anup Singh
The objectives of the study were to develop a framework for automatic outer and inner breast tissue segmentation using multi-parametric MRI images of the breast tumor patients; and to perform breast density and tumor tissue analysis. MRI of the breast was performed on 30 patients at 3T-MRI. T1, T2 and PD-weighted(W) images, with and without fat saturation(WWFS), and dynamic-contrast-enhanced(DCE)-MRI data were acquired. The proposed automatic segmentation approach was performed in two steps. In step-1, outer segmentation of breast tissue from rest of body parts was performed on structural images (T2-W/T1-W/PD-W without fat saturation images) using automatic landmarks detection technique based on operations like profile screening, Otsu thresholding, morphological operations and empirical observation...
2018: PloS One
https://www.readbyqxmd.com/read/29315172/fertility-preservation-services-for-women-with-newly-diagnosed-cancer-a-national-assessment
#15
William D Winkelman, Mitchell P Rosen, Evelyn Mok-Lin
OBJECTIVE: To study the resources available for cancer patients once referred for fertility preservation. MATERIALS AND METHODS: Cross-sectional study clinics that are members of the Society for Assisted Reproductive Technology assess support for fertility preservation. RESULTS: Surveys were distributed to a total of 1135 members at 394 Society for Assisted Reproductive Technology clinics. Responses were received from 99 individuals representing a total of 84 unique clinics (21...
January 8, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29311580/lsd1-activation-promotes-inducible-emt-programs-and-modulates-the-tumour-microenvironment-in-breast-cancer
#16
T Boulding, R D McCuaig, A Tan, K Hardy, F Wu, J Dunn, M Kalimutho, C R Sutton, J K Forwood, A G Bert, G J Goodall, L Malik, D Yip, J E Dahlstrom, A Zafar, K K Khanna, S Rao
Complex regulatory networks control epithelial-to-mesenchymal transition (EMT) but the underlying epigenetic control is poorly understood. Lysine-specific demethylase 1 (LSD1) is a key histone demethylase that alters the epigenetic landscape. Here we explored the role of LSD1 in global epigenetic regulation of EMT, cancer stem cells (CSCs), the tumour microenvironment, and therapeutic resistance in breast cancer. LSD1 induced pan-genomic gene expression in networks implicated in EMT and selectively elicits gene expression programs in CSCs whilst repressing non-CSC programs...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29311051/relationship-between-state-level-google-online-search-volume-and-cancer-incidence-in-the-united-states-retrospective-study
#17
Charles A Phillips, Allison Barz Leahy, Yimei Li, Marilyn M Schapira, L Charles Bailey, Raina M Merchant
BACKGROUND: In the United States, cancer is common, with high morbidity and mortality; cancer incidence varies between states. Online searches reflect public awareness, which could be driven by the underlying regional cancer epidemiology. OBJECTIVE: The objective of our study was to characterize the relationship between cancer incidence and online Google search volumes in the United States for 6 common cancers. A secondary objective was to evaluate the association of search activity with cancer-related public events and celebrity news coverage...
January 8, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29303067/modified-tumescent-solution-for-creating-working-space-during-endoscopic-thyroidectomy
#18
Li-Yong Zhang, Wen-Xin Zhao, Bo Wang, Shou-Yi Yan, Jia Wen
OBJECTIVE: To study the feasibility of gas-liquid mixing tumescent solution for creating a working space (WS) in endoscopic thyroidectomy (ET). MATERIALS AND METHODS: A prospective study was performed on 186 patients with thyroid tumor who had undergone ET via chest and breast approach. Patients were randomly divided into 2 groups to receive traditional tumescent solution as group A and modified tumescent solution (gas-liquid mixing tumescent solution) as group B...
January 1, 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29302732/the-effects-of-platelet-rich-plasma-and-adipose-derived-stem-cells-on-neovascularization-and-fat-graft-survival
#19
Bing-Jun Xiong, Qiu-Wen Tan, Yu-Juan Chen, Yi Zhang, Di Zhang, Shen-Li Tang, Shu Zhang, Qing Lv
BACKGROUND: Adipose-derived stem cell (ADSCs)-assisted and platelet-rich plasma (PRP)-assisted lipofilling aim to enhance angiogenesis and cell proliferation and are promising techniques for lipofilling. This study aimed to compare the outcomes of ADSCs-assisted and PRP-assisted lipofilling. METHODS: Adipose tissue and human venous blood were obtained from women with early breast cancer. Human ADSCs were isolated and amplified in vitro. PRP was extracted through double centrifugation...
January 4, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29302500/erratum-to-immediate-breast-volume-replacement-using-a-free-dermal-fat-graft-after-breast-cancer-surgery-multi-institutional-joint-research-of-short-term-outcomes-in-262-japanese-patients
#20
Yuko Kijima, Chihaya Koriyama, Teruhiko Fujii, Kouichi Hirokaga, Kiyoshi Ishigure, Tomoyo Kaneko, Shuji Kayano, Sachio Miyamoto, Yasuaki Sagara, Takashi Sakurai, Teruhisa Sakurai, Keiichi Sotome, Hiroaki Ueo, Kazuyuki Wakita, Masahiro Watatani
[This corrects the article on p. 179 in vol. 4, PMID: 26005649.].
December 2017: Gland Surgery
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