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https://www.readbyqxmd.com/read/27884381/elevated-adiponectin-but-varied-response-in-circulating-leptin-levels-to-falciparum-malaria-in-type-2-diabetics-and-non-diabetic-controls
#1
COMMENT
Samuel Acquah, Benjamin Ackon Eghan, Johnson Nyarko Boampong
BACKGROUND: To investigate effects of falciparum malaria on circulating levels of leptin and adiponectin in type 2 diabetes mellitus (T2DM) and non-diabetic controls in relation to measures of adiposity. METHODS: Levels of leptin and adiponectin were measured in 100 type 2 diabetics and 100 age-matched controls before and during falciparum malaria in a 2-year prospective study. Also, waist circumference (WC), weight, height and hip circumference were measured. Body mass index (BMI) and waist-to-hip ratio (WHR) were computed...
October 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27875539/secular-trends-in-admissions-and-mortality-rates-from-diabetes-mellitus-in-the-central-belt-of-ghana-a-31-year-review
#2
Osei Sarfo-Kantanka, Fred Stephen Sarfo, Eunice Oparebea Ansah, Benjamin Eghan, Nana Kwame Ayisi-Boateng, Emmanuel Acheamfour-Akowuah
INTRODUCTION: Diabetes Mellitus is currently a leading cause of morbidity and mortality throughout the world, particularly in sub-Saharan Africa where a significant proportion of diabetes cases are now found. Longitudinal profiling of in-patient admissions and mortality trends from diabetes provide useful insights into the magnitude of the burden of diabetes, serve as a sentinel on the state of out-patient diabetes care and provide effective tools for planning, delivering and evaluating the health care needs relating to the disease in sub-Saharan Africa...
2016: PloS One
https://www.readbyqxmd.com/read/27303364/impact-of-type-2-diabetes-on-impaired-kidney-function-in-sub-saharan-african-populations
#3
Sally N Adebamowo, Adebowale A Adeyemo, Fasil Tekola-Ayele, Ayo P Doumatey, Amy R Bentley, Guanjie Chen, Jie Zhou, Daniel Shriner, Olufemi Adetola Fasanmade, Godfrey Okafor, Benjamin Eghan, Kofi Agyenim-Boateng, Jokotade Adeleye, Williams Balogun, Albert G Amoah, Samuel Owusu, Joseph Acheampong, Thomas Johnson, Johnnie Oli, Clement A Adebamowo, Charles N Rotimi
BACKGROUND: Diabetes is a leading risk factor for impaired kidney function, an indicator of chronic kidney disease. The aim of this study was to examine the association between type 2 diabetes (T2D) and impaired kidney function among adults in sub-Saharan Africa (SSA). METHODS: Participants were enrolled from Ghana, Kenya, and Nigeria. Impaired kidney function was based on an estimated glomerular filtration rate <60 ml/min/1.73 m(2). Using logistic regression models, we conducted case-control analyses to estimate the multivariate-adjusted association of T2D and kidney function...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27298824/increased-oxidative-stress-and-inflammation-independent-of-body-adiposity-in-diabetic-and-nondiabetic-controls-in-falciparum-malaria
#4
Samuel Acquah, Johnson Nyarko Boampong, Benjamin Ackon Eghan Jnr
Information on the extent to which oxidative stress and inflammation occur in the presence of falciparum malaria and type 2 diabetes mellitus in the same individual is limited. This study sought to investigate the extent of inflammation and oxidative stress in adult uncomplicated malaria by measuring fasting levels of lipid peroxides, C-reactive protein (CRP), and total antioxidant power (TAP) before and during falciparum malaria, in 100 respondents with type 2 diabetes and 100 age-matched controls in the Cape Coast metropolis of Ghana...
2016: BioMed Research International
https://www.readbyqxmd.com/read/26635871/evaluation-of-genome-wide-association-study-associated-type-2-diabetes-susceptibility-loci-in-sub-saharan-africans
#5
Adebowale A Adeyemo, Fasil Tekola-Ayele, Ayo P Doumatey, Amy R Bentley, Guanjie Chen, Hanxia Huang, Jie Zhou, Daniel Shriner, Olufemi Fasanmade, Godfrey Okafor, Benjamin Eghan, Kofi Agyenim-Boateng, Jokotade Adeleye, Williams Balogun, Abdel Elkahloun, Settara Chandrasekharappa, Samuel Owusu, Albert Amoah, Joseph Acheampong, Thomas Johnson, Johnnie Oli, Clement Adebamowo, Francis Collins, Georgia Dunston, Charles N Rotimi
Genome wide association studies (GWAS) for type 2 diabetes (T2D) undertaken in European and Asian ancestry populations have yielded dozens of robustly associated loci. However, the genomics of T2D remains largely understudied in sub-Saharan Africa (SSA), where rates of T2D are increasing dramatically and where the environmental background is quite different than in these previous studies. Here, we evaluate 106 reported T2D GWAS loci in continental Africans. We tested each of these SNPs, and SNPs in linkage disequilibrium (LD) with these index SNPs, for an association with T2D in order to assess transferability and to fine map the loci leveraging the generally reduced LD of African genomes...
2015: Frontiers in Genetics
https://www.readbyqxmd.com/read/25587486/evidence-of-insulin-resistance-in-adult-uncomplicated-malaria-result-of-a-two-year-prospective-study
#6
Samuel Acquah, Johnson Nyarko Boampong, Benjamin Ackon Eghan Jnr, Magdalena Eriksson
The study aimed at investigating the effects of adult uncomplicated malaria on insulin resistance. Fasting levels of blood glucose (FBG), glycosylated hemoglobin (HbA1c), and serum insulin were measured in 100 diabetics and 100 age-matched controls before and during Plasmodium falciparum malaria. Insulin resistance and beta cell function were computed by homeostatic models assessment of insulin resistance (HOMAIR) and beta cell function (HOMAB) formulae, respectively. Body mass index (BMI) was computed. At baseline, diabetics had significantly (P < 0...
2014: Malaria Research and Treatment
https://www.readbyqxmd.com/read/22973513/variation-in-apol1-contributes-to-ancestry-level-differences-in-hdlc-kidney-function-association
#7
Amy Rebecca Bentley, Ayo P Doumatey, Guanjie Chen, Hanxia Huang, Jie Zhou, Daniel Shriner, Congqing Jiang, Zhenjian Zhang, Guozheng Liu, Olufemi Fasanmade, Thomas Johnson, Johnnie Oli, Godfrey Okafor, Benjamin A Eghan, Kofi Agyenim-Boateng, Jokotade Adeleye, Williams Balogun, Clement Adebamowo, Albert Amoah, Joseph Acheampong, Adebowale Adeyemo, Charles N Rotimi
Low levels of high-density cholesterol (HDLc) accompany chronic kidney disease, but the association between HDLc and the estimated glomerular filtration rate (eGFR) in the general population is unclear. We investigated the HDLc-eGFR association in nondiabetic Han Chinese (HC, n = 1100), West Africans (WA, n = 1497), and African Americans (AA, n = 1539). There were significant differences by ancestry: HDLc was positively associated with eGFR in HC (β = 0.13, P < 0.0001), but negatively associated among African ancestry populations (WA: -0...
2012: International Journal of Nephrology
https://www.readbyqxmd.com/read/22519123/violet-diode-laser-induced-chlorophyll-fluorescence-a-tool-for-assessing-mosaic-disease-severity-in-cassava-manihot-esculenta-crantz-cultivars
#8
Benjamin Anderson, Moses J Eghan, Elvis Asare-Bediako, Paul K Buah-Bassuah
Violet diode laser-induced chlorophyll fluorescence was used in agronomical assessment (disease severity and average yield per plant). Because cassava (Manihot esculenta Crantz) is of economic importance, improved cultivars with various levels of affinity for cassava mosaic disease were investigated. Fluorescence data correlated with cassava mosaic disease severity levels and with the average yield per plant.
January 2012: Environmental Technology
https://www.readbyqxmd.com/read/22492993/c-reactive-protein-crp-promoter-polymorphisms-influence-circulating-crp-levels-in-a-genome-wide-association-study-of-african-americans
#9
Ayo P Doumatey, Guanjie Chen, Fasil Tekola Ayele, Jie Zhou, Michael Erdos, Daniel Shriner, Hanxia Huang, Jokotade Adeleye, Williams Balogun, Olufemi Fasanmade, Thomas Johnson, Johnnie Oli, Godfrey Okafor, Albert Amoah, Benjamin A Eghan, Kofi Agyenim-Boateng, Joseph Acheampong, Clement Adebamowo, Norman P Gerry, Michael F Christman, Adebowale Adeyemo, Charles N Rotimi
C-reactive protein (CRP) is an acute phase reactant protein produced primarily by the liver. Circulating CRP levels are influenced by genetic and non-genetic factors, including infection and obesity. Genome-wide association studies (GWAS) provide an unbiased approach towards identifying loci influencing CRP levels. None of the six GWAS for CRP levels has been conducted in an African ancestry population. The present study aims to: (i) identify genetic variants that influence serum CRP in African Americans (AA) using a genome-wide association approach and replicate these findings in West Africans (WA), (ii) assess transferability of major signals for CRP reported in European ancestry populations (EA) to AA and (iii) use the weak linkage disequilibrium (LD) structure characteristic of African ancestry populations to fine-map the previously reported CRP locus...
July 1, 2012: Human Molecular Genetics
https://www.readbyqxmd.com/read/22205395/genome-wide-associated-loci-influencing-interleukin-il-10-il-1ra-and-il-6-levels-in-african-americans
#10
Fasil Tekola Ayele, Ayo Doumatey, Hanxia Huang, Jie Zhou, Bashira Charles, Michael Erdos, Jokotade Adeleye, Williams Balogun, Olufemi Fasanmade, Thomas Johnson, Johnnie Oli, Godfrey Okafor, Albert Amoah, Benjamin A Eghan, Kofi Agyenim-Boateng, Joseph Acheampong, Clement A Adebamowo, Alan Herbert, Norman Gerry, Michael Christman, Guanjie Chen, Daniel Shriner, Adebowale Adeyemo, Charles N Rotimi
Interleukins (ILs) are key mediators of the immune response and inflammatory process. Plasma levels of IL-10, IL-1Ra, and IL-6 are associated with metabolic conditions, show large inter-individual variations, and are under strong genetic control. Therefore, elucidation of the genetic variants that influence levels of these ILs provides useful insights into mechanisms of immune response and pathogenesis of diseases. We conducted a genome-wide association study (GWAS) of IL-10, IL-1Ra, and IL-6 levels in 707 non-diabetic African Americans using 5,396,780 imputed and directly genotyped single nucleotide polymorphisms (SNPs) with adjustment for gender, age, and body mass index...
May 2012: Immunogenetics
https://www.readbyqxmd.com/read/20229387/use-of-isotopes-to-study-floodplain-wetland-and-river-flow-interaction-in-the-white-volta-river-basin-ghana
#11
Benjamin Kofi Nyarko, David Kofi Essumang, Moses J Eghan, Barbara Reichert, Nick van de Giesen, Paul Vlek
Floodplain wetlands influence the timing and magnitude of stream responses to rainfall. In managing and sustaining the level of water resource usage in any river catchment as well as when modelling hydrological processes, it is essential that the role of floodplain wetlands in stream flows is recognised and understood. Existing studies on hydrology within the Volta River basin have not adequately represented the variability of wetland hydrological processes and their contribution to the sustenance of river flow...
March 2010: Isotopes in Environmental and Health Studies
https://www.readbyqxmd.com/read/19469883/survival-pattern-of-hemodialysis-patients-in-kumasi-ghana-a-summary-of-forty-patients-initiated-on-hemodialysis-at-a-new-hemodialysis-unit
#12
Benjamin A Eghan, Kwabena Amoako-Atta, Charity Ama Kankam, Anthony Nsiah-Asare
To evaluate the survival pattern of hemodialysis patients at a dialysis unit in Kumasi, Ghana, through a retrospective (observational) study. Patients who were placed on hemodialysis at the dialysis unit at Komfo Anokye teaching hospital from October 25, 2006 to December 2007. The patients were followed from initiation of dialysis until December 31, 2007. The overall mortality was 14 (35.9%) on the incident population for the period and that for the first 90 days was 12 (32.4%) patients. Chronic glomerulonephritis was the underlying kidney disease in 35...
October 2009: Hemodialysis International
https://www.readbyqxmd.com/read/18079690/polymorphism-of-the-endothelial-nitric-oxide-synthase-gene-is-associated-with-diabetic-retinopathy-in-a-cohort-of-west-africans
#13
Yuanxiu Chen, Hanxia Huang, Jie Zhou, Ayo Doumatey, Kerrie Lashley, Guanjie Chen, Kofi Agyenim-Boateng, Benjamin A Eghan, Joseph Acheampong, Olufemi Fasanmade, Thomas Johnson, Folasade B Akinsola, Godfrey Okafor, Johnnie Oli, Felix Ezepue, Albert Amoah, Stephen Akafo, Adebowale Adeyemo, Charles N Rotimi
PURPOSE: In addition to chronic hyperglycemia, there is increasing evidence that genetic factors may be important in the development of diabetes retinopathy (DR). Specifically, polymorphisms of the endothelial nitric oxide synthase gene (eNOS) have been reported to be associated with multiple health conditions including DR, hypertension, nephropathy, and cardiovascular diseases in several ethnic groups. However, there is a paucity of similar data in African Americans and other African populations...
2007: Molecular Vision
https://www.readbyqxmd.com/read/18072386/prevalence-and-predictors-of-microalbuminuria-in-patients-with-diabetes-mellitus-a-cross-sectional-observational-study-in-kumasi-ghana
#14
Benjamin A Eghan, Magaret T Frempong, Micheal Adjei-Poku
OBJECTIVE: To evaluate the prevalence and predictors of microalbuminuria in diabetics in Kumasi, Ghana. DESIGN: Prospective, cross-sectional study of diabetic patients. SUBJECTS: Patients with diabetes, 20 to 78 years of age. MAIN OUTCOME MEASURES: Microalbuminuria METHODS: All patients (109) attending an outpatient diabetic clinic at the Komfo Anokye Teaching Hospital Diabetes Centre in Kumasi, Ghana from January to July 2005 were enrolled in the study...
2007: Ethnicity & Disease
https://www.readbyqxmd.com/read/17548123/genome-wide-search-for-susceptibility-genes-to-type-2-diabetes-in-west-africans-potential-role-of-c-peptide
#15
Guanjie Chen, Adebowale Adeyemo, Jie Zhou, Yuanxiu Chen, Hanxia Huang, Ayo Doumatey, Kerrie Lashley, Kofi Agyenim-Boateng, Benjamin A Eghan, Joseph Acheampong, Olufemi Fasanmade, Thomas Johnson, Godfrey Okafor, Johnnie Oli, Albert Amoah, Charles Rotimi
C-peptide is a substance that the pancreas releases into the circulation in equimolar amounts to insulin and has demonstrated important physiological effects which relate to the vascular field, in particular the microcirculation. For this analysis, we included 321 full and 36 half sibling pairs affected with type 2 diabetes (T2D) from West Africa. A genome-wide panel of 390 tri-nucleotide and tetra-nucleotide repeats with an average distance of 8.9 cM was performed on a total of 691 persons. Variance components based on multipoint linkage approach as implemented in SOLAR were performed for log C-peptide...
December 2007: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/17336700/a-genome-wide-search-for-linkage-to-renal-function-phenotypes-in-west-africans-with-type-2-diabetes
#16
Guanjie Chen, Adebowale A Adeyemo, Jie Zhou, Yuanxiu Chen, Ayo Doumatey, Kerrie Lashley, Hanxia Huang, Albert Amoah, Kofi Agyenim-Boateng, Benjamin A Eghan, Godfrey Okafor, Joseph Acheampong, Johnnie Oli, Olufemi Fasanmade, Thomas Johnson, Charles Rotimi
BACKGROUND: Reduced renal function often is a major consequence of diabetes and hypertension. Although several indices of renal function (eg, creatinine clearance) are clearly heritable and show linkage to several genomic regions, the specific underlying genetic determinants are still being sought. The purpose of this study is to conduct a genome-wide search for regions linked to 3 renal function phenotypes, serum creatinine, creatinine clearance, and glomerular filtration rate (GFR), in persons with type 2 diabetes...
March 2007: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/16877390/genomewide-scan-and-fine-mapping-of-quantitative-trait-loci-for-intraocular-pressure-on-5q-and-14q-in-west-africans
#17
Charles N Rotimi, Guanjie Chen, Adebowale A Adeyemo, Leslie S Jones, Kofi Agyenim-Boateng, Benjamin A Eghan, Jie Zhou, Ayo Doumatey, Karrie Lashley, Hanxia Huang, Olufemi Fasanmade, Folasade B Akinsola, Felix Ezepue, Albert Amoah, Stephen Akafo, Yuanxiu Chen, Johnnie Oli, Thomas Johnson
PURPOSE: High intraocular pressure (IOP) is a major risk factor for glaucoma, one of the leading causes of blindness worldwide. Because it has been demonstrated that African populations are at increased risk for glaucoma, the authors investigated the genetic basis of IOP in a sample of West Africans with type 2 diabetes (T2D) from Ghana and Nigeria. METHODS: Genomewide linkage analysis was conducted for loci linked to IOP (measured by applanation tonometry) in 244 affected sibling pairs with T2D using 372 autosomal short-tandem repeat markers at an average spacing of 9 cM...
August 2006: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/16039295/a-genome-wide-quantitative-trait-linkage-analysis-for-serum-lipids-in-type-2-diabetes-in-an-african-population
#18
Adebowale A Adeyemo, Thomas Johnson, Joseph Acheampong, Johnnie Oli, Godfrey Okafor, Albert Amoah, Samuel Owusu, Kofi Agyenim-Boateng, Benjamin A Eghan, Fayeofori Abbiyesuku, Olufemi Fasanmade, Theresa Rufus, Ayo Doumatey, Guanjie Chen, Jie Zhou, Yuanxiu Chen, Paulette Furbert-Harris, Georgia Dunston, Francis Collins, Charles Rotimi
Lipid abnormalities are strongly linked with coronary heart disease and are common in type 2 diabetes. However, little is known about the genetic determinants of serum lipids in African populations. An autosomal genome scan was performed for linkage to five plasma lipid phenotypes (total cholesterol, triglycerides (TG), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C) and VLDL-cholesterol (VLDL-C)) in the Africa-America Diabetes Mellitus (AADM) study. Two hundred and ninety-five affected sibling pairs with type 2 diabetes mellitus enrolled from Ghana and Nigeria were genotyped for 390 microsatellite markers with an average inter-marker distance of 9cM...
August 2005: Atherosclerosis
https://www.readbyqxmd.com/read/15652721/calpain-10-gene-polymorphisms-and-type-2-diabetes-in-west-africans-the-africa-america-diabetes-mellitus-aadm-study
#19
Yuanxiu Chen, Rick Kittles, Jie Zhou, Guanjie Chen, Adebowale Adeyemo, Ramesh K Panguluri, Weidong Chen, Albert Amoah, Victoria Opoku, Joseph Acheampong, Kofi Agyenim-Boateng, Benjamin Ackon Eghan, Awuah Nyantaki, Johnnie Oli, Godfrey Okafor, Esther Ofoegbu, Babatunde Osotimehin, Fayeofori Abbiyesuku, Thomas Johnson, Olufemi Fasanmade, Theresa Rufus, Paulette Furbert-Harris, Harold I Daniel, Kate A Berg, Francis S Collins, Georgia M Dunston, Charles N Rotimi
PURPOSE: To investigate whether the three single nucleotide polymorphisms (SNPs), SNP-43, -56, and -63 of CAPN10 were associated with type 2 diabetes in a West African cohort. METHODS: A total of 347 diabetic subjects and 148 unaffected controls from four ethnic groups in two West African countries were enrolled in this study. After genotyping three SNPs of CAPN10 and one SNP from CYP19, the allele, genotype, and haplotype frequencies as well as the odds ratios were calculated to test their association with type 2 diabetes...
February 2005: Annals of Epidemiology
https://www.readbyqxmd.com/read/14988271/a-genome-wide-search-for-type-2-diabetes-susceptibility-genes-in-west-africans-the-africa-america-diabetes-mellitus-aadm-study
#20
MULTICENTER STUDY
Charles N Rotimi, Guanjie Chen, Adebowale A Adeyemo, Paulette Furbert-Harris, Debra Parish-Gause, Jie Zhou, Kate Berg, Olufemi Adegoke, Albert Amoah, Samuel Owusu, Joseph Acheampong, Kofi Agyenim-Boateng, Benjamin A Eghan, Johnnie Oli, Godfrey Okafor, Ester Ofoegbu, Babatunde Osotimehin, Fayeofori Abbiyesuku, Thomas Johnson, Theresa Rufus, Olufemi Fasanmade, Rick Kittles, Harold Daniel, Yuanxiu Chen, Georgia Dunston, Francis S Collins, Debra Guass et al.
The incidence of type 2 diabetes is growing rapidly, not only in developed countries but also worldwide. We chose to study type 2 diabetes in West Africa, where diabetes is less common than in the U.S., reasoning that in an environment where calories are less abundant, incident cases of type 2 diabetes might carry a proportionately greater genetic component. Through the Africa America Diabetes Mellitus (AADM) study, we carried out a genome-wide linkage analysis of type 2 diabetes in a cohort of 343 affected sibling pairs (691 individuals) enrolled from five West African centers in two countries (Ghana: Accra and Kumasi; Nigeria: Enugu, Ibadan, and Lagos)...
March 2004: Diabetes
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