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https://www.readbyqxmd.com/read/29245132/transcriptome-analysis-reveals-novel-insights-into-the-response-to-pb-exposure-in-phanerochaete-chrysosporium
#1
Chao Huang, Rongzhong Wang, Guangming Zeng, Danlian Huang, Cui Lai, Jiachao Zhang, Zhihua Xiao, Jia Wan, Piao Xu, Xiaomin Gong, Wenjing Xue, Xiaoya Ren
Metals released into the environment continue to be of concern for human health. Using white-rot fungi as biosorbents for heavy metals removal is an attractive alternative owing to its good performance and low cost. However, the molecular mechanism underlying heavy metal tolerance in white-rot fungi has not yet been fully elucidated. This study identified and analyzed the lead (Pb)-induced transcriptional changes in Phanerochaete chrysosporium, a well-known heavy metal hyperaccumulating white-rot fungus. The results confirmed its outstanding ability in Pb tolerance and effective defense system...
December 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/29245127/exogenous-allantoin-increases-arabidopsis-seedlings-tolerance-to-nacl-stress-and-regulates-expression-of-oxidative-stress-response-genes
#2
Solmaz Irani, Christopher D Todd
Allantoin is a nitrogenous compound derived from purine catabolism that contributes to nitrogen recycling in plants. Accumulation of allantoin in plant tissues and a potential role in protection of plants from abiotic stress conditions has been identified. The present work shows that application of exogenous allantoin increased stress tolerance of Arabidopsis seedlings when germinated on, or subjected to the media containing NaCl. Allantoin-induced tolerance to NaCl stress was associated with decreased production of superoxide and hydrogen peroxide in seedlings...
December 7, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29245084/application-of-analytical-quality-by-design-principles-for-the-determination-of-alkyl-p-toluenesulfonates-impurities-in-aprepitant-by-hplc-validation-using-total-error-concept
#3
Constantinos K Zacharis, Elli Vastardi
In the research presented we report the development of a simple and robust liquid chromatographic method for the quantification of two genotoxic alkyl sulphonate impurities (namely methyl p-toluenesulfonate and isopropyl p-toluenesulfonate) in Aprepitant API substances using the Analytical Quality by Design (AQbD) approach. Following the steps of AQbD protocol, the selected critical method attributes (CMAs) were the separation criterions between the critical peak pairs, the analysis time and the peak efficiencies of the analytes...
December 7, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29244870/human-hepatic-lipase-overexpression-in-mice-induces-hepatic-steatosis-and-obesity-through-promoting-hepatic-lipogenesis-and-white-adipose-tissue-lipolysis-and-fatty-acid-uptake
#4
Lídia Cedó, David Santos, Núria Roglans, Josep Julve, Victor Pallarès, Andrea Rivas-Urbina, Vicenta Llorente-Cortes, Joan Carles Laguna, Francisco Blanco-Vaca, Joan Carles Escolà-Gil
Human hepatic lipase (hHL) is mainly localized on the hepatocyte cell surface where it hydrolyzes lipids from remnant lipoproteins and high density lipoproteins and promotes their hepatic selective uptake. Furthermore, hepatic lipase (HL) is closely associated with obesity in multiple studies. Therefore, HL may play a key role on lipid homeostasis in liver and white adipose tissue (WAT). In the present study, we aimed to evaluate the effects of hHL expression on hepatic and white adipose triglyceride metabolism in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/29244851/inhibition-of-merozoite-invasion-and-transient-de-sequestration-by-sevuparin-in-humans-with-plasmodium-falciparum-malaria
#5
Anna M Leitgeb, Prakaykaew Charunwatthana, Ronnatrai Rueangveerayut, Chirapong Uthaisin, Kamolrat Silamut, Kesinee Chotivanich, Patima Sila, Kirsten Moll, Sue J Lee, Maria Lindgren, Erik Holmer, Anna Färnert, Mpungu S Kiwuwa, Jens Kristensen, Christina Herder, Joel Tarning, Mats Wahlgren, Arjen M Dondorp
SEVERE MALARIA: Even with the best available treatment, the mortality from severe Plasmodium falciparum malaria remains high. Typical features at death are high parasite loads and obstructed micro- vasculature. Infected erythrocytes (IE) containing mature parasites bind to the host receptor heparan sulfate, which is also an important receptor for merozoite invasion. To block merozoite invasion has not previously been proposed as an adjunctive therapeutic approach but it may preclude the early expansion of an infection that else leads to exacerbated sequestration and death...
2017: PloS One
https://www.readbyqxmd.com/read/29244745/immunotherapeutic-potential-of-oncolytic-h-1-parvovirus-hints-of-glioblastoma-microenvironment-conversion-towards-immunogenicity
#6
Assia L Angelova, Milena Barf, Karsten Geletneky, Andreas Unterberg, Jean Rommelaere
Glioblastoma, one of the most aggressive primary brain tumors, is characterized by highly immunosuppressive microenvironment. This contributes to glioblastoma resistance to standard treatment modalities and allows tumor growth and recurrence. Several immune-targeted approaches have been recently developed and are currently under preclinical and clinical investigation. Oncolytic viruses, including the autonomous protoparvovirus H-1 (H-1PV), show great promise as novel immunotherapeutic tools. In a first phase I/IIa clinical trial (ParvOryx01), H-1PV was safe and well tolerated when locally or systemically administered to recurrent glioblastoma patients...
December 15, 2017: Viruses
https://www.readbyqxmd.com/read/29244608/safety-and-efficacy-of-intralesional-triamcinolone-administration-for-treatment-of-mast-cell-tumors-in-dogs-23-cases-2005-2011
#7
Ashley Case, Kristine Burgess
OBJECTIVE To evaluate the safety and efficacy of intralesional triamcinolone administration, as a sole or adjuvant treatment, in dogs with mast cell tumors. DESIGN Retrospective case series ANIMALS 23 dogs with mast cell tumors. PROCEDURES Medical records of dogs treated for a confirmed diagnosis of a mast cell tumor between 2005 and 2011 were reviewed. Patients with a confirmed diagnosis and measurable disease (tumor longest dimension ≥ 0.5 cm) that had received ≥ 1 intralesional treatment with triamcinolone, regardless of prior, concurrent, or adjuvant treatments, were eligible for inclusion...
January 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29244512/cuh-catalyzed-asymmetric-intramolecular-reductive-coupling-of-allenes-to-enones
#8
Yun-Xuan Tan, Xiao-Qi Tang, Ping Liu, De-Shen Kong, Ya-Li Chen, Ping Tian, Guo-Qiang Lin
The CuH-catalyzed asymmetric intramolecular reductive coupling of allenes to enones is successfully realized, providing cis-hydrobenzofurans with promising yields and excellent enantioselectivities. Such brilliant enantioselectivities are partially contributed by CuH-catalyzed favorable kinetic resolution of the cyclization products. This protocol tolerates a broad range of functional groups, allowing for further construction of tricyclic and bridged-ring structures. Moreover, the meta-chiral functionalization of 4-substituted phenol and asymmetric dearomatization modification of phenol-contained bioactive molecules are also described...
December 15, 2017: Organic Letters
https://www.readbyqxmd.com/read/29244162/efficacy-and-safety-of-biologics-targeting-interleukin-6-12-23-and-17-pathways-for-peripheral-psoriatic-arthritis-a-network-meta-analysis
#9
Dongze Wu, Jiang Yue, Lai-Shan Tam
Objective: To investigate the comparative efficacy, safety and tolerability of IL-6, IL-12/23 and IL-17 inhibitors for patients with active PsA. Methods: Randomized controlled trials evaluating the efficacy, safety and tolerability of IL-6, IL-12/23 and IL-17 inhibitors were identified by a comprehensive systematic literature review. Pairwise meta-analyses and Bayesian network meta-analyses using the random effects model were performed to estimate pooled odds ratios (ORs) and 95% credible intervals of attaining a 20% or 50% improvement in ACR criteria (ACR20 and ACR50, respectively) across trials...
December 13, 2017: Rheumatology
https://www.readbyqxmd.com/read/29244141/telavancin-for-refractory-mrsa-bacteraemia-in-intermittent-haemodialysis-recipients
#10
Nicholas S Britt, Samad Tirmizi, David J Ritchie, Jeffrey E Topal, Dayna McManus, Victor Nizet, Ed Casabar, George Sakoulas
Background: Patients with end-stage renal disease (ESRD) requiring intermittent haemodialysis (IHD) are at high risk of MRSA bacteraemia (MRSA-B) and often fail first-line therapy. The safety, effectiveness and optimal dosing of telavancin for MRSA-B in this patient population are unclear. Objectives: We aimed to describe clinical outcomes of telavancin in the treatment of refractory MRSA-B in patients with ESRD requiring IHD. Patients and methods: This was a retrospective study of hospitalized patients at two tertiary care academic medical centres with recurrent or persistent (≥3 days) MRSA-B treated with telavancin monotherapy...
December 13, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29244078/patterns-of-plasma-glucagon-dynamics-do-not-match-metabolic-phenotypes-in-young-women
#11
Christina Gar, Marietta Rottenkolber, Vanessa Sacco, Sarah Moschko, Friederike Banning, Nina Hesse, Daniel Popp, Christoph Hübener, Jochen Seissler, Andreas Lechner
Context: The role of hyperglucagonemia in type 2 diabetes is still debated. Objective: We analyzed glucagon dynamics during oral glucose tolerance testing (oGTT) in young women with 1 out of 3 metabolic phenotypes: healthy control (normoglycemic after a normoglycemic pregnancy); normoglycemic high-risk (normoglycemic after a pregnancy complicated by gestational diabetes); and prediabetes/screening-diagnosed T2D. We asked if glucagon patterns were homogeneous within the metabolic phenotypes...
December 13, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29244064/%C3%AE-cell-control-of-insulin-production-during-starvation-refeeding-in-male-rats
#12
Brandon B Boland, Charles Brown, Cristina Alarcon, Damien Demozay, Joseph S Grimsby, Christopher J Rhodes
Mammalian metabolism has evolved to adapt relative to changes in nutrient status. Insulin, the key anabolic hormone, facilitates intracellular storage of nutrient fuels and plays a pivotal role in the transition away from catabolism upon refeeding. While circulating insulin relative to nutrient levels has been well-characterized during both fasting and refeeding, how pancreatic β-cell biology caters to acute changes in insulin demand has not been sufficiently addressed. Here, we examined the dynamics of (pro)insulin production and associated changes in β-cell ultrastructure during refeeding after a prolonged 72 hour fast in male rats...
December 13, 2017: Endocrinology
https://www.readbyqxmd.com/read/29244026/jnj-63623872-treatment-in-adult-volunteers-experimentally-inoculated-with-live-influenza-virus-a-phase-iia-randomized-double-blind-placebo-controlled-study
#13
Jose M Trevejo, Mohammed Asmal, Johan Vingerhoets, Ramon Polo, Sarah Robertson, Ying Jiang, Tara L Kieffer, Lorant Leopold
BACKGROUND: JNJ-63623872 is a novel, non-nucleoside polymerase complex inhibitor with in vitro activity against influenza A virus, including pandemic 2009 H1N1, H7N9, H5N1 strains as well as neuraminidase-and amantadine-resistant strains. METHODS: Randomized, double-blind, placebo-controlled, Phase 2a study. Healthy volunteers (N = 104) were inoculated with an influenza A/Wisconsin/67/2005 (H3N2) challenge virus. 72 received JNJ-63623872 and 32 placebo. JNJ-63623872 was dosed for 5 days once daily from 24 hours after viral inoculation at four dose levels: 100 mg, 400 mg, loading dose 900/600 mg and loading dose 1200/600 mg...
December 15, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/29243965/enasidenib-a-targeted-inhibitor-of-mutant-idh2-proteins-for-treatment-of-relapsed-or-refractory-acute-myeloid-leukemia
#14
Eytan M Stein
Mutations in IDH2 genes (mIDH2) occur in approximately 12% of patients with acute myeloid leukemia. Enasidenib is an oral, small-molecule inhibitor of mIDH2 proteins. Enasidenib is shown to suppress the oncometabolite, 2-hydroxyglutarate, and promote differentiation of leukemic bone marrow blasts. In a Phase I dose-escalation and expansion study, 40.3% of patients with relapsed/refractory acute myeloid leukemia responded to enasidenib monotherapy, including 19.3% who achieved complete remission and 11% who proceeded to transplant...
January 2018: Future Oncology
https://www.readbyqxmd.com/read/29243905/silver-niobate-lead-free-antiferroelectric-ceramics-enhancing-energy-storage-density-by-b-site-doping
#15
Lei Zhao, Jing Gao, Qing Liu, Shujun Zhang, Jing-Feng Li
Lead-free dielectric ceramics with high recoverable energy density are highly desired to sustainably meet the future energy demand. AgNbO3-based lead-free antiferroelectric ceramics with double ferroelectric hysteresis loops have been proved to be a potential candidate for energy storage applications. Enhanced energy storage performance with recoverable energy density of 3.3J/cm3, and high thermal stability with minimal energy density variation (<10%) over temperature range of 20-120oC, have been achieved in W-modified AgNbO3 ceramics...
December 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29243883/aspects-of-silver-tolerance-in-bacteria-ir-spectral-changes-and-epigenetic-clues
#16
Rafig Gurbanov, Nihal Simsek Ozek, Sinem Tunçer, Feride Severcan, Ayse Gul Gozen
In this study, the molecular profile changes leading to the adaptation of bacteria to survive and grow at inhibitory silver concentration were explored. The profile obtained through infrared (IR)-based measurements indicated extensive changes in all biomolecular components, which were supported by chemometric techniques. The changes in biomolecular profile were prominent including nucleic acids. The changes in nucleic acid region (1350-950 cm-1 ) were encountered as a clue for conformational change in DNA. Further analysis of DNA by IR spectroscopy revealed changes in the backbone and sugar conformations...
December 15, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29243826/gsslah3-a-glycine-soja-slow-type-anion-channel-homologue-positively-modulates-plant-bicarbonate-stress-tolerance
#17
Xiangbo Duan, Yang Yu, Huizi Duanmu, Chao Chen, Xiaoli Sun, Lei Cao, Qiang Li, Xiaodong Ding, Beidong Liu, Yanming Zhu
Alkaline stress is a major form of abiotic stress that severely inhibits plant growth and development, thus restricting crop productivity. However, little is known about how plants respond to alkali. In this study, a slow-type anion channel homologue 3 gene GsSLAH3 was isolated and functionally characterized. Bioinformatics analysis showed that GsSLAH3 protein contains ten transmembrane helices. Consistently, GsSLAH3 was found to locate on plasma membrane by transient expression in onion epidermal cells. In wild soybeans, GsSLAH3 expression was induced by NaHCO3 treatment, suggesting its involvement in plant response to alkaline stress...
December 15, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/29243589/defective-stim-mediated-store-operated-ca2-entry-in-hepatocytes-leads-to-metabolic-dysfunction-in-obesity
#18
Ana Paula Arruda, Benedicte Mengel Pers, Günes Parlakgul, Ekin Güney, Ted Goh, Erika Cagampan, Grace Yankun Lee, Renata L Goncalves, Gökhan S Hotamisligil
Defective Ca2+ handling is a key mechanism underlying hepatic endoplasmic reticulum (ER) dysfunction in obesity. ER Ca2+ level is in part monitored by the store-operated Ca2+ entry (SOCE) system, an adaptive mechanism that senses ER luminal Ca2+ concentrations through the STIM proteins and facilitates import of the ion from the extracellular space. Here, we show that hepatocytes from obese mice displayed significantly diminished SOCE as a result of impaired STIM1 translocation, which was associated with aberrant STIM1 O-GlycNAcylation...
December 15, 2017: ELife
https://www.readbyqxmd.com/read/29243490/percutaneous-cryoablation-of-breast-tumors-in-patients-with-stable-metastatic-breast-cancer-safety-feasibility-and-efficacy
#19
Beji H, Pilleul F, Picard R, Tredan O, Bouhamama A, Peix M, Mavrovi E, Mastier C
PURPOSE: To evaluate safety, feasibility, and efficacy of percutaneous cryoablation of breast tumors in patients with clinically stable metastatic breast cancer, and to compare the findings with reports on alternative procedures, namely surgery and local radiotherapy. METHODS: Seventeen female patients (average age of 54.8 years +/- 10.8 ; range 37-72) with primary breast tumor not surgically treated because of metastatic disease were included. Patients were treated for their primary lesion by percutaneous cryotherapy in period of stable disease...
December 15, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29243413/clinical-response-to-apatinib-monotherapy-in-advanced-non-small-cell-lung-cancer
#20
Jianping Xu, Xiaoyan Liu, Sheng Yang, Xiangru Zhang, Yuankai Shi
AIM: Apatinib, an oral tyrosine kinase inhibitor mainly targeting VEGFR-2, exerts both antiangiogenesis and antiproliferation effects. Apatinib shows clinical benefit in advanced non-small cell lung cancer (NSCLC) at an initial dose of 750 mg qd. We further assessed the efficacy and safety of apatinib at a more frequently used dose of 500 mg qd. The preliminary clinical outcome of apatinib in patients with brain metastases was also reported. METHODS: We retrospectively reviewed the clinical data of 25 patients who received apatinib between August 2015 and May 2016...
December 15, 2017: Asia-Pacific Journal of Clinical Oncology
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