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https://www.readbyqxmd.com/read/29031181/mdhy5-positively-regulates-cold-tolerance-via-cbf-dependent-and-cbf-independent-pathways-in-apple
#1
Jian-Ping An, Ji-Fang Yao, Xiao-Na Wang, Chun-Xiang You, Xiao-Fei Wang, Yu-Jin Hao
Cold stress is a major external stimulator that affects crop quality and productivity. The CBF cold regulatory pathway has been regarded as a master regulator in the response to cold stress. In this study, we found that the apple bZIP transcription factor, MdHY5, was responsive to cold treatment both at the transcriptional and at the post-translational levels. Moreover, overexpression of MdHY5 enhanced cold tolerance in apple calli and Arabidopsis. Subsequently, EMSA assay and transient expression assay demonstrated that MdHY5 positively regulated the transcript of MdCBF1 by binding to G-Box motif of its promoter...
September 7, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29031170/a-dose-escalation-study-of-bi-daily-once-weekly-oral-docetaxel-either-as-modradoc001-or-modradoc006-combined-with-ritonavir
#2
Vincent A de Weger, Frederik E Stuurman, Jeroen J M A Hendrikx, Johannes J Moes, Emilia Sawicki, Alwin D R Huitema, Bastiaan Nuijen, Bas Thijssen, Hilde Rosing, Marianne Keessen, Marja Mergui-Roelvink, Jos H Beijnen, Jan H M Schellens, Serena Marchetti
INTRODUCTION: Two solid dispersions of docetaxel (denoted ModraDoc001 capsule and ModraDoc006 tablet (both 10 mg)) were co-administered with 100 mg ritonavir (/r) and investigated in a bi-daily once weekly (BIDW) schedule. Safety, maximum tolerated dose (MTD), pharmacokinetics (PK) and preliminary activity were explored. METHODS: Adult patients with metastatic solid tumours were included in two dose-escalation arms. PK sampling was performed during the first week and the second or third week...
October 11, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29031161/understanding-the-role-of-dna-polymerase-%C3%AE-gene-in-different-growth-and-developmental-stages-of-oryza-sativa-l-indica-rice-cultivars
#3
Sayantani Sihi, Soumitra Maiti, Sankar Bakshi, Arup Nayak, Shubho Chaudhuri, Dibyendu Narayan Sengupta
DNA polymerase λ (Pol λ) is the only member of DNA polymerase family X present in plants. The enzyme is ddNTP sensitive as it contains the conserved C-terminal Pol β domain. The 1.1 kb partial coding sequence isolated spanned the whole 3' regions of the gene containing functionally important domains of the Pol λ gene. Comparative in silico studies from both indica and japonica cultivars involving homology modelling showed that the model for the partial Pol λ gene was stable and acceptable. The alignment of both the protein models showed a RMS value of 0...
October 4, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29031118/chemical-elements-in-mediterranean-macroalgae-a-review
#4
REVIEW
Giuseppe Bonanno, Martina Orlando-Bonaca
This review analyzes the state of knowledge on the capacity of Mediterranean macroalgae to accumulate, tolerate and biomonitor macro- and micro-elements present in seawater and sediments. The results show that the investigated macroalgal species amount to c. 5.0% of all Mediterranean native Rhodophyta, Chlorophyta and Ochrophyta. The most commonly analyzed elements in algae were Pb, Cd, Zn and Cu, whereas very few studies were available for macroelements such as Ca and K. Uptake mechanisms and the factors influencing accumulation are overall well known, but the available studies are restricted to a limited number of chemical elements and algal species...
October 11, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29031115/decolorization-and-detoxification-of-dye-mixture-and-textile-effluent-by-lichen-dermatocarpon-vellereceum-in-fixed-bed-upflow-bioreactor-with-subsequent-oxidative-stress-study
#5
Ashwini N Kulkarni, Anuprita D Watharkar, Niraj R Rane, Byong-Hun Jeon, Sanjay P Govindwar
Navy Blue HE22 (NBHE22), dye mixture and real textile effluent were decolorized and degraded by lichen Dermatocarpon vellereceum. Up-flow bioreactor showed about 80%, 70%, 80% and 65% removal of American dye manufacturer index (ADMI), biological oxygen demand (BOD), total suspended solids (TSS) and total dissolved solids (TDS), respectively of dye mixture at flow rate of 25mlh(-1). The removal of ADMI, BOD, TSS and TDS of real textile effluent were 75%, 65%, 82% and 70%, respectively at flow rate of 30mlh(-1)...
October 10, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29031018/strategies-to-define-performance-specifications-in-laboratory-medicine-3-years-on-from-the-milan-strategic-conference
#6
Mauro Panteghini, Ferruccio Ceriotti, Graham Jones, Wytze Oosterhuis, Mario Plebani, Sverre Sandberg
Measurements in clinical laboratories produce results needed in the diagnosis and monitoring of patients. These results are always characterized by some uncertainty. What quality is needed and what measurement errors can be tolerated without jeopardizing patient safety should therefore be defined and specified for each analyte having clinical use. When these specifications are defined, the total examination process will be "fit for purpose" and the laboratory professionals should then set up rules to control the measuring systems to ensure they perform within specifications...
October 14, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29029371/structures-of-a-complex-hydrazinium-lead-iodide-n2h5-15pb3i21-possessing-pb2i9-5-pbi6-4-and-i-ions-and-%C3%AE-and-%C3%AE-n2h5-pbi3
#7
Joel S Miller, Eric Campbell, Brandon Dick, Arnold Rheingold, Chuang Zhang, Xiaojie Liu, Zeev Vardeny
Photovoltaic Perovskites, most notably methylammonium lead triiodide, (NH3Me)PbI3, have recently attracted considerable attention, and based upon the 'Goldschmidt Tolerance Factor' hydrazinium should be able to occupy the same cation site as methylammonium. The reaction of N2H5+I- with PbI2 in DMF results in three types of yellow crystals; hexagonal, needle-like, and rod-like, whose structures were determined at 100 K. The hexagonal [P63/m: a = 10.8906(10) Å; b = 37.845(5) Å] crystals possess isolated face sharing octahedral [Pb2I9]5-, [PbI6]4-, and I- ions...
October 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29029278/efficacy-and-safety-of-delafloxacin-compared-with-vancomycin-plus-aztreonam-for-acute-bacterial-skin-and-skin-structure-infections-a-phase-3-double-blind-randomized-study
#8
J Pullman, J Gardovskis, B Farley, E Sun, M Quintas, L Lawrence, R Ling, S Cammarata
Background: Delafloxacin is an investigational anionic fluoroquinolone in development for oral or intravenous administration for the treatment of infections caused by Gram-positive (including MRSA), Gram-negative, atypical and anaerobic organisms. Objectives: To establish the non-inferiority of delafloxacin compared with vancomycin plus aztreonam for the treatment of acute bacterial skin and skin structure infections and to compare the safety of the two antimicrobials...
October 5, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29029265/preclinical-testing-of-a-broad-spectrum-antimicrobial-endotracheal-tube-coated-with-an-innate-immune-synthetic-mimic
#9
Marjan M Hashemi, John Rovig, Jordan Bateman, Brett S Holden, Tomasz Modelzelewski, Iliana Gueorguieva, Martin von Dyck, Ronald Bracken, Carl Genberg, Shenglou Deng, Paul B Savage
Background: Endotracheal tubes provide an abiotic surface on which bacteria and fungi form biofilms, and the release of endotoxins and planktonic organisms can cause damaging inflammation and infections. Objectives: Ceragenins are small molecule mimics of antimicrobial peptides with broad-spectrum antibacterial and antifungal activity, and a ceragenin may be used to provide antimicrobial protection to the abiotic surface of an endotracheal tube. Methods: A hydrogel film, containing CSA-131, was generated on endotracheal tubes...
October 4, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29029226/new-insights-into-the-genetic-basis-of-monge-s-disease-and-adaptation-to-high-altitude
#10
Tsering Stobdan, Ali Akbari, Priti Azad, Dan Zhou, Orit Poulsen, Otto Appenzeller, Gustavo F Gonzales, Amalio Telenti, Emily H M Wong, Shubham Saini, Ewen F Kirkness, J Craig Venter, Vineet Bafna, Gabriel G Haddad
Human high-altitude (HA) adaptation or mal-adaptation is explored to understand the physiology, pathophysiology and molecular mechanisms that underlie long-term exposure to hypoxia. Here we report the results of an analysis of the largest whole-genome-sequencing of Chronic Mountain Sickness (CMS) and non-CMS individuals, identified candidate genes and functionally validated these candidates in a genetic model system (Drosophila). We used PreCIOSS algorithm that uses Haplotype Allele Frequency score to separate haplotypes carrying the favored allele from the non-carriers and accordingly prioritize genes associated with the CMS or non-CMS phenotype...
September 19, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29029190/pharmacokinetics-of-igf-i-in-papp-a2-deficient-patients-growth-response-and-effects-on-glucose-and-bone-density
#11
Catalina Cabrera-Salcedo, Tomoyuki Mizuno, Leah Tyzinski, Melissa Andrew, Alexander A Vinks, Jan Frystyk, Halley Wasserman, Catherine M Gordon, Vivian Hwa, Philippe Backeljauw, Andrew Dauber
Context: PAPP-A2 cleaves IGFBP-3 and -5 releasing free IGF-I. Homozygous mutations in PAPP-A2 result in growth failure with elevated total but low free IGF-I. Objective: To determine the 24-hour pharmacokinetic profile of free and total IGF-I after a dose of rhIGF-I. We describe the growth response and effects on glucose metabolism and bone mineral density (BMD) after one year of rhIGF-I therapy. Design and patients: Three affected siblings, their heterozygous parents, and two healthy controls participated...
September 28, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29029122/immunogenicity-and-safety-of-the-hz-su-adjuvanted-herpes-zoster-subunit-vaccine-in-adults-previously-vaccinated-with-a-live-attenuated-herpes-zoster-vaccine
#12
Katrijn Grupping, Laura Campora, Martine Douha, Thomas C Heineman, Nicola P Klein, Himal Lal, James Peterson, Ilse Vastiau, Lidia Oostvogels
Background: Protection against herpes zoster (HZ) induced by the live-attenuated zoster vaccine Zostavax (ZVL) wanes within 3-7 years. Re-vaccination may renew protection. We assessed whether (re)-vaccination with the adjuvanted HZ subunit vaccine candidate (HZ/su) induced comparable immune responses in previous ZVL-recipients and ZVL-naïve individuals (HZ-NonVac). Methods: In an open-label, multicenter study (NCT02581410), adults ≥65 years of age, vaccinated with ZVL ≥5 years previously (HZ-PreVac), were matched to HZ-NonVac adults...
September 26, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29029084/penicillin-binding-protein-encoded-by-pbp4-is-involved-in-mediating-copper-stress-in-listeria-monocytogenes
#13
Cameron Parsons, Ben Costolo, Phillip Brown, Sophia Kathariou
Listeria monocytogenes raises major food safety and public health concerns due its potential for severe foodborne disease and persistent colonization of food processing facilities. Copper is often employed to control pathogens in agriculture and is increasingly used in healthcare facilities, but mechanisms mediating tolerance of L. monocytogenes to copper remain poorly understood. A mariner-based mutant library of L. monocytogenes 2011L-2858, implicated in the 2011 listeriosis outbreak via whole cantaloupe, was screened for growth at sublethal levels of copper yielding mutant G2B4 with decreased copper tolerance...
October 4, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29029081/rapid-cold-hardening-of-a-subtropical-species-maruca-vitrata-lepidoptera-crambidae-accompanies-hypertrehalosemia-by-upregulating-trehalose-6-phosphate-synthase
#14
Yonggyun Kim, Dae-Weon Lee, Jin Kyo Jung
A subtropical insect, Maruca vitrata (F.) (Lepidoptera: Crambidae), is invasive to temperate zones, in which low temperatures during winter would be a serious challenge for colonization. This study assessed cold tolerance and cold-hardening of M. vitrata to understand its overwintering mechanism. Supercooling capacity was confirmed in all developmental stages exhibiting body freezing points at lower than -10°C, in which supercooling points (SCPs) were significantly different among developmental stages, with eggs having the lowest SCP (at -22...
September 23, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/29028997/serum-quantitative-proteomic-analysis-reveals-soluble-egfr-to-be-a-marker-of-insulin-resistance-in-male-mice-and-humans
#15
Mayu Kyohara, Jun Shirakawa, Tomoko Okuyama, Ayuko Kimura, Yu Togashi, Kazuki Tajima, Hisashi Hirano, Yasuo Terauchi
To identify circulating factors as candidates involved in type 2 diabetes (T2DM), we conducted two different quantitative proteomic analyses: 1) db/db mouse sera were compared with db/+ mouse sera obtained at 4, 8, 12, and 24 weeks of age, and 2) db/db mouse sera from animals treated with liraglutide were compared with sera from animals without liraglutide treatment. 20 and eight proteins were differentially expressed in db/db mouse sera in the first experiment and in db/db mouse sera after liraglutide treatment in the second experiment, respectively...
October 5, 2017: Endocrinology
https://www.readbyqxmd.com/read/29028996/cold-tolerance-of-megacopta-cribraria-hemiptera-plataspidae-an-invasive-pest-of-soybeans
#16
Jessica I Grant, William O Lamp
Kudzu bug, Megacopta cribraria Fabricius (Hemiptera: Plataspidae), first discovered in the United States in 2009, is an invasive pest of soybeans. From 2013 to 2016, Maryland has been the northern limit of its distribution in the United States. We sought to determine the physiological cold temperature limits, timing of movement to overwintering locations, and to characterize overwintering microhabitat temperature. We measured supercooling point (SCP) on three populations from distinct USDA plant hardiness zones in Maryland and Virginia between October and December of 2015...
September 23, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/29028900/unravelling-the-biological-secrets-of-microchimerism-by-single-cell-analysis
#17
Anders Ståhlberg, Amin El-Heliebi, Peter Sedlmayr, Thomas Kroneis
The presence of microchimeric cells is known for >100 years and well documented since decades. Earlier, microchimeric cells were mainly used for cell-based non-invasive prenatal diagnostics during early pregnancy. Microchimeric cells are also present beyond delivery and are associated to various autoimmune diseases, tissue repair, cancer and immune tolerance. All these findings were based on low complexity studies and occasionally accompanied by artefacts not allowing the biological functions of microchimerism to be determined...
September 28, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/29028871/high-light-aggravates-functional-limitations-of-cucumber-canopy-photosynthesis-under-salinity
#18
Tsu-Wei Chen, Hartmut Stützel, Katrin Kahlen
Background and Aims: Most crop species are glycophytes, and salinity stress is one of the most severe abiotic stresses reducing crop yields worldwide. Salinity affects plant architecture and physiological functions by different mechanisms, which vary largely between crop species and determine the susceptibility or tolerance of a crop species to salinity. Methods: Experimental data from greenhouse cucumber (Cucumis sativus), a salt-sensitive species, grown under three salinity levels were interpreted by combining a functional-structural plant model and quantitative limitation analysis of photosynthesis...
September 19, 2017: Annals of Botany
https://www.readbyqxmd.com/read/29028868/symplasmic-and-apoplasmic-transport-inside-feather-moss-stems-of-pleurozium-schreberi-and-hylocomium-splendens
#19
K Sokolowska, M Turzanska, M-C Nilsson
Background and Aims: The ubiquitous feather mosses Pleurozium schreberi and Hylocomium splendens form a thick, continuous boundary layer between the soil and the atmosphere, and play important roles in hydrology and nutrient cycling in tundra and boreal ecosystems. The water fluxes among these mosses and environmental factors controlling them are poorly understood. The aim of this study was to investigate whether feather mosses are capable of internal transport and to provide a better understanding of species-specific morphological traits underlying this function...
September 28, 2017: Annals of Botany
https://www.readbyqxmd.com/read/29028804/a-recombinase-polymerase-amplification-assay-for-rapid-detection-of-crimean-congo-haemorrhagic-fever-virus-infection
#20
Laura C Bonney, Robert J Watson, Babak Afrough, Manija Mullojonova, Viktoriya Dzhuraeva, Farida Tishkova, Roger Hewson
BACKGROUND: Crimean-Congo Haemorrhagic fever Virus (CCHFV) is a rapidly emerging vector-borne pathogen and the cause of a virulent haemorrhagic fever affecting large parts of Europe, Africa, the Middle East and Asia. METHODOLOGY/PRINCIPLE FINDINGS: An isothermal recombinase polymerase amplification (RPA) assay was successfully developed for molecular detection of CCHFV. The assay showed rapid (under 10 minutes) detection of viral extracts/synthetic virus RNA of all 7 S-segment clades of CCHFV, with high target specificity...
October 13, 2017: PLoS Neglected Tropical Diseases
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