D Nicholas Bateman, James W Dear, H K Ruben Thanacoody, Simon H L Thomas, Michael Eddleston, Euan A Sandilands, Judy Coyle, Jamie G Cooper, Aryelly Rodriguez, Isabella Butcher, Steff C Lewis, A D Bastiaan Vliegenthart, Aravindan Veiraiah, David J Webb, Alasdair Gray
BACKGROUND: Paracetamol poisoning is common worldwide. It is treated with intravenous acetylcysteine, but the standard regimen is complex and associated with frequent adverse effects related to concentration, which can cause treatment interruption. We aimed to ascertain whether adverse effects could be reduced with either a shorter modified acetylcysteine schedule, antiemetic pretreatment, or both. METHODS: We undertook a double-blind, randomised factorial study at three UK hospitals, between Sept 6, 2010, and Dec 31, 2012...
February 22, 2014: Lancet