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https://www.readbyqxmd.com/read/28088016/release-and-cytotoxicity-studies-of-magnetite-ag-antibiotic-nanoparticles-an-interdependent-relationship
#1
Olena Ivashchenko, Anna Woźniak, Emerson Coy, Barbara Peplinska, Jacek Gapinski, Stefan Jurga
Though the cytotoxic properties of magnetite nanoparticles (NPs) are rather well investigated and known to be dose dependent and rather low, surface functionalization can drastically change their properties. To determine whether the cytotoxicity of magnetite/Ag/antibiotic NPs may be associated, among other things, with iron, silver and antibiotic release, this study investigates the release profiles and cytotoxicity of magnetite/Ag/rifampicin and magnetite/Ag/doxycycline NPs compares it similar profiles from magnetite, magnetite/Ag NPs and antibiotics...
January 9, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28079516/adequate-exposure-to-tacrolimus-with-sublingual-administration-in-pediatric-liver-transplant-patients
#2
Natalia Riva, María E Galván, Paulo Cáceres-Guido, Marcelo Dip, Nieves Licciardone, Oscar Imventarza, Paula Schaiquevich, Daniel Buamscha
No abstract text is available yet for this article.
January 12, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28077329/body-schema-plasticity-after-stroke-subjective-and-neurophysiological-correlates-of-the-rubber-hand-illusion
#3
Roberto Llorens, Adrián Borrego, Priscila Palomo, Ausiàs Cebolla, Enrique Noé, Sergi Bermúdez I Badia, Rosa Baños
Stroke can lead to motor impairments that can affect the body structure and restraint mobility. We hypothesize that brain lesions and their motor sequelae can distort the body schema, a sensorimotor map of body parts and elements in the peripersonal space through which human beings embody the reachable space and ready the body for forthcoming movements. Two main constructs have been identified in the embodiment mechanism: body-ownership, the sense that the body that one inhabits is his/her own, and agency, the sense that one can move and control his/her body...
January 8, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28073897/identification-of-alk-ros1-and-ret-fusions-by-a-multiplexed-mrna-based-assay-in-formalin-fixed-paraffin-embedded-samples-from-advanced-non-small-cell-lung-cancer-patients
#4
Noemí Reguart, Cristina Teixidó, Ana Giménez-Capitán, Laia Paré, Patricia Galván, Santiago Viteri, Sonia Rodríguez, Vicente Peg, Erika Aldeguer, Nuria Viñolas, Jordi Remon, Niki Karachaliou, Esther Conde, Fernando Lopez-Rios, Ernest Nadal, Sabine Merkelbach-Bruse, Reinhard Büttner, Rafael Rosell, Miguel A Molina-Vila, Aleix Prat
BACKGROUND: Anaplastic lymphoma receptor tyrosine kinase (ALK), ROS protooncogene 1, receptor tyrosine kinase (ROS1), and ret protooncogene (RET) fusions are present in 5%-7% of patients with advanced non-small-cell lung cancer (NSCLC); their accurate identification is critical to guide targeted therapies. FISH and immunohistochemistry (IHC) are considered the gold standards to determine gene fusions, they have limitations. The nCounter platform is a potentially useful genomic tool for multiplexed detection of gene fusions, but has not been validated in the clinical setting...
January 10, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28073337/microaggressions
#5
Scott O Lilienfeld
The microaggression concept has recently galvanized public discussion and spread to numerous college campuses and businesses. I argue that the microaggression research program (MRP) rests on five core premises, namely, that microaggressions (1) are operationalized with sufficient clarity and consensus to afford rigorous scientific investigation; (2) are interpreted negatively by most or all minority group members; (3) reflect implicitly prejudicial and implicitly aggressive motives; (4) can be validly assessed using only respondents' subjective reports; and (5) exert an adverse impact on recipients' mental health...
January 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/28072559/control-of-endophytic-frankia-sporulation-by-alnus-nodule-metabolites
#6
Anne-Emmanuelle Hay De-Bettignies, Hasna Boubakri, Antoine Buonomo, Marjolaine Rey, Guillaume Meiffren, Laetitia Cotin-Galvan, Gilles Comte, Aude Herrera-Belaroussi
A unique case of microbial symbiont capable of dormancy within its living host cells has been reported in actinorhizal symbioses: some Frankia strains, named Sp+, are able to sporulate inside plant cells, contrarily to Sp- strains. The presence of metabolically slowed down bacterial structures in host cells alters our understanding of symbiosis based on reciprocal benefits between both partners, and its impact on the symbiotic processes remains unknown. The present work reports a metabolomic study of Sp+ and Sp- nodules (from Alnus glutinosa), in order to highlight variabilities associated with in-planta sporulation...
January 10, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/28072537/a-qm-mm-study-of-substituent-and-solvent-effects-on-the-excited-state-dynamics-of-the-photoactive-yellow-protein-chromophore
#7
Francisco Fernández García-Prieto, Aurora Muñoz-Losa, Ignacio Fdez Galván, M Luz Sánchez, Manuel Ángel Aguilar, M Elena Martín
Substituent and solvent effects on the excited state dynamics of the Photoactive Yellow Protein chromophore are studied using the average solvent electrostatic potential from molecular dynamics (ASEP/MD) method. Four molecular models were considered: the ester and thioester derivatives of the p-coumaric acid anion and their methyla ted derivatives. We found that the solvent produces dramatic modifications on the free energy profile of the S1 state: 1) Two twisted structures that are minima in gas phase could not be located in aqueous solution...
January 10, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28071899/near-ir-absorbing-gold-nanoframes-with-enhanced-physiological-stability-and-improved-biocompatibility-for-in-vivo-biomedical-applications
#8
Liying Wang, Yunching Chen, Hsin Yao Lin, Yung-Te Hou, Ling-Chu Yang, Aileen Y Sun, Jia-Yu Liu, Chien-Wen Chang, Dehui Wan
This paper describes the synthesis of near-infrared (NIR)-absorbing gold nanoframes (GNFs) and a systematic study comparing their physiological stability and biocompatibility with those of hollow Au-Ag nanoshells (GNSs), which have been used widely as photothermal agents in biomedical applications because of their localized surface plasmon resonance (LSPR) in the NIR region. The GNFs were synthesized in three steps: galvanic replacement, Au deposition, and Ag dealloying, using silver nanospheres (SNP) as the starting material...
January 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28070020/galvanic-displacement-assembly-of-ultrathin-co3o4-nanosheet-arrays-on-nickel-foam-for-high-performance-supercapacitor
#9
Yuxiu You, Maojun Zheng, Liguo Ma, Xiaoliang Yuan, Bin Zhang, Qiang Li, Faze Wang, Jingnan Song, Dongkai Jiang, Pengjie Liu, Li Ma, Wenzhong Shen
Supercapacitors with high performance are highly desired for many portable electronic devices, electric vehicles and high power electronic devices. Herein, a facile and binder-free synthesis method, galvanic displacement of the precursor followed by heat treatment, is used to fabricate ultrathin Co3O4 nanosheet arrays on nickel foam substrate. The prepared Co3O4 on nickel foam used as a supercapacitor electrode exhibits maximum specific capacitance of 1095 F g-1 at the current density of 1 A g-1 and good cycling stability of 71% retention after 2000 cycling tests...
January 10, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28065651/nitrate-reductase-regulates-plant-nitric-oxide-homeostasis
#10
REVIEW
Alejandro Chamizo-Ampudia, Emanuel Sanz-Luque, Angel Llamas, Aurora Galvan, Emilio Fernandez
Nitrate reductase (NR) is a key enzyme for nitrogen acquisition by plants, algae, yeasts, and fungi. Nitrate, its main substrate, is required for signaling and is widely distributed in diverse tissues in plants. In addition, NR has been proposed as an important enzymatic source of nitric oxide (NO). Recently, NR has been shown to play a role in NO homeostasis by supplying electrons from NAD(P)H through its diaphorase/dehydrogenase domain both to a truncated hemoglobin THB1, which scavenges NO by its dioxygenase activity, and to the molybdoenzyme NO-forming nitrite reductase (NOFNiR) that is responsible for NO synthesis from nitrite...
January 5, 2017: Trends in Plant Science
https://www.readbyqxmd.com/read/28062918/glycine-decarboxylase-and-hif-1%C3%AE-expression-are-negative-prognostic-factors-in-primary-resected-early-stage-non-small-cell-lung-cancer
#11
Sabina Berezowska, José A Galván, Rupert Langer, Lukas Bubendorf, Spasenija Savic, Mathias Gugger, Ralph A Schmid, Thomas M Marti
Glycine decarboxylase (GLDC) was recently described as a critical enzyme of tumor-initiating cells and, thus, a driver of tumorigenesis in lung non-small cell cancer (NSCC). It is important in metabolism under hypoxic conditions. Hypoxia-inducible factor 1-alpha (HIF-1α) is the unique subunit that determines HIF system activity, thereby regulating the adverse effects of hypoxia on cancer outcome. We examined the expression and prognostic significance of GLDC and HIF-1α in primary resected stage I/II NSCC...
January 7, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28062129/-methodological-guideline-for-the-efficacy-and-safety-assessment-of-new-pharmaceuticals-implementation-of-eunethta-s-recommendations
#12
Ruth Ubago Pérez, María Auxiliadora Castillo Muñoz, Mercedes Galván Banqueri, Raúl García Estepa, Eva Rocío Alfaro Lara, María Dolores Vega Coca, Carmen Beltrán Calvo, Teresa Molina López
The European network for Health Technology Assessment (EUnetHTA) is the network of public health technology assessment (HTA) agencies and entities from across the EU. In this context, the HTA Core Model(®), has been developed. The Andalusian Agency for Health Technology Assessment (AETSA) is a member of the Spanish HTA Network and EUnetHTA collaboration In addition, AETSA participates in the new EUnetHTA Joint Action 3 (JA, 2016-2019). Furthermore, AETSA works on pharmaceutical assessments. Part of this work involves drafting therapeutic positioning reports (TPRs) on drugs that have recently been granted marketing authorisation, which is overseen by the Spanish Agency of Medicines and Medical Devices (AEMPS)...
January 3, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28061966/new-treatments-for-hair-loss
#13
S Vañó-Galván, F Camacho
The treatment of hair loss is an important part of clinical dermatology given the prevalence of the problem and great impact on patients' quality of life. Many new treatments have been introduced in recent years. This review summarizes the main ones in 4 groups: a) For androgenetic alopecia, we discuss new excipients for oral minoxidil, dutasteride, and finasteride as well as new forms of topical application; prostaglandin agonists and antagonists; low-level laser therapy; and regenerative medicine with Wnt signaling activators and stem cell therapy...
January 3, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28060420/multimetallic-hierarchical-aerogels-shape-engineering-of-the-building-blocks-for-efficient-electrocatalysis
#14
Bin Cai, Arezoo Dianat, René Hübner, Wei Liu, Dan Wen, Albrecht Benad, Luisa Sonntag, Thomas Gemming, Gianaurelio Cuniberti, Alexander Eychmüller
A new class of multimetallic hierarchical aerogels composed entirely of interconnected Ni-Pdx Pty nano-building blocks with in situ engineered morphologies and compositions is demonstrated. The underlying mechanism of the galvanic shape-engineering is elucidated in terms of nanowelding of intermediate nanoparticles. The hierarchical aerogels integrate two levels of porous structures, leading to improved electrocatalysis performance.
January 6, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28058807/a-new-triazine-based-covalent-organic-framework-for-high-performance-capacitive-energy-storage
#15
Asim Bhaumik, Piyali Bhanja, Kousik Bhunia, Debabrata Pradhan, Sabuj K Das, Ryuto Kimura, Yuh Hijikata, Stephan Irle
A new covalent organic framework material TDFP-1 has been designed through solvothermal Schiff base condensation reaction using two monomers 1,3,5-tris-(4-aminophenyl)triazine (TAPT) and 2,6-diformyl-4-methylphenol (DFP). Due to the high specific surface area of 651 m2 g-1 and extended π-conjugation with inherent microporosity, TDFP-1 exhibited excellent energy storage capacity with a maximum specific capacitance (SC) of 354 Fg-1, at 2 mV/s scan rate and good cyclic stability with 95% retention of its initial specific capacitance after 1000 cycles at 10 A g-1...
January 6, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28054692/in-situ-liquid-cell-electron-microscopy-of-ag-au-galvanic-replacement-reactions
#16
Eli A Sutter, Peter W Sutter
Galvanic replacement reactions are important as they transform nanoparticle templates into complex porous and hollow metal or alloy nanostructures with interesting properties for a variety of applications. Real-time liquid cell electron microscopy (LCEM) observations of the transformation of solid nanoparticles into hollow shell and cage bimetallic nanostructures are challenging because the high-energy electron beam strongly affects the galvanic process via species such as aqueous electrons and hydroxyl radicals generated through the radiolysis of water in the liquid cell...
January 5, 2017: Nanoscale
https://www.readbyqxmd.com/read/28054683/low-pt-content-ternary-pdcupt-nanodendrites-an-efficient-electrocatalyst-for-oxygen-reduction-reaction
#17
Shaofang Fu, Chengzhou Zhu, Junhua Song, Peina Zhang, Mark H Engelhard, Haibing Xia, Dan Du, Yuehe Lin
Dendritic nanostructures are capturing increasing attention in electrocatalysis owing to their unique structural features and low density. Herein, we report for the first time, bromide ion mediated synthesis of low Pt-content PdCuPt ternary nanodendrites via galvanic replacement reaction between a Pt precursor and a PdCu template in aqueous solution. The experimental results show that the ternary PdCuPt nanodendrites present enhanced electrocatalytic performance for oxygen reduction reaction in acid solution compared with commercial Pt/C as well as some state-of-the-art catalysts...
January 5, 2017: Nanoscale
https://www.readbyqxmd.com/read/28054312/latent-inhibition-reduces-nocebo-nausea-even-without-deception
#18
V F Quinn, E J Livesey, B Colagiuri
BACKGROUND: Nocebo nausea is a debilitating and prevalent side effect that can develop after conditioning occurs between cues present in the treatment context and the experience of nausea. Interventions that retard conditioning may therefore be able to reduce nocebo nausea. PURPOSE: To test whether 'latent inhibition', where pre-exposing cues in the absence of an outcome retards subsequent learning about those cues, could reduce nocebo nausea in healthy adults. METHODS: We examined this possibility using a Galvanic Vestibular Stimulation (GVS) model of nausea in healthy participants, with pre-exposure to the treatment cues achieved using a placebo version of GVS...
January 4, 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/28045497/giant-temperature-coefficient-of-resistivity-and-cryogenic-sensitivity-in-silicon-with-galvanically-displaced-gold-nanoparticles-in-freeze-out-region
#19
Seung-Hoon Lee, Seongpil Hwang, Jae-Won Jang
The temperature coefficient of resistivity (TCR) and cryogenic sensitivity (Sv) of p-type silicon (p-Si) in the low-temperature region (10-30 K) are remarkably improved by increasing the coverage of galvanically displaced Au nanoparticles (NPs). By increasing the galvanic displacement time from 10 s to 30 s, the average surface roughness (Ra) of the samples increases from 0.31 to 2.31 nm, and the coverage rate of Au NPs increases from 3.1% to 21.9%. In the freeze-out region of the sample, an up to 35% increase of TCR and dramatically improved Sv of p-Si (~ 5785%) are observed with Au coverage of 21...
January 3, 2017: ACS Nano
https://www.readbyqxmd.com/read/28044449/efficacy-of-a-randomized-trial-examining-commercial-weight-loss-programs-and-exercise-on-metabolic-syndrome-in-overweight-and-obese-women
#20
Claire Baetge, Conrad P Earnest, Brittanie Lockard, Adriana M Coletta, Elfego Galvan, Christopher Rasmussen, Kyle Levers, Sunday Y Simbo, Y Peter Jung, Majid Koozehchian, Jonathan Oliver, Ryan Dalton, Brittany Sanchez, Michael J Byrd, Deepesh Khanna, Andrew Jagim, Julie Kresta, Mike Greenwood, Richard B Kreider
While commercial dietary weight-loss programs typically advise exercise, few provide actual programing. The goal of this study was to compare the Curves Complete 90-day Challenge (CC, n = 29), which incorporates exercising and diet, to programs advocating exercise (Weight Watchers Points Plus (WW, n = 29), Jenny Craig At Home (JC, n = 27), and Nutrisystem Advance Select (NS, n = 28)) or control (n = 20) on metabolic syndrome (MetS) and weight loss. We randomized 133 sedentary, overweight women (age, 47 ± 11 years; body mass, 86 ± 14 kg; body mass index, 35 ± 6 kg/m(2)) into respective treatment groups for 12 weeks...
January 3, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
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