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https://www.readbyqxmd.com/read/28427546/is-the-bronchodilator-test-an-useful-tool-to-measure-asthma-control
#1
Marta Ferrer Galván, Francisco Javier Alvarez Gutiérrez, Auxiliadora Romero Falcón, Beatriz Romero Romero, Antonia Sáez, Juan Francisco Medina Gallardo
INTRODUCTION: Asthma control includes the control of symptoms and future risk. We sought to evaluate the usefulness of the degree of spirometric reversibility of the forced expiratory volume in one second (FEV1) as the target parameter of control. METHODOLOGY: Patients with bronchial asthma were followed up for one year. The clinical, functional, inflammatory and control parameters of the asthma were collected. The area under the curve (AUC) was estimated to establish the cutoff point of the post-bronchodilator FEV1 reversibility in relation to non-control asthma...
May 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28426907/frontal-fibrosing-alopecia-clinical-and-prognostic-classification
#2
O M Moreno-Arrones, D Saceda-Corralo, P Fonda-Pascual, A R Rodrigues-Barata, D Buendía-Castaño, A Alegre-Sánchez, C Pindado-Ortega, M Molins, D Perosanz, G Segurado-Miravalles, P Jaén, S Vañó-Galván
BACKGROUND: Frontal fibrosing alopecia (FFA) is a chronic scarring alopecia with an unpredictable evolution. There are no current classifications of this disease that may predict its prognosis. OBJECTIVE: To analyze the differences in clinical presentation and evolution of FFA patients and to create a clinical and prognostic classification METHODS: We conducted a retrospective analytical study of FFA patients. Clinical characteristics of frontal hairline recession were used as the sorting variable between patterns of presentation...
April 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28426227/monovalent-vs-divalent-cation-diffusion-in-thiospinel-ti2s4
#3
Patrick Bonnick, Xiaoqi Sun, Ka-Cheong Lau, Chen Liao, Linda F Nazar
Measurement of Li+ and Mg2+ diffusion in the same Ti2S4 thiospinel material in three electrode cells at elevated temperature negates factors of surface area and cell design, allowing the direct comparison of their diffusion coefficients (D). D values were measured using the Galvanic Intermittent Titration Technique (GITT) as a function of both ion concentration (x) and temperature. During discharge at 55 °C, DLi descends gradually from 2×10-8 cm2/s by an order of magnitude over the range 0 < xLi < 1...
April 20, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28424655/sustained-and-transient-vestibular-systems-a-physiological-basis-for-interpreting-vestibular-function
#4
REVIEW
Ian S Curthoys, Hamish G MacDougall, Pierre-Paul Vidal, Catherine de Waele
Otolithic afferents with regular resting discharge respond to gravity or low-frequency linear accelerations, and we term these the static or sustained otolithic system. However, in the otolithic sense organs, there is anatomical differentiation across the maculae and corresponding physiological differentiation. A specialized band of receptors called the striola consists of mainly type I receptors whose hair bundles are weakly tethered to the overlying otolithic membrane. The afferent neurons, which form calyx synapses on type I striolar receptors, have irregular resting discharge and have low thresholds to high frequency (e...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28423537/limitations-in-predicting-pam50-intrinsic-subtype-and-risk-of-relapse-score-with-ki67-in-estrogen-receptor-positive-her2-negative-breast-cancer
#5
Aranzazu Fernandez-Martinez, Tomás Pascual, Giuseppe Perrone, Serafin Morales, Juan de la Haba, Milagros González-Rivera, Patricia Galván, Francesca Zalfa, Michela Amato, Lucia Gonzalez, Miquel Prats, Federico Rojo, Luis Manso, Laia Paré, Immaculada Alonso, Joan Albanell, Ana Vivancos, Antonio González, Judit Matito, Sonia González, Pedro Fernandez, Barbara Adamo, Montserrat Muñoz, Margarita Viladot, Carme Font, Francisco Aya, Maria Vidal, Rosalía Caballero, Eva Carrasco, Vittorio Altomare, Giuseppe Tonini, Aleix Prat, Miguel Martin
PAM50/Prosigna gene expression-based assay identifies three categorical risk of relapse groups (ROR-low, ROR-intermediate and ROR-high) in post-menopausal patients with estrogen receptor estrogen receptor-positive (ER+)/ HER2-negative (HER2-) early breast cancer. Low risk patients might not need adjuvant chemotherapy since their risk of distant relapse at 10-years is below 10% with endocrine therapy only. In this study, 517 consecutive patients with ER+/HER2- and node-negative disease were evaluated for Ki67 and Prosigna...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28420340/genetics-and-mapping-of-a-new-anthracnose-resistance-locus-in-andean-common-bean-paloma
#6
Sandra Aparecida de Lima Castro, Maria Celeste Gonçalves-Vidigal, Thiago Alexandre Santana Gilio, Giselly Figueiredo Lacanallo, Giseli Valentini, Vanusa da Silva Ramos Martins, Qijian Song, Marta Zulema Galván, Oscar P Hurtado-Gonzales, Marcial Antonio Pastor-Corrales
BACKGROUND: The Andean cultivar Paloma is resistant to Mesoamerican and Andean races of Colletotrichum lindemuthianum, the fungal pathogen that causes the destructive anthracnose disease in common bean. Remarkably, Paloma is resistant to Mesoamerican races 2047 and 3481, which are among the most virulent races of the anthracnose pathogen. Most genes conferring anthracnose resistance in common bean are overcome by these races. The genetic mapping and the relationship between the resistant Co-Pa gene of Paloma and previously characterized anthracnose resistance genes can be a great contribution for breeding programs...
April 18, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28420119/the-modeling-and-simulation-of-the-galvanic-coupling-intra-body-communication-via-handshake-channel
#7
Maoyuan Li, Yong Song, Wansong Li, Guangfa Wang, Tianpeng Bu, Yufei Zhao, Qun Hao
Intra-body communication (IBC) is a technology using the conductive properties of the body to transmit signal, and information interaction by handshake is regarded as one of the important applications of IBC. In this paper, a method for modeling the galvanic coupling intra-body communication via handshake channel is proposed, while the corresponding parameters are discussed. Meanwhile, the mathematical model of this kind of IBC is developed. Finally, the validity of the developed model has been verified by measurements...
April 14, 2017: Sensors
https://www.readbyqxmd.com/read/28420097/synthesis-of-curcuminoids-and-evaluation-of-their-cytotoxic-and-antioxidant-properties
#8
María Concepción Lozada-García, Raúl G Enríquez, Teresa O Ramírez-Apán, Antonio Nieto-Camacho, Juan Francisco Palacios-Espinosa, Zeltzin Custodio-Galván, Olivia Soria-Arteche, Jaime Pérez-Villanueva
Curcumin (1) and ten derivatives (2-11) were synthesized and evaluated as cytotoxic and antioxidant agents. The results of primary screening by Sulforhodamine B assay against five human cancer cell lines (U-251 MG, glioblastoma; PC-3, human prostatic; HCT-15, human colorectal; K562, human chronic myelogenous leukemia; and SKLU-1, non-small cell lung cancer) allowed us to calculate the half maximal inhibitory concentration (IC50) values for the more active compounds against HCT-15 and K562 cell lines. Compounds 2 and 10 were the most active against both cell lines and were more active than curcumin itself...
April 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28418061/self-powered-electrochemical-systems-as-neurochemical-sensors-toward-self-triggered-in-vivo-analysis-of-brain-chemistry
#9
Fei Wu, Ping Yu, Lanqun Mao
Real-time in vivo analysis of neurochemical dynamics has great physiological and pathological implications for a full understanding of the brain. Self-powered electrochemical systems (SPESs) built on galvanic cell configurations bear the advantages of easy miniaturization for implantation and no interference to electric activities of neurons over traditional externally-powered electrochemical sensors for self-triggered in vivo analysis. However, this is still a new concept for in vivo neurochemical sensing with few implanted examples reported so far...
April 18, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28414741/effects-of-music-on-arousal-during-imagery-in-elite-shooters-a-pilot-study
#10
Garry Kuan, Tony Morris, Peter Terry
Beneficial effects of music on several performance-related aspects of sport have been reported, but the processes involved are not well understood. The purpose of the present study was to investigate effects of relaxing and arousing classical music on physiological indicators and subjective perceptions of arousal during imagery of a sport task. First, appropriate music excerpts were selected. Then, 12 skilled shooters performed shooting imagery while listening to the three preselected music excerpts in randomized order...
2017: PloS One
https://www.readbyqxmd.com/read/28413431/asian-house-rats-may-facilitate-their-invasive-success-through-suppressing-brown-rats-in-chronic-interaction
#11
Hong-Ling Guo, Hua-Jing Teng, Jin-Hua Zhang, Jian-Xu Zhang, Yao-Hua Zhang
BACKGROUND: The Asian house rat (Rattus tanezumi) and the brown rat (Rattus norvegicus) are closely related species and are partially sympatric in southern China. Over the past 20 years, R. tanezumi has significantly expanded northward in China and partially replaced the native brown rat subspecies, R. n. humiliatus. Although invasive species are often more aggressive than native species, we did not observe interspecific physical aggression between R. tanezumi and R. n. humiliatus. Here, we focused on whether or not R...
2017: Frontiers in Zoology
https://www.readbyqxmd.com/read/28406061/effect-of-packing-material-on-organic-matter-removal-efficiency-in-an-anaerobic-aerobic-baffled-bioreactor
#12
Jacobo Tabla-Hernandez, E Lopez-Galvan
The aim of the present work was to study the effect of packing material on the organic matter removal efficiency (OMRE) in an anaerobic-aerobic baffled bioreactor (AAB). For this purpose, two different experiments were conducted with two types of packing material: activated carbon particles (AC) and polyurethane foam (PF). The system consisted of two treatments; the first one was anaerobic, where it took place hydrolysis, acetogenesis and methanogenesis. In anaerobic chambers, there were no packing material and the operating conditions were the same in both experiments...
April 13, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28403336/attitude-and-knowledge-about-foot-health-a-spanish-view
#13
Daniel López-López, Ricardo García-Mira, Patricia Palomo-López, Rubén Sánchez-Gómez, José Ramos-Galván, Natalia Tovaruela-Carrión, Matilde García-Sánchez
Objective: to explore attitudes towards patients' self-reported data about foot health-related beliefs from a behavioural and attitudinal perspective. Methods: a sample of 282 participants of a mean age of 39.46 ± 16.026 came to a health centre where self-reported demographic, clinical characteristics and beliefs relating to foot health data were registered, informants' completed all the stages of the research process. Results: the results of the analysis revealed an 8-factor factorial structure based on (1) podiatric behaviours, (2) the intention to carry out protective behaviour, (3) attitudinal beliefs, (4) normative beliefs, (5) needs, (6) apathy, (7) self-care, and (8) the general perception of foot health...
April 6, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28402053/pseudoreplication-and-the-usage-of-biomarkers-in-ecotoxicological-bioassays
#14
Flávio H Tincani, Grabrieli L Galvan, Antonio E M L Marques, Gustavo S Santos, Letícia S Pereira, Thiago A da Silva, Helena C Silva de Assis, Ronilson V Barbosa, Marta M Cestari
Pseudoreplication is a widely discussed topic in the scientific community. Its principal critique concerns the lack of independence in flawed experimental designs and the use of inferential statistics to test the hypothesis of such experiments. Thirty years after its appearance, it remains misunderstood by many researchers, including ecotoxicologists. In this work, we will try to clarify some of its concepts by filling in what seems to be a gap in the terminology of manipulative experiments. We propose the term experimental medium to refer strictly to the relevant spatial scale of the experiment, in order to preserve the specificity of the experimental and observational units, and to display pseudoreplication as a kind of misinterpretation and/or misanalysis of inferential statistics...
April 12, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28397912/a-new-heterostructured-sers-substrate-free-standing-silicon-nanowires-decorated-with-graphene-encapsulated-gold-nanoparticles
#15
Yuan Li, John Dykes, Todd Gilliam, Nitin Chopra
Heterostructures of one-dimensional nanowire supported graphene/plasmonic nanoparticles are promising for future SERS-based chemical sensors. In this paper, we report a novel heterostructured SERS substrate composed of free-standing Si nanowires and surface-decorating Au/graphene nanoparticles. We successfully developed a unique CVD approach for the cost-effective and large-scale growth of free-standing Si nanowires. Au nanoparticles were decorated on the Si nanowires using a galvanic deposition - an annealing approach...
April 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28392388/design-characterization-and-evaluation-of-hydroxyethylcellulose-based-novel-regenerable-supersorbent-for-heavy-metal-ions-uptake-and-competitive-adsorption
#16
Azhar Abbas, Muhammad Ajaz Hussain, Muhammad Sher, Muhammad Imran Irfan, Muhammad Nawaz Tahir, Wolfgang Tremel, Syed Zajif Hussain, Irshad Hussain
Hydroxyethylcellulose succinate-Na (HEC-Suc-Na) was designed and evaluated for removal of some heavy metal ions from aqueous solution. Pristine sorbent HEC-Suc-Na was thoroughly characterized by FTIR and solid-state CP/MAS (13)C NMR spectroscopy, SEM-EDS and zero point charge analyses. Langmuir isotherm, pseudo second order kinetic and ion exchange models provided best fit to the experimental data of sorption of metal ions. Maximum sorption capacities of supersorbent HEC-Suc-Na for sorption of heavy metal ions from aqueous solution as calculated by Langmuir isotherm model were found to be 1000, 909...
April 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28391373/noisy-galvanic-vestibular-stimulation-an-emerging-treatment-option-for-bilateral-vestibulopathy
#17
Max Wuehr, Julian Decker, Roman Schniepp
Patients with bilateral vestibulopathy (BVP) suffer from persistent imbalance during standing and walking as well as an impaired gaze stabilization during head movements. Disabilities associated with BVP severely compromise patients' daily activities and are often linked to an increased risk of falls. Currently, the only established treatment option in BVP is physical therapy. However, treatment effects of physical therapy in BVP are most often limited and many patients do not adequately recover performance...
April 8, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28389515/androgen-signaling-in-prostate-cancer
#18
Charles Dai, Hannelore Heemers, Nima Sharifi
The androgen-signaling axis plays a pivotal role in the pathogenesis of prostate cancer. Since the landmark discovery by Huggins and Hodges, gonadal depletion of androgens has remained a mainstay of therapy for advanced disease. However, progression to castration-resistant prostate cancer (CRPC) typically follows and is largely the result of restored androgen signaling. Efforts to understand the mechanisms behind CRPC have revealed new insights into dysregulated androgen signaling and intratumoral androgen synthesis, which has ultimately led to the development of several novel androgen receptor (AR)-directed therapies for CRPC...
April 7, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28388997/barriers-to-health-care-providers-provision-of-long-acting-reversible-contraception-to-adolescent-and-nulliparous-young-women
#19
Brooke Hopkins
Despite recommendations for long-acting reversible contraception (LARC) as a first-line contraceptive method for adolescents and young women, its use in the United States remains low. This integrative review highlights previously unidentified barriers to health care providers' provision of LARC to adolescent and nulliparous young women. Four themes emerged: Appropriateness of Candidates and Contraceptive Safety, Provider Training and Work Setting, Appropriate Resources, and Opportunity. Raising awareness of barriers to LARC use may galvanize providers to find solutions...
April 2017: Nursing for Women's Health
https://www.readbyqxmd.com/read/28388686/vestibular-stimulation-induced-facilitation-of-cervical-premotoneuronal-systems-in-humans
#20
Shinya Suzuki, Tsuyoshi Nakajima, Shun Irie, Ryohei Ariyasu, Tomoyoshi Komiyama, Yukari Ohki
It is unclear how descending inputs from the vestibular system affect the excitability of cervical interneurons in humans. To elucidate this, we investigated the effects of galvanic vestibular stimulation (GVS) on the spatial facilitation of motor-evoked potentials (MEPs) induced by combined pyramidal tract and peripheral nerve stimulation. To assess the spatial facilitation, electromyograms were recorded from the biceps brachii muscles (BB) of healthy subjects. Transcranial magnetic stimulation (TMS) over the contralateral primary motor cortex and electrical stimulation of the ipsilateral ulnar nerve at the wrist were delivered either separately or together, with interstimulus intervals of 10 ms (TMS behind)...
2017: PloS One
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